LOCUS       NZ_JAHFZY010000005     22559 bp    DNA     linear   CON 14-SEP-2024
DEFINITION  Actinomadura sp. NEAU-AAG7 Scaffold5, whole genome shotgun sequence.
ACCESSION   NZ_JAHFZY010000005
VERSION     NZ_JAHFZY010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Actinomadura sp. NEAU-AAG7
  ORGANISM  Actinomadura sp. NEAU-AAG7
            Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
            Thermomonosporaceae; Actinomadura.
REFERENCE   1  (bases 1 to 803282)
  AUTHORS   Xu,X. and Zhao,J.
  TITLE     Actinomadura oryzae sp. nov., a novel actinobacterium with the
            activity of releasig potassium isolated from rhizosphere soil of
            rice in Sanya
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 803282)
  AUTHORS   Xu,X. and Zhao,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2021) College of Life Sciences, Northeast
            Agricultural University, 600 Changjiang Road, Xiangfang District,
            Harbin 150030, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04 OR JUL-2018
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 400x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018603865.1-RS_2024_09_14
            Annotation Date                   :: 09/14/2024 03:10:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,952
            CDSs (total)                      :: 7,871
            Genes (coding)                    :: 7,813
            CDSs (with protein)               :: 7,813
            Genes (RNA)                       :: 81
            rRNAs                             :: 5, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 69
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 58
            CDSs (without protein)            :: 58
            Pseudo Genes (ambiguous residues) :: 0 of 58
            Pseudo Genes (frameshifted)       :: 6 of 58
            Pseudo Genes (incomplete)         :: 53 of 58
            Pseudo Genes (internal stop)      :: 1 of 58
            Pseudo Genes (multiple problems)  :: 2 of 58
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 16:01:00
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 644429
            Orig. end                         :: 666988
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAHFZY010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..22559
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-iii"
                     /region_number="4"
                     /rules="(micKC and not PKS_KS)"
                     /tool="antismash"
     cand_cluster    1..22559
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(micKC and not PKS_KS)"
                     /kind="single"
                     /product="lanthipeptide-class-iii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22559
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12559](-)"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12559)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(micKC and not PKS_KS)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iii"
                     /protocluster_number="1"
     misc_feature    complement(584..603)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            complement(760..1002)
                     /locus_tag="KLI87_RS25670"
                     /old_locus_tag="KLI87_25670"
     CDS             complement(760..1002)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657903.1"
                     /locus_tag="KLI87_RS25670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25670"
                     /product="hypothetical protein"
                     /protein_id="WP_156215432.1"
                     /transl_table=11
                     /translation="MDEREGRRGDVQELSEFELAVYETVAEIDKGGGAADFDTVSRLVA
                     APEEELWAALGHLVEVNHLHSTPKGYVLGPHDWAP"
     gene            complement(1031..2056)
                     /gene="sbnB"
                     /locus_tag="KLI87_RS25675"
                     /old_locus_tag="KLI87_25675"
     CDS             complement(1031..2056)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019290 - siderophore biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sbnB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657902.1"
                     /locus_tag="KLI87_RS25675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25675"
                     /product="2,3-diaminopropionate biosynthesis protein SbnB"
                     /protein_id="WP_214618997.1"
                     /transl_table=11
                     /translation="MTQAPTFAVISGAQVHEVIGGHEERVTRTVEAAYRLHGEGQTVNP
                     DSYFLRFPDRPSDRIIALPASVKGEIGVHGIKWISSFPGNVAAGIPRASAVLILNDAET
                     GYPFACLESSIISAARTAASAALAAVTLADLRGERPRRVGFVGTGLIARYIHTYLAGNG
                     FAFDELGVHDLSAEHAEGFKGYLEGAGPGTVTIHGSAHDLVRASDLVVFATVAGEPHVT
                     DPAWFAHNPLVLHVSLRDLSPEIILSAWNVVDDVEHCLKAGTSPHLAEQKTGGRDFVAG
                     TLYDVLTGAIEPPADRPIVFSPFGLGVLDLAVARYVYDEVAASGALSTVPGFFHEMRRY
                     G"
     misc_feature    complement(2080..2100)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.69"
                     /tool="antismash"
     gene            2238..2969
                     /locus_tag="KLI87_RS25680"
                     /old_locus_tag="KLI87_25680"
     CDS             2238..2969
                     /NRPS_PKS="Domain: Thioesterase (15-239). E-value: 6.5e-59.
                     Score: 192.1. Matches aSDomain:
                     nrpspksdomains_KLI87_RS25680_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634304.1"
                     /locus_tag="KLI87_RS25680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25680"
                     /product="thioesterase II family protein"
                     /protein_id="WP_214618998.1"
                     /sec_met_domain="Thioesterase (E-value: 4.6e-55, bitscore:
                     182.7, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 3.8e-10, bitscore:
                     36.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTWFRCAETRPWASTRLFCLPHAGGSAVSYRSWTKEADPSVEVRA
                     VQYPGRADRLADPLVGDAHELARLVAGAMAPLLDRPAALFGHSMGAVVAYEVARLLQER
                     GSAPVHLFASGARPPHDRGDDRVSDRDDEGVLAEMTRLGGTDAEILADPELRELVLPYV
                     RNDFALVENYAHLPGTRLEVPVTVIVGDDDPHVTPAQARRWAELTDGPFAMTVMEGGHF
                     YLTPHQSAVIAEIHRALGVAG"
     aSDomain        2283..2954
                     /ASF="active site serine inconclusive"
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_KLI87_RS25680_Thioesterase.1"
                     /evalue="6.50E-59"
                     /label="KLI87_RS25680_Thioesterase.1"
                     /locus_tag="KLI87_RS25680"
                     /protein_end="239"
                     /protein_start="15"
                     /score="192.1"
                     /tool="antismash"
                     /translation="RLFCLPHAGGSAVSYRSWTKEADPSVEVRAVQYPGRADRLADPLV
                     GDAHELARLVAGAMAPLLDRPAALFGHSMGAVVAYEVARLLQERGSAPVHLFASGARPP
                     HDRGDDRVSDRDDEGVLAEMTRLGGTDAEILADPELRELVLPYVRNDFALVENYAHLPG
                     TRLEVPVTVIVGDDDPHVTPAQARRWAELTDGPFAMTVMEGGHFYLTPHQSAVIAEIHR
                     AL"
     CDS_motif       2475..2540
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_KLI87_RS25680_0001"
                     /evalue="3.40E-09"
                     /label="NRPS-te1"
                     /locus_tag="KLI87_RS25680"
                     /protein_end="101"
                     /protein_start="79"
                     /score="29.1"
                     /tool="antismash"
                     /translation="RPAALFGHSMGAVVAYEVARLL"
     gene            complement(3093..4187)
                     /locus_tag="KLI87_RS25685"
                     /old_locus_tag="KLI87_25685"
     CDS             complement(3093..4187)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657892.1"
                     /locus_tag="KLI87_RS25685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25685"
                     /product="S1 family peptidase"
                     /protein_id="WP_308166168.1"
                     /transl_table=11
                     /translation="MKIRHARISGAAVTMTATGVMASALVAAPTANAAPQAPAAPAGAV
                     TTAQAAQARTAATLARRLGSRSAGSYIDAATRQLVVTVTDASAARAVRAAGAQPKTVAR
                     SGADLKRVMAALKRDATVPGTAWAADPASNKVVLSMDSSVTGAGLAKVRRAVAKQGAAV
                     RTERVAGTFRTFTRGGEAIWTSGGRCSLGFNVKKGGAYYFLTAGHCTNIGTSWYSDQGK
                     TRLLGNTENGSFPGNDYGIVKYSSTPEDTQGSVSLYNGGSQDITSAGTPTVGQTVQRSG
                     STTQVHSGQVTGLNQTVNYREGSVTGLIKTTVCAEPGDSGGSLFAGATALGLTSGGSGN
                     CSSGGTTFFQPVTEPLQVYGAQVY"
     misc_feature    4276..4289
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.74"
                     /tool="antismash"
     gene            4428..5405
                     /locus_tag="KLI87_RS25690"
                     /old_locus_tag="KLI87_25690"
     CDS             4428..5405
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017539302.1"
                     /locus_tag="KLI87_RS25690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25690"
                     /product="ornithine cyclodeaminase family protein"
                     /protein_id="WP_214618999.1"
                     /transl_table=11
                     /translation="MTLLLTRSDLESVLDPAACLAELRRGFTAGSAGGDAARRVVARPP
                     GPGTATALLPGAVEGIPAYTVKVNAKFPGSRPALRGVVCLHDLGTGELLALLDSATVTA
                     WRTGLAAALGTHVLARPGADAVAVVGAGAQAELVMRGLAALRPVRRLAVHDLDAGRAEA
                     FAARHGALLGLDASAAASYGAGPDAVREAVRDAGIVVTATWARSPILDAPDVAPGAHVT
                     SLGADEPGKAELAPGLLRAARVVVDDVALAAEMGALAGAGPEVERSAATLGDVLAGRAP
                     GRAAEDGRTVYAPVGLPWQDLALSWAAFNMARSNQVGLAFDFLG"
     misc_feature    complement(5425..5443)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.24"
                     /tool="antismash"
     misc_feature    5428..5441
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 13.61"
                     /tool="antismash"
     misc_feature    5428..5442
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.64"
                     /tool="antismash"
     misc_feature    5429..5442
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.52"
                     /tool="antismash"
     misc_feature    complement(5430..5443)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.12"
                     /tool="antismash"
     misc_feature    5451..5464
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.58"
                     /tool="antismash"
     misc_feature    complement(5451..5466)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 17.0"
                     /tool="antismash"
     misc_feature    complement(5456..5469)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 13.85"
                     /tool="antismash"
     misc_feature    5456..5473
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.98"
                     /tool="antismash"
     misc_feature    5459..5475
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 14.77"
                     /tool="antismash"
     misc_feature    5477..5497
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.34"
                     /tool="antismash"
     misc_feature    complement(5684..5699)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.86"
                     /tool="antismash"
     gene            5688..>6212
                     /locus_tag="KLI87_RS25695"
                     /old_locus_tag="KLI87_25695"
                     /pseudo=""
     CDS             5688..>6212
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF012301.5"
                     /locus_tag="KLI87_RS25695"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25695"
                     /product="DNA-binding response regulator"
                     /pseudo=""
                     /transl_table=11
                     /translation="MIRILLAEEAPLLRGGLVAFFGGVKDLDVVAAIDSGDHLLRMANL
                     RRPDVALIDVALPGLDGFSASRRLREELPDCRTVLMSGRHRTGDLRRAVTARAAGLVLK
                     DTSPGALVDAIRRVADGQRVVDAEVAFSELGSAVSPLTERESEVLELASRGASAAQIAE
                     DLVLTIGTVRNH"
     misc_feature    5820..5822
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(6144..8084)
                     /locus_tag="KLI87_RS25700"
                     /old_locus_tag="KLI87_25700"
     CDS             complement(6144..8084)
                     /EC_number="7.-.-.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853931.1"
                     /locus_tag="KLI87_RS25700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25700"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_250904203.1"
                     /transl_table=11
                     /translation="MTSRREAARLLWRTAAGAVRGRPRAASAVLAWSLLEAVPTAVFGR
                     AVAQATDAFIDDRPVRAAAWLAALAVAAVVGAYGSRRLYLALAALVEPFRDDLVRAVTR
                     GALYRSLRGRPDTGAVARLTHQVEIVRDTFGGILVVARGFVFAAGAALLGLATLMPEVT
                     LLVLPPLVAGLVLFGAAFGAAAIRQRALVVGEEEIAERTTALAEGLRDVVACGAEDQVR
                     ERLAAAVDAQAAAGRAVARFAAVRALALAVSGWLPLLVVLAAAPWLMRRGATPGMVVGA
                     LAYVLHGLQPALRTLVQGMGGSGLRLAVTLGRILETSAPVAPPLPPVAEAPREERADAP
                     AVELRGVTFAYGASARPVISGLDLTIPRGDHLAVVGPSGIGKSTLAALVAGLLAPLEGE
                     VLVAGRPAGDPAARVLIPQEAYVFTGTVHENLTYLAPDARDEDVVRAADELGLARLVRD
                     LGGYGATVDPAALTEGQRQLIALCRAYLAPAPLIVLDEAACRLDAAAEARAEEAFARRP
                     GTLVVIAHRVSSAVRARRVLVLDGTHARVGRHADLPAVSPLYRDLIGRWESGDPDRPSP
                     EAPGTAGPEGPGTADPEGPGGSQPPGLLGDPDRVHPVPRADLPVDAGEVVADRPDRQDE
                     VLGDLRRRGPA"
     gene            complement(8101..9801)
                     /locus_tag="KLI87_RS25705"
                     /old_locus_tag="KLI87_25705"
     CDS             complement(8101..9801)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017621963.1"
                     /locus_tag="KLI87_RS25705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25705"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_156215437.1"
                     /transl_table=11
                     /translation="MTSPTTAGADRLLVGAARHSGGWTGLVAATAVADALAAVLLPLAL
                     ARAVDAAPPGGPSAASALWPCVALVLLSATAEVLSELATGCSAARATAWLRHALVRHVL
                     AVGPALRVPPGDVAGRTVGGAAEAGTAPSAAPEAAVALLPPLGALTVLAFIDWRLAVAV
                     AVALPAIVLLLRVFVRDITASAHRYLSVQGTIAGRLAEALAGARTIAAAGTAEREAERV
                     LRPLPGLRAEGETMWTVQGGVAARGLLTLLLLQVAAVGAAGAELMAGRVTAGELVATVQ
                     YAGLAAGFGPVLTHVLRLGRARAGARRAAEILEQPAPADGDAAVPEGRGTLEFRGVSAG
                     GVLHGLDLTVPGGLAVAVVGRSGAGKSLLAALAGRLADPDRGEVLLDGAPLPRLARTEL
                     RRHVGYAFARPTLFGETVLDAIAFGPCRPPESWLRESARTACADDFVRRLPQGYATPLA
                     DAPMSGGELQRMGLARAFAHAGRVLVLDDATSSLDTVTEVQVTGAVLDRFGDRTRLIIA
                     HRAGTAARADLVVWLDGGRVRGRGTHAELWRDPAYRAVFGVAEPAGAAP"
     gene            complement(9884..9994)
                     /locus_tag="KLI87_RS25710"
                     /old_locus_tag="KLI87_25710"
     CDS             complement(9884..9994)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033212.1"
                     /locus_tag="KLI87_RS25710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25710"
                     /product="SapB/AmfS family lanthipeptide"
                     /protein_id="WP_156215438.1"
                     /transl_table=11
                     /translation="MALLDLQGMVSENGGGGGNSSLSLLCHSSHSYTICL"
     CDS_motif       complement(9938..9994)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MALLDLQGMVSENGGGGGN"
                     /locus_tag="KLI87_RS25710_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(9884..9937)
                     /prepeptide="core"
                     /locus_tag="KLI87_RS25710_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="7.00"
                     /molecular_weight="1725.0"
                     /monoisotopic_mass="1723.9"
                     /core_sequence="SSLSLLCHSSHSYTICL"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MALLDLQGMVSENGGGGGN"
                     /leader_location="[9937:9994](-)"
                     /alternative_weights="1743.0"
                     /alternative_weights="1761.0"
                     /alternative_weights="1779.0"
                     /alternative_weights="1797.0"
                     /alternative_weights="1815.1"
     gene            complement(10001..12559)
                     /gene="lanKC"
                     /locus_tag="KLI87_RS25715"
                     /old_locus_tag="KLI87_25715"
     CDS             complement(10001..12559)
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="lanKC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iii: micKC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LANC_like"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012853928.1"
                     /locus_tag="KLI87_RS25715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25715"
                     /product="class III lanthionine synthetase LanKC"
                     /protein_id="WP_214619000.1"
                     /sec_met_domain="micKC (E-value: 2.9e-243, bitscore: 805.0,
                     seeds: 18, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.1e-11, bitscore: 40.1,
                     seeds: 54, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.7e-09, bitscore:
                     31.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKRYELYCLANKFFYDAPPTTRETAFEIGSRPLPEGWERMPGDE
                     WTVYVPPEQKAPLQGWKVHVTGCAESADKALAASFDYCVENGIEFKHLHGPGTLRMRNA
                     KYAPRGASGKLVTIYPSDEAELEAVLETLGERLAGLPGPYILSDLRIGDGPLYVRYGGF
                     AHRRCLDERGELVAALENGEGVLVPDRRNPVFSVPEWVTLPRCLEPHLAARGATTTTDL
                     PYRIEKALHFSNGGGVYQGIDTRTGEKVVLKEARPYAGLAADGADAVERLDRERRILEL
                     LDGVEGIPAARDSFTLGEHHFLVQEFIEGRTLNTFFAERHPMLDPEPEPGKVAAYTAWA
                     LRVHEGVERVVRAIHERGIAFNDLHMFNVMVRPDDTIALIDFEVAAPAADGGRQTLANP
                     AFIAPPDRRGTAVDLYSLACLRLALFVPMTTLFVIDRGKARQLADLVAEYFPVPRPFLD
                     EAVAEITRGVPEVPAPAFEPDAGGWERARSSLSDAILASATPERDDRLFPGDVEQFSGA
                     ALGIAHGAAGVLYALEVTGAGRHPAHEEWLAERAADPPRGTGLGLYDGLQGAAYVLARL
                     GHLDAALGAVGHCLNERWERLGDDLYGGLPGYALVLSHLADLTGDTALEDAARRAVEIV
                     ADRAPQEKSPRPGLLYGGAGTALMFVRWYERTGDKALLDLAGTALRRDVAACVTDGNGA
                     LHVDQGHRVLPYLGRGSVGIGLVVDDYLAHRPDDPEFEKVRASVRLAAMSRYYAQPSLF
                     SGRAGMLLYLAGQDRDDPRVARHVRDLAWHALPYEGGLAMPGEHMYRLSMDLATGTAGV
                     LLALGAALHEAPARLPFLGTAPVPPVETSTAATSIQPERR"
     misc_feature    complement(12601..12617)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.04"
                     /tool="antismash"
     misc_feature    complement(12604..12613)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.29"
                     /tool="antismash"
     gene            complement(12740..13585)
                     /locus_tag="KLI87_RS41635"
                     /old_locus_tag="KLI87_25720"
     CDS             complement(12740..13585)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657776.1"
                     /locus_tag="KLI87_RS41635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25720"
                     /product="nitroreductase/quinone reductase family protein"
                     /protein_id="WP_214619001.1"
                     /transl_table=11
                     /translation="MTNEFNRRIIEEFRAKDGRVGGPFEGGRLVLLTTTGARTGARHTT
                     PLAYLPDAGQRIHVIASAGGAPRHPAWYRNLLADPRATVETGLFTYEARAAVLDGAERD
                     AVFARAVEADPGWAEYEAAASRTLPVVALDPAVEGPPQVAGGPAAQLVRVHDAFRRELE
                     LIRTEVARSGATIGAQLRVNCLALCEGLGNHHAGEDQMLFPVLAERYPGLGEALEVLRD
                     EHRVIERLLEDLRAVLAAPSSGSAALAAEVERLTADLEAHLDHEEERLVQALAQLTPDL
                     "
     misc_feature    13581..13596
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: strong,
                     score: 18.33"
                     /tool="antismash"
     misc_feature    complement(13649..13664)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.25"
                     /tool="antismash"
     misc_feature    13859..13875
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 16.08"
                     /tool="antismash"
     gene            complement(13901..16834)
                     /locus_tag="KLI87_RS41110"
                     /old_locus_tag="KLI87_25725"
     CDS             complement(13901..16834)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012888297.1"
                     /locus_tag="KLI87_RS41110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25725"
                     /product="AAA family ATPase"
                     /protein_id="WP_308166169.1"
                     /transl_table=11
                     /translation="MLIGRAAQLAELTAVLDRAAAGSAGVALVSGDAGVGKTHLVTALT
                     RAARDRGCAVLVGQCAELGESMPYLPLADALWTSARAAAPEAAAVRAALEARPVLGLLL
                     PDGEGAPGAASEVGQQQLFGAVLGLLGELGRERPVLLVLEDLHWADRSTRHLLTFLSRV
                     LQRERVCLVGTYRSDDLHRRHPLRPVVAELLRLPNVTGVEVAPFGPGETADYLAALAGG
                     TAPVTAEVVERVHQRSEGNAFYAAELYSAESTGEELPAGLADLLLSRVERLSEDAQRVV
                     RVAAVAGRRVDDELVRRVSGLDEASAGEALREVVSHQLLVPAGTGYSFRHALLREAVYA
                     DLLPGERTRLHAGFAELLSGEAAARRGSAAELAAHSLAAHDLPAAFAASVRAGREAERL
                     GAPAEAFEHFDRALELWDTVPEPEAVAGTDRMELSLATVRMSGRAGELRRAVSRLRRLL
                     DLADPADIALGVRLREQLASYLLDIDEDDEAVVVGRAAVALLEPGTPGPVRAAALATYA
                     RMLLYNDPDAEMPRLAEEAVVEARAAGARDAEASLLVTLGLYRESREADEAVAEVFASA
                     RDLAAAEGNQPAALRAAFQHARTKFDRGDLAGATLAADEGVKLALDNGLEWSSFGTVLR
                     SLQYLIHYTAGDWDEAARLAEGFAVRVVRPPEARVSAYALFLEVARGEPRVEERLRWIA
                     PLWHEDYFIAYVARGLAAEHELWRGGVDAAIEHVTAVLGVMYPFETGIIRIAATGLWAQ
                     ADRAARARAAGDPATVEDAARVGDDLLARARHVAATTWGDHPRAWLGLEGHAWLARAEA
                     ERSRLDGGHDPEPWRRSAELFTYGGDGFTYEVARSRYRLVEALVERGERAEAAEPWRSA
                     VAIAERLGAAPLLARLRELGARARLDPGRPGPGPGRANGSAGPFAALTVREREVLKLVA
                     EGRNNREIAAALFISPKTASVHVSNILAKLEVTSRTQAAAFAHREGL"
     gene            complement(17149..18411)
                     /locus_tag="KLI87_RS25730"
                     /old_locus_tag="KLI87_25730"
     CDS             complement(17149..18411)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045: glycosyl transferase group 1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634316.1"
                     /locus_tag="KLI87_RS25730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25730"
                     /product="glycosyltransferase"
                     /protein_id="WP_214619003.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.2e-22,
                     bitscore: 75.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHRPLNIALVSASDLDGEHAHSVHVRDLARSLARPRPGDEDTNHV
                     TVYTRRQDPSARARGRLGPGAALVQLDAGPARPHTEAEQLDHVRDLADGLRRRWSGSSR
                     PDVVHAHGWIGGLAACAVARELGIPFFQSFHGVAATERRAGREVHPHRDRLEKAIGRGA
                     DLVLASSVEEAATIVRMGVPRPSVKVVPYGVDADTFAQVGPAMPHGGRDRLVMVCRDLA
                     AGDVETALRALVHVPDAELAVAGGPDREDLENDPVVHRLMLLAKELHVADRVLFLGRLP
                     RKALPKLLRTARLALCLAPAQPSPAVPLEAMACGVPVVATPAGGNGDEVLDKITGLHVP
                     AGRPVVIGRTIRRLLAEETTLHGYSIAAADRARSRYSWDRIAGETLRAYAKALPEPDPV
                     PAPRAADEAECEADRTPAMAG"
     misc_feature    18512..18528
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 15.44"
                     /tool="antismash"
     gene            18599..19285
                     /locus_tag="KLI87_RS25735"
                     /old_locus_tag="KLI87_25735"
     CDS             18599..19285
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017624585.1"
                     /locus_tag="KLI87_RS25735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25735"
                     /product="histone deacetylase"
                     /protein_id="WP_214619004.1"
                     /transl_table=11
                     /translation="MDDEPVWYVAYGSNLFRERFRCYLSGGRPSGGARHYPGCRDPRPA
                     RAAAPVTLPGGIYFASTSPTWGGGMAFYDPGLPGRAAARAYLLSRRQFCDVVSQEMWRD
                     TGVDVDLTEAVRTGRQRLGPGRYETVLRVGERAGHPMLTFTAPAPHGPAELNAPAAAYL
                     GMLGNGLREAHGWTAARAASYLCGRPGAAGTWRPEKVAALISGPGRPEAGPPTGARGSA
                     APPGRR"
     gene            complement(19209..20855)
                     /locus_tag="KLI87_RS25740"
                     /old_locus_tag="KLI87_25740"
     CDS             complement(19209..20855)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019634324.1"
                     /locus_tag="KLI87_RS25740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25740"
                     /product="CocE/NonD family hydrolase"
                     /protein_id="WP_308166170.1"
                     /transl_table=11
                     /translation="MVSVGMMRRLGVTALGLRNGPHRVRVERDLEVPAADGVTLLADRY
                     APADVERAPVVLVRSPYGRRGPFGLMCGQAFASQGFQAVVQSARGGFGSGGVFEPLDER
                     EDGLATIAWLREQEWFGGAFAMHGPSYLGYVQWAVAAEAGPALKALSMQVTASTFRDAV
                     NVGGAFALESALIWVDLTARMKHSLSGITTGIMSPRRARRAALSGRPLAELDRLATGAQ
                     QRFFQELLANGADTPFWDRRDFSATVSRVDAPVNMTGGWYDIFLPWQLRDYAALRAAGH
                     RPYLTIGPWFHADQRMMRGSVGEAVKWFRAHLLDDPSQLREQPVRLFVTGAAEWREFPD
                     WPVPGMAEERWHLQPDGALAPAGPPESDPDSYRYDPRHPTPFLGGPTLLGETRPSTDQR
                     RLERRRDVLTYTSAVLEEDLEIIGPVAADLRVRSNREHTDFVVRLCDVAPDGESLNLCE
                     GMRRLVPGAPEAGADGVRRVAVELWPAGHRFRRGHRVRVQVASGAYPRVARNPGTGEPI
                     GTATAMLTADQEVLHSPAHPSAVLLPVVPAR"
     gene            21002..22066
                     /locus_tag="KLI87_RS25745"
                     /old_locus_tag="KLI87_25745"
     CDS             21002..22066
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018657882.1"
                     /locus_tag="KLI87_RS25745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="KLI87_25745"
                     /product="mechanosensitive ion channel family protein"
                     /protein_id="WP_214619005.1"
                     /transl_table=11
                     /translation="MGDHLDWRRVIIAAIVMVAALGVAVALRMLTGRLFRRAGDTRWTW
                     DDLAARLIRDLAMPVAVLTGAWFAALVLHLPRGTLDVTARVLTAATILVVSLALARLIA
                     GSVTSIAMARQGVAANVTIFANITRVIVIGIGLLVMLQSLGVSITPLLGALGVGGLAVA
                     LALQDTLANLFAGVHVLASKTIEPGDYIKLSSGQEGYVVDINWRNTSIRTLSDNIEVIP
                     NQRFSDTILTNYHRPAQDMSLLIQARVPYEADLERVEKLVVEVGEGVMADVQGGVKDAE
                     VLVRFHTFAESSVDFTVILRTSEFGDQFAIKHEFVKRLHRRFREAGVETPYPRRRVTLD
                     EASGPDGRPVSPGL"
ORIGIN
        1 cctccagccg gtcgaccgcg ccgaggcact cctcccagcc gcgcgagacg aaccgccacg
       61 ggtcgcccga gccggaggcg cgccacaggt ccccgagcca gtccccgtga taggtcgtgc
      121 gctgctcgtg gcagcggtcg cggagcgcgc ccggcaggtc ggcgggcgcc aggccgtccg
      181 ccagccaccg gacggcgaac gcggtcagct cgctcgccgc gagcccggtc gggtgcccgt
      241 gcgtcatcgc cgcctggagc tgcgacgcgg cggcgcgcgt ctcgtcggtc agccccgggg
      301 ccagcccgac cggcgcgacc cgcatgttcg cgccgcagcc cttggagccg ggctgggtcg
      361 cctccgtcca cggcacgggc gccgcgaggc ggcggcacgc ggtcaggcag gtgttgcccg
      421 gcgccctggt gttgtccggg ctgtcgagcc actcgacgaa ccgccgccgc cacagcggct
      481 cgacccggtc ggcggtgagc ggcgggtcgg ccagcgcgtc cagcagggcg aggccgaccg
      541 cgatcgccat ctgcgtgtcg tcggtcacga gcgccgggtc cccctcgggg cgctcgggcc
      601 cgaggccgcc gaaccgctgc ccgatctgcg ccatcgagag gaactcggtg ggcgcgccga
      661 gcgcgtcccc gtacgccagc ccgaacatcg ccccgctggc ccgccgtgtc gtcgtcatgg
      721 gcggattgtc ccgtaggccc cgaccttgcc gagccggggc tacggggccc agtcgtgcgg
      781 cccgagcacg tagcccttcg gcgtcgagtg gaggtggttg acctcgacga ggtgcccgag
      841 cgccgcccac agctcctcct cgggggccgc gacgaggcgg ctcaccgtgt cgaagtccgc
      901 cgccccgccc cccttgtcga tctccgcgac cgtctcgtag acggccagct cgaactcgct
      961 cagctcctgg acgtccccgc gcctgccctc tcgctcatcc atgaccgcag cctgcccact
     1021 gggcgcgggt ctagccgtag cggcgcatct cgtggaagaa ccccggcacc gtgctcagcg
     1081 cgccggacgc ggcgacctcg tcgtagacgt agcgggccac ggcgaggtcc aggacgccga
     1141 ggccgaacgg cgagaacacg atcggccggt cggcgggcgg ctcgatcgcg ccggtgagga
     1201 cgtcgtagag cgtcccggcc acgaagtccc gcccgccggt cttctgctcg gccaggtgcg
     1261 gggacgtgcc ggccttcagg cagtgctcca cgtcgtccac cacgttccac gccgacagga
     1321 tgatctcggg ggacaggtcg cgcagcgaga cgtgcaggac cagcgggttg tgcgcgaacc
     1381 acgccgggtc ggtgacgtgc ggctcgcccg cgacggtcgc gaacacgacg aggtccgacg
     1441 cgcggacgag gtcgtgcgcg gacccgtgga tcgtgacggt gcccggcccc gcgccctcca
     1501 ggtagccctt gaacccctcg gcgtgctcgg ccgacaggtc gtggacgccc agctcgtcga
     1561 acgcgaaccc gttgcccgcc aggtaggtgt ggatgtagcg ggcgatcagc ccggtgccga
     1621 cgaacccgac ccggcgcggg cgctcgccgc gcaggtcggc gagcgtgacc gcggccagcg
     1681 cggcggacgc ggcggtccgc gcggccgaga tgatcgagct ctccaggcac gcgaacgggt
     1741 agccggtctc ggcgtcgttg aggatcagca cggcggacgc gcgcgggatg cccgccgcga
     1801 cgttgccggg gaagctggag atccacttga tgccgtgcac gccgatctcg cccttgaccg
     1861 acgcgggcag cgcgatgatc cggtcggacg gccggtccgg gaagcgcagg aagtaggagt
     1921 cggggttcac ggtctgcccc tcgccgtgca gccggtaggc cgcctcgacg gtccgggtga
     1981 cccgctcctc gtgcccgccg atcacctcgt gcacctgcgc tccggagatc acggcgaatg
     2041 tgggggcctg cgtcatgggg gaactcccgt ccgtcgagat gatcttcgag ccgaggataa
     2101 ccgtgccccg ggcaccgccg ccccgccccc cgggacaggg ccttagggtg gcggcggagg
     2161 ccgccccgcc cggggccgcc gcgcccccgc ccgagatcgt ctcgtccccg ccgggacgag
     2221 gaggaggagt cgagcacatg acctggttcc gctgcgccga gacccggccc tgggcgtcga
     2281 cgcggctgtt ctgcctgccg cacgcgggcg ggtcggcggt gtcctaccgg tcctggacga
     2341 aggaggccga cccctcggtg gaggtgcgcg ccgtccagta cccggggcgc gccgaccggc
     2401 tggccgaccc cctcgtcggc gatgcccacg agctggcccg gctcgtcgcg ggcgcgatgg
     2461 ccccgctgct cgaccggccc gccgcgctgt tcgggcacag catgggcgcc gtcgtcgcct
     2521 acgaggtcgc tcggctgctc caggagcgcg ggagcgcgcc cgtccacctg ttcgcctccg
     2581 gcgcccggcc gccgcacgac cggggcgatg accgcgtctc cgaccgcgac gacgagggcg
     2641 tgctcgccga gatgacgcgg ctcggcggca ccgacgccga gatcctggcc gacccggagc
     2701 tgcgcgagct ggtgctgccc tacgtccgca acgacttcgc gctggtcgag aactacgcgc
     2761 acctgccggg cacgcggctg gaggtcccgg tcaccgtgat cgtcggggac gacgacccgc
     2821 acgtgacccc ggcgcaggcg cggcggtggg cggagctgac cgacgggccc ttcgcgatga
     2881 cggtgatgga gggcggccac ttctacctca ccccccacca gtccgccgtg atcgccgaga
     2941 tccaccgggc gctgggcgtc gcgggctgag ggcctggcgg gccgaccccc gcccggacgc
     3001 gcgcgagccc ccgggccccc gccgggcgag gcgggggacc aggggcccga tcccgggcgc
     3061 gcaggccgga aggccgtcgc ggggccggag cgtcagtaca cctgggcgcc gtatacctgg
     3121 agcggctcgg tgaccggctg gaagaacgtc gtgccgccgc tggagcagtt gccgctgccg
     3181 cccgaggtca gcccgagcgc ggtggccccg gcgaacagcg agccgccgct gtcgcccggc
     3241 tccgcgcaca ccgtcgtctt gatcaggccg gtgacgctgc cctcgcggta gttcacggtc
     3301 tggttgagcc cggtgacctg gccgctgtgc acctgcgtgg tgctgccgct gcgctgcacg
     3361 gtctgcccga cggtcggggt cccggcgctc gtgatgtcct ggctgccgcc gttgtagagg
     3421 ctgaccgagc cctgggtgtc ctccggggtg gaggagtact tcacgatgcc gtagtcgttg
     3481 cccgggaagc tgccgttctc ggtgttgccg agcagcctgg tcttgccctg gtcggagtac
     3541 cagctcgtgc cgatgttcgt gcagtgcccg gcggtgagga agtagtacgc gccccccttc
     3601 ttgacgttga agccgagcga gcagcgcccg ccgctggtcc agatggcctc gccgccccgg
     3661 gtgaacgtgc ggaacgtccc ggcgacccgc tcggtgcgga cggcggcgcc ctgcttggcg
     3721 acggcccggc gcaccttcgc gagcccggcg ccggtgaccg aggagtccat ggacagcacg
     3781 accttgttac tggccgggtc cgcggcccac gcggtgcccg ggacggtcgc gtcgcgcttg
     3841 agcgcggcca tgacgcgctt gaggtccgcg ccgctgcgcg cgacggtctt cggctgggcg
     3901 cccgccgcgc ggacggcccg cgccgcgctc gcgtcggtga ccgtgaccac gagctgccgc
     3961 gtggcggcgt cgatgtagga gccggcgctg cgggagccga gccgccgggc cagcgtcgcg
     4021 gccgtcctgg cctgcgccgc ctgggctgtc gtgacggcgc cggccggtgc ggccggcgcc
     4081 tgcggggccg cgttcgcggt gggggcggcg accagggcgg acgccatgac tcccgtcgcc
     4141 gtcatcgtga cggccgcgcc gctgatgcga gcgtgacgga tcttcactga gcctccaggg
     4201 gggagcgggc acacccggat tggtatgccg gaggtcaccg cacatgctcc gagaccccaa
     4261 gggcggacgg aaggctagaa agtgcccaat cagcggagac tgccttggca caatgggtgc
     4321 ggatttgtct agccgtcacg ggcaggatgg cctgttaagg acaattagct cgcaccaggt
     4381 atggggcctg ccgtggggcg ggtaggacgt tgcggcaaaa tgatcaggtg acgttgctgc
     4441 tgaccaggtc cgatctggag tccgtgctcg atcccgcggc ctgcctcgcc gagctgcgcc
     4501 gcggattcac cgcggggagc gcgggcgggg acgcggcgcg ccgcgtcgtg gcccgcccgc
     4561 cgggccccgg gaccgcgacg gcgctgctgc cgggcgcggt cgagggcatc cccgcctaca
     4621 cggtgaaggt caacgccaag ttcccgggca gccgtccggc gctgcgcggc gtggtgtgcc
     4681 tgcacgacct cggcaccggc gaactgctcg cgctgctgga ctcggccacc gtcaccgcgt
     4741 ggcgcaccgg gctcgccgcc gcgctcggca cccacgtcct cgcccgtccg ggcgccgacg
     4801 cggtcgcggt ggtcggggcc ggggcgcagg cggagttggt gatgcgcggg ctcgcggcgc
     4861 tgcggccggt gcgccggctc gcggtccacg acctggacgc gggccgggcc gaggcgttcg
     4921 ccgcgcggca cggcgccctg ctcgggctgg acgcctccgc cgcggcctcc tacggcgcgg
     4981 ggccggacgc cgtccgcgag gccgtgcggg acgcgggcat cgtcgtgacg gcgacctggg
     5041 cgcgcagccc gatcctggac gcgccggacg tcgcgcccgg cgcgcacgtc acctccctcg
     5101 gcgcggacga gccgggcaag gccgagctgg cgcccggcct cctgcgggcg gcgcgcgtcg
     5161 tggtcgacga cgtcgcgctc gcggcggaga tgggggcgct ggccggtgcg ggccccgagg
     5221 tggaacggtc cgccgcgacg ctcggggacg tgctggcggg ccgggcgccc ggcagggcgg
     5281 cggaggacgg gcgcaccgtc tacgcgccgg tcggcctgcc ctggcaggac ctcgccctga
     5341 gctgggccgc ctttaatatg gcccgttcca atcaggtagg gctggcgttc gatttcctcg
     5401 gttgaactgg ccgactgcgg acagcggatt ctttcgacaa aatcacgcac ggtaattgtt
     5461 aatattctat ttcgtcttta tgctgactcg acgattactg ttggctccgt tcggtaggtc
     5521 ccgctcatga gatcggttcg tctagacgtg tcgaaggaag agcctcatcg tgagccccgt
     5581 gcctcgggac ccccggctcg gtcaccgcct ctttcttctc ataggttgac aaacggtggg
     5641 taagtgcttc tcgggccaca tgggtggcgg gccttgggag acagaacatg attcggatac
     5701 tcctcgccga ggaggcgccc ctcctgcgag gcgggctggt cgcgttcttc ggcggtgtga
     5761 aagacctgga cgtcgtggcc gcgatcgatt ctggtgatca tttgctgcgc atggcgaatt
     5821 tacggaggcc ggacgtcgca ttgatagacg tcgcgcttcc gggactggac ggcttctcgg
     5881 cgtcccggag gctgcgggag gaactccccg actgccgcac cgtgctcatg tcgggccggc
     5941 accgcaccgg cgacctgcgc cgggcggtca ccgcccgggc ggcggggctg gtcctgaagg
     6001 acacctcgcc cggcgcgctg gtggacgcga tccgccgggt cgccgacggg cagcgcgtcg
     6061 tggacgccga ggtggccttc agcgagctcg gctcggcggt gagcccgctg accgagcgcg
     6121 agagcgaggt gctggagctg gcctcacgcg gggcctcggc ggcgcagatc gccgaggacc
     6181 tcgtcctgac gatcgggacg gtccgcaacc acctctcccg catcaaccgg aagatcggcg
     6241 cgcggaaccg ggtgcacgcg atcaggatcg ccgaggaggc cgggtggctg tgagccgccc
     6301 ggcccctcgg ggtctgccgt gcccggcccc tccgggcccg ccgtgccggg cgcctcgggc
     6361 gagggccggt ccgggtcccc cgactcccag cggccgatga ggtcgcggta gaggggggag
     6421 acggcgggca ggtccgcgtg ccggccgacc cgcgcgtgcg tcccgtccag caccaggacg
     6481 cggcgcgcgc gcaccgccga gctgacccgg tgcgcgatga cgacgagcgt cccggggcgg
     6541 cgcgcgaacg cctcctccgc gcgcgcctcg gcggcggcgt ccagccggca ggcggcctcg
     6601 tccagcacga tcagcggcgc gggcgccagg taggcgcggc acagcgcgat gagctggcgc
     6661 tgcccctcgg tcagcgccgc cgggtccacg gtcgcgccgt agccgccgag gtcccggacg
     6721 agccgcgcca gcccgagctc gtccgccgcg cgcacgacgt cctcgtcgcg ggcgtcgggc
     6781 gcgaggtagg tcaggttctc gtggacggtg ccggtgaaca cgtacgcctc ctgcgggatg
     6841 agcacccgcg cggccgggtc gcccgccggg cggcccgcca ccagcacctc gccctccagc
     6901 ggcgccagca ggcccgcgac gagcgccgcc agcgtcgact tgccgatgcc gctcggcccg
     6961 acgaccgcga ggtggtcgcc gcgcgggatc gtgaggtcca ggccgctgat caccggccgc
     7021 gccgaggcgc cgtaggcgaa ggtgacgccg cgcagctcca ccgccggcgc gtccgcgcgc
     7081 tcctcgcggg gcgcctcggc cacggggggc aggggcggcg cgacgggggc gctcgtctcc
     7141 aggatccggc cgagcgtcac cgcgagccgc aggccgctgc cgcccatgcc ctgcacgagc
     7201 gtccgcagcg cgggctgcag cccgtgcagg acgtaggcga gcgcgccgac caccatgccg
     7261 ggggtcgcgc cgcgccgcat cagccacggc gccgccgcga gcacgaccag cagcggcagc
     7321 cagccgctca ccgcgagcgc cagcgcccgg accgccgcga accgcgcgac cgcccggccc
     7381 gccgccgcct gcgcgtcgac cgccgccgcg agccgctcgc gcacctggtc ctccgcgccg
     7441 cacgcgacga cgtcccgcag cccctcggcg agcgcggtgg tccgctcggc gatctcctcc
     7501 tcgccgacga cgagggcgcg ctgccggatc gccgccgccc cgaacgcggc gccgaacagc
     7561 accagccccg ccaccagcgg cggcagcacc agcagcgtca cctcgggcat cagcgtcgcc
     7621 agcccgagca gcgcggcgcc cgccgcgaac acgaacccgc gcgcgacgac gaggatgccg
     7681 ccgaaggtgt cccggacgat ctccacctgg tgcgtgagcc gcgcgaccgc gcccgtgtcg
     7741 ggacggccgc gcagcgaccg gtacagcgcg ccccgggtga ccgcgcggac caggtcgtct
     7801 cggaacggct cgacgagcgc ggcgagcgcc aggtagaggc ggcggctccc gtaggcgccg
     7861 acgaccgccg cgaccgccag cgcggcgagc caggcggccg cgcgcaccgg gcggtcgtcg
     7921 atgaaggcgt cggtggcctg cgccacggcc cgcccgaaca cggcggtggg cacggcctcc
     7981 agcagcgacc aggcgaggac ggcggacgcg gcgcggggcc gcccccgcac ggcgcccgcc
     8041 gccgtccgcc acagcagccg cgcggcctcg cgcctggacg tcatgactcg cgcccggagg
     8101 tcatggtgcc gccccggcgg gctcggccac cccgaacacg gcccggtagg ccgggtcgcg
     8161 ccacagctcg gcgtgcgtcc cgcggccgcg gacccggccg ccgtcgagcc agaccacgag
     8221 gtcggcgcgg gcggcggtgc ccgcgcggtg cgcgatgatc agccgggtcc ggtcgccgaa
     8281 gcggtccagc acggcgccgg tgacctgcac ctcggtgacg gtgtcgaggc tggaggtcgc
     8341 gtcgtccagc acgaggacgc ggcccgcgtg cgcgaacgcg cgggcgaggc ccatgcgctg
     8401 cagctcgccg cccgacatcg gcgcgtccgc gagcggcgtc gcgtagccct gggggaggcg
     8461 gcggacgaag tcgtcggcgc acgccgtgcg ggccgactcc cgcagccacg actccggcgg
     8521 gcggcacggt ccgaacgcga tcgcgtccag gaccgtctcg ccgaacagcg tcgggcgggc
     8581 gaaggcgtac ccgacgtggc ggcgcagctc ggtgcgggcc aggcggggga gcggcgcccc
     8641 gtcgagcagc acctcgcccc ggtcggggtc ggcgaggcgc ccggcgagcg cggcgagcag
     8701 cgacttgccc gcgcccgagc gcccgacgac cgcgacggcg agcccgccgg ggacggtgag
     8761 gtccaggccg tggagcacgc cgccggccga gaccccccgg aactccaggg tgccccgtcc
     8821 ctccgggacg gcggcgtcgc cgtcggcggg ggcgggctgc tccaggatct cggcggcgcg
     8881 gcgggccccg gcgcgcgccc ggccgagccg cagcacatgg gtgaggacgg ggccgaaacc
     8941 ggccgcgagc cccgcgtact ggacggtcgc gacgagctcg ccggcggtga cgcggcccgc
     9001 catcagctcc gcgcccgccg cgccgacggc ggcgacctgg agcagcagca gcgtcagcag
     9061 gccgcgcgcg gccacgccgc cctgcaccgt ccacatcgtc tcgccttcgg cgcgcaggcc
     9121 gggcagcggc cgcaggaccc gttcggcctc ccgctcggcg gtgccggcgg cggcgatcgt
     9181 gcgggccccg gcgagcgcct cggcgagccg tccggcgatc gtcccctgca cgctcaggta
     9241 gcggtgggcg gacgcggtga tgtcgcggac gaacacccgc agcagcagca cgatcgccgg
     9301 gagcgcgacc gcgacggcga ccgcgagccg ccagtcgatg aaggccagca cggtgagggc
     9361 gccgagcggc ggcagcagcg cgacggcggc ctcgggggcg gcggacggcg cggtccccgc
     9421 ctcggcggcg ccgccgacgg tgcgtccggc gacgtccccg ggcgggacgc gcagcgcggg
     9481 gccgacggcg aggacatggc ggacgagcgc gtgccgcagc caggccgtcg cgcgcgccgc
     9541 cgagcatccg gtggcgagtt ccgacagcac ctcggcggtg gccgacagca ggacgagcgc
     9601 gacgcacggc cacagcgcgg acgcggcgga cgggccgccc ggcggggcgg cgtcgacggc
     9661 gcgggcgagt gcgaggggga gcaggacggc ggcgagggcg tcggccaccg cggtggccgc
     9721 gacgagcccg gtccagccgc cgctgtgccg ggcggcgccg accagcaggc ggtccgctcc
     9781 ggcggtcgtc ggagaggtca tgggttcggt gccatcatgg gtctcccgcg atgaacggcc
     9841 atggtcctcc ccagtgggcg gaccatggcc gtcaccgttg ccgttacagg cagatggtgt
     9901 agctgtgcga gctgtggcag agcaggctga ggctgctgtt accgccgccg ccgccgttct
     9961 cgctcaccat tccctgaagg tcaagaagcg ccatttgtct tcacctcctt tcgggctgga
    10021 tagaggtggc cgccgtggag gtctccacgg ggggaacagg ggccgtcccg aggaacggca
    10081 accgggccgg ggcctcgtgc agcgccgcgc cgagggcgag cagcaccccg gccgtgccgg
    10141 tcgcgaggtc catcgacagc cggtacatgt gctcgccggg catcgccagc ccgccctcgt
    10201 agggcagtgc gtgccaggcg aggtcgcgga cgtggcgcgc gacgcggggg tcgtcgcggt
    10261 cctggcccgc caggtagagc agcatcccgg cgcggccgct gaacaggctc ggctgcgcgt
    10321 agtaccgcga catcgccgcc agccggaccg acgcgcggac cttctcgaac tccgggtcgt
    10381 ccgggcggtg cgcgaggtag tcgtccacga ccaggccgat gccgacgctg ccgcgcccga
    10441 ggtagggcag gacgcggtgg ccctggtcga cgtgcagggc gccgttgccg tcggtgacgc
    10501 acgcggcgac gtcgcggcgc agcgcggtcc cggcgaggtc cagcagcgcc ttgtcgcccg
    10561 tccgctcgta ccagcggacg aacatcagcg ccgtcccagc cccgccgtac agcagtccgg
    10621 ggcgcgggct cttctcctgg ggggcgcggt ccgcgacgat ctcgacggcg cggcgcgccg
    10681 cgtcctccag tgcggtgtcg cccgtcaggt ccgcgaggtg ggacagcacc agcgcgtacc
    10741 cggggagccc gccgtagaga tcgtcgccga ggcgctccca ccgctcgttc aggcagtgcc
    10801 cgaccgcgcc gagcgccgcg tcgaggtggc cgaggcgggc gaggacgtac gcggcgccct
    10861 gcaacccgtc gtagaggccg aggccggtac cgcgcggcgg gtcggcggcc cgctcggcga
    10921 gccactcctc gtgcgcggga tggcggccgg cgccggtcac ctccagtgcg tacaggacgc
    10981 ccgccgcgcc gtgggcgatg ccgagcgccg cgcctgagaa ctgctccacg tcgccgggga
    11041 acagccggtc gtcccgctcg ggggtggcgc tggcgaggat ggcgtccgac agggaggagc
    11101 gggctcgctc ccagccgccg gcatcgggct cgaaggcggg cgcggggacc tcggggacgc
    11161 cgcgcgtgat ctccgcgacg gcctcgtcga ggaacgggcg cggcaccggg aagtactcgg
    11221 cgaccaggtc ggcgagctgc cgcgccttgc cccggtcgat cacgaacagc gtcgtcatcg
    11281 ggacgaacag cgcgagccgc aggcacgcca ggctgtagag gtcgacggcc gtgccgcgcc
    11341 ggtcgggcgg cgcgatgaag gcggggttgg cgagcgtctg ccggccaccg tcggcggcgg
    11401 gcgcggcgac ctcgaagtcg atgagcgcga tcgtgtcgtc cgggcggacc atcacgttga
    11461 acatgtgcag gtcgttgaag gcgatgccgc gctcgtggat cgcccgcacg acccgctcga
    11521 cgccctcgtg gacgcgcagc gcccatgccg tgtacgcggc gaccttcccg ggctccggct
    11581 cggggtccag catcgggtgg cgttcggcga agaaggtgtt gagcgtccgc ccctcgatga
    11641 actcctggac gaggaaatgg tgctcgccga gcgtgaagga atcgcgcgcg gcgggaattc
    11701 cctcgacccc gtcgagcagt tcgaggatgc ggcgctcgcg gtccagccgc tcgaccgcgt
    11761 cggcgccgtc ggcggcgagg cccgcgtagg ggcgcgcctc cttcaggacc accttctcac
    11821 ccgtgcgggt gtcgattccc tggtagacgc cgccgccgtt ggagaagtgc agcgccttct
    11881 cgatccggta cggaaggtcg gtcgtcgtgg tggcgccccg tgcggccaga tgcggttcga
    11941 ggcagcgggg cagcgtcacc cattccggga cggagaagac ggggttgcgg cggtcgggga
    12001 ccagcacgcc ctcgccgttc tccagcgcgg cgacgagttc gccgcgctcg tccaggcacc
    12061 ggcggtgggc gaaaccgccg tagcggacgt acagggggcc gtcgccgatg cgcaggtcac
    12121 tgaggatgta gggccccggc aggccggcga gccgctcgcc gagcgtctcc agcaccgcct
    12181 ccagttccgc ctcatcgctc gggtagatgg tgacgagctt gccgctcgcc ccgcgcggag
    12241 cgtatttcgc gttgcgcatc cggagcgtcc ccgggccgtg caggtgcttg aactcgatgc
    12301 cgttctcgac gcagtagtcg aacgaggcgg cgagagcctt gtccgcgctt tccgcgcagc
    12361 cggtgacatg caccttccag ccctggagcg gcgccttctg ctccggcggg acgtacaccg
    12421 tccattcgtc gccaggcatc ctttcccagc cttcgggaag ggggcgggat ccgatctcga
    12481 acgcggtttc ccgggtcgtc ggaggcgcgt cgtagaagaa cttgttcgcg aggcagtaaa
    12541 gctcatacct cttgtccacg acaacggtcc tctctgccgg atccggcggg cgccggtcac
    12601 aggtaaaaga atggcaaatg gccgggaagg gggctagtag ccgatataac gactcacccg
    12661 tgaagatgta ccggccgcgc gtgggcgttc gtcaccccgc gtccgcgtct cgtgaccgtg
    12721 cgcccgcctc gacctggcct tacaggtccg gcgtgagctg ggcgagcgcc tggaccagcc
    12781 gctcctcctc gtggtccagg tgcgcttcga ggtcggcggt caggcgttcg acctccgccg
    12841 cgagggcggc ggacccggat gagggcgccg cgaggacggc ccgcaggtcc tccaggagcc
    12901 gctcgatgac ccggtgctcg tcgcggagca cctccagggc ctcgccgagc cccgggtacc
    12961 gctccgccag gaccgggaac agcatctggt cctccccggc gtggtggttg ccgagcccct
    13021 cgcacagcgc caggcagttc acgcggagct gcgcgccgat cgtggccccg gacctggcga
    13081 cctccgtccg gatcagctcc agctcgcggc ggaacgcgtc gtggacccgg acgagctggg
    13141 ccgccgggcc gcccgccacc tgcggcgggc cctcgacggc cgggtcgagc gcgacgacgg
    13201 gcagcgtccg ggacgcggcg gcctcgtact ccgcccaccc gggatcggcc tcgacggccc
    13261 gcgcgaacac ggcgtcgcgt tcggcgccgt ccagcaccgc ggcccgcgcc tcataggtga
    13321 acaggcccgt ctcgaccgtg gcgcgggggt cggccagcag gttgcggtac caggccgggt
    13381 gccgcggcgc cccgcccgcc gaggcgatga cgtggatgcg ctggccggcg tcggggaggt
    13441 aggcgagcgg ggtggtgtgc cgcgcgccgg tccgcgcgcc ggtggtggtc agcaggacga
    13501 gccggccgcc ctcgaacggg ccgcccaccc gtccgtcctt cgcgcggaac tcctcgatga
    13561 tccgccggtt gaattcgttc gtcactctgg tgtctctcct ttttcgggca tgccgagttc
    13621 gccacgggac ggtgctcgac cgtggcgtgt cgaaaaaacg cggtaacgcg tgaagaaggg
    13681 cgcgcggaaa acgcgccgaa gcccggcgcg cgcacgggcg tgcggcaccg agaggaaaga
    13741 aggaaggggg cgcgaggtgc gcggataccg gcggaggcgg ggccctggcc ccggcgctca
    13801 cgtcctggcc gggtgcctca ctcggtagtg gcccatggcc gacccggcag tcacgaaatt
    13861 gatcctaaag gacatcggat tgccgtggca aggcgggccg ctaaaggccc tcgcggtgcg
    13921 cgaacgcggc cgcctgggtg cggctcgtga cctccagctt ggcgaggatg ttcgatacgt
    13981 gcacgctcgc ggtcttcggg gagatgaaca gcgccgccgc gatctcccgg ttgttgcgcc
    14041 cctccgcgac cagcttgagc acctcgcgct cccggacggt cagcgccgcg aacggcccgg
    14101 ccgagccgtt ggcccgcccc ggccccggac ccgggcgccc cgggtcgagc cgcgcgcggg
    14161 cgccgagttc gcgcagccgc gccagcagcg gggccgcgcc gagccgctcg gcgatcgcga
    14221 cggccgaccg ccacggctcg gcggcctccg cccgctcgcc gcgctcgacg agcgcctcga
    14281 ccagccggta ccgcgaccgc gcgacctcgt aggtgaagcc gtcgccgccg taggtgaaca
    14341 gctcggcgga cctgcgccag ggctcggggt cgtggccgcc gtccaggcgg ctgcgctcgg
    14401 cctcggcgcg ggcgagccag gcgtgcccct ccaggccgag ccacgcgcgg gggtggtcgc
    14461 cccaggtggt ggccgcgacg tggcgggcgc gggcgagcag gtcgtcgccg acgcgcgccg
    14521 cgtcctcgac ggtggccggg tcgcccgcgg cgcgggcccg cgcggcgcgg tcggcctgcg
    14581 cccacaggcc ggtcgcggcg atccggatga tgccggtctc gaacggatac atgacgccca
    14641 gcaccgccgt cacgtgctcg atcgcggcgt cgacgccgcc gcgccacaac tcgtgctcgg
    14701 cggcgagccc gcgcgcgacg taggcgatga agtagtcctc gtgccacagc ggcgcgatcc
    14761 accgcagccg ctcctccacc cggggctcgc cccgcgcgac ctccaggaac agcgcgtagg
    14821 ccgagacccg cgcctcgggc gggcggacga cccgcaccgc gaacccctcg gcgagcctgg
    14881 ccgcctcgtc ccagtccccg gccgtgtagt ggatgaggta ctggaggctg cggagcaccg
    14941 tcccgaacga gctccactcc aggccgttgt cgagggcgag cttgacgccc tcgtcggcgg
    15001 cgagcgtcgc gcccgcgagg tcgccgcggt cgaacttcgt gcgggcgtgc tggaacgccg
    15061 cccgcagcgc cgccggctgg ttgccctcgg cggcggcgag gtcgcgggcg ctggcgaaca
    15121 cctcggcgac cgcctcgtcg gcctcccgcg actcgcggta gaggcccagc gtgaccagca
    15181 ggctcgcctc cgcgtcgcgc gccccggccg cgcgcgcctc cacgacggcc tcctcggcga
    15241 gccgcggcat ctccgcgtcg gggtcgttgt agagcagcat ccgggcgtag gtggcgagcg
    15301 cggcggcgcg caccgggccg ggggtgccgg gttcgagcag cgcgacggcg gcgcggccga
    15361 ccacgacggc ctcgtcgtcc tcgtcgatgt cgaggaggta ggaggcgagc tgctcgcgga
    15421 gccgcacgcc gagcgcgatg tcggcggggt cggcgaggtc cagcagccgc cgcaggcgcg
    15481 acacggcccg gcgcagctcg cccgcccgcc ccgacatccg gacggtcgcg agcgacagct
    15541 ccatccggtc ggtcccggcg acggcctccg gctcggggac ggtgtcccac agctccagcg
    15601 cccggtcgaa gtgctcaaac gcctcggcgg gcgcgccgag tcgctcggcc tcgcggcccg
    15661 cccggacgga cgcggcgaac gcggcgggca ggtcgtgcgc ggcgaggctg tgcgccgcca
    15721 gctcggccgc cgacccgcgc cgggcggccg cctcgcccga cagcagctcg gcgaacccgg
    15781 cgtgcagccg ggtccgctcg ccgggcagca ggtcggcgta gacggcctcg cgcagcagcg
    15841 cgtgccggaa gctgtagccg gtgcccgccg ggacgagcag ctggtgcgag acgacctccc
    15901 gcagcgcctc cccggcggac gcctcgtcca gccccgacac ccggcggacc agctcgtcgt
    15961 cgacccgccg cccggcgacg gccgcgaccc gcacgacgcg ctgcgcgtcc tccgagagcc
    16021 gctccacccg cgacagcagc aggtcggcga gcccggcggg cagttcctcg ccggtgctct
    16081 cggccgagta cagctcggcg gcgtagaagg cgttgccctc cgagcgctgg tgcacccgct
    16141 cgacgacctc ggcggtcacc ggcgcggtgc cgcccgcgag cgcggcgagg tagtcggcgg
    16201 tctccccggg cccgaacggc gcgacctcga ccccggtcac gttcggcagc cgcagcagct
    16261 ccgcgacgac cgggcgcagc gggtgccgcc ggtgcaggtc gtcggagcgg taggtgccga
    16321 ccaggcagac ccgctcgcgc tgcaggacgc ggctcaggaa cgtcagcagg tgccgggtcg
    16381 agcggtcggc ccagtgcagg tcctccagca ccagcaggac gggccgctcc cggcccagct
    16441 cgccgagcag cccgaggacc gcgccgaaca gctgctgctg gccgacctcg gacgcggcgc
    16501 ccggcgcccc ctcgccgtcg ggcagcagca gcccgagcac ggggcgcgcc tccagcgcgg
    16561 cgcggacggc ggcggcctcc ggggcggcgg cgcgcgcgga ggtccacagc gcgtccgcga
    16621 gcgggaggta gggcatgctc tcgcccagct cggcgcactg gccgaccagg accgcgcagc
    16681 cgcggtcgcg ggcggcgcgg gtgagcgcgg tgacgaggtg ggtcttgccg accccggcgt
    16741 ccccgctgac cagcgcgacc ccggcgctgc ccgcggcggc ccggtcgagc acggcggtca
    16801 gctcggcgag ctgcgccgcc ctcccgatca gcacccggcg cccccggacg tcgcgtattc
    16861 ggccatgccg cacagtatcc caccggctgg aacacccgaa tacaccacac gacccccggc
    16921 cacgcccggc ccccggccac gagcggcccc tggccacgtg cggtgcctgg ccacgtgcgg
    16981 tgcccccgag cgtgcggtgt ctcgacgcgt gtggggccgg gtcgcgtgtg gggccgggtc
    17041 gcgtgtgggg tcgggacggc ggcggtggcc gggtgtgcct gtgggggccg gacatgagcg
    17101 ggccccggat ccggggaggg atccggggcc cgccggtgac ggggcgcgtc aaccggccat
    17161 ggcgggtgtc cggtcggcct cgcactccgc ctcgtccgcg gcccggggcg ccggcaccgg
    17221 gtcgggctcg ggcagcgcct tggcgtaggc gcgcagggtc tcgccggcga tccggtccca
    17281 ggagtagcgg gagcgggcgc ggtcggcggc ggcgatggag tagccgtgca gggtggtctc
    17341 ctcggcgagc aggcgccgga tcgtccgccc gatcacgacg gggcggcccg ccgggacgtg
    17401 cagcccggtg atcttgtcga gcacctcgtc gccgttgccg cccgccgggg tcgccacgac
    17461 cggcacgccg caggccatcg cctccagcgg caccgccggg gacggctggg cgggcgccag
    17521 gcacagcgcc agccgggcgg tgcgcagcag cttgggcagc gccttgcggg ggaggcggcc
    17581 gaggaagagc acgcggtcgg cgacgtgcag ctccttggcg agcagcatca gccggtggac
    17641 gaccgggtcg ttctccaggt cctcgcggtc ggggccgccg gcgacggcca gctccgcgtc
    17701 cgggacgtgc acgagggcgc gcagcgcggt ctcgacgtcg cccgccgcga ggtcgcggca
    17761 caccatcacg agccggtccc ggccgccgtg cggcatcgcc gggccgacct gcgcgaacgt
    17821 gtcggcgtcc acgccgtagg gcacgacctt gaccgacggc cggggcacgc ccatccgcac
    17881 gatcgtggcg gcctcctcga cgctggaggc gagcaccagg tcggcgccgc ggccgatggc
    17941 cttctccagc cggtcgcggt gcgggtgcac ctcgcgtccg gcgcgccgct cggtggcggc
    18001 gacgccgtgg aagctctgga agaaggggat gccgagttcg cgggcgaccg cgcaggcggc
    18061 caggccgccg atccagccgt gcgcgtggac gacgtcggga cggctggagc cgctccagcg
    18121 gcggcgcagc ccgtcggcga ggtcgcggac gtggtcgagc tgctcggcct cggtgtgggg
    18181 ccgggcgggg cccgcgtcga gctggacgag cgcggcgccg gggccgagtc ggccgcgggc
    18241 acgggcggac gggtcctgcc gccgggtgta cacggtgacg tggttggtgt cctcgtcgcc
    18301 tggacgcggc cgggcgaggg agcgggcgag atcccggacg tggacggaat gcgcgtgctc
    18361 gccgtcaagg tcggaggcgg acacgagcgc gatgttcagc gggcgatgca tgacgatcct
    18421 ccgggacaac acaggggaag cctggaggta tctgcgtctt agacacctgc tcgctggaga
    18481 ctatttccgt ctgcccggtc cgtcaaacct cgcgaaacgg gatcacatcg ggtcaagggc
    18541 ggcgatcaag ccgtgaccag cgaggactcc tcactatacc gtcggcgata ctggaggcgt
    18601 ggacgacgag ccggtctggt acgtggccta cgggtcgaac ctgttccgcg agaggttccg
    18661 ctgctacctg tccggggggc gcccgagcgg cggcgcccgg cactaccccg gctgccgcga
    18721 cccgcgtccg gcgcgcgcgg cggcgccggt cacgctgccg ggcgggatct acttcgcctc
    18781 gacctcgccg acctggggcg gcggcatggc cttctacgac ccggggctgc cgggacgcgc
    18841 cgccgcccgc gcctacctgc tctcgcgccg ccagttctgc gacgtggtct cccaggagat
    18901 gtggcgcgac accggcgtcg acgtcgacct gaccgaggcg gtgcgcacgg gccgccagcg
    18961 gctcggcccc ggccgctacg agaccgtgct gagggtcggc gagcgcgccg ggcaccccat
    19021 gctcaccttc accgcgcccg cgccgcacgg ccccgccgag ctgaacgccc cggccgccgc
    19081 gtacctgggc atgctcggca acgggctgcg cgaggcgcac ggctggacgg cggcgcgcgc
    19141 cgcgtcctac ctgtgcgggc ggccgggcgc ggcgggcacg tggcggccgg agaaggtggc
    19201 ggcgctgatc agcgggccgg gacgaccgga agcaggaccg ccgacgggtg cgcgggggag
    19261 tgcagcacct cctggtcggc ggtgagcatc gcggtggcgg tgccgatcgg ctcgccggtg
    19321 cccggattgc gcgcgacccg ggggtaggcg ccgctcgcga cctgcacgcg gacccggtgc
    19381 ccccggcgga agcggtggcc ggccggccac agctcgacgg cgacgcggcg gacgccgtcc
    19441 gcgcccgcct cgggggcgcc cgggacgagc cgccgcatcc cctcgcacag gttcagcgac
    19501 tcgccgtccg gggccacgtc gcacagccgg acgacgaagt cggtgtgctc ccggttcgag
    19561 cggacccgca ggtccgcggc gaccgggccg atgatctcca ggtcctcctc cagcacggcg
    19621 gaggtgtagg tcagcacgtc ccggcggcgc tccaggcgcc gctggtcggt ggaggggcgg
    19681 gtctcgccga gcagcgtggg cccgccgagg aacggcgtcg ggtgccgggg gtcgtagcgg
    19741 taggagtccg ggtcggactc gggcggcccg gcgggggcga gcgccccgtc cggctggagg
    19801 tgccagcgct cctcggccat ccccgggacg ggccagtcgg ggaactcgcg ccactccgcc
    19861 gcgccggtca cgaacagccg gaccggctgc tcccgcagct gcgacgggtc gtccagcagg
    19921 tgcgcgcgga accacttcac cgcctcgccg accgagccgc gcatcatccg ctggtcggcg
    19981 tggaaccagg ggccgatcgt caggtagggg cggtgcccgg cggcgcgcag cgcggcgtag
    20041 tcccgcagct gccagggcag gaagatgtcg taccagccgc cggtcatgtt gaccggcgcg
    20101 tccacccgcg acaccgtggc gctgaagtcg cggcggtccc agaacggcgt gtcggcgccg
    20161 ttggccagca gttcctggaa gaaccgctgc tgcgcgccgg tcgcgagccg gtccagctcg
    20221 gcgagcgggc ggcccgacag cgcggcccgg cgggcgcggc gcggcgacat gatcccggtc
    20281 gtgatgcccg acagcgagtg cttcatccgg gccgtgaggt cgacccagat cagcgccgac
    20341 tccagcgcga acgccccgcc gacgttcacc gcgtcccgga acgtggacgc cgtgacctgc
    20401 atcgacagcg ccttcagcgc gggccccgcc tcggcggcga cggcccactg cacatagccg
    20461 aggtagctcg ggccgtgcat cgcgaacgcg ccgccgaacc attcctgctc ccgcagccac
    20521 gcgatggtgg cgaggccgtc ctcccgctcg tccagcggct cgaacacccc gcccgacccg
    20581 aacccgccgc gcgcgctctg caccacggcc tggaacccct gcgacgcgaa cgcctgcccg
    20641 cacatcagcc cgaacgggcc gcgccgcccg tagggggagc ggacgagcac caccggcgcc
    20701 cgctccacgt cggcgggcgc gtaccggtcg gccagcaggg tcacgccgtc ggcggcgggg
    20761 acctccaggt cgcgctcgac ccgcacccgg tgggggccgt tccgcagtcc cagcgccgtg
    20821 acccccagcc ggcgcatcat cccgacgctc accacttgat cgatcgtaat cgccggttcc
    20881 gggtaccgcg cgggcggcct cgtcccggga cgcgtcccac ccggtccggt ccttcactac
    20941 gatcgtgggc gaaatccgga tctgcccggc aagtcgacca ttgaggagtg atcagggcgt
    21001 catgggcgac cacctggact ggcggcgggt catcatcgcg gcgatcgtca tggtggccgc
    21061 gctgggggtc gcggtggcgc tgcggatgct caccgggcgg ctgttccgcc gcgccgggga
    21121 cacccgctgg acctgggacg acctggccgc acggctgatc cgcgacctcg cgatgccggt
    21181 cgcggtgctc accggcgcct ggttcgcggc gctggtcctg cacctgccgc gcggcacgct
    21241 ggacgtgacc gcccgggtgc tgaccgccgc gacgatcctc gtggtgtcgc tggcgctggc
    21301 gcggctcatc gccgggtcgg tgacctcgat cgcgatggcg cggcagggcg tggccgccaa
    21361 cgtgacgatc ttcgccaaca tcacccgcgt gatcgtcatc ggcatcggcc tgctggtcat
    21421 gctccagagc ctcggcgtgt cgatcacgcc gctgctcggc gccctcggcg tcggcggcct
    21481 cgcggtcgcc ctcgcgctgc aggacaccct cgccaacctg ttcgcgggcg tgcacgtgct
    21541 cgcgtccaag accatcgagc ccggcgacta catcaagctg agcagcgggc aggaggggta
    21601 cgtcgtcgac atcaactggc gcaacacctc catccgcacg ctgtcggaca acatcgaggt
    21661 catcccgaac cagcggttct ccgacacgat cctcaccaac taccaccggc ccgcgcagga
    21721 catgtcgctg ctgatccagg cgcgcgtccc ctacgaggcc gacctggagc gggtcgagaa
    21781 gctcgtcgtc gaggtcggcg agggcgtgat ggcggacgtg cagggcggcg tgaaggacgc
    21841 ggaggtcctc gtccgcttcc acaccttcgc cgagtcgtcg gtcgacttca ccgtgatcct
    21901 gcgcaccagc gagttcggcg accagttcgc catcaagcac gagttcgtca agcggctgca
    21961 ccggaggttc cgcgaggcgg gcgtcgagac gccctacccg cgccgccgcg tgacgctgga
    22021 cgaggcgtcc ggccccgacg gccgcccggt gtcgccgggc ctgtagcccc gcgggccggg
    22081 gagcgcgtca ggggcgcagg atggggagca ggatctcgtc gaccatcgag gcgagccgct
    22141 cgtcgtccat cgcgccgccc tcggtgaggt ggtcgtacac gaccagcgcc gggccgacgt
    22201 tcgcgacctg gcgggtgacc gcgcccggac ggacctcgcc gcgcgccgcg ccctgctcca
    22261 gcgcctggta gagcatctcc ctgacgggct cggagatgcg cgcgcggatc acgtcgtgca
    22321 tcaggccgtt gctgtcggcg gcctcctcct tcagcacctt gaacgccgcg ccccggcagg
    22381 cgatcagcgt gtcgcgcagg caggtgaggg aggccagcat gtcctcgcgg acgctcccgg
    22441 tcgccggacg cggcggcggg ttcggcagcg cgtgcttgag cgcgtcggtg acgaggtcct
    22501 ccttggactg ccagcgccgg tagagcgcgg ccttgccggt gcgcgccgcg cccgcgatg
//
