Select genomic region:
Overview
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1.13

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP075054.1 (Bacillus velezensis)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | other | 336,834 | 378,252 | High | bacilysin | other:other
Region 2 | RiPP-like,NRP-metallophore,NRPS,terpene-precursor | 894,742 | 960,099 | High | bacillibactin | NRPS:Type I
Region 3 | terpene-precursor | 1,513,454 | 1,534,344 |
Region 4 | transAT-PKS | 1,557,670 | 1,663,848 | High | difficidin | PKS
Region 5 | T3PKS | 1,780,152 | 1,821,252 |
Region 6 | terpene | 1,871,688 | 1,893,571 |
Region 7 | NRPS,betalactone,transAT-PKS | 1,916,140 | 2,053,969 | High | fengycin | NRPS:Type I
Region 8 | transAT-PKS,NRPS,T3PKS | 2,108,472 | 2,218,595 | High | bacillaene | NRPS:Type I+PKS:Type I
Region 9 | transAT-PKS | 2,437,421 | 2,525,637 | High | macrolactin H | PKS
Region 10 | lanthipeptide-class-ii | 2,689,457 | 2,718,346 |
Region 11 | terpene | 2,886,389 | 2,907,129 |
Region 12 | PKS-like | 2,989,144 | 3,030,388 |  |
Region 13 | NRPS | 3,566,060 | 3,631,467 | High | surfactin | NRPS:Type I

NZ_CP075054.1 - Region 1 - other
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 336,834 - 378,252 nt. (total: 41,419 nt) Show pHMM detection rules used
other: (Neocarzinostat or bcpB or frbD or mitE or prnB or CaiA or bacilysin or orf2_PTase)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KH277_RS01765: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

KH277_RS01800: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS01820: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase transferase
KH277_RS01710: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs
  SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

KH277_RS01735: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

KH277_RS01815: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Lyases: dehydratase lyase
KH277_RS01740: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

KH277_RS01745: NAD-dependent epimerase/dehydratase

smcogs
  SMCOG1010: NAD-dependent epimerase/dehydratase

KH277_RS01805: argininosuccinate lyase/adenylosuccinate lyase

smcogs
  SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Translocases: permease
KH277_RS01775: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

KH277_RS01910: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | other | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.98 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.96 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000773.3 |  | 0.54 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000790.3 |  | 0.53 | saccharide | O-antigen | Escherichia coli
BGC0000791.3 |  | 0.53 | saccharide | O-antigen | Cronobacter sakazakii
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis
BGC0001928.2 |  | 0.51 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000888.5 |  | 0.98 | other (other) | bacilysin | Bacillus sp. CS93
BGC0001184.4 |  | 0.96 | other (other) | bacilysin | Bacillus velezensis FZB42
BGC0000898.5 |  | 0.56 | saccharide | desosamine, pikromycin, neomethymycin, narbomycin | Streptomyces venezuelae
BGC0000773.3 |  | 0.54 | saccharide | lipopolysaccharide | Escherichia coli
BGC0000794.5 |  | 0.53 | saccharide | S-layer glycan | Geobacillus stearothermophilus
BGC0000790.3 |  | 0.53 | saccharide | O-antigen | Escherichia coli
BGC0000791.3 |  | 0.53 | saccharide | O-antigen | Cronobacter sakazakii
BGC0001817.5 |  | 0.52 | other (other) | vancosamine | Streptomyces sp. WAC2288
BGC0000899.4 |  | 0.52 | saccharide | desosamine | Streptomyces narbonensis
BGC0001928.2 |  | 0.51 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Location:
Identifier
Identity
Coverage
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.22 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.75 out of 29.38
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.12 out of 23.79
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.63 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.85 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.75 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.45 out of 28.19
Confidence: medium
Additional weak hits (7):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.32 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.66 out of 30.97
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.15 out of 36.54
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 25.29 out of 36.54
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.37 out of 20.01
Confidence: weak
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.89 out of 32.93
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
IolR | Regulator of the inositol catabolism
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 2 - NRP-metallophore,NRPS,RiPP-like,terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 894,742 - 960,099 nt. (total: 65,358 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))
NRP-metallophore: (VibH_like or Cy_tandem or (cds(Condensation and AMP-binding) and ((IBH_Asp and not SBH_Asp) or IBH_His or TBH_Asp or CyanoBH_Asp1 or CyanoBH_Asp2 or IPL or SalSyn or (EntA and EntC) or (GrbD and GrbE) or (FbnL and FbnM) or PvdO or PvdP or (Orn_monoox and not (KtzT or MetRS-like)) or Lys_monoox or VbsL)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
KH277_RS04605: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS04655: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

KH277_RS04660: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

KH277_RS04710: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS04785: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Hydrolases: esterase hydrolase
KH277_RS04725: isochorismatase

smcogs
  SMCOG1027: isochorismatase

KH277_RS04820: isochorismatase

smcogs
  SMCOG1027: isochorismatase

KH277_RS04865: thioesterase superfamily protein

smcogs
  SMCOG1144: thioesterase superfamily protein

Isomerases: isomerase
KH277_RS04715: isochorismate synthase

smcogs
  SMCOG1018: isochorismate synthase

Ligases: ligase synthetase
KH277_RS04720: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS04730: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KH277_RS04845: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | NRP-metallophore | NRPS | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0000616.4 |  |  |  |  | 2.39 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  |  |  |  | 1.51 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  |  |  |  | 1.07 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  |  |  |  | 1.04 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  |  |  |  | 0.88 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  |  |  |  | 0.86 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  |  |  |  | 0.77 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  |  |  |  | 0.76 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  |  |  |  | 0.75 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  |  |  |  | 0.74 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000616.4 |  | 0.95 | ribosomal | amylocyclicin | Bacillus velezensis FZB42
BGC0001185.5 |  | 0.91 | NRPS | bacillibactin | Bacillus velezensis FZB42
BGC0000309.5 |  | 0.81 | NRPS | bacillibactin | Bacillus subtilis subsp. subtilis str. 168
BGC0000401.5 |  | 0.80 | NRPS | paenibactin | Paenibacillus elgii B69
BGC0002075.3 |  | 0.75 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0000343.5 |  | 0.74 | NRPS | enterobactin | Pseudomonas sp. J465
BGC0001132.4 |  | 0.71 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.70 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001128.4 |  | 0.70 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4 |  | 0.70 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP
diterpene precursor |  | GGPP | C20 | acyclic | PP
sesterterpene precursor |  | GFPP | C25 | acyclic | PP
triterpene precursor |  | HPP | C30 | acyclic | PP

Genes with terpene domains:
KH277_RS04845: PT_FPPS_like
Domain 1 (24 - 286): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: unknown

Reactions:
  IPP, DMAPP → FPP
  IPP, DMAPP → GGPP
  IPP, DMAPP → GFPP
  IPP, DMAPP → HPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.15 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.61 out of 29.38
Confidence: strong
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 29.38 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.40 out of 19.26
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.23 out of 21.55
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.52 out of 27.78
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 24.91 out of 29.38
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 26.49 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.87 out of 27.78
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.61 out of 20.97
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.57 out of 27.55
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.18 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.98 out of 28.19
Confidence: medium
Additional weak hits (18):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.85 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.90 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.15 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.44 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.58 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.31 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.52 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.12 out of 29.38
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.61 out of 32.74
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.80 out of 28.14
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 20.84 out of 29.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.88 out of 29.51
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.88 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.99 out of 33.14
Confidence: weak
OsdR
Description: Development and stress management regulator
Species: Streptomyces coelicolor
Score: 20.81 out of 30.12
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
Terpene
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 2, location 894741 - 960099:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 894797 - 946533:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Gly - Thr)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KH277_RS04720: diOH-Bz
Search NORINE for peptide: strict or relaxed
AMP-binding (31..435): diOH-Bz
nrpys: diOH-Bz

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Small clusters prediction:
    Hydroxy-benzoic acid derivates (diOH-Bz, Sal)
  Single AA prediction:
    dhb (diOH-Bz)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SLSLYPLSSPGGALQVGGAQQVFGMAEGLVNYTR
  Nearest Stachelhaus code(s):
    diOH-Bz PLPAQGVVNK (97% 8Å match)
    diOH-Bz or Sal PLPAQGVVNK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS04730: Gly - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (456..855): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDISGLELQALVGGETNLYGPTETTIWSAA
  Nearest Stachelhaus code(s):
    Gly DILQLGLIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1513..1929): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSTHFDFSVWEGNQIFGGEVNMYGITETTVHVSY
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
GFPP | Geranylfarnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
HPP | Hexaprenyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,513,454 - 1,534,344 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: carboxylase
KH277_RS07875: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Ligases: synthase synthetase
KH277_RS07905: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

KH277_RS07910: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002283.2 |  | 0.49 | terpene | sodorifen | Serratia plymuthica
BGC0001361.3 |  | 0.49 | terpene | sodorifen | Serratia plymuthica 4Rx13
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.39 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0002284.3 |  | 0.38 | other (other) | corynecin III, corynecin I, corynecin II | Rhodococcus sp. H-CA8f
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0000638.3 |  | 0.37 | terpene | carotenoid | Pantoea ananatis
BGC0000640.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC404

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
KH277_RS07905: PT_FPPS_like
Domain 1 (33 - 296): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.14 out of 27.78
Confidence: medium
Additional weak hits (1):
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.83 out of 29.25
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator

NZ_CP075054.1 - Region 4 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,557,670 - 1,663,848 nt. (total: 106,179 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase oxygenase
KH277_RS08135: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

KH277_RS08160: NADH:flavin oxidoreductase/NADH oxidase

smcogs
  SMCOG1217: NADH:flavin oxidoreductase/NADH oxidase

KH277_RS08200: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS08205: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS08220: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS08225: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS08235: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

KH277_RS08240: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

KH277_RS08265: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS08345: aldo/keto reductase family oxidoreductase

smcogs
  SMCOG1039: aldo/keto reductase family oxidoreductase

Transferases: acylase transferase
KH277_RS08110: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

KH277_RS08180: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: deacetylase hydrolase
KH277_RS08115: acetylornithine deacetylase

smcogs
  SMCOG1247: acetylornithine deacetylase

KH277_RS08260: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Lyases: hydratase
KH277_RS08250: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
KH277_RS08195: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS08215: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KH277_RS08230: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KH277_RS08245: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.91 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001383.3 |  | 0.58 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0002056.3 |  | 0.58 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001012.3 |  | 0.55 | NRPS, PKS | meridamycin | Streptomyces violaceusniger
BGC0001795.3 |  | 0.54 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.54 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000176.5 |  | 0.91 | PKS | difficidin | Bacillus velezensis FZB42
BGC0001164.3 |  | 0.64 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001160.5 |  | 0.63 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0000174.5 |  | 0.60 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001383.3 |  | 0.58 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0002056.3 |  | 0.58 | NRPS, PKS | peloruside A | sponge metagenome
BGC0001012.3 |  | 0.55 | NRPS, PKS | meridamycin | Streptomyces violaceusniger
BGC0001795.3 |  | 0.54 | PKS | swinholide A | Nostoc sp. UHCC 0450
BGC0000067.5 |  | 0.54 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus
BGC0000205.3 |  | 0.52 | PKS | bryostatin | Candidatus Endobugula sertula

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.92 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.33 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.19 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.96 out of 24.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.22 out of 18.57
Confidence: strong
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 20.30 out of 25.31
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.89 out of 27.78
Confidence: medium
Additional weak hits (8):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.08 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.61 out of 30.25
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 21.46 out of 30.97
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.34 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 22.13 out of 30.97
Confidence: weak
CopR
Description: Copper-responsive regulator
Species: Lactococcus lactis subsp. lactis Il1403
Score: 26.71 out of 30.97
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 7, location 1557669 - 1663848:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (Me-ccmal - ccmal - mal) + (ohmal - mal) + (mal) + (ccmal - ccmal - ohmal - ccmal) + (ohmal - mal) + (Me-ccmal) + (mal)
Non-colinear ordering:
  KH277_RS08205 + KH277_RS08210 + KH277_RS08215 + KH277_RS08220 + KH277_RS08225 + KH277_RS08230 + KH277_RS08235

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KH277_RS08180: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 83.3%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 87.0
  inactive: 30.6
  Methoxymalonyl-CoA: 29.3
  Methylmalonyl-CoA: 21.3
  Propionyl-CoA: 15.8
  2-Methylbutyryl-CoA: 14.9
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0

KH277_RS08195: X
AMP-binding (15..363): X
nrpys: (unknown)

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    ALLLHIGGINTAPATYGTEKQTYGLTELGIFSTK
  Nearest Stachelhaus code(s):
    2,3-dohHda IGNPTGTIMK (74% 8Å match)
  Stachelhaus code match:
    90% (moderate)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
ToxT | Regulator of MSHA biosynthesis

NZ_CP075054.1 - Region 5 - T3PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,780,152 - 1,821,252 nt. (total: 41,101 nt) Show pHMM detection rules used
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Transferases: acetyltransferase methyltransferase
KH277_RS09145: GCN5-related N-acetyltransferase

smcogs
  SMCOG1111: GCN5-related N-acetyltransferase

KH277_RS09155: isoprenylcysteine carboxyl methyltransferase

smcogs
  SMCOG1150: isoprenylcysteine carboxyl methyltransferase

Hydrolases: hydrolase
KH277_RS09125: isochorismatase

smcogs
  SMCOG1027: isochorismatase

Ligases: synthase
KH277_RS09150: chalcone and stilbene synthase domain protein

smcogs
  SMCOG1024: chalcone and stilbene synthase domain protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002332.2 |  | 0.44 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0002254.3 |  | 0.33 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001964.2 |  | 0.33 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001663.3 |  | 0.32 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000282.3 |  | 0.55 | PKS | 2-methoxy-5-methyl-6-(13-methyltetradecyl)-1,4-benzoquinone, 2-methoxy-5-methyl-6-(13-methyltetradecyl)phenol | Streptomyces griseus subsp. griseus NBRC 13350
BGC0001831.3 |  | 0.54 | PKS | alkylpyrone-407, alkylpyrone-393 | Myxococcus xanthus DK 1622
BGC0002332.2 |  | 0.44 | PKS | 4-hydroxy-6-pentadecylpyran-2-one, 4-hydroxy-6-(2-oxoheptadecyl)pyran-2-one, Adipostatin A | Candidatus Entotheonella sp.
BGC0001475.4 |  | 0.43 | terpene | aspterric acid | Aspergillus terreus NIH2624
BGC0001289.5 |  | 0.35 | ribosomal | penisin | Paenibacillus ehimensis
BGC0001647.3 |  | 0.34 | PKS | lagunapyrone A, lagunapyrone B, lagunapyrone C | Streptomyces sp. MP131-18
BGC0002254.3 |  | 0.33 | PKS | notoamide F, (+)-semivioxanthin, waikikiamide B, waikikiamide C, notoamide A, waikikiamide A | Aspergillus sp. FM242
BGC0001964.2 |  | 0.33 | PKS | alkylpyrone-407, alkylpyrone-393 | Cystobacterineae bacterium
BGC0001663.3 |  | 0.32 | PKS | merocyclophane C, merocyclophane D | Nostoc sp. UIC 10110
BGC0001928.2 |  | 0.32 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 27.26 out of 29.38
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.98 out of 20.97
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.80 out of 26.33
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.64 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.39 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.67 out of 21.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.51 out of 26.06
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.84 out of 29.38
Confidence: medium
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.15 out of 18.46
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.73 out of 28.19
Confidence: strong
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 25.16 out of 28.19
Confidence: strong
LexA variant 3
Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.10 out of 32.93
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
Additional weak hits (11):
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.28 out of 26.06
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.18 out of 25.75
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.22 out of 31.73
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 26.01 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.58 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.23 out of 29.38
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 23.07 out of 30.22
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.01 out of 24.78
Confidence: weak
LexA variant 1
Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.96 out of 29.65
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.45 out of 29.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.42 out of 28.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
LexA variant 3 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 6 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,871,688 - 1,893,571 nt. (total: 21,884 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KH277_RS09645: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Hydrolases: hydrolase
KH277_RS09620: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002173.2 |  | 0.47 | saccharide, terpene | fumihopaside A, compound 3, 21-β-H-hopane-3beta, 22-diol | Aspergillus fumigatus A1163
BGC0001535.3 |  | 0.43 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000313.4 |  | 0.36 | NRPS | beauvericin | Beauveria bassiana
BGC0002255.3 |  | 0.33 | PKS | lijiquinone | Ascomycota sp. F53
BGC0000663.5 |  | 0.30 | terpene | hopene | Streptomyces coelicolor A3(2)
BGC0000686.3 |  | 0.30 | terpene | helvolic acid | Aspergillus fumigatus Af293
BGC0001575.4 |  | 0.29 | NRPS | PZN5, PZN6, PZN7, PZN9, PZN10, PZN11 | Ruminococcus sp. 5_1_39BFAA
BGC0001338.4 |  | 0.28 | PKS | citrinin | Monascus ruber
BGC0000154.4 |  | 0.28 | PKS | stipitatic acid | Talaromyces stipitatus ATCC 10500
BGC0001739.3 |  | 0.28 | other (other) | phosphonoacetic Acid | Streptomyces sp. NRRL F-525

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | hopanoid |  | C30 | hopanoid skeleton | unknown
triterpene | polypodane |  | C30 | polypodane skeleton | unknown

Genes with terpene domains:
KH277_RS09640: T2TS
Domain 1 (5 - 624): Type 2 terpene synthase
Subtype: Squalene substrate

Reactions:
  squalene → hopanoid
  squalene → polypodane

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.53 out of 26.06
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.26 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.86 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.70 out of 28.19
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16
Confidence: strong
Additional weak hits (7):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.63 out of 25.75
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.14 out of 39.62
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.10 out of 29.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.90 out of 26.06
Confidence: weak
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 18.62 out of 21.55
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.62 out of 30.25
Confidence: weak
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 19.98 out of 24.78
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.
No acronyms to display
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 7 - NRPS,betalactone,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,916,140 - 2,053,969 nt. (total: 137,830 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
betalactone: (HMGL-like and AMP-binding)
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
KH277_RS09860: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs
  SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

KH277_RS09960: acyl-CoA dehydrogenase

smcogs
  SMCOG1006: acyl-CoA dehydrogenase

KH277_RS10035: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

KH277_RS10055: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS10140: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS10155: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: acylase aminotransferase carboxylase kinase transferase
KH277_RS09970: acetyl-CoA carboxylase biotin carboxylase

smcogs
  SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

KH277_RS09990: acetyl-CoA carboxylase, carboxyl transferase,

smcogs
  SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

KH277_RS10000: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs
  SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

KH277_RS10015: aminotransferase class-III

smcogs
  SMCOG1013: aminotransferase class-III

KH277_RS10060: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

KH277_RS10160: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: peptidase
KH277_RS09885: gamma-glutamyltranspeptidase

smcogs
  SMCOG1274: gamma-glutamyltranspeptidase

Lyases: hydratase
KH277_RS09985: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
KH277_RS09925: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS09930: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS09935: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS09940: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS09945: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KH277_RS09965: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS09980: 2-isopropylmalate synthase

smcogs
  SMCOG1271: 2-isopropylmalate synthase

KH277_RS10020: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

KH277_RS10065: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KH277_RS10070: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS10075: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | betalactone | transAT-PKS | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0002135.2 |  |  |  |  | 1.59 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001833.4 |  |  |  |  | 1.59 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001098.5 |  |  |  |  | 1.53 | NRPS, PKS | iturin | Bacillus subtilis
BGC0001128.4 |  |  |  |  | 1.51 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  |  | 1.50 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001095.5 |  |  |  |  | 1.50 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001132.4 |  |  |  |  | 1.49 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001825.4 |  |  |  |  | 1.49 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001090.5 |  |  |  |  | 1.48 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001758.4 |  |  |  |  | 1.47 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001095.5 |  | 0.92 | NRPS | fengycin | Bacillus velezensis FZB42
BGC0001090.5 |  | 0.87 | NRPS, PKS | bacillomycin D | Bacillus velezensis FZB42
BGC0001098.5 |  | 0.87 | NRPS, PKS | iturin | Bacillus subtilis
BGC0000407.5 |  | 0.81 | NRPS | plipastatin | Bacillus subtilis subsp. subtilis
BGC0000402.4 |  | 0.80 | NRPS | paenilarvin A, paenilarvin B, paenilarvin C | Paenibacillus larvae subsp. larvae DSM 25430
BGC0001103.5 |  | 0.79 | NRPS, PKS | mycosubtilin | Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001758.4 |  | 0.75 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.93 out of 29.25
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.10 out of 27.55
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 20.32 out of 20.97
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 18.15 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 17.48 out of 18.57
Confidence: strong
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 21.93 out of 26.33
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.71 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 22.29 out of 27.55
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.08 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
Additional weak hits (10):
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.41 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
VqsM
Description: Regulator of quorum-sensing signalling systems
Species: Pseudomonas aeruginosa PAO1
Score: 17.44 out of 20.47
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.74 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.46 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.52 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.68 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 10, location 1916139 - 2053969:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile) + (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 11, location 1916139 - 1993809:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - D-Orn) + (Tyr - D-Thr) + (Glu - D-X) + (Pro - Gln - D-Tyr) + (Ile)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 12, location 1976723 - 2053969:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - mal - Asn - D-Tyr) + (D-Asn - Gln - Pro - D-Asn) + (Ser)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KH277_RS09925: Glu - Orn
Search NORINE for peptide: strict or relaxed
AMP-binding (463..868): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1905): Orn
nrpys: Orn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Long positively charged side chain (Orn, Lys, Arg)
  Small clusters prediction:
    Orn and hydroxy-Orn specific (Orn, OH-Orn)
  Single AA prediction:
    orn (Orn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    AAWAFDVFSGDRESVLGSDINSYGVTEATIDSSY
  Nearest Stachelhaus code(s):
    Orn DVGEVGSIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS09930: Tyr - Thr
Search NORINE for peptide: strict or relaxed
AMP-binding (474..867): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGSLTSTLITFAGELNEYGPTENSVATTI
  Nearest Stachelhaus code(s):
    Tyr DGTLTAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1509..1905): Thr
nrpys: Thr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    thr (Thr)
  Single AA prediction:
    thr (Thr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHKHFDFSVWEGNQIFGGEVNMYGITETTVHVTC
  Nearest Stachelhaus code(s):
    Thr DFWNIGMVHK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS09935: Glu - X
Search NORINE for peptide: strict or relaxed
AMP-binding (468..873): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FGMSFDASIWQWHFFAGGEIHGYGPTEATVDAAF
  Nearest Stachelhaus code(s):
    Glu DAWHFGGVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1505..1898): X
nrpys: Ala, Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSSFDVTTFEGWLIIGGEWNGYGPTENTTFSTC
  Nearest Stachelhaus code(s):
    Ala or Val DVFWIGGTFK (97% 8Å match)
    Val DVFWIGGTFK (94% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS09940: Pro - Gln - Tyr
Search NORINE for peptide: strict or relaxed
AMP-binding (469..866): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LDQAFDVCYQESFFITAGEHNHYGPSETHVVSTY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1500..1901): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    glu (Glu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSLTFDASIWEWHFFAGGETNSYGPTETTVEAAY
  Nearest Stachelhaus code(s):
    Gln DAWHFGSVEK (97% 8Å match)
    Glu DAWHFGSVEK (91% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2532..2924): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TWRFFDGFVTSTIITLAGEANEYGPTENSVATTA
  Nearest Stachelhaus code(s):
    Tyr DGTITAEVAK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS09945: Ile
Search NORINE for peptide: strict or relaxed
AMP-binding (473..866): Ile
nrpys: Ile

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    ile (Ile)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LNSGFDAVTFEGFLYVGGEYNIYGPTENTTFSTF
  Nearest Stachelhaus code(s):
    Ile DAFFYGITFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS09965: X
AMP-binding (12..445): X
nrpys: Asp, Asn, Glu, Gln, Aad

SVM prediction details:
  Predicted physicochemical class:
    N/A
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    NNIVF-GCVLGAHGIMAGSTIAYGQTEASPVITQ
  Nearest Stachelhaus code(s):
    Z-ahmohOrn FGLHIASTCK (56% 8Å match)
    Ile DGLFIGIPVK (32% 8Å match)
  Stachelhaus code match:
    60% (weak)

KH277_RS10060: mal
PKS_AT (6..290): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 62.5%
  inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 71.1
  inactive: 30.1
  Methoxymalonyl-CoA: 18.6
  Propionyl-CoA: 12.1
  Methylmalonyl-CoA: 10.8
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

KH277_RS10065: fatty_acid - Asn
Search NORINE for peptide: strict or relaxed
CAL_domain (36..478): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 621.6
  NH2: 17.4
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (2956..3351): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGEFNEYGPTEAVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS10070: Tyr - Asn - Gln - Pro
Search NORINE for peptide: strict or relaxed
AMP-binding (268..662): Tyr
nrpys: Tyr

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
  Large clusters prediction:
    Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
  Small clusters prediction:
    Polar aromatic ring (Tyr, bOH-Tyr)
  Single AA prediction:
    tyr (Tyr)

Stachelhaus prediction details:
  Stachelhaus sequence:
    SWKYFDAFILNGSTVVGGENNEYGPTENSVVSTF
  Nearest Stachelhaus code(s):
    Tyr DALSVGEVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1779..2174): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTVTSTKLIVGGECNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (3288..3693): Gln
nrpys: Gln

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LGLAFDASVQQADGLIGGETNVYGPTETCVDASL
  Nearest Stachelhaus code(s):
    Gln DAQDLGVVDK (100% 8Å match)
    Ile DAQDLGVVDK (74% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (4337..4733): Pro
nrpys: Pro

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Cyclic aliphatic chain (polar NH2 group) (Pro, Hpr)
  Small clusters prediction:
    pro (Pro)
  Single AA prediction:
    pro (Pro)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LYEAFDVCYQESFLIAAGEHNHYGPSETHVVTMY
  Nearest Stachelhaus code(s):
    Pro DVQFIAHVVK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS10075: Asn - Ser
Search NORINE for peptide: strict or relaxed
AMP-binding (268..663): Asn
nrpys: Asn

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asn (Asn)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWASFDLTITSTKLIVGGDFNEYGPTETVVGCMI
  Nearest Stachelhaus code(s):
    Asn DLTKIGEVGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1778..2185): Ser
nrpys: Ser

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Aliphatic chain or phenyl group with -OH (Ser, Thr, Dhpg, Hpg)
  Small clusters prediction:
    ser (Ser)
  Single AA prediction:
    ser (Ser)

Stachelhaus prediction details:
  Stachelhaus sequence:
    RWMTFDVSVWEWHFFASGEINLYGPTEATIDVSY
  Nearest Stachelhaus code(s):
    Ser DVWHFSLIDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
GnfM | Regulator of nitrogen-fixation genes
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence
SypG | Regulator of biofilm formation and host colonization
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 8 - NRPS,T3PKS,transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,108,472 - 2,218,595 nt. (total: 110,124 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
T3PKS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxygenase
KH277_RS10570: cytochrome P450

smcogs
  SMCOG1007: cytochrome P450

KH277_RS10590: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS10675: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

Transferases: acylase
KH277_RS10620: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

KH277_RS10625: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

KH277_RS10630: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Hydrolases: hydrolase protease
KH277_RS10550: alkaline serine protease, subtilase family

smcogs
  SMCOG1075: alkaline serine protease, subtilase family

KH277_RS10635: metallo-beta-lactamase family protein

smcogs
  SMCOG1170: metallo-beta-lactamase family protein

KH277_RS10695: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

Lyases: hydratase
KH277_RS10600: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

KH277_RS10605: enoyl-CoA hydratase

smcogs
  SMCOG1023: enoyl-CoA hydratase

Ligases: ligase synthase
KH277_RS10575: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KH277_RS10580: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KH277_RS10585: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

KH277_RS10595: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KH277_RS10610: hydroxymethylglutaryl-CoA synthase

smcogs
  SMCOG1043: hydroxymethylglutaryl-CoA synthase

KH277_RS10670: 8-amino-7-oxononanoate synthase

smcogs
  SMCOG1109: 8-amino-7-oxononanoate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | NRPS | NRPS | T3PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | --- | --- | --- | ---
BGC0001089.5 |  |  |  |  | 1.63 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0001160.5 |  |  |  |  | 1.03 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0002135.2 |  |  |  |  | 1.03 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  |  |  |  | 0.97 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  |  |  |  | 0.97 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001833.4 |  |  |  |  | 0.96 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  |  |  |  | 0.96 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  |  |  |  | 0.94 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  |  |  |  | 0.93 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001758.4 |  |  |  |  | 0.91 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001089.5 |  | 0.90 | NRPS, PKS | bacillaene | Bacillus velezensis FZB42
BGC0002135.2 |  | 0.70 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0001132.4 |  | 0.69 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001833.4 |  | 0.69 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0001825.4 |  | 0.69 | NRPS | xenematide | Xenorhabdus nematophila AN6/1
BGC0001128.4 |  | 0.68 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3 |  | 0.67 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001135.5 |  | 0.67 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.66 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001641.4 |  | 0.65 | NRPS | kolossin | Photorhabdus laumondii subsp. laumondii TTO1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.29 out of 27.78
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.47 out of 21.55
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.04 out of 18.57
Confidence: strong
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 23.59 out of 30.25
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 24.10 out of 24.78
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.60 out of 26.06
Confidence: medium
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.14 out of 18.16
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.14 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.62 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.78 out of 20.97
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.46 out of 27.78
Confidence: medium
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 20.30 out of 24.78
Confidence: medium
Additional weak hits (20):
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.08 out of 39.62
Confidence: weak
LuxO
Description: Repressor of luminescence
Species: Vibrio campbellii ATCC BAA-1116
Score: 21.58 out of 26.12
Confidence: weak
RicR
Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.62 out of 32.93
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.53 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 20.38 out of 28.14
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.54 out of 36.54
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.39 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.52 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.04 out of 30.25
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.67 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.06 out of 26.06
Confidence: weak
MntR
Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.07 out of 39.62
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.45 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.08 out of 26.06
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.68 out of 31.73
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.22 out of 28.14
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 24.16 out of 32.74
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.96 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.51 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.45 out of 26.06
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 13, location 2108471 - 2218595:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (fatty_acid - Gly - ccmal - ohmal - mal) + (ccmal - mal - ohmal - mal) + (Me-ccmal - ohmal) + (Ala - ccmal - ccmal - Me-ccmal) + (mal - mal)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KH277_RS10580: Ala
Search NORINE for peptide: strict or relaxed
AMP-binding (492..896): Ala
nrpys: Ala

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    N/A
  Small clusters prediction:
    N/A
  Single AA prediction:
    N/A

Stachelhaus prediction details:
  Stachelhaus sequence:
    TFLTFDVSISEGNFMVAGEENIYGPTETSIYAAY
  Nearest Stachelhaus code(s):
    Ala DVSNMAIIYK (88% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS10595: fatty_acid - Gly
Search NORINE for peptide: strict or relaxed
CAL_domain (74..476): fatty_acid
minowa: fatty_acid

Prediction, score:
  fatty_acid: 26.7
  NH2: 9.4
  shikimic_acid: 0.0
  Acetyl-CoA: 0.0
  AHBA: 0.0

AMP-binding (1145..1540): Gly
nrpys: Gly

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
  Single AA prediction:
    gly (Gly)

Stachelhaus prediction details:
  Stachelhaus sequence:
    FSMTFDIAALELQALCGGEWNMFGPTETTIWSAV
  Nearest Stachelhaus code(s):
    Gly DILQLGMIWK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS10620: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 66.7%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 86.1
  inactive: 31.3
  Methoxymalonyl-CoA: 24.6
  Methylmalonyl-CoA: 11.2
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

KH277_RS10625: mal
PKS_AT (7..293): mal
ATSignature: (unknown)
No matches above 50%
minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 33.9
  inactive: 25.6
  Methoxymalonyl-CoA: 17.8
  Benzoyl-CoA: 11.5
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Propionyl-CoA: 0.0
  Methylmalonyl-CoA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

KH277_RS10630: mal
PKS_AT (4..285): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 87.5%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 99.9
  inactive: 47.0
  Methoxymalonyl-CoA: 40.6
  Methylmalonyl-CoA: 25.5
  Propionyl-CoA: 23.9
  trans-1,2-CPDA: 0.0
  fatty_acid: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
ColR | Phenol-responsive regulator
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis

NZ_CP075054.1 - Region 9 - transAT-PKS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,437,421 - 2,525,637 nt. (total: 88,217 nt) Show pHMM detection rules used
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase
KH277_RS11855: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

KH277_RS11885: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS11895: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS11900: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

KH277_RS11910: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acylase kinase
KH277_RS11915: malonyl CoA-acyl carrier protein transacylase

smcogs
  SMCOG1021: malonyl CoA-acyl carrier protein transacylase

KH277_RS12015: PfkB domain protein

smcogs
  SMCOG1276: PfkB domain protein

Hydrolases: deacetylase deformylase hydrolase phosphatase
KH277_RS11815: inositol monophosphatase

smcogs
  SMCOG1207: inositol monophosphatase

KH277_RS11845: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

KH277_RS11875: beta-lactamase

smcogs
  SMCOG1053: beta-lactamase

KH277_RS11880: alpha/beta hydrolase fold protein

smcogs
  SMCOG1036: alpha/beta hydrolase fold protein

KH277_RS11930: peptide deformylase

smcogs
  SMCOG1275: peptide deformylase

KH277_RS11935: hydrolase

smcogs
  SMCOG1179: hydrolase

Ligases: synthase
KH277_RS11865: 1-deoxy-D-xylulose-5-phosphate synthase

smcogs
  SMCOG1110: 1-deoxy-D-xylulose-5-phosphate synthase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | transAT-PKS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.83 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.82 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000174.5 |  | 0.64 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001160.5 |  | 0.62 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001254.3 |  | 0.62 | PKS | ACT-Toxin II | Alternaria alternata
BGC0001164.3 |  | 0.62 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001535.3 |  | 0.54 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001069.5 |  | 0.53 | NRPS, PKS | chivosazol | Sorangium cellulosum
BGC0000067.5 |  | 0.52 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000181.5 |  | 0.83 | PKS | macrolactin H | Bacillus velezensis FZB42
BGC0001383.3 |  | 0.82 | PKS | macrolactin H, macrolactin B, macrolactin 1c, macrolactin E | Jeotgalibacillus marinus
BGC0001534.3 |  | 0.70 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0000174.5 |  | 0.64 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0001160.5 |  | 0.62 | PKS | 1-nonadecene, (14Z)-1,14-nonadecadiene | Synechococcus sp. PCC 7002
BGC0001254.3 |  | 0.62 | PKS | ACT-Toxin II | Alternaria alternata
BGC0001164.3 |  | 0.62 | PKS | 1-heptadecene | Cyanothece sp. PCC 7822
BGC0001535.3 |  | 0.54 | other (other) | branched-chain fatty acids | Streptomyces filamentosus
BGC0001069.5 |  | 0.53 | NRPS, PKS | chivosazol | Sorangium cellulosum
BGC0000067.5 |  | 0.52 | PKS | geldanamycin | Streptomyces hygroscopicus subsp. duamyceticus

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.63 out of 27.78
Confidence: strong
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.94 out of 21.55
Confidence: medium
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.55 out of 19.26
Confidence: medium
Additional weak hits (7):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 23.20 out of 31.73
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.35 out of 26.33
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.65 out of 29.25
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.27 out of 30.22
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.56 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.30 out of 26.06
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.99 out of 33.14
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 14, location 2437420 - 2525637:
Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:
  (ohmal - ccmal) + (ccmal - mal) + (ccmal - mal) + (ohmal) + (ohmal - mal)
Non-colinear ordering:
  KH277_RS11910 + KH277_RS11900 + KH277_RS11895 + KH277_RS11890 + KH277_RS11885 + KH277_RS11880

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KH277_RS11915: mal
PKS_AT (4..282): mal
ATSignature: Malonyl-CoA

Top 3 matches:
  Malonyl-CoA: 75.0%
  inactive: 62.5%

minowa: Malonyl-CoA

Prediction, score:
  Malonyl-CoA: 92.6
  inactive: 32.0
  Methoxymalonyl-CoA: 28.0
  Methylmalonyl-CoA: 20.8
  Propionyl-CoA: 17.4
  fatty_acid: 13.9
  trans-1,2-CPDA: 0.0
  Isobutyryl-CoA: 0.0
  Ethylmalonyl-CoA: 0.0
  CHC-CoA: 0.0
  Benzoyl-CoA: 0.0
  Acetyl-CoA: 0.0
  3-Methylbutyryl-CoA: 0.0
  2-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ArcA | Repressor of carbon oxidation
CRP | Cyclic AMP receptor protein
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria

NZ_CP075054.1 - Region 10 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,689,457 - 2,718,346 nt. (total: 28,890 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
KH277_RS12960: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

KH277_RS12980: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000554.4 |  | 0.56 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000516.4 |  | 0.53 | ribosomal | geobacillin II | Geobacillus thermodenitrificans
BGC0000626.3 |  | 0.52 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0001555.4 |  | 0.51 | ribosomal | colicin V | Escherichia coli chi7122
BGC0001210.5 |  | 0.51 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000590.5 |  | 0.50 | ribosomal | microcin N | Escherichia coli
BGC0001311.5 |  | 0.50 | ribosomal | flavecins | Ruminococcus flavefaciens FD-1
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000527.5 |  | 0.49 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for KH277_RS12960

KH277_RS12895
Leader:
MCKLCGPKKVIVTETGFGA
Core:
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
Core with dehydrations:
V F H P Cys P N Cys K Dhb G Dhb D L Dhb P V I K R L E R M V Q D A K A R L D A R V

#### antiSMASH-DB 4.0 matches for KH277_RS12895

100.0%
NC_023073.1 and 25 others:
NZ_CP010556.1 Lanthipeptides: SB45_RS19805_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19795_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20400_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22075_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS21000_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21480_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19740_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19585_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20470_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21110_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20035_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16480_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06705_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18975_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06485_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16830_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06200_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12895_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06150_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06335_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11720_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS03045_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19745_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19365_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18850_lanthipeptide
Lanthipeptides: U722_RS20005_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
97.2%
NZ_CP025341.1:
Lanthipeptides: CXR48_RS19565_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D L R V
36
89.7%
NZ_CP023075.1 and 8 others:
NZ_CP035393.1 Lanthipeptides: ES966_RS21105_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20970_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19665_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17705_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03370_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01895_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00520_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122700_lanthipeptide
Lanthipeptides: CK238_RS20695_lanthipeptide
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K A R L D A R V
36
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K R L D A R V
1
V F H P C P N C K T G T D L T P V I K R L E R M V Q D A K V R L D A R V
36
with 2 more sequence matches
22.2%
NC_015600.1 and 17 others:
NZ_AP020310.1 Lanthipeptides: SAGCMC97051_RS07300_lanthipeptide NZ_ATVP01000001.1 Lanthipeptides: G574_RS11150_lanthipeptide NZ_BCFB01000042.1 Lanthipeptides: GOZ36_RS07980_lanthipeptide NZ_CP024974.1 Lanthipeptides: CVO91_RS06555_lanthipeptide NZ_CP068708.1 Lanthipeptides: JM964_RS04040_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_CP116958.1 Lanthipeptides: M0P28_RS07755_lanthipeptide NZ_FIKS01000005.1 Lanthipeptides: A0525_RS10015_lanthipeptide NZ_GL636070.1 Lanthipeptides: HMPREF9171_RS106200_lanthipeptide NZ_JADPLU010000018.1 Lanthipeptides: I4V82_RS09545_lanthipeptide NZ_JAIMDQ010000006.1 Lanthipeptides: K6V44_RS04045_lanthipeptide NZ_JAKVIE010000017.1 Lanthipeptides: MK857_RS08340_lanthipeptide NZ_JAMDIB010000004.1 Lanthipeptides: M5P35_RS04030_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_JAQDQV010000001.1 Lanthipeptides: PGO74_RS00635_lanthipeptide NZ_LR594050.1 Lanthipeptides: FGL20_RS03485_lanthipeptide NZ_SSXN01000004.1 Lanthipeptides: FAJ36_RS04715_lanthipeptide
Lanthipeptides: SGPB_RS10680_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G I L M T C A I K
22
22.2%
NZ_CP059471.1 and 3 others:
NZ_FNZW01000001.1 Lanthipeptides: BMZ61_RS02110_lanthipeptide NZ_FOYC01000001.1 Lanthipeptides: BMZ88_RS03370_lanthipeptide NZ_KE384124.1 Lanthipeptides: G597_RS0106700_lanthipeptide
Lanthipeptides: H1R75_RS06635_lanthipeptide
6
P N C K T G T D L T P V I K
19
P C K T G +T I K
9
P G C K T G A L M T C P I K
22

#### MIBiG 4.0 matches for KH277_RS12895

13.9%
BGC0000535.4 (ADJ56352.1):
Lanthipeptide: nisin A
6
P N C K T G
11
P C K T G
9
P G C K T G
14
KH277_RS12965
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for KH277_RS12965

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for KH277_RS12965

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
KH277_RS12970
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for KH277_RS12970

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for KH277_RS12970

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
KH277_RS12985
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for KH277_RS12985

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for KH277_RS12985

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
allorf_2689692_2689793
Leader:
MSYVCHLEVNRRSQKAARLEAA
Core:
F Y Y R Q S C R R W R
Core with dehydrations:
F Y Y R Q Dha Cys R R W R

#### antiSMASH-DB 4.0 matches for allorf_2689692_2689793

100.0%
NC_023073.1 and 25 others:
NZ_CP010556.1 Lanthipeptides: allorf_1184096_1184197_lanthipeptide NZ_CP016371.1 Lanthipeptides: allorf_1217185_1217286_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1280116_1280217_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1237649_1237750_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0814210_0814311_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1220484_1220585_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2632526_2632603_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1156108_1156209_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3744466_3744567_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3531374_3531475_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1298847_1298948_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3182941_3183042_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1285088_1285189_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3842801_3842902_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1242067_1242168_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3353378_3353479_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1233992_1234093_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2689692_2689793_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1187843_1187944_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1214408_1214509_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1148352_1148453_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2196063_2196164_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0358200_0358301_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1199095_1199196_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_330876_330977_lanthipeptide
Lanthipeptides: allorf_1251961_1252062_lanthipeptide
1
F Y Y R Q S C R R W R
11
F Y Y R Q S C R R W R
1
F Y Y R Q S C R R W R
11
5.9%
NZ_FMXV01000022.1:
Lanthipeptides: allorf_002190_002423_lanthipeptide
3
Y R Q S C R R W R
11
+ ++C R W R
57
W E R A C S R W R
65
allorf_2702843_2703025
Leader:
MKGGEIWNMKENFSALYETSEQELRELIGG
Core:
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb I P I Dhb N H V Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_2702843_2703025

100.0%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
93.3%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
70.0%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
Q N +S I T T I P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 4 more sequence matches
26.7%
NZ_CP023711.1 and 11 others:
NZ_CP034141.1 Lanthipeptides: EGM68_RS25880_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS26165_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS03920_lanthipeptide NZ_CP071875.1 Lanthipeptides: J4I02_RS05145_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS04795_lanthipeptide NZ_CP092831.1 Lanthipeptides: MLD56_RS04795_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS17805_lanthipeptide NZ_JAFJXZ010000012.1 Lanthipeptides: JYU28_RS03620_lanthipeptide NZ_JAKVDC010000009.1 Lanthipeptides: MKN04_RS18550_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS25810_lanthipeptide NZ_POVT01000017.1 Lanthipeptides: C1T20_RS25545_lanthipeptide
Lanthipeptides: CPY53_RS19275_lanthipeptide
7
T T I P I T N H V C P T I T V G C
23
T T I ++ V C T+T C
6
T T I K V S K A V C K T L T C I C
22
23.3%
NZ_CP063142.1 and 7 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T
18
+ ++ T I P I+ C P T
3
E R A I W T V T I P I S L A A C P T
20
20.6%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
8
T I P I T N H V C P T
18
T I P I+ +C P T
11
T I P I S A A I C P T
21
20.6%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
8
T I P I T N H V C P T
18
T I P I+ C P T
12
T I P I S A A A C P T
22

#### MIBiG 4.0 matches for allorf_2702843_2703025

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23

#### Lanthipeptide(s) for KH277_RS12980

KH277_RS12965
Leader:
MKKDFQALTPMTEEELKNLAGG
Core:
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha D A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for KH277_RS12965

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
94.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
D A T P T P T T I I P+S L A C P T T C S S P C
1
E D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
63.2%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S D P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29
55.6%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide
Lanthipeptides: MFF31_RS04085_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S C N
6
T I I I P I S L A A C P T T R C A S I V S S C N
29
55.6%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T+C A S I V C N
8
T P A T I-I P V S L A I C P T T R C A S I V E S C N G
34

#### MIBiG 4.0 matches for KH277_RS12965

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
KH277_RS12970
Leader:
MKKEFLALELMTEEELKELAGG
Core:
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
Core with dehydrations:
Dha E A Dhb P M Dhb V Dhb P Dhb Dhb I Dhb I P I Dha L A G Cys P Dhb Dhb K Cys A Dha I V Dha P Cys N D

#### antiSMASH-DB 4.0 matches for KH277_RS12970

100.0%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide
Lanthipeptides: U722_RS19990_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NC_023073.1 and 71 others:
NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptide
Lanthipeptides: U722_RS19995_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
97.2%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptide
Lanthipeptides: J7E20_RS10240_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S E A T P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S E A T P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
with 60 more sequence matches
Only the first 10 are displayed here.
91.7%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptide
Lanthipeptides: J7E20_RS10245_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+A P M T+T P T T I T I P I S L A G C P T T K C A S I V S P C N D
1
S D A A P M T I T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
66.7%
NZ_JAMDLZ010000027.1:
Lanthipeptides: M5W82_RS15520_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T+T I P I S L A G C P T T K C A S I V S P C
8
T P L T V T I P I S L A G C P T T K C A S I V S P C K G
35
63.9%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide
Lanthipeptides: WH45_RS23705_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N
35
+E+T P T P T I I P+S L A C P T T+C A S I V C N
1
A E S T P-N G T P A T I-I P V S L A I C P T T R C A S I V E S C N
33
61.1%
NZ_CP063142.1 and 5 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21455_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N D
36
T+T I P I S L A C P T T+C A S I V S P C N D
8
T V T I P I S L A A C P T T Q C A S I V S P C N D
32
61.1%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide
Lanthipeptides: B2C77_RS21505_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N D
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N D
33
61.1%
NZ_WIXN01000006.1 and 1 other:
NZ_WIXN01000006.1 Lanthipeptides: GHD25_RS06900_lanthipeptide
Lanthipeptides: GHD25_RS06900_lanthipeptide
2
E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C
34
+A T P T P T T I I P+S L A C P T T C S S P C
2
D A T P D T-H P T T I-I P V S L A V C P T T T C R S F S S P C
32
60.5%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide
Lanthipeptides: G475_RS0114655_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V E P C N D
38
60.5%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15255_lanthipeptide
Lanthipeptides: BM124_RS15255_lanthipeptide
1
S E A T P M T V T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
S+ P + T T+T I P I S G C P T T K C A S+V P C N D
3
S D Q Q P A S H P T T T V T I P I S A W G C P T T K C A S V V K P C N D
38
58.3%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide
Lanthipeptides: KJS43_RS18000_lanthipeptide
9
T P T T I T I P I S L A G C P T T K C A S I V S P C N D
36
T P T I I P+S L A C P T T K C A S+V P C N
7
T P A T I-I P V S L A I C P T T K C A S V V K P C N G
33
58.3%
NZ_BQME02000001.1 and 3 others:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide
Lanthipeptides: MFF31_RS04090_lanthipeptide
12
T I T I P I S L A G C P T T K C A S I V S P C N
35
T I I P I S L A C P T T+C A S I V S P C N
6
T I I I P I S L A A C P T T R C A S I V S P C N
29

#### MIBiG 4.0 matches for KH277_RS12970

24.3%
BGC0001229.4 (SBI_06989):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
13
I T I P I S L A G C P T T K C A S
29
+ + +S A C P T T K C S
19
V A V G V S A A F C P T T K C T S
35
19.4%
BGC0002110.3 (QKV49894.1):
Lanthipeptide: birimositide
22
C P T T K C A S
29
C P T T K C S
17
C P T T K C T S
24
KH277_RS12985
Leader:
MNEKMYRFAGDLREELEEISLS
Core:
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
Core with dehydrations:
E F Dha G G G G A E Q R G I Dha Q G N D G K L Cys Dhb L Dhb W E Cys G L Cys P Dhb H Dhb Cys W Cys

#### antiSMASH-DB 4.0 matches for KH277_RS12985

100.0%
NC_023073.1 and 65 others:
NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide
Lanthipeptides: U722_RS06170_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
97.4%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide
Lanthipeptides: J7E20_RS10220_lanthipeptide
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C+C
1
E F S G G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C F C
38
86.8%
NZ_CP016371.1 and 7 others:
NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide NZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide
Lanthipeptides: A5891_RS06120_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
1
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
33
with 92 more sequence matches
Only the first 10 are displayed here.
71.1%
NZ_BQME02000001.1 and 1 other:
NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide
Lanthipeptides: MFF31_RS04105_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C-W C
38
A E Q R G I S Q G N D G K C T L T W E C +C P T T C W C
1
A E Q R G I S Q G N D G K Y C T L T W E C S V C P T L T C F W C
32
68.4%
NZ_CP063142.1 and 10 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptide NZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide
Lanthipeptides: HPB58_RS21475_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E Q R G I S Q G N D G C T+T W E C +C P T H T C W C
1
A E Q R G I S Q G N D G H Q C T I T W E C S I C P T H T C W C
31
68.4%
NZ_FOXD01000022.1 and 1 other:
NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide
Lanthipeptides: BM124_RS15270_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E R G I S Q G N D G C T+T W E C G+C P T H T C W C
3
A E P R G I S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
68.4%
NZ_KQ040792.1 and 1 other:
NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide
Lanthipeptides: WH45_RS23330_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E +G+S Q G N D G K+C T L T W E C G L C P T H T C+C
1
A E V Q G L S Q G N D G K V C T L T W E C G L C P T H T C F C
31
65.8%
NZ_BOSN01000007.1 and 3 others:
NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide NZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide
Lanthipeptides: KJS43_RS18005_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
32
65.8%
NZ_LT745762.1 and 1 other:
NZ_LT745762.1 Lanthipeptides: B2C77_RS00795_lanthipeptide
Lanthipeptides: B2C77_RS00795_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A A E P M G I S Q G N D G K W C T V T W E C S I C P T H T C W C
32
63.2%
NZ_AUCI01000015.1 and 1 other:
NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide
Lanthipeptides: G475_RS0114640_lanthipeptide
6
G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
E R G+S Q G N D G C T+T W E C G+C P T H T C W C
1
A D V E T R G L S Q G N D G D Y C T I T W E C G M C P T H T C W C
33
63.2%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide
Lanthipeptides: NP440_RS09135_lanthipeptide
7
G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A E G I S+ N D G K C T L T W E C +C P T H T C W C
1
A A E P M G I S E D N D G K Y C T L T W E C S I C P T H T C W C
32
63.2%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide
Lanthipeptides: BK581_RS07320_lanthipeptide
8
A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W C
38
A+ +G I S Q G N D G K C T+T W E C +C P T H T C W C
1
A D V Q G I S Q G N D G K Y C T I T W E C S I C P T H T C W C
31
55.3%
NZ_CP040417.1 and 7 others:
NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide
Lanthipeptides: FE328_RS09040_lanthipeptide
5
G G G A E Q R G I S Q G N D G K L C T L T W E C G L C P T H T C W
37
G G R +S+G N G K+C T L T W E C G+C P+H T C+
1
G V G K W I R K L S K G N T G K V C T L T W E C G I C P S H T C F
33

#### MIBiG 4.0 matches for KH277_RS12985

23.7%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G N D G K L C T L T W E C
28
G N G C T L T E C
11
G N K G A Y C T L T V E C
23
23.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G N D G K L C T L T W E C
28
G N+G C T L T E C
13
G N N G G W C T L T K E C
25
15.8%
BGC0000580.3 (EGD17355.1):
Lasso peptide: xanthomonin II or xanthomonin I
6
G G A E Q R G I S Q
15
G G G I S Q
10
G G I T T L G I S Q
19
with 1 more sequence matches
12.8%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
22
C T L T W E C
28
C T L+ E C
28
C T L S K E C
34
allorf_2702843_2703025
Leader:
MKGGEIWNMKENFSALYETSEQELRELIGG
Core:
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
Core with dehydrations:
Q N Dha V Dha I Dhb Dhb I P I Dhb N H V Cys P Dhb I Dhb V G Cys A Cys P Q R Q V

#### antiSMASH-DB 4.0 matches for allorf_2702843_2703025

100.0%
NC_023073.1 and 18 others:
NZ_CP010556.1 Lanthipeptides: allorf_1170865_1171047_lanthipeptide NZ_CP016395.1 Lanthipeptides: allorf_1266893_1267075_lanthipeptide NZ_CP023133.1 Lanthipeptides: allorf_0800979_0801161_lanthipeptide NZ_CP025341.1 Lanthipeptides: allorf_1207246_1207428_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP028440.1 Lanthipeptides: allorf_1169247_1169429_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP031694.1 Lanthipeptides: allorf_3757607_3757789_lanthipeptide NZ_CP065790.1 Lanthipeptides: allorf_1228836_1229018_lanthipeptide NZ_CP072310.1 Lanthipeptides: allorf_3340146_3340328_lanthipeptide NZ_CP074685.1 Lanthipeptides: allorf_1220760_1220942_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP075054.1 Lanthipeptides: allorf_2702843_2703025_lanthipeptide NZ_CP088300.1 Lanthipeptides: allorf_1174611_1174793_lanthipeptide NZ_CP090905.1 Lanthipeptides: allorf_1201177_1201359_lanthipeptide NZ_CP094618.1 Lanthipeptides: allorf_1135121_1135303_lanthipeptide NZ_CP119675.1 Lanthipeptides: allorf_2182837_2183019_lanthipeptide NZ_LN999829.1 Lanthipeptides: allorf_1186077_1186259_lanthipeptide
Lanthipeptides: allorf_1238739_1238921_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
93.3%
NZ_CP016371.1 and 25 others:
NZ_CP017775.1 Lanthipeptides: allorf_1362373_1362555_lanthipeptide NZ_CP018295.1 Lanthipeptides: allorf_1224462_1224620_lanthipeptide NZ_CP023075.1 Lanthipeptides: allorf_1280618_1280800_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP027429.1 Lanthipeptides: allorf_2645650_2645832_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP033967.1 Lanthipeptides: allorf_3544503_3544661_lanthipeptide NZ_CP035393.1 Lanthipeptides: allorf_1361512_1361694_lanthipeptide NZ_CP044133.1 Lanthipeptides: allorf_1285659_1285817_lanthipeptide NZ_CP044444.1 Lanthipeptides: allorf_2620740_2620922_lanthipeptide NZ_CP048002.1 Lanthipeptides: allorf_3117293_3117475_lanthipeptide NZ_CP059405.1 Lanthipeptides: allorf_3169717_3169899_lanthipeptide NZ_CP059495.1 Lanthipeptides: allorf_1271882_1272064_lanthipeptide NZ_CP064091.1 Lanthipeptides: allorf_3829595_3829777_lanthipeptide NZ_CP083716.1 Lanthipeptides: allorf_104358_104540_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP092110.1 Lanthipeptides: allorf_0710754_0710936_lanthipeptide NZ_CP116013.1 Lanthipeptides: allorf_0410910_0411092_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAJNPN010000001.1 Lanthipeptides: allorf_107486_107668_lanthipeptide NZ_JAQEMJ010000002.1 Lanthipeptides: allorf_050414_050596_lanthipeptide NZ_KB206086.1 Lanthipeptides: allorf_0467875_0468057_lanthipeptide NZ_KN050798.1 Lanthipeptides: allorf_0345012_0345170_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide NZ_PVRO01000002.1 Lanthipeptides: allorf_344018_344200_lanthipeptide
Lanthipeptides: allorf_1203980_1204162_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
Q N S V S I T T P I T N H+C P T I T V G C A C P Q R Q V
1
Q N S V S I T T Y P I T N H I C P T I T V G C A C P Q R Q V
30
70.0%
NZ_JAGGQH010000006.1 and 1 other:
NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10235_lanthipeptide
Lanthipeptides: J7E20_RS10235_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T I T V G C A C P Q R Q V
30
Q N +S I T T I P T H+C T+T V G C A C P Q+Q+
1
Q N L I S I T T I P F T-H L C A T V T V G C A C P Q K Q I
29
with 4 more sequence matches
26.7%
NZ_CP023711.1 and 11 others:
NZ_CP034141.1 Lanthipeptides: EGM68_RS25880_lanthipeptide NZ_CP040829.1 Lanthipeptides: FGY93_RS26165_lanthipeptide NZ_CP049598.1 Lanthipeptides: G7L40_RS03920_lanthipeptide NZ_CP071875.1 Lanthipeptides: J4I02_RS05145_lanthipeptide NZ_CP086373.1 Lanthipeptides: LMH85_RS04795_lanthipeptide NZ_CP092831.1 Lanthipeptides: MLD56_RS04795_lanthipeptide NZ_CP102865.1 Lanthipeptides: NWS42_RS17805_lanthipeptide NZ_JAFJXZ010000012.1 Lanthipeptides: JYU28_RS03620_lanthipeptide NZ_JAKVDC010000009.1 Lanthipeptides: MKN04_RS18550_lanthipeptide NZ_JWJJ01000002.1 Lanthipeptides: U707_RS25810_lanthipeptide NZ_POVT01000017.1 Lanthipeptides: C1T20_RS25545_lanthipeptide
Lanthipeptides: CPY53_RS19275_lanthipeptide
7
T T I P I T N H V C P T I T V G C
23
T T I ++ V C T+T C
6
T T I K V S K A V C K T L T C I C
22
23.3%
NZ_CP063142.1 and 7 others:
NZ_CP063142.1 Lanthipeptides: HPB58_RS21460_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide NZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide
Lanthipeptides: HPB58_RS21460_lanthipeptide
1
Q N S V S I T T I P I T N H V C P T
18
+ ++ T I P I+ C P T
3
E R A I W T V T I P I S L A A C P T
20
20.6%
NZ_CP101913.1 and 1 other:
NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide
Lanthipeptides: NP440_RS09140_lanthipeptide
8
T I P I T N H V C P T
18
T I P I+ +C P T
11
T I P I S A A I C P T
21
20.6%
NZ_KV917378.1 and 1 other:
NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide
Lanthipeptides: BK581_RS20095_lanthipeptide
8
T I P I T N H V C P T
18
T I P I+ C P T
12
T I P I S A A A C P T
22

#### MIBiG 4.0 matches for allorf_2702843_2703025

13.3%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
18
T I T V G C
23
T+T V C
18
T L T V E C
23

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 25.28 out of 27.78
Confidence: strong
LexA variant 2
Description: Repressor of DNA damage response
Species: Bacillus subtilis subsp. subtilis str. 168
Score: 23.52 out of 24.78
Confidence: strong
AfsR
Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.38 out of 26.06
Confidence: medium
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 18.57 out of 20.01
Confidence: medium
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.70 out of 29.25
Confidence: medium
Additional weak hits (3):
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.13 out of 30.22
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.46 out of 30.11
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 20.85 out of 30.22
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

KH277_RS12895 - Class II
  Cleavage pHMM score: -7.30
  RODEO score: 0
  Monoisotopic mass: 4023.2 Da
  Molecular weight: 4025.7 Da
  Number of bridges: 2
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    4043.7 Da N = 1
KH277_RS12965 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
KH277_RS12970 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
KH277_RS12985 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
allorf_2689692_2689793 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 1601.8 Da
  Molecular weight: 1602.8 Da
  Number of bridges: 1
allorf_2702843_2703025 - Class II
  Cleavage pHMM score: 2.70
  RODEO score: 0
  Monoisotopic mass: 3053.6 Da
  Molecular weight: 3055.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3073.5 Da N = 1
    3091.6 Da N = 2
    3109.6 Da N = 3
    3127.6 Da N = 4
KH277_RS12965 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3389.7 Da
  Molecular weight: 3391.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3409.9 Da N = 1
    3427.9 Da N = 2
    3446.0 Da N = 3
    3464.0 Da N = 4
    3482.0 Da N = 5
    3500.0 Da N = 6
    3518.0 Da N = 7
    3536.1 Da N = 8
    3554.1 Da N = 9
KH277_RS12970 - Class II
  Cleavage pHMM score: 3.30
  RODEO score: 0
  Monoisotopic mass: 3403.7 Da
  Molecular weight: 3405.9 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3423.9 Da N = 1
    3442.0 Da N = 2
    3460.0 Da N = 3
    3478.0 Da N = 4
    3496.0 Da N = 5
    3514.0 Da N = 6
    3532.1 Da N = 7
    3550.1 Da N = 8
    3568.1 Da N = 9
KH277_RS12985 - Class II
  Cleavage pHMM score: -4.60
  RODEO score: 0
  Monoisotopic mass: 3892.7 Da
  Molecular weight: 3895.3 Da
  Number of bridges: 5
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3913.3 Da N = 1
allorf_2702843_2703025 - Class II
  Cleavage pHMM score: 2.70
  RODEO score: 0
  Monoisotopic mass: 3053.6 Da
  Molecular weight: 3055.5 Da
  Number of bridges: 3
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3073.5 Da N = 1
    3091.6 Da N = 2
    3109.6 Da N = 3
    3127.6 Da N = 4

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AfsR | Pleiotropic regulatory for antibiotic production
ArgR | Regulator of arginine biosynthesis genes
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
LexA variant 2 | Repressor of DNA damage response
MogR | Repressor of flagellar motility genes
SypG | Regulator of biofilm formation and host colonization

NZ_CP075054.1 - Region 11 - terpene
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,886,389 - 2,907,129 nt. (total: 20,741 nt) Show pHMM detection rules used
terpene: (PT_phytoene_like or phytoene_synt or Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA or TS_Pyr4)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
KH277_RS14090: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Hydrolases: hydrolase
KH277_RS14115: asparagine synthase (glutamine-hydrolyzing)

smcogs
  SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.3 |  | 0.46 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001374.5 |  | 0.38 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000645.3 |  | 0.38 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0002285.2 |  | 0.33 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.33 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.33 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0002339.3 |  | 0.33 | terpene | 2-hydroxysorangiadenosine | Vitiosangium cumulatum
BGC0001007.5 |  | 0.32 | NRPS, PKS | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000885.3 |  | 0.46 | other (other) | 4-hydroxy-3-nitrosobenzamide | Streptomyces murayamaensis
BGC0000846.5 |  | 0.44 | other (other) | tabtoxin | Pseudomonas syringae
BGC0001880.3 |  | 0.41 | ribosomal | scytodecamide | Scytonema sp. UIC 10036
BGC0001374.5 |  | 0.38 | other (other) | thienodolin | Streptomyces albogriseolus
BGC0000645.3 |  | 0.38 | terpene | carotenoid | Halobacillus halophilus DSM 2266
BGC0002285.2 |  | 0.33 | ribosomal | aborycin | Streptomyces sp. ZS0098
BGC0001810.3 |  | 0.33 | PKS | trehangelin | Polymorphospora rubra
BGC0001735.5 |  | 0.33 | other (other) | pentostatine, vidarabine | Streptomyces antibioticus
BGC0002339.3 |  | 0.33 | terpene | 2-hydroxysorangiadenosine | Vitiosangium cumulatum
BGC0001007.5 |  | 0.32 | NRPS, PKS | lymphostin, neolymphostinol B, lymphostinol, neolymphostin b | Salinispora arenicola CNS-205

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
triterpene | C30 carotenoid | diapophytoene | C30 | acyclic | none
triterpene |  | squalene | C30 | acyclic | none
triterpene |  | PSPP | C30 | acyclic | PP
tetraterpene | C40 carotenoid | phytoene | C40 | acyclic | none
triterpene |  | hydroxysqualene | C30 | acyclic | OH

Genes with terpene domains:
KH277_RS14110: PT_phytoene_like
Domain 1 (3 - 242): Prenyltransferase; Phytoene synthase like
Subtype: unknown

Reactions:
  FPP → diapophytoene
  FPP → squalene
  FPP → PSPP
  GGPP → phytoene
  PSPP → hydroxysqualene

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 17.44 out of 20.97
Confidence: medium
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 23.16 out of 26.33
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.27 out of 28.19
Confidence: medium
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 26.99 out of 35.63
Confidence: medium
RutR
Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.10 out of 26.85
Confidence: medium
Additional weak hits (2):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.44 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.16 out of 26.06
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
FPP | Farnesyl diphosphate
GGPP | Geranylgeranyl diphosphate
PP | Diphosphate
PSPP | Presqualene diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
ANR | Anaerobic transcriptional regulator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
NrtR | NAD synthesis repressor
RutR | Regulator of the pyrimidine and purine metabolism
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 12 - PKS-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 2,989,144 - 3,030,388 nt. (total: 41,245 nt) Show pHMM detection rules used
PKS-like: (t2pks2 or ksIII)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
KH277_RS14745: short-chain dehydrogenase/reductase SDR

smcogs
  SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: acyltransferase aminotransferase
KH277_RS14700: aminotransferase

smcogs
  SMCOG1019: aminotransferase

KH277_RS14715: acyltransferase

smcogs
  SMCOG1141: acyltransferase

Hydrolases: deacetylase
KH277_RS14655: polysaccharide deacetylase

smcogs
  SMCOG1235: polysaccharide deacetylase

Ligases: synthase
KH277_RS14695: Beta-ketoacyl synthase

smcogs
  SMCOG1022: Beta-ketoacyl synthase

Translocases: permease
KH277_RS14740: phenylalanine-specific permease

smcogs
  SMCOG1038: phenylalanine-specific permease

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | PKS-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002276.2 |  | 0.55 | NRPS | choline | Aspergillus nidulans FGSC A4
BGC0001928.2 |  | 0.50 | other (other) | (2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid | Streptomyces sp. MA37
BGC0002404.2 |  | 0.45 | other (other) | falcarindiol | Solanum lycopersicum
BGC0002294.3 |  | 0.44 | other (other) | streptozotocin | Streptomyces achromogenes subsp. streptozoticus
BGC0000205.3 |  | 0.43 | PKS | bryostatin | Candidatus Endobugula sertula
BGC0002150.2 |  | 0.42 | ribosomal | triculamin | Streptomyces triculaminicus
BGC0002151.2 |  | 0.42 | ribosomal | alboverticillin | Streptomyces griseocarneus
BGC0001292.5 |  | 0.42 | other (other) | A33853 | Streptomyces sp. NRRL 12068
BGC0001206.5 |  | 0.42 | other (other) | indolmycin | Streptomyces griseus subsp. griseus
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.49 out of 25.88
Confidence: medium
IolR
Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.50 out of 23.79
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.52 out of 26.06
Confidence: medium
GnfM
Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 25.91 out of 27.55
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.88 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.01 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.81 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.75 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.31 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 20.83 out of 28.19
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 24.27 out of 28.19
Confidence: medium
Additional weak hits (9):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.59 out of 30.11
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.41 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.75 out of 26.06
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.34 out of 30.25
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.28 out of 28.14
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.48 out of 29.38
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 21.02 out of 28.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 22.32 out of 33.14
Confidence: weak
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM | Regulator of nitrogen-fixation genes
IolR | Regulator of the inositol catabolism
MogR | Repressor of flagellar motility genes
PsrA | Oleic acid responsive regulator
ZuR variant 1 | Zinc-responsive repressor

NZ_CP075054.1 - Region 13 - NRPS
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 3,566,060 - 3,631,467 nt. (total: 65,408 nt) Show pHMM detection rules used
NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
NRPS/PKS modules
NRPS/PKS domains
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase oxidoreductase reductase
KH277_RS17555: oxidoreductase

smcogs
  SMCOG1083: oxidoreductase

KH277_RS17710: alcohol dehydrogenase

smcogs
  SMCOG1040: alcohol dehydrogenase

KH277_RS17720: pyridine nucleotide-disulfide oxidoreductase

smcogs
  SMCOG1175: pyridine nucleotide-disulfide oxidoreductase

KH277_RS17735: alkyl hydroperoxide reductase subunit

smcogs
  SMCOG1176: alkyl hydroperoxide reductase subunit

KH277_RS17750: aldehyde dehydrogenase

smcogs
  SMCOG1017: aldehyde dehydrogenase

Transferases: PPTase aminotransferase
KH277_RS17635: 4'-phosphopantetheinyl transferase

smcogs
  SMCOG1012: 4'-phosphopantetheinyl transferase

KH277_RS17640: aminotransferase

smcogs
  SMCOG1019: aminotransferase

Hydrolases: esterase
KH277_RS17645: thioesterase

smcogs
  SMCOG1004: thioesterase

Ligases: ligase synthase
KH277_RS17650: condensation domain-containing protein

smcogs
  SMCOG1127: condensation domain-containing protein

KH277_RS17660: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS17715: cobalamin synthesis protein/P47K family protein

smcogs
  SMCOG1178: cobalamin synthesis protein/P47K family protein

KH277_RS19320: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

KH277_RS19405: AMP-dependent synthetase and ligase

smcogs
  SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | NRPS | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.82 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000433.5 |  | 0.82 | NRPS | surfactin | Bacillus velezensis FZB42
BGC0001833.4 |  | 0.75 | NRPS | icosalide A, icosalide B | Burkholderia gladioli
BGC0002135.2 |  | 0.74 | NRPS | bovienimide A | Xenorhabdus bovienii SS-2004
BGC0002075.3 |  | 0.73 | NRPS | pyreudione A, pyreudione B, pyreudione C, pyreudione D, pyreudione E | Pseudomonas fluorescens
BGC0002286.3 |  | 0.73 | NRPS | ririwpeptide A, ririwpeptide B, ririwpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001128.4 |  | 0.73 | NRPS | gamexpeptide C | Photorhabdus laumondii subsp. laumondii TTO1
BGC0001132.4 |  | 0.73 | NRPS | xenotetrapeptide | Xenorhabdus nematophila ATCC 19061
BGC0001135.5 |  | 0.73 | NRPS | bicornutin A1, bicornutin A2 | Xenorhabdus budapestensis
BGC0001758.4 |  | 0.72 | NRPS | rhizomide A, rhizomide B, rhizomide C | Paraburkholderia rhizoxinica HKI 454
BGC0001825.4 |  | 0.72 | NRPS | xenematide | Xenorhabdus nematophila AN6/1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 18.07 out of 18.16
Confidence: strong
ToxT
Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.42 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.88 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.41 out of 26.06
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 20.50 out of 27.78
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.06 out of 26.06
Confidence: medium
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.40 out of 20.97
Confidence: medium
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 25.55 out of 29.38
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 21.30 out of 27.78
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 23.65 out of 28.19
Confidence: medium
Additional weak hits (21):
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.88 out of 31.73
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 19.92 out of 26.06
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.35 out of 30.25
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 21.56 out of 31.73
Confidence: weak
HgtR
Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 22.63 out of 36.54
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.38 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.21 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.26 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 21.14 out of 26.06
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.29 out of 26.06
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.40 out of 29.38
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 21.38 out of 29.38
Confidence: weak
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 20.40 out of 26.06
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 21.98 out of 29.25
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 25.74 out of 32.74
Confidence: weak
FuR variant 1
Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38
Confidence: weak
HexR
Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 22.17 out of 31.73
Confidence: weak
ColR
Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 21.42 out of 30.25
Confidence: weak
NrtR
Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 22.50 out of 35.63
Confidence: weak
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.79 out of 20.01
Confidence: weak
SypG
Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 22.06 out of 29.25
Confidence: weak
Module view
Shows module structures for each candidate cluster in NRPS and PKS regions.
Genes are shown in predicted order, and are only present when containing at least one complete module.
A domain glossary is available here, and an explanation of the visualisation is available here.
Legend
Detailed domain annotation
Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
A domain glossary is available here, and an explanation of the visualisation is available here.
Selected features only
Show module domains
NRPS/PKS products
NRPS/PKS substrates
TFBS Finder
Predicted core structure(s)
Shows estimated product structure and polymer for each candidate cluster in the region. To show the product, click on the expander or the candidate cluster feature drawn in the overview.
For candidate cluster 18, location 3566059 - 3631467:
Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:
  (Glu - Leu - D-Leu) + (Val) + (Asp - D-Leu) + (Leu)

Direct lookup in NORINE database: strict or relaxed
Link to NORINE database query form
NRPS/PKS substrate predictions
Shows the predicted substrates for each adenylation domain and acyltransferase within genes. Each gene prediction can be expanded to view detailed predictions of each domain. Each prediction can be expanded to view the predictions by tool (and, for some tools, further expanded for extra details).
KH277_RS17650: Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (469..867): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHVSFDAFTFDAFALFGGEINCYGPTEGTVFATA
  Nearest Stachelhaus code(s):
    Leu DAFFLGCVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS19405: Asp - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (437..839): Asp
nrpys: Asp

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    asp,asn (Asp, Asn)
  Single AA prediction:
    asp (Asp)

Stachelhaus prediction details:
  Stachelhaus sequence:
    YWFSFDLGYTAPKLVLGGEINHYGPTETTIGAIA
  Nearest Stachelhaus code(s):
    Asp DLTKVGHIGK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1482..1871): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS19320: Val
Search NORINE for peptide: strict or relaxed
AMP-binding (470..864): Val
nrpys: Val

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    val (Val)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LHSGFDAGTFEGWLIIGGDWNGYGPTENTTFSTS
  Nearest Stachelhaus code(s):
    Val DAFWIGGTFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

KH277_RS17660: Glu - Leu - Leu
Search NORINE for peptide: strict or relaxed
AMP-binding (465..867): Glu
nrpys: Glu

SVM prediction details:
  Predicted physicochemical class:
    hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
  Large clusters prediction:
    Aliphatic chain with H-bond donor (Asp, Asn, Glu, Gln, Aad)
  Small clusters prediction:
    glu,gln (Glu, Gln)
  Single AA prediction:
    gln (Gln)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LSLAFDASVKQADGLIGGETNVYGPTETCVDASV
  Nearest Stachelhaus code(s):
    Glu DAKDLGVVDK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (1511..1908): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    TNTSFDAFMFDGMIMFGGELHMYGPSESTVFATY
  Nearest Stachelhaus code(s):
    Leu DAFMMGMVFK (100% 8Å match)
  Stachelhaus code match:
    100% (strong)

AMP-binding (2550..2939): Leu
nrpys: Leu

SVM prediction details:
  Predicted physicochemical class:
    hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
  Large clusters prediction:
    Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
  Small clusters prediction:
    Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
  Single AA prediction:
    leu (Leu)

Stachelhaus prediction details:
  Stachelhaus sequence:
    LWHAFDASIWEPFLLVGGDVNNYGPTENTVVATS
  Nearest Stachelhaus code(s):
    Leu DAWFLGNVVK (97% 8Å match)
  Stachelhaus code match:
    100% (strong)

Link to PARAS substrate predictor
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CcpA | Catabolite control protein A
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
FuR variant 1 | Ferric Uptake Regulator
MogR | Repressor of flagellar motility genes
ToxT | Regulator of MSHA biosynthesis
ZuR variant 1 | Zinc-responsive repressor