LOCUS       NZ_AP023360            10825 bp    DNA     linear   CON 25-AUG-2024
DEFINITION  Catellatospora sp. IY07-71 chromosome.
ACCESSION   NZ_AP023360
VERSION     NZ_AP023360.1
KEYWORDS    RefSeq.
SOURCE      Catellatospora sp. IY07-71
  ORGANISM  Catellatospora sp. IY07-71
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Catellatospora.
REFERENCE   1
  AUTHORS   Komaki,H. and Tamura,T.
  TITLE     Whole genome shotgun sequence of Catellatospora sp. IY07-71
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8595826)
  AUTHORS   Ichikawa,N., Komaki,H., Tamura,T. and Uohara,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2020) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :https://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.4
            Genome Coverage                   :: 381x
            Sequencing Technology             :: SMRT cell 8 Pac V3
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018326265.1-RS_2024_08_25
            Annotation Date                   :: 08/25/2024 05:22:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,732
            CDSs (total)                      :: 7,655
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 20 of 92
            Pseudo Genes (incomplete)         :: 82 of 92
            Pseudo Genes (internal stop)      :: 2 of 92
            Pseudo Genes (multiple problems)  :: 12 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:09:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7949002
            Orig. end                         :: 7959827
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023360.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Annotated at DFAST https://dfast.nig.ac.jp/
FEATURES             Location/Qualifiers
     region          1..10825
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="27"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10825
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10825
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5825](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5825
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    164..178
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.34"
                     /tool="antismash"
     misc_feature    371..385
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 20.47"
                     /tool="antismash"
     misc_feature    612..623
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 17.04"
                     /tool="antismash"
     gene            complement(628..2052)
                     /locus_tag="CS0771_RS35600"
                     /old_locus_tag="CS0771_71770"
     CDS             complement(628..2052)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF022388.5"
                     /locus_tag="CS0771_RS35600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71770"
                     /product="DUF2637 domain-containing protein"
                     /protein_id="WP_212845080.1"
                     /transl_table=11
                     /translation="MDLGQLTATWVPTWVMVLVVSVLTASLLIGVPLARSAGMRRGRRL
                     AHPEAYGTRKERAKDTSLFLAALIPTLLVWLAVMGVSFIGLTGFAADVMGWDHWTNVLV
                     PLSLDGISISFGAWAFVAVKRGRHPGRAYKIVLAAATVSATLNFVHGRDKWSIWAGLYL
                     AFLSFAGMAMFHELLDQFMASYDDEVALKTRYPRFGQRWLYAPLSTFAARRAWIVYPPA
                     EGTRPTVRNALAHREDVREAKRQRRLHGALLVREEQQAKLVEVHAKAEVRRARTASWRG
                     GQVPGATPLVPHQPMSHQAATHPNGSPAHGLHQNGVHQNGSHQPGQHLVAPSQELPQTV
                     PYQPTPAEPPQPQEPAIRAPQVPERDERGTILDPALRGQLESVWSAPGGGREPMGHRPL
                     SDTSEITSRGMLNHIQEPVQRMIAEVLARGEEITPAHVREWAAREYGRTPSENWARNQI
                     KAARQRDTIGVDADLR"
     gene            2262..2834
                     /locus_tag="CS0771_RS35605"
                     /old_locus_tag="CS0771_71780"
     CDS             2262..2834
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018727348.1"
                     /locus_tag="CS0771_RS35605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71780"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_203746230.1"
                     /transl_table=11
                     /translation="MPRVSQDQLDARRHEILAAARACFARYGYEGATVRRLEQATGLSR
                     GAIFHHFRDKDSLFLAVAEDDAVEMAATVAANGLVQVMRDLLAHAADPDAAGWLGTQLE
                     VARRLRTDPAFAQRWAQHSEAIDTATRERLKRQASAGVLREDVPLDVLTHFLELAYDGL
                     VKRLAMGGSADDFGPVLDLIEETVRRR"
     misc_feature    complement(3081..3099)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 17.1"
                     /tool="antismash"
     gene            3266..4033
                     /gene="ddaH"
                     /locus_tag="CS0771_RS35610"
                     /old_locus_tag="CS0771_71790"
     CDS             3266..4033
                     /EC_number="3.5.3.18"
                     /GO_function="GO:0016403 - dimethylargininase activity
                     [Evidence IEA]"
                     /GO_process="GO:0000052 - citrulline metabolic process
                     [Evidence IEA]"
                     /GO_process="GO:0006525 - arginine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ddaH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020524274.1"
                     /locus_tag="CS0771_RS35610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71790"
                     /product="dimethylargininase"
                     /protein_id="WP_212845081.1"
                     /transl_table=11
                     /translation="MSNRTVALVREPGPRLPEGIVTHIGRSEVDLSLARAQHMAYADAL
                     ASAGWEVYPAPSADDCPDAVFVEDAVVVCEDLAVLTHPGAPERRPEIAGAETAVRELGL
                     RVAHITGPGTLDGGDVLQVGSTVYVGRGGRTNGEGIRQLRELLAPLGRTVIAVPLGEVL
                     HLKSAVTALPDGTFLALPHLVPVELFPAVRPVQEEGGCHVVPLGGDRVLLAASAPRTAE
                     LLADLGFTPVVVDIGEFEKLEGCVTCLSVLIRR"
     gene            4081..5004
                     /locus_tag="CS0771_RS35615"
                     /old_locus_tag="CS0771_71800"
     CDS             4081..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072015.1"
                     /locus_tag="CS0771_RS35615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71800"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_212845082.1"
                     /transl_table=11
                     /translation="MADTWGIPGPTFLALYAATAAVVLVATLVLRSRAFAGPERVRIDQ
                     LTPQHTAYLTGGPARAVYASLAFLRQHGVLESESSGRLRRTGGLPPGASPLDAAVLHAA
                     GNGVRSADLRTDHSVASALHTISADLERNGLAVSAETIARARRGPLLLLALAALGVVRV
                     IAGLANDRPVGFLVPLTIAVAVFGLILVSRRPVRTRATDRALADTRRHYAHLSPRMKPA
                     FSTYGPAQTALAVGLFGAAVLWAADPAFAGESAIPEEREDHGASGGWADGGSSGGDGGG
                     GGDSGGSSCGGGSSCGGGGCGGGCGG"
     gene            5001..5825
                     /locus_tag="CS0771_RS35620"
                     /old_locus_tag="CS0771_71810"
     CDS             5001..5825
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018223394.1"
                     /locus_tag="CS0771_RS35620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71810"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_212845083.1"
                     /sec_met_domain="DUF692 (E-value: 9.9e-78, bitscore: 259.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPLADRGVGIGWRPEIAGFVAGLPGLRFVEVIAESLPHSGELPD
                     SLAALRGAGVAVVPHGVKLSLGGAEPVDPHRVEHLAQAARATGAPLVSEHIAYVRAGGV
                     EAGHLLPLPRSREAVDAVVANVRRTTAELDVPLALEPIAALFDWPDDELTEAQFLTEIL
                     ERTGAGLLLDVANVYANARNRGEDPLDLLDRLPLERVAYVHVAGGRVRDGRYHDTHTDP
                     VPGEVLDLLAALCERQRPPAVLLERDGSYPPAAALRAELDALAGATGYPAIT"
     gene            5822..6307
                     /locus_tag="CS0771_RS35625"
                     /old_locus_tag="CS0771_71820"
     CDS             5822..6307
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013734920.1"
                     /locus_tag="CS0771_RS35625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71820"
                     /product="hypothetical protein"
                     /protein_id="WP_212845084.1"
                     /transl_table=11
                     /translation="MTGPARQPDPADQVGGLARRQEELVRSLVAGAVTPKGFDPGAVAA
                     TREALLRKRAEEVARHWPRLATSAAAHPGGWPAAFGAWAAGRAPQGSLRDGWDYARALP
                     PRDPAAARELALRELLWEYDGTTAPKPRRGPALRLHAGELFVRWRGRALTRNLRRAP"
     gene            complement(6417..8387)
                     /locus_tag="CS0771_RS35630"
                     /old_locus_tag="CS0771_71830"
     CDS             complement(6417..8387)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019900842.1"
                     /locus_tag="CS0771_RS35630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71830"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212845085.1"
                     /transl_table=11
                     /translation="MRVSFGGGPGGGMESLMRSMRRGQSVENRKIGKLTARRILGFARP
                     YRKEITIFLLTVVLAAVIGVVTPLLAGRVVNTIVPENGAPLAADAGRTVIVIALVIAAL
                     AVVSALLSLAERFYSSRIGEGLIYDLRTRVYDHVQRMPVQFFTRAQTGALVSRLNNDVL
                     GAQRAFTSTLSGVVGNIIQLILTAGVMLTLSWQITVLSLVMLPLFILPARRVGHRLAAI
                     TKESYDLDARMNATMTERFGVAGALLVKLFGRPEVEAGRFAERAGRVRDIGVQSAMYSR
                     TFFVAMMLVASLAQALVYGLGGWYAVQGVLDAGTVVALALLLVRLYGPITALSNVRVDV
                     MGALVSFDRVFEVLDLPPAIAERPDAVDVPPRAAKVEFRDVTFRYPAAAEISLASLEDV
                     ATLERAAAEPVLRGVSFTVEPGQLVALVGSSGAGKSTTSMLVSRMYDVTSGAVLVGDVD
                     VRDATLQSLRDTIGVVTQDAHLFHETIAENLRYAKPDATDDELWAALAAAQIDTLVRAT
                     PDGLDTVVGERGYRFSGGEKQRIAIARLLLKAPSIVILDEATAHLDSESEAAVQQALST
                     ALAGRTALVIAHRLSTVREADQILVLDGGRIVQRGTHEQLLAQGGLYADLYRTQFAATE
                     SPRTRQLSAVTDSPRLADTPA"
     gene            complement(8625..9377)
                     /locus_tag="CS0771_RS35635"
                     /old_locus_tag="CS0771_71840"
     CDS             complement(8625..9377)
                     /NRPS_PKS="Domain: ECH (9-239). E-value: 1.1e-51. Score:
                     167.4. Matches aSDomain:
                     nrpspksdomains_CS0771_RS35635_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023: enoyl-CoA hydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020521112.1"
                     /locus_tag="CS0771_RS35635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71840"
                     /product="enoyl-CoA hydratase/isomerase family protein"
                     /protein_id="WP_203741432.1"
                     /transl_table=11
                     /translation="MAATGFRMTVDGPVATVTLDRPEVRNAQTPQLWTGLAAAARGLAG
                     DVRVVVVRGEGRSFSAGLDLKVVQGGEFQELATLDPEECADRIAGFQQAFSWLRRPDLI
                     TIAAVQGHAIGAGFQLALACDLRIAADDALFAMAEVTLGLVPDLTGTKRLVELVGYARA
                     LELCVTGRRVGAAEADRIGLVNLVVPRDELDAAAADLADAVLAAPRDAVVEIKALLAAA
                     SGRGYAEQERAEREAQTRRIRDLAGLGE"
     aSDomain        complement(8661..9350)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_CS0771_RS35635_ECH.1"
                     /evalue="1.10E-51"
                     /label="CS0771_RS35635_ECH.1"
                     /locus_tag="CS0771_RS35635"
                     /protein_end="239"
                     /protein_start="9"
                     /score="167.4"
                     /tool="antismash"
                     /translation="VDGPVATVTLDRPEVRNAQTPQLWTGLAAAARGLAGDVRVVVVRG
                     EGRSFSAGLDLKVVQGGEFQELATLDPEECADRIAGFQQAFSWLRRPDLITIAAVQGHA
                     IGAGFQLALACDLRIAADDALFAMAEVTLGLVPDLTGTKRLVELVGYARALELCVTGRR
                     VGAAEADRIGLVNLVVPRDELDAAAADLADAVLAAPRDAVVEIKALLAAASGRGYAEQE
                     RAEREAQT"
     misc_feature    9372..9382
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(9423..9650)
                     /locus_tag="CS0771_RS35640"
                     /old_locus_tag="CS0771_71850"
     CDS             complement(9423..9650)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020510159.1"
                     /locus_tag="CS0771_RS35640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_71850"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_120315961.1"
                     /transl_table=11
                     /translation="MAATGTATTTEKGRRIVGTERQTLAKDLVKRYTSGESIRALAAST
                     GRSYGFIHRVLTESGVALRQRGGARRRKKA"
     misc_feature    9723..9737
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.41"
                     /tool="antismash"
ORIGIN
        1 acgctgggta tgccgatggt ggtcgcgccg ccgatgtcgg cctcggggct gtcaccgatc
       61 atccaggccc cgcgcagccg catccgggcc cgttccgcgg cgatctcgaa gatgcgcggg
      121 ttgggcttgc ggcagtcgac ctcctgcgag accacccagt cggcgacgaa gcggtccagg
      181 ccggtacgcc ggatcttcgc ctcctgctgg cgggtctcgc cgttcgtgac gatcaccggc
      241 acccagccgg cgtcggcggc gatgcgcagc gccgcaccga ccatcgggtc cagccgcgtg
      301 cactcgatct gcccctcgtg caactcctcg accaggtcga tcacggagtt gcgcagtcgg
      361 tagcggtcgc ggatcgcgtc ggccagatcc cagcgcgacg tgagaccgtc cgcgtcggcg
      421 tccaccagcc agtcgatgtc gtacgtcggg gcgctgatct cggacaggaa ccgagcaccc
      481 cacatccgga aggcgcctgc gcggtcgacc agtgtgttgt cgaggtccaa cagcaacaaa
      541 ggcacgcggg caccttacgt gactcaggac acgctggtga agccccccgc gtgccgaaac
      601 gacgcggaaa cgaaaacgat ctcgcgttta cctcagatcg gcgtcgaccc cgatggtgtc
      661 acgctgccgt gcagccttga tctggttcct ggcccagttc tcggacgggg tccggccgta
      721 ctccctggcc gcccactccc gcacgtgggc cggagtgatc tcctcgccgc gggcgagcac
      781 ctccgcgatc atccgctgga ccggctcctg gatgtggttg agcatgccgc gcgaggtgat
      841 ctcgctggtg tcggacagcg gccggtggcc catcggctcc cggccgccgc ccggggcgct
      901 ccacacggac tcgagctgac cccgcagcgc ggggtccagg atcgtgccgc gctcatcgcg
      961 ctcgggcacc tgcggtgccc ggatggccgg ttcctgcggc tggggcggct cggccggggt
     1021 cggctggtac ggcaccgtct ggggcagctc ctgcgacggc gcgacgaggt gctgccccgg
     1081 ctggtgggac ccgttctggt ggactccgtt ctggtggagg ccgtgcgcgg gtgatccgtt
     1141 cgggtgcgtg gcggcctggt gcgacatggg ctggtgcggc accagcggcg tggcgcccgg
     1201 cacctgtccc ccgcgccagc tcgccgtacg ggcccggcgc acctccgcct tcgcgtgcac
     1261 ctcgaccagc ttggcctgct gctcctcgcg caccagcagc gcaccgtgca ggcggcgctg
     1321 gcgcttggcc tcacgcacgt cctcgcggtg ggcgagcgcg ttgcgcacgg tcgggcgggt
     1381 gccctcggcg ggcgggtaca cgatccaggc gcggcgggcc gcgaaggtgg acagcggcgc
     1441 gtacagccag cgctggccga aacgcgggta gcgggtcttc agcgccacct cgtcgtcgta
     1501 gctggccatg aactggtcca gcagctcgtg gaacatcgcc atgcccgcga aggaaaggaa
     1561 ggcgaggtag aggccggccc agatggacca cttgtcccgg ccgtgcacga agttcagggt
     1621 ggccgacacg gtcgccgcgg cgagcacgat cttgtacgcc cggccggggt ggcggccgcg
     1681 cttgaccgcc acgaacgccc aggcgccgaa ggagatgctg atgccgtcca ggctcagcgg
     1741 caccagcacg ttggtccagt ggtcccagcc catgacgtcg gcggcgaagc cggtgaggcc
     1801 gatgaaggac acgcccatca cggcgagcca gaccagcagg gtcgggatga gcgcggcgag
     1861 gaacaggctg gtgtccttgg cccgctcctt gcgcgtgccg tacgcctccg gatgggccag
     1921 ccgcctgccc cgccgcatgc ccgccgaccg ggccagcggc acgccgatca gcagtgacgc
     1981 ggtcagcacc gacaccacca gcaccatcac ccaggtgggc acccaggtcg cggtcaactg
     2041 ccccagatcc acagctcgtt cctccccggc gggcaacgga cctgttggcc cgcaaccgat
     2101 ccgcctggcg tcgcctactg cccccggcgt tcaacgcgcc ggtggacgcg gaggattctt
     2161 ccatgcggcg gggacacgcg cgatgcgtcg cagatctgtc acgcatggtc aagccgtacg
     2221 tacggattgc atgtgtcccg ccgacctgcg aagatcggcc tgtgcccagg gtgagtcagg
     2281 accagctcga cgcgcgccgc cacgagatcc tcgccgcggc ccgagcctgc ttcgcccgct
     2341 acggctacga gggcgccacc gtgcgccggc tggagcaggc caccggcctg tcccgcggcg
     2401 ccatcttcca ccacttccgg gacaaggact cgctgttcct ggccgtggcc gaggacgacg
     2461 cggtcgagat ggccgccacc gtcgccgcca acggcctggt gcaggtgatg cgggacctgc
     2521 tcgcgcacgc cgccgacccg gacgcggcgg gctggctcgg cacccagctg gaggtggccc
     2581 ggcggctgcg caccgacccg gcgttcgcgc agcgctgggc gcagcactcg gaggcgatcg
     2641 acaccgccac ccgcgagcgc ctcaagcgcc aggcgtcggc gggcgtgctg cgcgaggacg
     2701 tgccgctgga cgtgctcacg cacttcctgg agctggcgta cgacgggttg gtcaagcggc
     2761 tggcgatggg cggctcggcc gacgacttcg ggccggtgct ggacctgatc gaggagacgg
     2821 tccgccgccg ctgaaccggt catccggtct cagaacggaa caaaccccag ggttccgcac
     2881 gggtgtgcgg gccggttgga caaaaccgga caacccctgg ggttcgggtg gctcccgtgg
     2941 attcgccaag ccgctgacac acggcctcga cgctccagtc gaacctttgg tatcgacaga
     3001 agtgcagtcg atgacagccg cttagcgggc agccacctca cgtgtcctgt agctactcaa
     3061 agctggacca cctcctttcc cgtgtaccgc cgacactatc cacgcgatca cgggatcgac
     3121 aagatatttt ctccgcgagc ctcggggcac tacagtgcgg caccatgggc gccctcaaac
     3181 cgtggcatct cgttctcagc agcgtctgct gcctggccgt cgtggcggtg gtcgcgctgg
     3241 tcgtcgtgct ggtaatgcgt aagagatgag caaccgcacc gtcgcgctgg tccgcgaacc
     3301 cggcccgcgc ctgcccgagg gcatcgtcac ccacatcggc cgcagcgagg tcgacctctc
     3361 cctggcccgc gcccagcaca tggcgtacgc cgacgcgctg gcctcggccg ggtgggaggt
     3421 ctatcccgcg ccgtcggccg acgactgccc cgacgccgtc ttcgtcgagg acgccgtggt
     3481 ggtctgcgag gacctggccg tgctgaccca ccccggcgcg cccgagcgcc gccccgagat
     3541 cgctggcgcc gagaccgccg tgcgcgagct gggcctgcgc gtcgcgcaca tcaccggccc
     3601 cggcaccctc gacggcggcg acgtgctgca ggtcggctcg accgtctacg tcggacgcgg
     3661 cgggcgcacc aacggcgagg gcatccgcca gctgcgcgag ctgctcgccc cgctgggccg
     3721 caccgtgatc gcggtgccgc tgggcgaggt gctgcacctg aagtcggcgg tcaccgcact
     3781 gcccgacggc accttcctgg ccctgccgca cctggtgccg gtggagctgt tccccgcggt
     3841 gcggccggtg caggaggagg gcggctgcca cgtggtgccg ctcggcggcg accgggtgct
     3901 gctggccgcg tccgcgccgc gcaccgccga gctgctggca gacctgggct tcacgccggt
     3961 ggtggtggac atcggcgagt tcgagaagct cgaaggctgc gtgacctgcc tgagcgtcct
     4021 gatccgccgt tagtggcggc catggtccat catgggagca ccctcgacga aggagctccc
     4081 atggcggaca cctggggcat ccccggcccc acgttcctgg cgctgtacgc cgccaccgcg
     4141 gccgtcgtgc tggtcgccac gctggtcctg cgctcccggg cgttcgcggg gccggagcgg
     4201 gtgcgcatcg accagctgac cccgcagcac accgcgtacc tcaccggcgg tcccgcgcgc
     4261 gccgtctacg cctcgctggc cttcctgcgc cagcacggcg tgctggagag cgagagctcg
     4321 ggccggctgc gccgcaccgg cgggctgccg cccggcgcga gcccgctcga cgcggccgtg
     4381 ctgcacgcgg cgggcaacgg cgtacgctcc gccgacctgc gcaccgacca cagcgtcgcg
     4441 tcggccctgc acaccatcag cgccgacctg gagcgcaatg ggctcgcggt cagcgcggag
     4501 acgatcgccc gcgcccgccg ggggccgctg ctgctgctcg cgctcgccgc gctgggcgtg
     4561 gtccgggtca tcgcgggcct ggccaacgac cgcccggtcg gcttcctggt gccgctcacc
     4621 atcgcggtcg ccgtgttcgg cctgatcctg gtctcccggc gcccggtgcg cacccgcgcc
     4681 accgaccgtg ccctggctga cacccgccgg cactacgccc acctgagccc gcgcatgaag
     4741 ccggcgttct cgacgtacgg cccggcgcag accgccctgg cggtcggcct gttcggcgcg
     4801 gcggtgctgt gggccgccga ccctgccttc gcgggcgaat ccgccatccc ggaggagcgg
     4861 gaggaccacg gcgcgagcgg cgggtgggcc gacggcggct cgtccggcgg ggacggcggt
     4921 ggcggcggcg acagcggcgg ctcgtcctgc ggcggcggca gcagctgcgg aggcggcggc
     4981 tgcggaggcg ggtgcggggg atgaccccct tggcggaccg gggcgtcggc atcggctggc
     5041 gccccgagat cgccgggttc gtcgccgggc tgcccggcct gcgcttcgtc gaggtgatcg
     5101 ccgagtcgct gccgcactcc ggcgagctgc ccgactccct ggccgcgctg cggggcgcgg
     5161 gcgtcgcggt ggtgccgcac ggggtgaagc tgtccctcgg cggcgcggag ccggtcgacc
     5221 cgcaccgtgt cgagcacctc gcccaggccg cccgcgccac cggcgccccc ctggtcagcg
     5281 agcacatcgc gtacgtgcgc gcgggcggcg tcgaggccgg gcacctgctg cccctgccgc
     5341 gcagccggga ggccgtcgac gcggtcgtcg ccaacgtgcg gcgcacgacc gccgagctgg
     5401 acgtgccgct ggcgctcgag ccgatcgcgg cgctgttcga ctggccggac gacgagctga
     5461 ccgaggccca gttcctcacc gagatcctcg agcggaccgg cgccgggctg ctgctcgacg
     5521 tcgccaacgt gtacgccaac gcgcgcaacc ggggcgagga cccgctcgac ctgctggacc
     5581 ggctgccgct ggagcgggtg gcgtacgtgc acgtcgcggg cggccgggtg cgcgacggcc
     5641 gctaccacga cacgcacacc gacccggtgc ccggagaggt gctggacctg ctcgcggcgc
     5701 tgtgcgagcg gcagcggccg cccgcggtgc tgctggagcg ggacggttcc tacccgcccg
     5761 ccgccgcgct gcgcgccgaa ctggacgcgc tggccggcgc gaccggatac ccggcgatca
     5821 catgaccggc cccgcccgcc agccggatcc ggccgaccag gtgggcggcc tcgcccggcg
     5881 tcaggaggag ctggtccgct cgctcgtcgc cggagcggtg accccgaagg gcttcgaccc
     5941 cggtgcggtg gcggcgaccc gggaggcgct gctgcgcaag cgcgcggagg aggtggcgcg
     6001 gcactggccc cggctggcca cctccgcggc ggcccacccc ggcggctggc ccgccgcgtt
     6061 cggggcctgg gcggccgggc gtgccccgca gggctcgctg cgcgacggct gggactacgc
     6121 ccgcgccctg ccgccccgcg accccgccgc cgcccgggag ctggcgctgc gcgagctgct
     6181 gtgggagtac gacggcacga ccgcgccgaa gccgagacgt ggcccggcgc tgcgcctcca
     6241 cgccggggaa ctcttcgtcc gctggcgcgg ccgcgccctc acccgcaacc tgcgccgcgc
     6301 cccctgaccg gtcccgccct gcctcgatcg tccgacttgc cgggcactcg ggcgtatctt
     6361 gagcgcgcat tcggccactc gccgggcaag tcggatgatc aagcccgcgt gacgggtcag
     6421 gcgggggtgt ccgcgaggcg tggggagtcc gtgacggcgc tgagctgccg ggttcgcggc
     6481 gactccgtcg ccgcgaactg ggtgcggtac aggtcggcgt agaggccgcc ctgggcgagc
     6541 agctgctcgt gggtgccgcg ctggacgatc cggccgccgt cgaggaccag gatctggtcg
     6601 gcctcgcgga cggtggacag ccggtgcgcg atgaccagcg cggtccggcc cgcgagcgcg
     6661 gtggacaggg cctgctgcac cgcggcctcg ctctcggagt ccaggtgcgc ggtggcctcg
     6721 tccaggatga cgatcgacgg ggccttcagc agcagccggg cgatggcgat gcgctgcttc
     6781 tcgccgccgg agaaccggta gccccgctcg cccaccaccg tgtcgaggcc gtcgggggtg
     6841 gcccggacca gggtgtcgat ctgcgcggcg gccagcgcgg cccacagctc gtcgtcggtg
     6901 gcgtcgggct tggcatagcg gaggttctcc gcgatggtct cgtggaacag gtgggcgtcc
     6961 tgggtgacca cgccgatggt gtcgcgcagc gactgcagcg tggcgtcgcg cacgtccacg
     7021 tcgccgacca gcaccgcgcc ggaggtcacg tcgtacatac ggctgaccag catcgaggtg
     7081 gtggacttgc ccgcgccgga cgagccgacg agcgcgacga gctgtcccgg ctcgacggtg
     7141 aacgagacgc cgcgcagcac cggctcggcg gcggcgcgct ccagggtcgc cacgtcctcc
     7201 agcgaggcca gggagatctc cgcggcggcc gggtagcgga aggtcacgtc ccggaactcg
     7261 accttcgccg cgcgcggcgg cacgtccacc gcgtcgggcc gctcggcgat cgcgggcggc
     7321 aggtcgagca cctcgaagac gcggtcgaag gagaccagcg cccccatcac gtcgacccgt
     7381 acgttcgaca gcgcggtgat cgggccgtag aggcgcacca gcagcagcgc gagggcgacg
     7441 acggtgcccg cgtccagcac gccctgtacg gcgtaccagc cgcccaggcc gtagacgagc
     7501 gcctgggcga gcgaggcgac cagcatcatg gcgacgaaga aggtgcgcga gtacatggcg
     7561 ctctgcacgc cgatgtcgcg cacccgcccg gcgcgctcgg cgaaccgccc cgcctcgacc
     7621 tccgggcggc cgaacagctt caccagcagc gcgccggcca ccccgaaccg ctcggtcatg
     7681 gtggcgttca tgcgcgcgtc gaggtcgtac gactccttgg tgatcgcggc gagccggtgc
     7741 cccacccggc gcgcgggcag gatgaacagc ggcagcatca ccagcgagag cacggtgatc
     7801 tgccaggaca gggtgagcat cacgccggcg gtgaggatca gctggatgat gttgccgacc
     7861 acgccggaca gcgtcgaggt gaacgcccgc tgggcgccca gcacgtcgtt gttgagccgg
     7921 ctgaccagcg cgccggtctg cgcccgggtg aagaactgca ccggcatccg ctgcacgtgg
     7981 tcgtacacgc gggtgcgcag gtcgtagatg agcccctcgc cgatccggct ggagtagaag
     8041 cgctcggcca gcgacagcag cgcgctgacc acggcgagcg ccgcgatgac cagcgcgatg
     8101 acgatcaccg tgcggcccgc gtcggcggcc agcggcgcgc cgttctccgg cacgatcgtg
     8161 ttgaccaccc ggcccgccag cagcggggtg accacgccga tgaccgcggc cagcacgacc
     8221 gtcagcagga agatcgtgat ctccttgcgg tacggccggg cgaagcccag gatccgccgc
     8281 gccgtcaact tgccgatctt gcggttctcc acgctctgcc cgcggcgcat cgaccgcatg
     8341 agcgattcca taccgccgcc ggggccgcca ccgaaactca cccgcatacc tccctctaag
     8401 ccctgccgtg ccggttaacg tgcggcgcgg agtgaaaatt ccttagccgg gcttattaac
     8461 tattccgccg tccggggcgc accagtcgcg cggtgtagtc gccggtccgg tggaatgagt
     8521 gggaaccatc ctttccacca tcgcgaatca gccatgggga ggacacccga aagggcgtat
     8581 caacgaacgc ggaaagggac gatcggcgtc ggggaggcgg attgctactc gcccagcccg
     8641 gccagatcgc ggatgcggcg ggtctgcgcc tcccgctcgg cgcgctcctg ctcggcatag
     8701 ccgcggccgc tcgccgcggc cagcagggcc ttgatctcga cgaccgcgtc ccgcggcgcg
     8761 gccagcaccg cgtcggccag atcggccgcg gccgcgtcca gctcgtcacg tggcaccacc
     8821 aggttgacca ggccgatccg gtccgcctcg gcggccccga cccggcgccc ggtcacgcag
     8881 agctccagcg cacgggcgta gccgaccagc tccaccaggc gtttggtgcc ggtgaggtcc
     8941 ggcacgagcc ccagcgtcac ctccgccatc gcgaagagcg cgtcgtcggc ggcgatccgc
     9001 aggtcacagg ccagcgcgag ctggaagccg gcgccgatgg cgtggccctg caccgccgcg
     9061 atggtgatga ggtcgggccg gcggagccag gagaaggcct gctggaaacc ggcgatccgg
     9121 tccgcgcact cctccgggtc gagcgtggcg agctcctgga actcgccgcc ctgcaccact
     9181 ttcaggtcga ggcccgcgga gaaggaccgc ccttctccgc gtacgaccac gacgcgcaca
     9241 tcgccggcaa gcccccgtgc ggccgcggca agacccgtcc agagctgcgg ggtctgcgcg
     9301 ttgcgcacct ccgggcggtc caatgtcacc gtcgcgacag gaccgtccac ggtcatgcga
     9361 aagccggtcg ctgccatgtc aggcatcggc cggctcccac tgctcggcgt ggcgcgggcg
     9421 aatcatgcct tcttgcgccg acgtgctccg ccgcgctgcc gcagcgcgac accggactcg
     9481 gtgagcaccc ggtggatgaa tccgtacgaa cggccagtcg acgcggccag cgcgcggatg
     9541 gactcacccg acgtgtagcg cttcacgagg tccttggcga gcgtctggcg ttcggtcccg
     9601 acgatccggc gacccttctc ggtggtggta gctgtgccgg tggctgccat gttgaaatcc
     9661 tcacgtcccg gacgatgcgg tatgcggtcc aacctattag accgcctccg acgatcatgc
     9721 gctagatatc aattccatgc caaccgacac gcacggtgct gtcgggtacc cgatagcgtg
     9781 tccgaccgtg accaccgctg accccctgag cacccgcgac cgcgaacggc gagacctgtt
     9841 cggctggttc gtgctggtgt gcatcggcct gctggcgacc tggctggcgg tgcgcggcgg
     9901 cgcccggctc ggcaccgcca gcgcgccgtt cctcggcagc taccgcttcg aattgtcgcc
     9961 ggcctcgctg ctggcgccgc tcgtcgcggt cgtcgtgctc ggcgccgcct ggcgcggctg
    10021 gatccatcga ctgccgtggt gggcggtgag caccggggcc accgtcgcgt tcttcgcgtg
    10081 ggccgtctcg ctcgccctcg tcgacggcgc cgacggcctg acccgctcgc tcaccccgga
    10141 cagctacctc ggtgacgtgc aggaggtcgg cgacgatccg ctggcgtacc tgagctcctt
    10201 cacgggccgc tcggccgagc acaccacggc gacccgcggc cacccgcccg cgccggtgct
    10261 gctgctgtgg gccgtgcagc ggctcggcgt caccgaccac ctcgcactgg gcctgctggt
    10321 gaccgcggtc ggcgcgctgt ccgtgccgat ggtgctggcc gccgtacgcg acatgagcgg
    10381 cgaggccgcc gcgcgcccgt acgcgcccct gctggcgctg gcgccgtacg cggtgtggac
    10441 ggcggtgtcg atggacgccg tggtggccac gctcggcgcg gcgatgacgc tggccggcgt
    10501 gcgcgccacc cggcgccacg gctggcgcgc ggcgctgtgg gcggtgctgg ccgggctgct
    10561 gctcggcgtg gccgcgctgt tctcgtacgc ggtggcctgg ctcgggctgt ccgtggtgtt
    10621 cctgaacttc gcgcggcgcc gggccgccct gaacatgttc gccgggctgg gcgtgctgct
    10681 gccggtgctc ggcgcggccc ggctcggctt cacctggacc gacgggctgg gcacggcgta
    10741 cgccgacttc gccgaacgga tcgagccgca tcgcagcgcg atgtggtggg gcctgatcag
    10801 cgtgtgcgcg ctgctgctgg cggtg
//
