LOCUS       NZ_AP023360            11263 bp    DNA     linear   CON 25-AUG-2024
DEFINITION  Catellatospora sp. IY07-71 chromosome.
ACCESSION   NZ_AP023360
VERSION     NZ_AP023360.1
KEYWORDS    RefSeq.
SOURCE      Catellatospora sp. IY07-71
  ORGANISM  Catellatospora sp. IY07-71
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Catellatospora.
REFERENCE   1
  AUTHORS   Komaki,H. and Tamura,T.
  TITLE     Whole genome shotgun sequence of Catellatospora sp. IY07-71
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8595826)
  AUTHORS   Ichikawa,N., Komaki,H., Tamura,T. and Uohara,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2020) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :https://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.4
            Genome Coverage                   :: 381x
            Sequencing Technology             :: SMRT cell 8 Pac V3
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018326265.1-RS_2024_08_25
            Annotation Date                   :: 08/25/2024 05:22:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,732
            CDSs (total)                      :: 7,655
            Genes (coding)                    :: 7,563
            CDSs (with protein)               :: 7,563
            Genes (RNA)                       :: 77
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 62
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 92
            CDSs (without protein)            :: 92
            Pseudo Genes (ambiguous residues) :: 0 of 92
            Pseudo Genes (frameshifted)       :: 20 of 92
            Pseudo Genes (incomplete)         :: 82 of 92
            Pseudo Genes (internal stop)      :: 2 of 92
            Pseudo Genes (multiple problems)  :: 12 of 92
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:09:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4992663
            Orig. end                         :: 5003926
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023360.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Annotated at DFAST https://dfast.nig.ac.jp/
FEATURES             Location/Qualifiers
     region          1..11263
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="13"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11263
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11263
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6263](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6263)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    30..43
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.57"
                     /tool="antismash"
     gene            complement(471..3110)
                     /locus_tag="CS0771_RS22245"
                     /old_locus_tag="CS0771_44540"
     CDS             complement(471..3110)
                     /EC_number="2.4.-.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020522683.1"
                     /locus_tag="CS0771_RS22245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_44540"
                     /product="transglycosylase domain-containing protein"
                     /protein_id="WP_212842796.1"
                     /transl_table=11
                     /translation="MTSPPTPTSGRSPVPPDDNAGTRGETAGQSGYTNPDRTISASPSP
                     PPGRVAGRAAVPTVAGRAPAATCRPTPGGSGRAAVRPAGTAPEGRPARTRLSEADSKGK
                     RRKRWGRSILLASVAMIVMLAGGGLIAGAYFYDSVPEPADFSENENTFVYSSDGEQIAK
                     LGGENRQIVAMPTLSDEVKAALIAGEDKNFFQHSGIDVWGIARAAWNNLTGGETQGAST
                     ITQQYARNAAKDLEVSYARKLREAVMARRLEEEHSKDEILGFYVNTVWFGRGSSGVGAA
                     ARAYFGKPADKLTVEEAAVLGAVLKQPEPNEADGSKGFDPHFNPDAARIRWNYVLDNLV
                     EMGRIDAQQRAAMVYPDKALRKYSAKSGETGVQGTGTGFVIQKYVDREMTAWGITDWRN
                     KGYRITTTINAKAQKALEAQLFRTFEWKQSCTGKGDQKQCTNDVEDAIDVKGTKINGYP
                     KNVIAAGVAIDPKTGRVLAYYGGADGTGIDYAGKINEGTTWEDGGHPPASSFKVYTLAA
                     AIDAGISLKSTWDPTPITATGKNKNCDKYKLCPYEVENAGRDPGKLKCKRKCTLKDVTR
                     MSLNVPFFKIAKKIGPDKVVKMAHAAGVNTMWALSDGKARDLTDPATDISRASFDYQVG
                     FGQYPITVLDHASGMATFANHGIYYKPHFVIKVEKKDEKTGKYKLVPQAGEVIQAERRI
                     RAEVADEVTGVLKTMPGYYYHPLLGRQAAAKTGTWESKTKENAHSHVWTVGYTPQIASA
                     IWVGNVKNASDPIYRPAKLGGGNITSVGLPADIWQAFMNAAHTGMKLLPEPLANGTGGK
                     LGESEGVGDGVDPPKKDDDDEDCDDDDEKKCKKKPAPGGSPVPSPPPGGPGPGPIVLPT
                     PLQSLLGG"
     gene            complement(3463..4704)
                     /locus_tag="CS0771_RS22250"
                     /old_locus_tag="CS0771_44550"
     CDS             complement(3463..4704)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="CS0771_RS22250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_44550"
                     /product="MFS transporter"
                     /protein_id="WP_212842797.1"
                     /transl_table=11
                     /translation="MRQHIEAAGVNGRRLFHRDFSYWYLARSISVAGTAASAVALPLLA
                     YRTSGSPTLTAAVLGLEALPYLLFGLFAGAAADRLRRKHMMITADVCCALLLATVPVAA
                     LFDALTTWHLLIVAFGVGCGFCWFDAAAWGAFVSIVGKPGITRANSLIWSTEIVLEIAA
                     PATAGLLAAITDPTLVLAVDAATYLVSAALLAQIRTGLDPGPAVARRLRAEIAEGVRHL
                     WRTPVLRTLTAAGFGLNVAAGGALGLLVVHADRALDIGPEDQRLGLLYAAAAVGSLVAA
                     VILPQASRWAGQGTVSITGLIIFGAALIGLAGTSAFTSALTGWAIWAVARLTVNANGIT
                     VRQLLTPDALQGRVNTTGRMLAWGGTPFGAVIGGLAADAYGVRVTYLMLAVPVVLSLAL
                     VIASPVRGLRIAVD"
     gene            complement(4713..4943)
                     /locus_tag="CS0771_RS22255"
                     /old_locus_tag="CS0771_44560"
     CDS             complement(4713..4943)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CS0771_RS22255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CS0771_44560"
                     /product="hypothetical protein"
                     /protein_id="WP_212842798.1"
                     /transl_table=11
                     /translation="MARLSPPGGGGGTLCFHPGDDNKPTARHSQPGGGGAACFHPSDDG
                     SASMTHLADDLAADLHLALASIDYRQLAVLA"
     gene            complement(5001..6263)
                     /locus_tag="CS0771_RS22260"
                     /old_locus_tag="CS0771_44570"
     CDS             complement(5001..6263)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.5"
                     /locus_tag="CS0771_RS22260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_44570"
                     /product="YcaO-like family protein"
                     /protein_id="WP_212842799.1"
                     /sec_met_domain="YcaO (E-value: 9.5e-32, bitscore: 109.8,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTSGKAAVPFRSVPAESALATASAEISRLGLTARAEVLGPTASP
                     IMRVTLFRDGGSVAVGAGKGAGPQGAASAHFEALERYLMSAQENRRWTADATRLLPASA
                     VAGQSALERDLVIQRWAAEFPNSVAACAPYGGVRYPTFLADPRYYRWPVAGDDVRPYRS
                     LLRYSSSLGTAAGVDLAEAVYHGLCELIEHDGLGQALLRWYIAGVPDVDLVPVEDLPDE
                     LRALHAEAVRAAGASVHLLDVTTDLDVPVYLAASPAASGEPTRLGAGASLWATDAASRA
                     LGELIQVCALSSTAGGSPAVDRLATWQALRRCALMPLDELLSGPVRAVPLRADMAGDGS
                     PDWGLEQVRRALARHGIDYHVCEVAPAGSSIAVATTIVPGLERFSLVRHGVPVIPTGRG
                     WALWPSPGPAMITRPSPVTTK"
     gene            complement(6485..6715)
                     /locus_tag="CS0771_RS22265"
                     /old_locus_tag="CS0771_44580"
     CDS             complement(6485..6715)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CS0771_RS22265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CS0771_44580"
                     /product="hypothetical protein"
                     /protein_id="WP_212842800.1"
                     /transl_table=11
                     /translation="MSIFADEFTATRMMLISVVSSDEMCCDTLTLDQPLFLRPGDRMSF
                     HGVEVVVDRSSGRRERLTGSSGRALQRSRLR"
     gene            complement(6712..7032)
                     /locus_tag="CS0771_RS22270"
                     /old_locus_tag="CS0771_44590"
     CDS             complement(6712..7032)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CS0771_RS22270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CS0771_44590"
                     /product="hypothetical protein"
                     /protein_id="WP_212842801.1"
                     /transl_table=11
                     /translation="MALTQHASRPIVVDGVEYRWLVRQRPSSSQGIGAPLTFAVELPGV
                     HGAVLVVTTDAARPDNWIGSPSAVIRPAQVAACVRAALRGGWRPAQPGPAFLADAALME
                     AS"
     gene            7085..7594
                     /locus_tag="CS0771_RS22275"
                     /old_locus_tag="CS0771_44600"
     CDS             7085..7594
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CS0771_RS22275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CS0771_44600"
                     /product="hypothetical protein"
                     /protein_id="WP_212842802.1"
                     /transl_table=11
                     /translation="MEATFGRAQPLEAPAPVAMCSEGKRVLGIGGAAVGGHHFKLISIH
                     PHNTLPDVLRGVSATVAPDETGCGRFGAWVYAICSNPIGQHVVSADSVESSINNGVSVA
                     CPAGTKVHRVGAFINLGFEPWRHLHLNRVGLFGPGALSGVDVAAHEDQTGYADDWHVHA
                     YAICAP"
     misc_feature    complement(7086..7100)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.09"
                     /tool="antismash"
     gene            complement(7643..8377)
                     /locus_tag="CS0771_RS22280"
                     /old_locus_tag="CS0771_44610"
     CDS             complement(7643..8377)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="CS0771_RS22280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="CS0771_44610"
                     /product="hypothetical protein"
                     /protein_id="WP_212842803.1"
                     /transl_table=11
                     /translation="MSRAGHPSAVDVAAQLDYYLVYANARARDRALPPEGIVLEEFVLR
                     PDGTTSALDSAGWTAAGGTWWSAVTFSRGLRTDARLRARVTPVGRAGAQAAYQAACGAA
                     LPPEPELRRHFLDRLELPASAPAHLVPAQATPERCVYRVLLAGELPEHGRAALRSGWRM
                     QPFDRGDDTAHRIAGRTRRTLDGQTVTWTLRQLGDEATWAVDLSTDRSDNPATPALAPL
                     LLRLRTEARGQGLIPVAVERMP"
     gene            complement(8530..10140)
                     /locus_tag="CS0771_RS22285"
                     /old_locus_tag="CS0771_44620"
     CDS             complement(8530..10140)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014444572.1"
                     /locus_tag="CS0771_RS22285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="CS0771_44620"
                     /product="RICIN domain-containing protein"
                     /protein_id="WP_212842804.1"
                     /transl_table=11
                     /translation="MLPERRPPRPRRRALLAVLATAALAATAFLVSSPAAHAATVDTGA
                     TYVFVNRHSGKAMDLYGWSTADGAPINQYTRNDLAVQQWRFTDVGSGYYQIRSVHSGKV
                     LELPNANDGVQLVQNTAVSGNTRQHFGLADSAGGYVRFLNRHSGKALDLWGWSTADGAM
                     ISQYQDLDGANQQWQLVKLGSGGGTGCGSGSYNAEAVLSGSTWTARNGGSTVYTGTDLR
                     AAVQAAVNSLSAGRTSKQRVVVRGSGSMSANARISLPSYTTLDVCGTINVTGTGSGDQA
                     PVYSRGTTQVEVQHLNLTGTPLYGIFMRNVTDVVLGQIDMRLSAGLGVRIDNRGDTSQW
                     TRNVRIDNVYVSGASSHAVETYGVDGLTVGTVTARNVGESGLLLNQTINATVGTVDAEN
                     AGAGTGYAAFRMANRNGRVGSSYGTNIRVGTVRARGGGRGIFCVSESGGAAIDRVDIAN
                     TGNNAILIENCYNVNIAANGGTISGGGEVRLAERTEFAGNRDITLRNFTLVNSRVVENP
                     CADNLSISITLSNSTIVRC"
     misc_feature    10214..10228
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.31"
                     /tool="antismash"
     misc_feature    complement(10216..10227)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: strong, score: 19.78"
                     /tool="antismash"
ORIGIN
        1 cctggtcgat cgcggcggtc gcgccgaggt cgacgcggat ccactgcggg tcgctgaact
       61 ggctggacca gcgcgtgccg gggtcgccgt cgacggcggc ggcggccggc gtgcccgcgc
      121 cctcgatcga cgacgcggtg accggcttgc cctgcgagat cagggggccg gcggcctgcg
      181 ccggggtgtt ggccaccagg gactgtgcga gcagtaccag agcggcggtg acggacgccg
      241 ccagcgcggc ccggcggaac cgggcccgtc tggcgacggg tgggatggac atgggctgct
      301 cctgtcgtgg tgcgggacgg gacaggacgc gccgcgtggg ggacggccac ggtggacgcg
      361 tcgtgtttgg agagcgctct ccaaagcagc ttcatagagt cgggccgatt agtcaacccg
      421 tgcccgaccg gcccggacgg cgcaccgccg tccgggccgc acgcatcagg tcagccgccg
      481 agcagggact gcagcggtgt cggcagcacg atgggaccgg gaccgggacc gcccggcggc
      541 ggtgacggca cggggctgcc gccgggcgcc ggcttcttct tgcacttctt ctcgtcgtcg
      601 tcgtcgcagt cctcgtcgtc gtcgtccttc ttcggcgggt cgacgccgtc gccgaccccc
      661 tcggactcgc cgagcttgcc gccggtgccg ttggccagcg gctcgggcag cagcttcatg
      721 ccggtgtggg cggcgttcat gaaggcctgc cagatgtcgg cgggcaggcc gacgctggtg
      781 atgttgccgc cgcccagctt ggcgggccgg tagatggggt cggaggcgtt cttgacgttg
      841 ccgacccaga tcgccgacgc gatctgcggg gtgtagccga ccgtccacac gtgggagtgg
      901 gcgttctcct tggtcttgct ctcccaggtg ccggtcttcg cggcggcctg gcggcccagc
      961 agcgggtggt agtagtagcc gggcatcgtc ttgagcaccc cggtcacctc gtcggccacc
     1021 tcggcgcgga tgcggcgctc ggcctggatg acctccccgg cctgcgggac cagcttgtac
     1081 ttgccggtct tctcgtcctt cttctcgacc ttgatcacga agtgcggttt gtagtagatg
     1141 ccgtggttgg cgaaggtcgc catgcccgag gcgtggtcca gcacggtgat cgggtactgc
     1201 ccgaagccga cctggtagtc gaacgaggcg cggctgatgt cggtggccgg gtcggtgagg
     1261 tcgcgcgcct tgccgtcgct gagcgcccac atggtgttga cgccggccgc gtgcgccatc
     1321 ttgacgacct tgtccgggcc gatcttcttg gcgatcttga agaagggcac gttgagcgac
     1381 atccgggtga cgtccttcag cgtgcacttg cgcttgcact tgagcttgcc cgggtcgcgg
     1441 ccggcgttct ccacctcgta cgggcacagc ttgtacttgt cgcagttctt gttcttgccg
     1501 gtggcggtga tcggcgtcgg gtcccaggtc gacttcagcg agatgcccgc gtcgatcgcg
     1561 gcggccagcg tgtacacctt gaacgacgac gcgggcggat ggccgccgtc ctcccaggtg
     1621 gtgccctcgt tgatcttccc ggcgtagtcg atgccggtgc cgtcggcgcc gccgtagtag
     1681 gccagcaccc ggcccgtctt cgggtcgatg gcgaccccgg ccgcgatcac gttcttcgga
     1741 tacccgttga tcttcgtgcc cttgacgtcg atcgcgtctt ccacgtcgtt ggtgcactgc
     1801 ttctggtcgc ccttgccggt gcacgactgc ttccactcga aggtgcggaa cagctgcgcc
     1861 tccagcgcct tctgcgcctt cgcgttgatc gtcgtggtga tccggtagcc cttgttgcgc
     1921 cagtcggtga tgccccaggc ggtcatctcc cggtccacgt acttctggat cacgaagccg
     1981 gtgcccgtgc cctgcacccc ggtctcaccc gacttcgcgg agtacttgcg cagcgccttg
     2041 tcgggataga ccatcgccgc ccgctgctgg gcgtcgatcc ggcccatctc gaccaggttg
     2101 tccagcacat agttccaccg gatgcgggcc gcgtccgggt tgaagtgcgg gtcgaagccc
     2161 ttgctgccgt cggcctcgtt cggctccggc tgcttgagca ccgcgccgag caccgcggcc
     2221 tcctcgaccg tcagcttgtc ggccggcttg ccgaagtacg ccctggccgc cgcgcccacg
     2281 ccgctcgatc cgcggccgaa ccacaccgtg ttcacgtaga agccgaggat ctcgtccttg
     2341 ctgtgctcct cctccaggcg gcgcgccatc accgcctcgc gcagcttgcg ggcgtagctg
     2401 acctccaggt ccttcgcggc gttgcgggcg tactgctggg tgatcgtcga ggcgccctgc
     2461 gtctcgccgc cggtcaggtt gttccacgcg gcgcgcgcga tgccccacac gtcgatgccg
     2521 ctgtgctgga agaagttctt gtcctcgccc gcgatcagcg ccgccttcac ctcgtcggac
     2581 agcgtcggca tggcgacgat ctgccggttc tcgccgccga gcttggcgat ctgctcgccg
     2641 tcggaggagt agacgaaggt gttctcgttc tcgctgaagt ccgcgggctc gggcaccgag
     2701 tcgtagaagt aggcgcccgc gatcaggccg ccgcccgcga gcatcacgat catcgccacc
     2761 gaggccagca ggatgctgcg tccccaccgc ttgcggcgct tgcccttgct gtcggcctcg
     2821 ctgagccggg tacgggccgg ccgcccctcc ggggccgtcc cggcgggacg tacggcagcc
     2881 cgcccggagc cgccgggcgt cgggcggcag gttgcggcgg gcgctcgccc cgcgacggtc
     2941 ggcacggcgg cgcggcccgc gacccggccg ggcggcgggc tcggcgacgc ggagatggtg
     3001 cggtccgggt tggtgtaccc actctgacct gcggtttcgc cgcgggtgcc ggcattgtcg
     3061 tcgggtggga cgggggagcg gcccgaggtg ggcgtcgggg gcgaagtcat tggtcacacc
     3121 cttcgagtcg tcgcgtggcg gagtgctcgt cggcccggcc tgaaggagcg tcgctcccac
     3181 cggattacat ccgggttgtc cggtcctgca cccttctaac gacgcacccc cacgggtcgc
     3241 tccacccgcc gcgtcaggtc acacccgaca gctcacccga cctggcgacg acgctgaccg
     3301 aggtcgctgg aacgagcgca ctggtctgcg gttcggggtt cgagtccccg gcagcgcacc
     3361 gcgaaagccc cgtctcatca tccgtgcgcg tcacgcagtc tcgcccagct gcccctcaag
     3421 cggtcacacg gtgaagaggt caccggccgc ggcagacctg agtcaatcga ccgcgatgcg
     3481 caggccacgc accggcgagg cgatgacgag ggcgaggctg agcacgacgg gcacagccag
     3541 catcaggtac gtgacccgga ccccgtaggc gtcggcggcc aggccgccga tcacggcgcc
     3601 gaacggagtg ccgccccagg ccagcatgcg cccggtggtg ttgacgcggc cctggagcgc
     3661 atcgggtgtg agcagctgtc gcacagtgat gccgttggcg ttcacggtca ggcgcgccac
     3721 ggcccagatc gcccacccgg tcaacgccga cgtgaaggcc gacgtgccgg ccaatccgat
     3781 gagggccgcg ccgaagatga tgagcccggt gatggacacc gttccctggc cggcccaccg
     3841 gctggcttgg ggcaggatga cggcggcgac cagcgatccg accgcggcgg cagcgtagag
     3901 caggcccagc cgttggtctt cgggcccgat gtcgagagcc cggtcggcgt gtacgacgag
     3961 cagacccagc gcgccgccgg cggccacgtt caggccgaag cccgcagcgg tcagcgtacg
     4021 caggaccggt gttcgccaga ggtggcgcac cccttcggcg atctcggccc gcagccggcg
     4081 ggccaccgcc ggccctgggt ccaacccggt tcgtatctgg gcgagcagcg ccgcggacac
     4141 cagataggtg gcagcgtcga cggccagtac cagagtgggg tcggtgatcg cggccagcag
     4201 gccggcagtg gcgggcgcgg cgatctccag cacgatctcg gtggaccaga tcaggctgtt
     4261 cgcccgggtg atccccggct tgccgacgat gctgacaaag gcaccccagg ctgcggcgtc
     4321 gaaccagcag aagccgcagc ccacgccgaa cgccacgatg agcaggtgcc aggtggtcag
     4381 cgcatcgaac agcgcggcga ccggtacggt ggcgagcagg agagcgcagc atacgtcagc
     4441 ggtgatcatc atgtgcttgc gccgcagacg gtccgcggcg gcaccggcga agagcccgaa
     4501 cagcaggtac ggcagggctt cgaggccgag caccgccgcg gtcagcgtgg gggagccgct
     4561 cgtccggtag gccagcagcg gcagggcgac ggcgctggca gcggtccccg cgaccgagat
     4621 cgatcgggcg aggtaccagt aggagaagtc acggtggaac agccggcgtc cgttgacgcc
     4681 ggctgcctcg atgtgctgcc tcaccgcctg cttcaggcga gcacggcgag ttgccggtag
     4741 tcgatgctgg ccagcgcgag gtgcaggtcg gccgccagat cgtcggcgag gtgggtcatc
     4801 gacgcactgc cgtcgtcact cgggtggaag caagcggcgc cgccgccacc gggctgggag
     4861 tggcgagccg tcggcttgtt gtcgtccccg gggtggaagc acagggtgcc gccaccaccg
     4921 ccaggcgggg agagacgagc catcggctct ttacccgcgc caccgggacg gaatggaacg
     4981 tcgctagtag acatgttccc tcatttcgtg gtaactggac tcggtcgggt gatcatcgcc
     5041 gggcctgggg acggccacag ggcccagccc cgcccagtcg ggatgacggg caccccgtgc
     5101 cgcaccaggc tgaagcgctc cagtcctggg acgatcgttg tggctaccgc gatcgacgag
     5161 ccggccggcg cgacctcgca cacgtggtag tcgatgccgt gacgggccag agcccggcgg
     5221 acctgctcca gcccccaatc cgggctgccg tcaccggcca tgtccgcgcg tagcggcacc
     5281 gcccgcaccg ggccggacag cagttcgtcg agtggcatca gggcacatcg tcgtagcgcc
     5341 tgccaggtcg ccagacggtc gaccgcaggc gagccgccgg cggtcgagga gagcgcgcag
     5401 acctggatca gctcgccgag ggcgcgcgac gcggcgtcgg tggcccagag cgacgcgcct
     5461 gccccgagcc gggtcggctc gccgctggcc gctgggctgg ccgccaggta caccggcaca
     5521 tccaggtcgg tggtgacgtc gagcaggtgc accgaggcgc cggccgcccg cacggcctcc
     5581 gcgtgcagcg cacgcaactc gtccggcaga tcctcgacgg gcacgaggtc gacgtccggc
     5641 acgcccgcga tgtaccagcg cagcagcgcc tgcccgaggc cgtcgtgttc gatcagctcg
     5701 cagaggccgt ggtagacggc ctctgccagg tcgacacctg ccgcagtgcc caggctggac
     5761 gagtaccgca gcagactgcg gtacggtcgg acgtcgtcac cggcgaccgg ccaccggtag
     5821 tagcgagggt cggcgaggaa cgtgggataa cggactccgc cgtaaggggc acacgccgcg
     5881 acggagttcg gaaattccgc tgcccaccgc tgtatgacga ggtcccgctc cagggcggac
     5941 tgcccggcta cggcgctcgc aggcagcagc ctggtggcgt ctgcggtcca tcggcggttc
     6001 tcctgggcgg acatgagata gcgttccagg gcctcgaagt gcgcgctcgc cgcgccttgg
     6061 gggcccgcgc cttttcccgc gccgacggcg actgatcctc cgtcccggaa cagcgtgacg
     6121 cgcatgatcg gcgatgcggt tgggccgagg acctccgccc gcgccgtgag gccgagccgg
     6181 ctgatctcgg ccgaggctgt cgcgagcgcg ctctcggccg gcactgatcg gaagggcact
     6241 gcagccttcc cggaggtgtt caccggccca gactgttcca gaggcctgcg ttgatgtcaa
     6301 cggctggtag cggatccgaa gccgcacgac gtaccgcggc ccgagccgga cccggccgcc
     6361 gaatctgcgg cttcggcggc cgacagcccg ttctggtgac cacggctagt cccgggacat
     6421 cgccatcgga ttccgaggag tggcgcgaat ccgaggtgac gaggaggacg gcgttgcgac
     6481 ggcgctagcg cagtcgcgaa cgctggagcg cgcgtccgct acttcccgtc agccgctccc
     6541 ggcgtccgga cgatcggtcg acgacgacct ccacgccgtg gaaactcatg cggtcgccgg
     6601 ggcgaaggaa caagggctgg tccagagtca gggtatcgca gcacatctcg tcggaggaaa
     6661 ccacgctgat caacatcatg cgtgtggccg tgaactcgtc agcaaagatg ctcatgacgc
     6721 ttccatcagc gccgcgtcag cgaggaatgc aggccctggc tgcgccggcc gccagccgcc
     6781 gcgcagtgcc gccctgacgc aggcggcgac ctgcgcagga cggatcacgg ctgatggaga
     6841 tccgatccag ttgtcgggtc gggcagcatc ggtcgtgacg accagcaccg cgccgtgcac
     6901 gccggggagt tcgacggcga aggtgagcgg cgcgcctatg ccctggctgc tggagggccg
     6961 ctgccgtacg agccagcggt actcgacacc gtccaccacg atgggacggc ttgcgtgttg
     7021 cgtcagcgcc acgaccactc cgatctcagt ctctccgtgc cagtgtcgct gcctgcagtc
     7081 cggggtggaa gcgactttcg gccgcgctca gccgctggaa gcgcccgcgc cggtggcgat
     7141 gtgctcagag ggcaagcggg tcctcggcat cggcggcgcc gcggtaggtg gacaccattt
     7201 caagctgatc tccatccacc cccacaacac gctccccgac gtcctgcggg gcgtctcggc
     7261 gacggtggcg cccgacgaga ccggctgcgg ccgcttcggt gcctgggtgt acgcgatctg
     7321 cagcaacccg atcgggcagc acgtcgtctc ggccgacagc gtcgaatcgt cgatcaacaa
     7381 cggtgtgagc gtggcgtgcc cggcggggac gaaggtgcac cgggtcggcg cgttcatcaa
     7441 cctgggcttc gagccgtggc ggcatctgca cctcaaccgg gtcggcctgt tcgggcccgg
     7501 cgcgctgtcc ggcgtcgacg tggccgcgca cgaggaccag accggctacg ccgacgactg
     7561 gcacgtgcac gcgtacgcga tctgcgcgcc ctgagaccgg accgccgccg agccctggca
     7621 cggtccgggc tggtcccgcc gtctagggca tacgctcgac ggcgaccggg atcaggccct
     7681 ggccgcgggc ctcggtgcgc aggcggagca gcaacggggc cagggcgggc gtcgccgggt
     7741 tgtccgagcg gtcggtggac aggtcgacgg cccaggtcgc ctcgtcgccg agctgacgga
     7801 gcgtccaggt caccgtctgc ccgtccaggg tgcggcgggt gcgtcccgct atgcgatgtg
     7861 ctgtgtcgtc cccgcggtcg aacggctgca tccgccagcc gctgcgcagc gccgcacgcc
     7921 cgtgctcggg cagctcgccg gccagcagca cccggtagac gcaccgctcg ggggtggcct
     7981 gcgcgggcac caggtgggcg ggcgcggagg cgggcagctc cagccggtcg aggaagtggc
     8041 ggcgcagctc cggttccggc ggcagcgccg caccgcacgc cgcctggtac gccgcctgtg
     8101 cgcccgcccg gccgacgggt gtcacccggg cgcgcagccg ggcgtcggtg cgcaggcctc
     8161 gactgaacgt gacggcgctc caccaggtgc cgccggcggc cgtccaaccc gcactgtcca
     8221 gcgcggacgt ggtgccgtcg gggcgcagca cgaactcttc gaggacgatg ccctcgggcg
     8281 ggagagcgcg atcccgggcg cgggcgttgg cgtacacgag gtagtagtcg agctgtgcgg
     8341 cgacgtcgac ggcggaagga tgtccagcgc ggctcacgcc cttgatgatg tcgtcgaggg
     8401 gtccggcgac gcagctgaca cgccgtgagc ggagtgtcgg atatcgatgc ccggcgtcgg
     8461 cgatggccta tgtgcaccct cggtgacggg ggccgccgga cgtggcggcc cccgtgctgc
     8521 caggcgttct cagcacctga cgatcgtcga gttgctgagg gtgatgctga tggacaggtt
     8581 gtcggcgcag gggttctcca ccactcggct gttcaccagg gtgaagttgc gcagggtgat
     8641 gtcgcggttg ccggcgaact cggtgcgctc ggcgagccgg acctcgccgc cgccgctgat
     8701 cgtgccgccg ttggcggcga tgttcacgtt gtagcagttc tcgatcagga tcgcgttgtt
     8761 gccggtgttg gcgatgtcca cccggtcgat ggcggcgccg ccgctctcgg agacgcagaa
     8821 gatgccgcgg ccgccgcccc gggcgcgcac ggtgccgacc cggatgttgg tgccgtagct
     8881 ggagccgacg cggccgttgc ggttggccat ccggaacgcc gcgtagcccg tgcccgcccc
     8941 ggcgttctcg gcgtcgacgg tgccgaccgt ggcgttgatc gtctggttga gcagcaggcc
     9001 ggactcgccg acgttgcggg cggtcacggt gccgacggtg aggccgtcga cgccgtaggt
     9061 ctccacggcg tgcgaactcg cgccggacac gtacacgttg tcgatgcgca cgttgcgggt
     9121 ccactggctg gtgtcgccgc ggttgtcgat gcgcacgccg agcccggcgg acagccgcat
     9181 gtcgatctgg ccgagcacga cgtcggtgac gttgcgcatg aagatgccgt acagcggcgt
     9241 gccggtgagg ttgaggtgct ggacctcgac ctgggtggtg ccgcgggagt agacgggtgc
     9301 ctggtcgccg gagccggtcc cggtgacgtt gatggtgccg cacacgtcga gggtggtgta
     9361 gctgggcagc gagatgcggg cgttggcgct catcgagccg gagccgcgta ccaccacgcg
     9421 ctgcttgctg gtgcgcccgg cggagaggct gttgaccgcc gcctgcacgg ccgcccgcag
     9481 gtcggtgccg gtgtagacgg tgctgccgcc gttgcgggca gtccacgtgg agccgctgag
     9541 cacggcctcg gcgttgtagg agccgctgcc gcagcccgtg ccgccgccgg acccgagctt
     9601 gaccagctgc cactgctggt tggcgccgtc gaggtcctgg tactgggaga tcatcgcgcc
     9661 gtcggcggtg gaccagcccc acaggtcgag cgccttaccg ctgtgccggt tgaggaaccg
     9721 gacgtagccg ccggccgagt cggccaggcc gaagtgctgg cgggtgttgc cgctgacggc
     9781 ggtgttctgg acgagctgga cgccgtcgtt ggcgttgggc agttcgagca ccttgccgct
     9841 gtgcacggac cggatctggt agtagccgct gccgacgtcg gtgaagcgcc actgctgcac
     9901 cgcgaggtcg ttgcgggtgt actggttgat cggagcgccg tcggcggtgg accagccgta
     9961 caggtccatc gccttgccgc tgtgccggtt gacgaacacg taggtcgcgc cggtgtcgac
    10021 ggtcgccgcg tgcgccgccg ggctcgacac gagaaaggcg gtggcggcga gcgccgctgt
    10081 ggcgaggacg gcgagcaggg cacgccgtcg ggggcgtggt ggcctgcgct caggcagcat
    10141 gcgtttctcc tccgttgaga cccgtgaagg cgccgcccgg aggcgaagct gccggcttcg
    10201 ccgacgccag tgatggaaag cgttttccgg attggaggct acggtggaga gctatggctg
    10261 tcaatgccaa ccttgtgtgc atcaccccgg atgtcgtata cggccatcgc tcaggcgccg
    10321 gttctcgctg caccggcaaa ggcggcgacg tgcacctgcg ggggatttcg tagatacctg
    10381 gcggctccta ggatcacggg gtggagcacc tttcggagga ggcaccgccg gacccccacg
    10441 ttctgttcgc ccgcgggttg ccactcatcg acgacccagc cacactggac gacggtctgc
    10501 ggctgctgcg gtcggcggtc ggccgaacgc cgcacaacga ccgggcgcgg cctttccggt
    10561 tgctcaacct cggcgtcgcg gtcgacaacc gttggcagcg tgacggcgat ccggccgacc
    10621 tcgacgaagc catcgacctg taccggcagg ccgctcccga tgccggcgta cgccgtgctt
    10681 gcctgaccaa cctctgctac gcgctgcgga tgcgataccg cctgaccggc gcgagggcgg
    10741 acctggatgc tgcagtcgag gcgggcgcgg actgcctggc cgcagtgcct ggcgacgacg
    10801 atcgccgggc cgaccggctc gaacaggcgg cgcatgcgcg cagggagcgc tacgaagtca
    10861 cccgcgacct gggtgacctc cgaatcgccc tggacctgta ccgggaagcc gtcgcgctga
    10921 ccacctcacc cggcggcggt gatccgactg gccgtgcact cgtgcacctg cgcaactacc
    10981 atctggtctc gcgtgaacac cacacggcca cgggggatga gcgctcggcg gctacggcga
    11041 tcacgacggc gctgcggctg gccggggatc cgctcggtgc cggagcggtg cagtgggccg
    11101 cgcgccggct gatagacgga gctgagccgg acgggcccag ccgggccgcg gcggcgctgc
    11161 gtcgcgcggc cgcgctcgcc gagggcaccg atgcgactac gctacgactc gatctggtca
    11221 ccgcactgcg gcggcacgcc gaccagaccc gtcggcccga aga
//
