LOCUS       NZ_AP023358            14858 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Micromonospora endophytica strain NBRC 109090 chromosome, complete
            genome.
ACCESSION   NZ_AP023358
VERSION     NZ_AP023358.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora endophytica
  ORGANISM  Micromonospora endophytica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Komaki,H. and Tamura,T.
  TITLE     Whole genome shotgun sequence of Jishengella endophytica NBRC 109090
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6586761)
  AUTHORS   Ichikawa,N., Komaki,H., Tamura,T. and Uohara,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2020) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :https://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.4
            Genome Coverage                   :: 293x
            Sequencing Technology             :: SMRT cell 8 Pac V3
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018326245.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 14:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,248
            CDSs (total)                      :: 6,184
            Genes (coding)                    :: 5,715
            CDSs (with protein)               :: 5,715
            Genes (RNA)                       :: 64
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 469
            CDSs (without protein)            :: 469
            Pseudo Genes (ambiguous residues) :: 0 of 469
            Pseudo Genes (frameshifted)       :: 323 of 469
            Pseudo Genes (incomplete)         :: 166 of 469
            Pseudo Genes (internal stop)      :: 12 of 469
            Pseudo Genes (multiple problems)  :: 30 of 469
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:19:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2014643
            Orig. end                         :: 2029501
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023358.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Annotated at DFAST https://dfast.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..14858
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="NAGGN"
                     /region_number="3"
                     /rules="((TIGR03104 or cds(GATase_7 and Asn_synthase)) and
                     TIGR03103 and (TIGR03106 or Peptidase_M42))"
                     /tool="antismash"
     cand_cluster    1..14858
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /kind="single"
                     /product="NAGGN"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..14858
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[5000:9858](+)"
                     /cutoff="10000"
                     /detection_rule="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /neighbourhood="5000"
                     /product="NAGGN"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9858
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((TIGR03104 or cds(GATase_7 and
                     Asn_synthase)) and TIGR03103 and (TIGR03106 or
                     Peptidase_M42))"
                     /neighbourhood="5000"
                     /product="NAGGN"
                     /protocluster_number="1"
     gene            complement(497..1906)
                     /locus_tag="Jiend_RS09320"
                     /old_locus_tag="Jiend_19300"
     CDS             complement(497..1906)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1105: amidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011904832.1"
                     /locus_tag="Jiend_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19300"
                     /product="amidase family protein"
                     /protein_id="WP_111242036.1"
                     /transl_table=11
                     /translation="MAVQDIMPTWVGATAKQIARGVRRGDVSATQVLADHLDHVVKADA
                     DLAAFRAVRGGEAVTEAEKVDEQEDLANLPLAGVPIAVKENTAVAGMPTWNGSAAVRTA
                     VAEADHEVVRRLRGAGAVILGVTRMPELGLWAVTDDDTGITRNPWDLGRTPGGSSGGAA
                     AAVAAGLVPIAHGNDGLGSIRIPAACCGLVGLKPGRGVVPRQLGAEDWFGLTEHGMLST
                     TVADAAVGFQVLAGRAQEKLVPPQRLRVGVSLRSPVRGIAPDAPNRDAVAAAGRLLAAA
                     GHDTVPADPVYPTAIGLQGIATWFAAAAADVGAAGIDRRTLQARSRRHVTFGEWATRRG
                     YVREASRVAWRERSIGFFTDHSVDLLLTPALATAPPPATSWSSRSWRANMAASIRYAPY
                     AAPWNIAGLPALVVPVGRRPDGLPLAVQLVGPPGSELLLLGVAGQFEMAAPWPRHAPGY
                     PRVGTGSPASA"
     gene            complement(1923..3065)
                     /locus_tag="Jiend_RS09325"
                     /old_locus_tag="Jiend_19310"
     CDS             complement(1923..3065)
                     /EC_number="2.5.1.48"
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0019346 - transsulfuration [Evidence IEA]"
                     /NRPS_PKS="Domain: Beta_elim_lyase (43-347). E-value:
                     3.1e-09. Score: 28.4. Matches aSDomain:
                     nrpspksdomains_Jiend_RS09325_Beta_elim_lyase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1168: O-succinylhomoserine sulfhydrylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011904831.1"
                     /locus_tag="Jiend_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19310"
                     /product="cystathionine gamma-synthase"
                     /protein_id="WP_111242035.1"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.8e-07, bitscore:
                     27.8, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 2.2e-05,
                     bitscore: 22.3, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHGFDTLAIHAGQDPEARTGAVIPPIYQTSTYAQDAVGAPRQGY
                     EYSRSGNPTRDALQECLAALEGGPVGLAFASGLAAEDALLRTVCAPGDHVVIPDDAYGG
                     TYRLFAKVAQRWGLAYTPAKISDPEAVRAAIRPGVTKVVWLETPTNPLLGIADIATLAA
                     IAHDAGALLVVDNTFASPYLQQPIALGADVVVHSTTKYIGGHSDVVGGALVAADAALGE
                     ELRYHQNAMGAVNGPFDAWLTLRGIKTLGVRMDRHCDNAERIAAYLDGHLKVAEVLYPG
                     LPSHSGHEVAAKQMRRFGGMISFRAAGGEQHAVDICNRAKLFVLAESLGGVESLIEHPG
                     RMTHASAAGSPLEVPADLVRLSVGIETVEDLLADLEQALG"
     aSDomain        complement(2025..2936)
                     /aSDomain="Beta_elim_lyase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_Jiend_RS09325_Beta_elim_lyase.1"
                     /evalue="3.10E-09"
                     /label="Jiend_RS09325_Beta_elim_lyase.1"
                     /locus_tag="Jiend_RS09325"
                     /protein_end="347"
                     /protein_start="43"
                     /score="28.4"
                     /tool="antismash"
                     /translation="GYEYSRSGNPTRDALQECLAALEGGPVGLAFASGLAAEDALLRTV
                     CAPGDHVVIPDDAYGGTYRLFAKVAQRWGLAYTPAKISDPEAVRAAIRPGVTKVVWLET
                     PTNPLLGIADIATLAAIAHDAGALLVVDNTFASPYLQQPIALGADVVVHSTTKYIGGHS
                     DVVGGALVAADAALGEELRYHQNAMGAVNGPFDAWLTLRGIKTLGVRMDRHCDNAERIA
                     AYLDGHLKVAEVLYPGLPSHSGHEVAAKQMRRFGGMISFRAAGGEQHAVDICNRAKLFV
                     LAESLGGVESLIEHPGRMTHASA"
     misc_feature    3277..3291
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.58"
                     /tool="antismash"
     misc_feature    complement(3497..3513)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.82"
                     /tool="antismash"
     gene            3501..3923
                     /locus_tag="Jiend_RS09330"
                     /old_locus_tag="Jiend_19330"
     CDS             3501..3923
                     /EC_number="2.1.1.-"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018821492.1"
                     /locus_tag="Jiend_RS09330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19330"
                     /product="HIT family protein"
                     /protein_id="WP_119663785.1"
                     /transl_table=11
                     /translation="MFCAIVAGEVPAFRVVDEADGMAFLDTRPVFKGHVLVVPRPHLVT
                     LADLPPESLPGYFGLVRRLAVAVEAGLGAGGTFVAMNNRVSQSVPHLHTHVVPRTKGDG
                     LRGFFWPRTRYADDAEATGYTDRIRAALSPPPTASI"
     gene            4097..4758
                     /gene="msrA"
                     /locus_tag="Jiend_RS09335"
                     /old_locus_tag="Jiend_19340"
                     /pseudo=""
     CDS             4097..4758
                     /GO_function="GO:0008113 - peptide-methionine (S)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_function="GO:0033744 -
                     L-methionine:thioredoxin-disulfide S-oxidoreductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020215983.1"
                     /locus_tag="Jiend_RS09335"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19340"
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MFLRRMKAEMISPDRALPGRPIAMPVADRHEVLGTPLKGPFPEGT
                     QVAVFGMGCFWGPSGCSGPCPASSPPRSVTRVATPRTRPTRRSARARPGTPRSSRWSTT
                     PPGSATRTC"
     misc_feature    4937..4954
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.45"
                     /tool="antismash"
     misc_feature    4956..4970
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.52"
                     /tool="antismash"
     gene            5001..6785
                     /locus_tag="Jiend_RS09340"
                     /old_locus_tag="Jiend_19350"
     CDS             5001..6785
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     GATase_7"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03104"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007074689.1"
                     /locus_tag="Jiend_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19350"
                     /product="N-acetylglutaminylglutamine amidotransferase"
                     /protein_id="WP_111244946.1"
                     /sec_met_domain="TIGR03104 (E-value: 3.7e-289, bitscore:
                     958.4, seeds: 10, tool: rule-based-clusters)"
                     /sec_met_domain="GATase_7 (E-value: 2e-40, bitscore: 136.1,
                     seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 9.7e-88, bitscore:
                     293.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGLAGEFRRDGSRANVAAVEAMAATMSDRGPDDSGVWSQGAIAL
                     GHRRLKIIDLSAASGQPIVDSAAGLTGVFNGCIYNYRELRAELAAKGHRFFSSGDSEVV
                     IKAYAEWGLDFVDHLVGMFAVAISERDTGRLVLARDRLGIKPLYLAESPGVVRFASTLP
                     ALLAGGGVDTTIDPVALAHYLSFHSIVPPPRTILRGVSKLPPATVRVYEADGRSHERVY
                     WNPPFVRHAEHADWSEKDWQEALLESLTTAVRRRMVADVPVGVLLSGGLDSSLVVALLA
                     GEGQRGLSTFSIGFDAVGGREGDEFRYSDVVAKTFDTDHHQIRVAAGDLVPPLEAAVAA
                     MSEPMVSHDCVAFYLLSREVSRHVKVVQSGQGADEILGGYHWYPPLQGVDREQAVETYA
                     WAFFDRDAAGLAQVLNPDWLAEGDPAREFVAAHLARPGAQTAVDAGLRIDTQIMLTDDP
                     VKRVDNMTMAHGLEARVPFLDHEFVELAAACPPELKLAQGGKGVLKEIGRRVLPHEVID
                     RPKGYFPVPGLTHLEGKLLDRVRDALHAPEAQRRGLFRTDYVNALLDAPNAELTPLNGN
                     KLWQLGLLEMWLQNHGID"
     gene            6788..8668
                     /gene="ngg"
                     /locus_tag="Jiend_RS09345"
                     /old_locus_tag="Jiend_19360"
     CDS             6788..8668
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="ngg"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03103"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RimK"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787512.1"
                     /locus_tag="Jiend_RS09345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19360"
                     /product="N-acetylglutaminylglutamine synthetase"
                     /protein_id="WP_111244945.1"
                     /sec_met_domain="TIGR03103 (E-value: 2.7e-236, bitscore:
                     783.8, seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="RimK (E-value: 3.4e-05, bitscore: 22.0,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTLATGVARTDRGRGAGRRYERVGPGGDPIAAGGTDADTEGSP
                     GDEGVVLDCGWGRLVFGQTFSDQAAVADVLRSEAAGARDICIYLRDPHVLVSRLPDELF
                     IDPSLTYRLPLGSARRQASGTSEEAGTADTPPAADGRPELPGVRIRRLRDAADADAVNR
                     IYAANGMVTAPVDVLVENAATDRFLHLVAEATTGEIVGTITGVDHVAVFDDPDNGASLW
                     CLTVDFNQAPPGTGQALITELVARLVARGRAYVDLSVLAENAGAIRLYERLGFYRTATL
                     CVKRKNPINERLFLPAMPEGYDQLNPYAKIVADEAMRRGIRVEVTDPQWGELRLTIGGR
                     TILTRESLSELTSAVAMSRCDDKRVTRRILAEAGLSVPRGRTATRDAADAEFLAEVGQV
                     VVKPARGEQGNGITVGVRTPEALTAAVELAARFCPEVLLEELCTGEDLRVIVIDHEVVA
                     AAVRRPAAITGDGVHDIAELIDRQSRRRAAATGGESRIPVDDMTREVVAEAGYELHDVL
                     PEGQVLAVRRTANLHTGGTIHDVTGELHPVIAEACVAASRALDIPVTGLDLLVPAPDQP
                     EHVFIEANERPGLANHEPQPTAERFVDLLFPGTRAPQRLWTPAGAATSGA"
     gene            8665..9858
                     /locus_tag="Jiend_RS09350"
                     /old_locus_tag="Jiend_19370"
     CDS             8665..9858
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     TIGR03106"
                     /gene_functions="biosynthetic (rule-based-clusters) NAGGN:
                     Peptidase_M42"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013731651.1"
                     /locus_tag="Jiend_RS09350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19370"
                     /product="osmoprotectant NAGGN system M42 family peptidase"
                     /protein_id="WP_111244949.1"
                     /sec_met_domain="TIGR03106 (E-value: 5.6e-146, bitscore:
                     484.2, seeds: 7, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_M42 (E-value: 1.4e-55, bitscore:
                     186.9, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVRKTIPLPIDLDYLQQVLLELLEIPSPSGRTDHVQQYVGERLS
                     ALGIPSTLTRRGALSACLPGPRETGADRAIVVHTDTIGGMVKRLKENGRLELNQIGTHS
                     ARFAEGAHVRVFTDDLERVITGQVLPLKASGHRYNEAVDLQGVGWEQVEVRIDEPVEDI
                     AGLRALGIDAGDFVAFLPNPTITPSGYVKSRHLDDKAGVAAVLTALKALVDARVTPAVT
                     AHLLITVTEEIGHGASHGLDPDVAEIVSVDAAVVAPGQQSREDAATLAMGDGVGPFDYH
                     LTRNLAAIAREHDVDLVRDVFDYYRSDVAAAVEAGAHARVALLGFGVDATHGHERTHLE
                     GLRHLTQLLCLYLQSDLVFPEWDAEPEGDLADFPSLSVQPASEEGPREGPIGIAPNP"
     misc_feature    complement(9941..9956)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 20.95"
                     /tool="antismash"
     gene            10171..11100
                     /locus_tag="Jiend_RS09355"
                     /old_locus_tag="Jiend_19380"
     CDS             10171..11100
                     /EC_number="3.1.26.11"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018729615.1"
                     /locus_tag="Jiend_RS09355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19380"
                     /product="ribonuclease Z"
                     /protein_id="WP_111244944.1"
                     /transl_table=11
                     /translation="MSMRELVVLGTASQAPTRVRNHNGYVLRWDDEVILFDPGEGSQRQ
                     LLHTGVTATDLTRICVTHFHGDHCLGLPGTIQRLSLDRVSHPVAVHFPAEGADYFARLR
                     HASSFYETAELAVTPIEADGQRIALRCGTLEARRLRHPIDTYGYRLVEPDGHRMLPEKL
                     AAYGIGGPAIGELQRVGHLDLDGRRVTRAEVSVPRPGQRFAFVMDTGLCDAVYALAEEA
                     DLLVIESTFLESEAALAAEVGHLTAGQAARVAAESGVRRLVLTHFSQRYADPRRFADEA
                     RAHFDGDLVIAEDLVTVAVPPRRVPSAQ"
     gene            11097..11606
                     /locus_tag="Jiend_RS09360"
                     /old_locus_tag="Jiend_19390"
     CDS             11097..11606
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018787509.1"
                     /locus_tag="Jiend_RS09360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19390"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_111244943.1"
                     /transl_table=11
                     /translation="MIVTLRPATADDLMLVGRLHQRSRIAAYSSFLPAAALAHPTPDAM
                     GEYWVARWTYERADHRMTVAERDGTLVGFSYLGPDDEGAPDTGLLNAIHLEPTERGRGT
                     GRELMVDALAAMRERGWRHAALWVLRDNARARRFYEGGGWQPTGLERDEMIGDAHTPQL
                     RYGRRL"
     gene            complement(11624..12547)
                     /locus_tag="Jiend_RS09365"
                     /old_locus_tag="Jiend_19400"
     CDS             complement(11624..12547)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014445926.1"
                     /locus_tag="Jiend_RS09365"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19400"
                     /product="protocatechuate dioxygenase"
                     /protein_id="WP_111244942.1"
                     /transl_table=11
                     /translation="MGYDDHEGQRVSRRRLIAGIGSVGLVGLLAACGRDGGTVTTSTGE
                     TVAPQATTASDLTSLFDGANTCTLTASTTQGPYYFDADKIRSDIREDREGALLRLAIRV
                     QDSEQCGPLANAVVEIWHCDAAGLYSGAEAQSSGANGASGGPGGTPPSGGPGGTPPGNA
                     PGGSGAPGGGDTGGDTGGDTGGGDMGDLTPTDDQRYLRGAQVTNADGIVEFTTIWPGWY
                     RGRTVHIHAMVHIDNSRVLTTQVMFDETLNSKVYAEQPYAAHTGRDTFNDNDSIYADSM
                     LLKVTEDGDGYLGVINFGVDSDQDGS"
     gene            complement(12882..14252)
                     /locus_tag="Jiend_RS09370"
                     /old_locus_tag="Jiend_19410"
     CDS             complement(12882..14252)
                     /EC_number="4.2.1.22"
                     /GO_function="GO:0004122 - cystathionine beta-synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019344 - cysteine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742048.1"
                     /locus_tag="Jiend_RS09370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19410"
                     /product="cystathionine beta-synthase"
                     /protein_id="WP_111244941.1"
                     /sec_met_domain="PALP (E-value: 6e-70, bitscore: 234.4,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQYYDNVVEMIGNTPLVRLRNVAEGIQATVLAKVEYLNPGGSVKD
                     RIALRMVEDAEAAGILRPGGTIVEPTSGNTGVGLALVAQLRGYRCVFVCPDKVSQDKQD
                     VLRAYGAEVVVCPTAVAPEDPRSYYNVSDRLAREIPGAWKPNQYANPANPRSHYETTGP
                     ELWKQTEGRITHFVTGVGTGGTISGIGMYLKEVSGGTVKIIGADPEGSVYSGGTGRPYL
                     VEGVGEDFWPETYDRDVADQIIEVSDKQSFEMTRRLAREEGLLVGGSCGMAAVAALEVA
                     RAAGPDDVIVVLLPDGGRGYLSKIFNDTWMARYGFLDNSGSEPTVAEALAGKPGGLPEL
                     VHVHPTETVRDAVDYMREYGVSQLPVLKAEPPVVTGEVAGSIAERDLLDALFTGQAQLH
                     DTIERHMGSPLPMIGGGQPVSEAVSLLEKSDAALVLIDGKPRGVLTRQDLLAHLGAR"
     gene            complement(14336..14692)
                     /locus_tag="Jiend_RS09375"
                     /old_locus_tag="Jiend_19420"
     CDS             complement(14336..14692)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007074683.1"
                     /locus_tag="Jiend_RS09375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_19420"
                     /product="YkvA family protein"
                     /protein_id="WP_111244948.1"
                     /transl_table=11
                     /translation="MAKTLKRGAAFVALGRALTAGARGGPSLGARIGALPRMIAATARG
                     QYDGGLRLAMMTAATAYIVSPIDAVPEMFLTVFGLIDDAVMVTWLAGSVLAETERFLEW
                     EARRSSVIPGHAVP"
ORIGIN
        1 cgggtggatc aacaccgcgc cggtgcgttc ggcgaacgtc tgcgccgcga ccagggactc
       61 gtccaccgtg gccccgacca gctcgacctg ggcgccgtac cccttggtgg ccgccacctt
      121 cggcagcgtc gcgttcaccg gcatgaagac ggtggcccgg gtgccgacca ggccggcggc
      181 gagcgccacc ccctgggcgt ggttgccggc gctcgccgcg accaccccac gggcccgctc
      241 ccgctccgac agccgagaga tccgcacgta cgcgccgcgc accttgtagg acccggcccg
      301 ctgaaggttc tcgcacttga gccaggccgg cccaccgagc gcggcggtga gcgggcggga
      361 aggctccagc ggggtggtgc gagtgatccc ggcgagcagc tcccgcgcgg cccgcacctc
      421 gtcgaggctg accagttccg tcatgctccg atcgtgccac ctgccccgac cggcccggcc
      481 ggcggagccg cgcagatcag gcgctggccg gtgacccggt gccgacgcgc gggtagccgg
      541 gggcatgccg gggccatggg gccgccatct cgaactgccc ggcgacgccg agcagcagca
      601 gctccgagcc gggcggaccg accagctgca cggccagcgg caacccgtcc gggcggcggc
      661 ccaccgggac caccagggcg ggcaggccgg cgatgttcca gggcgccgcg tacggggcgt
      721 accggatgct ggccgccatg ttggcgcgcc aggagcgcga cgaccagctg gtggccggcg
      781 gcggcgcggt cgccagtgcc ggggtgagca gcaggtccac cgagtggtcg gtgaagaagc
      841 cgatcgaccg ctcgcgccag gcgacccggg acgcctcccg cacgtacccg cgccgcgtcg
      901 cccactcgcc gaacgtgacg tgccgccggc tgcgggcctg cagggtgcgc cggtcgatcc
      961 cggcggcgcc cacgtccgcc gcggcggcgg cgaaccaggt ggcgatgccc tgcagcccga
     1021 tggcggtcgg gtagaccggg tcggccggca cggtgtcgtg cccagccgcg gcgagcagcc
     1081 ggccggcggc ggcaaccgcg tcccggttcg gcgcgtcggg cgcgatgccg cgcaccgggg
     1141 accgcagcga caccccgacc cgcagccgct gcggcgggac aagcttctcc tgggcgcgac
     1201 cggcgagcac ctggaacccg acagccgcgt cggcgacggt ggtgctgagc atgccgtgtt
     1261 cggtgagccc gaaccagtct tccgcgccga gctggcgggg caccacgccg cggccgggtt
     1321 tgagacccac caggccgcag caggccgccg ggatgcggat cgaaccgagc ccgtcgttgc
     1381 cgtgcgcgat cggcaccagc ccggccgcca ccgcagccgc cgcgccgccg gacgagccac
     1441 cgggggtacg gccgaggtcc cacgggttgc gggtgatgcc ggtgtcgtcg tcggtgaccg
     1501 cccagaggcc cagctcgggc atccgggtga cgccgaggat caccgcgccg gcaccgcgca
     1561 accggcggac cacctcatgg tcggcctcgg ccaccgcggt acgcaccgcg gccgagccgt
     1621 tccaggtggg catgccggcc accgctgtgt tctccttgac cgcgatcggc acgccggcca
     1681 gcggcaggtt ggccaggtcc tcctgctcgt cgaccttctc cgcctcggtg accgcctcgc
     1741 cgccgcgtac cgcccggaac gcggcgaggt cggcgtcggc cttgacgacg tggtcgaggt
     1801 ggtcggcgag cacctgggtg gccgagacat ctccccggcg tacccctcgg gcgatctgtt
     1861 tggcggtcgc cccgacccag gtcggcatga tgtcctgcac ggccaccctc cccagccagc
     1921 ggtcagccca atgcctgctc cagatcggcg agcaggtcct cgaccgtctc gatgccgaca
     1981 gacagtcgca cgagatcggc gggaacttca agcggcgagc cggcagcact cgcgtgtgtc
     2041 atccggcccg ggtgctcgat cagggattcc accccgccga gcgactcggc gagcacgaaa
     2101 agcttggccc ggttgcagat gtcgacggcg tgttgctcgc caccggcggc ccggaacgag
     2161 atcatcccgc cgaagcggcg catctgcttg gccgccacct cgtgaccgct gtgtgacggc
     2221 agccccgggt agagcacctc ggcgaccttg aggtgcccgt ccaggtaggc ggcgatccgc
     2281 tcggcgttgt cgcagtgccg gtccatccgt accccgaggg tcttgatgcc gcgcagcgtg
     2341 agccaggcgt caaacgggcc gttcaccgcg cccatcgcgt tctggtggta gcgcagctcc
     2401 tcgccgagcg cggcgtccgc cgccaccagc gccccgccga ccacgtcgga gtgcccgccg
     2461 atgtacttgg tggtggagtg caccaccacg tccgcgccga gggcgatcgg ctgttgcagg
     2521 tacggcgagg cgaacgtgtt gtccaccacc agcagcgcgc cggcgtcgtg cgcgatggcg
     2581 gcgagggtgg cgatgtcggc gatgccgagc agcgggttgg tcggcgtctc cagccagacg
     2641 accttcgtca cacccgggcg gatcgcggcc cgcacggcct ccgggtcgga gatcttcgcc
     2701 ggggtgtacg ccagccccca ccgctgcgcc accttggcga agagccggta cgtgccgccg
     2761 tacgcgtcat cggggatcac cacatgatca cccggggcgc agacggtacg cagcaacgcg
     2821 tcctcggcgg ccagcccact ggcgaaggcg agcccgaccg gcccaccctc cagcgcggcc
     2881 aggcactcct ggagcgcgtc gcgggtcggg ttgccggaac ggctgtattc atagccctgc
     2941 cggggcgcac caacggcatc ctgggcgtac gtgctggtct ggtagatcgg tgggatgacc
     3001 gcgccggtgc gggcctccgg gtcctgaccg gcgtggatcg cgagcgtgtc gaagccgtgg
     3061 ttcatttggc agacgttagt ccttccaccc accagcggct tccagtcggt cagcattgcg
     3121 gtcgtttggc accggttcgg tcagttcccg cacaagtgcg gggtcggtgt aggtcgcggc
     3181 cgtggctttc cactcacgcg gggtctgcgt caggctgcgc ctcaagcgcc gcagccccag
     3241 ctgccgaatg ctcaccccga cccaccccaa tagatcaaga tccagacaag ttcagggaaa
     3301 gtgctgcctc atcagccgcc agccggcaag acagcacttt ccccgaaact gctaccaggg
     3361 ccgaccccac cagccccgtg gccggtcact cccggttgtt cagcggaccg tcgtggcgtc
     3421 cgccgggcca cagtggcgcc tccgatcgcc tgcccgagga tgatcggtcg cgacggtacg
     3481 gtcggccggt ggcgagttgt gtgttctgcg caatcgtggc gggcgaggtg ccggcgttcc
     3541 gggtcgtcga cgaggcggac gggatggcgt tcctggacac ccgaccggtg ttcaaggggc
     3601 acgtgctggt ggtgccgcgc ccgcacctgg tgaccctggc cgacctgccg ccggagtcgc
     3661 tgcctggcta tttcgggctg gtgcggcgac tcgccgtcgc ggtcgaggcc ggtctgggcg
     3721 cgggcggcac gttcgtggcg atgaacaacc gggtgtccca gtcggtgccg cacctgcaca
     3781 cccacgtggt gccccggacc aagggcgacg gcctacgcgg cttcttctgg ccgcgtaccc
     3841 gctacgccga cgacgccgag gccaccgggt acaccgaccg catccgcgcc gccctctccc
     3901 cgccacccac cgcgtcgatc taggggaaaa cgtcgcgtgt tgatctccga tgacgacgat
     3961 agcccctaga tcgacgcgga ggtaacgggt agcgggggga cggagggggg acggggggtc
     4021 tggctggcgg tggggcgggt aaggaaacag ggtccgccgg tgttgcacgc gggaagggta
     4081 cgaaaggagt tccaccgtgt tcctccgccg catgaaggcc gagatgatct cccctgaccg
     4141 ggcgttgccc ggccgcccga tcgcgatgcc ggtcgccgac cggcacgagg tgctcgggac
     4201 cccactgaag ggcccgttcc ccgagggcac ccaggtcgcg gtcttcggga tggggtgttt
     4261 ctgggggccg agcggctgtt ctggaccctg cccggcgtct tcaccacctc ggtcggttac
     4321 gcgggtggct acaccccgaa cccgacctac gaggaggtct gctcgggcga gaccgggcac
     4381 gccgaggtcg tccaggtggt ctacgacccc accaggatca gctacgagga cctgctgaag
     4441 gtcttctggg agaaccacga cccgacccag ggcatgcgcc agggcaacga cgtgggcacc
     4501 cagtaccgct cgacgatcta cgccagcacc gacgaccagc tcgccaccgc gcaggcgtcc
     4561 cgggacgcgt tcgcgccgat cgtggcgcgg gccggcaagg gcgagatcac caccgagatc
     4621 ggccggctgg gcgactactt cctggccgag gactatcacc agcagtatct ggcacccacg
     4681 aagaacccta acggctactg caaccacggc ccgaacggac tgagctgccc ggtcggggtg
     4741 gcccgtaccg ccggctgagg ttgtcgcgcg gggtcggcgg caccggtcgt cgaccccgta
     4801 cggatgactt ctgcggctct tgtcacacag gcgcggcgcg cggaagcctc gcaagccggg
     4861 cttacccggg cggaattggt gccgcaggac ttcccatgtc gcggcaattg ctcgcggggc
     4921 gcggattcta gcaagcttgt tacacgaccg tcatggtctc aacaggcgaa tcgcaacatc
     4981 ctctggcagc atttgctggc atgtgcggac tggcagggga gttccggcgg gacgggtcac
     5041 gtgccaacgt cgccgcggtg gaggccatgg ccgccaccat gagcgaccgc gggcccgacg
     5101 acagcggcgt ctggtctcag ggggcgatcg cgctcggcca ccgccggctg aaaatcatcg
     5161 acttgtcggc cgccagcggc cagcccatcg tcgactcggc cgccggcctg accggcgtct
     5221 tcaacggctg catctacaac taccgcgagc tgcgcgccga actggcggcc aagggccacc
     5281 gcttcttctc ctccggcgac agcgaggtcg tgatcaaggc gtacgccgag tgggggctcg
     5341 acttcgtcga ccacctggtc ggcatgttcg cggtggcgat cagcgagcgg gacaccgggc
     5401 ggctggtgct ggcccgggac cggctcggca tcaagccgct ctacctcgcc gagtcgccag
     5461 gcgtggtgcg gttcgccagc accctgcccg ccctgctggc cggcgggggc gtggacacca
     5521 ctatcgatcc ggtcgcgctg gcccactacc tcagcttcca cagcatcgtg ccgccgccgc
     5581 gcaccatcct gcgcggcgtc agcaagctcc ccccggccac cgtccgggtg tacgaggccg
     5641 acgggcgcag ccacgagcgg gtctactgga acccgccgtt cgtccgccac gccgagcacg
     5701 ccgactggtc ggagaaggac tggcaggagg cgctgctgga gtcgctgacc accgccgtac
     5761 gccggcggat ggtcgcggac gtgccggtcg gtgtcctgct ctccggcggc ctggactcca
     5821 gcctggtggt cgccctgctc gccggcgagg ggcaacgcgg gctctcgacc ttctccatcg
     5881 gtttcgacgc ggtgggcggc cgggagggcg acgagttccg ctactccgac gtggtggcca
     5941 agaccttcga caccgaccac caccagatcc gggttgccgc cggtgacctg gtgccgccac
     6001 tggaagctgc cgtggcggcc atgagcgagc ccatggtcag ccacgactgc gtggcgttct
     6061 acctgctcag ccgggaggtg tcccggcacg tcaaggtggt gcagtcgggc cagggcgccg
     6121 acgagatcct gggcggctac cactggtacc cgccgctgca gggggtggac cgcgagcagg
     6181 ccgtcgagac gtacgcctgg gccttcttcg accgcgacgc cgccggtctg gcccaggtgc
     6241 tcaaccccga ctggctcgcc gagggcgacc cggcgcggga gttcgtcgcc gcgcacctgg
     6301 cccgtcccgg cgcgcagacc gccgtcgacg ccggactgcg catcgacaca cagatcatgc
     6361 tcaccgacga cccggtcaag cgggtcgaca acatgaccat ggcgcacggg ctggaggccc
     6421 gggtgccgtt cctggatcac gagttcgtgg agctggccgc cgcctgcccg cccgagctga
     6481 agctcgccca gggtggcaag ggcgtactca aggagatcgg ccgccgggtg ctgccgcacg
     6541 aggtcatcga ccggccgaag ggctacttcc cggtgccggg cctcacccac ctggagggca
     6601 agctcctcga ccgggtacgc gacgcgttgc acgcgcccga ggcccaacgc cgcggcctgt
     6661 tccgcaccga ttacgtcaac gccctgctcg acgcacccaa cgccgaactg accccgttga
     6721 acggaaacaa gctgtggcaa ctcggactcc tggaaatgtg gctccagaac cacggaatcg
     6781 actgagcgtg accggcaccc tggccaccgg tgtggcccgg accgatcgcg gtcgtggcgc
     6841 gggacgacgc tacgaacggg tcgggccggg cggtgatccg atcgccgccg gcggcaccga
     6901 cgcggacacc gaaggctcgc ccggcgacga aggtgtggtg ctcgactgcg gctggggccg
     6961 gctggtcttc gggcagacct tctccgatca ggccgccgtc gccgacgtgc tgcgctccga
     7021 ggcggccggc gcccgggaca tctgcatcta cctgcgcgat ccgcacgtgc tggtctcccg
     7081 gctgcccgac gagttgttca tcgacccgtc gctgacctac cggctgccgc tgggcagtgc
     7141 ccgccggcag gccagcggga ccagcgagga ggccggcacc gccgacactc cgcccgccgc
     7201 cgacggccgg ccggaactgc ccggggtacg catccggcgg ctgcgcgacg ccgccgacgc
     7261 ggacgcggtc aaccggatct acgccgccaa cggcatggtc accgcgccgg tcgacgtgct
     7321 tgtggagaac gccgccaccg accgtttcct gcacctggtg gcggaggcga ccaccggcga
     7381 gatcgtcggc accatcaccg gggtcgacca cgtcgcggtc ttcgacgacc cggacaacgg
     7441 cgccagtctc tggtgcctga ccgtcgactt caaccaggcc ccgcccggca ccggccaggc
     7501 gctgatcacc gagttggtgg cccgcctggt cgcgcgcggc cgggcgtacg tcgacctgtc
     7561 ggtgctggcc gagaacgccg gggcgatccg gctctacgag cggctcggtt tctaccgcac
     7621 cgccacgctc tgcgtgaagc ggaagaaccc gatcaacgag cggctgttcc tgcccgccat
     7681 gccggagggc tacgaccagc tcaacccgta cgcgaagatc gtcgccgacg aggcgatgcg
     7741 ccggggcatc cgggtggagg tgaccgaccc gcagtggggt gagctgcgac tgaccatcgg
     7801 cggccggacc atcctcaccc gggagtcgct ttccgagctg acctccgcgg tggccatgag
     7861 ccgctgcgac gacaagcggg tgacccggcg gatcctcgcc gaggccggcc tgtcggtgcc
     7921 gcgcggacgc accgccacca gggacgccgc cgacgcggag ttcctggccg aggtgggcca
     7981 ggtcgtggta aagccggccc gtggcgagca gggcaacggc atcaccgtgg gcgtacgcac
     8041 gcccgaggcg ctgaccgccg ccgtcgagtt ggccgcccgg ttctgcccgg aggtgctgct
     8101 ggaggagctg tgcaccggcg aggacctgcg ggtgatcgtg atcgaccacg aggtggtggc
     8161 cgctgcggtg cgccggcccg ccgcgatcac cggtgacggc gtgcacgaca tcgccgagct
     8221 gatcgaccgg cagagccgcc gccgggccgc cgccaccggc ggcgagtccc gcatcccagt
     8281 ggacgacatg acccgggagg tggtcgccga ggccgggtac gagctgcacg acgtgctgcc
     8341 cgagggacag gtgctggcgg tccggcgtac cgccaacctg cacaccggcg gcaccatcca
     8401 cgacgtcaca ggcgagctgc acccggtgat cgccgaggcg tgcgtggccg ccagccgggc
     8461 actggacatt ccggtcaccg ggctcgacct gctggtgccg gccccggacc agcccgagca
     8521 cgtcttcatc gaggccaacg agcggcccgg gttggccaac cacgagccac agcccaccgc
     8581 cgaacgcttc gtggatctcc tcttccccgg gacgcgggca ccgcaacggt tgtggacccc
     8641 cgcgggtgcg gcaacatctg gggcatgacc gtacgcaaga ccatcccgct cccgatcgac
     8701 ctggactatc tccagcaggt cctgctcgaa ctgctggaga ttcccagtcc gtccgggcgt
     8761 accgaccacg tgcagcagta cgtcggcgag cgactttcgg cgctcggcat tccgtcgacg
     8821 ctgacccgcc ggggggcgct gagcgcctgc ctgcccggcc cccgggagac cggggcggac
     8881 cgggcgatcg tggtgcacac cgacaccatc ggcgggatgg tcaaacggtt gaaggagaac
     8941 ggccggctgg aactgaacca gatcggcacg cacagcgccc ggttcgccga gggtgcccac
     9001 gtgcgggtct tcaccgacga cctggagcgg gtgatcaccg gtcaggtgct gccgctcaag
     9061 gccagcggcc accgctacaa cgaagcggtc gatctccagg gtgtcggctg ggagcaggtc
     9121 gaggtgcgca tcgacgaacc ggtggaggac atcgccggcc tgcgggcgct cggcatcgac
     9181 gcgggcgact tcgtggcctt cctgcccaac cccacgatca cccccagcgg gtacgtcaag
     9241 tcccgccacc tggacgacaa ggccggggtg gccgcggtgc tcaccgcgct gaaggccctc
     9301 gtcgacgcgc gggtgacgcc ggcggtcacc gcgcacctgc tgatcaccgt gaccgaggag
     9361 atcggccacg gcgcctccca cggcctcgac ccggacgtgg ccgagatcgt ctcggtggac
     9421 gcggcggtgg tcgcccccgg gcagcagtcc cgcgaggacg ccgccaccct ggcgatgggc
     9481 gacggggtgg ggcccttcga ctaccacctc acccgcaatc tggccgcgat cgcccgcgaa
     9541 cacgacgtcg acctggtccg ggacgtcttc gactactacc gctcggacgt ggcggcggcg
     9601 gtggaggcgg gcgcgcacgc ccgggttgcc ctgctcggct tcggcgtcga cgccacccac
     9661 ggccacgaac ggacccacct ggaagggctg cgccacctga cccagctgct ctgcctctat
     9721 ctccagagcg atctggtgtt tccggaatgg gacgccgagc ccgagggcga cctggcggac
     9781 ttcccgtcgc tgtcggtgca gccggccagc gaggaggggc cccgcgaggg cccgatcggc
     9841 atcgccccca acccctgagc cgcaggcccc gggcagatgt gatcgaaatc cgttgccggt
     9901 cggcgcgcgg ctggatagcg tggcggtaca cgggaaagga ggtggtccag acttgtatag
     9961 caatcggact cgtgaggtgg ctgtccgcta gccgctgtcc tcgacagtga tccgtccttc
    10021 gggcgggcag taagagtcgt cgagaccgtg tggcagcggt gcggcgaatc cacgaccagc
    10081 cacccgaccc ccggggtgcc gacccagtcc agtcggcccg cgtcagcgcg gaagccccgg
    10141 gggtcgcttt catatccgcc ggagggtgcc gtgtcgatgc gcgagttggt ggtgctcggt
    10201 acggccagcc aggcccccac ccgggtacgc aaccacaacg ggtacgtgct gcggtgggac
    10261 gacgaggtga tcctcttcga cccgggtgag ggcagccagc ggcaactgct gcacaccggc
    10321 gtcaccgcca ccgacctgac ccggatctgc gtcacccact tccacggcga tcactgcctc
    10381 ggactgcccg gcaccatcca gcggctctcc ctggaccggg tgtcgcatcc ggtggcggtg
    10441 cacttcccgg ccgagggggc cgactacttc gcccggctgc ggcacgccag ctccttctac
    10501 gagaccgcag agctggccgt gacaccgatc gaggcggacg ggcagcggat cgcgctgcgc
    10561 tgcggcaccc tggaggcccg ccggctgcgc caccccatcg acacgtacgg ctatcggctg
    10621 gtggaaccgg acgggcaccg catgctgccg gagaagctgg ccgcgtacgg catcggtggg
    10681 ccggcgatcg gcgagttgca gcgcgtcggc cacctcgacc tggacggacg ccgcgtcacc
    10741 cgggccgagg tgagcgtgcc ccggcccggc cagcggttcg ccttcgtgat ggacaccggc
    10801 ctctgcgacg cggtgtacgc gctggccgag gaggccgacc tgctggtgat cgagtcgacc
    10861 ttcctggagt cggaggccgc gctcgccgcc gaggtcggcc acctcaccgc cggtcaggcc
    10921 gcccgggtgg cggccgagtc gggggtacgc cgcctggtgc tcacccactt ctcccagcgg
    10981 tacgccgacc cgcgtcgctt cgccgacgag gcccgcgccc acttcgacgg cgacctggtg
    11041 atcgccgagg atctggtgac agttgcggtg ccaccccggc gggtaccctc ggcccagtga
    11101 tcgtcaccct gcggcccgcc accgctgatg acctgatgtt ggtggggcgg ctgcaccagc
    11161 ggtcgcggat cgccgcgtac tcctcgttcc tgccggcggc ggcactggcc cacccgacgc
    11221 ccgacgcgat gggcgagtac tgggtggccc ggtggacata cgagcgggcc gaccatcgga
    11281 tgaccgtcgc cgagcgggac ggcacactcg tcggcttcag ctacctcggc cccgacgacg
    11341 agggcgcccc cgacaccggg ctgctcaacg ccatccacct ggagccgacc gaacgcggtc
    11401 ggggcaccgg ccgggagttg atggtcgacg ccctggccgc catgcgggag cgcggctggc
    11461 gccacgccgc gctctgggtg ctgcgcgaca acgcccgtgc ccgccgcttc tacgaaggcg
    11521 gcggctggca gcccaccggc ctggagcgcg acgagatgat cggcgacgcg cacaccccgc
    11581 agctgcgcta cggccgccgc ctctgaccgg ccggctgtca ccctcagctt ccgtcctggt
    11641 ccgagtcgac cccgaagttg atcacaccga ggtagccgtc accgtcctcg gtcaccttca
    11701 gcaacatgct gtcggcgtag atcgagtcgt tgtcgttgaa cgtgtcccgg ccggtgtgcg
    11761 ccgcgtacgg ctgttcggcg tagaccttag agttcagcgt ctcgtcgaac atcacctgag
    11821 tggtgagcac ccgggagttg tcgatgtgca ccatcgcgtg gatgtgcacc gtacgacccc
    11881 ggtaccagcc gggccagatg gtggtgaact cgacgatgcc gtcggcattc gtgacctgcg
    11941 ccccacgcag gtaacgctgg tcgtcggtcg gggtcagatc gcccatgtcc ccgcctccgg
    12001 tatctcctcc ggtgtcgcct ccggtgtcgc ctccgccggg agcgccggag ccgccggggg
    12061 cattgccggg cggtgtgccg ccgggaccgc cgctgggcgg tgtgccgcca gggccgccgc
    12121 tggcgccgtt cgcgcctgac gactgcgctt cggcaccgga atagagcccg gccgcgtcgc
    12181 agtgccagat ctccaccacc gcgttcgcca gcggcccgca ctgctcgctg tcctgcaccc
    12241 ggatggcgag ccggagcagc gcaccctcgc gatcctcccg gatgtcgcta cggatcttgt
    12301 cggcgtcgaa atagtacggc ccctgggtgg tgctcgccgt cagggtgcag gtgttcgccc
    12361 cgtcgaacaa cgaggtcaag tcactggcgg tggtcgcctg cggggcgacc gtctcacccg
    12421 tcgaggtggt cacggtgcca ccgtcgcgcc cgcaggcggc cagcagcccg accagcccca
    12481 ccgaaccgat cccggcgatc agccgtcgcc ggctgacccg ctgcccctca tggtcgtcgt
    12541 accccatcgc cgctctccca tcatcgtgtc tggcagcgac gatatggacg gcaggtaggc
    12601 agagcctttg ccgctgttgt gcctccgctg tgcgttcgac ctcgctgcgg ggcagccatg
    12661 tggggctagg tgttgagcgc gcggggccgg acgttgagca cgcgggctgg atgttgcgcg
    12721 ggcgaggttg ggtgttgcgc gggcggggtg ttgcgcgcgc gaggttgggt gttgcgcggg
    12781 ctgggtgttg cgcgcgcgag gttgggtgtt gcgcgggctg aatgttaaga aggggcccct
    12841 gctatgcatg aggcgttagc aggggacccc tccttacatc ctcagcgggc gccgaggtgg
    12901 gcgagcaggt cttgacgggt gagtacgccc cggggcttgc cgtcgatcag caccagagcg
    12961 gcgtccgact tctccagcag gctcaccgcc tcgctcaccg gctggccgcc accgatcatc
    13021 ggcagcggcg accccatgtg ccgctcgatc gtgtcgtgca gctgcgcctg gccggtgaag
    13081 agcgcgtcga gcaggtccct ttccgcgatc gagccggcca cctcgccggt gaccacgggc
    13141 ggctcggcct tgagcaccgg caactgggag acgccgtact cgcgcatgta gtcgaccgcg
    13201 tcccggaccg tctcggtcgg gtgtacgtgc accagctcgg gcagcccacc tggcttgccg
    13261 gcgagcgcct ccgccacggt cggttcggag ccggagttgt cgaggaagcc gtaccgggcc
    13321 atccaggtgt cgttgaagat cttggacagg tagccccgac cgccatccgg cagcagcacc
    13381 acgatcacgt cgtccgggcc ggcggcgcgg gccacctcga gcgcggccac ggcggccatg
    13441 ccgcaggagc cgccgaccag cagcccctcc tcgcgggcca gccggcgggt catctcgaag
    13501 gactgcttgt cggagacctc gatgatctgg tcggccacgt cacggtcgta cgtctccggc
    13561 cagaagtcct cgccgacccc ttcgacgagg tacggccggc cggtgccgcc ggagtagacc
    13621 gagccctccg ggtcggcacc gatgatcttc accgtaccgc cggacacctc cttcaggtac
    13681 atgccgatac cggagatggt gccgccggtg cccaccccgg tgacgaagtg ggtgatccga
    13741 ccctcggtct gcttccacag ctccgggccg gtcgtctcgt agtgcgagcg cgggttcgcc
    13801 gggttggcgt actggttggg cttccaggcg ccggggatct cccgcgccag ccggtcggag
    13861 acgttgtagt acgagcgggg gtcctccggc gcgacggcgg tcgggcagac caccacctcg
    13921 gcaccgtacg cccgcagcac gtcctgcttg tcctggctga ccttgtcggg gcagacgaag
    13981 acgcagcggt agccacgcag ctgcgccacc agagccagcc cgacgccggt gttgccgctg
    14041 gtcggctcga cgatggtgcc gccaggccgg aggatgcctg ctgcctcggc gtcctccacc
    14101 atgcgcagcg cgattcggtc cttcaccgag ccaccggggt tgaggtactc caccttcgcc
    14161 agcacggtcg cctggatgcc ctcggcgacg ttgcgtagcc gtaccagcgg ggtgttaccg
    14221 atcatctcga cgacgttgtc gtagtactgc acctcgttgt gcccttctgc tccggcgccg
    14281 gcgccgcagg ccgggcgggt tgctcacgtg aatcccgcgc ccagggtacg tcggatcagg
    14341 gcaccgcgtg cccggggatg accgagctgc gacgggcctc ccattccagg aatcgttcgg
    14401 tctcggccag caccgagccg gccagccagg tgaccatcac cgcgtcgtcg atcagcccga
    14461 acacggtgag aaacatttcc ggcaccgcgt cgatcgggga gacgatgtac gcggtcgccg
    14521 ccgtcatcat ggccaaccgc aggccgccgt cgtactggcc gcgggcggtc gccgcgatca
    14581 tcctgggcag cgccccgatc cgcgcgccga gcgacgggcc gccccgggcc ccggccgtca
    14641 gcgcccggcc cagggctacg aaagccgcac cccgcttcaa cgtcttagcc atcgtcgtgc
    14701 tcctctccac gtgcagcgtg acgacccggc gcaacactca ttattcaagt acccaactga
    14761 gtcgttttcc aggcaccgca ggggccgccg tgacgacagc ggaccgtcgg accggcgcgc
    14821 tagtgtcgcg gtgtgggggt tgccgaatct gtcgtacc
//
