LOCUS       NZ_AP023358            25167 bp    DNA     circular CON 30-MAR-2024
DEFINITION  Micromonospora endophytica strain NBRC 109090 chromosome, complete
            genome.
ACCESSION   NZ_AP023358
VERSION     NZ_AP023358.1
KEYWORDS    RefSeq.
SOURCE      Micromonospora endophytica
  ORGANISM  Micromonospora endophytica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1
  AUTHORS   Komaki,H. and Tamura,T.
  TITLE     Whole genome shotgun sequence of Jishengella endophytica NBRC 109090
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 6586761)
  AUTHORS   Ichikawa,N., Komaki,H., Tamura,T. and Uohara,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2020) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :https://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.4
            Genome Coverage                   :: 293x
            Sequencing Technology             :: SMRT cell 8 Pac V3
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018326245.1-RS_2024_03_29
            Annotation Date                   :: 03/29/2024 14:26:01
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,248
            CDSs (total)                      :: 6,184
            Genes (coding)                    :: 5,715
            CDSs (with protein)               :: 5,715
            Genes (RNA)                       :: 64
            rRNAs                             :: 3, 3, 3 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 3, 3 (5S, 16S, 23S)
            tRNAs                             :: 52
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 469
            CDSs (without protein)            :: 469
            Pseudo Genes (ambiguous residues) :: 0 of 469
            Pseudo Genes (frameshifted)       :: 323 of 469
            Pseudo Genes (incomplete)         :: 166 of 469
            Pseudo Genes (internal stop)      :: 12 of 469
            Pseudo Genes (multiple problems)  :: 30 of 469
            CRISPR Arrays                     :: 4
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 16:19:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1660394
            Orig. end                         :: 1685561
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023358.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Annotated at DFAST https://dfast.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25167
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25167
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25167
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15167](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15167
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(276..919)
                     /locus_tag="Jiend_RS07745"
                     /old_locus_tag="Jiend_16090"
                     /pseudo=""
     CDS             complement(276..919)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013732961.1"
                     /locus_tag="Jiend_RS07745"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16090"
                     /product="HAD family hydrolase"
                     /pseudo=""
                     /sec_met_domain="HAD_2 (E-value: 1.1e-12, bitscore: 46.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRSVVFDVGETLLDDTREFQAWADWLRVPRHTLSALVGIVVAQG
                     RNNAEAFQYLRPGIDLSVERERRERAGHGEMISEADLYPDVRPALAELRRLGLWVGVAG
                     NQTSRAAELLRQLALPVDAVATSGEWGVAKPDPRFFTRVVEFACGSADEILYVGDHRDY
                     DVRAAQAAGLRSVLIKRGPWGICGLATP"
     gene            1100..1558
                     /locus_tag="Jiend_RS07750"
                     /old_locus_tag="Jiend_16100"
     CDS             1100..1558
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018349054.1"
                     /locus_tag="Jiend_RS07750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16100"
                     /product="DUF296 domain-containing protein"
                     /protein_id="WP_111243543.1"
                     /transl_table=11
                     /translation="MRSHDLTPGRMIGVVFDHDDEFFTALADACRAHGIKQGYIPMFIA
                     GLSTAKIVYTCQRLDNPDAPVWTHVDLINVEALGGGTIAWDDTNQRILPHVHLTAGLKE
                     HSATAHTSHLLDATVQFLTEMLIIEVSSPAMRRLPNTDLYDVPQLHLG"
     misc_feature    1511..1513
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(1702..1716)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.19"
                     /tool="antismash"
     gene            1848..2855
                     /locus_tag="Jiend_RS07755"
                     /old_locus_tag="Jiend_16110"
     CDS             1848..2855
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16110"
                     /product="hypothetical protein"
                     /protein_id="WP_146603493.1"
                     /transl_table=11
                     /translation="MLAATTDAELGLYSPRRTPDAVRSGQVQEQPATRRPLHVRVGGKL
                     LDGDPEAWLHELDEFTNQPMRTWPQLRGQVQEYLEVLDDLQGCHVRPHLARVDARWSEF
                     MSWIADNTAPPEGWAWLDRSHRRAIEADDASLAAYTLMRQSQRALDNGDVRAAIAFSRR
                     SLAPSSVPARTRALCLTRMAEALAASGDDEARTAITAARRELPGADANAVDEDDFARHC
                     DPRYIAAVDAPCRHLLGDPASATAIFEELLSDLAAIAPIDAGLWHAHLAECYLHHDPER
                     AVDHGMTALRLADETASYRVIRATQPLAIALRRHSALPSARAFIDRHRTAVTTQ"
     gene            2868..3584
                     /locus_tag="Jiend_RS07760"
                     /old_locus_tag="Jiend_16120"
     CDS             2868..3584
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019033894.1"
                     /locus_tag="Jiend_RS07760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16120"
                     /product="creatininase family protein"
                     /protein_id="WP_111243541.1"
                     /transl_table=11
                     /translation="MDLLPLITSTDVAASAPEVAVLPVGSFEQHGSFLPLTTDTIVATA
                     IAAAIARQHNVLVLPPITLSCSHEHAAWAGTVSISHQTLSAIIEDIRSSLAASGITRLA
                     IVNGHGGNYVLSNIVQTANAVTPGSMTLFPTRTDWAKARQDARLDSDAHHDMHAGELEV
                     SILLHVQPHAVGEDFTAGDHAADDRPMLLVHGMSAYTKTGVIGRPSAGTAAKGEALLAS
                     LAQSFDDHLAALLSQG"
     gene            3625..4998
                     /locus_tag="Jiend_RS07765"
                     /old_locus_tag="Jiend_16130"
     CDS             3625..4998
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16130"
                     /product="hypothetical protein"
                     /protein_id="WP_146603492.1"
                     /transl_table=11
                     /translation="MPRHPDTVITPNRLLVQARQRLTSPQRPGQHLSRAELADAINTAL
                     DHLYPGRNLTAHYVDHRWVGKLERGEHRWPSRERRTALRHVLAATTDAELGLYSPRRTE
                     SRAIPDRRQVTAAWFGKLPGDLTQLPGPWTSERGLQAPTRIESPHVEALQRSIALFEEW
                     DHQHGGGLARAAMAGQLEWACLVARQASATETVRRTWLATAARLADLAGWACFDSGDAP
                     ATTQRYLVMAMQLATEAEDVQQRAHTATTLGRHLTYVGQVSDALDVIGLVHSDWRGIPP
                     LGRAAVRIVEARAYAKSHDSQACIRAVAQCDEEFAASGLDGAEDPVWGYYADAGQILGD
                     AGHALFDIAMATHDRQQMAMTISRLQSAYSYHPMGAARSRALTMIRIACLQVRNGNFAS
                     GLNSVRAGLTDARGVHSSRLRDDLRVLDSVLANSDPEPSLAGELAAARAHVAECVRQV"
     misc_feature    4039..4041
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4995..5864)
                     /locus_tag="Jiend_RS07770"
                     /old_locus_tag="Jiend_16140"
     CDS             complement(4995..5864)
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018789024.1"
                     /locus_tag="Jiend_RS07770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16140"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_111243539.1"
                     /sec_met_domain="APH (E-value: 9.4e-19, bitscore: 66.8,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRAEEAIDAVTSAATGAGLSAHDATVVRVGENGVVLLPSAGVLAR
                     VLPRAAKDSNPRREIEVAAWLASRQVPVVHPARPEPIIVGQYVVSLWEYLPDSRPADLV
                     TLARCLRRVHAVAVPTDLLPYLSPFDKFEERLEAGAGLDVHDRLFLRQFRGDLSARWAT
                     TKFTLGEGVLHGDAHMENLLVTADGREAFVDLETVCIGPPEWDLTLTALYYECGWFSAT
                     QYVEFVQTYGFDVRLSPSWPVLRLIRMLRMTLWLAQSADNDPQRQCQLRHRIATLRDGT
                     APAGWTGY"
     misc_feature    complement(5103..5105)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6409..6870
                     /locus_tag="Jiend_RS07775"
                     /old_locus_tag="Jiend_16150"
     CDS             6409..6870
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16150"
                     /product="hypothetical protein"
                     /protein_id="WP_212808822.1"
                     /transl_table=11
                     /translation="MLVDRLAVLIVVGVGPDQVGTAAAGGGEPGAEDGEGLVGQHVGLD
                     VDAVGGEHGGAAVASGGRVEDADDDSGDAGVDEFLAAGRGDADVVAGFECDDGGAASRC
                     GARCAERVHFGVGFSFAAVIAGADNVTMAIEDDAADGRVWARGAQAERR"
     gene            complement(6915..8156)
                     /locus_tag="Jiend_RS07780"
                     /old_locus_tag="Jiend_16160"
     CDS             complement(6915..8156)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07780"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16160"
                     /product="hypothetical protein"
                     /protein_id="WP_181445153.1"
                     /transl_table=11
                     /translation="MPRHPDTTIRPNTALIEARHRLSSPMRPGQCMSRSELADAVNAAL
                     DRIYVGRDVTAHYVDFRWLGKLERGEHRWPSQARRAALRQVLGAATDADLDLYSPRRSD
                     GTGVIDETIEPRPGSWDETIHLLREQWHLLVQNDKMFGPEYALMGVIRQLTAIEGLPNE
                     VPQALRPAVIRLAAQYAESAAWLHQSLNDHAAGHRRTRQALAWAGQIADPTMTAWATYR
                     SSQQWLTSGHPAQAVEQAEAALLYDQKLPGPMRAALRVQHAHSLAATGEHRAALRLLDA
                     AHRWAADRHPGKPEGEHGSYCTSGYIEVHRGACLRLAQRPQEAIDVIDEALPTIPRRHR
                     QDFAAALLNKAMAHAAANQPDQAAATAHRALPIARRAGSRRILHQLAHLGTAVSGHQQL
                     PEVRAFLDGLKKDT"
     misc_feature    8296..8309
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.69"
                     /tool="antismash"
     misc_feature    complement(8297..8310)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.6"
                     /tool="antismash"
     gene            8434..9639
                     /gene="fxlM"
                     /locus_tag="Jiend_RS07785"
                     /old_locus_tag="Jiend_16170"
     CDS             8434..9639
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="Jiend_RS07785"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16170"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_111243538.1"
                     /sec_met_domain="PCMT (E-value: 7.1e-42, bitscore: 142.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTSDQRVQDPAVLRAAMVSELREDTIASEAVAAAFSVVPRHLF
                     APGEPLEVVYEANTPLVTKTGPDGTALSSVSAAHIQAVMLEQAEIEPGMRVLEIGSGGY
                     NAALIAELVGAEGSVTSVDIDPEIAARARVCLRSAGYERVRVLQADAEYGVAEHAPYDR
                     IIVTVGAWDIPPAWIEQLSERGRIVVPLRFAGLSRCIAFDRSGPGLVSHSYCLGGFVPM
                     QGEGTFTETVVPINGEATLRLDGPDSGFDVPALRKAMHGPKIERWSGAAFDLPDELELF
                     VVTSAPQVPFLYASQQLVDHGVFTPAVTYGAAVLVEGGSFAYRTKRENEDTGGWESGVF
                     AYGARAEAVAGRYVGLLRRWAAQYRRRGAARIEYIPTGGDGAAPVGWYAPKRHGVVAVS
                     WP"
     misc_feature    8476..8478
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            9709..9903
                     /locus_tag="Jiend_RS07790"
                     /old_locus_tag="Jiend_16180"
     CDS             9709..9903
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="Jiend_RS07790"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16180"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_111243537.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 7.2e-16, bitscore:
                     56.4, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTERRTVSTAPTPADGMTGEFGPDDWELDVTFVESGESVDKLIYM
                     TNDGCGKTCQSACSTTCPK"
     CDS_motif       9709..9864
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MTERRTVSTAPTPADGMTGEFGPDDWELDVTFVESGESVDKLIYMTNDGCGK"
                     /locus_tag="Jiend_RS07790_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9865..9903
                     /prepeptide="core"
                     /locus_tag="Jiend_RS07790_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-100.00"
                     /molecular_weight="1139.3"
                     /monoisotopic_mass="1138.5"
                     /core_sequence="TCQSACSTTCPK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTERRTVSTAPTPADGMTGEFGPDDWELDVTFVESGESVDK
                     LIYMTNDGCGK"
                     /leader_location="[9708:9864](+)"
                     /alternative_weights="1157.3"
                     /alternative_weights="1175.3"
     gene            10001..>12009
                     /locus_tag="Jiend_RS07795"
                     /old_locus_tag="Jiend_16190"
                     /pseudo=""
     CDS             10001..>12009
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="Jiend_RS07795"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="Jiend_16190"
                     /product="lantibiotic dehydratase family protein"
                     /pseudo=""
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.2e-174,
                     bitscore: 579.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.3e-16,
                     bitscore: 59.6, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVRVAVCAPDRLPVGWPDLTGSGAGAASWRPWLRQVLAVPEFAAS
                     LEQASPVLIERVRAVCGGRTMGERERRRVVVSVLRYLLRACGRATPYGLFAGVATARLA
                     PTTAVRVGDGHLAVARVRAQWLAGLVDRIESDPMVRPYLTVRANNLLTCRDGRIVLGYR
                     PHQAPGEALTQVHVRATGPVRAALAAARDPIRLNDLADKLATDHAVATSTVRALLAKMV
                     SQRLLLTALRPPTTSTDPLSAVMTGLDQVLADVDDNSVGHDALVHARSTRDGLRALIKQ
                     VTRHNATPSGATGQHRDRLATTMAALHPADEPPVAVDLRLDVDLRLPDAVAVEAAAAAG
                     VLVRLAAVERAGWAAWHRRFLERYGPHALVPVRDVVDADVGLGFPAGYQDAPPAPPVAL
                     TERDRKLLALAQGAALRRQREVVLDDALIRSLSGGVPITRVQPSTEMTVSVQARTAQDL
                     DEGEFRLAVVGVSRNAGTTTGRFLDLFGPTDRQRIAGQYAAVPTATRGALLAQVSAVTP
                     YTITEDVARAPQMMPHAITLGEYHDNASGRIAVDDIAVTADADRVYLVSVSRRCVVEPV
                     VLNAVEQTYYTLPIVRFLAEAPVAFTVPCSAVDWGAANDLPFLPALRYRRTILSPARWL
                     LPASTLPAPTPPGESGPRASPRGVTRSPARRRCT"
     aSDomain        10430..10702
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_Jiend_RS07795_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="5.70E-19"
                     /identifier="RREFam001.1"
                     /label="Jiend_RS07795"
                     /locus_tag="Jiend_RS07795"
                     /protein_end="234"
                     /protein_start="143"
                     /score="59.6"
                     /tool="antismash"
                     /translation="TVRANNLLTCRDGRIVLGYRPHQAPGEALTQVHVRATGPVRAALA
                     AARDPIRLNDLADKLATDHAVATSTVRALLAKMVSQRLLLTALRPP"
     misc_feature    11906..11908
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            12229..13044
                     /locus_tag="Jiend_RS07800"
                     /old_locus_tag="Jiend_16200"
     CDS             12229..13044
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="Jiend_RS07800"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16200"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_249412415.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2e-29, bitscore:
                     101.6, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNVREHGHLPGTDGRLYLKLYGHPDRQTAILTRHLPTLLNRLGPH
                     ARWWFLRYGDPDPHLRLRLTGGSLDGLVGEWAQHLRRAGLVARVQVDTDYPETARFGGP
                     TATTTVEKVFAADSAAALTQLTVSDRHQETDVRAVTAASLVDITTAFIGDTVGGLRWLI
                     DHIRPHQPAPPREVYQRAVQLANPDQSGLAELSGGEELRARWGLRRQALSAYRDTLRTL
                     PDGPDSLLPDLLHLHHTRMIGPDPDSERICLHLARAAALSWTTRARSHP"
     misc_feature    12331..12333
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            13041..13925
                     /locus_tag="Jiend_RS07805"
                     /old_locus_tag="Jiend_16210"
     CDS             13041..13925
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="Jiend_RS07805"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16210"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_212808620.1"
                     /sec_met_domain="LANC_like (E-value: 8.9e-17, bitscore:
                     59.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRPHPAALAAATATAEALADPRAIHRESLDRRARPQSLAGGAVG
                     IALLHIERARAGRGDDAAAHAWLKLAASQPISAGGNANLFHGAPALGFALHAAGTTQYR
                     RTLSAIDDTTIALTRTRLAAAHARIDRDEPLLMREFDLIHGLTGLGVYHLHRHPAHPIT
                     RDVLGYLVRLTHHRPSSTGPEGLPPWWMSVGLSGEPHPDHPHGHGNIGVAHGINAVIAL
                     LSLAVLHNLHDVGIHDALARLCAWTDEWRRDDSTGAWWPGYLTIDHVRRLAPPQRPDPP
                     GATASLAPPGPNN"
     gene            13817..14269
                     /locus_tag="Jiend_RS32080"
     CDS             13817..14269
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="Jiend_RS32080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_212808621.1"
                     /sec_met_domain="LANC_like (E-value: 2e-13, bitscore: 48.4,
                     seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARLPHHRPRPPPRTTPTPRPSWCYGIAGTARAQQLAGIALDDTT
                     RQITAEHAMLAALRDPSQRALLPEIGLCHGKAGLLQSAFRMAVDARSPALVAELPDLAA
                     HLATQLTQNMTDPELMDGAAGAALALHAVGTSATPASAWDAVLLLA"
     gene            14361..15167
                     /locus_tag="Jiend_RS07815"
                     /old_locus_tag="Jiend_16230"
     CDS             14361..15167
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="Jiend_RS07815"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16230"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_249412416.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.5e-36, bitscore:
                     122.4, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVAHLVPMLTEAEAEKLITAWFFIRKTPQWRLRYLPATMQARTH
                     LLDRLHTLERDQLIATAVEVVYEPETRAFGGTPAMTVAHRLWHADSRHVLDYLATTAAD
                     PTARHRRELAILLTSTLLRAAGLDWYEQGDVWNKVANHRPPPDAPDPNTIPALHAALRK
                     LMGTDLTTVTTPSTPRAAAAGWAAAYAAAGHDLAHLAAAGRLHRGLRDVMAHHIIFAMN
                     RLGLSATTQAILATNAATAIFGPDPTTQPTTRNPCRTPPTATEAAS"
     misc_feature    14508..14510
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15169..16293
                     /locus_tag="Jiend_RS07820"
                     /old_locus_tag="Jiend_16240"
     CDS             15169..16293
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16240"
                     /product="hypothetical protein"
                     /protein_id="WP_146603601.1"
                     /transl_table=11
                     /translation="MDATTAQARRFPLVARPRPSCIPLPERVADISRRAAAANRDHDAA
                     AASAVFNLAALLASDCGLPNLARQWSTRLARAALAHPPQDFRTASHSLEPVINLARLRT
                     RAADGTGAWTILQQLHRAVTNRTDTSIDGITVPASRLAPDRSEHRELRRWLWAVLLSSG
                     AHALAVAGRWDDAYHQLHQNHGIGRRMLDGRQIAVIAHTLAGRHSHAMTLLRDTKPGEP
                     WEHAVTCRLVLLCQQGATSSRQRDQAVRAYQALTPAAEGLAVFHTRLGLSLIDALGSIH
                     QPAAQPIATDLIKRAAGDGYTARDLLTHPACRSLLTPRQAAQLTDVVTACGLDTGTIPT
                     PLLTELAHALDTAEDTLTSTSPDTNPIHPHQAPG"
     gene            16302..16718
                     /locus_tag="Jiend_RS07825"
                     /old_locus_tag="Jiend_16250"
     CDS             16302..16718
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16250"
                     /product="hypothetical protein"
                     /protein_id="WP_249412361.1"
                     /transl_table=11
                     /translation="MQRLVTATDDTTHSPLGAAPDQTRVHEQADKDLGFLDRHGALTRD
                     LRGVLIHHVLFLFNRLGISATDTWLLATAAVHVTFHHSSDIPPGYQPAETLRVTEADCE
                     GRHTPRATTRALRSTSDQLRRPVPTGIALRRLAQ"
     misc_feature    16347..16349
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            16925..17683
                     /locus_tag="Jiend_RS07830"
                     /old_locus_tag="Jiend_16260"
     CDS             16925..17683
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Jiend_RS07830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Jiend_16260"
                     /product="hypothetical protein"
                     /protein_id="WP_146603602.1"
                     /transl_table=11
                     /translation="MTNEAESSGDEGLPAFRPARKPRPIFAGTAAHRFPELRAPRAHLD
                     RLRVHHIDLVRRVLEVDGGKIYLPDLLVMSMMQRSYGLVEAVVDCVDGYNLAAAAPLLR
                     MQLDTLVRACYVAHVPVADDVVTAMLKGTEFRRMKDADGKPLTDARLIELAAPHHPWLP
                     PVYKETSGWVHLSLNHLRAAWQITGDQISSGVPLWPDVIPGKLWLELLEAMTTATEQLF
                     GYVEMWESRKGLPLGQARGWPDAEPEPSAR"
     misc_feature    17228..17230
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(19494..20780)
                     /locus_tag="Jiend_RS07835"
                     /old_locus_tag="Jiend_16280"
     CDS             complement(19494..20780)
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018791529.1"
                     /locus_tag="Jiend_RS07835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Jiend_16280"
                     /product="IS256 family transposase"
                     /protein_id="WP_111246680.1"
                     /transl_table=11
                     /translation="MTATLNEQSGRKKRPEASAEAKAAAELVRAAKEQGLSLTGPEGLL
                     KQLTRTVLETALNEEMTDHLGYAKHEPDGAGAGNIRNGTRSKTVLTDTSGPVQIDVPRD
                     RAGTFEPQIVRKRQRRLSGVDEVVLSLYAKGLTTGEISAHFAEIYGASVSKETISRITD
                     KVIEEMTDWSHRPLDAVYAAVFIDAIVVKVRDGQVANRPFYAAIGVTLDGEKDILGLWA
                     GSGGEGAKFWMSVLTDLRNRGMKDVFFCVCDGLKGLPEVVTNVWPRTIVQTCVIHLIRN
                     TFRLTSRRYWDELKRDIKPIYTAVNAAAARAAFDELTEKWGSRYPAVIRLWDNAWAEFI
                     PFLDYDLEIRKVICSTNAIESLNARYRRAVKARGHFPNEQAALKCLYLVTRSLDPTGTG
                     RTRWTMRWKPALNAFAITFSDRFPTAETY"
     gene            21303..>21668
                     /locus_tag="Jiend_RS07840"
                     /pseudo=""
     CDS             21303..>21668
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013753.4"
                     /locus_tag="Jiend_RS07840"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLTHPDRLPPEQTRNLHDVQAACPHLTAAGQHVRAFAKMLTNLTG
                     LQHLSEWIDNVRADDLPHLRQFADGLRTDYDAILAGLSTPWSSGQVEGQNTRAKLIKRL
                     GYGRANFDLLRKRILLQA"
     misc_feature    21805..21820
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    21879..21894
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    21953..21968
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22026..22041
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22098..22113
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22171..22186
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22245..22260
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22318..22333
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22394..22409
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22465..22480
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22538..22553
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22611..22626
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22685..22700
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22759..22774
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22831..22846
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22905..22920
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    22978..22993
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23065..23080
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23138..23153
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23210..23225
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23282..23297
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23354..23369
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    complement(23391..23405)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.42"
                     /tool="antismash"
     misc_feature    23426..23441
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23500..23515
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23572..23587
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23646..23661
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23718..23733
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23789..23804
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23862..23877
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    23935..23950
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24009..24024
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24084..24099
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24159..24174
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24233..24248
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24305..24320
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24377..24392
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24432..24446
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 17.49"
                     /tool="antismash"
     misc_feature    24449..24464
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24523..24538
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24594..24609
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24667..24682
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24740..24755
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24813..24828
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24888..24903
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    24963..24978
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    25033..25048
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
     misc_feature    25105..25120
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 22.22"
                     /tool="antismash"
ORIGIN
        1 ccagacgccg ccctgcgcgt ggctgagggc tgggccccac cgacaaccgt tctcagcgaa
       61 cgtcggtccc acttctacat cgacctggcc cgcgcccacg ctaagacggg ctctcctgcg
      121 caagccctcg atgcgctgct gcacgcaagg acagcagcgc ctgaacacac ccgcatccac
      181 cctcacgtgc gtcaggtcct caccctgctg cgctcacgag catcgacgga cgaccgcctc
      241 tctgagtacg cgcgatgggc atcggcagcg gtcggctaac ccggccgaac cagaccgggc
      301 aactgctcca acgactccag cacccagaca ccgtgctcgg ccatcacggg gtcgccagcc
      361 cacagatgcc ccaagggcca cgcttgatca gcaccgaccg cagcccagca gcctgagcag
      421 ctctcacgtc atagtcacgg tggtcaccga cgtacaggat ctcgtccgcg ctgccgcagg
      481 cgaactcgac aacccgcgtg aagaaccgtg gatccggttt ggcaacgccc cactcgccgg
      541 acgtcgcgac agcatcgacc ggcagcgcca attgccgcag cagttcggcg gcccggctgg
      601 tctggttgcc agccacacca acccacaacc cgagtcttcg caactcagcg agggcaggac
      661 gaacgtccgg atacagatca gcctcgctga tcatctcacc gtgaccagca cgctcacggc
      721 gctcacgttc gaccgagaga tcgatgccgg gacgcaggta ctgaaacgct tcggcgttgt
      781 tgcggccctg cgccacaacg atccccacca aagccgacaa ggtatgcctc ggcacgcgca
      841 gccagtcagc ccacgcctgg aactcccgag tgtcatccag cagcgtctca ccgacatcga
      901 acaccacaga cctgatcacg tacgacacct ccgggaaggg ccagcgatct actctaaagg
      961 gctgccctcc gggcggcact cccatctatg ggagagccat ctggtgcggc cccggcggaa
     1021 tgtctactcc gtggacttcc gccaaagccc tagccgacac caacacggac cagcgaccga
     1081 acggagacac cagcggcgca tgcgtagcca cgacctgacc ccaggacgga tgatcggtgt
     1141 ggttttcgac cacgacgacg aattcttcac cgccctcgct gacgcctgcc gcgcccacgg
     1201 catcaaacag ggctacatcc cgatgttcat cgccggcctg tccacagcca agattgtcta
     1261 tacgtgtcaa cgcctcgaca accccgacgc ccccgtctgg acgcacgtcg acctgatcaa
     1321 cgtcgaagcc cttggcggcg gcaccatcgc ctgggacgac accaaccaga ggatccttcc
     1381 ccatgtccac ctcacggctg ggctcaagga gcacagcgcg accgctcaca ccagccacct
     1441 gctggacgcc accgtccaat tcctcaccga gatgctcatc atcgaggtca gctcaccggc
     1501 catgcgtcgg ttaccgaaca ccgacctgta cgacgtacca caactgcacc tcggctgaac
     1561 gttcgcaacc ctgacccacg agggaggtgg agatgccgcg ccaccccgac accgtcatca
     1621 cgcccaacag gctgctcgtc caggcccgcc aacgcctgac gtccccacaa cggcccggcc
     1681 aacacttgtc ccgagccgag ctggccgacg ccatcaacac cgccctcgac cacctctacc
     1741 ccgggcgaaa cctcaccgcc cactacgtcg accacagatg ggtcggcaaa ctcgaacgtg
     1801 gagaacaccg ctggcccagc cgcgaacgcc gcactgccct ccgccacgtg ctcgccgcca
     1861 ccaccgacgc cgaactcggc ctctacagcc cgcgacgcac tccggacgcc gtccgatccg
     1921 gccaggtcca ggagcagccg gctacgcgcc ggccactcca cgtccgcgtc ggtggcaaac
     1981 ttctcgacgg cgatccagag gcatggctac atgaactcga cgagttcacg aaccaaccca
     2041 tgagaacctg gcctcaactc agaggccagg tgcaggagta cctcgaagtc ctcgatgatc
     2101 tccagggctg ccacgttcga ccgcaccttg cacgggtcga tgctcgctgg tcggagttca
     2161 tgagttggat cgccgacaac accgccccgc ccgaaggttg ggcgtggctt gaccgatctc
     2221 accggcgcgc gatcgaggct gatgacgcct cgcttgccgc ctacaccctc atgcgtcaga
     2281 gccaacgcgc cctcgacaac ggcgacgtcc gcgccgcgat tgccttctca cgccgctccc
     2341 tggcacccag ctcggtaccc gcccggactc gcgcgctgtg ccttactcgc atggccgaag
     2401 cactggctgc cagcggcgac gacgaggcac gtaccgcaat cacggcggcc cgacgggagc
     2461 tgcccggcgc ggatgccaac gcagtcgatg aagacgactt cgcccgacac tgcgacccgc
     2521 gctacattgc cgcagttgac gccccctgcc ggcatttgct cggtgacccg gcatccgcca
     2581 ccgcgatctt cgaggaactc ctcagcgacc tagccgccat cgcaccgatc gacgccggcc
     2641 tctggcacgc ccacctcgcc gagtgctacc tgcaccacga cccggaacgc gctgtcgacc
     2701 acggaatgac cgcgctgcga ctagcggacg agactgcctc ctaccgtgtc atccgcgcta
     2761 cccagccact cgcgatagcg ctgcgccggc acagcgccct gccctcagcc cgggccttca
     2821 tcgacaggca ccgcaccgca gtgacaaccc agtgacaaga tgaccgcatg gacctcctgc
     2881 cgcttatcac cagcaccgac gtcgccgcaa gcgcacctga ggtagccgtt ctacccgtcg
     2941 gcagcttcga gcagcacggt tcgtttctgc cgctgaccac cgacacgatc gtcgccaccg
     3001 caatcgctgc ggccatcgcg cgacagcaca acgtcctggt cctgccgccg atcacgctgt
     3061 cgtgctcgca cgagcacgcc gcctgggccg gtaccgtcag catcagccac caaaccctct
     3121 cggcgatcat cgaggacatt cggtcctcgc tcgccgcgag cggaatcacc cggctagcca
     3181 tcgtcaacgg ccacggcggc aactacgtgc tgtccaacat cgtgcagacc gccaacgccg
     3241 tgacgcccgg ctcgatgacg ctgttcccga cccgcaccga ctgggcaaag gcccggcaag
     3301 acgcgcgctt ggacagcgac gcccaccacg atatgcacgc cggtgagctg gaagtgtcca
     3361 tcttgctgca cgtacagccc cacgcggtcg gcgaggactt caccgctgga gaccacgccg
     3421 cagacgaccg accgatgctg ctagtccacg ggatgagcgc gtacacgaag acgggcgtca
     3481 tcggccgacc ctcagcaggc accgcagcca agggcgaagc cctgttggca agcctcgcgc
     3541 agtcgttcga cgaccatctt gccgccctgc tgagccaggg gtgacggaac agtccgacac
     3601 gacccgcctg cgaaggaggc gagaatgccg cgccaccccg acaccgtcat cacgcccaac
     3661 aggctgctcg tccaggcccg ccaacgcctg acgtccccac aacggcccgg ccaacacttg
     3721 tcccgagccg agctggccga cgccatcaac accgccctcg accacctcta ccccgggcga
     3781 aacctcaccg cccactacgt cgaccacaga tgggtcggca aactcgaacg tggagaacac
     3841 cgctggccca gccgcgaacg ccgcactgcc ctccgccacg tgctcgccgc caccaccgac
     3901 gccgaactcg gcctctacag cccgcgacgc accgaaagcc gcgcgatccc cgatcgccgg
     3961 caagtaacgg ctgcatggtt cggcaagctg ccaggcgacc ttacgcagct tccgggaccg
     4021 tggacgtccg aacgcggatt acaggcaccg accaggatcg agtcacctca tgtcgaggcg
     4081 cttcaacgca gcatcgcctt gttcgaagag tgggaccacc agcacggtgg cggactcgct
     4141 cgcgccgcga tggccggaca gctcgaatgg gcctgtctgg tcgcccgtca agcgtcagcc
     4201 accgaaacgg tacgccgaac ctggctggcg acggcagccc gacttgctga ccttgccgga
     4261 tgggcgtgct tcgattcagg tgatgcaccg gcgaccaccc agcggtacct cgttatggcc
     4321 atgcagttgg ccaccgaagc cgaggacgtt cagcaacggg cacacaccgc caccacattg
     4381 ggccggcatc tcacgtacgt cgggcaggtc tcggacgctc ttgatgtgat tggccttgtt
     4441 cactcggatt ggcgcggcat tcccccactg ggacgtgcgg cggttcggat cgtggaggct
     4501 cgcgcctatg caaaaagcca cgattcgcag gcgtgcatcc gcgcggtcgc tcaatgcgat
     4561 gaggagttcg cggccagtgg gttggatggg gcagaagatc cggtttgggg ctactacgcc
     4621 gatgccggcc agattctcgg tgacgccggc catgccctgt tcgacatcgc catggccacc
     4681 catgaccgcc aacagatggc catgactatc agtcggttgc agtcggcgta ctcctatcat
     4741 ccaatgggag ctgctagatc gcgggctctc accatgatta ggattgcctg cctccaggta
     4801 cgcaacggta acttcgccag cgggttgaac tcggtacggg ctggcttgac tgacgcgcgg
     4861 ggcgttcact ccagccggct gcgcgatgac cttcgcgtac ttgattccgt cctcgcaaac
     4921 tccgacccgg agccgagcct tgcaggtgag ctcgcggcag cgcgggcgca cgtagccgag
     4981 tgtgtgcgcc aggtctagta gcccgtccag ccggcgggag cggttccgtc tcgcaacgtg
     5041 gcgatgcgat gcctcagctg gcactgtcgt tgcggatcgt tgtccgctga ctgagccagc
     5101 cataaagtca tccgcagcat gcgaatcagc cgcagcaccg gccacgacgg gctaaggcgg
     5161 acatcgaatc catacgtctg aacgaactcg acgtactgtg ttgcggagaa ccatccacac
     5221 tcgtagtaga gggccgtcag agtcaaatcc cattccggcg gtccaataca caccgtctcc
     5281 agatccacga atgcctctcg gccgtcggcc gtcaccagga gattctccat atgcgcgtcg
     5341 ccgtgcagca ccccttcacc gagcgtgaat ttcgtcgttg cccaccgagc cgagaggtca
     5401 ccccggaatt ggcgaagaaa tagacggtcg tggacatcga ggccagcgcc cgcctctagc
     5461 cgctcttcga acttgtcaaa cggcgacaag tagggcaaca gatctgtcgg gacggcaaca
     5521 gcgtgtaccc gacgcaggca tctggcgagg gtgaccaagt cggccggccg gctatcggga
     5581 agatactccc acagcgacac cacgtattgc ccaacgatga ttggctccgg ccgtgcgggg
     5641 tgcacgacag gcacttgtcg cgaggccagc catgcagcga cctcgatttc ccgacggggg
     5701 ttgctgtcct tcgccgccct tggtagcacc cgcgccagca caccggcgct tggcagcagg
     5761 accacaccgt tctcgccgac gcgcaccacg gtggcgtcgt gagccgatag gcccgctccg
     5821 gtggctgccg acgtcaccgc gtcgatcgcc tcttccgcac gcacccgacc atcctcccct
     5881 cggcgtggcc gaaccaactc gatgactccc cggccggcct cggcgtacct gctctaggct
     5941 catgcgttct aggtatggca ggcagtgctc gctcgacccc ggctgcggca gcagcgcatc
     6001 agcgcatgcc cggctgtgcg atgtcggctc gtccaaaaga cggcttgggc cggcgaaggc
     6061 gaacacgcac acccgtgcta ccgggcgaga tatcagccag ctcgaaaccc gctggcgtga
     6121 ggtctgcggt ggctgccgcg atgcccccgt cggtcgggct ctttcgatgg cgaccacgat
     6181 ctcatcgacg cagtcaaggt cgtcgtggag ctcgccggca tgatgggctc caacggccag
     6241 gatggttcgc gagccggtgg cgtagcaggc cgacagccac ggtcggagat cagcgctcag
     6301 gtcgtcgggc agcgtgaagt gttcgggcgc gtgaccgccg gggacgccct cctcgattgt
     6361 cttgtcgctg agcacgaggt ctgtcctact tcgcagatcc gcggttagtt gctcgttgac
     6421 aggctggctg tcctgattgt cgtaggcgta ggtccagatc aggtagggac ggcggcggcg
     6481 ggtggcggcg agccaggggc cgaggacggt gagggtctcg tcgggcagca cgttggtctc
     6541 gacgtcgatg ccgtgggcgg tgagcatggc ggcgccgccg tcgcctcggg aggtcgggtc
     6601 gaggacgctg atgacgactc gggcgatgcc ggcgttgatg agttcctggc ggcaggccgg
     6661 ggtgacgccg atgtggttgc agggttcgag tgtgacgacg gcggtgccgc ctcgcgctgc
     6721 ggcgcccgct gtgctgagcg cgttcacttc ggcgtgggct tctcctttgc ggcggtgata
     6781 gccggcgccg acaacgtcac catggcgatc gaggatgacg cagccgacgg gcgggtttgg
     6841 gctcgtggtg cccaagccga acgacgatag tgtgatcgct tgccgcatcg cggccaactc
     6901 gacgtcggat gccatcaggt gtccttcttg aggccatcta ggaaggcgcg gacttctggc
     6961 agttgctggt gtccgctgac tgcggtgccg aggtgcgcga gttgatgcag gattcgtcgt
     7021 gatcccgccc ggcgcgcgat cggcaaggcg cggtgtgccg tcgccgcagc ctggtcgggt
     7081 tggttcgctg cggcatgggc catcgccttg ttcagcaggg cggcggcgaa gtcctggcga
     7141 tgccgccgtg gaatcgtagg gagagcttcg tcgatgacgt cgattgcctc ctgtggccgc
     7201 tgcgccagcc gaagacacgc cccgcggtgc acttcgatgt agccgctggt gcagtaggag
     7261 ccgtgctcgc cctctggctt tcccgggtga cggtccgctg cccagcgatg cgcggcgtcc
     7321 agcaggcgca gcgccgcgcg gtgttcgcct gtggcggcga gggagtgcgc gtgctggaca
     7381 cgcagcgccg cccgcatcgg tccgggaagc ttctggtcgt agagcagcgc cgcttcggcc
     7441 tgctcgacgg cctgggcggg gtgtccgctg gtcaaccatt gttggctgct gcggtaggtg
     7501 gcccaggcgg tcatggtcgg gtcagcgatc tggcctgccc aggcgagagc ctgtcgtgtc
     7561 cggcggtggc ctgcggcgtg gtcgttgagg gattgatgca gccatgccgc ggattcggca
     7621 tactgggcgg cgaggcggat gacggcgggg cgaagcgctt ggggcacctc gttcggaagg
     7681 ccctcgatcg ccgtcaattg tctgatgacg cccatcagcg cgtactcggg gccgaacatc
     7741 ttgtcgttct gcaccaggag atgccactgt tcgcgcaaca ggtggatggt ctcgtcccaa
     7801 ctgcctggtc ggggctcgat cgtctcgtcg atgacgcctg ttccatcgct tcgtcgaggg
     7861 ctgtagagat cgagatcggc atcggtggcg gcgccaagta cctgacgcag cgctgctcgc
     7921 cgcgcttggc tgggccagcg atgctcgcca cgctccagct tgccgagcca acggaagtcg
     7981 acgtaatggg cggtgacgtc acggcccacg taaatccggt cgagcgccgc gttgaccgca
     8041 tcggccagct cactgcggga catgcactgg ccaggacgca tcggcgagga caggcgatgc
     8101 cgggcctcaa tgagcgcggt gttcggcctg atcgtggtgt ccggatgacg aggcaccgac
     8161 ttcccctcta cccagcatgc cgacctctgc cgactatgcc accggttgtc tagatcatcc
     8221 agctctcacg ctgtcacacc tcgtagcgac acgaatcacc gtgaagtcgg accgcaagtc
     8281 ggtattcccc tgatgttcac gatgagtgat cgtgtgtggc gtacttggtg aggttccggc
     8341 aaggaccttc ccattctccg atcactgcca cggagagcaa cgtcgctgct cgacgcacgg
     8401 cggtagtcaa tcaagtagct gaggtgggaa cacatgacga ccacaagcga tcagcgtgtc
     8461 caggatcccg cggtgttacg tgcggcgatg gtgtcggagt tgcgcgagga caccatcgcg
     8521 tcggaggccg tggccgctgc attctcggtc gtgccccgtc acctgttcgc acccggcgag
     8581 ccgctggagg tggtgtacga ggcgaacact ccgttggtga cgaagaccgg tccggatggc
     8641 acggcgctca gctccgtctc ggcggcgcac atccaggcgg tgatgctgga gcaggccgag
     8701 atcgagccgg ggatgcgggt gctggagatc gggtcgggtg ggtacaacgc ggccttgatc
     8761 gcggaactcg tcggtgccga gggttcggtg acgtcggtgg acatcgaccc ggagatcgct
     8821 gctagggccc gtgtctgcct gcggtcggcc ggctatgagc gggtgcgggt gttgcaggcc
     8881 gacgccgagt acggcgtggc ggagcatgcg ccgtatgacc gcatcatcgt cacggtgggt
     8941 gcgtgggaca tcccgccggc ttggatcgag cagctgtcgg agcgaggccg gatcgtcgtg
     9001 ccgttgcggt tcgccgggct gtcgcggtgt atcgcgttcg atcggtctgg gcccgggctg
     9061 gtgagccaca gttattgcct tggtgggttt gtgccgatgc agggcgaggg cacgttcacc
     9121 gagacggtgg taccgatcaa cggtgaggcg accctgcgcc tcgacggtcc ggattcgggc
     9181 ttcgacgtgc cggcgctgcg taaggccatg cacgggccga agatcgagcg gtggtccggg
     9241 gcggccttcg acctgcccga cgagctggag ctgttcgtgg tgacgagcgc tccgcaggtg
     9301 ccgtttctat atgccagtca acagctcgtg gaccacgggg tgttcacccc ggcggtgacg
     9361 tacggcgctg ccgtactagt cgagggtggc agtttcgcgt accggaccaa acgcgagaac
     9421 gaggacaccg gcgggtggga gagcggtgtc ttcgcgtacg gggcgcgcgc cgaggcggtc
     9481 gccgggcggt acgtggggct gttgcggcgc tgggcggcgc agtaccgccg ccgcggtgcc
     9541 gcgcgcatcg agtacatccc caccggtggg gacggggccg ccccggtggg gtggtacgcg
     9601 ccgaagcgcc acggcgtcgt cgcggtgtcc tggccctgac agctgccggc gtcccgcccc
     9661 ggggcgctgg aggtatcaca accctcgaag gaggctgtcg tgtcgatcat gaccgagcgg
     9721 aggactgttt caacggcgcc aacacccgca gacgggatga ccggcgagtt cggtccggat
     9781 gactgggagc tggacgtcac gttcgtcgag tccggcgaga gcgtcgacaa gctgatctac
     9841 atgaccaacg acgggtgcgg caagacctgc cagtcggcgt gtagcaccac ctgcccgaag
     9901 taggccgaga tccaggggcg tctggccgcg cggtagttgc cgtgtggtca gacgcctcgc
     9961 ccgtgaggga ggacgcgtgt accgacatct ggacgccgtg atggtgcgtg tcgcggtgtg
    10021 cgctccagat cgtttgcctg tcggatggcc ggatctgacc gggtcggggg ctggcgcggc
    10081 gtcgtggcgg ccgtggttgc ggcaggtcct cgcggtgcca gagttcgccg cctcgctgga
    10141 gcaagccagc ccggtactca tcgaacgcgt tcgcgcggtc tgcggtggcc ggacgatggg
    10201 tgagcgtgag aggcggcgag tggtggtgtc ggtcttgcga tacctgctgc gggcctgcgg
    10261 gcgggcaacg ccatacgggc tgttcgccgg ggtcgccacc gcccgcctgg cgccgaccac
    10321 agcggtacgg gtcggtgacg ggcacctagc ggtggcgcgg gtacgtgccc agtggttggc
    10381 cggcctggtc gaccgcatcg agtccgatcc gatggttagg ccgtacctga ccgttcgcgc
    10441 caacaacctg ctgacctgtc gcgacggccg catcgtgctg ggttaccgtc cccaccaggc
    10501 tccgggcgag gcgctcaccc aggtgcatgt gcgcgctacc ggtccggtcc gtgccgcgct
    10561 ggctgcggcg agggatccga tccggctcaa cgatctggcg gacaagctcg ccaccgatca
    10621 tgctgtcgcc accagcacag tgcgtgcgct gttggcgaag atggtgtcgc agcggctcct
    10681 gctgaccgcg ctacggccac cgaccacgtc caccgacccg ctgtccgccg tcatgacagg
    10741 actcgaccag gtgttggccg acgtcgacga caacagcgtt ggccacgacg cactcgtcca
    10801 tgcacggtcc acgcgcgacg ggctgcgcgc cctgatcaag caagtcacac gacacaacgc
    10861 gaccccgagc ggggccaccg ggcagcatcg tgaccggctt gccacgacga tggctgctct
    10921 gcatcccgca gacgagccac cggtggcggt cgatctgcgg ctggacgtcg acctacggct
    10981 tcccgacgct gtcgcggtgg aggccgcagc agccgctggc gtactcgtgc gcctcgccgc
    11041 tgtcgaacgg gcgggatggg cggcgtggca ccgccgtttc ctggaacgct acgggccgca
    11101 cgcgctggtc ccggtccgcg acgtggtgga cgccgatgtc ggcctcgggt tccccgccgg
    11161 ctaccaggat gccccgcccg cgccaccggt ggccctgacc gagcgggatc ggaagctgct
    11221 ggccctggct cagggggcgg cgctacggcg tcagcgcgag gtcgtactcg acgacgcctt
    11281 gatccgcagc ctgtccggag gggttccgat cacccgggtg cagcccagca ctgagatgac
    11341 cgtcagtgtt caggcccgca ccgctcagga cctcgatgag ggcgagttcc ggctcgcggt
    11401 cgtcggcgtg tcccgcaacg cgggcaccac caccggccgg ttcctcgacc tcttcggccc
    11461 aacggaccgg cagcgaatcg ccggacagta cgcggctgtg cccacggcaa ctcgcggtgc
    11521 gttgctcgcg caggtgtcgg cggtgacccc gtacacgatc accgaggacg tcgcccgcgc
    11581 cccgcagatg atgccgcacg ccatcacgct cggggagtac cacgacaacg cctccgggcg
    11641 gattgcggtg gacgacatcg cggtcaccgc cgacgccgac cgcgtgtatc tggtgtcggt
    11701 gtcccggcgt tgtgtggtgg agccggtcgt gctcaacgct gtcgagcaga cgtactacac
    11761 cctgccgatc gtgcggttcc tcgccgaagc tcccgtcgcc ttcaccgtgc cgtgtagtgc
    11821 cgtcgattgg ggtgccgcga acgatctgcc gttcctgccc gccctgcgct accggcggac
    11881 catcctgtcg ccagcgcgct ggctgttacc agccagcacc ctgcccgccc cgacgccgcc
    11941 tggggagagt ggacccaggg cctcacctcg tggcgtgacg cggtcgcctg cccgcagacg
    12001 gtgtacctcg gtgatggcga ccagcgcatc agcctggacc tggccgcgcc cgcgcaccag
    12061 gcattgctcc gcgattacct gaaccgccgg ccgacagcgc tgctgcgggc cgcaccacca
    12121 ccggacgccg ccgagtggat cggcggccat gcacacgagg tcgtcattcc cctcgcggcc
    12181 acgggcgatc cggcgccccc gccgcggcta ctcgccacca caccggtggt gaacgtccgc
    12241 gagcacgggc atcttcccgg cacggacggt cgcctctacc tcaagctgta cggtcacccg
    12301 gaccggcaga ccgccatcct cacccggcac ttaccgaccc ttctgaaccg gctcggccct
    12361 cacgcccggt ggtggttcct ccgctacggc gaccccgacc cacacctgcg tctgcgactc
    12421 accggcgggt ccctcgatgg tctggtgggc gagtgggccc agcaccttcg ccgcgctggc
    12481 ctggtcgccc gggtgcaggt cgacaccgac tacccggaga cggcccgctt cggcggaccc
    12541 accgccacca ccacagtcga gaaggtgttc gccgccgact cggcggctgc cctcacgcaa
    12601 cttaccgtca gcgaccgcca ccaggaaacc gatgtccgtg cggtgaccgc cgcgagcttg
    12661 gtggacatca ccaccgcctt catcggcgac acggtcggag gtttgcgatg gctgatcgac
    12721 cacatccgcc cgcaccagcc cgccccgccc cgcgaggtct accagcgtgc cgtccagctg
    12781 gctaaccccg accagtccgg cctggcagag ctgtcgggcg gtgaagaact ccgcgcccgg
    12841 tggggccttc gccgccaagc cctgtccgcc taccgcgaca ccctacgaac cctcccggac
    12901 ggccccgaca gcctgctgcc cgacctcctg catctgcacc acacccgcat gatcggacct
    12961 gacccggaca gcgaacgcat ctgcctgcac ctggcccgcg ccgccgcgct gagctggacc
    13021 acccgcgcac ggagccaccc atgaccagac cacacccggc cgcgctggcg gcggccacgg
    13081 caaccgccga ggcgctagcc gacccgcgag ctatccaccg cgagtccttg gataggcggg
    13141 ccaggccaca gtccctcgcc ggcggcgcgg tcggcatcgc cctcctgcac atcgaacgcg
    13201 cccgcgccgg ccgcggcgac gacgctgctg cccacgcctg gctgaaactc gccgcctccc
    13261 agcccatcag cgccggcggc aacgccaacc tgttccacgg cgcgcctgcc ctcggcttcg
    13321 ccctgcacgc cgccggcacc acccagtacc ggcgcactct gtccgcgatc gacgacacca
    13381 cgatcgcgct cacccgcacc cggctggccg ccgcccacgc ccgcatcgac cgcgacgaac
    13441 cactactgat gcgcgagttc gacctgatcc acggcctgac cggactcggc gtctaccacc
    13501 tgcaccgcca ccccgctcac cccatcaccc gcgacgtgct cggctaccta gtccgcctca
    13561 cccaccaccg cccgagcagc accggtcccg aagggttgcc gccgtggtgg atgtctgtgg
    13621 gattgtccgg cgagccccac ccagaccatc cgcacgggca cggcaacatc ggcgtcgccc
    13681 acggcatcaa cgccgtcatc gcgctgctgt ccctcgccgt cctgcacaac ctgcacgacg
    13741 tcggcatcca cgacgcactc gcccggctct gcgcctggac cgacgaatgg cgccgagacg
    13801 acagcacggg tgcctggtgg cccggctacc tcaccatcga ccacgtccgc cgcctcgcac
    13861 caccccaacg ccccgaccct cctggtgcta cggcatcgct ggcaccgccc gggcccaaca
    13921 actagccggc atcgccctcg atgacaccac ccgccaaata acagcggaac acgcgatgct
    13981 cgccgcgctg cgcgatccca gccaacgcgc gctgctcccc gaaatcggcc tgtgccatgg
    14041 gaaagccggc ctgctccagt ccgcctttcg catggccgtc gacgctcgca gccccgccct
    14101 ggtcgccgaa ctgcccgacc tcgcagctca tctcgccacc caactgactc agaacatgac
    14161 cgaccccgag ctcatggacg gagccgccgg agccgccctc gcactgcacg ccgtcggcac
    14221 cagcgccacg cccgcatccg cctgggacgc agtcctcctc ctggcctgac cgcccccgcc
    14281 cactatgcaa ggacggccgt gataccccac cctggcttca gatcaccatc gaactatccg
    14341 accccgtcca ggccgacgac atcgccgtcg ctcacctggt gcccatgctc accgaggcgg
    14401 aggccgagaa gctcatcacc gcatggttct tcatccgcaa gacaccccaa tggcggctgc
    14461 gctacctccc cgccaccatg caggcgcgaa cccacctgct cgaccgctta cacacactcg
    14521 aacgcgacca gctcatcgcc acagcggtcg aagtcgtgta cgagccggaa acccgcgcct
    14581 tcggtggcac cccggcgatg accgtggcgc accggctgtg gcacgccgac agccgacacg
    14641 tcctggacta cctcgccact accgcagcag accccaccgc ccggcaccgg cgagaactcg
    14701 cgatcctgct caccagcacg ctgctacgcg ccgccggtct ggactggtac gaacaaggcg
    14761 acgtctggaa caaggtcgcc aaccaccgac caccacccga cgcacccgac cccaacacca
    14821 tcccggcact gcacgccgcc cttcgaaagc tgatgggcac cgacctcacc accgtcacca
    14881 cgccaagtac gcccagggcc gccgctgccg gctgggccgc agcgtacgcc gccgccggcc
    14941 acgacctggc tcacctcgcc gccgcaggtc gactccatcg cgggctacgc gacgtcatgg
    15001 cacaccacat catcttcgcg atgaacaggc tcggcctatc cgccaccacc caagccatcc
    15061 ttgccaccaa cgccgccacc gccatcttcg gccccgaccc caccacccag cccacgaccc
    15121 gaaacccctg ccgcacaccg ccgacagcta cggaagccgc tagctgatat ggacgccacc
    15181 acagcacaag cccgaagatt ccccctcgtc gcccggcccc gaccctcctg catcccgctc
    15241 cccgaacgcg tcgccgacat cagccgccgc gctgccgccg ccaaccgaga tcacgatgcc
    15301 gccgccgcgt cagccgtgtt caacctcgcc gcgctgctgg cctccgactg cgggctaccc
    15361 aacctggccc gccaatggtc aacacgtctg gcccgcgccg cgctcgctca ccctccacag
    15421 gacttccgga ccgcaagcca cagcctagag cccgtcatca atctcgcgcg actacgcacc
    15481 cgcgccgcag acggcaccgg cgcctggaca atcctccaac agctccaccg ggccgtcacc
    15541 aaccgcaccg acaccagcat cgacggcatc accgtccccg cctcccgcct ggcacccgac
    15601 cgcagcgaac accgagaact ccgccgctgg ctgtgggcgg tcctgctctc cagcggcgcg
    15661 cacgccctag ccgtcgccgg acgatgggac gacgcctacc accaacttca ccaaaaccac
    15721 ggcatcggcc gccgcatgct cgacggccgg cagatcgccg tcatcgccca caccctcgcc
    15781 ggcaggcaca gccacgcaat gaccctgcta cgcgacacca agcccggcga accctgggaa
    15841 cacgctgtca cctgccgcct tgtcctgctc tgccagcagg gcgccaccag tagcaggcag
    15901 cgcgaccagg ccgtgcgcgc ctaccaagca ctgacccccg ccgcagaggg cctagccgtg
    15961 ttccacaccc gcctcggact ctccctcatc gacgccctcg gcagcatcca ccagccagca
    16021 gcacaaccca tcgccaccga cctcatcaag cgggccgctg gggacggata cacagcccga
    16081 gacctcctca cccaccccgc ctgccgcagc ctcctcacac cacgccaggc cgcgcagctc
    16141 acggacgtcg ttaccgcctg cggactcgac accggcacca tcccgacacc cctgctcacc
    16201 gaactcgccc acgcgctcga caccgccgaa gacaccctca ccagcacttc ccccgacacc
    16261 aaccccatcc acccgcacca agccccgggc tgatcgccgc cgtgcagcgc ctggtcaccg
    16321 ccaccgacga cacgacgcac agcccattag gcgccgcccc cgatcagacg agggtccatg
    16381 agcaagcaga caaagacctc gggttcctcg accgacacgg cgcactgacc cgcgacctgc
    16441 gcggcgtgct gatccaccac gtcctgttcc tgttcaaccg gctcggcatc tcggccaccg
    16501 atacctggct cctggccaca gccgccgtgc acgtcacctt ccaccactcg tccgacatcc
    16561 cacccggcta tcaacctgcc gagacgctcc gagtcaccga ggccgactgc gaaggtcgac
    16621 acactccccg ggcgacgaca cgcgcgctcc ggtccacatc tgaccagctc cggcggccgg
    16681 ttccgacggg gattgcgctg aggcgcctgg cccagtagtg ctttgctagg ctaccgtgcc
    16741 gcgagttacc gatattggtg cgactcgcac cgacagcagg tacgccaatg agagtggcat
    16801 gcgagtgccg gtcgacccgg gtcagcaacg agcgtcgggt gtcgacacgg gtgtcggtgg
    16861 cgtcgcctgt agcccctgcc gaaactggga tgcccgaatg gcctcacgtc cgaataatga
    16921 acgcgtgacg aacgaagctg agagcagcgg cgatgaaggg ttgcccgcgt tccggccggc
    16981 gcgaaagccg cgaccgatct ttgctggtac cgccgcccat cgcttcccgg agctacgcgc
    17041 gccgcgtgcg catctcgatc ggttgcgcgt tcaccatatc gacctagtgc gccgcgtgct
    17101 tgaggtcgac ggcggcaaaa tttacctgcc ggacctcttg gttatgtcga tgatgcagcg
    17161 gagctacggc ctggtggaag cggtcgttga ctgcgttgac ggttacaact tggcggcggc
    17221 ggctccatta ctccggatgc aactcgacac cctcgtgcgg gcttgctacg tggcgcatgt
    17281 tccggtggcc gacgacgtgg tcacagcgat gctaaagggg accgagttcc gcaggatgaa
    17341 ggatgccgac gggaagccgc tgaccgacgc gcgcctgatc gagcttgcgg cgccgcatca
    17401 cccgtggctt ccgccggtct acaaagaaac gtcaggctgg gtgcacctct ctctcaatca
    17461 tctccgcgcc gcgtggcaga ttaccggcga ccagatcagc tctggcgttc cgctctggcc
    17521 cgacgtaatc cccggaaagc tctggttgga gttgctggag gcgatgacca cggcgaccga
    17581 gcaactcttt ggctacgtcg agatgtggga gagccggaag gggctaccgc tcgggcaggc
    17641 gcgaggatgg ccggatgctg agcctgaacc gagcgccaga tagcaaccct tgctcgctgc
    17701 tgcactacag cccagattgt gcaggtctcg ccggaatcct ggcgtcggcc gactacgcgc
    17761 cggtagcggg gagtaggcat tggcacggag actggtgggg cgatagccat cggcacgctg
    17821 ttcctcgggg ttcgggtcca tgcactttgg cgtgtacctg actagtagcg gaacttgcac
    17881 gccggcagcg atggcgccga acgcacccga gccaggagaa gtggggccga tagcgacccg
    17941 gtcctcggcg cgtggtcgcg cctgcgatga cgggtcagct tgccaccaag ccacgtggcg
    18001 aggatccagc cggccgactc gacccgctgg ccacctcgcg gacgcgcggg gaagcggggc
    18061 caggagaaac tgaagacagg tccacgtcgg tctcgatggt gccagaaaag tggaaaccgg
    18121 gtccggaaca ggcgcgaacg aacggctggc cttggcggag ggctggcaca ttgtccgcgc
    18181 atgatatgac ggtcgatgtg acggtgatcg cggcccttct gcttctctgc atcatcgctc
    18241 tgatggtcgg ctggatggtc gtcgcgtcgg cgttcggtgg catgctgctc tggacggtgc
    18301 aatggagatg cgtgtcgtcc gaggcgtttc agccgatccg gcgtcacgga ttgcggagag
    18361 gcgggtggga gttactcctg tcggcggctg ggcccggggt tctgcgccgg ctggttgcgc
    18421 gcgagtcgtg gaggcgtgtg ctgctgctgt tgctggtgcc gttagttggc ttcatggtgc
    18481 cggttagtct cccctatgtc gtcgtccttc tggtgccgga atccgtcgcg agcggtgagt
    18541 tcgggcaggc gatcgagagg gtctgtctct tcacaggatc tctcggcgcg ttggtagcga
    18601 ttcgcgtctt ctgtaaaggt ttgcaataca tcgcgcagcc cgacaagcca cgcggcaaga
    18661 ttccggccct gcgttttccc gacagtctgt ccagccaggg tcggcaccgg ctcgccacga
    18721 acgcattctg gtacagggcg gtcgataccg gcgagttgct cgctggcaca tatcccgtcc
    18781 tggtcctgtt tgcggtgctg gccgacctaa agactttcac cgcgcagccg tcagaggccg
    18841 acacctcgct tccgccgctt cttggcatca tcgtcgtcgt cctggcgttg acgccgttgt
    18901 tcatcccggc gcatatcgct gcctctcgtc tgcgccgtcg ccttgccgga tggcagttgt
    18961 cggtggagat ctgtcaggtg ctggcaccgc cccgcgagca agaggaggac gacccgctgg
    19021 agcttccgga aaccctcagc acgctggccg acgcccaccg cagccagctt gtcgagatcg
    19081 ctgtgctact caatcaaact gcaatgctgt gggaccgtcg acaatcacca gggttcgcac
    19141 cgcaccctgc ggcgaccgtg cttcgtgccg tcggcacgtc gatccgccgc cacctgcaaa
    19201 gccctcaatc gtgcgatccc gcgctccccg gtgacgtgcg agagacacta cgcatggtgc
    19261 tggacctgct cgtagagccg aaccgcccat cgttgttgcg cgaactcgcc tcccgagtcc
    19321 aggcgttcga cgaagacggg aggcccgccg tcgagacatt cgtcaagccg cccggccgcc
    19381 tcgcagtggc catgacgagg ctgaccgaca gcacacagcg aaccgccgcc gtcctagctg
    19441 caatgaccgg aatggcgggc ctgtctcgcc aacggtgttt ccggcgatct tggttagtag
    19501 gtttcagcgg tcgggaagcg gtcgctgaag gtgatggcga aggcgttcag agcgggtttc
    19561 cagcgcatcg tccatcgggt cctgcctgtg ccggtggggt ccagggaccg ggtcaccagg
    19621 tacaagcact tcaacgcggc ctgctcgttc gggaagtggc cacgggcctt caccgcccgc
    19681 cggtagcggg cgttcaacga ctcgatcgcg ttcgtggaac agatgacctt gcggatctcc
    19741 aggtcgtagt cgaggaacgg gatgaactcc gcccaggcgt tgtcccacag gcggatcacc
    19801 gccggatacc tgctgcccca cttctccgtg agttcgtcga acgccgccct ggccgcagct
    19861 gcgttgacgg cggtgtagat cggcttgatg tcgcgtttca actcgtccca gtagcggcgg
    19921 gaggtgagcc gaaacgtgtt gcggatcagg tggatcacgc aggtctgcac gatcgtgcgg
    19981 ggccacacgt tcgtcacgac ctcgggcagg cctttcaggc cgtcgcagac gcagaagaac
    20041 acgtccttca tgccccggtt gcgcaggtcg gtgagcacgc tcatccagaa cttggcgccc
    20101 tcaccacccg agccggccca caacccgagg atgtccttct ccccatcgag ggtcacgccg
    20161 atcgcggcgt agaacggccg gttcgcgacc tgcccgtcac ggaccttgac cacgatcgcg
    20221 tcgatgaaca ccgccgcgta gacggcgtcc aagggtcggt gggaccagtc ggtcatctcc
    20281 tcgatgacct tgtccgtgat ccgcgaaatc gtctccttgc tgaccgaggc gccgtagatc
    20341 tcggcgaagt gcgccgagat ctccccggtc gtcaaaccct tggcatacag cgacaacacc
    20401 acctcgtcga cccccgacag gcggcgctgc cgcttgcgga cgatctgcgg ctcgaaggtg
    20461 cccgcccggt cccgcggcac atcgatctgc accggccccg acgtgtcggt caggaccgtc
    20521 ttcgaccggg tcccattgcg gatgttgccc gccccagcac cgtcgggttc gtgcttggca
    20581 tagccgaggt gatcggtcat ctcctcgttg agcgcggtct ccagaaccgt cctcgtcaac
    20641 tgcttcaaca gcccttccgg accggtcaac gacaggccct gttccttcgc ggcccggacc
    20701 agctcagcag cggccttcgc ctccgccgac gcctcaggcc gcttcttccg tccggactgc
    20761 tcgttcagtg tcgcggtcat cacggcaccc tcctcaccag gcacaacgcc cggcaggtca
    20821 ggccggaaac accgttagat ccacacgccc ggaatggcgg ccacgttcat ggctgtcgcg
    20881 ctggctctcc tgggtgagat cgactccgat gtgttacttg gtcacctcaa ataggccgcc
    20941 acctcggtgt gtgggcagtc caagtcgttg gtcgggtccg agaagttgct ttcatccaac
    21001 aggcgcgttc accccgagga catctggcaa aaggtgcagt agccatgcgt acgtgtctgg
    21061 agctagatct tcgggtactt cggcctcgcg tgcgctcatg agttcgccga gtaggttgcg
    21121 gagttcggcg gagtgcccct cgatgtaggc ggcgcgcatg aggtcgtgcc acggcccgtc
    21181 gtcgcctctg tggggatcgg ctgcccaagc ttgttgaacg gcccagcggg cgttcgtcgt
    21241 gtcgctggcg tccaggtaca tggtcgcgag ttggtgggcg gtgtcgacga tggcggatcc
    21301 tgctgctcac ccatcccgac cggctaccac ccgagcagac ccgcaaccta cacgacgtcc
    21361 aagcggcatg cccgcacctg accgctgccg gccagcatgt gcgcgccttc gccaagatgt
    21421 tgaccaacct caccggccta cagcatctat ccgagtggat cgacaacgtt cgggcggacg
    21481 accttcccca cctgcggcag ttcgccgacg gactccgaac cgactacgac gccatcctcg
    21541 ccggcctctc cacaccgtgg agctccggcc aggtcgaagg acagaacacc cgggccaagc
    21601 tgatcaaacg cctcggctac ggccgcgcga acttcgacct gctccgcaaa cggatcctgc
    21661 ttcaagcgtg gacatcgcca caagatcagc gacagagccc gctcccgcgt acctacctgt
    21721 gcactcgggc ctgtacgccg acacgaaccg ccagcgccgg cccccacggt gagcttgccg
    21781 gcccgcgggt cgatgttgag atcctcgccg acggcgaacc gccagcgccg gctgcgggga
    21841 acatcgccgt gcaggtgacg ccgttgacgt tgagatcctc gccgacggcg aaccgccagc
    21901 gccggcggcc ttgccgacgt cgtacccgag ccggttgagc cggttgagat cctcgccgac
    21961 ggcgaaccgc cagcgccggg tcctcacctg accaggcgtg ttcctcccgg tagtcgttga
    22021 gatcctcgcc gacggcgaac cgccagcgcc ggttgttgca gccccacgcg cagaccaacc
    22081 cgatggagtt gagatcctcg ccgacggcga accgccagcg ccggggtgcc ggtaaccgac
    22141 tacagccggc gtcgtgaccc gttgagatcc tcgccgacgg cgaaccgcca gcgccggtcc
    22201 ggtccatgta gtggccgtcg agcggacccg ggtcgttgag atcctcgccg acggcgaacc
    22261 gccagcgccg ggacgtacaa gcgggccagc acgacgacgg tgcgcgtgtt gagatcctcg
    22321 ccgacggcga accgccagcg ccggcctcga cgaccggctc tacaccgacg tcgaactcga
    22381 cctgttgaga tcctcgccga cggcgaaccg ccagcgccgg cggcgatggc tgggccggtg
    22441 gtgatcttcc cgccgttgag atcctcgccg acggcgaacc gccagcgccg ggcgggtctt
    22501 cttcaccaag atcccgcccc acccgaagtt gagatcctcg ccgacggcga accgccagcg
    22561 ccggctgctc caccgtgctg ggtggccgcg cgccgcccac gttgagatcc tcgccgacgg
    22621 cgaaccgcca gcgccggggt cgaccagctc gtccgcgatc cggtcgagcc cgttgttgag
    22681 atcctcgccg acggcgaacc gccagcgccg gacggcacga gcggcatcac cgcgaccgcg
    22741 agctgcacgt tgagatcctc gccgacggcg aaccgccagc gccggtcggt cagtgtgcgg
    22801 tcgccgatct ccagcgcggt gttgagatcc tcgccgacgg cgaaccgcca gcgccggtgg
    22861 gcagcgcttc caggtcggcc agggagtggg tgatgttgag atcctcgccg acggcgaacc
    22921 gccagcgccg gccgcgcgcc gcattcctcg ctgacggtgc gcgcccggtt gagatcctcg
    22981 ccgacggcga accgccagcg ccggttgtgc tcccggatcg tcttccggaa cgcgccacgg
    23041 gccgtccgct ccaggttgag atcctcgccg acggcgaacc gccagcgccg gggtcgcggt
    23101 ggcggccagc aacggcggca aaaccttgtt gagatcctcg ccgacggcga accgccagcg
    23161 ccggtagggt ccaccgttgg attggcaggc aacgaacggg ttgagatcct cgccgacggc
    23221 gaaccgccag cgccggtcgt ccagggccgt cgatccggct gcgcacgatc agttgagatc
    23281 ctcgccgacg gcgaaccgcc agcgccggcc ggaccgcctc gccaccgacc cgcgccatga
    23341 acggttgaga tcctcgccga cggcgaaccg ccagcgccgg agccccgccg aggccgagca
    23401 catccagcgg cagtggttga gatcctcgcc gacggcgaac cgccagcgcc ggtgcagacc
    23461 ggccgactgc acgaagacgg agtgacccgg ttgagatcct cgccgacggc gaaccgccag
    23521 cgccggttgg gaccgaaagg cgagagaggc agtcgctaag agttgagatc ctcgccgacg
    23581 gcgaaccgcc agcgccggac gcagtcttgc tgccgccgcc acgcaacggg gtgatgttga
    23641 gatcctcgcc gacggcgaac cgccagcgcc ggttcgccgt gtccccggcc gcccacagcc
    23701 tgtatatgtt gagatcctcg ccgacggcga accgccagcg ccggccgccg gctggcacgc
    23761 cctgtacgac cccgacgggt tgagatcctc gccgacggcg aaccgccagc gccggccgcc
    23821 caccctggcg tgcgacggca cccaggccca ggttgagatc ctcgccgacg gcgaaccgcc
    23881 agcgccgggc atcggctgcg tcaccggacc tcaccgccct gggcgttgag atcctcgccg
    23941 acggcgaacc gccagcgccg gtcgatcgac aggagaaggg atctaagggt ggcaagtagt
    24001 tgagatcctc gccgacggcg aaccgccagc gccggtgtcg gacggcaccc cgccgaccgc
    24061 gcccaacccg aacgttgaga tcctcgccga cggcgaaccg ccagcgccgg tacgtggcgg
    24121 cctcgatgag cccctcgccg ccccgggtgt tgagatcctc gccgacggcg aaccgccagc
    24181 gccggtcccc atcgccatcc acgacggccg cacccaaacc tggttgagat cctcgccgac
    24241 ggcgaaccgc cagcgccggt tgcgggtctc gtaatgattg ctgaggtcag taacgttgag
    24301 atcctcgccg acggcgaacc gccagcgccg ggcgcggccg gaccggggcc gcgtcgccac
    24361 atgaaggttg agatcctcgc cgacggcgaa ccgccagcgc cgggtgacgc tgcgagtcga
    24421 gatggcccgc cggctcatgt tgagatcctc gccgacggcg aaccgccagc gccggccgag
    24481 ttgttcggcc cgaagtcatg atcgtcgtgc atgttgagat cctcgccgac ggcgaaccgc
    24541 cagcgccggt cgtcgacgtc gtgctcccgc acgggcgcga ctggttgaga tcctcgccga
    24601 cggcgaaccg ccagcgccgg tccgacggcg tacgcggctg ccgacagcgc attgaggttg
    24661 agatcctcgc cgacggcgaa ccgccagcgc cggtgtcgta ccgagggtct gccccgacac
    24721 ggtgagggtg ttgagatcct cgccgacggc gaaccgccag cgccggtgtc gtaccgaggg
    24781 tctgccccga cacggtgagg gtgttgagat cctcgccgac ggcgaaccgc cagcgccggc
    24841 cggtaccgac ggacagggcc atcgtggcca gctccgggtt gagatcctcg ccgacggcga
    24901 accgccagcg ccgggcccat gggtcgagct tgcggacctg gcagaagtgg atgttgagat
    24961 cctcgccgac ggcgaaccgc cagcgccggc cgcaagcgcg gcgagacacc cgccgcgttt
    25021 atgttgagat cctcgccgac ggcgaaccgc cagcgccgga cccgaccccg gagccggacc
    25081 cggtcaagcc gtgagttgag atcctcgccg acggcgaacc gccagcgccg cgccaccacc
    25141 gccgcgctac cggcagccga cgagccg
//
