LOCUS       NZ_AP023356            11785 bp    DNA     circular CON 27-APR-2024
DEFINITION  Actinoplanes ianthinogenes strain NBRC 13996 chromosome, complete
            genome.
ACCESSION   NZ_AP023356
VERSION     NZ_AP023356.1
KEYWORDS    RefSeq.
SOURCE      Actinoplanes ianthinogenes
  ORGANISM  Actinoplanes ianthinogenes
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Actinoplanes.
REFERENCE   1
  AUTHORS   Komaki,H. and Tamura,T.
  TITLE     Whole genome shotgun sequence of Actinoplanes ianthinogenes NBRC
            13996
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 9897806)
  AUTHORS   Ichikawa,N., Komaki,H., Tamura,T. and Uohara,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-AUG-2020) Contact:Director-General Biological Resource
            Center National Institute of Technology and Evaluation, NITE
            Biological Resource Center; 2-49-10 Nishihara, Shibuya-ku, Tokyo
            151-0066, Japan URL :https://www.nite.go.jp/nbrc/index.html
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu v. 1.4
            Genome Coverage                   :: 168x
            Sequencing Technology             :: SMRT cell 8 Pac V3
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018324205.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 05:20:17
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 9,101
            CDSs (total)                      :: 8,999
            Genes (coding)                    :: 8,910
            CDSs (with protein)               :: 8,910
            Genes (RNA)                       :: 102
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 81
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 89
            CDSs (without protein)            :: 89
            Pseudo Genes (ambiguous residues) :: 0 of 89
            Pseudo Genes (frameshifted)       :: 16 of 89
            Pseudo Genes (incomplete)         :: 75 of 89
            Pseudo Genes (internal stop)      :: 7 of 89
            Pseudo Genes (multiple problems)  :: 7 of 89
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 01:15:39
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6231822
            Orig. end                         :: 6243607
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            AP023356.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Annotated using prokka 1.11 from http://www.vicbioinformatics.com.
            Annotated at DFAST https://dfast.nig.ac.jp/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..11785
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="9"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11785
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11785
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6785](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..6785)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            826..2118
                     /locus_tag="Aiant_RS28340"
                     /old_locus_tag="Aiant_57140"
     CDS             826..2118
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Aiant_RS28340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Aiant_57140"
                     /product="hypothetical protein"
                     /protein_id="WP_189336115.1"
                     /transl_table=11
                     /translation="MKRFLAGTLAGVTALTLTVGCAKQLQQLEPKLAIQKAAEKLAATG
                     KAGFTLKAGGSVDDLIALAKKESGTGEGAFTDEDADLLRKIYRSSFTVAWDKAGDGVAD
                     DKALINAVIDGVTGLEIRVVDQVAYVKAPVSDLAAKFGASAADIAEIRKEMGAAVPGVE
                     TLLDGGWVSVDAAGLKKLSEGSVGVAPSTDPAQNEKLAAEVQASAHNLIEGAEVVRDGK
                     DDTHLVVTTSTVKAYTEGKRLVEAMATIAGGPTSELLDKSLGSELDKPPADKPIVMDLW
                     VDDDGFKAFEINLLQFAEGSTGRATLRVDIASGADIAAPGDATKLDVAKIFEQIAGAGA
                     GVGGPGGPIGPGGGAETWAGLLGSQAMLLAVSDGKPAAHLKEAARKLTIPGVTVKVVRR
                     GVAEVTSAGGVACVTVPASTSGEPEVVAHAC"
     gene            2138..3295
                     /locus_tag="Aiant_RS28345"
                     /old_locus_tag="Aiant_57150"
     CDS             2138..3295
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020510756.1"
                     /locus_tag="Aiant_RS28345"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Aiant_57150"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_229831373.1"
                     /transl_table=11
                     /translation="MRINVIGAGIGGLTAALSLLDAGFDVHVHERASALTETGAGIQLS
                     PNATRVLHGLGLEKELALTAVRPLAFHQRRWDDGRTLQRAPLGDQVQARFGFPYYHMHR
                     ADLLALLAAAFPAERLHLGHRLTGITDHGSHVRAHFGDGGTDDADVLVGADGIHSRVRA
                     ELFGAENPRFTGCVAYRGLVPADRVRDLAIEVSAQAWLGPGQHFVHYFVSGQRLLNFVA
                     VLERDAWTHESWTDRGDLADVLAAFDGWHPQVREIVTAADETYLWALFDRAPLERWSRG
                     RVTLLGDACHAMLPFLAQGAAQAVEDGATLARCLADGGDPAEALRRYETSRLARTSRVQ
                     AMSAANKTRFHLPDGPDQRDRDADLAAGATGWSFDAIAWLYEHRA"
     gene            complement(3427..4890)
                     /locus_tag="Aiant_RS28350"
                     /old_locus_tag="Aiant_57160"
     CDS             complement(3427..4890)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018586830.1"
                     /locus_tag="Aiant_RS28350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Aiant_57160"
                     /product="NF041680 family putative transposase"
                     /protein_id="WP_212846531.1"
                     /transl_table=11
                     /translation="MISVHDAVPADAVGQLTAFRQEFHRCLSRRPDALFELVDALLCGD
                     GPVISLPELSLTGEHRRSHGSLYAALSRGRIDVDRLRTALASVTVPRAADGRIVLAVDV
                     TCWLRPEAHTSPQRVLCHTYGRGKDTHIMVPGWPYSLVTALETGRSSWTAPLDARRLAP
                     GDDTATITAGQLRDVVERLIAAGHWQPGDPDIWIVADAGYDGPRLAFLLTDLPVQILVR
                     MRSDRVLRRPAPARTPGTTGRPPRHGGEFLFGDPASWGEPDAATTTDTRLYGAATARAW
                     HRLHPRLTHRTAWISQNGQLPIIEGTVIRLSVEQLPSGGNPKPVWLWWSHPTADSHEVN
                     LAWQAFLRRFDIEHTFRMLKQTLGWTRPKLRDPEAADRWAWLVLAAYTQLRLARAAVSD
                     LRRPWERPMPAERLTPARVRRGFRNLHSRTGSPTAAPKPSRPGPGRPPGRRNNQPATRH
                     DVHIVTSPNTSPSDKTKRISSRPRPRRTG"
     gene            complement(5001..6785)
                     /locus_tag="Aiant_RS28355"
                     /old_locus_tag="Aiant_57170"
     CDS             complement(5001..6785)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020514858.1"
                     /locus_tag="Aiant_RS28355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Aiant_57170"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_229831033.1"
                     /sec_met_domain="TIGR03975 (E-value: 3.9e-181, bitscore:
                     602.5, seeds: 14, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2e-14, bitscore: 53.4,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVAMPFMSVDRPSIQLGLLRAIGTAHGFPVDTLHANLDFAARVG
                     TDFYRSVADARGPLLGDWLFAPAAFGAAAPDPDGRFLDELGITGARRDRLLRARERDVP
                     ALLDDLAAGYPWAGVEVAGFTCTFQQNVASFALARRLKADHPGLVTIFGGAGFDDEMGL
                     ELLRRVDVIDLIVAGEADTAFPAVLRALSEGAEPAAVPGIARRAGSGLKVTAPAPPQED
                     LDALPPPDYREYFARAERLGLLSPAERREVWLPFESSRGCWWGAKHHCTFCGLNATTMS
                     YRSKSPQRILAELDTLSRRHRTLRFEAVDNILDMRHLTELFPAIADGRHDYEFFYEAKA
                     NLTREQLRALARGGVTRLQPGLESLSSTVLRLMNKGVRAAQNVNLLRWAGYYGLDVAWS
                     ILWGFPGETAGDYAEQTALIPHLAHLQPPEGSGRIWLERFSPLFTSIEKKTPTPSYRYV
                     YPTGFDHARLAYFFDDASGDALPDHVYAPLSDALDAWSRAWSREPRPALTYRAAPGVVQ
                     IHDTRHPESAGTYTFDGAIADVYLSCVDRPTGVAAIHRRLGRPGFVDEVLAEFARRGLI
                     FRDGSLVVALATPAVPGR"
     gene            complement(6809..7057)
                     /locus_tag="Aiant_RS28360"
                     /old_locus_tag="Aiant_57180"
     CDS             complement(6809..7057)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Aiant_RS28360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Aiant_57180"
                     /product="hypothetical protein"
                     /protein_id="WP_189334677.1"
                     /transl_table=11
                     /translation="MDEVVVNREDIDALAEAVEQGDLPAPELLRALVTAIRESVGEDFR
                     VSVSVEVDSVDDQFEASFAPEPSADRTVRVTVMKIGR"
     gene            complement(7068..9827)
                     /locus_tag="Aiant_RS46625"
                     /old_locus_tag="Aiant_57190"
     CDS             complement(7068..9827)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013124.4"
                     /locus_tag="Aiant_RS46625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="Aiant_57190"
                     /product="BTAD domain-containing putative transcriptional
                     regulator"
                     /protein_id="WP_189334678.1"
                     /transl_table=11
                     /translation="MDVRLLGEVQLLAAGRPLDTGTPRQQAVFAALAVDPGRPVPIETL
                     VDRVWGDDPPAEARNVLYSHISRIRGLLRQAAVLGDDAAGRLDRRHAGYVLDVDPDLVD
                     LHRFGRLTDQGRDPDRPEADRAAVLAQALSLWRGAPLAALTGDWAAGVRQAWHQRRLDT
                     VVAWARAELRLGHADAVIAAAPPLIAEYPLAEPLEALLMEALHRTGRDAEAMDRYAAVR
                     TRLAEALGADPGPQLRALHEAILRGEAHAPPPVRPVPVPAQLPPDVYGFAGRTAQLREL
                     EAVRATTPARPVAIDGMAGIGKTALAVHWAHRAARHFPGGQLYVNLRGFDATGDPVPPA
                     EALRGFLDALDVPPERVPAGLEARAGLFRSLLAGRRVLLLLDNARDAEQVRPLLPGAPG
                     CLAVVTSRNRLAGLVTTAGAHPLALGLPPAGEARDLLAYRIGVRRVAAEPDAVDEIVTR
                     CARLPLALAIVATRAAVAPELPLAALAGELREAQGGLTEFTDPDLESNVRAVFSWSYRQ
                     LGPAAAELFRRLAGHPGPDLGAPAAAALAGVPVTAVRPALDELTRAHLLERAGVRYTLH
                     DLLRAYATELAGTLDPAPERAAAARRVLGYYVHSAYAADLLLNPLRDEPVAAPPPLPAG
                     TVAERPAGQPEARAWFGAEYHVMLAALGGAADDEMAWQLAWALTRYLSYHGRWHDSIEA
                     LSAALAAARRRGEPAEAAFAHRYLGCAYVRLRRLDEAGTHLAEALRLHRAAGDVTGQAH
                     AHRHLAWLLEVQGRYREALGHAEQAVELFTAAGHRAGRGRGLNAIGWFHAMLGDYAEAV
                     TVCRAALRLQAEAGDRFGQAETWDSLGYATQRLGRHQEAIDAYRTAVALYQEFDDRYNE
                     ADSTASLGDAYHAAGDAAAARAAWRSAADLLDLIDHPGAAAIRARAGT"
     gene            9910..10635
                     /locus_tag="Aiant_RS28370"
                     /old_locus_tag="Aiant_57200"
     CDS             9910..10635
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="Aiant_RS28370"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="Aiant_57200"
                     /product="hypothetical protein"
                     /protein_id="WP_189334679.1"
                     /transl_table=11
                     /translation="MTDHHHHPSGECDTTGRHGMLLFGAGPVYLSHLPMYHCPHHFQVL
                     LEAELPPGVLEKVTGDGLFTFDPDPFPIAELGPHDGPARTTLTGTVFRGHFERGGTPIA
                     KGVRVTVRRVVWFRDIEDAAASGGGLPYLCFGRGEQVFLAHELTTRPNFDQVLAVRFVP
                     GTVRTQVGHPLDDDVAELRFDQAQPVTFGRDDGIDRRLHAGEVATGSFALTRSPSFSRG
                     FTVGVEVERELYLEIDELA"
     misc_feature    11349..11363
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 16.69"
                     /tool="antismash"
ORIGIN
        1 ccggtggcgg tggtgaccgc ggtgaggttc ggcgggttgc cccagccggt gtagtagtag
       61 ggcgcgacgg ccttgatgcc gggcccgccg gtggaggggg gtggggtggt gccgcccgag
      121 gagccgaagg tccacttctg gttggacgtg ccggtgcacg accagatctg gagcttcgcg
      181 ccgttcgcgg tgttcttgtc cttgacgtcc aggcacttgc cggacgcctg gttcaccagg
      241 tcgccggccg cgctcagcgt ccacttctga ctgctcacgg tgtcgtagca gtcccagagg
      301 tgcacggcgg cgccgtcggt ggtggcgttg ttcgccacgt ccaggcactt gcccctgccc
      361 tgcaccgagc cgttgtcggc aagggtccag agctggttgg cgctgccggc gacgcagtcc
      421 cagagctggg gcaggttgcc gttggcggtg gagccgtcgg tgacgtccag gcacttgccg
      481 ttcagggcgc tcttcagggt gccggcgctg gccgccgagg cggtgctgac gccgagggcg
      541 ccgagagtgc cgacgacgac cgcggaggtc acgatggcga ggatgcggga gcgtttcacg
      601 ggggatctcc cttgccgagg ggattggaaa ggtggcttac gattacgcct ccgtcgatgt
      661 gtcgtcaacc tcacgtgagt gtcacgaacg ccgcgttttc ccagctcaaa ggcggtagcg
      721 cgggcaacca taagggaacc ttaaaattcg ggaatccatg aaacacggca atgccggtcg
      781 atagggggtc gtacactccc gggcccaccc ttcgatcgga gacgcatgaa gcgcttcctg
      841 gccggcacgc tcgccggtgt caccgccctg accctcacgg tcgggtgtgc caagcagttg
      901 cagcagctcg agcccaagct ggcgatccag aaggcggcgg agaagctggc ggccaccggc
      961 aaggccggtt tcaccctcaa ggcgggcggc agcgtcgacg acctgatcgc gctggccaag
     1021 aaggagtccg gcaccggtga gggcgccttc accgacgagg acgccgacct gctccgcaag
     1081 atctaccgct cgtcgttcac ggtcgcctgg gacaaggcgg gtgacggcgt cgccgacgac
     1141 aaggccctga tcaacgcggt gatcgacggc gtgaccgggc tcgagatccg ggtggtcgac
     1201 caggtcgcct acgtgaaggc gccggtcagc gacctggccg cgaaattcgg cgcctcggcc
     1261 gccgacatcg ccgagatccg caaggagatg ggcgccgcgg tcccgggcgt cgagaccctg
     1321 ctcgacggcg gctgggtctc ggtcgacgcg gccggcctga agaagctcag cgagggcagc
     1381 gtcggggtcg cgccgagcac cgacccggcg cagaacgaga agctcgccgc cgaggtgcag
     1441 gccagcgcgc acaacctgat cgagggcgcc gaggtggtcc gcgacggcaa ggacgacacc
     1501 cacctggtcg tcaccacgtc cacggtcaag gcgtacaccg agggcaagcg cctggtcgag
     1561 gcgatggcga cgatcgccgg ggggccgacc tccgagctgc tcgacaagtc gctcggctcc
     1621 gagctggaca agccgccggc ggacaagccg atcgtcatgg acctgtgggt ggacgacgac
     1681 gggttcaagg cgttcgagat caacctgctc cagttcgccg agggcagcac cggtcgcgcg
     1741 accctgcgag tcgacatcgc ctcgggggcg gacatcgccg ctccgggcga cgccacgaaa
     1801 ctcgacgtcg cgaagatctt cgagcagatc gcgggcgccg gtgccggcgt cggcggcccg
     1861 ggtggcccga tcggcccggg cggcggggcg gagacctggg ccgggctgct cggctcgcag
     1921 gccatgctgc tcgcggtgag tgacggcaag ccggcggcgc acctcaagga ggccgcccgc
     1981 aagctgacca tcccgggcgt gaccgtgaag gtcgtgcggc gcggcgtcgc cgaggtcacc
     2041 tcggccggcg gcgtcgcgtg cgtgaccgtc ccggccagca cgtcgggcga gccggaggtc
     2101 gtcgcgcacg cctgctgaca tggcagaatc gcgagcgatg aggatcaatg tgatcggcgc
     2161 cggaatcggc ggcctgacgg cggcactgtc gctgttggac gccggtttcg acgtccatgt
     2221 gcacgagcgg gcgtccgcgc tgaccgagac cggcgcgggc atccagctca gtccgaacgc
     2281 gacccgcgtc ctgcacggcc tcggcctgga gaaggagctc gccctcaccg cggtgcgacc
     2341 gctcgcgttc caccagcgcc gctgggacga cggccgcacc ctgcaacgcg cgcccctggg
     2401 cgaccaggtc caggcccggt tcggttttcc gtactaccac atgcaccggg ccgacctgct
     2461 cgccttgctc gccgccgcgt tccccgccga gcggctccac ctgggccacc ggctgaccgg
     2521 gataaccgac cacggcagcc acgtgcgggc gcatttcggc gatggcggga ccgacgacgc
     2581 cgacgtgctg gtcggcgcgg acggcatcca ctcccgggtg cgcgccgagc tgttcggcgc
     2641 cgagaacccc cggttcaccg gctgcgtcgc gtaccgcggg ctggtccccg ccgaccgggt
     2701 gcgcgacctg gcgatcgagg tgtccgcgca ggcctggctc ggccccgggc agcacttcgt
     2761 gcattacttc gtcagcgggc agcggctgct caacttcgtc gcggtgctcg agcgggacgc
     2821 ctggacgcac gagtcgtgga ccgaccgcgg cgacctggcc gacgtgctgg ccgcgttcga
     2881 cgggtggcat ccgcaggtgc gggagatcgt gacggccgcc gacgagacgt atctctgggc
     2941 gctgttcgac cgggcgccgc tggagcgctg gtcgcggggc cgggtgacgc tgctcggcga
     3001 cgcctgccac gccatgctgc cgttcctggc gcagggcgcc gcgcaggccg tcgaggacgg
     3061 tgccacgctg gcccgctgcc tcgccgacgg tggtgatccg gccgaggcgt tgcggcgcta
     3121 cgagacgtcg cgcctggccc ggaccagccg ggtgcaggcc atgtcggcgg cgaacaagac
     3181 gcggttccac ctgcccgacg gcccggacca gcgggaccgg gacgcggacc tggcggcggg
     3241 cgcgaccggc tggtcgttcg acgcgatcgc ctggctctac gagcaccggg cttaaggcct
     3301 gtttcataac ccggccgagt gcgaggcgag gtcaggagtg tggctggcaa cggcggacgc
     3361 tgccaggcgc gctcctggcc acgccgcagc cccggtcggg ttatgaaaca ggccttaact
     3421 tgagttttaa ccggtgcggc gtggtctggg tctgctcgag attctcttcg tcttgtcgct
     3481 tgggctggtg tttgggctgg tgacgatgtg gacgtcgtgg cgggtggccg gctggttgtt
     3541 gcggcggccg ggtgggcgtc cggggcctgg ccgggagggt ttcggtgcag cagtaggact
     3601 gccggtcctg ctgtgcaggt tccgaaaccc gcgccggacg cgggcgggcg tgagccgttc
     3661 ggcaggcatg ggtcgttccc aggggcggcg taggtcgctg accgctgctc gggcgagtcg
     3721 cagttgggtg taggccgcca gcacgagcca ggcccagcgg tcggcggcct cggggtcgcg
     3781 tagttttggg cgggtccagc cgagggtctg tttgagcatg cggaaggtgt gctcgatgtc
     3841 gaacctgcgg aggaatgcct gccaggccag gttgacttcg tggctgtcgg cggtggggtg
     3901 ggaccaccag agccagaccg gtttcgggtt gccgccggac ggcagttgtt cgacgctcag
     3961 tctgatgacg gtgccctcga tgatcggtag ctgcccgttt tggctgatcc aggcggtgcg
     4021 gtgagtcaga cgcggatgca gccggtgcca ggctcgggcg gtcgcggcgc cgtagaggcg
     4081 ggtgtcggtc gtggtagccg cgtcgggctc gccccagctg gcagggtcgc cgaagaggaa
     4141 ctcgccgccg tggcggggcg gacggccggt cgtgcctggc gtccgggctg gtgcgggccg
     4201 gcgcaggact cggtcggagc gcatcctgac caggatctgc acgggcaggt cggtgagcag
     4261 gaacgccagt cggggtccgt cgtagccggc gtcggcgacg atccagatgt cggggtcgcc
     4321 gggctgccag tgtccggcgg cgatgagccg ttcgaccacg tcgcggagtt gcccggcggt
     4381 gatcgtggca gtgtcgtcgc cgggtgccag gcggcgggcg tccaggggtg cggtccacga
     4441 gctgcggccg gtctccaggg cggtgaccag tgagtatggc cagcccggga ccatgatgtg
     4501 ggtgtccttg ccgcggccgt aggtgtggca gagcacccgt tgcgggctgg tgtgggcctc
     4561 gggtcgcagc cagcaggtca cgtccacggc caggacgatc cgtccgtcag cggctctcgg
     4621 gacggtgacc gaggccaagg cggtccgtag ccggtcgacg tcgatacggc cgcggctcag
     4681 ggccgcgtac agcgaaccat gactgcgccg atgttcaccg gtcagtgaca gctcgggcag
     4741 cgagatcacc gggccgtccc cgcacaacag cgcgtccacc agctcgaaca aagcatccgg
     4801 acggcggctc aggcagcggt ggaactcctg cctaaacgcg gtcagctgcc cgaccgcgtc
     4861 agccggaaca gcgtcgtgca cactgatcaa cagacagccc ttgattcggt tttcttccct
     4921 agacaagaag atcatcaatc aagggctgtc tccatgatca gccagggtcg ataccgccag
     4981 gccgcacgtt aaaactcaag ttaacggccg ggcaccgccg gggtcgccag ggcgaccacc
     5041 agggacccgt cccggaagat cagcccgcgc cgggcgaact cggcgagcac ctcgtccacg
     5101 aagccgggcc ggcccagtcg ccggtggatc gccgcgaccc cggtcggccg atccacacag
     5161 gacaggtaca cgtcggcgat cgcgccgtcg aaggtgtagg tgcccgcgct ctccgggtgc
     5221 cgggtgtcgt ggatctgcac cacgcccggc gccgcccgat aggtgagcgc cggccgcggc
     5281 tcccgcgacc aggcccgcga ccaggcgtcg agcgcgtcgc tcagcggggc gtagacgtgg
     5341 tccggcaggg cgtcaccgga ggcgtcgtcg aagaagtagg ccagccgggc gtggtcgaaa
     5401 ccggtcgggt acacgtaccg ataactgggg gtgggtgtct tcttctcgat gctcgtgaag
     5461 agcgggctga agcgctccag ccagatgcgg ccggatccct cgggtggttg caggtgcgcc
     5521 aggtgcggga tcagggccgt ctgctccgcg tagtcgccgg cggtctcgcc cgggaagccc
     5581 cacaggatgc tccacgccac atccaacccg tagtaaccgg cccagcggag caggttcacg
     5641 ttctgtgcgg cccgcacgcc cttgttcatc agccgcagca ccgttgagct cagcgattcc
     5701 aggccgggct gcaaccgggt caccccgccg cgggccagcg cgcgcagctg ctcccgggtc
     5761 aggttcgcct tggcctcgta gaagaactcg tagtcgtgcc gcccgtcggc gatcgccggg
     5821 aacagctcgg tgagatgccg catgtcgagg atgttgtcga ccgcctcgaa acgcagcgtc
     5881 cggtgccggc gcgacagggt gtcgagttcg gcgaggatcc gctgcggtga cttgctgcgg
     5941 taactcatcg tggtcgcgtt gaggccacag aacgtgcagt gatgcttggc gccccaccag
     6001 cagccgcggg agctctcgaa gggcagccag acttcgcggc gctcggccgg ggagagcagg
     6061 ccgaggcgct cggcgcgggc gaagtactcg cggtagtccg gtggcggaag agcgtcgaga
     6121 tcctcctgcg gaggagcggg cgcggtcact ttcagaccgc tgcccgcacg gcgggcgatt
     6181 cccggtacgg ccgcgggctc cgcaccctcg gacagcgccc gcagcacggc cgggaacgcc
     6241 gtgtccgcct ccccggccac gatcaggtcg atcacgtcga cccggcgcag cagctccagc
     6301 cccatctcgt cgtcgaaccc ggccccgccg aagatcgtga ccagccccgg gtggtccgcc
     6361 ttcagccgcc gcgccagcgc gaacgacgcg acgttctgct ggaacgtgca ggtgaacccg
     6421 gccacctcga ccccggccca gggatacccc gccgccaggt cgtcgagcag cgcgggaacg
     6481 tcccgctccc gggcccgcag cagccggtcc cgccgcgccc cggtgatccc cagctcgtcg
     6541 aggaaccggc cgtccgggtc gggcgccgcc gcgccgaacg ccgccggcgc gaacagccag
     6601 tcgccgagca gcggcccgcg cgcgtcggcg accgaccggt agaagtccgt gccgacgcgg
     6661 gccgcgaagt ccaggttggc gtgcagggtg tcgaccggga agccgtgcgc cgtgccgatc
     6721 gcccggagca gcccgagctg gatcgacggc cggtccacgc tcatgaacgg catggcgacc
     6781 agcacggtgc gcacggtgcg gcgggcggtc agcggccgat cttcatgacg gtgacccgga
     6841 cggtgcgatc cgcggacggc tccggggcga acgaggcctc gaactgatcg tccaccgagt
     6901 ccacctcgac gctcacgctg acccggaaat cctcgccgac cgactcgcgg atcgcggtga
     6961 ccagggcgcg cagcagttcc ggtgccggca gatcaccctg ttcgacggcc tcggcgagcg
     7021 cgtcgatgtc ctcccggttg acgactacct cgtccatgtc tctcctctca ggtgccggcc
     7081 cgggcgcgga tggccgccgc gcccggatgg tcgatcaggt cgagcaggtc cgcggcggat
     7141 cgccaggccg cgcgggccgc cgcggcgtca ccggccgcgt ggtacgcgtc gcccagcgag
     7201 gccgtgctgt ccgcctcgtt gtaccggtca tcgaactctt gatagagcgc caccgctgtc
     7261 cggtacgcgt cgatcgcctc ctgatgccgg cccagccgct gcgtggcgta tccgaggctg
     7321 tcccaggtct cggcctgccc gaaccggtcc ccggcctcgg cctgcaggcg cagcgccgcc
     7381 cggcacacgg tgaccgcctc ggcgtagtcg ccgagcatgg cgtggaacca gccgatcgcg
     7441 ttgagcccgc ggccccgccc ggcccggtgc ccggccgcgg tgaacagctc gacggcctgt
     7501 tccgcgtgcc ccagcgcctc ccggtaccgg ccctgcacct ccagcagcca ggccaggtgc
     7561 cggtgggcgt gcgcctgccc ggtgacgtcg cccgccgccc ggtggagccg cagcgcctcg
     7621 gccaggtgcg tgccggcctc gtccaaccgg cgcagccgca cgtaggcgca gcccaggtag
     7681 cggtgggcga acgcggcctc ggccggctcg ccccgccgcc gggcggccgc cagcgcggcg
     7741 gacagcgcct cgatcgagtc gtgccagcgc ccgtggtacg acaggtaccg ggtcagcgcc
     7801 caggccagct gccacgccat ctcgtcgtcc gcggccccgc ccagcgccgc gagcatcacg
     7861 tggtactcgg cgccgaacca ggcccgcgcc tccggctgcc cggccgggcg ttccgcgacg
     7921 gtcccggcgg gcagcggcgg cggcgcggcc accggctcgt cgcgcagcgg gttgagcagc
     7981 aggtcggcgg cgtacgcgct gtgcacgtag tagcccagca cccggcgtgc cgcggcggcc
     8041 cgctccggcg ccgggtcgag cgtgccggcc agctcggtgg cgtacgcccg gagcaggtcg
     8101 tgcagggtgt accggacccc ggcccgctcc agcaggtgcg cccgggtgag ctcgtccagc
     8161 gccggccgga cggcggtgac cggcaccccg gccagcgcgg ccgcggccgg cgccccgagg
     8221 tccgggccgg gatgcccggc cagccgccgg aacagctccg ccgccgccgg gccgagctgc
     8281 cggtacgacc aggagaagac ggcccggacg ttgctctcca ggtcggggtc ggtgaactcg
     8341 gtcagcccgc cctgcgcctc gcgcagctcc ccggcgagcg ccgcgagcgg cagctcgggc
     8401 gcgacggcgg cccgggtggc gacgatcgcc agggccagcg gcagccgcgc gcagcgggtg
     8461 acgatctcgt cgaccgcgtc cggctcggcg gccacccggc gcacgccgat ccggtacgcc
     8521 agcaggtccc gggcctcgcc ggccggcggc aggccgagcg ccagcgggtg cgcgccggcc
     8581 gtggtgacca gcccggcgag ccggttgcgg ctggtcacca cggcgaggca gccgggcgcg
     8641 ccgggcagca gcgggcggac ctgctcggcg tcccgggcgt tgtcgagcag cagcagcacc
     8701 cgccggccgg ccagcaggct gcggaacagc ccggcccggg cctccagccc ggccgggacc
     8761 cgctccggcg ggacgtcgag cgcgtcgagg aaaccgcgga gcgcctcggc cggcgggacc
     8821 gggtcgccgg tcgcgtcgaa gccgcgcagg ttgacgtaga gctggccgcc ggggaagtgc
     8881 cgggcggcgc ggtgcgccca gtgcacggcc agcgcggtct tgccgatgcc ggccatcccg
     8941 tcgatcgcca ccggccgggc cggcgtggtc gcccggaccg cctccagctc acgcaactgg
     9001 gcggtacgcc cggcgaagcc gtacacgtcc ggcggcagct gggccgggac gggcaccggc
     9061 cggaccggtg gcggggcgtg cgcctcgccg cgcaggatcg cctcgtgcag ggcgcgcagc
     9121 tgcgggcccg ggtcggcgcc gagtgcctcg gccagccggg tgcggaccgc ggcgtaccgg
     9181 tccatcgcct cggcgtcccg cccggtccgg tgcagcgcct ccatcagcag ggcttccagc
     9241 ggctcggcga gcggatactc ggcgatcagc gggggagcgg cggcgatcac cgcgtcggcg
     9301 tgcccgagcc gcagctcggc gcgggcccag gcgaccacgg tgtcgagccg gcgctggtgc
     9361 caggcctgcc ggacgccggc cgcccagtcg ccggtgagcg ccgccagcgg cgcgccgcgc
     9421 cacaggctca gcgcctgggc gagcacggcc gcccggtcgg cctccgggcg gtccgggtcc
     9481 cggccctggt cggtgagccg gccgaaccgg tgcaggtcga ccaggtccgg gtccacgtcg
     9541 aggacgtagc cggcgtgccg gcggtcgagc cgcccggcgg cgtcgtcgcc gagcaccgcg
     9601 gcctgccgga gcagcccgcg gatccggctg atgtgcgagt acaggacgtt gcgggcctcg
     9661 gccggcgggt cgtcgcccca gacccggtcg acgagcgtct cgatcggcac cggccggccg
     9721 gggtcgacgg cgagcgcggc gaacaccgcc tgctgccgcg gggtcccggt gtcgagcggc
     9781 cggcccgcgg cgagcagctg cacctccccg agcaaccgga cgtccatagt gcccccccgc
     9841 acccatgctt gcctgcgccg caaggtggcc gcaaggtacg tgagcaggac aggggacgac
     9901 cgttcgggca tgactgacca ccaccatcac ccgagcggcg agtgcgacac caccggccgc
     9961 cacggcatgc tgctgttcgg cgccggcccg gtctacctgt cgcacctgcc gatgtaccac
    10021 tgtccacacc acttccaggt cctgctcgag gcggaactgc cgcccggcgt cctggagaag
    10081 gtgaccggcg acggcctgtt caccttcgac cccgacccgt tcccgatcgc cgagctgggg
    10141 ccgcacgacg ggccggcccg gaccacgctg accgggacgg tgttccgtgg ccacttcgaa
    10201 cgcggcggca ccccgatcgc caagggcgtg cgggtcaccg tgcggcgcgt cgtctggttc
    10261 cgcgacatcg aggacgcggc ggcctccggc ggcgggttgc cgtacctctg cttcggccgc
    10321 ggcgagcagg tgttcctggc ccacgaactg accacccggc cgaatttcga ccaggtgctc
    10381 gcggtgcggt tcgtacccgg cacggtacgc acccaggtcg gccatccgct cgacgacgac
    10441 gtcgccgagc tgcgcttcga ccaggcgcag ccggtcacgt tcggccgcga cgacggcatc
    10501 gaccggcggc tgcacgccgg cgaggtcgcc accgggtcgt tcgcgctgac ccgatcgccc
    10561 agcttctccc gcggcttcac ggtcggcgtc gaggtggagc gggagctgta cctcgagatc
    10621 gacgaactgg cctgagaggc ggacgaccat gaccgagcaa gtaccggacg tggcgctgga
    10681 cccggcgaag cccgaggtca agccactgtt cgcgatctcc ccggcgctgc ccgagagcat
    10741 cgaggcgcag ctcaagccgg tgcggatcgc gctgaacgtg ccgccgtcgg cgtttccggc
    10801 gcggctcggc gggttcgccg gtccggcgga ttcgccgtac gccaggcgca agggcgcctt
    10861 cggctgcgcg gcccgcgggt tcggggcgac cggcgaccgc atctggttct tccggggcgg
    10921 caagtacctg cggtacttcg agaagccgga gcgccacgac gagacgtccg gctggctgcc
    10981 gatcgccggc aactggaacg tgccgccggc cttcgccaac cgggtcgacg cggtgctgac
    11041 cgggagcatc ccgccgtacc aggggcacgt ctggctgttc agcggcgacc agtacctgcg
    11101 ttacgacccg aacagcgaca ccgtgatcat cggggcccag ccgatcgccg ggaactggaa
    11161 cctgccgccg gagttctgtt ccggcttcga cgcggtgatc cacggcgccg gcccgttcct
    11221 cggcatcgtc tggttcttca agggcggcaa gtacgtccgc tacaacctgc gcgacgacgt
    11281 caccgagttc ggcccgtccg acatcacgcc gctgtggcgg gactggccgg aggccttcgc
    11341 cgacggggtg gacttcgcgt tctacggcac cgggccgcac gagaaccaca tctacttctt
    11401 ccgcggcgac cagttcatcc ggtacgacct ggacgccgac cgggtcgtgg agggccccgc
    11461 caaggcggtc gagagctggc ccgccctggg ccggtacatg ccggtcccgc agctcttcct
    11521 cgacgagcgg taccagctgt tcaccttcca cggccggctc ggcaacggcg gcgtggtcgg
    11581 cacccggacg atcgagggcc gcagccgcac cgaggtctgg gtgatcaccc gccgccagga
    11641 gaaggtcgac acgaagacct cgtcgaacct gctggagagc agctcgcagc aggtcgtcga
    11701 caacttctcc gagcaggtcc ggcacgacga ctcggagcag cagagccggg aggactacga
    11761 ctacggcacc gacgcctcgt tccac
//
