LOCUS       NZ_CP072646            20264 bp    DNA     circular CON 02-DEC-2024
DEFINITION  Chloracidobacterium sp. MS 40/45 chromosome 1, complete sequence.
ACCESSION   NZ_CP072646
VERSION     NZ_CP072646.1
KEYWORDS    RefSeq.
SOURCE      Chloracidobacterium sp. MS 40/45
  ORGANISM  Chloracidobacterium sp. MS 40/45
            Bacteria; Pseudomonadati; Acidobacteriota; Terriglobia;
            Terriglobales; Acidobacteriaceae; Chloracidobacterium;
            Chloracidobacterium aggregatum.
REFERENCE   1  (bases 1 to 2667443)
  AUTHORS   Saini,M.K., Costas,A.M.G., Tank,M. and Bryant,D.A.
  TITLE     Genomic and phenotypic characterization of Chloracidobacterium
            isolates provides evidence for multiple species
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2667443)
  AUTHORS   Saini,M.K., Costas,A.M.G., Tank,M. and Bryant,D.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2021) Department of Biological Sciences, Tokyo
            Metropolitan University, 1-1, Minami-Osawa, Hachioji, Tokyo 1920397,
            Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu 1.8 assembler v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018304805.1-RS_2024_12_02
            Annotation Date                   :: 12/02/2024 00:41:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,029
            CDSs (total)                      :: 2,976
            Genes (coding)                    :: 2,951
            CDSs (with protein)               :: 2,951
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 25
            CDSs (without protein)            :: 25
            Pseudo Genes (ambiguous residues) :: 0 of 25
            Pseudo Genes (frameshifted)       :: 7 of 25
            Pseudo Genes (incomplete)         :: 18 of 25
            Pseudo Genes (internal stop)      :: 2 of 25
            Pseudo Genes (multiple problems)  :: 2 of 25
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2347916
            Orig. end                         :: 2368180
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP072646.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20264
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="7"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..20264
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20264
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:10264](-)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..10264)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     gene            complement(368..1468)
                     /gene="glsA"
                     /locus_tag="J8C02_RS09820"
                     /old_locus_tag="J8C02_09820"
     CDS             complement(368..1468)
                     /EC_number="3.5.1.2"
                     /GO_function="GO:0004359 - glutaminase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="glsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100486.1"
                     /locus_tag="J8C02_RS09820"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09820"
                     /product="glutaminase A"
                     /protein_id="WP_211422007.1"
                     /transl_table=11
                     /translation="MSLQVNVSAEAVSVRQSAERLRILSVLNDLHLKYKSLQDGRVADY
                     IPQLAKVSPDLFGICIATVDGQIFEVGDYDYLFTIQSISKPFVYGLALEDHGRDYVRTR
                     VGVEPTGDAFNSIIKLDERSKRPHNPLVNAGAIAMTSIIKGTDPTDKLNRLLDLFQRYT
                     GHGIFADMSVFMSERTTGHRNRAIAHLMLNFGMIDGNVDEALDLYFQQCSLMVSCRDLA
                     VMGATLANRGVNPLTGERAIAAEYVRDILSVMFTCGLYDYAGEWAYRVGLPAKSGVGGG
                     LLAVVPGRFGIGVFSPLLDERGNSVRAIKVCEGIVQAFGAHIFDLAFTLPSSAAAHEVH
                     LEHPARTADARNGHTASHPPEPHRVA"
     misc_feature    1883..1896
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.27"
                     /tool="antismash"
     gene            2753..3526
                     /locus_tag="J8C02_RS09825"
                     /old_locus_tag="J8C02_09825"
     CDS             2753..3526
                     /EC_number="2.7.1.33"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100487.1"
                     /locus_tag="J8C02_RS09825"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09825"
                     /product="type III pantothenate kinase"
                     /protein_id="WP_211425802.1"
                     /transl_table=11
                     /translation="MLLVIDVGNTNTTLGVYAGEALIAHWRLTTERERTIDEYGILCRN
                     LFTISQLDPRDITGIAIASVVPPLNFTFFRMAQTYFGREPFFVRPTENVGMPIRYDVPQ
                     DVGADRIVNAVAAYARHGGPCVVVDFGTATTFDAISEEGAYLGGVIAPGIVISAEALFQ
                     RAARLPRVSIAHPAQVIGASTIGSIQSGLYFGYIGLVEGILQRMQAEMGHLRAVIATGG
                     LARLIGKGSPLITEIDENLTLEGLRLIYQRNARTA"
     gene            3560..4069
                     /locus_tag="J8C02_RS09830"
                     /old_locus_tag="J8C02_09830"
     CDS             3560..4069
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100488.1"
                     /locus_tag="J8C02_RS09830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09830"
                     /product="asparaginase"
                     /protein_id="WP_211425803.1"
                     /transl_table=11
                     /translation="MSPTSLPLRILLTGGTLDKVYDERTGSLVFSRTHLFDMLDQARCY
                     LANITIEPVMLKDSLDLTEADRSIICAAVARAPENHIIVTHGTDTMTETAHVVAAQVTE
                     KTVVFVGAMIPYSFGGSDALFNLGFALASARTLPPGVYIAMNGTVFDWRNVRKNRERGR
                     FEPLHP"
     gene            complement(4131..4544)
                     /locus_tag="J8C02_RS09835"
                     /old_locus_tag="J8C02_09835"
     CDS             complement(4131..4544)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS09835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_09835"
                     /product="hypothetical protein"
                     /protein_id="WP_211425804.1"
                     /transl_table=11
                     /translation="MEVRQLTKHQEHVVRHVFGCQILGVYAQHEHLHFLLDIPYLWSVD
                     ADGSMALVQDEEAIAALDLPEDTRRALYGEAAALREQGPAATVRHFMPPPQAIGAIEDV
                     TLYTVGDTTHMQVIGDADTLTGVWSGASIHLLT"
     gene            4556..6799
                     /locus_tag="J8C02_RS09840"
                     /old_locus_tag="J8C02_09840"
     CDS             4556..6799
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF023418.5"
                     /locus_tag="J8C02_RS09840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09840"
                     /product="DUF3488 and transglutaminase-like
                     domain-containing protein"
                     /protein_id="WP_211425805.1"
                     /transl_table=11
                     /translation="MNIEQFFKAASYALVTGGFLTLALTGRVDVATCILYSLALIASWF
                     ADRPGLRLQISERVANWCVVGYAPFAYLDFRYLSSSWITALIHFVLFVSIFKLFQIKRD
                     RDWVFLYLLAVFEMLLAAGLTIDALFLLLLTVFTLTGLAALQAFEVVRTGRNLRQPLRT
                     VTLSYDGQQARRASRPVRYLLAMTFVMAALIGALSVPTFFLLPRWNTGLLSQTFSEDTA
                     MTGFSDLSIALGSVGNIKSDERTAMRVRVENPLPPHLHWRGMVMTQFDGREWTRPEANR
                     RVAVMRQNGGYILDERPKRSRPVVQTVYVEPMSTSALFHCGRPVAVSNLRGLALDSTGT
                     LYREERGTRLSYTVLSHLDETPVEQLRQDPLKYDAQTRATFLQLPATFDARVTQLAREI
                     TADATNGYDRARAIEQHLKTRCAYTLELQRGNEPDPIVDFLFETRRGHCEYFASAMALM
                     CRSLGLAARLAGGYHLGEYNDINNTYIVRQADAHAWVEVYFPQTETWVEFDPTPGAAPA
                     PPTAAAEWLASARRYIEALRMFYIDYVIAYDVQRQRGLAQDVGRAAARYQTSAEVYIYR
                     YRERLRMWTISQVIWIYSAVTGTELFYHLTVLLVLAGAMLLTLAGYLLWRRIRRQPRLL
                     FERRWLSWLAPLFRWTLRQDERQSAVLFYDEMAALLSRAGHRRAPHQTPLEFASATGFE
                     EVLTITRAYNQARYGERPDLDSRQIDRALQGLRQRLRQRRSGFWRTLWRPGRS"
     gene            complement(6811..8700)
                     /gene="mnmG"
                     /locus_tag="J8C02_RS09845"
                     /old_locus_tag="J8C02_09845"
     CDS             complement(6811..8700)
                     /GO_process="GO:0002098 - tRNA wobble uridine modification
                     [Evidence IEA]"
                     /GO_process="GO:0008033 - tRNA processing [Evidence IEA]"
                     /codon_start=1
                     /gene="mnmG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100491.1"
                     /locus_tag="J8C02_RS09845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09845"
                     /product="tRNA uridine-5-carboxymethylaminomethyl(34)
                     synthesis enzyme MnmG"
                     /protein_id="WP_211425806.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.1e-07, bitscore:
                     28.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPFNEVFDVIVIGAGHAGCEAAHAAAKLGCQTALITLNLDLIAQM
                     SCNPAIGGIAKGHLVREMDAVGGLMGRIIDRTGIQFRMLNRSRGPAVQSPRAQADRALY
                     RTEMRRFLETVENLHLRQGEVIDLMVEQERIIGVEMWDGRRLGASAVVICTGTFLNGLI
                     HIGTRTYQAGRAGELPSLLLAESFRRLGFRVGRLKTGTPPRVHAKTIDWSKCEEQPGDA
                     DPTPFSFGTKAITRRQLSCYITYTNEETHRVIRENLDKSPMYSGQIQSIGPRYCPSIED
                     KVVKFPDKQRHQVFLEPEGFETHEVYVNGISTSLPIEVQERLVRTIPGLEQAQLIRPGY
                     AIEYDMVDPTELKPTLETKRIRGLFHAGQINGTTGYEEAGCQGLIAGINAARLAKGLPP
                     VVLDRAGSYIGVLVDDLTTQGVDEPYRMFTSRSEVRLLLRIDNSDQRLTPLGHAIGMVS
                     EDDYQRFQQRQSRIQTCHTLLEACSIRPDSWEADALAAETGIVVREKQRLSTLARRPEV
                     TADHLAAALRRAGVTDFDEAELGVAVNNLKYEGYVRHHEATARKLSKAADVAIPANFEF
                     SRLPGLSREMADKFARIRPATLGQAARIPGVTPAALAILSLHLGSGKRVAHPA"
     gene            complement(8835..9953)
                     /locus_tag="J8C02_RS09850"
                     /old_locus_tag="J8C02_09850"
     CDS             complement(8835..9953)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF026257.5"
                     /locus_tag="J8C02_RS09850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09850"
                     /product="nucleotidyltransferase family protein"
                     /protein_id="WP_211425807.1"
                     /sec_met_domain="NTP_transf_5 (E-value: 3.5e-43, bitscore:
                     144.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTRYPDIMPHRDNGVVAERQLERLMACLPEREAALSDLAAEVTD
                     WAALLTSAQQHGLEDYLFRRLTRTGVPLPDVIREHFRLLQAHKAAWTLQLTAQMDRILD
                     ALQSAGIAAVPLKGPLLGERLYGADGFRSSSDLDVLVPYQQVHPALAAVAALGYQTDAA
                     TLEKALAGDHNIALDNISPPLELHFHLFRRFGVTLQAEDFLARAVPYRTQRGRLIQVLA
                     PEDEFLFLCVHAAAHSFARLAWLFDLKLLLHRHPAFDWETLCRRMHDWQVTTAVIFACE
                     LLRQRLRVETPLLACLTPGRRRWLHFNQRLFDQAMRRYNRPRRSLGAKLGFFLAAHLYQ
                     SSLHDRWPSRLRFLGLTVLRTLQRRQLAPGEA"
     gene            complement(10001..10264)
                     /locus_tag="J8C02_RS09855"
                     /old_locus_tag="J8C02_09855"
     CDS             complement(10001..10264)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="J8C02_RS09855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09855"
                     /product="PqqD family protein"
                     /protein_id="WP_211425808.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 7.3e-22,
                     bitscore: 74.3, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.3e-17, bitscore: 60.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNFRPHPSVVSTEVEEALVILHLDTKRYFTLNSTGAAIWHHLTQ
                     GKAEAEIVTALAAEYDADEAHLADSTRRLLAQLEAAALIERV"
     aSDomain        complement(10007..10258)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_J8C02_RS09855_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="9.30E-24"
                     /identifier="RREFam002.1"
                     /label="J8C02_RS09855"
                     /locus_tag="J8C02_RS09855"
                     /protein_end="86"
                     /protein_start="2"
                     /score="74.3"
                     /tool="antismash"
                     /translation="NFRPHPSVVSTEVEEALVILHLDTKRYFTLNSTGAAIWHHLTQGK
                     AEAEIVTALAAEYDADEAHLADSTRRLLAQLEAAALIER"
     gene            complement(10261..11307)
                     /locus_tag="J8C02_RS09860"
                     /old_locus_tag="J8C02_09860"
     CDS             complement(10261..11307)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="J8C02_RS09860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09860"
                     /product="radical SAM protein"
                     /protein_id="WP_211425809.1"
                     /sec_met_domain="PTHR43273 (E-value: 3e-31, bitscore:
                     105.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.7e-16, bitscore: 57.0,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 6.6e-07, bitscore: 26.7,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPEAALLDVLPVKRLTVGLTNLCNLDCDYCLRVAETQHLDFELLH
                     EVLRQARDYGVTAVTYTGGEVLLHPRFQDVLRRTAGLGLAYSFVTNGWHFPKAVPVLRE
                     TKTALYRIFFSLDGPTEAAHDAVRGKGSFRKLMAAMALCRFHGFPFGINMVVTKRSVGS
                     IEAMAVLGARLGADVVQFMHMLPTSEEYDRTLSLTPDERRAAEHEAMAVDAILRMPVQF
                     AAGHSMPVPGTPCVSLAGETVNLDCRGRLTLCCNLSDFRHAVGEADVIADMRVTSFQEA
                     CEQIHRLARFQRERRNAALAAGDATAEFPCHFCIATFDKTTWQGPALVQLGRARATDSK
                     PLPWSVPV"
     gene            complement(11300..12289)
                     /locus_tag="J8C02_RS09865"
                     /old_locus_tag="J8C02_09865"
     CDS             complement(11300..12289)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS09865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_09865"
                     /product="hypothetical protein"
                     /protein_id="WP_211425810.1"
                     /transl_table=11
                     /translation="MSASRGPSFGVLGQVSPSLQSVIETCRYLGLPETASETADIILTD
                     ERPAGGVRQLMPWLVWKGLTVHRQGSLLSITYGDWQVVLDVFRWRIIPIQIPLVADARA
                     SYEVFSYLRLVLLFLLRRLGWFELHGGACVQSGKGYVFTGPPGSGKTSAVLGLIESGWD
                     YVSDDALLVRQAPQPGAPAAVCLRAGRILFSVTGATLDRFPALQPHAERRWQRAGKWVV
                     NPSLLWPQRQVLSVQPAFLFFCQLREAEETQVLPLAATDALSHLMVNSPWLALDRETAA
                     AHLATYRKLAESCYSFTLLAGRDVWHEPSRLAAYLTATDLVRLHCDHA"
     gene            complement(12378..12533)
                     /locus_tag="J8C02_RS09870"
                     /old_locus_tag="J8C02_09870"
     CDS             complement(12378..12533)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS09870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_09870"
                     /product="hypothetical protein"
                     /protein_id="WP_211425811.1"
                     /transl_table=11
                     /translation="MNTLETKTVPTDSAPAKKVFVEPELKAFDQLEKQIQGLRVLEAFS
                     ASFLAP"
     gene            complement(12566..12967)
                     /locus_tag="J8C02_RS09875"
                     /old_locus_tag="J8C02_09875"
     CDS             complement(12566..12967)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF13471"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="J8C02_RS09875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09875"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_211425812.1"
                     /sec_met_domain="PF13471 (E-value: 5.4e-12, bitscore: 42.8,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVACLLWSGWLWLRVRWKTLPEVLDHLDRLPVRASAGSVPPEAIA
                     QTARAIVRRLPRFGVGECLLRSLVIYAMLRRQQRADISFVLGAGSLDSLGRPALHCWIE
                     VNGQPLLETNHLGERFRVMFRHRMPRLTT"
     gene            complement(13175..14392)
                     /locus_tag="J8C02_RS09880"
                     /old_locus_tag="J8C02_09880"
     CDS             complement(13175..14392)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp_3"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100492.1"
                     /locus_tag="J8C02_RS09880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09880"
                     /product="acetyl-CoA carboxylase biotin carboxylase subunit
                     family protein"
                     /protein_id="WP_211425813.1"
                     /sec_met_domain="ATP-grasp_3 (E-value: 6.5e-07, bitscore:
                     26.6, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNHERTVVCLASYFKGIEFLREVKRQGCRVVLVTKEKFRHEDWP
                     FESLDELIPLPNDATPELFIYTVAQLARPRKLHTVVALEELDVLTAALIREHLRLPGMG
                     STTARHFRDKLAMRIEAQQAGVRVPDFVHVLNYQDLEDYMKRIPPPWVMKPRSDVSAIG
                     IKKLYDSEQVWRTIDYLDARDRLSERSSNYVLERFVAGDVYHVDSLVENGEVVFAGVNR
                     YGRPPMSVAHDGGVFTTQTLPYDSPERAALSDINRKLITGLRMRRGATHAEFIKSAEDG
                     EFYFLEIASRVGGAYIAEALEAASGINIWAEWAKIELGRGEVPYVLPPTRQEYGGVALS
                     LARQEYPDTSSFTDPEIVYRVRKRYHIGLVVHSDRHERVTELLRDYTARFERDYCAVVP
                     PLERPE"
     gene            complement(14524..15471)
                     /locus_tag="J8C02_RS09885"
                     /old_locus_tag="J8C02_09885"
     CDS             complement(14524..15471)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS09885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_09885"
                     /product="hypothetical protein"
                     /protein_id="WP_211425814.1"
                     /transl_table=11
                     /translation="MRPGGKVCRLWLVGAGLVWLLWPETGALAQQVPPSPTVPPATATL
                     KAEGKTDDGRLFQEYVREQKMRFEYGRALKITLPPQGNLAITGSKRSELVVQATIRVEG
                     ASSAELAALAERIGFQFDTRDVRLHLMSLGPAVKNLSRKERRAVSEGLASPLLRLPYRI
                     DYTVAVPEYTDLEIAVFDGDLSLADIYGGIVFTVQRGRVVLSGVAGTVVGRLATGAARV
                     ELNGRSWRGSGLDLQVGVGDIVLSVPRGFAADVTLAASTPLDVRYPLNREADVPPDSPF
                     GLRTHGRFGVGGAALQLMTGRGTLRVEPYPPEHP"
     gene            complement(15468..16589)
                     /gene="carA"
                     /locus_tag="J8C02_RS09890"
                     /old_locus_tag="J8C02_09890"
     CDS             complement(15468..16589)
                     /EC_number="6.3.5.5"
                     /GO_function="GO:0004088 - carbamoyl-phosphate synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006207 - 'de novo' pyrimidine nucleobase
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0006541 - glutamine metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="carA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1249: carbamoyl phosphate synthase small subunit"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100494.1"
                     /locus_tag="J8C02_RS09890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09890"
                     /product="glutamine-hydrolyzing carbamoyl-phosphate
                     synthase small subunit"
                     /protein_id="WP_211425815.1"
                     /transl_table=11
                     /translation="MEAILALEDGRLFYGRSIGAAGETTGEVVFNTAMTGYQEVLTDPS
                     YAGQLVTMTCPHIGNYGVNPEDVESRQPFVAGFIVRELSSVVSNWRATESLAHYLNRHG
                     IVGIEGIDTRALVRHIRERGAMRGVISTVEREASRLVAKAVSAPGMVGAALAKTVTCAA
                     PYTWPLAAAEDSTEYQRRRWHVVAYDFGVKFNILRHLAALGCRITVVPATTTSEEVLRL
                     QPDGVFLSNGPGDPEPLADIAREVRLLAERLPTFGICLGHQVLALAFGGKTFKLKYGHR
                     GANHPVRNLATGKVEITSQNHGFAVDPESLPEELEVTHINLNDGTLEGFRHRHLPVFCV
                     QYHPEAAPGPHDAAYLFEAFTALLPSRPAEVAA"
     gene            complement(16591..17346)
                     /locus_tag="J8C02_RS09895"
                     /old_locus_tag="J8C02_09895"
     CDS             complement(16591..17346)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015961.5"
                     /locus_tag="J8C02_RS09895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09895"
                     /product="lysophospholipid acyltransferase family protein"
                     /protein_id="WP_211425816.1"
                     /transl_table=11
                     /translation="MTRWWAGLATLVLRILGWTVRLDTSNLRDLPDPLHGHLPPATPII
                     YTFWHNQILAATLFFQRRGIVVMTSLSRDGDIIAEVIRRFGFGAARGSATRGSVTALKA
                     MVKAIRQGADAAFTIDGPKGPRYHAKEGAAMLASLSGAPIQPVCIVTEHHWTLNTWDAF
                     RVPRPFTVGHVFYGQPIWVRRGATAEDIAAATARLQAELDTLLHRWETEHPSQRRSSQR
                     RAGALPSDRHVLDSSPTAAAETASNVETD"
     gene            complement(17343..18737)
                     /gene="hisD"
                     /locus_tag="J8C02_RS09900"
                     /old_locus_tag="J8C02_09900"
     CDS             complement(17343..18737)
                     /EC_number="1.1.1.23"
                     /GO_function="GO:0004399 - histidinol dehydrogenase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100496.1"
                     /locus_tag="J8C02_RS09900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09900"
                     /product="histidinol dehydrogenase"
                     /protein_id="WP_211425817.1"
                     /transl_table=11
                     /translation="MQVFRLDEAAGQARLATILKRHTLVADPDVVRTVSDIIQLVRETG
                     DDGLFALTEKFDGVSLSAQNVRVEPALLEKLAGQVSAEVRTALRVAAGNIRHFHELQRE
                     YTRMMEQADGVQLVHRIQPLDAVGLYVPGGQAAYPSTVLMTAVPAQVAGVPRLVAVTPA
                     KSFLTQPVLAAALIEAGISEVYTVGGAQAIAALAYGTESIPRVAKIVGPGNRYVAEAKR
                     QVYGVVDVDAIAGPSEVVIIADDTADPVLVAADMLAQAEHDELAAAVCVTTSETLATAV
                     AEQLAYQAATLSRREVVEAALERFGAIFLVASLSEAVRLVNRMAPEHVEVMTSEPERLA
                     EDITFAGAVFIGAASAEAVGDYFAGPSHVLPTGGTARFFSPLGVYDFVRRTNLIRYTMG
                     RLIKTADMITCLAEAEGLDGHARSIRLRIDRHSGPLAPTTNPLTESKQNLLAVESPPET
                     TPDDEP"
     gene            complement(18748..19854)
                     /gene="tatC"
                     /locus_tag="J8C02_RS09905"
                     /old_locus_tag="J8C02_09905"
     CDS             complement(18748..19854)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_process="GO:0015628 - protein secretion by the type II
                     secretion system [Evidence IEA]"
                     /codon_start=1
                     /gene="tatC"
                     /inference="COORDINATES: protein motif:HMM:NF013097.5"
                     /locus_tag="J8C02_RS09905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_09905"
                     /product="twin-arginine translocase subunit TatC"
                     /protein_id="WP_211425818.1"
                     /transl_table=11
                     /translation="MADEPKIRPDEPFAEPPEEEEAAATMGFLDHLDELRRRVFYVVAF
                     IAIAFIVCWGFADVIYGFLSKPVAEALRASRLAQVRTSAPLPSLSELPDGAQVTYVFGA
                     GVAIDGLTVPPGTAVPARIARDAQGKRRLETAQTLVIQQRVVPEGFALPAAELLAAAPD
                     PLGQLVVHTVQGAFNLYIKVAFYAAIFFSIPFALYQLYAFVAPGLYRHERAYVYPVLVL
                     GTGFFLLGAAFGYYIAFPQACLFLLGTAKDFQPMIEVNEYFDLIITIVLGLGIVFELPT
                     VVFVLARLGLVTAGFLLRIWRLAVMIILVLAAIISPTSDIPNMMIFAVPMLALYFLSVG
                     IAYVFGRPREADESAPAAETGEELRSVG"
ORIGIN
        1 agagggttgg ttcctcgaaa aaggggtcaa tccagaaccg cgacgggtct ggaatgagca
       61 gcatgtcgct ttcgctgatg ttggcccagc cccgaatgct cgacgcatca aagccgaaac
      121 cttcggtaaa gctctcttcc gtcagttgcg agatagggaa ggaaatgtgt tgccacgagc
      181 cggggaggtc ggtgaaacgc aggtcaacga acttcacgcc ttcgtcattg gcgaagttca
      241 gtacggattt gggatccatg tggatacctt tcgcggtgaa agactcagca cgatatgcag
      301 cctgccgccg tgggggagca gcggccaggg ttcaaaaatc ttcaggccgg atggaaagtg
      361 gcacaggtca cgcaacacgg tgcggctccg gcggatggga tgccgtatga ccattgcgcg
      421 catcggctgt ccgggcgggg tgttccaggt ggacttcgtg ggcagccgcc gatgagggca
      481 gagtaaaggc cagatcaaag atatgtgcgc caaaggcctg cacaatccct tcgcaaacct
      541 tgatggcccg gacgctgttg ccacgttcgt cgagcagcgg cgagaacaca ccaatcccaa
      601 atcgccccgg aacgaccgcc agcagcccac cgccaacccc gcttttggcc ggcaggccca
      661 cgcgataggc ccattcgcca gcatagtcat acaaaccaca ggtgaacatg acactgagaa
      721 tgtcccggac atactcggca gcgatggcgc gttcgcccgt cagcggattg acgccccggt
      781 tggccagcgt agcgcccatc acggccagat cacggcagga gaccatcaac gaacactgct
      841 gaaagtataa atccagggcc tcgtccacgt tgccgtcaat cataccgaag ttgagcatca
      901 ggtgcgcaat ggcgcgattg cggtggccgg tcgtccgctc ggacataaac actgacatgt
      961 cggcaaagat gccgtggccc gtgtagcgtt ggaacagatc gagcaggcgg ttgagcttgt
     1021 cggtcgggtc ggttcccttg atgatgctcg tcatggcgat agcgccggca ttgacgagcg
     1081 ggttgtgcgg acgcttggaa cgctcatcga gcttgatgat ggagttgaag gcatcgcccg
     1141 tcggctcgac gcccacccgg gtccgaacat agtcacggcc gtggtcttcg agcgccagtc
     1201 catagacaaa gggctttgag atggactgga tggtgaacag gtagtcgtag tcccccacct
     1261 cgaagatttg cccatccacg gtggcgatgc agatgccgaa caggtccggc gacaccttgg
     1321 ccaactgcgg gatgtagtcg gctacccggc cgtcctgaag ggatttgtat ttcaggtgca
     1381 agtcgttgag aacagaaagg atacgcagcc gttcagcact ttggcgaacg gacacggctt
     1441 cggctgaaac gttgacttga aggctcatca gaaaactcca ctgagaacaa gaacataacc
     1501 ccggaccggt ttcaactcac ggagcagcgt cttgcctggc tcatcccctg ccgtgttggc
     1561 ggcgatggga ttcagcctgg ccccgtcctt cgcccaagct caatctaacg cataattcca
     1621 gtaccggcga aagcgtatcc catcccgcac cccggcgcat agcgacgccg ggaattgtcg
     1681 cgtaacgatc ccgtgggttg aaacccacgg ctaaattcat ccgtcgctac gcgacggtac
     1741 ataaggttca aacctacaat ggttttcaac ccacggtcgc ttgcccacac acacccatgc
     1801 gggcgggacg cccgcgctcc caggcccgtc gcatcagccg tggaccggaa atccgtggcc
     1861 gtggggtgtt ggtcgtgggt tgcaaccgca tgtttgccgc gtagcggcaa cggaattttg
     1921 ccgtgggttt caacccatgg aggtcagccc cacagaagag ttgagctggc gccccccgtc
     1981 gcgtagcgac gattgagttt agccgtgggt ttcaacccac ggatcatggt cgcccaccaa
     2041 tcgtccccgt cgcgtcagcg acggctgaac cccaccgtgg atgtcccgat tcgtggtgta
     2101 tccgtacgat ggcgcccgca ttcccgtgcg ggcgggaaat tgtgtcgttc gggggatatt
     2161 catccgtcgc tacgcgacgg ggggggtatg ggatgtcgtg atccgtgggt tgaaacccat
     2221 cgtgggtgaa cccacgatcc cgtgggttga aacccacggc taaattcatc cgtcgctacg
     2281 cgacgataca taaggttcaa acctacaatg ggtttcaacc cacggttggt tgcccacata
     2341 catgcgggcg ggacgcccgg gctcccaggc ccgtcgcgtc agcgacggat gaaatcaccg
     2401 ccctgccatc cttggggcca aacatcttgc cccacacccc gccttcacct atcgtcgcag
     2461 gtggtcgtcg tccgttctat gccgtacgtg ctgggcgcca gtgtttgggc cgatgccgtt
     2521 tgaacgggaa gctgcggtct tcacttcagg gcaagacgcc acgggcgccg tgcgatgaag
     2581 tgatgccagg ctacccacct gtccatgcag gttcaaacga tgcgccacga cggcggtggt
     2641 ggttggcgac gacccccttt ggcatctccc tgtacgccac cagggccgtc aggcggtacg
     2701 gacaggcgtc aggtgtgggg gccagccgac ttccccaccg ggtttcccag atatgctcct
     2761 cgtgattgac gttggtaata ccaacacgac gctgggcgtt tatgccggcg aagcgttgat
     2821 tgcccactgg cggctgacga ccgaacgtga gcgcaccata gacgagtacg gcattttgtg
     2881 ccgtaacctg tttaccattt cccagctcga tccgcgcgac atcaccggca ttgccatcgc
     2941 ctccgtcgtc ccgccactca acttcacctt tttccgcatg gcccagacgt acttcgggcg
     3001 cgagccattt ttcgtgcgcc cgacggaaaa cgtcggcatg cccatccggt acgatgtgcc
     3061 gcaggatgtc ggcgcagacc gcatcgtgaa tgctgtagcc gcatacgcgc gccacggcgg
     3121 gccatgtgtc gtcgtggact tcggcacggc gacgacgttc gatgccattt ccgaagaggg
     3181 ggcctatctg ggcggggtca ttgcgccggg catcgtcatc tcggccgaag ccctctttca
     3241 acgggcggcc cgcctgccac gggtgagcat cgcccacccg gcccaggtca ttggcgcctc
     3301 caccatcggc agcatccagt cgggactgta cttcggctat atcggcctcg tggaagggat
     3361 tttgcagcgc atgcaggcgg aaatgggtca cttgcgggcc gtcattgcca caggcgggtt
     3421 ggcacggctg atcggcaagg gttcgccgct catcaccgaa attgacgaaa acctgacgct
     3481 cgaaggcctg cgcctgattt accagcgcaa tgcccggacg gcttagcccg gcccggtttc
     3541 cagcaccttg tcatcctcta tgtcgccaac ttctctcccc ttgcgtattc tgctgaccgg
     3601 cggaacgctc gataaggtct atgacgagcg caccggaagc ctcgtctttt cccggacgca
     3661 cctgtttgac atgctcgatc aggcgcggtg ctatctggcc aacatcacga ttgagccggt
     3721 catgctcaag gacagcctgg acctaaccga agctgatcgg tccatcatct gcgccgccgt
     3781 ggcgcgcgca ccggaaaacc acatcatcgt gacgcacggg acggacacca tgaccgaaac
     3841 cgcccatgtg gtggccgccc aggtcacgga aaaaaccgtg gtgtttgtgg gagcgatgat
     3901 tccctattcc tttggcggtt cggatgccct gttcaacctg ggctttgccc tggcatccgc
     3961 ccggacgctg ccgccgggcg tctatatcgc catgaacggc acggtctttg attggcgcaa
     4021 tgtacgcaaa aaccgcgagc ggggacgctt cgagccgctt catccctgac gccatacggc
     4081 cctgacgcca cacatgggaa cggcacaagg tggctgtgac caccaccaac tcatgtcaga
     4141 aggtgaatgg atgccccgga ccagacgccg gtgagcgtgt ccgcatcccc gataacctgc
     4201 atgtgcgtgg tgtcgccgac ggtgtacagg gtcacatcct cgatcgcgcc aatcgcctgg
     4261 ggcggaggca tgaagtgccg gaccgtcgcc gccggcccct gctcgcgcag ggccgccgct
     4321 tccccgtaca gcgcccggcg ggtgtcttcc ggcaggtcca gcgcggcgat ggcttcttca
     4381 tcctgcacga gcgccatgct tccgtccgca tccacactcc acaggtaggg gatgtccaga
     4441 aggaaatgca ggtgttcatg ctgcgcataa acgcctagaa tctggcaacc aaacacatgc
     4501 ctgacgacgt gttcctggtg tttcgtaagc tgtcggactt ccatgattga cgcccatgaa
     4561 catcgagcag tttttcaagg cggcatccta tgccctggtt acgggtggct ttttgacgct
     4621 ggcgctcacc ggacgggtgg atgtggcgac gtgtatcctc tacagcctgg cgctcatcgc
     4681 aagctggttt gccgaccgtc cggggctgcg gctgcaaatc agcgaacggg ttgccaactg
     4741 gtgcgtcgtg ggatacgcgc cctttgccta ccttgatttc cgctatctca gcagttcgtg
     4801 gatcacggcg ctcattcact tcgtgctgtt tgtctcgatt ttcaagctct ttcagatcaa
     4861 gcgcgaccgt gactgggtgt ttctctacct gctggccgtg tttgagatgc tgcttgcggc
     4921 cggtctcacc attgatgccc tgttccttct gctgctcacg gttttcacgc tgaccggact
     4981 ggcggccctt caggcgtttg aagtggtgcg gacgggccgc aacctccgtc agcccctgcg
     5041 cacggtgacg ctgtcgtatg acggtcaaca ggcgcgtcgg gcaagtcgtc cggtacgcta
     5101 cctgctggcg atgaccttcg tcatggcggc gctcatcggg gccttgagtg tcccgacctt
     5161 cttcctgctg ccgcgctgga acacgggact gctgtcccag accttcagcg aagacacggc
     5221 gatgaccggc ttttctgacc tttccattgc gcttggctcg gtgggcaaca tcaaaagcga
     5281 cgagcgcaca gccatgcgcg tacgggttga aaacccgctg cccccccacc ttcactggcg
     5341 cggcatggtc atgacgcagt ttgatggcag ggaatggacg cggccggaag ccaaccggcg
     5401 cgtggccgtc atgcgacaga atggaggcta catcctcgat gagcggccga aacgcagccg
     5461 gccagtggtg cagaccgtgt atgtggaacc gatgagcacc agcgccctgt ttcactgtgg
     5521 ccgaccggtg gcggtgtcca atctgcgtgg cctggcgctg gattcgaccg gcacgctcta
     5581 ccgggaggaa cgggggacgc gcctgagcta caccgtgctg tcccacctgg atgaaacacc
     5641 ggtggagcag ttgcggcagg acccgctcaa gtatgacgcc cagacccgcg ccaccttcct
     5701 gcaactgccg gcgacgtttg atgcgcgggt gacgcagctc gcccgtgaga tcaccgccga
     5761 cgccaccaat ggctacgacc gggcgcgggc tattgagcag cacctcaaaa cgcgctgtgc
     5821 ctacacgctt gaactgcaac gggggaacga accggacccc atcgtggact ttctgttcga
     5881 gacgcgccgc ggccactgtg agtattttgc ttcggcgatg gcgctgatgt gccgttcgct
     5941 gggcctggct gcgcggctgg ccgggggcta tcaccttggc gagtacaacg acatcaacaa
     6001 cacctacatc gtccggcagg cagatgccca tgcctgggtc gaggtgtatt ttccgcagac
     6061 ggaaacctgg gtcgaattcg atcccacacc gggggcagcc cccgcccccc ccacggcagc
     6121 ggccgagtgg ctcgcttcgg cgaggcgcta catcgaggct ttgcgcatgt tctacattga
     6181 ctatgtcatt gcctacgatg tccagcgcca acgcgggctg gcgcaggatg tgggtcgtgc
     6241 ggccgcgcgg tatcagacat cggctgaagt ttacatctac cgctaccgcg agcggctcag
     6301 aatgtggacc atctcccagg tgatatggat ttactcggct gtgacgggta cggaactgtt
     6361 ctatcacctc acagtgttgc tggtgctggc gggcgccatg ttgctgacgc tggccggcta
     6421 cctgctctgg cggcgcatcc ggcgccaacc acgacttctc tttgaacggc ggtggttgag
     6481 ctggcttgcc cccctgttcc gctggacgct gcggcaggac gaacgccagt cggctgtcct
     6541 gttttacgat gagatggcgg cgctgctgag ccgcgccgga catcgccgcg cgccacatca
     6601 aacgccgctg gaatttgctt cggcaacggg cttcgaggaa gtcctcacca tcacgcgggc
     6661 ctacaaccag gcgcgctatg gcgaacggcc cgacctggac agccggcaga ttgaccgggc
     6721 actccaaggg ctgcgccagc gtttgcggca gcgccggtca gggttctggc gcacgctctg
     6781 gcggccgggg cgcagctaga cgcagcctgt tcaggcaggg tgggcgaccc gcttcccgct
     6841 tccaaggtga agactgagaa tggccagcgc cgccggcgtc acgcccggaa tccgcgcggc
     6901 ctgtcccagg gttgccggac ggatgcgcgc aaacttgtcg gccatttcac gcgacagccc
     6961 cggcaaccgc gaaaactcaa aatttgccgg aatggccaca tcggcggctt tcgacagctt
     7021 ccgcgccgtg gcctcgtggt gacgcacgta gccctcatac ttcaggttat tcacggccac
     7081 ccccagctcg gcctcgtcga aatccgtcac tccggcccgg cgcagggcgg ccgccagatg
     7141 gtccgccgtg acttccgggc gccgcgccag ggtggacaaa cgctgctttt cccgaacgac
     7201 gatcccggtc tcggcggcaa gggcatcggc ttcccatgag tccgggcgga tggagcaggc
     7261 ttcaagcagc gtgtggcagg tctggatacg tgactgtcgt tgctggaagc gctggtagtc
     7321 gtcttcgctg accattccga tggcgtggcc aagtggtgtc aggcgctggt cgctgttgtc
     7381 aatccgcagc aggagccgca cttcggagcg ggaggtaaac atccggtagg gttcatccac
     7441 gccctgggtc gtcagatcgt ccacgaggac gccaatgtaa ctgccggcgc ggtcaagcac
     7501 caccggcggg aggcccttgg ccagacgggc ggcattgatt ccggcgatca acccttggca
     7561 gccggcttcc tcataccccg tcgtgccgtt gatctgcccg gcatggaaca gtccccggat
     7621 gcgcttggtt tccagcgtcg gcttgagttc cgtggggtcc accatgtcgt attcgatggc
     7681 atagcccgga cggatgagtt gcgcctgttc gagaccggga atcgtgcgca cgaggcgttc
     7741 ctgcacctca attggcaggc tcgtcgaaat cccgttgaca tacacctcgt gggtttcaaa
     7801 gccttcgggt tcgagaaata cctggtggcg ctgtttgtcg ggaaacttca ccaccttgtc
     7861 ctcgatggac ggacagtagc ggggcccgat ggactgaatc tgcccgctgt acatgggtga
     7921 cttgtccagg ttctcccgga tcacccggtg ggtttcttcg ttggtatagg tgatgtagca
     7981 ggacagttga cggcgggtga tggctttcgt cccgaaggaa aagggggtgg gatcggcatc
     8041 gcccggctgc tcctcacact ttgaccagtc aatggttttg gcatggacgc gcggcggcgt
     8101 gccggttttg agccgtccca cgcgaaatcc gaggcggcgg aagctttcgg cgagcagcag
     8161 cgaaggcagt tccccggcgc ggccggcctg gtaggtgcgc gtaccgatgt gaatgagacc
     8221 gttgaggaac gtcccggtac agatgaccac ggctgacgcg ccgagccgcc ggccgtccca
     8281 catctcgacg ccgatgatgc gttcctgttc gaccatcaaa tcaatgacct cgccctgccg
     8341 caggtggagg ttttcgacgg tttcaaggaa gcgccgcatt tcggtccggt acagtgcgcg
     8401 gtcggcctgg gcgcgtggcg actgaacggc cggcccacgg cttcggttga gcatccgaaa
     8461 ctggattccg gtccggtcaa tgatcctgcc catcagcccg cccacagcgt ccatttcgcg
     8521 taccaggtgt cccttggcaa tgccgccgat ggcggggttg caggacatct gggcaatgag
     8581 gtcgaggttg agcgtgatga gcgccgtctg gcagccgagc ttggcggcgg cgtgggcggc
     8641 ctcgcatccg gcatgtccgg cgccgatgac aatgacatcg aaaacttcgt tgaacggcat
     8701 aatcctgggg cgcgggcatc ctgcccgccg gaacaacatg ggagtgcggg cagcctgccc
     8761 gcaggaaacc cgcatgaaaa cagaggggag tgtaccgagg ggccaaccgg actgacaacc
     8821 gcgcccggcg cgtctcatgc ctctccgggg gccagttgcc gtcgctggag ggtgcgcagc
     8881 acggtcagcc caagaaaccg caggcggctc ggccatcggt cgtgaaggct tgactggtag
     8941 aggtgtgccg ccagaaaaaa gccgagcttg gcgcccagcg agcgacgcgg acggttgtaa
     9001 cggcgcatgg cctggtcaaa aaggcgctgg ttgaagtgta gccaccggcg gcggccgggg
     9061 gtcaggcatg cgagcagggg tgtctccacg cgcaatcgct ggcgcagcaa ctcgcaggcg
     9121 aaaatgacgg cggtcgtcac ctgccagtcg tgcatgcgcc gacacagggt ttcccaatca
     9181 aaagcgggat gccggtgcag gagcagtttc aggtcaaaca accaggccag acgggcaaaa
     9241 ctgtgggccg ccgcatggac acacagaaag agaaattcgt cttccggggc cagcacctgg
     9301 atgagccgtc cacgctgcgt tcgatacggc acggcacgcg ccaggaaatc ctcggcctga
     9361 agcgtgacgc cgaagcgccg gaacaggtgg aagtgcagct ccagcggcgg cgaaatgttg
     9421 tcgagagcga tgttgtgatc gccggcgagc gccttttcca gcgtggccgc atcagtctgg
     9481 tagcccaggg ccgccacggc cgccagcgcc ggatgaacct gctggtaggg caccagcaca
     9541 tccaggtcac tggatgaccg aaaaccatcg gcgccgtaca gccgctcccc aagaagtggg
     9601 cctttgagcg gaacggccgc aatgccggca gactgcaagg catccagaat ccggtccatc
     9661 tgggctgtga gctggagcgt ccaggccgcc ttgtgtgcct gaagcaaccg aaagtgctcc
     9721 cggatgacat cgggcagcgg cacaccagtt cgggtgagcc gtcgaaacag atagtcttcc
     9781 agcccgtgct gctgggcgct cgtcaacagc gccgcccagt ccgtgacttc agcggccaga
     9841 tcggacaggg ccgcttcccg ctccggcaaa caggccatga ggcgttcaag ctggcgttcc
     9901 gcgacaacgc cgttgtcccg atgcggcatg atgtccgggt agcgtgtcgg catggcctgt
     9961 gcggtccata aaggtggcgg aagtcctctg gcaagtcccc ctagacccgc tcgataagcg
    10021 ccgccgcttc aagctgggca agcaaccgcc gggtgctgtc cgcaaggtgt gcctcgtcag
    10081 cgtcgtattc cgcagccagg gcggtgacaa tctccgcttc ggctttgccc tgggtgaggt
    10141 ggtgccagat ggcggcccct gtactgttga gcgtgaaata gcgcttcgta tcgaggtgca
    10201 ggatcaccag ggcctcttcc acttcggtgg agaccacgga gggatgcggc cgaaaattcg
    10261 tcataccggc acactccagg gcaatggttt ggagtccgtg gctcgcgccc gcccaagctg
    10321 cacgagcgcg ggcccctgcc aggttgtctt gtcaaacgtg gcgatgcaaa agtgacacgg
    10381 aaactcagcc gtagcgtctc cggcagccag cgccgcgttg cgacgttcac gctggaagcg
    10441 cgccagacgg tgaatctgct cgcaagcttc ctgaaaagaa gtcacgcgca tatcggcgat
    10501 gacatcggct tcgcccaccg catggcggaa gtctgacagg ttgcagcaca gcgtcaagcg
    10561 cccacgacaa tcgagattga ccgtctcccc ggcaagggac acacaggggg tgccgggaac
    10621 cggcatcgaa tgaccggcgg caaactgcac gggcatcctg agtatggcat ccacggccat
    10681 ggcttcatgc tcggccgccc gccgttcatc cggcgtcagg gacagcgtcc ggtcatattc
    10741 ctctgaagtc ggcagcatgt gcatgaactg cacgacatcg gccccaaggc gcgcgcccag
    10801 aacggccatg gcctcgatgc tcccgacgct gcgtttggtc acaaccatgt tgatgccaaa
    10861 gggaaagcca tggaaccggc acagggccat cgcagccatg agtttgcgaa acgatccctt
    10921 gccccggacg gcatcgtggg cggcttccgt cggcccgtcc aggctgaaaa aaatccggta
    10981 cagtgccgtt ttcgtttcgc gcagcaccgg cacagccttt ggaaagtgcc acccgttggt
    11041 gacgaacgag taagccaacc caagcccggc cgtgcggcgc agaacatcct gaaaacgcgg
    11101 atggagcagc acttccccgc ccgtgtaggt cacggccgtc acaccgtaat cccgcgcctg
    11161 tcgcagcacc tcatgcaaca gctcgaaatc cagatgctgt gtctcagcga cacgcaggca
    11221 gtagtcacaa tcgaggttgc acaggttggt caacccgacc gtgaggcgtt tgacaggcag
    11281 gacatccaaa agggcagctt caggcatggt cgcaatggag ccgaacaagg tcagtagccg
    11341 tcaaataggc agccagtcgc gagggttcat gccacacatc gcgcccggcc agcagcgtga
    11401 agctatagca cgactcagcc agcttacggt atgtcgccag gtgggccgca gcggtttcac
    11461 ggtcaagcgc cagccatggg ctgttcacca tcaaatggga cagggcatcg gttgccgcca
    11521 gcggcaggac ctgtgtttcc tcagcctccc ggagctggca gaaaaacaga aatgccggtt
    11581 ggactgacag cacctgccgc tgcggccaga gcagggacgg attgacaacc catttcccgg
    11641 cgcgttgcca gcgccgttcg gcatggggct gcaaagccgg gaaacggtcg agcgtcgcac
    11701 ctgtcacgga aaacaatatc cgcccggcac gcagacaaac cgcggcgggg gctccgggct
    11761 gcggcgcctg cctgacaagc agggcgtcgt cagaaacgta atcccagccg gactcgatga
    11821 gacccaaaac ggcactcgtt ttgccactcc ccggtgggcc ggtgaacacg taccctttcc
    11881 cggactggac acaggcgccg ccgtgcagct caaaccagcc aagccgccgg agcagaaaca
    11941 gcaggacgag tcgcagatac gaaaagactt cgtacgacgc cctggcgtcc gccaccaatg
    12001 gaatctgtat cgggatgatg cgccagcgaa aaacatccag cacaacctgc cagtccccgt
    12061 aggttatgct cagcaggctg ccttggcggt gaaccgtcag ccctttccac accagccatg
    12121 gcatcaactg gcggacgccc ccggctggtc gctcgtccgt caggatgatg tccgccgtct
    12181 cggaagctgt ctccggcagg ccaaggtagc ggcaggtttc aatgacggat tgcagcgacg
    12241 gggacacctg ccccaggaca ccaaatgaag gtccccggct tgcgctcatt cagtaaacct
    12301 ggagagccgg actgtctgga gagaaaacaa agggctggtc ccaacaacca gcccggtcat
    12361 aacctcaaga ggcaaactta tggggcaagg aagctggcac tgaaagcttc cagcacgcgc
    12421 aacccctgga tttgcttttc cagttgatcg aaggccttga gttcgggttc aacaaagacc
    12481 tttttggccg gcgccgaatc ggttggaacc gttttggttt caagtgtgtt catcgtatga
    12541 ctcctgaaaa tcttgggtta gggggttacg tggtcaacct gggcatccgg tgacgaaaca
    12601 tcacgcggaa gcgttccccc aggtggtttg tctccagcaa tggctgccca ttgacctcaa
    12661 tccagcaatg aagcgccgga cgcccaaggc tgtccaggga gccggcaccc aacacaaacg
    12721 aaatatctgc ccgctgttgc cgacgtagca tagcgtaaat caccagcgag cgcagcagac
    12781 actcgcccac accaaagcgc ggcaaacgac gtacgatggc gcgcgccgtc tgcgctattg
    12841 cctccggggg tacggacccc gccgaagcac gaaccggcag ccgatccaag tggtcaagca
    12901 cttccggcag ggtcttccat cgtacccgaa gccacagcca accggaccac agcagacagg
    12961 ccaccatcct gcccaaagga tgctgccgcc acacgaaaaa ggaaggcttt ccgacgtcaa
    13021 cccacaagat gcagcgaccg cttgatttat gcagatgtaa agggcttgcc cgcagccctc
    13081 accctacaca acctcaacca tcaggtgcaa gccttttttc gggcgcatgc gggtttcagg
    13141 acagtctgcc tcccgattcc cccctggctg gccgttactc cggccgctcc aggggcggca
    13201 cgacggcgca gtaatcccgc tcaaagcgtg ccgtgtagtc acgcagcagt tccgtcaccc
    13261 gctcgtggcg gtcagagtgc acgaccagcc cgatgtgata ccgcttcctg acgcggtaca
    13321 cgatttccgg gtcggtaaac gaggacgtgt ccgggtattc ctgacgcgcc agggaaaggg
    13381 caacgccacc gtattcctgg cgcgtcggcg gcaggacgta gggaacctcc ccacgcccca
    13441 gctcaatttt cgcccactcc gcccagatgt tgatcccgct tgcggcctca agcgcctcgg
    13501 caatgtaggc gccgcccacc cgactggcga tttccagaaa ataaaactca ccgtcttcgg
    13561 cactcttgat gaactcggca tgcgtggcac cgcgccgcat gcgcagcccg gtgatgagct
    13621 tgcggttgat gtcactgagt gccgcccgct ccgggctgtc gtagggcagg gtttgggtgg
    13681 taaagacccc accatcgtgc gcaacgctca tcggaggacg cccgtaccgg ttcaccccgg
    13741 caaagacgac ctctccgttt tcgaccagtg aatccacgtg atacacatcc ccggcaacga
    13801 atcgctccag gacatagttg ctcgaacgct cgctgaggcg gtcacgggca tccagatagt
    13861 caatcgtgcg ccagacctgc tcgctgtcgt agagcttctt gatgccaatg gcagagacat
    13921 ccgagcgcgg tttcatcacc cagggcggcg ggatgcgctt catgtagtct tccaggtcct
    13981 ggtagttgag cacgtgaacg aagtccggca cccgcacgcc agcctgctgc gcttcgatgc
    14041 gcatggcgag tttgtcgcgg aagtgccgcg ccgtcgtgct gcccatgccc ggcaggcgca
    14101 gatgttcccg gatgagcgcc gccgtcaaca cgtcgagttc ctccagcgcc acgaccgtgt
    14161 gcagcttgcg gggccgcgcc aactgcgcca cggtgtagat gaacaactcc ggcgtggcat
    14221 cgttgggcaa agggatcagc tcgtcgagac tttcaaacgg ccagtcctcg tggcgaaact
    14281 tctctttcgt caccaggacg acccggcacc cctggcgctt gacttcgcgc aggaattcga
    14341 tgcccttgaa ataactcgcc agacagacga cggttcgctc gtgattcgtc atgggtaggc
    14401 cctgaaacgc accttgaaga tgaaaaggca ggctgaaatg gcagcgtgtg accgcaagat
    14461 aacccgccag cccgatcact ggcaatcgcc aaccggacaa actgccggtg aatacggccg
    14521 gtgtcaggga tgctccgggg gatagggttc gacccggagc gtgccgcgcc ctgtcatcag
    14581 ttgtaacgcc gcgcccccca ccccaaaccg tccatgggtg cgcaacccaa aggggctgtc
    14641 cggtggaaca tccgcctcac ggttgagggg atagcgaaca tccagcggtg tgctggccgc
    14701 cagagtgaca tcagcagcaa agccacgcgg cacactcagc acaatatccc ctacccccac
    14761 ctgcaaatcc agccccgaac cgcgccagct tcgtccattg agttcgactc tggccgcacc
    14821 cgtcgccagt cgtccgacca ccgttccggc cacgccgctc agcacgaccc ggccgcgctg
    14881 cacggtaaac acgatgccgc cgtagatgtc agccaacgac agatcaccgt caaaaacggc
    14941 gatttccagg tccgtgtatt ccgggacggc taccgtatag tctatgcggt agggcaggcg
    15001 cagcagcgga ctggccagcc cttcggatac cgcgcggcgc tccttgcggg acaggttttt
    15061 gacagccgga cccagtgaca tgaggtgcaa acggacatcg cgggtgtcaa actgaaagcc
    15121 aatccgttcc gccagagccg ccaactcggc agatgacgcg ccttccacac gaatggtcgc
    15181 ctgaaccacg agttccgaac gcttgctgcc ggtaatcgcc agattgccct gcggcggcag
    15241 ggtgattttg agcgcccggc catactcgaa gcgcatcttc tgctcgcgga catattcctg
    15301 aaagagacgc ccgtcgtcag tttttccttc agccttgagc gtggcagtgg ccggcggcac
    15361 ggttggcgac ggcggcactt gttgcgccag tgcgcctgtt tcgggccaaa gaagccagac
    15421 cagaccagcg ccgaccagcc acagccggca gaccttcccg cccggcctca tgcggccacc
    15481 tcggccggac gactgggcaa cagcgccgta aacgcctcga acaggtacgc cgcatcgtgc
    15541 ggccccggcg cagcctccgg gtgatactgc acacagaaca ccggcaggtg gcgatggcgg
    15601 aaaccttcga gcgtaccgtc gttgagattg atatgggtca cttccagttc ctccggcagg
    15661 ctttccgggt caacggcaaa gccgtggttc tgcgaggtaa tttcaacttt gccggtggcc
    15721 aggttcctga ccggatggtt ggccccgcga tgtccatact tgagcttgaa ggttttgccc
    15781 ccaaacgcca gcgccaacac ctggtgccca agacagatgc caaaggtggg caggcgttcc
    15841 gccagcaggc gtacctcgcg ggcaatatcg gcgagtggct ccgggtcacc aggcccgttc
    15901 gagagaaata cgccatccgg ctgcaggcgc aacacctctt cggacgtggt ggttgccggc
    15961 acaaccgtga tgcggcagcc cagcgccgca agatggcgca ggatgttgaa cttgacaccg
    16021 aaatcatacg cgacgacatg ccaccgtcgt cgttggtact ccgtggagtc ttcagcggca
    16081 gccagcggcc acgtgtaggg tgccgcgcag gtcacggttt ttgccagagc cgccccaacc
    16141 atacccggcg cactgaccgc tttggccacc aggcgggatg cctcgcgctc aaccgtggag
    16201 atgacgccgc gcattgcccc ccgctcgcgg atgtgccgca ccagcgcccg cgtgtcaatc
    16261 ccctcgatgc cgacaatccc gtgccggttc agatagtgcg ccagcgactc cgtcgcccgc
    16321 cagttactga ccaccgacga cagttcccgc acgatgaaac cggccacgaa gggttgccgt
    16381 gactccacat cttcggggtt gacgccgtag ttgccaatgt gcggacaggt catcgtcacc
    16441 aactgtcccg cgtaggaagg gtcggtgagc acctcctggt agcccgtcat cgccgtgttg
    16501 aacacgactt cacccgttgt ctcaccggcg gcgccgatgc ttcttccgta aaacagacgc
    16561 ccgtcttcga gcgcgaggat ggcttccacg tcaatccgtc tccacgtttg aggctgtttc
    16621 cgccgcagcg gttggggatg agtctagcac gtgccggtca gagggcagcg cgcctgccct
    16681 gcgttgtgag gacctgcgtt gtgagggatg ttctgtttcc caccggtgca gcagggtgtc
    16741 cagctccgcc tgcaaccggg ccgttgcggc cgcaatgtct tccgccgtcg caccacgccg
    16801 gacccaaatc ggttgcccgt aaaacacatg cccgacggtg aagggcctgg ggacacggaa
    16861 ggcatcccag gtgttcagcg tccagtggtg ttccgtcacg atacagaccg gctggatcgg
    16921 cgcgccgctc aagctggcca gcatcgccgc cccctctttg gcgtggtagc gcggcccctt
    16981 ggggccgtca atggtgaagg ccgcatcggc tccctgccga atggctttga ccatggcttt
    17041 gagcgccgtc acactgcccc gcgtcgccga tccccgcgcc gccccaaagc cgaaacgacg
    17101 gataacctcg gcaatgatgt cgccatcgcg gctcagcgag gtcatcacca cgatgccgcg
    17161 ccgctgaaaa aacagcgtcg cagccagaat ctggttgtgc cagaaggtgt agatgatggg
    17221 cgtcgccgga ggcagatggc cgtgcagcgg gtcgggcagg tcgcgcaggt tggacgtatc
    17281 caggcgcacc gtccacccca gaatccgcag gacaagcgtt gccagtccgg cccaccaccg
    17341 tgtcatggct cgtcgtccgg ggtggtctcc ggcggtgact ccacggccag aaggttctgt
    17401 ttgctttcgg tcagcggatt ggtcgtcggg gccagggggc cgctgtggcg gtcaatccgc
    17461 aggcgaatcg agcgcgcatg cccgtccagc ccttcggcct cggccaggca cgtgatcatg
    17521 tcagccgttt tgatcagccg ccccatcgtg tagcggatga ggttcgtccg ccgcacaaag
    17581 tcatacacgc ccagcgggga gaaaaagcgc gccgtgccgc ccgtcggcag cacatgactc
    17641 ggcccggcaa agtagtcccc cacggcctca gccgaggcag cgccgatgaa aaccgcgccg
    17701 gcaaaggtga tgtcttcggc cagtcgctcc ggctcggatg tcatgacctc gacgtgttcc
    17761 ggcgccatcc ggttgacgag ccggacggcc tcggacagcg acgccaccag gaaaatcgcc
    17821 ccgaaccgct ccagcgccgc ctcgacgact tcccgccggg aaagggttgc cgcctgatag
    17881 gcaagctgct cggccacggc cgtggccagc gtttcgctcg tggtgacaca cacggccgcc
    17941 gccagctcgt catgctcggc ctgcgccagc atatcggccg ccaccagcac cgggtcggcc
    18001 gtatcgtcgg caatgatcac cacctcgctc ggtccggcaa tggcatccac gtccaccacg
    18061 ccgtacacct gccgtttggc ctcggctaca taccggttgc ccggcccgac aatcttggcc
    18121 acccgcggaa tgctttccgt gccgtatgcc agagccgcaa ttgcctgcgc accgccaacg
    18181 gtatagacct cgctgatacc ggcttcgatc agcgccgcgg ccagcaccgg ctgggtcaga
    18241 aaggacttgg ccggggtgac ggccaccagc cgggggacgc ctgcgacctg cgccgggacg
    18301 gccgtcatca gaaccgtcga gggataggcc gcctgtccac cgggaacgta gaggcccacc
    18361 gcatccagcg gctggatacg gtgaacgagc tggacgccat ccgcctgctc catcatccgc
    18421 gtgtattcgc gctggagttc gtggaagtgg cgaatgttgc cggcggccac ccgcagcgcc
    18481 gtccgtacct ccgctgacac ctgcccggcc agcttttcga gcagggccgg ttcgacacgc
    18541 acgttctgcg ccgacaggga tacgccgtca aacttctctg tcagcgcgaa caacccgtca
    18601 tcgcccgtct cccgtaccaa ctggatgatg tcggatacgg tacggaccac gtccgggtcg
    18661 gccaccagcg tgtggcgctt gagaatggtg gcgaggcggg cctgccccgc cgcctcatcg
    18721 agacgaaaaa cctgcataag ctttggacta tcctacggaa cgaagttctt cgccggtctc
    18781 tgcggccggg gcgctttcat ccgcttcacg cggccgtccg aacacataag caatccccac
    18841 actcaggaag tacagcgcca gcatcggaac ggcaaagatc atcatgttgg gaatatccga
    18901 ggttggcgag atgatagccg ccagaaccag gatgatcatc accgccagcc gccagatgcg
    18961 gagcagaaac ccggccgtca ccaacccaag acgcgccagc acaaagacga ctgttggtaa
    19021 ctcaaagaca atgcccaggc caagcacgat ggtgatgatg aggtcgaagt attcattgac
    19081 ttcaatcatc ggctggaagt ccttggccgt gcccagcaga aacagacacg cctggggaaa
    19141 ggcaatgtag tacccaaagg ccgcgccgag caggaaaaag ccggtcccca acaccagcac
    19201 cggatacaca taggcgcgct cgtggcggta gagtccgggc gcaacgaagg catagagctg
    19261 gtagagcgca aacgggatgg aaaagaaaat ggccgcgtaa aaggccacct tgatatacag
    19321 gttgaaagcg ccctgcacgg tatgcaccac caactgcccc agcggatcag gcgccgccgc
    19381 cagcagttcc gccgcgggca gggcaaagcc ctccggcaca acccgctgct ggataaccag
    19441 cgtctgggcg gtttccaggc gtcgttttcc ctgggcatcc cgcgcaattc gcgccggcac
    19501 ggccgttccc ggcggaacgg tcagcccatc aatggcgacg ccagcgccaa agacatacgt
    19561 cacctgggcg ccatcgggca gctcggagag gctgggcagt ggggcactgg ttctgacctg
    19621 cgccagccgc gaggcccgca gggcttccgc caccggcttg gacagaaagc catagatgac
    19681 atcggcaaag ccccagcaca cgatgaaggc gatggcgatg aacgccacga cgtagaacac
    19741 ccgccgccgg agttcgtcca gatggtcgag aaagcccatc gtggcggcag cttcctcttc
    19801 ttcaggtggc tcggcaaaag gctcgtccgg tctgattttc ggttcatcag ccatggcaaa
    19861 caccctggat acggcggcaa gcgcctgcgc gccggcctgc agacctagcc ttcatagcca
    19921 atggcctcga tggcttccac cgcccccgga cgggggacga acaccggacc gggaaacgcc
    19981 gcatctgccg gagcctccac aggcagggag gccgcagccg gagccgcggc cggggatgcc
    20041 agtggcgctt ccgccacctc caccgccggc aaggcctcgg cgagtgcctc agcgggcggc
    20101 agggctgacg atgctgccgc cgggcgggcg ggcgcgcggg acagggttcc ttcggccggc
    20161 acaaccccgg cctcggccgg ggacggagcg gcaaggtcaa ccgaaaggtc cggcagcttc
    20221 acgtccgaag acaaatcctt gaccagacgc gaccgctcgc tttc
//
