LOCUS       NZ_CP072646            10894 bp    DNA     circular CON 02-DEC-2024
DEFINITION  Chloracidobacterium sp. MS 40/45 chromosome 1, complete sequence.
ACCESSION   NZ_CP072646
VERSION     NZ_CP072646.1
KEYWORDS    RefSeq.
SOURCE      Chloracidobacterium sp. MS 40/45
  ORGANISM  Chloracidobacterium sp. MS 40/45
            Bacteria; Pseudomonadati; Acidobacteriota; Terriglobia;
            Terriglobales; Acidobacteriaceae; Chloracidobacterium;
            Chloracidobacterium aggregatum.
REFERENCE   1  (bases 1 to 2667443)
  AUTHORS   Saini,M.K., Costas,A.M.G., Tank,M. and Bryant,D.A.
  TITLE     Genomic and phenotypic characterization of Chloracidobacterium
            isolates provides evidence for multiple species
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2667443)
  AUTHORS   Saini,M.K., Costas,A.M.G., Tank,M. and Bryant,D.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2021) Department of Biological Sciences, Tokyo
            Metropolitan University, 1-1, Minami-Osawa, Hachioji, Tokyo 1920397,
            Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu 1.8 assembler v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018304805.1-RS_2024_12_02
            Annotation Date                   :: 12/02/2024 00:41:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,029
            CDSs (total)                      :: 2,976
            Genes (coding)                    :: 2,951
            CDSs (with protein)               :: 2,951
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 25
            CDSs (without protein)            :: 25
            Pseudo Genes (ambiguous residues) :: 0 of 25
            Pseudo Genes (frameshifted)       :: 7 of 25
            Pseudo Genes (incomplete)         :: 18 of 25
            Pseudo Genes (internal stop)      :: 2 of 25
            Pseudo Genes (multiple problems)  :: 2 of 25
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1856101
            Orig. end                         :: 1866995
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP072646.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..10894
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="6"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10894
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10894
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:5894](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..5894)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            complement(774..1361)
                     /gene="dcd"
                     /locus_tag="J8C02_RS07675"
                     /old_locus_tag="J8C02_07675"
     CDS             complement(774..1361)
                     /EC_number="3.5.4.13"
                     /GO_function="GO:0008829 - dCTP deaminase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006229 - dUTP biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="dcd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008063044.1"
                     /locus_tag="J8C02_RS07675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07675"
                     /product="dCTP deaminase"
                     /protein_id="WP_407062880.1"
                     /transl_table=11
                     /translation="MIKSDKWILRMCEEYNLISPFERRLIRHVEDRRIISCGLSSYGYD
                     CRLARDEFKVFSPIQGTEVDPKNFNPDNLLDIPLRTAADGSCYWLLPPHSYALGVTIEQ
                     FQMPRNVTAIALGKSTYARCGLIQNTTPLEADWKGRLVIELYNAANLPVRLYAEEGFVQ
                     IIFFESDEECAVSYSDRAGKYQHQTGLTLAKV"
     misc_feature    complement(1346..1360)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.72"
                     /tool="antismash"
     gene            1431..2636
                     /locus_tag="J8C02_RS07680"
                     /old_locus_tag="J8C02_07680"
     CDS             1431..2636
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS07680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_07680"
                     /product="hypothetical protein"
                     /protein_id="WP_211425439.1"
                     /transl_table=11
                     /translation="MAVHPIRLKLFLAVAGLMLLMSHALRTTSVARTGGAEPAPQRPRS
                     VEASENQTGPLSEVAFYRLVQRVRQGQIATDAAIRELRQRGIAFEVTDEVLDRARQLGA
                     PGALITALVELTFETGPPSPTARPKPTRTIPSGPTPATPGPSRDHEDMSGNEPPASSED
                     ETARLSQLPLIEQARFHALRSADDLPDFIVTQTIRRMVRDGRGQWQTRDTLETEVRVEG
                     GRERVELLSINGRTTQRRFEDVGGATSVGDFSGQLAAPFLPSTNTRFREAKRERYRGRV
                     CRVYDFVVPRANSGYTLTVRLSDGTPQRIQVGYQGSLWVDEDTKRVLRIEHTATDIPPG
                     FPMSQVESAVDYDWVTILGKNYWMPLTAETIQVSDAYRQAFRNVSEFRNYRKFEGDIKI
                     IE"
     gene            2741..3100
                     /locus_tag="J8C02_RS07685"
                     /old_locus_tag="J8C02_07685"
     CDS             2741..3100
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024865.5"
                     /locus_tag="J8C02_RS07685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07685"
                     /product="DUF4440 domain-containing protein"
                     /protein_id="WP_211425440.1"
                     /transl_table=11
                     /translation="MTAIRTLLDNQAAAWNRGDLEGFMDGYWRSPELTFVSGTTVTKGW
                     EATLARYRQRYQSEGRAMGTLDFQDLVIEMVGPRAALVRGAWRVVLPEQVASGRFTLLV
                     RRFSSGWRIVYDHTS"
     misc_feature    2760..2776
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 21.05"
                     /tool="antismash"
     gene            3237..4727
                     /locus_tag="J8C02_RS07690"
                     /old_locus_tag="J8C02_07690"
     CDS             3237..4727
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015094.5"
                     /locus_tag="J8C02_RS07690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07690"
                     /product="AarF/ABC1/UbiB kinase family protein"
                     /protein_id="WP_211425441.1"
                     /sec_met_domain="APH (E-value: 1.1e-06, bitscore: 25.7,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNRTLPADFSISPNVHPPVVPTQRGVWGWLRHWQRTLFIVWVLGR
                     FAWMLYRDLRRARAHSDGNLAALPTDRLEAQAARLREQLIRLGPTFIKIGQALATRADL
                     LPVPFIQELAKLQNRVPPFPNSEAFAIIEGELGAPISKLFRTVDPEPVAAASLGQVYRG
                     VRHDGQEVAIKVQRPNLVARISEDVDILRRLARWMASSKRLFKGNDWVGMIDEFERTIY
                     AELDYRNEGRNAERFRQNFADWPRVHVPTIFWEQTTSRVITMEFLRGICVTDLEGLAAA
                     GIDAREANELMYRTYFKQLLEDGFFHADPHPGNILMLHDGRLAFFDFGMVGHISPTLQS
                     QMVSAFFHLIERDAPGIVRDLVGLGFLSPEADMEAFARVVEDLFRRKLDVNLSEVRFKD
                     LTYDLGDIIYRYPFSTPASFTFIIRALMTLEGISITMNPRFNFLEVAMPYARDFLFRRE
                     SAQLREKVWASLHDARNGKLNWTRVWNLARTALALYFA"
     gene            complement(4715..5020)
                     /locus_tag="J8C02_RS07695"
                     /old_locus_tag="J8C02_07695"
     CDS             complement(4715..5020)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF038399.1"
                     /locus_tag="J8C02_RS07695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07695"
                     /product="Os1348 family NHLP clan protein"
                     /protein_id="WP_211425442.1"
                     /transl_table=11
                     /translation="MSSPHFEAFLARLYADEAFREQFLAAPENTACAFGLSPEECAALA
                     AIDLTGLELAARVFAKKLDYKAEYKRRQGWRTRWRRWWRDRWAEWRHRRRATFQAK"
     gene            complement(5001..5894)
                     /locus_tag="J8C02_RS07700"
                     /old_locus_tag="J8C02_07700"
     CDS             complement(5001..5894)
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF003818.1"
                     /locus_tag="J8C02_RS07700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07700"
                     /product="DUF692 family multinuclear iron-containing
                     protein"
                     /protein_id="WP_211425443.1"
                     /sec_met_domain="DUF692 (E-value: 1.6e-63, bitscore: 211.4,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEILPDRVGLGWRAPLAADILSNLDRIGVVEVIADDYFDAPRRE
                     RQALRWLGRQVPLVLHGVSLGLASTAPVDPVRLDHMARLIGEVEPWLWSEHLAFVRGGG
                     VEVGHLAAPPRTAATIEGTARNLAAARAVVGSDPLVENISTIIEPPGSALDEVSWLEGI
                     LAATENGLLLDLHNLYANACNFDFDPREAIARLPLERVGYIHLAGGKWVHATRFPGRRL
                     LDDHRHATPQPVFDLLAEVARRTAQPLVVILERDGDYPPFTELLDELDAARAALARGRA
                     DRNANRNVRTDVVATL"
     gene            complement(5963..7018)
                     /locus_tag="J8C02_RS07705"
                     /old_locus_tag="J8C02_07705"
     CDS             complement(5963..7018)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04222.1"
                     /locus_tag="J8C02_RS07705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07705"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_211425444.1"
                     /transl_table=11
                     /translation="MSSYPVSTPKPSDPWKSVTPTTNQATSPAGDDAWVVRSFIITWFT
                     LLLCFTVVIICLPKTAFLLAYLLACAGVITMLYVRRIVAEPVRELTKFDTSDPYRLAYL
                     RGGANEALRVATAVLIEARHLMLLQNESSEKKEKQLVTAPDCDAKSLPLPLERAVLRFF
                     TTPRKPEEMFGQGGLKQQVDDLYKEELEKAGLLPSEAQKQARTSRALFALIFILVVGLT
                     KMAVALWHGYSNIGFTVLIMIVAAIWAWNFSGDYRTRFGDYVIKSLESLFEGMRAQAAT
                     LKANASTAQIALLAGVYGVVALPADVFPEVREAFPRAPTDSSSCGSSCSSSCSSDGGSC
                     SSCGGGCGGCG"
     misc_feature    7159..7176
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 16.36"
                     /tool="antismash"
     misc_feature    complement(7167..7180)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            7427..9823
                     /gene="lon"
                     /locus_tag="J8C02_RS07710"
                     /old_locus_tag="J8C02_07710"
     CDS             7427..9823
                     /EC_number="3.4.21.53"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene="lon"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014100042.1"
                     /locus_tag="J8C02_RS07710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07710"
                     /product="endopeptidase La"
                     /protein_id="WP_211425445.1"
                     /transl_table=11
                     /translation="MTHELSDELPLTNEGTGDIPDTLPLLPLRDIVIFPFLIVPLFVQR
                     EKSQRAIENALPNRRLIVLATQRDPEHEDPTGDDLHRVGTIAAVMRLLKTGDGRVRILV
                     QGLARATLLRVTDEAGYMQAQVQAIPEASVEMTLEVEALVRAVKGLLERIVTLGKQISA
                     EVLAIAASLDDPGRLADLCASNLDAKISDAQAILEETDPIARLRRVHDLMAREVGILTV
                     QQEISSQAKGEIDRSQREFYLRQQLKAIQQELGEVSDAGDEVAAYQEKIAEARLPEPAR
                     EEATRQLKRLERLHPDAAEAGLLRTYLDTLLALPWNTFSEDHIDLQHVKAVLDADHYGL
                     EKVKERILEALAVRRLKPDTKGLLLCLVGPPGVGKTSLGRSVAKAIGRKFVHISLGGVH
                     DEAEIRGHRRTYVGALPGRIILGLQQAGTKNPLMLLDEVDKLGNDFRGDPASALLEVLD
                     PEQNHAFRDNYLGVPFDLSKVMFLLTANVTDTIQPALRDRLEIVRLPGYTQEEKLAIAR
                     RHLVPKQLAEGGLTGKHLSITESALRMTIARYTREAGVRQLEREIGKLCRKVARRVAEG
                     DSGKVTITAANLADYLGVPKFKADAILSQDRIGVAAGLAWTSVGGDVMHVEALLLRGKG
                     GLLLTGKLGEVMKESAHAALSYAKSRARELGIEPDVFTQHDLHIHVPEGAIPKDGPSAG
                     ITMATAMVSALSRRPVRRTVAMTGEITLRGDVLPVGGIREKILAARRAGIKTVILPAQN
                     QPDVGDIPAELVKGLKFIYVHEVSEVFAAALGKAAKTLPAKGVNK"
     gene            9820..10530
                     /locus_tag="J8C02_RS07715"
                     /old_locus_tag="J8C02_07715"
     CDS             9820..10530
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012787.5"
                     /locus_tag="J8C02_RS07715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_07715"
                     /product="TlpA disulfide reductase family protein"
                     /protein_id="WP_211425446.1"
                     /transl_table=11
                     /translation="MKRNRWMHLLCLLALAWFSLADASAMAAPRCTDMNTTEDGHEYAP
                     LQTVKLRYKDWTYPGLDGQPINLRTWMQGKKLVLVVYFAPWCGNWRYEAEVLSRLHAKY
                     QPHGLGIIAVNEYGTTDETRAFFGEAGAPYPVVVESEDRGRIGETSHALYRRMTGDFRT
                     YGSPYNIFLEPAAVIETGEVLVEQITVANGELIEAEAEAFIRKKLGLPAVSAPTAVPPQ
                     PAAPTPQKPSTVND"
ORIGIN
        1 acatgtgatg ggcagccctt cggcccgggc acgccgtacc agttccagcg aaccggccgt
       61 gctcagatgg gcaatgtgaa tgtgcgcccc cgtcaggctg gacaacacga catcccgcgc
      121 cacatccgct tcctcggcgg cgcgggtcat cccccgtacc cccaggcgcg tggagacagc
      181 cccttcgttg atgacgccac cggcggccag gtcacgattt tcacagtgat caatgaccgg
      241 caatccaaag tcgctggcat actccagcgc ccgccgcaag agattggcgt tggcaatccc
      301 atgtccgtca tccgacaggg ccacgactcc ggccgccgcc atcccgccaa tatccgccag
      361 ggcttccccc tgtaaccccc tggtcacagc gccaatggga tagacgcggc acgcggcggc
      421 ttcctgcgcc cggtcgagaa tgtagcgcgt gaccagcggc gagtcgttga ccggcgaggt
      481 gttcgccatg cagcacacgg ccgtgaagcc gccggccacg gccgcgcgcg ttccggtggc
      541 tattgtttcc ttcgccgtaa agcccggctc acgcaggtgc acgtgaacgt ctatgaaccc
      601 cggcgccacg accagcccgg tcgcatccac cagttccgcc tgtgggggga tgtccagatt
      661 cggtcccagc gccgcaatgc ggccttccac caccagaaca tccatgaccg catccaggtt
      721 ttgtgaggga tcgcagacgc ggccgttgcg aatgacgagt gccatgcgct tgcctaaacc
      781 ttggccaggg tcaatccggt ctgatgctga tacttgcccg cgcggtcact gtaggaaacg
      841 gcgcattcct catccgactc gaagaagatg atctgcacga atccttcttc ggcatagagc
      901 cggaccggca ggttggcagc attgtacagc tcgatgacca gccgcccctt ccagtcggct
      961 tcgagcggcg tggtgttctg aatcagcccg caacgcgcat aggtgctttt ccccagggca
     1021 atcgccgtga cgttgcgcgg catctggaac tgctcaatcg tcacccccag cgcataagag
     1081 tggggcggca gcaaccagta gcaactgccg tcagccgcag tccgcagcgg gatgtcgagc
     1141 aggttgtcgg gattgaagtt tttggggtcc acttccgtcc cctgaatcgg agaaaagacc
     1201 ttgaactcat cccgcgccag acgacagtca taaccatagc ttgacagccc acagcttatg
     1261 atgcgccggt cttcgacatg ccggatgagc cgccgctcaa agggcgaaat caggttatac
     1321 tcttcgcaca tgcgaaggat ccacttgtcc gacttaatca cggttggttt ccacagcgtg
     1381 taacagcatg gtgaggtaca aggccggtcg tgaccccgaa acccgatgat atggcagttc
     1441 atcccatccg actcaagctc tttcttgccg tcgccggtct gatgctcctg atgagccacg
     1501 ccctgcgcac cacaagcgtc gccaggacgg gcggggccga acccgccccg cagcgtccgc
     1561 gctcggtgga agcttcggaa aaccagaccg gcccgctgtc ggaagtggcc ttttaccgtc
     1621 tcgtccagcg tgtgcgccag gggcaaatcg ccaccgacgc agccatccgg gagttgcgcc
     1681 aacgcggcat tgcctttgaa gtcacggacg aagttctgga ccgcgcccgc cagcttggcg
     1741 cacccggcgc actcatcacc gccctggtcg aactgacgtt tgaaaccggg ccgccgtcgc
     1801 caacggcgcg tcccaaaccc acccgcacca taccttccgg tcccacccct gccaccccgg
     1861 gcccatcccg cgatcatgaa gacatgtccg gcaacgagcc gccggcatca tccgaagacg
     1921 aaacggcgcg tctcagccaa ctgccactca tcgagcaggc ccggtttcat gccctgcgca
     1981 gcgccgatga cctcccggat ttcatcgtca cccaaactat ccgccgcatg gtgcgggacg
     2041 gccgtggtca atggcaaacg cgcgacaccc tcgaaacgga agtccgggtc gagggcggac
     2101 gcgaacgggt cgaactgctg tccatcaacg gacgcaccac ccaacggcgc tttgaagacg
     2161 ttggcggcgc gacttccgtt ggcgattttt ccggtcagct tgccgcgccg ttcctgccca
     2221 gcaccaacac ccgtttccgc gaagccaaac gggaacgcta ccgtgggcgc gtctgtcgcg
     2281 tgtatgactt cgtcgttccc cgggccaatt ccggctacac cctcaccgta cggctctccg
     2341 acggcacacc gcagcgcatt caggtcggct atcagggcag cctgtgggtt gacgaagaca
     2401 ccaagcgcgt gctgcgtatc gaacacacgg caaccgatat tccgccgggc tttcccatgt
     2461 cacaggtcga atcggccgtg gattacgact gggtcacgat tctcggcaag aactactgga
     2521 tgccgctgac ggccgagacc atccaggtga gcgatgccta tcgccaggcc tttcggaatg
     2581 tcagcgagtt tcggaactac cgaaaattcg aaggcgacat caaaatcatc gagtaaaacc
     2641 caccttgaac cccatgccct tccgacagct cgccttgtgt ttctgtctgc tctggtttct
     2701 gcctggcgca agccccgctc cggcgcagcc cccatcgtct gtgaccgcca tccgtacact
     2761 gctcgacaac caggcagccg cctggaaccg gggcgatctg gaaggtttca tggacggtta
     2821 ctggcgctcg ccggaactga cctttgtttc cggcacgacc gtgaccaagg ggtgggaagc
     2881 gacgctggcg cgctaccggc aacgctacca gtccgaagga cgcgccatgg gaacacttga
     2941 cttccaggac ctcgtcatcg agatggtcgg gccgcgcgca gcactcgtac gcggggcgtg
     3001 gcgggtcgta cttcccgaac aggttgcttc cgggcgcttc accctcctgg tacggcgctt
     3061 ttccagcggc tggcgcatcg tttatgacca cacttcctga cgctcaggcg ccctgccgct
     3121 agccgggcag cgacggcagc cgtcggcttt tgtcactttt gcccacaggc cgggtttgct
     3181 ataacgggcg ggtaaggccc atccggtgtg ccccgcactg gtggcatgtg accctcatga
     3241 accgtaccct gcccgctgac ttttccatct caccgaacgt tcacccgccg gttgtcccca
     3301 cgcagcgggg ggtctggggt tggcttcgcc attggcagcg aacgcttttc atcgtgtggg
     3361 ttctggggcg ctttgcatgg atgctgtacc gcgacctccg tcgcgcccgg gctcattcgg
     3421 acggcaacct ggcggcactt ccaaccgaca gactcgaagc ccaggcggcc cggctgcggg
     3481 aacagctcat ccggctcggc ccgacgttca tcaagatcgg gcaggcattg gcaacccgcg
     3541 ccgacctgct gccggtgccg ttcattcagg aactggccaa gctccagaac cgtgtgccgc
     3601 cgtttccgaa cagtgaagcc ttcgccatca tcgagggcga gctgggcgcg ccgatcagca
     3661 aacttttccg caccgttgac ccggaacccg ttgccgccgc cagcctgggg caggtctatc
     3721 gcggcgtccg gcacgacggg caggaagtgg ccatcaaggt gcaacgcccc aacctcgtgg
     3781 cgcgcatcag cgaggatgtg gacatcctgc gccgtctcgc ccgctggatg gccagctcaa
     3841 agcggctctt caaaggcaac gactgggtcg ggatgattga cgagttcgag cgcacaatct
     3901 atgccgaact cgactaccgc aacgaaggcc gcaatgccga acgcttccgg caaaactttg
     3961 ccgactggcc acgggtccac gtgccgacca tcttctggga acagacgacc tcgcgggtca
     4021 tcaccatgga gtttctgcgc ggcatctgtg tgaccgatct ggaagggctg gccgccgccg
     4081 gcattgacgc cagggaagcc aacgagctga tgtatcgcac gtacttcaag caactgcttg
     4141 aagacggctt ctttcacgcc gacccgcatc cgggcaacat tctcatgctg cacgacggac
     4201 ggctggcctt tttcgacttc ggcatggtcg ggcatatctc cccgaccctg cagagccaga
     4261 tggtcagcgc cttttttcac ctcatcgaac gcgatgcgcc gggcatcgtc cgggatttgg
     4321 tcgggctggg gtttctttcg cccgaagccg acatggaagc gtttgcgcgc gtcgtcgaag
     4381 acctgttccg gcgcaaactc gatgtcaacc tctcggaagt acgcttcaag gacctgactt
     4441 acgacctggg cgacatcatc taccgctacc ccttttcgac gcccgcttcg ttcaccttca
     4501 tcatccgggc gctgatgacc ctcgaaggca tcagcatcac gatgaacccg cgcttcaact
     4561 tccttgaagt cgccatgccc tatgcgcgcg acttcctgtt ccgccgcgaa agcgcgcaac
     4621 tgcgggaaaa ggtctgggcc agcctgcacg atgcccgcaa cgggaagctc aactggacgc
     4681 gcgtgtggaa tctcgcccgg acggcgctgg cgctctactt cgcctgaaag gttgcccgtc
     4741 tgcggtgccg ccactccgcc cagcggtcgc gccaccaccg ccgccaccgg gttcgccagc
     4801 cctgccgacg tttgtactcc gccttgtagt cgagcttttt ggcaaacacc cgtgcggcca
     4861 gttccaggcc cgtcagatca atcgctgcca gcgccgcaca ttcttccggt gacagcccga
     4921 aggcgcaggc tgtgttttcc ggcgcggcca aaaactgctc ccggaaagct tcatcggcat
     4981 agagccgcgc caaaaaggct tcaaagtgtg gcgacgacat cagtgcgtac gttccggttg
     5041 gcgttccggt cggcgcgccc ccgtgccagg gcagcgcgcg cggcatcgag ttcatccaga
     5101 agctcggtaa agggcggata gtcgccatcg cgctccagaa tgacgaccag cggctgtgcc
     5161 gtccgccgcg ccacttccgc cagcaggtca aacactggct ggggcgtcgc atgccggtgg
     5221 tcatcaagca gccgccgccc cggaaagcgc gtcgcatgca cccacttccc gcctgccagg
     5281 tggatgtagc caactcgttc caggggaagc cgggcaatgg cttcacgggg gtcaaaatcg
     5341 aagttgcatg cgttggcgta caggttgtgc agatcgagca gcaaaccgtt ttccgtcgcg
     5401 gccaggatgc cttccagcca gctcacttca tcgagcgcac tgccgggcgg ctcgataatg
     5461 gtggagatgt tctcgaccag tggatcactg ccaaccacgg cgcgtgcggc ggcgagattg
     5521 cgtgccgtgc cctcgatggt ggcggccgtc cgcggcgggg ctgccagatg accgacttca
     5581 acgccgccgc cgcgtacaaa ggcgagatgt tccgaccaca gccacggctc gacctcgccg
     5641 atgaggcgtg ccatgtgatc gagccggacg ggatcaaccg gtgccgtcga ggccaacccc
     5701 agcgagacgc cgtgcagcac aagcggcacc tgccgcccca gccagcgcaa cgcctgtcgc
     5761 tccctgcggg gtgcgtcgaa gtaatcgtcg gcgatgactt ccaccacccc gatccgatcc
     5821 agattggaca ggatgtcggc cgccaggggc gcacgccacc caagaccgac gcgatcaggc
     5881 aggatttcca tcatattcag ccgccaccac cggagattca gccatcacac aaccgggcaa
     5941 atccgggcaa cccgcccaag acctagccac aaccgccaca gccaccgccg caactgctac
     6001 aactgccgcc gtcgctgctg caggaactgc tgcaggaact cccacacgaa gagctatcgg
     6061 ttggggcccg gggaaaagct tcccggactt cagggaaaac atccgccggc agggccacga
     6121 cgccataaac accggccagc agggcaatct gtgccgtcga ggcgttggct ttgagggttg
     6181 cggcctgggc gcgcatcccc tcaaacagcg attccagcga cttgatgaca taatcgccaa
     6241 agcgtgtccg gtagtctccg ctaaaattcc aggcccagat cgccgcgaca atcataatca
     6301 gcacggtaaa gccgatgttg ctgtacccat gccacaacgc gaccgccatc ttggtcaaac
     6361 cgacgaccag gataaaaatc agggcaaaca gcgcccgact ggtccgggcc tgtttctggg
     6421 cttcagaggg caacaggccg gctttctcca gctcttcctt gtaaaggtca tccacctgct
     6481 gcttgagacc accctgcccg aacatttcct ccggcttccg gggggttgtg aaaaagcgga
     6541 gtacagctct ttccagagga agtggcagcg acttcgcatc acagtccggc gcggtcacga
     6601 gctgcttttc ctttttttcc gacgactcat tctgcaaaag catcagatgg cgggcttcga
     6661 tgagtacggc tgtggccacc cgcagggcct cattggcgcc cccgcgcagg tatgccagtc
     6721 ggtagggatc agaagtatcg aacttcgtca gttccctgac cggctcggcc acgattcgcc
     6781 gcacatacag catcgtgatc acgcccgcac aagccagcag gtaagccagc agaaacgcgg
     6841 tcttgggcag gcagatgatg acgacggtga aacacagcag cagggtgaac caggtgatga
     6901 tgaacgaccg gaccacccag gcgtcatcgc ctgcaggaga agttgcctgg tttgtggttg
     6961 gggttacgga tttccacggg tcggaaggtt ttggggtgct gaccgggtag gaactcatag
     7021 gctacctcct ggcatcgagc ctgacgttgt caagaagcac atcggtctga ggggtgatga
     7081 ccaacgaaac atggcgcaga tgaactggct taccgcggct cctctcagct ctgccattta
     7141 caccacggta cgcaggcgat gtgacatcct tgtttaaaat ccaaagacgc cgaagattgc
     7201 ccatggacgg caccagaacc ggacgccctg gagcggcaaa ggcacagccg cagtcagggg
     7261 tgtttcgtct taattttcag accgacaccg ccccacacgc aaccgtctcc cgtccgggac
     7321 ggctttccca tccagcatga aacgcgatac cttacctgct tgtcacgacg gttttgatcg
     7381 aagcaccatg gtatccagaa tcccaagcgc caatgtggcg ttgccgatga cacacgagtt
     7441 atccgatgaa ctcccgttga ccaacgaggg gacaggcgat attcccgaca cactgccgtt
     7501 gttgcctctg cgcgacatcg tcatttttcc atttctcatc gttccccttt ttgtacagcg
     7561 cgagaaatcc caacgcgcca ttgaaaacgc cctccccaac cggcgtctga ttgtgctcgc
     7621 cacccagcgc gatccagagc atgaggaccc gaccggcgat gacctgcacc gggttggcac
     7681 gattgcggcc gtgatgcgcc tgctcaaaac cggcgatggc cgggtgcgga ttctcgttca
     7741 gggattggcg cgggcaacgc ttctgcgtgt gaccgacgaa gccggctaca tgcaggcgca
     7801 ggtgcaagcc attcccgaag cctcggtgga gatgaccctg gaagttgaag ccctggtccg
     7861 cgcggtcaag ggtttgctcg aacggatcgt caccctgggc aagcagattt ccgccgaagt
     7921 gctcgccatt gcggcgtcac tggatgatcc gggccgactg gccgacctct gcgcctccaa
     7981 cctcgacgcc aaaatcagcg atgcccaggc aattctcgaa gaaaccgacc ccattgcccg
     8041 tctgcggcgc gttcatgatc tcatggcccg cgaagtgggc attctcacgg tacagcagga
     8101 aatcagcagt caggccaagg gtgagattga tcgctcccag cgcgagttct acctgcgcca
     8161 gcagctcaag gccattcagc aggagttggg cgaagtgtcc gatgccggcg acgaagtggc
     8221 ggcctaccag gaaaaaatcg cggaagcccg ccttccggag ccggcgcggg aggaagcgac
     8281 gcgccaactc aaacgcctcg aacggctcca cccggatgcc gccgaagccg gcctgctgcg
     8341 gacgtatctg gataccctgc tggcgcttcc atggaacacc ttttcggaag accacattga
     8401 ccttcagcac gtcaaagccg tcctcgatgc cgaccattac ggcctcgaaa aggtcaagga
     8461 gcgcattctc gaagccctgg cggtacggcg gctcaaaccg gataccaaag ggctgctgct
     8521 gtgtctggtc ggcccgcccg gcgtgggcaa gacctctctt ggccggtcgg tggccaaagc
     8581 catcgggcgc aagttcgtcc acatttcact gggcggcgtc cacgacgaag ccgaaatccg
     8641 tgggcaccgc cggacctacg tgggcgcgct gcccggacgc atcatccttg ggcttcagca
     8701 ggccgggacg aaaaacccgc tgatgctcct cgatgaagtg gacaaactgg gcaacgactt
     8761 ccggggcgat ccggcctcgg cgctgctgga agtgctcgac ccggaacaaa accacgcctt
     8821 ccgtgacaac taccttggcg tgccttttga cctctcaaaa gtcatgttcc tgctgacggc
     8881 caacgtcacc gacacgattc aaccggccct gcgcgaccgg ctcgaaatcg tgcgcttgcc
     8941 gggctacacc caggaagaaa aactcgccat cgcccggcgg catctcgtac ccaagcagct
     9001 tgccgaaggc ggcctgaccg gcaagcacct gtccatcacg gaaagcgccc tgcggatgac
     9061 cattgcccgc tacacccgtg aggccggcgt ccgccagctc gaacgtgaaa tcggcaagct
     9121 gtgccgcaag gtggcacggc gcgtcgccga aggcgacagc gggaaagtca ccatcacggc
     9181 cgccaatctg gccgattacc ttggcgtccc gaagttcaaa gccgacgcca ttctgtccca
     9241 ggaccgcatc ggcgtggcgg ccggactggc atggacgagc gtcggcggcg acgtgatgca
     9301 cgtcgaagcc ctcctgctgc gcggcaaggg cgggctgctt ctgacgggca agctgggcga
     9361 agtcatgaag gaatccgccc acgcggcact gtcgtatgcc aagtcccgcg cccgcgaact
     9421 gggcatcgaa cccgatgtct tcacacagca tgaccttcac atccacgtcc cagaaggcgc
     9481 gattccaaag gacgggcctt cggctggcat caccatggcg acggccatgg tttcggcgct
     9541 gtcccgccgt cccgtcaggc gcacggtggc catgacgggc gaaatcaccc tgcgcggcga
     9601 tgtcctgccc gtcggcggta tccgcgaaaa aatcctggca gcgcggcggg ccggcatcaa
     9661 aaccgtcatc cttccggcgc agaaccagcc ggatgtcggt gacatcccgg cggaactcgt
     9721 caaaggtctc aaattcatct atgtgcatga ggtcagcgaa gtgtttgccg cggcgctcgg
     9781 caaggccgca aagactttgc cggccaaggg agtcaacaaa tgaaacgcaa ccgctggatg
     9841 cacctgctct gtctgctggc actggcgtgg ttcagcctgg cggacgcatc cgccatggca
     9901 gccccccggt gcacggacat gaacaccacg gaagacgggc atgagtatgc cccgctgcaa
     9961 accgtcaagc tccgctacaa agactggacc tatcccggac tcgacggcca acccatcaac
    10021 ctgcggacgt ggatgcaggg caaaaaactg gtgctggttg tgtacttcgc gccctggtgt
    10081 ggcaactggc gctatgaggc cgaagttctg tcccgcctgc acgccaaata tcaaccgcat
    10141 gggttgggca ttattgccgt caacgaatac ggcaccaccg atgaaaccag ggcttttttt
    10201 ggtgaagccg gcgcgcctta cccggtcgtg gtcgaatccg aagaccgcgg ccggattggc
    10261 gagacctccc atgcgctgta ccggcggatg acgggcgact tccgcactta cggttccccc
    10321 tacaacatct tccttgaacc ggcagcggtc atcgaaacgg gcgaggtgct ggttgagcag
    10381 atcactgtcg ccaatggtga actcatcgaa gccgaggccg aggcgttcat ccgtaaaaag
    10441 ctgggactgc cggcagtttc agcgccaacg gcagttcctc cccaaccggc cgcgccgaca
    10501 ccacaaaagc catctacagt caatgactga cctgctgccg cgcctgtctg cccgggaact
    10561 caatgacctg ctgcacaacg catttccgct cgtgccgccc gggttgtttt gtgtcgaaac
    10621 cgtagaaccc atgcgggtcc gggtgcggat gcgcaggctg gaagagcata tccgccccgg
    10681 cgggacgctt tccggtccgg cgctgtttac gctggcggat acggcgcttt acatggtcgt
    10741 tctggcaatg tgcgggcccg tgctggaagc cgtcaccagt gagatgacga ttcactacct
    10801 gcggcgtccg gcggcgcgcg acgccatcgg cgaggccacg ctcttacgac tcagccggag
    10861 gtcggccgtc ggcgaggttc tcatccgcgt cgcc
//
