LOCUS       NZ_CP072646            22611 bp    DNA     circular CON 02-DEC-2024
DEFINITION  Chloracidobacterium sp. MS 40/45 chromosome 1, complete sequence.
ACCESSION   NZ_CP072646
VERSION     NZ_CP072646.1
KEYWORDS    RefSeq.
SOURCE      Chloracidobacterium sp. MS 40/45
  ORGANISM  Chloracidobacterium sp. MS 40/45
            Bacteria; Pseudomonadati; Acidobacteriota; Terriglobia;
            Terriglobales; Acidobacteriaceae; Chloracidobacterium;
            Chloracidobacterium aggregatum.
REFERENCE   1  (bases 1 to 2667443)
  AUTHORS   Saini,M.K., Costas,A.M.G., Tank,M. and Bryant,D.A.
  TITLE     Genomic and phenotypic characterization of Chloracidobacterium
            isolates provides evidence for multiple species
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2667443)
  AUTHORS   Saini,M.K., Costas,A.M.G., Tank,M. and Bryant,D.A.
  TITLE     Direct Submission
  JOURNAL   Submitted (29-MAR-2021) Department of Biological Sciences, Tokyo
            Metropolitan University, 1-1, Minami-Osawa, Hachioji, Tokyo 1920397,
            Japan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Canu 1.8 assembler v. 1.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 1x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018304805.1-RS_2024_12_02
            Annotation Date                   :: 12/02/2024 00:41:57
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 3,029
            CDSs (total)                      :: 2,976
            Genes (coding)                    :: 2,951
            CDSs (with protein)               :: 2,951
            Genes (RNA)                       :: 53
            rRNAs                             :: 1, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 1, 1, 1 (5S, 16S, 23S)
            tRNAs                             :: 47
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 25
            CDSs (without protein)            :: 25
            Pseudo Genes (ambiguous residues) :: 0 of 25
            Pseudo Genes (frameshifted)       :: 7 of 25
            Pseudo Genes (incomplete)         :: 18 of 25
            Pseudo Genes (internal stop)      :: 2 of 25
            Pseudo Genes (multiple problems)  :: 2 of 25
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 04:01:44
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1171661
            Orig. end                         :: 1194272
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP072646.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22611
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="3"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22611
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22611
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12611](-)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12611)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    complement(1443..1462)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.39"
                     /tool="antismash"
     gene            1504..2088
                     /locus_tag="J8C02_RS04915"
                     /old_locus_tag="J8C02_04915"
     CDS             1504..2088
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015147.5"
                     /locus_tag="J8C02_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04915"
                     /product="LEA type 2 family protein"
                     /protein_id="WP_211426818.1"
                     /transl_table=11
                     /translation="MDGQGLRRRQFLRYATSGVCGSVCGLLAAGLTDTGLAEAGVLPAA
                     DEGKLPKGFREPTLTLEELEVRQVDYPLADVLAHIAIDNPNQALTLSKLTYRIVLNGVE
                     CGTGEHPEKLTLPKKAALALSLPITADLSSVPHLGINTLLQSRLGEGVFINYVIHVAFE
                     VSVLWLFKRHVKARLTGRLPLREVLGKLSLP"
     gene            2111..2578
                     /gene="dtd"
                     /locus_tag="J8C02_RS04920"
                     /old_locus_tag="J8C02_04920"
     CDS             2111..2578
                     /EC_number="3.1.1.96"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dtd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015922664.1"
                     /locus_tag="J8C02_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04920"
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="WP_211426819.1"
                     /transl_table=11
                     /translation="MRLVIQRVTQASVTVGGKLVGRCDRGLCILVGVTHRDTTADADWL
                     AEKTANLRIFEDEAGKMNRSLLDIGGEALVVSQFTLYGDARKGRRPSFTAAAPPETAEP
                     LVTRYADALRLLGIPVETGVFGAMMQVEIHNDGPVTLILERGGTSVGAEIE"
     gene            complement(2555..3979)
                     /locus_tag="J8C02_RS04925"
                     /old_locus_tag="J8C02_04925"
     CDS             complement(2555..3979)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS04925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_04925"
                     /product="hypothetical protein"
                     /protein_id="WP_211426820.1"
                     /transl_table=11
                     /translation="MGRAAATYRTYLLKSSVLPLALLLFFGGLLTAQADIAVERQVALY
                     PGYTLSSTSSMRTLADVRLLTALPKGDKPIAIDGLPELMRVGDTRTVTFRFAGDGVSAR
                     LAGAVAFESHPVRDAIYHSAGRILADRSRLSAVLDIDVLPSPAPNAVVWRVTARHAGMA
                     GVLAVCASRAPEGEVVSQVAAIRVLDATAAGSLPSSSVKAEPPPAFLPLYVGERMTWSG
                     FAQSLAGRLPVFDFAVLSLDPGCIEGTFSNSTLAVQGNTAGRALLVGVLGDEQAWTPFV
                     TTVEVSARPTATEPRLRGFVNNFVTLKNRRVMVLGDHLERASQVSLLAEDGTFLSLPFR
                     AWSGRLGLFELPPRVGRYTVWLADEQGQQLTDTHTIVCHNIQVTNVARVHLPGRSSIPT
                     VGLFVRGQGLGDTPTLIVNGIETQASVKKSLRGLFNQRVYFRLPAEVLREPYVSVQVMN
                     PDGYVSDTYLLDLRAN"
     misc_feature    complement(4060..4071)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 16.49"
                     /tool="antismash"
     gene            4118..4960
                     /gene="cpdA"
                     /locus_tag="J8C02_RS04930"
                     /old_locus_tag="J8C02_04930"
     CDS             4118..4960
                     /EC_number="3.1.4.53"
                     /GO_function="GO:0004115 - 3',5'-cyclic-AMP
                     phosphodiesterase activity [Evidence IEA]"
                     /codon_start=1
                     /gene="cpdA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012702838.1"
                     /locus_tag="J8C02_RS04930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04930"
                     /product="3',5'-cyclic-AMP phosphodiesterase"
                     /protein_id="WP_211426821.1"
                     /transl_table=11
                     /translation="MAEPSQNDNSRGSNGPVHVLHVTDSHLFAQRTGRLLGLVTYDSLT
                     AVLTAAAAEPPDMVLATGDLAQDGTAQAYAHLTEAFSSFAAACPLPPPVYWLPGNHDEP
                     AVMRATLTRAPLRPETEVVVGGWYVILLDSTVSGEVGGVLSEGELARLDAGLRAHADRP
                     ALVCLHHNPVATRARWMDDIGLANAAAFFAVLDRHPQVRGVLWGHVHQAMDVERHGVRL
                     MASPSTCIQFKPETVEFGLDPSAPGYRRLWLHPDGRLETRVFRVNNFAGCADPDATGY"
     misc_feature    complement(4129..4143)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.47"
                     /tool="antismash"
     gene            complement(4983..5318)
                     /locus_tag="J8C02_RS15100"
     CDS             complement(4983..5318)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003019039.1"
                     /locus_tag="J8C02_RS15100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_246604660.1"
                     /transl_table=11
                     /translation="MTNCTTHPDHAHTHDAACGHTRIQHDDHVDYLHDGHLHFQHGDHY
                     DEHRIPVSRTNPDGCAPYPTACAHVHGPDCGHEAVPHGDHVDYLVDGRLHHVHDGHCDD
                     HGPVTVL"
     misc_feature    5365..5377
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.32"
                     /tool="antismash"
     gene            complement(5377..5727)
                     /locus_tag="J8C02_RS15105"
     CDS             complement(5377..5727)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1058: ArsR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014099511.1"
                     /locus_tag="J8C02_RS15105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_246604661.1"
                     /transl_table=11
                     /translation="MASPCSNQHQPAEREVLTAPLAWRIADMFKALGDPTRVKIIALLD
                     AGELCVGEICLTLGMSQPAISSQLRLLRTLGIVSVRREGKHAYYRLADEHVRHLFHQGL
                     AHARHDIIHDDE"
     misc_feature    complement(5763..5776)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.8"
                     /tool="antismash"
     gene            complement(5829..7316)
                     /locus_tag="J8C02_RS04940"
                     /old_locus_tag="J8C02_04940"
     CDS             complement(5829..7316)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012640.5"
                     /locus_tag="J8C02_RS04940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04940"
                     /product="chorismate-binding protein"
                     /protein_id="WP_211426822.1"
                     /transl_table=11
                     /translation="MSTLQFQPATYDAFLALAQEATVVPVAVTLPADVHTPVGVFLKVA
                     GQSGDVGLFENQRLERHLPPYTLIGLDPRWIITGRDGKVELRTPHATLERTETLLQAVR
                     RRLRADILAPVADIPALASAAFGYLAHEASHQLHGVPPRVPPTVEGVLAAFGTVIVFDH
                     AHQRLHIVVNVPTDGRTERLEADYAAAQQRLQSVAQQLDGPFPALPALPRPTSRSIVTP
                     MTPEQFRQAVEHTEQCIAAGELHVATLAQRLERPTAAHPFSIYRLLRATPSLLGTFFFS
                     AGGTAVLGGIAHNVVQGRGESLRAYLATHERPAGSTEAELSLALAELASDESATGQHIG
                     FVDALRNDLGQIAGYGSLELEILAQAEAASQQVRLISTLQSQLASGRDYLDVLAARLPS
                     AQWTGLPKRPALRLTTALEPVRRHHFGSQFCLLVPQVESLACETCHVLEVTNQVARFYA
                     FAALTGDTNLSEALVKGAKTAQHIAALMEQAEAQAAH"
     gene            complement(7336..8067)
                     /gene="hisIE"
                     /locus_tag="J8C02_RS04945"
                     /old_locus_tag="J8C02_04945"
     CDS             complement(7336..8067)
                     /EC_number="3.5.4.19"
                     /EC_number="3.6.1.31"
                     /GO_function="GO:0004635 - phosphoribosyl-AMP
                     cyclohydrolase activity [Evidence IEA]"
                     /GO_function="GO:0004636 - phosphoribosyl-ATP diphosphatase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000105 - L-histidine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hisIE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014099513.1"
                     /locus_tag="J8C02_RS04945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04945"
                     /product="bifunctional phosphoribosyl-AMP
                     cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE"
                     /protein_id="WP_211426823.1"
                     /transl_table=11
                     /translation="MTEAIRFDANGLVPVVIQDATTNEVLTLAYMNATSYQLTCETGEV
                     WLWSRSRQSLWHKGATSGHTQRVVDIRLDCDGDALVVRVEPRGPACHTGATSCFFQSLL
                     PSGTTAKTDEGPPAAQAPDGTTAIAPPEVRLVPHSALELGILLDELYALIRERQAKRPE
                     GAYTTYLFTAGLDKILKKVGEEAAETIIAAKNEPRMELAAEMADLLYHLLVLMVARDVT
                     PHDVAEILRSRAGKRRPLPTE"
     gene            complement(8167..9117)
                     /locus_tag="J8C02_RS04950"
                     /old_locus_tag="J8C02_04950"
     CDS             complement(8167..9117)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J8C02_RS04950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J8C02_04950"
                     /product="hypothetical protein"
                     /protein_id="WP_211426824.1"
                     /transl_table=11
                     /translation="MALAQVVYGRRLATTRPVPFLQPVHLGEDPADGFLAFEERPTTPR
                     PPACAPWYQGQIVDARQGPELIGYHEPERGLFHFCYNVGTAFTYDHPQRRITALWSPPQ
                     TFEDTCTYLTGPILGFVLQIQQRVCLHASTVVMGTSAVAFVGPNGAGKSTLAAALLRRG
                     AEVIAEDVAAIERQAEGFVVHPGPRAIRLWDPSVTALYGRPDALPCISKHWEKRYLPLD
                     TPEQPRPARLTAVYLLEVVPAEAPVSSTQLSPMQAVTKLLPNIYPDWLPLPEARVAILD
                     TLTQLATVVPIRRLSLPNSFCRLDEVCDYVLARHG"
     misc_feature    9350..9366
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 19.18"
                     /tool="antismash"
     misc_feature    complement(9351..9369)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 21.0"
                     /tool="antismash"
     misc_feature    complement(9771..9785)
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 19.74"
                     /tool="antismash"
     gene            complement(10001..11830)
                     /locus_tag="J8C02_RS04955"
                     /old_locus_tag="J8C02_04955"
     CDS             complement(10001..11830)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.5"
                     /locus_tag="J8C02_RS04955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04955"
                     /product="asparagine synthetase B"
                     /protein_id="WP_211426825.1"
                     /sec_met_domain="GATase_7 (E-value: 4.2e-20, bitscore:
                     68.9, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 7.6e-26, bitscore:
                     88.6, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSFFVIFHPDGRPVEPPLAARLLQRLAWRGPDGQSHWTDAHVAL
                     GYAHLRVDDLTRVPPPLTFDGQVWLAADIRLDAREELCRAIQAAGGEADQDMPDARLLW
                     QAYRLWELDCLRHLQGDFAFALWDAHRRRLFCARDPFAVKPLYYSYQPGLFVASSDLET
                     ICAHPEIPASLPADLDDFAIADFLIEGMKLDEDGTFYRAIRRLPRATALCLEGGARRQW
                     RYWDWPTDGYLRYARTSDYIEHFQALLEQAVADRLRAPRASVFLSGGLDSNVVTAAARR
                     ACPTTDLRAFTNVFNILIPDRERHFAGLAARGHGIPITFVEHDDWQPYAPHPAGVLLPP
                     EPVHEPFWNGITESYRQAGSHARLILTGQWGDEVMLQETAPCLRDLVARRQFIRLGKAL
                     VAYLVADVRNSFFSLRRQFRRRFGRKHPTQSEIPRWLATDFVTRLCRAGYFERPQPSPP
                     PHPYRRLVPQMLSRVHIANDHEYSDMAFTGAVVEMRYPLLDQRLIGFLLAAPTVPLCLD
                     KWLFRELLRDRLPRAVVRRAKAPLPQFPVTGYIRRHGTGWAQLPPEARHHLACFVNIEA
                     LAVPLVWDARHEAKSFVDLSPLSLYNWLRSKVL"
     gene            complement(11827..12288)
                     /locus_tag="J8C02_RS04960"
                     /old_locus_tag="J8C02_04960"
     CDS             complement(11827..12288)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF033537.1"
                     /locus_tag="J8C02_RS04960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04960"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_211426826.1"
                     /sec_met_domain="PF13471 (E-value: 7.4e-24, bitscore: 81.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKRWLYRLHIFCRLPSEDRASLVTAWLLLLGLPGLCRLVGVRACL
                     RWMQWMVGRQPPPASSATCLAEWVDHQGVLVAWAVRYCPRSPTCLIRAVVLWFLLARRG
                     IVCDLRLGVEKDAQTFEAHAWVEWRGQPVMESPDVRQRYAVFDTPLNAS"
     gene            complement(12285..12611)
                     /locus_tag="J8C02_RS04965"
                     /old_locus_tag="J8C02_04965"
     CDS             complement(12285..12611)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="J8C02_RS04965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04965"
                     /product="PqqD family protein"
                     /protein_id="WP_211426827.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 4.4e-16,
                     bitscore: 55.7, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.2e-13, bitscore: 46.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSLMNRALIPKHVIVRSVADEAILLNLVTEHYYGLDSVAYSMLR
                     QATSCPTLQDALAALLDEYEVEPERLQQDFNTLLEQLRQADLIEIVPPDPVSSDSPPEA
                     APIS"
     aSDomain        complement(12342..12578)
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_J8C02_RS04965_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="5.60E-18"
                     /identifier="RREFam002.1"
                     /label="J8C02_RS04965"
                     /locus_tag="J8C02_RS04965"
                     /protein_end="90"
                     /protein_start="11"
                     /score="55.7"
                     /tool="antismash"
                     /translation="KHVIVRSVADEAILLNLVTEHYYGLDSVAYSMLRQATSCPTLQDA
                     LAALLDEYEVEPERLQQDFNTLLEQLRQADLIEI"
     gene            12773..13930
                     /locus_tag="J8C02_RS04970"
                     /old_locus_tag="J8C02_04970"
     CDS             12773..13930
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF046309.1"
                     /locus_tag="J8C02_RS04970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04970"
                     /product="50S ribosomal protein L11 methyltransferase"
                     /protein_id="WP_211426828.1"
                     /transl_table=11
                     /translation="MYSDYVTLTYHASLIADERRVQPFQSAIESVVRPGDVVADIGCGT
                     GILTLLACRAGARRVYAIDEGPIIELARLIIEQNGYADRVTFINHLSTRARLPEPVDVI
                     ISETIGNYGAEERILPTLRDACRRWLKPGGKLIPQAIELYCAPITWPEAEPALSVWRQP
                     VCGFDFSSALSFAVNQQYSHRLGSQHVLAEGRCYCRVDLTPAVLRGDALPKVAGTVSFR
                     VAQPGVMHGIGGWFKAWLAEDITLTNSPYEPPTSWGHLCLPIAEPLPVAVGDEVEVTLR
                     AVGGGSVLCWDVTWRGVGGASKTFRHSDFEGWLATPERLRPLSPTAAPGLGVEGKMQLF
                     LLTKLDAGWTVEQVARGLRESFSSEFPTDEDALVYVKRQALKFAR"
     gene            complement(13872..15119)
                     /locus_tag="J8C02_RS04975"
                     /old_locus_tag="J8C02_04975"
     CDS             complement(13872..15119)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1226: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF015722.5"
                     /locus_tag="J8C02_RS04975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04975"
                     /product="formylglycine-generating enzyme family protein"
                     /protein_id="WP_211426829.1"
                     /transl_table=11
                     /translation="MAQRKTGWRIWPAGLALGFLWAMTTPTPLVTQVAAQERSTSVGGG
                     KVGGGEATSPPAGGRGRSGGKGTGARPPAVPCPSGPLAPTVALPAEQLSTVTFESPRLD
                     DKGNVVETVKGETQRFVENLGNQVTLELVAVPGGCFTLGNTVSDESESYDNERPPMRAR
                     VLGFYMGRTEVTQAQWREVASWPKVERDLPPSPSKYTGDDLPVDSITWDEAVEFCRRLT
                     RRTGRPYRLPTEAEWEYACRAGATGLFAYGAVLLPTLENYDGSLPYRDEPASQPRKKPT
                     PAGSLGVNAFGLADMHGNVREWCLDTYTSRLTGIHAQGAPVRNIRQEEWAQHRTIRGGS
                     WASLPDGCRCSIREGLHREELLTTLGFRVVLSDRYGEGQPIELDNGESGRTSGFLRLNE
                     RTSAPAFSHRPEHPHL"
     gene            complement(15256..15801)
                     /gene="cobU"
                     /locus_tag="J8C02_RS04980"
                     /old_locus_tag="J8C02_04980"
     CDS             complement(15256..15801)
                     /EC_number="2.7.1.156"
                     /EC_number="2.7.7.62"
                     /GO_function="GO:0000166 - nucleotide binding [Evidence
                     IEA]"
                     /GO_function="GO:0043752 - adenosylcobinamide kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013012533.1"
                     /locus_tag="J8C02_RS04980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04980"
                     /product="bifunctional adenosylcobinamide
                     kinase/adenosylcobinamide-phosphate guanylyltransferase"
                     /protein_id="WP_211426830.1"
                     /transl_table=11
                     /translation="MTRELILVLGGARAGKSRFAQQLAQTKADATGAAVCFIATAEALD
                     EDMQGRILRHRAERPAEWRTIEEPRALAAAYAQAAEAGVVVVDCLTLLVSNWLLAMPHD
                     EAQCLNALETTLAAFLQTFSRREQTVIVVSNEVGLGIVPDNALARRYRDLLGNVNQSVA
                     AAATEVYFVVAGLPWRIK"
     gene            complement(15801..17477)
                     /gene="hutU"
                     /locus_tag="J8C02_RS04985"
                     /old_locus_tag="J8C02_04985"
     CDS             complement(15801..17477)
                     /EC_number="4.2.1.49"
                     /GO_function="GO:0016153 - urocanate hydratase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006548 - L-histidine catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hutU"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014099521.1"
                     /locus_tag="J8C02_RS04985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04985"
                     /product="urocanate hydratase"
                     /protein_id="WP_211426831.1"
                     /transl_table=11
                     /translation="MTRILRAPRGAELSCRNWQIEAAYRMLHNNLDPEVAERPEDLVVY
                     GGAGKAARNWACFEAIGDTLRRLGEDETLLIQSGKPVGVFRTHPDAPRVLLANSNLVPR
                     WATWEHFDELDRRGLMMYGQMTAGSWIYIGTQGIVQGTYETFAEMGRQHYGGDLRGRWV
                     LTAGLGGMGGAQPLAAVFAGAAALVIECQVSRMEARCRTRYLDEWTDNLDDALRRIERY
                     TAENKAVSVGLLGNAAEILPALVERARQGGPRPDIVTDQTAAHDLIHGYLPAGWTVEQW
                     QAAQRDPAQHGTLRQAAAESCARHVRAMLDFQALGARVVDYGNNLRQVAFDEGVTDAFT
                     IPGFVPAYIRPLFCRGKGPFRWVALSGDPEDIHRTDRRLMELFPDNDHLHRWLTMAEQR
                     IAFQGLPARICWLGLGERHRAGLAFNEMVRKGELKAPVVIGRDHLDAGSVASPNRETEQ
                     MRDGSDAVSDWPLLNALLNTASGATWVSLHHGGGVGMGYSQHAGMVIVCDGTEAADRRL
                     ERVLWNDPATGVMRHADAGYADAVECARAQGLWLPMLDTDA"
     misc_feature    complement(17490..17499)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 15.27"
                     /tool="antismash"
     gene            17644..18867
                     /gene="hutI"
                     /locus_tag="J8C02_RS04990"
                     /old_locus_tag="J8C02_04990"
     CDS             17644..18867
                     /EC_number="3.5.2.7"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0016812 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds, in cyclic amides
                     [Evidence IEA]"
                     /GO_function="GO:0050480 - imidazolonepropionase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019556 - L-histidine catabolic process to
                     glutamate and formamide [Evidence IEA]"
                     /codon_start=1
                     /gene="hutI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014099522.1"
                     /locus_tag="J8C02_RS04990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04990"
                     /product="imidazolonepropionase"
                     /protein_id="WP_211426832.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 5e-21, bitscore:
                     72.3, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLALWRNARLATLANPDAWGWIEDGAMVVAGEYLHWVGETRHLPR
                     SLPIAEEHDLGGALVTPGLVDCHTHLVYGGTRADEFEARLHGATYADIARQGGGILSTV
                     RATRAASDDELLAAAIRRARALLAEGVTTVEIKSGYGLTCADEARCLRIARQLAQRLPL
                     TVCTTYLAAHALPPEFAGRPDDYIAEVCAWLPEVHAAGLVDAVDAFCENIGFSVEQTRR
                     IFETAWQLGLPVKLHAEQLSDQGGALLAAEFGALSCDHLEYVSPAGIRAMAQSGTVAVL
                     LPGAFYFLRETQRPPVAVLRAAGVPMAVATDHNPGSSPTLSLLLMLNLACTLFQLTPEE
                     ALRGVTVHAARALGLADRGILAAGRRADFVVWPLAHPRELAYWFGGCHPQQVILGGKEV
                     VRHGVIVG"
     gene            18848..19660
                     /gene="hutG"
                     /locus_tag="J8C02_RS04995"
                     /old_locus_tag="J8C02_04995"
     CDS             18848..19660
                     /EC_number="3.5.1.68"
                     /GO_function="GO:0050129 - N-formylglutamate deformylase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019557 - L-histidine catabolic process to
                     glutamate and formate [Evidence IEA]"
                     /codon_start=1
                     /gene="hutG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014099523.1"
                     /locus_tag="J8C02_RS04995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_04995"
                     /product="N-formylglutamate deformylase"
                     /protein_id="WP_211423063.1"
                     /transl_table=11
                     /translation="MASSSVEPVFELHPGDVPVLISLPHVGTVVPPEIAADWTDEARTL
                     PDTDWHLGELYAFARQLDVGILQARLSRYVVDVNRPPDDLPLYHGKHYTELCPTRMFTG
                     EPIYCEGKTPDAMEIARRRAHYWQPYHDALEQELTRLQARHGYVILWEGHSIKSRLPWL
                     FEGTLPDFNLGTASGASCAPELRQALCAALAAQKELTYVADDRFKGGYITRHYGRPEQG
                     RHAVQLEMAWSCYMRDEAPPYRIDPERAGRLLPILEKLIITALAWSPS"
     gene            19657..21087
                     /gene="hutF"
                     /locus_tag="J8C02_RS05000"
                     /old_locus_tag="J8C02_05000"
     CDS             19657..21087
                     /EC_number="3.5.3.13"
                     /GO_function="GO:0050416 - formimidoylglutamate deiminase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019557 - L-histidine catabolic process to
                     glutamate and formate [Evidence IEA]"
                     /codon_start=1
                     /gene="hutF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014099524.1"
                     /locus_tag="J8C02_RS05000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J8C02_05000"
                     /product="formimidoylglutamate deiminase"
                     /protein_id="WP_211426833.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 3e-33, bitscore:
                     112.5, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLEPVPPKALWTPLAWLPHGWQRHVLLTIGQDGCWADVETNVLT
                     PPPEAVPLAGALLPGLVNAHSHAFQRAFAGLAETTTGEQDDFWSWRSRMYHLAARITPE
                     LLRAIAAQLYLELLRGGYTQVCEFHYLHRDVSSEPYPEPLTMLEALIHAAEDVGIGLTL
                     LPTVYERAGFGQPDLLPEQRRFFATPDFVWEVVKAVEAGNRPGIHVGLALHSVRAVRPE
                     SFDHLRRLAEDFTGPIHIHVAEQVAEVEACLRATGARPVAWLAREGYLDPRWQLVHATH
                     TDAAEREAIARSGAGVVVCPTTEANLGDGFVDLPAWAELGVPLAIGSDSHVNRDWREEL
                     RWLVYSTRLLTQRRGIAGLPSPAASLFAGAQLAGGDAAGLPNWGLTPGARADALVLATG
                     AASLIGATPEHLLEAVVFSSPGPAWSDVFVAGRWWLQRGRHPRQGRIQARFRAAMETLW
                     ASARPCSRNTEPDHPPQP"
     misc_feature    complement(21461..21479)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.49"
                     /tool="antismash"
     misc_feature    complement(21944..21959)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.35"
                     /tool="antismash"
     misc_feature    22378..22391
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.82"
                     /tool="antismash"
ORIGIN
        1 cattcgtccg acatcggtct ggcgcacgcc ggaaaaggtc gccccttacc tcgaagccga
       61 tgagctggcc ctgtaccggc tgatctggca gcgctttgtg gcctcccaga tgacaccagc
      121 cctctttgac gccacaacga ttgacatcga aggtggcccg ggctttgtct tccgggcaac
      181 cggggcggtg ctccgtttcg atggttttct agcggtctat gaggaaggaa aggacgaacg
      241 cgataccgac gacgaggcct tggcgctcaa actgccgcgc gtcacggaag gggagcgcgt
      301 cgaatgccgt gaactccagg tcaaccagag ttttacccgt ccaccggccc gctacacgga
      361 agccactctg gtcaaaaccc ttgaggagca gggtatcggg cgcccttcga cctatgccca
      421 gacgctgtcg gtcattcagt cccgcaacta tgtcgagaaa cgtgacggac ggtttcatcc
      481 cacgcccctt gggatggtga ttgccgatgt cctcacggaa aatttcgccg atctttttga
      541 tccgggctac acggcggtgc tggagacaca gctcgacgaa atcgaggaag gcaaactcaa
      601 ctggagggaa gcactcgaag agttttaccg gaagtttcgc gctgacctgg aagccgccaa
      661 agtcaacctc aaaaaggcca aggatggcgt ggctacggat gaacgctgcc acaagtgtgg
      721 ggcggccatg gtgctcaggc tggggcgctt tggaaagtac ctgtcatgca ccaacccgga
      781 gtgcaaggcc acccgggatt atggcacgcc accggcggcg accgctgagc atggcacgtc
      841 tgccgaggtg gccggggaaa ttgcctgtga cgcctgcggg cgtccgatgg tgcgcaaacg
      901 gggacgctgg ggtgagtttc tcgcctgcac gggctacccg gagtgcaaaa cgacccgcaa
      961 tctgacccgg accggcgcgc ccaagcccgc ccccatccag ctcgatgaaa cctgtccgac
     1021 ctgcggccag ccactggccg tccggcaggg acgctatggc gagttcatcg gctgctcaaa
     1081 ctatccgaaa tgcacgtata tcaagcgcga agccattctg ccttgcccgc agccgggctg
     1141 cggcggcgac atcaccgaac gccggtcagg acgtgggcgg gtgttctaca agtgcaccaa
     1201 tacggactgt gaggccatct attgggacag gccggtaagc catccatgcc caagctgtgg
     1261 gtctcccttt acgctccaga agacgaatgc ccagggggag gcgtaccatt actgcgccga
     1321 caaggaaaat tgcggctgga cggaactccc cgctgagaag cgaaagaaaa aagacacacc
     1381 gccgtcatcc aaaaagcggt ctgcctctga ggcagcgtga tcagctcccg ccgggtgctg
     1441 acccagggtg ggtaggcccg gcgcattgcc ttggcttcgg gagctgtcct acaacatgtt
     1501 gccatggacg gtcaggggct gcggcggcga caatttcttc ggtatgccac atccggtgtc
     1561 tgtggcagtg tctgtgggct gctggccgcc ggtctgaccg acaccggtct ggcggaagcc
     1621 ggcgtccttc ccgcagccga tgaagggaag ctgcccaagg gctttcgcga gccaaccctg
     1681 acgctcgaag aactcgaagt ccggcaggtg gattacccgc ttgccgatgt gctggcccac
     1741 atcgcgattg acaatcccaa ccaggcgctc accctgagca aactgaccta tcgcattgtg
     1801 ctcaatggcg tcgagtgtgg gacaggagag catcccgaaa agctgacgct acccaaaaag
     1861 gctgccctgg ccctgtcatt gccgataacc gccgatcttt cctcggtgcc gcaccttggg
     1921 atcaacaccc tgttgcagtc ccgcctgggc gaaggggtct tcatcaacta tgtcatccat
     1981 gttgcctttg aggtgagcgt gctctggctt ttcaaacgcc acgtcaaggc caggctcacc
     2041 gggcggctgc ccctgcgcga ggttctgggc aagctgtccc tgccgtaggc gcacttcaac
     2101 cacagattcc atgcggcttg tcatccagcg tgtaacccag gcttccgtga ccgtcggggg
     2161 aaagctcgtc gggcgctgcg accgtggtct gtgcattctt gtcggcgtca cgcaccggga
     2221 taccactgcc gatgccgact ggctggccga aaaaacggcc aacctgcgca tcttcgagga
     2281 tgaagccggg aagatgaacc gctccctgct cgacatcggt ggcgaggcgc tggtggtttc
     2341 ccagttcacc ctctacggcg atgcgcgcaa aggacgccgc ccttcattta ccgccgcggc
     2401 tcccccggag accgccgaac cacttgtgac gcgctacgct gacgccctcc ggctgctggg
     2461 cattccggtc gagaccggtg tctttggcgc catgatgcag gtcgaaatcc acaacgacgg
     2521 cccggtgacg ctcattctgg agcggggtgg aacatcagtt ggcgcggaga tcgagtaagt
     2581 acgtgtccga aacatacccg tccgggttca tcacctggac actgacgtaa ggctcacgca
     2641 ggacttccgc cggaagccgg aaatacaccc gctggttgaa cagcccacgg agagactttt
     2701 tgacactggc ctgtgtctcg atgccgttga cgatgagcgt cggggtatca cccaacccct
     2761 ggccacgtac aaacagccca acggttggta tggatgaccg accgggcagg tgaacccgcg
     2821 ccacgttggt gacttgaatg ttgtggcaaa caatggtgtg cgtatcggta agctgctgcc
     2881 cctgctcatc ggccagccag acggtgtagc gtcccacgcg cggcggtaac tcaaacagcc
     2941 ccagccgccc cgaccaggca cggaagggaa ggctcagaaa agttccgtct tcggcgagca
     3001 gcgaaacctg tgaggcccgt tccagatggt cgcccagcac catgacgcgc cggttcttga
     3061 gcgtgacgaa gttgttgaca aagccgcgca gacgcggctc ggtggctgtc ggacgcgctg
     3121 aaacctcgac ggtggtcaca aagggcgtcc aggcctgttc gtcgccaagc acaccgacca
     3181 gcaatgcacg cccggcggtg ttgccctgta ctgccagcgt actgttggag aaggtgccct
     3241 cgatgcagcc cggatcgagg ctcaggacgg caaaatcaaa gaccggcagc cgtcccgcga
     3301 gtgactgggc aaaaccactc caggtcatcc gttcgccaac gtacaggggc aaaaacgccg
     3361 gcggcggctc ggctttgacg ctggatgacg gcaggctgcc ggcggcggtg gcgtccagga
     3421 cgcggatggc agcaacctga gaaacaacct cgccttccgg tgcccggctg gcgcagaccg
     3481 ccagaacccc ggccatcccg gcgtggcgcg ctgtcacccg ccagacgact gcattcgggg
     3541 ccggactcgg aagcacatcg atgtcaagga cggccgaaag gcggctgcgg tcggccagga
     3601 tgcgcccggc cgagtggtag atggcatccc gtaccggatg cgattcaaag gccaccgcgc
     3661 cggccaatcg cgccgagacg ccatcgccgg caaaacgaaa cgtcaccgtc cgtgtatcgc
     3721 cgacgcgcat caactccggc agcccgtcaa tcgcaattgg cttatcacct ttcggcaggg
     3781 ccgtcaggag gcggacatcg gccagcgtgc gcatcgaact cgtgctggac agggtgtagc
     3841 caggatacag cgccacctgc cgttcgacgg caatatcagc ctgggccgtc aaaaggccac
     3901 caaagaagag aagcagtgcc agtggaagta ccgatgactt caaaaggtat gtccggtagg
     3961 ttgcggcggc cctgcccatg gcaaattacc tcggcatcaa ggagagtttg tggacatccg
     4021 gtggtacccg gttatgtaac acagtgcctg ccaacaacgg aaaagctttt catggcaaca
     4081 gaaagcggcc tacagtgccg tatcacacgc agaagccatg gctgaaccat ctcaaaacga
     4141 caattccaga ggttccaacg gcccggtgca tgtcctccac gtcacggaca gccatctgtt
     4201 tgcccagcgc accggtcgcc tgctcggcct ggtgacatac gattccctga cggccgttct
     4261 caccgctgcg gctgccgaac cacccgatat ggtgctggct acgggtgatc tggcgcagga
     4321 cggcaccgcg caggcctacg cgcacctgac cgaagccttc tccagctttg ccgccgcctg
     4381 tccgctcccg ccgccggtct attggttgcc cggcaaccac gacgaaccgg cggtgatgcg
     4441 cgcaacgctg acccgtgcgc cactacgccc ggagaccgaa gtcgtcgtgg gcgggtggta
     4501 cgtcattctg ctggactcga cggtttccgg ggaggttggc ggcgtcctgt ccgaaggcga
     4561 gttggcacgt ctcgatgccg gactccgcgc ccacgctgat cgtccggcgc tggtctgcct
     4621 gcatcacaac cccgtggcga cacgcgcccg gtggatggat gacatcgggc tggccaatgc
     4681 cgccgccttt ttcgccgttc tcgatcgcca tccccaggtg cgtggcgtgt tgtgggggca
     4741 tgttcaccag gcaatggatg tcgaacgcca cggcgtacgg ctgatggcgt cgccctcgac
     4801 atgcattcag ttcaaaccgg aaacggttga attcgggctt gacccctcgg cgccaggcta
     4861 ccggcggctg tggctccatc ccgacggccg gttggaaacc agggtgttcc gggtcaacaa
     4921 ttttgccggt tgcgccgatc ctgacgcaac cggctactag atgctccagg tgagtccggt
     4981 cgttacagca cggtgacggg gccgtgatcg tcacagtgcc catcgtgcac gtgatgcagc
     5041 cgcccgtcca cgaggtaatc cacatggtcg ccgtgcggaa cggcctcatg tccgcagtcc
     5101 gggccatgga catgcgcgca tgctgtgggg tatggcgcgc atccatcggg gttcgtgcgg
     5161 ctgacaggaa tacggtgttc gtcgtagtgg tcgccgtgct ggaaatgcag gtggccgtcg
     5221 tggagatagt ccacgtgatc atcgtgctga atgcgcgtat gcccgcaggc ggcgtcatgg
     5281 gtgtgggcgt ggtcggggtg ggttgtacag ttcgtcatcg gatgactcct ttcaggtaga
     5341 tgaggggtaa ggccattccg ccagatgcct tttgcattac tcgtcatcgt gaatgatgtc
     5401 gtgacgcgca tgggccagcc cctggtggaa cagatgccgg acgtgttcat ccgccaggcg
     5461 gtagtaggcg tgcttgcctt cgcggcgcac ggagacaatc cccagcgtac gcaacaaacg
     5521 gagctggctg gaaatcgccg gctgcgacat cccaagcgtc aggcatatct cgccgacaca
     5581 cagttcgccg gcatcgagca gggcgatgat tttcacccgg gtcggatcgc cgagcgcctt
     5641 gaacatatcg gcgatgcgcc aggccagcgg ggccgtgagc acttcccgtt cggctggttg
     5701 gtgttgattg ctacatgggg aggccataca ttaccactaa cggataagca tttgattatg
     5761 tgttttatct gaaagtcccc ctggcgtcaa gcggggaagc tggtgctgcc ggttgggaag
     5821 tgccggattc agtgtgcggc ctgggcttcg gcttgttcca tcagggccgc aatatgctgg
     5881 gctgttttgg cccctttgac caaggcttcg ctgaggttgg tatcgccggt cagggcggca
     5941 aaggcataga accgcgcaac ctggttggtc acttcgagga cgtgacaggt ttcgcaggcc
     6001 agcgattcca cctgtgggac aagcaggcag aactggcttc cgaagtggtg tcggcggaca
     6061 ggttcaagcg cggtcgtcag gcgcagggca gggcgtttgg ggagtccggt ccactgggcg
     6121 ctgggcaggc gcgcggcgag aacatccaga taatcacgcc ccgacgcgag ttgggactgg
     6181 agtgtcgaaa tgagccgcac ctgttgcgag gcggcttccg cctgggcaag aatttccagt
     6241 tccagcgagc cgtagccggc aatctgtccg aggtcgttgc gaagcgcatc cacaaaaccg
     6301 atgtgctgac ccgttgccga ctcgtcgctg gccagctcag ccagcgccag ggagagttcg
     6361 gcctcagtac ttccggccgg gcgctcatga gtcgccagat aggcacggag gctttctcca
     6421 cgtccctgaa caacattgtg ggcaatgccg ccaagaaccg ccgtgccacc ggcagagaag
     6481 aagaacgtgc ccaacaggga gggggtcgcc cgcagcagcc ggtagatcga aaagggatgg
     6541 gcggccgtcg gacgttccag gcgctgcgcc agcgtggcca cgtgaagctc accggcggca
     6601 atgcactgtt ccgtgtgttc aacggcctgc cggaactgct ccggtgtcat gggggtgacg
     6661 atggaacgcg acgttgggcg tggcagcgcc ggtaacgccg ggaatgggcc gtcgagttgt
     6721 tgcgccacgg actggaggcg ctgttgcgcg gcggcgtagt cggcttcgag ccgttcagtc
     6781 cgtccgtcgg tcgggacatt gacaacgata tgcaggcgct ggtgggcatg gtcaaacacg
     6841 atgaccgtgc caaaagcggc gaggacgcct tccacggtcg gcggtacgcg gggcggtacg
     6901 ccgtgaagct ggtgggacgc ttcgtgcgcc agatagccaa aggcggcact ggccagcgcc
     6961 ggtatatccg ctacgggcgc gaggatgtcg gcccgaagcc gccgccggac ggcttgcagc
     7021 agcgtttccg tgcgttcgag cgtggcgtgc ggggtgcgta gctcaacctt cccatcccgg
     7081 ccggtgatga tccagcgtgg gtcgagaccg atgagggtat agggggggag atggcgttcg
     7141 aggcgttgat tctcgaacag gccgacatcg ccggattgac cggccacttt cagaaagacc
     7201 ccaaccggtg tgtgaacgtc cgccggcagg gtcacggcca cgggaacgac ggttgcttcc
     7261 tgggccagcg ccaggaaggc atcgtatgtt gccggctgaa attgcagcgt ggacacggtg
     7321 gactcgctcc ggggcttact ccgtgggaag aggtcggcgt ttgccggcgc ggctgcgcag
     7381 aatttcggcc acgtcgtggg gtgtcacatc ccgcgccacc atcaggacga gcaggtgata
     7441 gagcaggtcg gccatttcag cggccaactc catgcggggt tcatttttgg cggcaatgat
     7501 ggtttcggcc gcttcctcgc cgactttttt gagaatcttg tccagcccgg ctgtaaacag
     7561 ataggtggtg taagcgcctt ccgggcgttt tgcctggcgt tcccggatca gggcatacag
     7621 ctcatcgagc aggataccca gttcgagcgc actgtggggg acgagcctga cttccggcgg
     7681 ggcaatggcc gtcgttccgt cgggggcttg ggctgccggt ggaccttcat ccgttttggc
     7741 ggtagtaccg cttggaagca gggactggaa aaaacagctc gtggctccgg tgtgacaggc
     7801 cggcccacgc ggttcaactc tgacgacgag ggcatcgccg tcgcaatcca gccgtatatc
     7861 cacaacccgt tgggtgtggc ccgacgtggc ccccttgtgc cacagggatt gacgcgagcg
     7921 gctccagagc cagacctcac cggtttcgca ggtgagttgg taactggtgg cattcatgta
     7981 ggccagggtg agcacctcgt tggtcgtggc atcctggatg acgaccggca cgaggccgtt
     8041 ggcatcgaaa cgaatcgctt ccgtcatggc ttggttacgg caacacgtta ccggcgttgt
     8101 agcacagttg actggtctcc tgacaccctg ccggcaactc ccgtcgcaaa ccggggcaac
     8161 aaccgtctaa ccgtggcgcg ccaggacgta atcacagacc tcgtccagtc ggcagaaact
     8221 gtttggaagg gaaaggcggc ggatgggaac gactgtggcc agttgggtca gcgtatccag
     8281 aatggcaacc cgcgcttccg gcaggggaag ccagtcggga tagatgttgg gcaggagctt
     8341 tgtcacagcc tgcatcggag agagctgcgt actgctgacc ggagcctccg ccggaacgac
     8401 ctccaggagg tacacggccg taagccgtgc cggccggggt tgttcagggg tatcgagagg
     8461 caggtagcgt ttttcccagt gtttggagat gcagggaagt gcgtcggggc ggccgtaaag
     8521 ggctgtgaca gaagggtccc acaagcggat ggcacgcggc cccggatgca ccacaaagcc
     8581 ctccgcctgc cgttcgatgg cggccacatc ctcggcgatg acctctgcgc cacgccggag
     8641 cagtgctgct gcaagtgtgg atttgccggc gccgttcggt cccacaaagg ccacggctga
     8701 tgtacccatg accaccgtgc tggcgtgcag gcacacccgc tgctgaatct ggagaacaaa
     8761 gcccagaatg gggccggtca ggtaggtaca ggtatcctca aacgtctgcg gcggtgacca
     8821 gagcgccgtg atacggcgtt gagggtggtc gtaggtgaaa gccgtgccga cgttatagca
     8881 aaagtgaaac agaccgcgct ccggctcatg gtagccaatg agttcggggc cctgcctggc
     8941 atcgacaatt tgcccctgat accacggtgc acacgccggg gggcgtggtg tcgtaggcct
     9001 ttcctcaaag gcaagaaagc catcggctgg gtcttcacca aggtgcaccg gctggagaaa
     9061 aggcaccggg cgggtcgtcg ccagtcgccg tccataaacc acctgcgcca gtgccatccg
     9121 gggagacact caccgtgaga aacggtttgg gcgggggcca atccggtccg ccctggttga
     9181 gccaacactg ttccgggtgc attcaacaag tgacccgtaa tcagcgagca tcggcggctg
     9241 gtatgccttt ttgcccggtt gcccggtttg tgatggacct gtggtttgtt cgcgtggcag
     9301 tgaaggctgt ttcataagcc agtctccaaa cggcaaaagc acaatagatt tggaaagttt
     9361 atacaacctt ggattgtaac catttgtata agcttggcag gttcaggtca acaaaagatt
     9421 gggtctcttg ctgtccatcc tgcacagtgg ggcaaggctt cgacgtttac gaaacaacca
     9481 ggttggcagg cctatggggg aagttgcacc cagcgtactt ggcgtgctta cgccctcagt
     9541 gccagatgaa gagtaaagag tgtcacagaa agacacctca cccaggtttg gcttttgcag
     9601 gttgccctga atgtcaagat gcctgccaat gaggcatggg gctttcctgg gggcaaaaag
     9661 gcggttcggc tctgtcttca accaaggggc accggctgga gaaaagggac cgggcgggat
     9721 gtcgccagtc gccgtccata aaccacctgc gccagtgcca tccggggaga tgctcacact
     9781 gagaaacggt ttgggcgggg gccaatccgg tcagccctag gtgagccaac actgctccgg
     9841 gtgcattcaa caagtgaccc gtaatcggcg agcatcggcg gctggtatgc ctttttgccc
     9901 ggttgcccgg tttgtgatgg acttgtggtt tgttcgcgtg gctgtgtagg cggtttcata
     9961 agtcagtctc cgaatggcaa ggcacaatag actggaaagt ttataaaact ttggatcgca
    10021 gccagttgta caggctgagc gggctgaggt caacgaaaga tttggcctcg tgccgcgcat
    10081 cccacacgag cgggacggcc aaggcttcga tattcacaaa gcaagccaga tggtggcggg
    10141 cttccggggg cagttgcgcc cagcctgtgc cgtgccgcct gatgtagccg gtgacgggaa
    10201 actgaggaag gggggccttg gcgcgtcgga cgacggcgcg tgggagccgg tccctgagca
    10261 gttcccggaa aagccacttg tccaggcaaa ggggcacggt cggcgccgcc aggagaaacc
    10321 cgataaggcg ctggtcaagc agcgggtagc gcatttccac caccgcgccg gtaaaagcca
    10381 tgtcgctgta ttcgtggtca ttggcgatgt gaacccgact cagcatctgc ggcacgagcc
    10441 ggcggtaggg gtgcgggggg ggactgggct gcgggcgctc gaaataacca gcccggcaca
    10501 ggcgcgtcac aaaatccgtt gccagccagc ggggtatttc ggattgggtc gggtgctttc
    10561 gtccgaacct tcgtctgaac tgacgccgaa gcgaaaagaa gctgttgcgg acgtcagcca
    10621 caaggtatgc cacaagggcc ttgcccagac ggatgaactg ccgccgggca acgaggtcgc
    10681 gcaggcaggg cgctgtttcc tgaagcatga cttcatcgcc ccactgcccg gtcaggatca
    10741 ggcgggcgtg actccccgcc tgacggtaac tctctgtgat gccattccag aagggttcgt
    10801 gaaccggctc aggtggtagg agaacgccgg ctgggtgggg cgcatacggc tgccagtcat
    10861 catgctcaac gaaggtaatg gggatgccgt ggccccgggc ggccagaccg gcgaaatgcc
    10921 gttcacggtc gggaatgagg atgttgaaaa cattggtgaa ggcgcgcagg tcggtcgtgg
    10981 ggcaggcgcg ccgtgcggca gccgtcacca cgttggaatc cagcccaccg ctgaggaaaa
    11041 cagacgcgcg tggcgcgcgc agccggtcag ccacagcctg ttccagaagc gcctgaaagt
    11101 gctcaatgta atcactcgtg cgggcatagc ggagataccc atcggtcggc caatcccagt
    11161 aacgccactg ccgccgtgcg cccccttcga gacacagcgc cgtagcccgt ggcaggcggc
    11221 ggatggcgcg gtaaaacgtg ccgtcttcgt ccagcttcat cccttcgatg agaaaatcgg
    11281 caatggcgaa gtcgtccaga tcggccggga gcgacgccgg aatctccggg tgggcacaga
    11341 tggtctcaag gtcgctggag gccacgaaca gccccggctg gtagctgtaa tagagtggtt
    11401 tgacggcaaa cgggtcacgc gcgcagaaca gccgtcggcg atgggcatcc cacagggcaa
    11461 aggcgaagtc accctgaagg tggcgcaggc agtccaattc ccagagacgg tacgcctgcc
    11521 agagcagtct ggcatccggc atatcctggt cggcctctcc accggctgcc tggatggcac
    11581 ggcagagttc ttcccgtgca tccagccgga tgtcggctgc aagccacacc tgtccgtcga
    11641 acgtcagcgg cggtgggacg cgcgtcaggt catctacccg gagatgggca tagcccaacg
    11701 ccacgtgagc gtccgtccag tgggattgac cgtcgggccc gcgccaggcc aaccgctgga
    11761 gcaaccgtgc ggcaagcggc ggctcaaccg gccggccgtc gggatggaag ataacgaaaa
    11821 agctgctcac gaggcattga gaggcgtatc aaagacggca taacgctgcc gtacgtccgg
    11881 ggattccatc accggctggc cgcgccattc cacccatgca tgggcttcaa acgtctgggc
    11941 gtctttctca acacccagcc ggaggtcaca gacgatgccg cgtcgggcca gcaggaacca
    12001 cagcacaacc gcacggatga ggcaggttgg cgaccggggg caataccgga ccgcccaagc
    12061 gacaagaaca ccctggtgat ccacccactc cgccaggcag gttgcggatg atgccggtgg
    12121 cggctgacgg ccaaccatcc actgcatcca ccgcaggcag gcgcgtacgc cgacgaggcg
    12181 gcacagtccg ggcaagccca gcaacaaaag ccatgctgtt accagacttg cccggtcttc
    12241 cgatggaaga cggcagaaga tatgcaggcg gtacagccaa cgtttcatga gattggagct
    12301 gcctctggcg gcgaatctga agaaaccggg tccggcggaa cgatctcaat cagatcagct
    12361 tgccgaagct gctccagcag ggtgttgaaa tcctgctgaa gccgttccgg ttcgacttca
    12421 tattcgtcca gcagagccgc cagagcgtct tgcaacgtcg ggcaactggt ggcctgtcgc
    12481 agcatgctgt aggccacact atccagaccg tagtaatgct ccgtgaccag attgagcagg
    12541 atggcctcat cggcaacgga gcgaacgatg acgtgcttgg gaatcagggc gcggttcata
    12601 agggaaagca tcgttacgtc agacaggtgc gggattggaa acatctggct ggcgcctatc
    12661 catcgggagc aggcgccatc acggggttaa atgtgcaagc caatatactt gttcgctggt
    12721 cggagcgcac gtactctcaa agagattcca ctcctgtttg aagccaaagc caatgtactc
    12781 tgactacgtc accctgactt accatgcttc actgattgcc gacgagcgtc gggttcagcc
    12841 cttccagtct gccatcgagt ctgtcgtgcg ccccggcgat gtcgttgccg acattggctg
    12901 cgggacggga attctgacgc ttctggcgtg ccgggctggc gcccggcgtg tctatgccat
    12961 tgacgagggc cccatcattg agcttgccag gctgattatt gagcagaatg gttatgctga
    13021 ccgcgtgaca ttcatcaatc acctgtccac ccgcgcccgg ctgccggagc cggtggatgt
    13081 catcatttcc gagaccatag gcaactatgg cgcagaagaa cgcattctcc cgacgctccg
    13141 ggatgcctgt cgccgctggc tgaaaccagg cgggaagctc attccgcagg caattgaact
    13201 gtactgtgca cccatcacct ggccggaagc tgagccggct ttgtccgtct ggcgtcagcc
    13261 ggtgtgtggt tttgattttt cgtctgcgct gtccttcgcc gtcaaccagc agtattcaca
    13321 ccgtttgggt tcgcagcatg tgctggctga agggcgctgc tactgccggg ttgacctgac
    13381 cccggcggtg ctgcgtggtg atgccctgcc caaggtagcc gggacggtat cctttcgggt
    13441 ggcacagcca ggggtgatgc acggcatcgg cgggtggttc aaggcgtggc ttgctgaaga
    13501 catcacgctg acaaacagtc cctacgagcc gccaaccagt tggggacatt tgtgcttacc
    13561 gattgccgag ccgctgccgg tggccgttgg ggatgaagtc gaagtgacgc tccgggcggt
    13621 tggcggcggc agcgtgctgt gctgggacgt gacctggcgc ggtgttgggg gagcatccaa
    13681 gacgttccgc cattccgatt tcgagggctg gctggcaacg ccggaacgcc tgcggccgct
    13741 gtcgcccacg gcggcgccgg ggctgggggt ggaaggcaaa atgcaacttt ttctgctgac
    13801 gaagctcgac gccggctgga cggttgagca ggtcgcccgc gggctacgcg aaagtttttc
    13861 ttccgagttt cctacagatg aggatgctct ggtctatgtg aaaaggcagg cgctgaagtt
    13921 cgctcgttga ggcgtaggaa gccggaagtg cgtccagact ctccgttatc cagttcgatc
    13981 ggttgacctt ctccgtagcg gtcgctgaga accacgcgaa agccaagggt tgtcagcaat
    14041 tcttcgcggt gcagcccttc ccggattgag cagcggcagc catcgggcag tgaggcccac
    14101 gagccacccc ggatggtacg gtgttgcgcc cattcttcct ggcggatgtt ccgcaccggc
    14161 gcgccctgtg cgtgaattcc cgtcaggcgg gaagtatagg tgtccaggca ccactcccgt
    14221 acgttgccgt gcatgtcggc cagtccgaag gcattgacgc ccagcgatcc ggccggcgtt
    14281 ggctttttgc gtggctggga cgccggctcg tcccggtagg gtagtgaccc atcgtagttt
    14341 tcaagcgtcg gcagcagaac cgcgccgtag gcaaacagtc cggtggcgcc agcccggcag
    14401 gcatattccc attcggcttc ggtgggcagc cggtaggggc ggccggttct cctggtcagc
    14461 cgccggcaga actcgacggc ttcatcccag gtgatgctgt ccacggggag gtcgtcgccg
    14521 gtgtacttcg atggggaagg cggcaggtca cgttcgactt tgggccagga tgcgacttcc
    14581 cgccactgcg cctgggtgac ttcggtacgc cccatgtaga acccgaggac ccgcgcgcgc
    14641 atcggcggac gctcattgtc atagctttcg ctttcatcgg agaccgtgtt gcccagggtg
    14701 aagcagccgc ccggtacagc caccagttcc agcgtcacct ggttgcccag gttttcgaca
    14761 aaccgttgcg tttcgccttt gacggtctcg acgacattgc ctttgtcgtc cagtctggga
    14821 gattcaaagg tgacggtgga aagctgttcg gctggaagcg ccacggttgg cgccagcggc
    14881 ccggacggac aggggacagc cggtggacgc gcgcccgtgc cctttccgcc actacgtcca
    14941 cgcccaccgg ccggcggaga tgtcgcttcg ccgccgccca cttttccccc gcccacactc
    15001 gtgctgcgtt cctgcgcagc aacctgggtc acaagtgggg ttggcgtggt catcgcccaa
    15061 agaaatccca gcgccagacc agccggccag atacgccaac ctgttttccg ttgcgccatg
    15121 ttttgtccct cgaagccggg ttgcctcgcc cgtcaatgcc atgacgtgat gcagtgtagc
    15181 agctttggga ttgcccgaag aacacccctg ccggctgaac agacattttg gttatggatg
    15241 ccgtgtgaac gtgactcact tgatgcgcca gggaagtccg gctacgacga aatagacttc
    15301 cgttgccgct gcggccaccg actggttgac gttccccagc aggtcccggt agcggcgcgc
    15361 cagggcgttg tcgggaacaa tccccagccc gacttcattg gacacgacga tgaccgtctg
    15421 ctcacggcgc gaaaaggtct gcaaaaaggc cgccagcgtg gtttccagcg cattgaggca
    15481 ctgtgcctca tcgtgcggca tagccagcag ccagttcgag acgagcagtg tcaggcagtc
    15541 caccaccacg acaccggctt ccgccgcctg ggcgtaagct gccgccagcg cgcgcggctc
    15601 ctcgatggta cgccactccg ccgggcgttc ggcccggtgg cgcagaatcc gcccctgcat
    15661 gtcttcgtca agggcttccg ccgtggcaat gaaacacacg gctgcgccgg tggcgtcggc
    15721 tttcgtctgg gcaagctgct gggcaaaccg gcttttgccg gcccgtgcgc cgcccagtac
    15781 cagaatgagt tcgcgcgtca tcaggcatcc gtatccagca tgggaagcca caggccctgc
    15841 gccctggcac actccacggc atcggcatag ccggcatcag cgtgccgcat cacgccggtt
    15901 gccgggtcat tccacagtac ccgttccaga cgccggtcag cggcttccgt gccatcacac
    15961 acgatgacca tcccggcatg ctgtgaatag cccatgccaa cgccgccccc gtggtggagt
    16021 gaaacccacg tcgcaccgct ggccgtgttg agcagggcat tgagcagcgg ccagtcggaa
    16081 accgcatccg agccatcccg catctgctcg gtttcccggt tgggggaagc caccgaaccc
    16141 gcatccaggt gatcgcggcc gatgacaacg ggcgctttga gttcgccctt gcggaccatc
    16201 tcgttgaacg ccagtcctgc ccggtggcgt tcacccagac ccagccagca gatacgcgcc
    16261 ggcagtccct gaaaagcaat ccgctgttca gccatcgtca accagcggtg caggtggtcg
    16321 ttgtcaggaa acagctccat cagacgccgg tcggtgcggt ggatgtcttc cgggtcgccc
    16381 gacagcgcca cccaccggaa cggccccttg ccccggcaaa acagcgggcg gatgtaggcc
    16441 gggacaaagc ccggaatcgt gaaggcatcc gtaacgcctt cgtcaaaagc gacctggcgc
    16501 aggttgttgc cgtaatccac caccctggcg cccaaggcct gaaagtcgag catggcccgg
    16561 acatgccggg cgcaactttc cgccgctgcc tggcgcagcg tcccgtgctg tgccgggtcg
    16621 cgttgggccg cctgccactg ttcaaccgtc cagcctgccg gcaggtagcc gtgaatcagg
    16681 tcgtgcgcgg ccgtctggtc ggtcacgatg tcaggacgtg gccccccctg ccgggcgcgc
    16741 tccaccagcg ccgggaggat ttcagccgca ttgccgagca gtccgacgga aaccgccttg
    16801 ttctccgccg tgtaacgttc gatgcgccgg agggcgtcgt cgaggttgtc cgtccactca
    16861 tcgaggtagc gcgtccggca acgggcttcc atccggctga cctggcactc gatgaccagc
    16921 gccgctgctc cggcaaacac cgccgccaac ggctgcgctc cgcccatgcc gcccagcccg
    16981 gccgtgagca cccagcgccc ccgcaggtcg ccgccatagt gctgccgtcc catttcggca
    17041 aaggtctcgt aagtgccctg cacaatgccc tgggtgccga tgtaaatcca cgaaccggcc
    17101 gtcatctgcc cgtacatcat caggccgcgc cggtcgagtt cgtcgaagtg ttcccacgtg
    17161 gcccagcgcg gcacgaggtt cgagttggcc agcaacaccc gtggggcatc cgggtgcgta
    17221 cgaaagacgc caaccggctt gcccgactgg atgagcaggg tttcatcttc tcccagccgg
    17281 cgcagggtgt cgccgatggc ttcaaaacac gcccagttgc gggcggcttt gccggccccg
    17341 ccatacacga ccaagtcttc cggtcgttcg gcaacttccg ggtcaaggtt gttgtgcagc
    17401 atgcggtacg ccgcttcaat ctgccagttg cggcatgaaa gttctgcccc acgtggtgcg
    17461 cgaaggattc tggtcatggc gagacttcat cagaaaacaa catccggcgc gccgatacgc
    17521 gctgccaacg acgttagtgg ggtgtccaga tggcgtcaag ccgctgcttt tcagcacgca
    17581 atgcgcaaag taggatgcgg cttgcgtgaa acgacaacag catgttgagg gggcaggcag
    17641 aagatgttgg cgctgtggcg caacgcgcga ttggcgacgt tggcaaaccc ggacgcctgg
    17701 ggctggattg aagacggcgc catggtcgtt gccggtgaat acctgcactg ggtcggtgaa
    17761 acgcgccacc tgccccgcag cctgccgatt gccgaagaac acgacctggg cggcgcactg
    17821 gtgacgccgg gacttgtgga ttgccacacg cacctggtct atggcggaac gcgcgccgat
    17881 gagtttgaag cccggctgca cggcgcaacc tatgccgaca tagcgcggca gggcggcggc
    17941 attctctcca ccgtaagggc aacccgcgcg gcttctgacg acgaacttct ggcggccgcc
    18001 atccgccgcg cccgcgcact tctggcagaa ggcgtcacga cggtcgaaat caagtccggg
    18061 tatgggctga cctgtgctga tgaagcccgc tgcctgcgca ttgcccgcca actggcgcag
    18121 cgcctgccgc tgacggtctg cacgacttac ctggctgcgc acgccctgcc gccagagttt
    18181 gccggtcgcc cggatgacta catcgccgaa gtctgcgcct ggctgccgga ggtgcacgcc
    18241 gccggtctgg tggatgccgt ggatgccttc tgcgaaaaca tcggtttttc ggtcgagcaa
    18301 acgcggcgca tctttgaaac ggcctggcag ttggggctgc cggtcaaact ccacgccgaa
    18361 cagttgagtg accagggcgg ggcgttgctg gcggctgagt ttggtgcgct ttcatgtgac
    18421 catttggagt atgtcagccc ggccggcatt cgcgccatgg cgcagtccgg cacagtggcc
    18481 gttctgttgc ccggcgcgtt ttactttctg cgtgaaacac aacgtccgcc ggtagccgta
    18541 ctgcgggccg ccggcgtgcc aatggcggta gcgaccgacc acaatccggg ttcgtcaccg
    18601 acactctccc tgctgctgat gctcaatctg gcctgtacgc tctttcagct tacgccggaa
    18661 gaagccctgc gtggtgttac ggtccatgcc gcgcgggcgc tgggacttgc cgaccggggc
    18721 atcctggcgg ccggcaggcg ggcggatttc gtcgtctggc cgctggcgca tccccgtgaa
    18781 ctggcctact ggtttggtgg ctgtcatccg cagcaggtga ttttgggagg aaaagaggtg
    18841 gtgcgtcatg gcgtcatcgt cggttgaacc ggtatttgaa ctccatccgg gtgatgttcc
    18901 cgtgctgatc agcctgccgc acgtggggac ggttgtgccg ccggagattg ccgccgactg
    18961 gactgacgaa gcgagaaccc tgcccgatac tgactggcat ctgggtgaac tctacgcctt
    19021 cgcccgccaa ctggatgtcg gcatcctgca ggcgcggctg tcacggtacg tcgtggacgt
    19081 caaccgcccg cccgatgacc tgccgctcta tcacggcaag cactacacgg agctttgccc
    19141 gacgcgcatg ttcaccggag aacccattta ctgcgaaggg aagacaccgg atgcaatgga
    19201 aattgcccga cggcgcgcac attactggca gccgtatcat gacgcgctcg aacaagagtt
    19261 gacgcgcctt caggcgcgtc atggttatgt catcctgtgg gaaggccaca gcatcaagtc
    19321 ccggttgccg tggcttttcg agggaacgct gccggatttc aaccttggca cagccagtgg
    19381 tgcaagctgc gcaccagagc tgcgccaggc gctgtgtgct gcgctggctg cgcaaaagga
    19441 actgacctac gtggctgatg accgcttcaa aggtggctac attacgcgcc attacggccg
    19501 gccggagcag ggacgccacg ccgtccaact ggaaatggcc tggtcctgtt acatgcgcga
    19561 tgaagcgccg ccctatcgga ttgacccgga acgcgccggg cgtctgctcc cgattttgga
    19621 gaaactcatc attacggcgc tcgcctggag tccgtcatga cgcttgagcc ggtcccgccc
    19681 aaagctctgt ggacaccctt ggcctggctg ccccacggct ggcaacgcca cgtcctgctg
    19741 accattggac aggatggttg ctgggcggat gtggaaacaa atgtgctgac gcctccgccc
    19801 gaagctgtgc cacttgcagg cgctttgctg ccgggtcttg tcaatgccca cagccatgcg
    19861 tttcagcgtg cctttgccgg actggccgaa accaccacgg gcgaacagga tgatttctgg
    19921 tcctggcgaa gccgcatgta ccaccttgcg gcgcgcatca cacccgaact tctgcgcgcc
    19981 atcgcagcac aactttacct ggaactgctc cggggcggat atacccaggt ttgcgagttt
    20041 cactatctcc accgcgatgt atccagcgaa ccttatcccg aaccgctgac gatgctggaa
    20101 gctctcattc atgctgccga agacgttggg atcgggttga cgctgctgcc caccgtgtat
    20161 gagcgggccg ggttcggaca gcctgacctg ctgccagagc aacgccgttt ttttgccaca
    20221 cctgatttcg tatgggaggt ggtcaaagct gtggaggcag gcaatcgtcc cggcatccat
    20281 gtcggtctgg cgctacattc cgtccgggcg gtgcgcccgg aaagtttcga ccacctgcgg
    20341 cggctggctg aggattttac cgggcctatt cacatccatg tggccgagca ggtggcggaa
    20401 gtcgaagcct gcctgcgcgc aacgggtgca cgtccggtcg cctggctggc gcgtgagggg
    20461 tatctcgatc cccgctggca gcttgtgcat gccacgcata ccgatgccgc cgaacgcgag
    20521 gccattgccc ggagcggggc cggtgtggtg gtctgcccga cgaccgaagc caatctgggt
    20581 gacggtttcg tggacctgcc ggcctgggcg gaacttggcg taccgctggc catcggctca
    20641 gacagccacg taaaccgcga ctggcgcgag gaactgcgct ggttggtgta cagcacgcgc
    20701 ctgttgacgc agcgccgggg gattgccgga ctaccttcgc cggcggccag cctctttgcc
    20761 ggagcgcaac tggccggcgg tgatgcggcc ggtctgccga actgggggct gacgcccggc
    20821 gcgcgcgccg atgcgctggt gttagcaaca ggcgccgcgt cactgatcgg agccacgccc
    20881 gaacacctgc tcgaagccgt tgtgttttca agtccggggc cggcctggtc agacgtgttc
    20941 gtagccggcc gctggtggct gcaacgcgga cgccatcccc gccagggacg gattcaggcg
    21001 cgtttcaggg cagccatgga aacgctgtgg gcgtccgccc gtccctgttc ccggaacacg
    21061 gagccggacc atccgcccca gccctaactg gcccgcatcc ggcgctgtgc catggctttg
    21121 gcatggtagg cccgaaaggc tgcggcttcg gtgcggccca tgtagcgctc cagcgtgcgg
    21181 aggtcgctgt cgagcaggtc caccatgatg aggccgtcca gtgcgtcgcc gaagtccggg
    21241 tcaatgttga atgccagcac tttcccaccc agcttgaggt actgccgcag cagcaccgga
    21301 acgcccttgg catccggctc gatgtcggcc acaaaggccg agacttcctc gatgtcagcc
    21361 gccgaaatgg tggccgattt gagtccgagc agggtttgtg ccatggcgag cgggcgggac
    21421 tcgaaaggcg tccgtggacg gaccagccgg gccagttgcg gctgaaagct gttcgccttg
    21481 agaaactcca ccatcagccg ccgggaagcc gcgcggtact cattggtaat gcttaccggg
    21541 ccgaacagca cccggtagcg cggatgctgc acgacatagc gcccgatgcc tttccacaac
    21601 agcatcagcg gcgcatagct tttctggtac tccgggcgga cgaaggaacg ccccagttcg
    21661 agtgccggcc cgatgctgcg cagaaaggcc gtgcggtagg caaacagggt gtaggtgtaa
    21721 agtccacgct tgccgaagcg ggcgaggatg tcatccgtcc gcccaaaacg atagccgcca
    21781 acgacttccc gccgctcctg atgccagatg aacaggtgct ggtagtaggc atcgaagcta
    21841 tccacatcga gtgccttgcc ggtgccttcc ccggcggccc ggaaggtgat ttcgcgcagg
    21901 cgtccaatct cgtgaagcac gtgcgggatt tgctcggcgc ccgcgcacca gaccgtcaat
    21961 tcgccctgtt tgaccagaca ggcggtttcg ggaagcgcgt tgatttcagc ttccagcagg
    22021 gcggctgcac gtggcagcgc aatcgccgcc ggcacaggct gcggacgctg aaacgacggc
    22081 atcgggagct tcggaaaact tttcggcaag cgtagtggcg cggccagcgc ccgtggcagc
    22141 cgtgaggccg gttccgtacg ggaagccagc aggtaggtgc gctgccgcag gtgctccgtc
    22201 agggtttcat catcgagggg cttgagtttc gcccagggaa tcgggtgccc gatgcgcact
    22261 tcaatctccc ggttccgttt gttgagaaac tcatagggca gcattgccgt gcgcaggcgc
    22321 ggatgaacga agccggccat ctggaacagc gcgccgtttc tgccgtcaaa atacaccggc
    22381 acgacggttg cctcactggc acgcaccaga cgcgccaagg tgggtttcca ggccgggtcg
    22441 gtgacgatgc gcttgccagc ctgccagtgg gccacctcac cggccgggaa caacccaatc
    22501 gcaccacctt gggcgagaaa gcggagggcc gcccgaaggg ggcgaagatt cgcctgtggt
    22561 gagtttggac gctcaaacgg gtcaacgaga atgaagtagt cgtgcgcttc a
//
