LOCUS       NZ_CP073318            22007 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7893304
            Orig. end                         :: 7915311
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22007
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="redox-cofactor"
                     /region_number="43"
                     /rules="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /tool="antismash"
     cand_cluster    1..22007
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(cds(PF04055 and (TIGR04085 or SPASM))
                     and (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /kind="single"
                     /product="redox-cofactor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22007
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12007](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12007
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(PF04055 and (TIGR04085 or SPASM)) and
                     (TIGR02111 or TIGR03966) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]))"
                     /neighbourhood="10000"
                     /product="redox-cofactor"
                     /protocluster_number="1"
     misc_feature    24..38
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.92"
                     /tool="antismash"
     gene            1216..2142
                     /locus_tag="JJ691_RS34645"
                     /old_locus_tag="JJ691_69320"
     CDS             1216..2142
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697960.1"
                     /locus_tag="JJ691_RS34645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69320"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_211763774.1"
                     /transl_table=11
                     /translation="MGVMRGLRFAAIAAGTLGGLYGAAYGLLTNQARRAERIIGPPVAP
                     PFLADGVYLPDGSGPVPPAEEDSALRFAMFGDSMAAGLGVDGPDQLPAVVLARGLAEEA
                     GRPVRLDTYAVVGAATKDLPAQVEQALLAPPHVAVIIIGSNDVTTLTTVPDAVAGLERV
                     IRALQDAGCGVVVGTCPDLGVIRPIAQPLKSIARAWSLLLAQAQRKAVARIGAIPVALA
                     DLLAPEFLARPREFFSSDQFHPSAVGYDAACSVLLPALCTVAGVWTGGPLPKLPHRSVL
                     AESRRPTARFIARVNFRLGRPARELAP"
     gene            2236..3456
                     /locus_tag="JJ691_RS34650"
                     /old_locus_tag="JJ691_69330"
     CDS             2236..3456
                     /EC_number="2.3.1.9"
                     /GO_function="GO:0016747 - acyltransferase activity,
                     transferring groups other than amino-acyl groups [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005466189.1"
                     /locus_tag="JJ691_RS34650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69330"
                     /product="acetyl-CoA C-acetyltransferase"
                     /protein_id="WP_211763775.1"
                     /transl_table=11
                     /translation="MPEAVIVSAARSPIGRAGKGSLVSIRPDDLAAQMVRAALDKVPAL
                     DPTQIDDLIMGCGLPGGEQGYNIGRVVSVLLGFDHLPGCTVTRYCASSLQSTRMAFHAI
                     KAGEGDVFISAGVETVSRFAKGSSDGLPDTKNPLFADAEARTVATAEHSGGEWHDPRGD
                     ELVPDVYIAMGQTAENLALAKDVSREEMDEFGVRSQNLAEKAIADGFWQREITPVTLPD
                     GTVVSADDGPRPGITLEKTATLKPVFRPDGRVTAGNCCPLNDGAAALVIMSDTKAKELG
                     LTPLARIVSTGVSGLSPEIMGLGPVEASKRALAKAGMSISDIDLVEINEAFAAQVIPSY
                     QDLGIPLDKLNVNGGAIAVGHPFGMTGARIATTLMNSLQFHDKQFGLETMCVGGGQGMA
                     MVLERLS"
     gene            complement(3474..4799)
                     /locus_tag="JJ691_RS34655"
                     /old_locus_tag="JJ691_69340"
     CDS             complement(3474..4799)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018331691.1"
                     /locus_tag="JJ691_RS34655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69340"
                     /product="hypothetical protein"
                     /protein_id="WP_211763776.1"
                     /transl_table=11
                     /translation="MTGRPMRWKTIRPTFVLPQLKKLSVRSRVALGAPALAVLAAAVAV
                     VASVAVQGDPQLAANQADIANPDCVLQVPANPLSAKGLATPYLISAAKGHCTETNADQS
                     AFVQATILDPATGKLSVYDPLVIDKGSRPEIAPTPPPLPSGAVVGIWFGFNGTNLTLRG
                     DTGTCVNGDNNSVFGQYAYCNAQPFFAAADKAIAGKKLAIPALGAGKDGKPCMTTRDFG
                     LVDQDQSDNVTTTYLQAKDGRIAQDTPANETKLGKAKVHPKTKAKVVAKLNNGSDNVLL
                     DAFVDPALGCTPFTAPDLASGKQVTSLALDELQAAARQQAPIALVPTNDPMVLDGTKTS
                     VTKTNLYRVGVDMPAINPRTETPQAYCRSLVTTGLQRTKLDERFTKTGPSPDPGAASNL
                     FTFLAQRLQGSFDNLGCGNLLHTANPVHLTTNKAGVVVDAGL"
     gene            complement(5095..5883)
                     /locus_tag="JJ691_RS34660"
                     /old_locus_tag="JJ691_69350"
     CDS             complement(5095..5883)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005459152.1"
                     /locus_tag="JJ691_RS34660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69350"
                     /product="Bax inhibitor-1/YccA family protein"
                     /protein_id="WP_211763777.1"
                     /transl_table=11
                     /translation="MRTSSNPAFRALSGKGQGQGGYANFGYQGQQPTGYGYPAAPPTAA
                     DRPMTIDDVVTKTATALGTTIVVGGVTAYLGLHPLFALAAGLVGMVLAFVITFRQSTNP
                     ALVLTYAAVEGVFLGTITKVIDYLVPGVAVQAIVGTLVVFATMLVLYRTGAVKVTPRLT
                     KWIIGATMGAFALVVFNLLLSLFHVDLGVRGNGPLAIIVSLLFIGIAAFNLLLDFDQAD
                     RAIRAGAPARFAWYIAFGLMVTLVWLYVEILNLLAQLQRN"
     misc_feature    6019..6034
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.33"
                     /tool="antismash"
     misc_feature    6023..6041
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.29"
                     /tool="antismash"
     gene            6241..7668
                     /locus_tag="JJ691_RS34665"
                     /old_locus_tag="JJ691_69360"
     CDS             6241..7668
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631478.1"
                     /locus_tag="JJ691_RS34665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69360"
                     /product="SpaA isopeptide-forming pilin-related protein"
                     /protein_id="WP_249227201.1"
                     /transl_table=11
                     /translation="MGLSKLVAGVTGITMLVAGLGVLAAPTASAAVQTGSGLNVPKQPY
                     KGSPANDPNDWLGQYIVGGKAAYCVRFALAAPDSGAKYDPDGDLTDKWGGAIDPTKLAE
                     VSYILLRYGDTTGLAKDVGDAQAAAVAHILHSITSGGRPANPNDGPNEVAYDTALHLKE
                     LPQAAQDDVAKIQTDAAANYGPWKATVTPPTAAQVIGTADKWTINVVRDGGDGAAIKGV
                     PVKLTVTDGKVDSDTVTTPADGSPLVVNVTPTGPNPTVKIDLDAPLAKPTVQKPENQPA
                     NFQWTVFTGGQGAITSTGKTTATTAPGSVKVTKVDSKTGAGIANVQLRVTAADKTAAAV
                     KQDGSPLNGTDGKPLVVTTGADGTATVDGLKTPQDICIIEVAAPAGYDQNFDASSPPNA
                     CGSIQAGQTLALKVANTPNTPTVPVKIPAGGSPMVADAATVTTLDPAALAAVGGLAVIG
                     LGGVGLLLRRRRHASRG"
     misc_feature    6267..6282
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            7661..8422
                     /locus_tag="JJ691_RS34670"
                     /old_locus_tag="JJ691_69370"
     CDS             7661..8422
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016119.4"
                     /locus_tag="JJ691_RS34670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69370"
                     /product="class F sortase"
                     /protein_id="WP_211763778.1"
                     /transl_table=11
                     /translation="MAKHRAPKTRWPVSAGGFPVAGRSRYRNPTAAAGTAVSGAVGLTM
                     IVMAAGATLLGQPQSVPGSPLPVGHSQTVDPQAGPAPVAAPATTTSSAAAPPPAATQQT
                     PQPPAPNTILLPKGGRSSLVRSGVAGDGTLQIPNGVTKAALWGAALDGPAGATLIAGHI
                     NWDGVAGPFAELWGAQAGQDVTVVDGDGKQLKFVVDQVLTVDKDNLPQHADELFGQTGA
                     HRLVLVTCGGKWVGGALGYDQNRVVIAHPVS"
     gene            8460..9641
                     /locus_tag="JJ691_RS34675"
                     /old_locus_tag="JJ691_69380"
     CDS             8460..9641
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012783319.1"
                     /locus_tag="JJ691_RS34675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69380"
                     /product="polysaccharide deacetylase"
                     /protein_id="WP_211763779.1"
                     /transl_table=11
                     /translation="MGLRQRWGWLTTAVALALAVVVVIVMGQGTGSGGTTPAGATTTTN
                     PGPITPAGQATPAAGPTPTLPAPTGAQPAWMHKLKPGEKPPQFILFSFDGGASKDHWSR
                     VLPIAERTGAKVTAMLSGLYLIPDSEKNSYTGPGHPNGASEIGFGGSDADIKLRVDYLN
                     RALDDGMEFGTHYNGHFCQGAEPSVGFWSTAGWNSELDQFFSYLKEIDGKGLRITPDMI
                     KGGRTPCLEGNWDQLFPSMKSHGFVYDTSHVSFGVTWPTVDRGLWEFPLPEVRVPALDK
                     NVVMMDFNFWYLLDGAKEGDDARGPEFTPIVLDTYRSVYQTVFNGNRAPLVIANHFNDW
                     AGGAFSGAVEQFMSETCGKPETVCASYSQVIQWMQLQDPATLDALRSLPAAHN"
     misc_feature    9714..9725
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.52"
                     /tool="antismash"
     gene            <9833..9910
                     /gene="pqqA"
                     /locus_tag="JJ691_RS53125"
                     /pseudo=""
     CDS             <9833..9910
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020387832.1"
                     /locus_tag="JJ691_RS53125"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="pyrroloquinoline quinone precursor peptide PqqA"
                     /pseudo=""
                     /transl_table=11
                     /translation="RRSWVKPDFNEYDTPMEVTAYSARV"
     gene            10001..10675
                     /gene="pqqC"
                     /locus_tag="JJ691_RS34685"
                     /old_locus_tag="JJ691_69400"
     CDS             10001..10675
                     /EC_number="1.3.3.11"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR02111"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336983.1"
                     /locus_tag="JJ691_RS34685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69400"
                     /product="pyrroloquinoline-quinone synthase PqqC"
                     /protein_id="WP_211763781.1"
                     /sec_met_domain="TIGR02111 (E-value: 5.1e-83, bitscore:
                     277.3, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLAAEDFIAELRALAPRYWHDHPFHLRLHAGDLSREELQRWAANR
                     WYYQRSLPQKDAAILANCPLSQVRRYWMERIVYHDGSRDGEGGAENWLRMAEAVGLDRA
                     EVLDERHVLPGVRFAVDAYVNFARSKPWVESIASGLTEMFSPGLMKRRLADMREQYPWI
                     GEDGFAYFVSRLTVIAGEGKSTLDIVVEHARTREQQQACVAALAFKCDVLQAILDAVDY
                     HS"
     gene            10672..10938
                     /gene="pqqD"
                     /locus_tag="JJ691_RS34690"
                     /old_locus_tag="JJ691_69410"
     CDS             10672..10938
                     /GO_function="GO:0048038 - quinone binding [Evidence IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336984.1"
                     /locus_tag="JJ691_RS34690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69410"
                     /product="pyrroloquinoline quinone biosynthesis peptide
                     chaperone PqqD"
                     /protein_id="WP_211763782.1"
                     /sec_met_domain="PqqD_RRE (E-value: 1.2e-19, bitscore:
                     69.1, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.1e-10, bitscore: 39.0,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLDSVPRVRRGVRCTYDKTRDSDVVLFPEGVLLLNETAAAVVF
                     RCDGSASVGDIALALADEFDGVQPDDVIELVDRLVARRVVDVD"
     aSDomain        10678..10929
                     /aSDomain="PqqD_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing protein in a pyrroloquinoline
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JJ691_RS34690_PqqD_RRE.1"
                     /evalue="3.10E-22"
                     /identifier="RREFam006.1"
                     /label="JJ691_RS34690"
                     /locus_tag="JJ691_RS34690"
                     /protein_end="86"
                     /protein_start="2"
                     /score="69.1"
                     /tool="antismash"
                     /translation="SLDSVPRVRRGVRCTYDKTRDSDVVLFPEGVLLLNETAAAVVFRC
                     DGSASVGDIALALADEFDGVQPDDVIELVDRLVARRVVD"
     gene            10931..12007
                     /gene="pqqE"
                     /locus_tag="JJ691_RS34695"
                     /old_locus_tag="JJ691_69420"
     CDS             10931..12007
                     /GO_process="GO:0018149 - peptide cross-linking [Evidence
                     IEA]"
                     /GO_process="GO:0018189 - pyrroloquinoline quinone
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="pqqE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: TIGR04085"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     redox-cofactor: SPASM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018680417.1"
                     /locus_tag="JJ691_RS34695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69420"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqE"
                     /protein_id="WP_211763783.1"
                     /sec_met_domain="PF04055 (E-value: 2.7e-22, bitscore: 79.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 5.6e-05, bitscore: 22.6,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.9e-09, bitscore: 37.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 2.4e-10, bitscore:
                     39.9, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTEAPLGLLAELTHRCPLHCPYCSNPVELVQRADELDTSTWQRVF
                     DEGRELGVLQVHLSGGEPLARPDLPKLLAHASGLGCYTNLVTSGLGLTAERLAELVSLG
                     LDHVQLSVQDADPRNANLIAGVKGYDRKLAAAVLIKDAELPLTVNAVLHKANLDHIGGI
                     IELAEQMGADRLELANTQYYGWALRNRAALLPTREQLAAAGPVVQEAKQRLAGRMEIVY
                     VVADYHEANPKPCMYGWGARQLTVAPNGDVLPCPAASVITSLPVQNVLRSSLAEIWYGS
                     ETFNAYRGTEWMREPCRSCPRKEIDFGGCRCQAFQLTGDAAATDPVCTLSPDHGLVQDI
                     LAAEITIERPAFAMRRSV"
     gene            12004..12891
                     /gene="pqqB"
                     /locus_tag="JJ691_RS34700"
                     /old_locus_tag="JJ691_69430"
     CDS             12004..12891
                     /codon_start=1
                     /gene="pqqB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098205.1"
                     /locus_tag="JJ691_RS34700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69430"
                     /product="pyrroloquinoline quinone biosynthesis protein
                     PqqB"
                     /protein_id="WP_211763784.1"
                     /transl_table=11
                     /translation="MRVVVLGTAAGGGFPQWNCACSPCALARKGLLPSRSQDCLAVSGN
                     GSDWWLLNASPDIRVQLVGSPEFTPGPGRRDTPLRGVLLTSAELDHSLGVFSLREGGGQ
                     TLYAPANALSALRSNLGLGPVLDNYAGWSWHETVPEQPFELTGELVATAHAVGVKRPKY
                     AGEQPGPWVVAYRIHDPVTGGTLLYAPCLASWSADFEALLAGVDCLLLDGTFCSTDEMG
                     VRTGHTKGQSAMGHLPVFGDGGSLPELRRFPAMRRIYTHLNNTNPLLDPASPESAEIAA
                     AGVEVVPDGTVVTL"
     gene            12967..13611
                     /locus_tag="JJ691_RS34705"
                     /old_locus_tag="JJ691_69440"
     CDS             12967..13611
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007023874.1"
                     /locus_tag="JJ691_RS34705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69440"
                     /product="response regulator transcription factor"
                     /protein_id="WP_211763785.1"
                     /transl_table=11
                     /translation="MRVVIAEDLLLLRDGMIRLLQAHGFEVVAAVESGPELLAALTEHK
                     PDVAVVDVRLPPTFTDEGVRAAIQARREIPGLPVLVLSQYVEQLYARELLSDRSGGVGY
                     LLKDRISDVKQFVDAVRRVADGGTAMDPEVVAQLLSSRERDAPLGTLTPREKEVLGLMA
                     EGRSNAAIAARMFVTEKAVGKHTNNIFTKLNLHQHEDDNRRVLAVLAYLNG"
     gene            13741..15300
                     /locus_tag="JJ691_RS34710"
                     /old_locus_tag="JJ691_69450"
     CDS             13741..15300
                     /GO_function="GO:0015385 - sodium:proton antiporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0006814 - sodium ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0006885 - regulation of pH [Evidence IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639205.1"
                     /locus_tag="JJ691_RS34710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69450"
                     /product="Na+/H+ antiporter"
                     /protein_id="WP_211763786.1"
                     /transl_table=11
                     /translation="MQSVETVLLLVVLATVVATFARRLSIPAPSLLVVAGVVVGLFPGV
                     PEVRATPELVSLVVLPPLIYAAGEEMPWRDLRAVWRPVTVLAVGLVLASAAAVGLVAAL
                     VAPLPASMAFVLGAVLASTDPVAVSALGRRLSLPPRIQVLVQAESLFNDATSLVLFRLA
                     VTAALAGGAVSAGSVGGEFLLLAGGGLGVGLVVAGGIWLIRRRTVDPVLETVIALVSPY
                     SAYVLAETLGGSGVTAVVVCAVVLGAQTPKITTAHIRLQVDAVYGTVIFILESAVFGLI
                     GLQLPYLVRGLAGSDPGWPWQALVITAALIAIRFLWVFPLGWIMQLRRGNRRLNWRTST
                     VVSWAGARGVVPLAAVLSIPLLTDNGEPVPQRDLVLALATTVIVITLVAQGFTLAPLVR
                     RAGIARTPAEARREQDLANVRLAEAGLAHLEQLYDLEAAPHAVLDRLRQGLLARIDHGD
                     PQEEPPGSSVAATYKQLRRELLAVEMAELTRLFDDGEIDDSTRRRLQRTLDLEDARLGD
                     DS"
     gene            complement(15297..16205)
                     /locus_tag="JJ691_RS34715"
                     /old_locus_tag="JJ691_69460"
     CDS             complement(15297..16205)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019474.4"
                     /locus_tag="JJ691_RS34715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69460"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_211763787.1"
                     /transl_table=11
                     /translation="MPSPEFEALLTAIRASPRPEPAAGADGVRQARESMDLALGSIPLA
                     DGVLTGETDAGGCPAVWVRPQGGAMDRVLLYLHGGGYRAGSATAFSGFASQFAAVMGMP
                     VLLPDYRLAPEHRFPSAVEDVVLAYRWLLDEGGYSPGRVVLLGDTAGGGLVVAAMLAAR
                     DLGLPQPAAGACLSPLFDLTASGGSYDKFADDDPIYSRAQALAAAADYLGEANPREPLA
                     SPLFADLSGLAPLMVHAAEREVLVDDARSLVAAVLAAGGRANLEIWPDLMHFWHLFVPD
                     VPESTAAVLGVAEFLLTYIGA"
     misc_feature    complement(16261..16276)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.26"
                     /tool="antismash"
     gene            16412..16873
                     /locus_tag="JJ691_RS34720"
                     /old_locus_tag="JJ691_69470"
     CDS             16412..16873
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS34720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_69470"
                     /product="hypothetical protein"
                     /protein_id="WP_211763788.1"
                     /transl_table=11
                     /translation="MSVAAEKEQTERLLANVEAIEEVAGTLPSGAPGRSKLYDVADNLL
                     DSAMPIRPVVAADLLELTEKTVRAWASEGVLLVSEQEPTMRLEPRRVHEVMHLVREIRR
                     IGRTRGLLDEVHRRLSDQALLERVDLAESLDQVVRGEGTVVRSGTTIPE"
     gene            16870..17316
                     /locus_tag="JJ691_RS34725"
                     /old_locus_tag="JJ691_69480"
     CDS             16870..17316
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS34725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_69480"
                     /product="hypothetical protein"
                     /protein_id="WP_211763789.1"
                     /transl_table=11
                     /translation="MIEVVETRVASAQAALLRGPARKAYESFLDELAHRGCAALGYRVT
                     GPAPLPRLCVRHLRDNDRVVVAFEGAGRAWIVLVGPHEQTDPGRNVYDALYELAGTWPT
                     DNTRRTKPSCCDPNTGTPPSAEAEVIDDLVRRARSLARGSRRIW"
     gene            complement(17414..17791)
                     /locus_tag="JJ691_RS34730"
                     /old_locus_tag="JJ691_69490"
     CDS             complement(17414..17791)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658454.1"
                     /locus_tag="JJ691_RS34730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69490"
                     /product="DUF5684 domain-containing protein"
                     /protein_id="WP_211763790.1"
                     /transl_table=11
                     /translation="MDSTSTSVGGLIVGVIAIVGLWRVFTKAGLPGWGAIIPLYNIYLL
                     MKVAGRPGWWVVLYLIPIVNIIVHLIVSMDVARNFGKSKVFGVVGLWLFNVIGFLILGF
                     GDARYVGERGVAGTGNMAAAY"
     misc_feature    complement(17804..17821)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.95"
                     /tool="antismash"
     tRNA            complement(18204..18277)
                     /anticodon=(pos:complement(7911545..7911547),aa:Leu,
                     seq:taa)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="JJ691_RS34735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="JJ691_69500"
                     /product="tRNA-Leu"
     gene            complement(18204..18277)
                     /locus_tag="JJ691_RS34735"
                     /old_locus_tag="JJ691_69500"
     misc_feature    18315..18329
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.61"
                     /tool="antismash"
     gene            complement(18392..19504)
                     /locus_tag="JJ691_RS34740"
                     /old_locus_tag="JJ691_69510"
     CDS             complement(18392..19504)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015098200.1"
                     /locus_tag="JJ691_RS34740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69510"
                     /product="hypothetical protein"
                     /protein_id="WP_249227202.1"
                     /transl_table=11
                     /translation="MIGAGRAQSDGPPQPMLPARPTPLLLQGQDYVFRAPSGCFDFQEQ
                     IHRLDMVEDSGEPAPCVLVLARSADMEMNELSIALAERGIRMARIDVDRCLDLALTIYT
                     DTPLLELNRWLLRPLLVWRRHFELAAMPVDPRTISGAYALDQWSTVAGWLTERTEWAHV
                     NPARATGHLNRLTQLADAAAFGLRTPRTAVTTQPGRSRPGGGQCIVKTSGRHLVEPRPG
                     VQHGLFPRPLDTARAGDVPEVAPVIVQQYLAADTELRIFVVGERLIGFQVDKYDPAQLW
                     VDPDNVSVKPTDVPCALADRLLALARHWRLQVAAFDLLVVDGEHVFLEVNVNCDWRWFE
                     HRAGSTDVSDAVHEWVAVRFAELLAADRGR"
     gene            complement(19507..19629)
                     /locus_tag="JJ691_RS52980"
                     /old_locus_tag="JJ691_69520"
     CDS             complement(19507..19629)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS52980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_69520"
                     /product="hypothetical protein"
                     /protein_id="WP_255360895.1"
                     /transl_table=11
                     /translation="MSMEDLAAQLRSGEIEDQALAEFAAEYARAERISRSKKDD"
     misc_feature    complement(19722..19735)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.79"
                     /tool="antismash"
     misc_feature    19734..19751
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 20.11"
                     /tool="antismash"
     gene            complement(19786..21111)
                     /locus_tag="JJ691_RS34745"
                     /old_locus_tag="JJ691_69530"
     CDS             complement(19786..21111)
                     /EC_number="1.6.5.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020631502.1"
                     /locus_tag="JJ691_RS34745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69530"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_211763791.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-46, bitscore:
                     158.5, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAAVKSEPARILIVGGGYVGMYTALGLQKKLRSREASVTVVDPQP
                     HMTYQPFLPEAAAGSIEPRHVVVPLRRTLRKCHVLTGRVTKISDADKVATVEMTDGHVE
                     EIPYDVLVVALGSVARTLPIPGLADRGIAFKTIGEAIYLRNHVLSRLDLAATTDDPEIR
                     KRLLTFTVIGGGYAGIEALAELEDMARYALRYYENLDPADMRWVLVEATGRIMPEVRES
                     LGVYTVKELEARGIEVYLDTRVKTMEDGHVVLDDGTEYDGDTIIWTAGVKANPVLAETD
                     LPLDQRGRVICTATMQVQGLDNVWSAGDNAAVPDLSKTDVDPAATCSPSAQHAVRQANQ
                     LAKNVVSVLRGRKPKPYVHKYVGSVASLGLYKGVADVYGVKAKGFVAWGMHRAYHVSRM
                     PTFNRKVRVAFDWLGSWVLKREVVSLGQINDPRAEFDRVTKS"
     gene            complement(21288..21986)
                     /locus_tag="JJ691_RS52635"
                     /old_locus_tag="JJ691_69540"
     CDS             complement(21288..21986)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016700518.1"
                     /locus_tag="JJ691_RS52635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_69540"
                     /product="uracil-DNA glycosylase"
                     /protein_id="WP_249227203.1"
                     /transl_table=11
                     /translation="MDLQDLDNAVIGCRRCPRLVAWREAAATQSRARPEEYWAKPVPGF
                     GPADARIAVIGLAPAAHGSNRTGRMFTGDRSGDFLFEALHAVGLASQPQAVSRDDGMRL
                     IDTRMAAPVRCAPPENKPTPEERDNCRPWLATELELLRPTLRAVVVLGAFGWQALLPVL
                     SAAGWTVPKPRPVFGHGVEVVLPAADGGPPLTLLGCYHVSPHNTFTGRLTQEMVRDVFR
                     RARAVADDQE"
ORIGIN
        1 cacctcgaac tcgcgcagga tggcgatcgc ctcggccacc gtctcgttcg ggtgcacgtg
       61 caccagctcc ggcatggtgc cgtccttgcg gcgcagcacg ttgccgacgg tcgcgccggc
      121 gtggtccggg gacaggaagc cgtaggaggc catccaggtg tcgttgaaga ccttggacag
      181 gtagccgcgg ccgccgtcgg gcagcagcac cacgatcacg tcgtccgggc cgcagcggcg
      241 ggccagctcg atcgcggccg cggccgccat gccgcaggag ccgccgacca gcaggccctc
      301 ctcgcgggcc agccgccggg tcacgtcgaa cgagtcggcg tcggagatcg ggatgatctc
      361 gtcgcagatg tcgcggtcgt aggtggtcgg ccagaagtcc tcgccgacac cctcgaccag
      421 gtaggggcgg ccggtgccgc cggagtagac cgagccctcc gggtccgcgc cgacgatctt
      481 gacccgaccg ccggagatct ccttgaggta cttgccggtg cccgagatcg tgccgccggt
      541 gcccacgccg gccacgaagt gcgtgatctt gccctcggtc tgcgtccaca gctccgggcc
      601 ggtggagtgg tagtggctct ccgggttgtt cacgttggcg tactggttgg gcttccaggc
      661 gcccgggatc tcgcggacca ggcggtcgga gacgttgtag taggactccg ggtgctccgg
      721 ggccaccgcg gtcgggcaca ccacgacctc ggcgccgtag gccttgagca cgtttcgctt
      781 gtcctcgctg accttgtccg ggcagacgaa gacgcacttg tagcccttgc gctgggcgac
      841 cagggccaag ccgacgcccg tgttgcccga ggtgggctcc acgatcgtgc cgcccggctt
      901 gagctcgccc gacttctcgg ccgcctccac catgcgcagc gcgatgcggt ccttcacgct
      961 gccgccgggg ttgaagtact ccaccttggc cagcaccagc ggcgccagac cgtcgacaag
     1021 tgcgttcaac cgcaccagcg gggtgttgcc gacaaggtcg actacgtgat cgacgtactc
     1081 caccggaggc cctttcgtct tgtgaactgg ccgcagccta acgcgttgcg gggaatcatc
     1141 ggtgttgcgt ggcgttgatc ccaatggacc atcgaccatc gaaccggtgg gagaatggat
     1201 ggggtgaggt cggacatggg tgtgatgcgt ggacttcggt tcgcggcgat cgccgccggc
     1261 acgctcggcg gtctctacgg cgcggcgtac gggctgctca ccaaccaggc gcggcgcgcg
     1321 gagcgaatca tcggtccccc agtcgccccg ccgttcctgg ccgacggcgt gtacctcccc
     1381 gacggctccg gccccgtgcc gccggccgag gaggacagcg ccctgcggtt cgcgatgttc
     1441 ggcgactcca tggccgctgg cctcggcgtg gacggtcccg accagctgcc cgccgtcgtg
     1501 ctggcccggg gcctggccga ggaggccggc cgcccggttc gcctggacac ctacgccgtg
     1561 gtgggcgccg ccaccaagga cctgccggcc caggtcgagc aggccctgct ggctcccccg
     1621 cacgtcgccg tgatcatcat cggctccaac gacgtcacca ccctgaccac cgtgcccgac
     1681 gccgtcgccg gcctcgaacg ggtgatccgc gcgctgcagg acgccggctg tggcgtggtc
     1741 gtcggcacct gccccgatct gggcgtgatc cgccccatcg cgcagcccct caagtccatc
     1801 gcccgggcct ggagcctctt gttggcccag gcccagcgca aggccgtcgc ccgcatcggg
     1861 gccatccccg tcgccctggc cgacctgctc gcgcccgagt tcctggcccg tccccgggag
     1921 ttcttcagct ccgaccagtt ccaccccagc gccgtcggct acgacgccgc ctgctcggtg
     1981 ctgctgccgg ccctgtgcac cgtggccggc gtgtggaccg gcgggcccct gcccaagctc
     2041 ccgcaccgct cggtgctggc cgagtcccgc cgccccaccg cgaggttcat cgcccgcgtc
     2101 aacttccgcc tcggccgccc cgcacgcgaa ctggccccgt agtcgcccga ggagagcttg
     2161 gccacaggca cggggtgggt ccggtcgcta gactccgctg gttaccaatg agtagcgaac
     2221 cgaaggagtt tcgcgatgcc cgaggccgtg atcgtctccg cagcccgctc gccgatcggc
     2281 cgggccggca agggatcgct ggtgtccatt cggccggacg acctggccgc gcagatggtg
     2341 cgggccgcgc tggacaaggt gccggccctg gacccgaccc agatcgacga cctgatcatg
     2401 gggtgtggcc tgcccggcgg cgagcagggg tacaacatcg gccgggtggt gtcggtgctg
     2461 ctgggcttcg accacctgcc cggctgcacg gtgacccgct actgcgcctc cagcctgcag
     2521 tccacccgga tggccttcca cgcgatcaag gccggcgagg gtgacgtgtt catctcggcc
     2581 ggtgtggaaa cggtctcccg gttcgccaag ggcagctcgg acggcctgcc ggacaccaag
     2641 aacccgctgt tcgccgacgc cgaggcgcgg accgtcgcga cggcggagca cagcggcggc
     2701 gaatggcacg acccgcgtgg cgacgagctc gtgccggacg tctacatcgc gatgggccag
     2761 accgcggaga acctggcgct ggccaaggac gtctcccgcg aggagatgga cgagttcggc
     2821 gtccgctccc agaacctggc cgagaaggcc atcgcggacg gcttctggca gcgtgagatc
     2881 accccggtga ccctgcccga cggcaccgtg gtctcggccg acgacggccc gcggccgggc
     2941 atcacgctgg agaagaccgc cactctcaag ccggtgttcc gcccggacgg ccgggtcacc
     3001 gccggcaact gctgcccgct caacgacggc gcggcggcac tggtgatcat gagtgacacc
     3061 aaggccaagg agctcggcct caccccgctg gcccggatcg tgtccaccgg cgtctccggc
     3121 ctgtcgccgg agatcatggg cctgggcccg gtcgaggcgt ccaagcgggc gctggccaag
     3181 gcgggcatgt ccatctcgga catcgacctg gtcgagatca acgaggcctt cgccgcccag
     3241 gtaatcccgt cctaccagga tttgggcatc ccgctggaca agctgaacgt caacggcggc
     3301 gcgatcgccg tcggccaccc gttcggcatg accggcgccc gcatcgccac cacgctgatg
     3361 aactccttgc agttccacga caagcagttc ggcctggaga cgatgtgcgt cggcggcggc
     3421 cagggcatgg cgatggtcct ggagcgcctg agctgaaccc ccagcggtga cgatcacagg
     3481 ccggcgtcga ccacgacgcc ggccttgttc gtcgtcaggt gcacgggatt ggccgtgtgc
     3541 aacaggtttc cgcagccgag gttgtcgaac gagccctgca accgctgggc caggaacgtg
     3601 aacaggttgc tggccgcgcc cggatccggc gacgggccgg tcttggtgaa gcgctcgtcc
     3661 agcttggtgc gctgcaggcc ggtggtcacc agggagcggc agtaggcctg cggcgtctcg
     3721 gttctcggat tgatcgccgg catgtccacg ccgacccggt acagattcgt cttggtcaca
     3781 ctggtcttcg tgccgtccag caccatcggg tcgttggtcg gcaccagcgc gatcggggcc
     3841 tgctgccggg cggcggcctg caactcgtcc agggccagcg aggtgacctg cttgccgctg
     3901 gccagatccg gcgcggtgaa gggcgtgcag cccagggccg ggtcgacgaa cgcgtccagc
     3961 agcacgttgt cgctgccgtt gttcagcttg gcgacgacct tggccttggt cttcgggtgc
     4021 accttggcct tgcccagctt cgtctcgttg gccggggtgt cctgcgcgat gcggccgtcc
     4081 ttggcctgga ggtaggtcgt ggtcacgttg tcgctctggt cctggtcgac cagcccgaag
     4141 tcccgggtgg tcatgcaggg cttgccgtcc ttgccggcgc ccagcgccgg gatggccagc
     4201 ttcttgccgg cgatggcctt gtctgccgcg gcgaagaacg gctgggcgtt gcagtaggcg
     4261 tactgcccga acacggagtt gttgtcgccg ttcacgcagg tgccggtgtc gccgcgcagc
     4321 gtgaggttgg tgccgttgaa gccgaaccag atgccgacga cggcgccgct cggcagcggc
     4381 ggcggggtcg gcgcgatctc cggccggctg cccttgtcga tcaccagcgg gtcgtacacc
     4441 gacagcttgc cggtggccgg gtccaggatc gtcgcctgca cgaacgccga ctggtcggca
     4501 ttggtctcgg tgcagtggcc cttggccgcg ctgatcaggt acggcgtggc caagcccttc
     4561 gcggacaacg ggttggccgg cacctgcagc acacagtccg ggttggcgat gtcggcctgg
     4621 ttcgcggcca gctgcggatc cccttgcacg gcaacggagg ccaccacggc gacggccgcg
     4681 gcgagcaccg ccagcgccgg cgcacccagc gcgacgcggc tgcgcacgga gagcttcttg
     4741 agctggggca gcacgaacgt cggccggatc gtcttccagc gcatcggtct tcctgtcacg
     4801 ggtaactcct catcgagagc ccactccacc ggtccgcact acgcacccgg tccggttggg
     4861 gttcagcaga aggagaaatc gacccgttaa cagcgcgagg ccgcgccggt gcctggaccg
     4921 cagccggatt tcacccgccg ccacccaacg caaccaccca cccagccgat gcggcgggtg
     4981 aaatccggcc agggaaggca ccggtcacga gcggcctcgc cccgcgcgga acgcgcggca
     5041 tgaaagagcg ccgacatcct cacggatgcc ggcgctcctg gcaagctgtg ttgactaatt
     5101 gcgttgcaac tgggccagca ggttcaggat ctccacgtac agccagacca gcgtgaccat
     5161 caggccgaag gcgatgtacc aggcgaacct ggccggggcg ccggcgcgga tggcccggtc
     5221 ggcctggtcg aagtccagca gcaggttgaa cgcggcgatg ccgatgaaca gcaggctgac
     5281 gatgatcgcc agcgggccgt tgccgcgcac gcccagatcg acgtggaaca gcgacagcag
     5341 caggttgaac acgaccagcg cgaacgcgcc catggtcgcg ccgatgatcc acttggtcag
     5401 ccgcggcgtg accttgaccg cgccggtccg gtagagcacc agcatggtgg cgaacaccac
     5461 cagggtgccg acgatggcct gcacggccac gcccggcacc aggtagtcga tgaccttggt
     5521 gatcgtgccg aggaacacac cctcgacggc cgcgtaggtc aggaccagcg cggggttggt
     5581 ggattgccgg aaggtgatga cgaacgccag caccatgccg acgaggccgg cggcgagcgc
     5641 gaagagcggg tgcagcccga ggtaggcggt caccccgccc accacgatgg tcgtgcccag
     5701 cgcggtcgcg gtcttggtga ccacgtcgtc gatcgtcatc ggccggtcgg cggcggtggg
     5761 cggcgcggcc gggtagccgt acccggtcgg ttgctgcccc tggtacccga agttcgcgta
     5821 gccgccctgg ccctgaccct tgccggacag cgcgcggaac gccgggttgc tcgatgtgcg
     5881 cacctggtcc tcctggaacg tgtggcgcct acagcccgta caacggtaac cgtgatcgat
     5941 cggttccccg tggggcaaag gtcattttac caacgtggac gaacgggcac tgatccgttc
     6001 ggcgtagcga tcaactactt cacactgtat tgacacgcag agtgtcctcg gacatcctcc
     6061 cgctggcggc ttgcccgccg tccgcgcgcc cgccaggctc gcagggcggc ctaccacggc
     6121 cttctcgttc cgtcggggga acgagccccg gaccgccgcc acgaagacgt ccgacctaac
     6181 acgaagggca ccgcgccgcg gggaagcggc acggcgccca tgagggagcg caggaccgtt
     6241 atgggactga gcaaactggt cgctggggtg accgggatca cgatgctggt ggccggcctc
     6301 ggcgtgttgg ccgcgccgac cgcgagcgcc gccgtgcaga cgggctccgg cctcaacgtg
     6361 ccgaagcagc cgtacaaggg ctcgccggcc aacgacccga acgactggct cggccagtac
     6421 atcgtgggcg gcaaggcggc ctactgcgtg cggttcgccc tagccgcgcc cgactccggc
     6481 gcgaagtacg acccggacgg cgacctgacc gacaagtggg gcggcgcgat cgaccccacg
     6541 aagctcgccg aggtctccta catcctgctg cgctacggcg acaccaccgg cctggccaag
     6601 gatgtgggcg acgctcaggc cgcggcggtg gcgcacatcc tgcacagcat cacctccggc
     6661 ggccggccgg ccaacccgaa cgacggcccg aacgaggtcg cctatgacac ggccctgcac
     6721 ctgaaggaac tgccgcaggc cgcccaggac gacgtggcca agatccagac ggacgcggcg
     6781 gccaactacg gcccgtggaa ggcgaccgtg accccgccga ccgcggccca ggtcatcggc
     6841 accgccgaca agtggacgat caacgtcgtg cgggacggcg gcgacggcgc ggcgatcaag
     6901 ggcgtgccgg tgaagctgac cgtcaccgac ggcaaggtcg actccgacac cgtgaccacg
     6961 ccggccgacg gcagtccgct ggtggtcaac gtcacgccga ccggtcccaa cccgacagtg
     7021 aagatcgacc tcgacgcgcc gctggccaag ccgacggtgc agaagccgga gaaccagccg
     7081 gccaacttcc agtggacggt cttcaccggc ggccagggcg cgatcaccag caccggcaag
     7141 acgaccgcca ccaccgcgcc gggttcggtc aaggtgacca aggtggacag caagaccggg
     7201 gccggcatcg cgaacgtgca gctgcgggtc accgccgcgg acaagacggc ggccgcggtg
     7261 aagcaggacg gcagcccgct caacggcacc gacggcaagc cgctggtggt caccaccggc
     7321 gccgacggaa cggccactgt ggacggtctg aagacgccgc aggacatctg catcatcgag
     7381 gtcgcggccc cggccggcta cgaccagaat ttcgacgcct cgtcgccgcc gaacgcctgc
     7441 ggctccatcc aggccggcca gacgctggcg ctcaaggtgg ccaacacgcc caacacgccg
     7501 accgtgccgg tcaagatccc ggccggtggc tcgccgatgg tcgccgacgc ggccaccgtc
     7561 accacgctcg acccggccgc gctggccgcg gtcggtggcc tggcggtgat cggcctcggc
     7621 ggtgtcggcc tgctgctgcg ccggcggcgg cacgcctcgc gtggctaagc accgggctcc
     7681 gaagacccgc tggccggttt cggccggcgg gtttccggtt gccggccggt ccaggtaccg
     7741 gaatccgacc gccgccgccg gcacggccgt cagcggcgcg gtcggactga ccatgatcgt
     7801 gatggcggcc ggggcgaccc tgttgggcca gccccagtcg gtgccgggct cgccgctgcc
     7861 ggtcggccac agccagacgg tcgacccgca ggccggcccg gccccggtcg ccgcgccggc
     7921 gaccaccacg tcgtcggccg cggccccgcc accggcggcg acccagcaga ctccccagcc
     7981 gccggccccg aacaccatcc tgctgcccaa gggcggccgg tcgtcgctgg tgcgcagcgg
     8041 tgtcgccggc gacggcacgc tgcagatccc caacggcgtg accaaggccg cgctgtgggg
     8101 tgcggccctg gacgggccag ccggggcgac gctgatcgcc gggcacatca actgggacgg
     8161 cgtcgccggg ccgttcgccg agctctgggg cgcgcaggcc gggcaggacg tgaccgtcgt
     8221 cgacggcgac ggcaagcagc tgaagttcgt cgtcgaccag gttctgaccg tggacaagga
     8281 caatctgccc cagcacgccg acgaactgtt cggccagacc ggcgcgcacc ggttggtgct
     8341 ggtcacctgc ggtggcaagt gggtcggcgg ggcgctgggc tacgaccaga accgcgtggt
     8401 gatcgcccac cccgtgtcct gacgacaacc cgatcggggc ctgcgtcgtc tcaaccggca
     8461 tggggctcag gcagaggtgg ggttggctga cgaccgcggt ggcgttggcg ctggccgtgg
     8521 tggtcgtgat cgtgatgggg cagggaacgg gatcgggcgg aacaacaccg gccggagcca
     8581 ccacaaccac caatcccggg ccgatcacgc cggccggcca ggccaccccg gccgccggcc
     8641 cgaccccgac gctgcccgcg cccaccgggg cccagccggc gtggatgcac aagctcaagc
     8701 ccggcgagaa gccgccgcag ttcatcctgt tctccttcga cggcggcgcg tccaaggacc
     8761 actggtcacg ggtgctgccg atcgccgagc ggaccggggc caaggtgacg gcgatgctgt
     8821 ccgggctgta cctgatcccg gacagcgaga agaactccta caccggcccg gggcacccga
     8881 acggggccag cgagatcggc ttcggtggct cggacgcgga catcaagctg cgtgtggact
     8941 acctgaaccg ggcgctggac gacggcatgg agttcggcac gcactacaac gggcacttct
     9001 gccagggcgc ggagcccagc gtcggcttct ggtcgacggc cggctggaac tccgagctgg
     9061 accagttctt ctcgtacctc aaggagatcg acggcaaggg cctgcggatc acgcccgaca
     9121 tgatcaaggg cggccgcacg ccgtgcctgg agggcaactg ggaccaactg ttcccgtcga
     9181 tgaagtcgca cggtttcgtc tatgacacca gccatgtctc gttcggcgtg acctggccga
     9241 cggtggaccg cgggctgtgg gagttcccgc tgccggaggt gcgggtgccg gcgctggaca
     9301 agaacgtggt gatgatggac ttcaacttct ggtacctgtt ggacggggcc aaggagggcg
     9361 acgacgcgcg cgggcccgag ttcacgccga tcgtgctgga cacctaccgg tcggtgtacc
     9421 agaccgtgtt caacggcaac cgggctccgc tggtgatcgc caaccacttc aacgactggg
     9481 ccggcggcgc gttctccggc gcggtggagc agttcatgag cgagacctgc ggcaagccgg
     9541 agacggtgtg cgcctcctac agccaggtga tccagtggat gcagctgcag gacccggcca
     9601 ccctggacgc gctgcgctcg ctgccggcgg cccacaacta ggcggtcaat ccgcggtcaa
     9661 tccgtcgaaa gaagtgccgg gacggatcgg aaggtgtcta gccgggagcc gcagaaaggg
     9721 cttactgtgg tgttccgccg cggccttgcc cacacagatg tcgtccaagg agtgagcgat
     9781 gtccgcaccg aagaccgtca agcgcgccga gaagtccgtc cgcaagcccg cccgtcgttc
     9841 ctgggtgaag cccgacttca atgagtacga cacgccgatg gaggtcaccg cgtactccgc
     9901 gcgggtctga cctgtcaagg gttcactgtt tggaagggac cattcctcac gttcaacgtc
     9961 aggaatggtc ctttcaccca cgcccatcga ggagtcgaac atgctggcgg ccgaggactt
    10021 catcgccgag ctgcgggcgc tggccccgcg ctactggcac gaccacccgt tccacctgcg
    10081 cctgcacgcc ggcgacctca gccgcgagga gctccagcgg tgggcggcca accgctggta
    10141 ctaccagcgc agcctgcctc agaaggacgc ggccatcctg gccaactgcc cgttgtcgca
    10201 ggtccggcgg tactggatgg agcggatcgt ctatcacgac ggcagccgtg acggcgaggg
    10261 tggcgcggag aactggctgc gcatggccga ggccgtcggc ctggaccggg ccgaggtgct
    10321 ggacgagcgg catgtgctgc cgggcgtgcg gttcgccgtc gacgcctacg tgaacttcgc
    10381 ccgcagcaag ccatgggtgg agtccatcgc ctctgggctg accgagatgt tctcccccgg
    10441 cctgatgaag cggcggctgg ccgacatgcg ggagcagtac ccgtggatcg gcgaggacgg
    10501 cttcgcctac ttcgtgtccc ggctgaccgt gatcgccggc gagggaaagt ccactttgga
    10561 catcgtggtg gagcacgcgc ggacccgtga gcagcagcag gcctgtgtgg ccgcgctggc
    10621 gttcaaatgc gatgtgctgc aggcgatcct ggatgccgtg gactatcact catgacttcg
    10681 ctggactccg tgcctcgggt gcgccggggc gtgcggtgca cgtacgacaa gacccgggac
    10741 agcgatgtcg tgctgttccc ggagggtgtg ctgctgttga acgagaccgc cgccgccgtg
    10801 gtgttccgct gcgacggctc ggccagcgtc ggcgacatcg cgctggccct ggccgacgag
    10861 ttcgacggcg tgcagcccga tgacgtgatc gagctggtgg atcggctcgt ggcccgacgg
    10921 gtggtggacg ttgactgagg cgccgctggg actgctggcc gagctgacgc accgctgccc
    10981 gctgcactgc ccgtactgct ccaatccggt cgagctggtg cagcgcgccg acgagctgga
    11041 cacctcgacg tggcaacggg ttttcgacga gggtcgggaa ctcggcgtgt tgcaggtgca
    11101 cctgtccggc ggtgagccgc tggcccgtcc cgacctgccg aagctgttgg cccacgccag
    11161 cggcctgggc tgctacacca atctcgtcac cagcggtctg ggcctgaccg ccgagcggct
    11221 ggccgaactg gtctccctcg gccttgacca cgtccagctg tccgtacagg acgcggatcc
    11281 ccgcaacgcc aacctgatcg ccggcgtcaa gggctacgac cgcaagctgg ccgccgccgt
    11341 gctgatcaag gacgcggagc tgccgctgac cgtgaacgcc gtgctgcaca aggcgaatct
    11401 cgaccacatc ggcggcatca tcgagctggc cgagcagatg ggcgcggacc gcctcgaact
    11461 ggccaacacc cagtactacg gctgggccct gcgcaaccgg gccgccctgc tgcccacccg
    11521 ggaacagctc gccgccgccg gacccgttgt gcaggaagcg aaacagcggc tggccgggcg
    11581 gatggagatc gtctacgtgg tcgccgacta ccacgaggcc aaccccaagc cgtgcatgta
    11641 cggctggggc gcccggcagc tcaccgtcgc ccccaacggc gacgtgctgc cctgcccggc
    11701 cgccagcgtg atcacctcgc tgcccgtgca gaacgtcctg cgctcctcgc tggccgagat
    11761 ctggtacggc tccgagacct tcaacgccta ccgtggcacc gagtggatgc gggagccgtg
    11821 ccggagctgt ccgcgcaagg agatcgactt cggcggctgc cggtgccagg ccttccagct
    11881 caccggcgac gccgccgcga ccgaccccgt gtgcacgctg tcgccggatc atggcctggt
    11941 gcaagacatt ctggctgccg agatcaccat cgaacggccg gccttcgcca tgcggcggtc
    12001 ggtgtgaggg tcgtcgtgct cggcaccgcc gccggcggcg gcttccccca gtggaactgc
    12061 gcctgttccc cttgtgcctt ggcccgcaag ggtttgctgc cgtcccgtag tcaggactgc
    12121 cttgccgtca gcggaaacgg ctccgattgg tggctgctca acgcctcccc cgacatccgg
    12181 gtgcagctgg tgggttcccc ggagttcacc cctggtcccg gccggcgcga caccccgcta
    12241 cgcggtgtcc tgctcacctc ggcggagctc gaccactccc tcggcgtctt ctccctccgt
    12301 gagggcggcg gccagaccct ctacgccccg gccaacgccc tctcggccct gcggtcgaat
    12361 ctcggtctgg ggcccgtgct cgacaactac gccggctggt cgtggcacga gaccgtgccg
    12421 gagcagccct tcgagctgac cggcgagctc gtcgccaccg cccacgccgt cggcgtcaaa
    12481 cgccccaagt acgccggcga gcagcctggc ccctgggttg tcgcctaccg catccacgac
    12541 ccggtcaccg gcggcaccct gctctacgcc ccctgtctgg cctcgtggtc cgccgatttc
    12601 gaggccctgc tggccggcgt cgactgcctc ctgctcgacg gcaccttctg ctccaccgac
    12661 gagatgggcg tgcgcaccgg ccataccaag ggccagtcgg ccatgggcca cctgcccgtc
    12721 ttcggcgacg gcgggagcct gcccgaactg cggcgattcc cggccatgcg ccggatctac
    12781 acccatctca acaacaccaa ccccctgctc gacccggcct ccccggagtc ggccgagatc
    12841 gccgcggccg gcgtcgaggt cgtcccggac ggcaccgtgg tcacgctctg acgatcggct
    12901 caaagacccg ttgccacggc ggcaatcctc cctccgtgac ccgtgacttg tggttagctc
    12961 tcacgcgtgc gtgtagtcat cgcggaagac ctgctgctgc ttcgggacgg catgatccgg
    13021 ttgttgcagg ctcacggctt cgaggtcgtc gccgccgtcg agtccgggcc ggagctgctg
    13081 gccgcgctca ccgagcacaa gccggacgtg gcggtggtcg acgtgcggct gccgccgacc
    13141 ttcaccgacg agggcgtgcg cgcggccatc caggcccggc gcgagatccc cgggctgccg
    13201 gtgctggtgc tgtcgcagta cgtcgagcag ctctacgccc gggaactgct gtccgaccgc
    13261 agcggcggcg tcggctacct gctcaaggac cgcatctccg acgtgaagca gttcgtggac
    13321 gccgtgcgcc gggtggctga cggcggcacc gccatggacc ccgaggtggt cgcccagctg
    13381 ctgtccagcc gtgagcgcga cgccccgctg ggcaccctca caccgcggga gaaggaggtg
    13441 ctcggcctga tggccgaggg ccgctccaac gccgccatcg cggcccgcat gttcgtcacc
    13501 gagaaggccg tgggcaagca caccaacaac atcttcacca agctgaacct gcaccagcac
    13561 gaggacgaca accgccgggt gctggcggtg ctggcttatc tgaacgggtg atcgttgcaa
    13621 gccaggtctc acccaccccc gtgatccacc cattcgggtg gcgtggcagg tagggtcggg
    13681 cccggtgtgc cgggaagtct ggtcggcgag tttcgtggac cccggcgaaa ggtgccagcg
    13741 atgcagagcg tggaaacggt gctcctgctg gtggtgctgg cgacggtggt cgcgaccttc
    13801 gcccgccggc tgagcattcc cgcgccctcg ctgctggtgg tggcgggcgt ggtggtgggc
    13861 ctgttcccgg gggtgccgga ggtccgggcg acgccggagc tggtgagcct ggtggtgctg
    13921 ccgccgctga tctacgcggc gggcgaggag atgccctggc gtgacctgcg cgcggtgtgg
    13981 cggccggtga cagtgctggc ggtcggcctg gtgctggcct cggcggcggc ggtcgggctg
    14041 gtggcggcgc tggtggcccc actgccggcg agcatggcgt tcgtgctggg ggcggtgctg
    14101 gcgagcacgg acccggtggc ggtgagcgcg ctgggccgcc gactgtcgct gccgccccgg
    14161 atccaggtgc tggtgcaggc ggagagcctg ttcaacgacg cgacgagcct ggtgctgttc
    14221 cggctggcgg tgacggcggc gctggccggc ggcgcggtgt cggcgggatc ggtgggcggc
    14281 gagttcctgc tgctggccgg cggcggcctg ggcgtcggcc tggtggtggc cggcggcatc
    14341 tggctgatcc gccggcgcac ggtggatccg gtgctggaga cggtgatcgc gctggtcagc
    14401 ccgtactcgg cctacgtgct ggccgagaca ctgggcggct cgggcgtgac ggcggtggtg
    14461 gtgtgcgccg tggtgctcgg cgcgcagact ccgaagatca ccaccgccca catccggctc
    14521 caggtggacg cggtctacgg cacggtgatc ttcattctgg agagcgcggt gttcgggctg
    14581 atcggtctcc agctgccgta cctggtacgc gggctggccg gctccgaccc gggctggccg
    14641 tggcaggcgc tggtgatcac ggccgcgctg atcgcaatcc ggttcctgtg ggtgttcccg
    14701 ctgggctgga tcatgcagct gcggcgcgga aaccgccgcc tcaactggcg aacgtccaca
    14761 gtggtctcct gggccggcgc ccggggtgtg gtgccgctgg ccgcggtgct gtccatcccg
    14821 ctgctcaccg acaacggcga accggtgccg cagcgcgacc tggtgctggc gctggccacc
    14881 acggtcatcg tgatcacgtt ggtggcccag ggtttcacgc tcgcgccgct ggtcagacgg
    14941 gctggcatcg cccgtacgcc ggccgaggcc cgccgcgagc aggacctggc caacgtgcgg
    15001 ctggccgagg ccgggctggc ccacctggag cagctctatg acctggaggc cgcgccgcac
    15061 gcggtcctcg accggctcag acagggcctg ctggcccgga tcgaccacgg cgacccccag
    15121 gaggaaccgc ccggctcctc ggtcgccgcc acctacaagc aactgcgccg tgaactgctg
    15181 gccgtggaaa tggccgagct gaccaggctt ttcgacgacg gcgaaatcga cgacagcacc
    15241 cgccgccgcc tgcagcgcac cctcgacctg gaggacgccc gcctgggcga cgactcctag
    15301 gctccgatgt aggtcagcag gaactccgcg acgcctagga cggccgcggt cgactccggc
    15361 acgtccggca cgaacaggtg ccagaagtgc atcaggtccg gccagatctc caggttggcc
    15421 cggccgcccg cggcgagcac cgccgcgacc agcgagcggg cgtcgtccac cagcacctcg
    15481 cgctcggcgg cgtgcaccat cagcggggcc aggccggaca ggtcggcgaa cagcggcgag
    15541 gccagcggct cgcgcggatt ggcctcgccc aggtagtcgg ccgccgccgc aagcgcttgc
    15601 gcccggctgt agatcgggtc gtcgtcggcg aacttgtcgt acgacccgcc gctcgcggtc
    15661 aggtcgaaca gcgggctcag gcaggcgccc gcggccggct gcggcaagcc caggtcgcgg
    15721 gcggccagca tggccgccac caccaggccg ccgccggcgg tgtcgccgag cagcaccacc
    15781 cggcccggcg agtagccccc ctcgtccagc agccaccggt aggccagcac gacgtcctcc
    15841 accgccgacg ggaaccggtg ctccggggcc agccggtagt ccggcagcag caccggcatg
    15901 cccatgaccg ccgcgaactg cgaggcgaag ccgctgaacg ccgtcgccga accggcccgg
    15961 tagccgccac cgtgcaggta gagcagcacc cggtccatcg cgccgccctg cggccggacc
    16021 cacaccgccg ggcagccgcc cgcgtcggtc tcgccggtca gcacgccgtc ggccagcggg
    16081 atcgagccca gcgccaggtc catcgactcg cgtgcctgcc gcacgccgtc cgcgccagcc
    16141 gccggctcgg gccgtggact ggcccggatg gccgtgagca gcgcctcgaa ctcgggactg
    16201 ggcatcgcgt catctctacg ggaacaggga gacgaaccta catcagacag gtcccaactc
    16261 cgtgacgccc gtcaccgccc cgagcgaaac ctcgcaccgc acggcgtgcc gccttgacgt
    16321 ttcacgtgaa gcagtgctca tgcggcgcaa cctcacactt gcgactaccg aaaaaactcc
    16381 ccataatcgg tagtcgacca gggaggtaga catgtcggtg gccgccgaga aggagcagac
    16441 cgagcggctg ctggccaacg tcgaggcgat cgaggaggtc gccggcacgc tgcccagcgg
    16501 cgctcccggg cgcagcaagc tgtacgacgt ggccgacaac ctgctggaca gcgccatgcc
    16561 gatccggccg gtggtggccg ccgacctgct ggagctgacc gagaagacgg tgcgggcctg
    16621 ggccagcgag ggtgtgctgc tggtcagcga gcaggagccg accatgcgac tggagccacg
    16681 ccgggtgcac gaggtgatgc acctggtccg ggagatccgc cgcatcggcc gcacccgcgg
    16741 gctgctcgac gaggtgcacc gccggctgag cgaccaggcg ctgctggagc gcgtggacct
    16801 ggccgagagc ctggaccagg tggtccgggg cgagggaacg gtcgtgcgct cggggacgac
    16861 gatccctgag tgatcgaagt agtcgagacc cgcgtcgcct cggcgcaggc cgcgctgctg
    16921 cgcggaccgg cccgcaaggc ctacgagtcc ttcctggacg agctcgccca ccgcggctgc
    16981 gccgccctgg gctaccgcgt caccggcccc gcgccgctgc ccaggctgtg cgtgcgccat
    17041 ctccgtgaca acgaccgggt ggtggtggcc ttcgagggag ccggccgggc ctggatcgtg
    17101 ctcgtcggcc cgcacgagca gaccgacccc ggccgcaacg tctacgacgc cctgtacgag
    17161 ctggccggta cctggccgac cgacaacacc cgccgcacca agcccagctg ctgcgacccg
    17221 aacaccggca ccccgccctc ggccgaggcc gaggtgatcg acgacctggt ccgccgggcc
    17281 cgctcactgg cccgtggcag ccgtcgaatc tggtgaatta attcgggcca attccgagca
    17341 tgccgaaacg cgacccaggg cagttctccc cgagtcgcgt cccgtttccc ggaagtgcag
    17401 tgctcgccgt acgtcagtac gcggccgcca tgttcccggt gccggcgact ccacgctccc
    17461 cgacatagcg cgcgtcaccg aagcccagga tcaggaaacc gatgacgttg aacagccaga
    17521 ggccgacaac gccgaacacc ttgctcttgc cgaagttgcg cgccacgtcc atcgagacga
    17581 tgaggtgcac gatgatgttg acgatcggga tcaggtacag caccacccac cagcccggcc
    17641 ggcccgcgac cttcatcaac aggtagatgt tgtacagcgg gatgatcgcg ccccagccgg
    17701 gcaggcccgc cttcgtgaac acgcgccaca ggccgacgat ggcgatgaca ccgacaataa
    17761 gaccgccgac agaggtactg gtggagtcca tgacccatca ctttctacac acaggaaaca
    17821 acaaaccgaa cgccgacggg cgccatcgcg acaccggttc gaaacaattt cgaaaccccg
    17881 acacttaatc ggccaccgat cgacgggagg ggacattagc cgacaccccc gtccatttcg
    17941 ccccgtttct acccagaggt gcgatcaggc agcaactcgt gtccgttcac gcccaccggg
    18001 tatccctgtt tcaccgtttg tttcagtgcc gcgacggacg gcgacgggag caccgcgcaa
    18061 ccggcagatg tcgagactca agtctcaggg cagcgatggg gcagacacac tcagcgttgg
    18121 cccgatgtca ccagccgcgc cgggcacatc ccctgaccgg attaaccaca ggtcaggggg
    18181 tggcgggtcc tggtgacgga gagtgccccc gatcggactc gaaccgacac tctgaccctt
    18241 ttaaggggcc tgcctctgcc tattgggcta cgggggcgtg gggagcctaa gcggtccggc
    18301 ggcccaaggt caggtacttg cagccaattg agaccctgtt cgcccacccg gcggatcgtt
    18361 cgggcatccg gtggaggtac acgggcaccg gtcagcgccc ccgatcggcg gcgagcagct
    18421 cggcgaaacg cacggccacc cactcgtgca cggcgtcgga cacgtcggtg ctgccggcgc
    18481 ggtgctcgaa ccagcgccag tcgcagttga cgttgacctc caggaagacg tgctcgccgt
    18541 cgacgacgag cagatcgaag gcggcgacct ggagccgcca gtgccgggcc agggccagca
    18601 gccggtcggc cagggcgcac ggcacgtcgg tgggcttgac cgacacgttg tcggggtcga
    18661 cccacagctg ggccgggtcg tatttgtcga cctggaagcc gatcaggcgc tccccgacga
    18721 cgaagatccg cagctcggtg tcggcggcca ggtactgctg cacgatcacc ggcgcgacct
    18781 cgggcacgtc gccggcgcgg gcggtgtcca gcgggcgtgg gaacaggccg tgctgcacgc
    18841 cgggccgagg ctcgacgagg tgccgcccgg acgtcttgac gatgcactga ccgccgccgg
    18901 gtctgctccg tccgggttgg gtcgtcacgg ccgtcctggg cgtcctcagc ccgaaagcgg
    18961 cggcatcggc gagctgggtg agccggttga ggtgcccggt ggcccgagcc gggttcacat
    19021 gggcccactc ggtccgctcg gtgagccagc cggccacggt ggaccactgg tccagcgcgt
    19081 aggcgccgct gatggtccgc gggtccaccg gcatggcggc cagctcgaag tggcgccgcc
    19141 agaccagcag gggccgcagc agccagcggt tgagttccag cagcggggtg tcggtgtaga
    19201 tggtcaacgc caggtcgagg cagcggtcca cgtcgatgcg ggccatccgg atgccccgct
    19261 cggccagggc gatggacagc tcgttcatct ccatgtcggc cgaccgggcc agcaccagca
    19321 cgcagggcgc gggctcgccg ctgtcctcga ccatgtcgag gcggtggatc tgctcctgga
    19381 agtcgaaaca gccgctgggc gcgcggaaca cgtagtcctg gccctgcagc aacagaggag
    19441 tcgggcgggc ggggagcatc ggctggggcg ggccgtccga ctgggcccgc ccagcgccga
    19501 tcatgctcag tcgtccttct tgctgcggga gatccgctcc gcgcgtgcgt actcggcagc
    19561 gaactccgcg agcgcctggt cctcgatctc gccgctgcgc agttgcgcgg ccaggtcctc
    19621 catcgacatc gcggtcacct ctttccccga aggcgcatca cacgttcagg cgatccgccc
    19681 cgggtagttt cgggacccgc ctaacgcaat gtcaagacga ctgacactga tcatagccca
    19741 ttcggcggat caagctcggc gtgtcgtgcg ccgatgggga aattctcagc tcttcgtgac
    19801 gcgatcgaac tcagcccgcg ggtcgttgat ctgaccgagg gacacgacct cgcgcttgag
    19861 cacccacgag ccgagccagt cgaaggccac ccgcaccttg cggttgaacg tgggcatccg
    19921 ggacacgtgg taggcgcggt gcatgcccca cgcgacgaag cccttggcct tgaccccgta
    19981 gacgtcggcc acacccttgt acaggcctag gctggccacc gagcccacgt acttgtgcac
    20041 gtacggcttc ggcttgcggc cccgcagcac cgacacgacg ttcttggcca gctggttggc
    20101 ctggcgcacc gcgtgctgcg ccgacgggct gcaggtggcg gccgggtcga cgtcggtctt
    20161 ggacaggtcc ggcacggccg cgttgtcgcc ggccgaccag acgttgtcca ggccctgcac
    20221 ctgcatggtg gccgtgcaga tcacccggcc gcgctggtcc agcggcaggt cggtctcggc
    20281 cagcaccggg ttggccttca cgcccgcggt ccagatgatc gtgtcgccgt cgtactcggt
    20341 gccgtcgtcg aggacgacgt ggccgtcctc catggtcttc acccgggtgt ccaggtagac
    20401 ctcgatgccc cgggcctcca gctccttgac cgtgtagacg cccaggctct cgcgcacctc
    20461 gggcatgatc cggccggtcg cctcgaccag cacccagcgc atgtcggccg ggtccaggtt
    20521 ctcgtagtag cgcagcgcgt agcgggccat gtcctccagc tcggccagcg cctcgatgcc
    20581 ggcgtagccg ccgccgatca cggtgaacgt gagcagccgc ttgcggatct cagggtcgtc
    20641 ggtggtggcg gccaggtcca gccgcgacag cacgtggttg cgcaggtaga tggcctcgcc
    20701 gatggtcttg aaggcgatgc cgcggtcggc caggccgggg atcggcagcg tgcgggcgac
    20761 cgagccgagg gcgacgacca gcacgtcgta ggggatctcc tcgacgtggc cgtcggtcat
    20821 ctcgaccgtc gcgaccttgt ccgcgtcact gatcttggtg acccggccgg tgagcacatg
    20881 gcacttgcgc agcgtccggc gcagcggcac caccacgtgg cgcggctcga tggagccggc
    20941 ggcggcctcg ggcaggaagg gctggtaggt catgtgcggc tgcggatcga caaccgtcac
    21001 cgacgcctcc cgggaccgca gtttcttctg cagccccaac gcggtgtaca tgccgacgta
    21061 gccaccgccg acgatcagga tcctcgcggg ttccgacttc actgccgcca tacgcgtaat
    21121 ggtcgcaccc gtcgccctgg gccgctgccc acaacgggcc cgatgtgacg gcgatccctc
    21181 gtgagcatga tcactgtctg ttgccgagct gccggacttg acgggttcat cccggttggc
    21241 cgaatcggtt caccgtccga tcgggtcaga atcggcgcac cctatcgtca ctcttggtca
    21301 tccgcgaccg ctcgggcccg gcgaaacacg tcccggacca tctcctgcgt cagccgaccg
    21361 gtgaaggtgt tgtgcgggct gacgtgatag cagcccaaca gggtgagcgg cgggccgccg
    21421 tcggccgccg gcagcacgac ctcgacgccg tgcccgaaca ccggccgcgg cttcggcacc
    21481 gtccagccgg ccgcgctcag caccggcagc agcgcctgcc agccgaacgc cccgagcacc
    21541 accaccgccc gcagcgtcgg ccgcagcaac tccaactcgg tcgccagcca cggccggcag
    21601 ttgtcccgct cctccggcgt cggcttgttc tccggcggtg cgcagcggac cggcgccgcc
    21661 atcctcgtgt cgatcaatcg catcccgtcg tcccgggaca cggcctgagg ctgcgaggcc
    21721 aagcccaccg cgtgcagcgc ctcgaacaga aagtcgccgc tgcggtcgcc ggtgaacatg
    21781 cgccccgtcc ggttcgagcc gtgcgccgcc ggcgcgaggc cgatcaccgc tatccgggcg
    21841 tcggccggac cgaaccccgg caccggcttg gcccagtact cctcgggccg ggcccggctc
    21901 tgcgtcgccg cagcttcgcg ccaggccacc agccgcgggc accgtcgaca tccgatgacc
    21961 gcgttgtcca gatcttgtag atccacggtg gttagggttt caccatg
//
