LOCUS       NZ_CP073318            23828 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6391802
            Orig. end                         :: 6415630
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23828
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="40"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..23828
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23828
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13828](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13828)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    1333..1346
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.92"
                     /tool="antismash"
     misc_feature    complement(2327..2345)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 21.6"
                     /tool="antismash"
     misc_feature    complement(3211..3226)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.27"
                     /tool="antismash"
     misc_feature    3588..3602
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 18.01"
                     /tool="antismash"
     tRNA            3604..3675
                     /anticodon=(pos:6395438..6395440,aa:Val,seq:tac)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="JJ691_RS28010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="JJ691_55950"
                     /product="tRNA-Val"
     gene            3604..3675
                     /locus_tag="JJ691_RS28010"
                     /old_locus_tag="JJ691_55950"
     gene            complement(3884..4342)
                     /locus_tag="JJ691_RS28015"
                     /old_locus_tag="JJ691_55960"
     CDS             complement(3884..4342)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1196: alkyl hydroperoxide reductase/ Thiol specific"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007032783.1"
                     /locus_tag="JJ691_RS28015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_55960"
                     /product="peroxiredoxin"
                     /protein_id="WP_211762607.1"
                     /transl_table=11
                     /translation="MALEVGTQAPDFTLKDANREDVTLSSFRGEKNVLLVFYPFAFSGI
                     CTGELCQVRDELAEYQNDEVQVIGVSVDTPFSLKAWAEKEGYSFPLLSDFWPHGATAQA
                     YDVFNDKAGMALRGTYLIDKQGVIRFAEANQPGEARDQDQWKRALKSL"
     gene            complement(4408..4839)
                     /locus_tag="JJ691_RS28020"
                     /old_locus_tag="JJ691_55970"
     CDS             complement(4408..4839)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003084504.1"
                     /locus_tag="JJ691_RS28020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_55970"
                     /product="DUF3052 domain-containing protein"
                     /protein_id="WP_211771767.1"
                     /transl_table=11
                     /translation="MVAAGDAGKVGVADRLGIEPDMVVQEIGWDEDVDDDVRAAIEERI
                     GSDLLDEESDEVVDVVLLWWRESDGDLVDTLMDVTGPLAEDGVIWVLTPKTGRPGYVEP
                     SDIAEAVPTAGLAQTLNASVGEDWAGIKLVSPKSAKTKR"
     misc_feature    4892..4910
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 19.28"
                     /tool="antismash"
     gene            5154..7931
                     /gene="aceE"
                     /locus_tag="JJ691_RS28025"
                     /old_locus_tag="JJ691_55980"
     CDS             5154..7931
                     /EC_number="1.2.4.1"
                     /GO_component="GO:0045250 - cytosolic pyruvate
                     dehydrogenase complex [Evidence IEA]"
                     /GO_function="GO:0004738 - pyruvate dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006086 - acetyl-CoA biosynthetic process
                     from pyruvate [Evidence IEA]"
                     /codon_start=1
                     /gene="aceE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1204: transketolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020644600.1"
                     /locus_tag="JJ691_RS28025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_55980"
                     /product="pyruvate dehydrogenase (acetyl-transferring),
                     homodimeric type"
                     /protein_id="WP_211762608.1"
                     /transl_table=11
                     /translation="MAPQSNGAGSASPPERVRVIRDGLAAHLPDIDPDETAEWLESFDG
                     VLKGAGQQRARYLMLRLLERARESRVGVPSLTSTDYVNTIPTEQEPWFPGDEETERRYR
                     AWIRWNAAMTVHRAQRPGVGVGGHISTYASSATLYEVGFNWFFRGKDHPGGGDQVYFQG
                     HASPGMYARAFLEGRLSAEHLDGFRQEYSHAGPGGGLPSYPHPRLMPDFWEFPTVSMGL
                     GPMNAIYQARFNRYLRDRGIKDTSQQHVWAFLGDGEMDEAESRGLIHVAANEGLDNLTF
                     VINCNLQRLDGPVRGNGKIIQELEAFFRGAGWNVIKVVWGREWDSLLHADRDGALINLM
                     NTTPDGDYQTYKANDGAYVREHFFGRDPRTKELVAPMSDQDIWNLKRGGHDYRKVYAAY
                     KAATEHNGQPTVILAKTIKGYGLGPHFAGRNATHQMKKMTLEDLKLFRDELRIPISDAD
                     LERDPYLPPYYHPGPDSPEIQYVVERRRQLGGFVPERRGKSTALVLPGDKVYETIRKGS
                     GKQEVATTMAIVRLIKDLIKDPEIGGRIVPIIPDEARTFGMDAMFPSQKIYNPHGQLYT
                     SVDAKLMLAYKESEHGQILHEGINEAGSTASFTAVGTSYATHGEPMIPVYIFYSMFGFQ
                     RTGDGLWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVSYDPAWAF
                     EISHIVKDGLRRMYGDNAENVFYYLTIYNEPVQQPAEPENLDVEGLLRGLYRYATAPGA
                     TGPRAQILVSGVTMPDAMRAQALLAEEWGVQADVWSATSWAELRRDAVEVDRHNMLHPE
                     AEPRVPYVTQVLSEAAGPVVAVSDYMRAVPDLIRPWVPSDMVSLGTDGFGFSDTRPAAR
                     RHFLVDAQSIVVAALTALARRGEIDHAKVVEATRRYKLDDPQAAGPQTTDSGAA"
     gene            8014..8622
                     /locus_tag="JJ691_RS28030"
                     /old_locus_tag="JJ691_55990"
     CDS             8014..8622
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="JJ691_RS28030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_55990"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_211762609.1"
                     /transl_table=11
                     /translation="MDGLTRGFSGLLVLHELSFELAPGEGAAVIGPNGSGKTTLLRCVA
                     GTDLPDAGRITLNGFPVLETSPDTRAAMACVLDDVDFFPDLSVGEHLALCALAHGQPDA
                     EAAVEAVLDELGITDQRDQLPATLSSGQRRRLALASCFVRPRSLLVLDEPEQRLDVEGR
                     AWLAAKLNAEKAAGSSVLMASHDPELIEAVADLYIEVGL"
     gene            8619..10004
                     /locus_tag="JJ691_RS28035"
                     /old_locus_tag="JJ691_56000"
     CDS             8619..10004
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039718.3"
                     /locus_tag="JJ691_RS28035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56000"
                     /product="DUF6297 family protein"
                     /protein_id="WP_211762610.1"
                     /transl_table=11
                     /translation="MTVVTARAVRAELRAMRRRRNPRSIFRRIYDLSDTALYIGMAGGL
                     VTEAVIKTQSASALSLAPAPHTAASVSWMAVAVALAAVAAFGHGLLAVGPIWAGSATQA
                     WILASPVDRRSALLPTFARTLLIASVAGALLAGGLTAVYPPWLVNLPTTGIIGFELGLA
                     LVCFTAGAQTSPREVRRFQAALVVLLGVAVLMGGVVALQLDVPDLPVPLDRLPWAVIVL
                     VVIALVIGYRALSQLHRGSLSAGADLVLAASVSSTWLDFSLLTSALALRRARRIGRVRS
                     VRLRGSRAVAFVLADLARLRRYPATVAMWVALLPVPFFAAISLPPIAVGPVQLLAAYIA
                     ADRFAGGLRTICGSAALRRALGGTDASLKIIHLVLPAAGAVLWCALTTFALPIAPTTTT
                     VISAAGAVVVVYAMATRPPMTYVGPAFDSPFGSMPVNLIRQLVRGPAVLVGLVALQLIA
                     TVA"
     gene            complement(10001..10783)
                     /locus_tag="JJ691_RS28040"
                     /old_locus_tag="JJ691_56010"
     CDS             complement(10001..10783)
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="JJ691_RS28040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56010"
                     /product="lanthionine synthetase LanC family protein"
                     /protein_id="WP_211762611.1"
                     /sec_met_domain="LANC_like (E-value: 2.1e-08, bitscore:
                     32.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLATLLAGSSDRAAQAAVRSAVPAWLDAAVRPMQCVGLHGGMAGT
                     LFGLSLIAELHPPVSQLSHRVSGWLGERRFEEFDLISGAAGACLAGYPQPVWFDGEDTG
                     MAHGAAGVLVVSPQPELVDWLLEQSFVDQRRQGWCYGMPGIAWALWTAGARAEAMRYLR
                     ILSQTFDPEVNLYGRDADRLGICHGAAGVMLIADAFVHAGVGAARGLRDQMWAYLVERL
                     DVVPTLDETLLMGASGVLAALLTVDGAGRRWLRCLGLR"
     misc_feature    complement(10813..10832)
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 23.24"
                     /tool="antismash"
     gene            complement(10902..13079)
                     /locus_tag="JJ691_RS28045"
                     /old_locus_tag="JJ691_56020"
     CDS             complement(10902..13079)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="JJ691_RS28045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56020"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_211762612.1"
                     /transl_table=11
                     /translation="MSELASESFNAERPRTRTPSALLRVAGLPIRLWTAAGNPDLVTDL
                     RELLAEEEAYAAYARSLADWVGALIPAAEDRAELLVLRRDLHNGRPVCSALPELARATA
                     WSTALGLRRAALDEDIERERERLRGLPWRLVDETVARAVPELVADVGRRLDAGEDWGGK
                     RLRQRSEYLLRMIARGTAKPTPRGWLAHVGRVEVAETASWPVVGECSAQWVSNVNADRR
                     QATLADGTITMNGLTWVDGDRLRCWSTTRVVEVRRTPLLDAIRNVLADGVHDVDELVRR
                     LAPDAGDVLRGFLQHLVGLGIVQLSRPPRTSWNVPLDGFVDVYRRVQGALPVDFVARTS
                     ELALQALRLADVLPRPVEHPILATVGSAPRPVTDLVAEYLAGEPMPETNRRRSPDLPEV
                     LTPQALDQLGLLPAALPEWPLDCLVRPMARGAVLEAIMPAGVVDARFAAALTELGGEPP
                     QVSSYRDFLARSAAEEGAKPVEILVPPLDDRAANAVRRPFYCPLWTGDADAAAYLPAAG
                     RYLSLGRITLRREGNRVIAEDVGGNLLWPMHHATRTPIGPWGLVVTLLTAAAPRGRSIS
                     FGNRMAAFPERDHLPRLEIAGGLVLSGRHWRIRPPSTFRELAGLDLPRFVFARAGGSKP
                     RPVDLHSLAASRELARLGDPVVLEEMLPDPDHLPLRDHHGEPIAGQLLLRLPHRRATTA
                     VAVGNQEGDSGWNPSWPSTNWTVSSRNWTPG"
     gene            complement(13076..13828)
                     /locus_tag="JJ691_RS28050"
                     /old_locus_tag="JJ691_56030"
     CDS             complement(13076..13828)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="JJ691_RS28050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56030"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_211762613.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 1.2e-11, bitscore:
                     43.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSQQERLTFLSGGLAALRDGAAPTWTQLGLSRPKPGIYGELAAA
                     VREMLAADRITDFFFMHKAPGLRVRFAAAPGLEPWVRAEANRLARRWREQGLIDGIVPG
                     VYEPEAVLFGGPAAMPHVHRLFTADSVAWLDHHARPELPAWLVSMRQLRSVFGGLGLCC
                     QAWPHVRDTCGRRVSLRDDSVAIACTELRGVWETTRSTAAPAARSWRVAVERAGVDPAE
                     VAAYYVVFHWNRARLSSARQALITEALA"
     gene            13934..14806
                     /locus_tag="JJ691_RS28055"
                     /old_locus_tag="JJ691_56040"
     CDS             13934..14806
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020494621.1"
                     /locus_tag="JJ691_RS28055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56040"
                     /product="polysaccharide deacetylase"
                     /protein_id="WP_211762614.1"
                     /transl_table=11
                     /translation="MVTGQPWEWPETVWRRETGRVRAGRSLRPSSWPDGRQAAVALSFD
                     SDHETIPLRDAEFSPCQLSQGEYGSRVGVPKILNLLARHGIPATFFVPAVSALLHPADI
                     DAYVRAGHEVALHGWIHERNTALPPGVERDLALRAADTLERLAGTRPVGLRTPSWDFSA
                     DTLAVIRELGLRYDSSLMADDDPYEVVADGEPTGLVEIPVEWIRDDAPFFPRDPTRPSV
                     PPRQVLTTWRDEFDAAYADGGLFQLTMHPHVIGHRSRFVALRQLVEYIAGHNVWFASHA
                     DVAGWCLRE"
     gene            complement(14768..15415)
                     /gene="pnuC"
                     /locus_tag="JJ691_RS28060"
                     /old_locus_tag="JJ691_56050"
     CDS             complement(14768..15415)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015663 - nicotinamide mononucleotide
                     transmembrane transporter activity [Evidence IEA]"
                     /GO_process="GO:0015890 - nicotinamide mononucleotide
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene="pnuC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016336119.1"
                     /locus_tag="JJ691_RS28060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56050"
                     /product="nicotinamide riboside transporter PnuC"
                     /protein_id="WP_211762615.1"
                     /transl_table=11
                     /translation="MNWLLEHGLTLLGEHISFAELLGQIGAVAVVFLAQRRTLWTWPVQ
                     IAAAVLLFSVYTSAHLGGLALRQVIVFAISLYGWWAWTRRRDAEYGVLVRRSTWPELGA
                     LAAALVLGTIGMALLLQATNGSWAPWPDAAIFIGTAVAYAAQGLRLVEFWLVWLLVDAI
                     GVPLQIASGLYFSASVYIVFTALVIKGWRDWTRSAKAAAASLAQAPAGNVSV"
     misc_feature    15464..15479
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.74"
                     /tool="antismash"
     regulatory      complement(15480..15610)
                     /bound_moiety="flavin mononucleotide"
                     /db_xref="RFAM:RF00050"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00050"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="FMN riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     gene            complement(15665..16450)
                     /locus_tag="JJ691_RS28065"
                     /old_locus_tag="JJ691_56060"
     CDS             complement(15665..16450)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004559013.1"
                     /locus_tag="JJ691_RS28065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56060"
                     /product="hypothetical protein"
                     /protein_id="WP_211762616.1"
                     /transl_table=11
                     /translation="MGDQLSQGLGDAWALITTFVPKLLGFLIVLLVGWLVAKALSKAVE
                     LLLGKVGFGRLVERSGLGGPKSPVDAGKLIVQLVFYFVMLIALNYAFGVFGTGNPVSDL
                     LNQVIAYLPRVVVAIILVLIASAIARVVRTLITGALAGRQYGQLLGTVSYAFLLALGVI
                     AALNQLGIATTVTEPVLIFALATVGGILVVGVGGGMVRPMQSRWEQWLTRAQAEAASRP
                     ADGSAQDAPWERNQPPGSDTPTPAQGFPRPDPDQQSRPE"
     gene            complement(16886..18412)
                     /locus_tag="JJ691_RS28070"
                     /old_locus_tag="JJ691_56070"
     CDS             complement(16886..18412)
                     /NRPS_PKS="Domain: Abhydrolase_1 (79-274). E-value:
                     2.3e-21. Score: 68.4. Matches aSDomain:
                     nrpspksdomains_JJ691_RS28070_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012770.4"
                     /locus_tag="JJ691_RS28070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56070"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_211762617.1"
                     /sec_met_domain="PF00561 (E-value: 1.6e-26, bitscore: 92.8,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEEVDLRRLLPVALSLLAVVSLVTPAQAQRVVWGPCSGALAALEC
                     ATLSVPLDYVHPDQGTIAVMVSRRPAADPAHRKGVLLINPGGPGGSGLSMPRYIADHTP
                     LGQYYDLVGFDPRGVGSSTALRCLTPRGLAGLESRPADDQFAAWAADARSTEDACKRSG
                     GGIRPFIDTRDTARDMDQIRDALGVAKINYLGYSYGTYLGAVYGSLFPDRLNLSVLDSS
                     VHPEWIWRRQFMEQAAAYRSDVDSWAAWVGDRNGAFGLGVGRAAVLVSVEQLASTLAKS
                     PVGKFTRSTLDGAVGEGARYRPLWSDLAQVLVSLRKGDHVAVGDAVGAGTALAQRGLDA
                     LQSGVFDTVTCEADWPTDVTTYYQDMRIYRDAFPYGYGVLRAAPTTCTYRSFTPAEPPV
                     SLARRGYPVGVVVQGEGDTQTEYAGGPAMAQRLRDNLITVSDEGAHGQYGTNPCATEKI
                     NRYFVDGVLPDSSSVCPGSPRPDVPADTLPARSATLGQSVHNYLSALAPF"
     aSDomain        complement(17591..18175)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS28070_Abhydrolase_1.1"
                     /evalue="2.30E-21"
                     /label="JJ691_RS28070_Abhydrolase_1.1"
                     /locus_tag="JJ691_RS28070"
                     /protein_end="274"
                     /protein_start="79"
                     /score="68.4"
                     /tool="antismash"
                     /translation="VLLINPGGPGGSGLSMPRYIADHTPLGQYYDLVGFDPRGVGSSTA
                     LRCLTPRGLAGLESRPADDQFAAWAADARSTEDACKRSGGGIRPFIDTRDTARDMDQIR
                     DALGVAKINYLGYSYGTYLGAVYGSLFPDRLNLSVLDSSVHPEWIWRRQFMEQAAAYRS
                     DVDSWAAWVGDRNGAFGLGVGRAAVLVSVEQL"
     gene            18499..19689
                     /locus_tag="JJ691_RS28075"
                     /old_locus_tag="JJ691_56080"
     CDS             18499..19689
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014466762.1"
                     /locus_tag="JJ691_RS28075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56080"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_211762618.1"
                     /transl_table=11
                     /translation="MGDLAWDSLSTETLRRLEHASGRLATGTIGEMERRLPWFRRLPAD
                     QRASVLMVTQSGVAGFVSWLRDNKQAIRLTAEAFRSAPKDMSRWVSLRQTVELVRVALE
                     VFEQMLPDIAADEKERGQLTEAVLRYGREIAFAAATSYAAAAEARGAWDARLEALIVDG
                     IVRGDAEESLLSRASALGWQQAAEATVLVGNPMSAEPTRVVFDVRSRAARIHRPVLLSV
                     QGSRLVVVLGGSEDEARGQEVLAKMAEAFGPGPVVVGPTVDSIAEAHRSASDALSGLRA
                     VVGWPTAPRPVRSLDLLPERALAGDPEAEWQLIERIARPLEEATGGLMATVDAFLETGG
                     VLEACARNLFVHPNTVRYRLKRVTELTGRNANDPRDALVLRVALTVGRLAKARGLW"
     misc_feature    19771..19787
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 17.97"
                     /tool="antismash"
     gene            19840..20775
                     /locus_tag="JJ691_RS28080"
                     /old_locus_tag="JJ691_56090"
     CDS             19840..20775
                     /EC_number="2.3.1.39"
                     /GO_function="GO:0004314 - [acyl-carrier-protein]
                     S-malonyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_AT (11-291). E-value: 3e-48. Score:
                     156.6. Matches aSDomain:
                     nrpspksdomains_JJ691_RS28080_PKS_AT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800169.1"
                     /locus_tag="JJ691_RS28080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56090"
                     /product="ACP S-malonyltransferase"
                     /protein_id="WP_305875444.1"
                     /sec_met_domain="PKS_AT (E-value: 5.2e-46, bitscore: 156.6,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFSDLVIALLAPGQGSQAPGMLAPWLELDGVAELVAGWSETTGLD
                     LARLGSTADAEEIKDTAITQPLIVALTLVAFRELQRRVPVPAAAPVAGHSIGELAASAI
                     AGVLSMDDAVALAAVRGRAMAEACALEPTGMAAVMGGEADELLARLDEYGLVPANRNGA
                     GQTIAAGSLTALQKLADERPAGTKVVMLKVAGAFHTHYMDPARETLREKVAGVATADPN
                     RPLLSNADGSVVTSGSEMLGRLVAQVTLPVRWDLCMDTLARSGVTTTIELAPGGALTGL
                     VKRQLKDVVTKPIAIKTPADLDKAVEAVQQ"
     CDS_motif       19873..19905
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS28080_0001"
                     /evalue="3.90E-03"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="JJ691_RS28080"
                     /protein_end="22"
                     /protein_start="11"
                     /score="10.3"
                     /tool="antismash"
                     /translation="PGQGSQAPGML"
     aSDomain        19873..20712
                     /ASF="(Methyl)Malonyl-CoA specificity inconclusive"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS28080_PKS_AT.1"
                     /evalue="3.00E-48"
                     /label="JJ691_RS28080_PKS_AT.1"
                     /locus_tag="JJ691_RS28080"
                     /protein_end="291"
                     /protein_start="11"
                     /score="156.6"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="PGQGSQAPGMLAPWLELDGVAELVAGWSETTGLDLARLGSTADAE
                     EIKDTAITQPLIVALTLVAFRELQRRVPVPAAAPVAGHSIGELAASAIAGVLSMDDAVA
                     LAAVRGRAMAEACALEPTGMAAVMGGEADELLARLDEYGLVPANRNGAGQTIAAGSLTA
                     LQKLADERPAGTKVVMLKVAGAFHTHYMDPARETLREKVAGVATADPNRPLLSNADGSV
                     VTSGSEMLGRLVAQVTLPVRWDLCMDTLARSGVTTTIELAPGGALTGLVKRQLKDVVT"
     CDS_motif       20110..20214
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS28080_0002"
                     /evalue="1.10E-14"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="JJ691_RS28080"
                     /protein_end="125"
                     /protein_start="90"
                     /score="46.5"
                     /tool="antismash"
                     /translation="VAGHSIGELAASAIAGVLSMDDAVALAAVRGRAMA"
     gene            20772..21758
                     /locus_tag="JJ691_RS28085"
                     /old_locus_tag="JJ691_56100"
     CDS             20772..21758
                     /EC_number="2.3.1.180"
                     /GO_function="GO:0004315 - 3-oxoacyl-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0033818 -
                     beta-ketoacyl-acyl-carrier-protein synthase III activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020657584.1"
                     /locus_tag="JJ691_RS28085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56100"
                     /product="beta-ketoacyl-ACP synthase III"
                     /protein_id="WP_211762619.1"
                     /sec_met_domain="fabH (E-value: 2.5e-93, bitscore: 312.0,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSERPSLIGRTGPAGTRLLGFGSAQGNRVVTNDDIAAMGVDTNDE
                     WIRQRVGIVERRLCDPDQTLVDLAVAAGANALADSGVAAGEIDTVLVATCTMPGNIPNA
                     AAQTADRIGVSSPAAFDLNAACAGFPYSLTVASDMIRGGSANKVLVIGAERFTDWVDWS
                     DRGNCIIFADGAGACVVGPADEPLIAPAVLGSSGDLVDMIGLTPAGHIFQEGQSVFRWA
                     TTQIAPIAERAVEAAGVKLSDIDVLVPHQANLRIVEHIAKKLRAKGARDDMVVADDIVH
                     SGNTSSASIPMAIDHMRADGRISSGDVMLLVGFGAGLSYSGQVAICP"
     gene            21823..22062
                     /locus_tag="JJ691_RS28090"
                     /old_locus_tag="JJ691_56110"
     CDS             21823..22062
                     /NRPS_PKS="Domain: PP-binding (9-75). E-value: 5.1e-19.
                     Score: 60.3. Matches aSDomain:
                     nrpspksdomains_JJ691_RS28090_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009947996.1"
                     /locus_tag="JJ691_RS28090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56110"
                     /product="acyl carrier protein"
                     /protein_id="WP_211762620.1"
                     /sec_met_domain="PP-binding (E-value: 6e-17, bitscore:
                     61.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding_2 (E-value: 0.036, bitscore:
                     13.5, seeds: 2, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNEEIRTGLAEIVEEVAGVAVDDVTVEKSFVDDLDIDSLSMVEI
                     AVQAEDKFGVKIPDDELANLKTVGDAVNYIASNA"
     aSDomain        21850..22047
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS28090_PP-binding.1"
                     /evalue="5.10E-19"
                     /label="JJ691_RS28090_PP-binding.1"
                     /locus_tag="JJ691_RS28090"
                     /protein_end="75"
                     /protein_start="9"
                     /score="60.3"
                     /tool="antismash"
                     /translation="LAEIVEEVAGVAVDDVTVEKSFVDDLDIDSLSMVEIAVQAEDKFG
                     VKIPDDELANLKTVGDAVNYI"
     misc_feature    complement(21851..21865)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.92"
                     /tool="antismash"
     gene            22100..23332
                     /locus_tag="JJ691_RS28095"
                     /old_locus_tag="JJ691_56120"
     CDS             22100..23332
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (61-405). E-value:
                     3.9e-48. Score: 156.3. Matches aSDomain:
                     nrpspksdomains_JJ691_RS28095_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FabF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015800166.1"
                     /locus_tag="JJ691_RS28095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_56120"
                     /product="beta-ketoacyl-[acyl-carrier-protein] synthase II"
                     /protein_id="WP_211762621.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.7e-57, bitscore:
                     193.0, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="FabF (E-value: 2e-167, bitscore: 556.4,
                     seeds: 4, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSVDVVVTGVGATTPLGGDVASTWDGLLAGRSGVSTLDADWVHK
                     YELPVQIAAQLKVQPTEILPRVEARRLDRSEQVAMVASRQAYSDAGLDEDAVDPERLAV
                     IIGTGIGGALTLLAQDDLLETAGLRKVSPLTVPMLMPNGPAAHVGLTLKARAGVHAPVS
                     ACASGAEAIAWAYRMIRSGEADVVVAGGAEACITGITMAGFAQARTMSTRNSAPEQASR
                     PFDVERDGFVLGEGAGIMVLERADHAKARGAKVYGRLAGIGTSSDAYHITGPDPEGNGQ
                     LRAIKAAMRSGELAAEDIGHVNCHATSTPVGDTIESIAIHRAIGDHPLLTAPKGSLGHL
                     LGASGAVEAIATVLSIRDGVIPPTANLQTPDPALLHEVVAGEPRRVELKAAINDSFGFG
                     GHNVALAFAKV"
     aSDomain        22283..23314
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS28095_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.90E-48"
                     /label="JJ691_RS28095_PKS_KS.1"
                     /locus_tag="JJ691_RS28095"
                     /protein_end="405"
                     /protein_start="61"
                     /score="156.3"
                     /tool="antismash"
                     /translation="EILPRVEARRLDRSEQVAMVASRQAYSDAGLDEDAVDPERLAVII
                     GTGIGGALTLLAQDDLLETAGLRKVSPLTVPMLMPNGPAAHVGLTLKARAGVHAPVSAC
                     ASGAEAIAWAYRMIRSGEADVVVAGGAEACITGITMAGFAQARTMSTRNSAPEQASRPF
                     DVERDGFVLGEGAGIMVLERADHAKARGAKVYGRLAGIGTSSDAYHITGPDPEGNGQLR
                     AIKAAMRSGELAAEDIGHVNCHATSTPVGDTIESIAIHRAIGDHPLLTAPKGSLGHLLG
                     ASGAVEAIATVLSIRDGVIPPTANLQTPDPALLHEVVAGEPRRVELKAAINDSFGFGGH
                     NVAL"
     CDS_motif       23003..23047
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS28095_0001"
                     /evalue="9.00E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="JJ691_RS28095"
                     /protein_end="316"
                     /protein_start="301"
                     /score="9.0"
                     /tool="antismash"
                     /translation="VNCHATSTPVGDTIE"
ORIGIN
        1 tcagcggcgg cgcgtccgcc agccccgccg atcgctggac gttgaccgag ggcagcggca
       61 ccaccgccgc agacaccaca gccgcgcgcc caatcacctt gaccgccggg acgacctggg
      121 gcacagatcc agtacacggc aaggtcctcg gtctagacgg ctctggcggc tatggcacga
      181 caggccgtcc cgcgttgaac acgacgagct cgtattcggt gtcggcctgg gtcaagctca
      241 acaacaccga caactactcc accatcgcca gccaaggcgg caccaacgcc gccagcttct
      301 acctccaata caacaagcaa ctcaacgcct gggccttcat cagccccagc ggcgactccg
      361 gcaacccggc cagctacgcc accgcacaga gcagcagccc acccgcactc acgtggacca
      421 acctcgtcgg cgtctacaac gctgacgacc actccatgac cctctacgtc gacggacaac
      481 aggccgggaa aaccaccaat cccacaccat gggccagcac cggccccttc accatcggcg
      541 ccgccaagac cgccaacagc accggcgact acgtcaacgg ctcggtcagc gacatccaga
      601 cctacgccag ggcgctagcg ccttccgagg tcgcctcgat ccatgcgacc gcgaccgtct
      661 cggtcaaccc gatggcaccc ggcacgcact acctgtacgc gtacgcggcc gatgccgccg
      721 gcaacgtctc cgagtcgcag tcgtacgaat tcctggccgc tggcaacccg aacgtgtcgt
      781 gcggcacgtt cgaccagtgc gtggcgaacg accccgcaca gaacatcgcg atcacgtcca
      841 actccgcccc caacctgggc aaggcggacg gcaccaacag cttctccgcc gatgacctga
      901 aggccgcggg ctggcagcca gggggcaagg tcactgtcga cggcgccacg ttcaccttgc
      961 cgcaattcgg cggcgacaag ccggacaacc tgcttgctgc caaccaaact gtcacgtact
     1021 ccagcggcat accttcctac ggcacgacat cgctggtgtt tctggccacc gcgacaaacg
     1081 cgaagatgac cgccaacgat gttcaagtcg ccgccactgg gacattggca gcaccggggg
     1141 tgccgtccga catcagtgtg gccggctcct actgcttcac gggacccaag tcaccgggca
     1201 catgtgccgc ccaaggcgtc atcaccacgg cgaacacatc cggcggctcg caacgcaact
     1261 cggcttactc gcttcccgtg ccggactgga tcaccggccc cgacgcgctc gccgcggtca
     1321 agctgccgcg tgagaacaca cgctcgggcc agaacaccac gaacagcccc aagatctacg
     1381 ccttcgctgt tccgctgcca cccagcgaag ccggccgaca gatcaccagc gtgaccctgc
     1441 cggatgtcag caacgacgcc ttcggacagg ccatgcacat cttcgcgatg gccacccgca
     1501 acaccacctc gatcgacaag gacacctcgt ggaccggggc ctgggggagc cccaatgaag
     1561 gccagcacac ccagcaggga gggaacttca ccaaccagac gttccgcatc gcgctcaagc
     1621 cttcgctcgc gggcaacacc gtgcgcatca agctcgacaa ctccctcggc acgagcccgt
     1681 tgaccatcaa tagcgcgacg atcgcgacga gctccaccgg cagcacacgt tcggccacag
     1741 ccgctgcgga tctggtgccc ctggccttcg gcacatcgcc gtcgctcacg atcccagcgg
     1801 gtggcatggc ctacagcgat gccaaacagt tcgctgtcag tcccaaccag tacgtgctcg
     1861 tgtccttcag cctgtccagc tcggtgtcgg tgccctacct cgtcgagcac acatggtcga
     1921 acaacgcatg ggagtacacg acatcgcccg gcgctgggga caagtccggg gtgacgagcg
     1981 gcgcggtgtt cgatggaacc aacggcgcct tcaccaactt gctcaccggg ctggacgtca
     2041 cgaccaatca cgtcggcacc accgtggtcc tcggcgacgg cctgatcgac gcgcccagca
     2101 ctcaccccta cctcgaaagc gacctcgcgg ccgtcctgtc cgccgccgaa ccgaccacac
     2161 ccgcgcccta cggcgcggtc agcgccggca tcgagtccaa tgaggtgacg accgactacg
     2221 cccagccctc agccgacagc agggtcggcg gcccctccgc gctctcccgg gtcgatcgag
     2281 atcttctcgc ccaaccagga gtcacgaccg tcgtgctgta cgaaggactc caagacattc
     2341 tcaaccacaa gaccgccagc gaggtggacg cggcgtacgc gcaactcgag agctacctgt
     2401 acagcgctgg gatcacaacc atcgccatcg ggctgactcc ttgcgtcggc tacgcgggca
     2461 gagggggatc gaccaacgac ccctgtacca ccgacgtgga cacgcagcgt gggatcatga
     2521 acgccttcct cagcaatggc gccggactcc ccagcaaaaa tccgcagtac ttctacatca
     2581 cgcccgatcc ggtgatcggc caatccgact cggccaccgg cagcacggtg ctggacccga
     2641 acgcgtcgat gagtgatcac gtcaacctct tcgccaccgg ctacgccgct ctaacgtcgg
     2701 catacctggg accacacgac acctggcagc tcaatgacgg cgccagcgca ccggagaccg
     2761 cctcgacgac agcacgtgac accgccccga caaccaagac gccctggttc caacaggaca
     2821 gtggcgttgg acagtccccg ggcacactgc acggatcgac gtcctggacc gacgacccag
     2881 cgcgcggcaa tacgctccaa ctcgacggct cgaccggtta tgtcgaaacc ggcggaccgg
     2941 tgctgaacac gaccaagagc ttcagcgtgt cggcgtgggc caacctcgcc aacacgagca
     3001 acgacgcggt catcgccagc caggacggca gccagaactc cgcgttcaca ctgaagtacg
     3061 acgccgccgc acagcggtgg gcattcacca tgtccgcgac ggacacggca ggcgccacgc
     3121 agatcaaggc cgtctcccag ttcgccccga ccaccggcgc atggacgcat ctggtcggca
     3181 cctacaacgc cacaaccgga accctgtccc tgttcgtcaa cggcgccgcc caaggcaccg
     3241 cccataacac cacccccttc accgccagcg gcccgctcgc catcggccgg ggactcagca
     3301 acgccaccaa caccggcttc ttctccggca agctcagcaa cgttcagacg tggtcgtact
     3361 ccctggcccc agcccaggtc cttgccctga accagcagat cagctgagta gacgtcagtg
     3421 ggggtgggtc caagtctcag gccccacccc cactgacaaa ttcggctggc ttcagggacc
     3481 agcgcgttgt cccgtagtcg tttcgcagca tcgactacac cgtcatgcgt ggcgaatcgc
     3541 tcatggcggg cgatgccgcg aacctcgact gcggcctcgt gtatcgttca ctctcgtgtt
     3601 caggggcgca tagctcaggg gtagagcacc gctcttacaa agcgggggtc gcaggttcga
     3661 aacctgctgt gcccacactc tctgatccac gcgggacacg tgtgcttgtg ccacgactcg
     3721 cgccacggct gcgactgcat acgcccggac gcgcggctga cgtgcgcgga agtcaccttt
     3781 cggtctagtg accacccgct cgacaaggcg gatgctctcc cgctgagcta tgcgccctgg
     3841 cacccgggcc ggttctggcc ggcccgggtg tcatggtctc acgtcagagc gacttgaggg
     3901 cccgcttcca ctggtcctgg tcgcgggctt cgccgggctg gttggcttcg gcgaagcgga
     3961 tgacgccctg cttgtcgatg aggtacgtgc cgcgcagggc catgccggcc ttgtcgttga
     4021 acacgtcgta ggcctgggcg gtggccccgt gcggccagaa gtcggagagc agcgggaagg
     4081 agtagccctc cttctcggcc cacgccttca ggctgaacgg ggtgtccacg gacactccga
     4141 tgacctgcac ctcgtcgttc tggtactcgg ccagttcgtc ccgcacctgg cagagttcgc
     4201 cggtgcagat gccgctgaag gcgaacgggt agaacaccag cagcacgttc ttctcgccgc
     4261 ggaacgacga cagggtcacg tcttccctgt tggcgtcctt gagcgtgaag tcaggggcct
     4321 gggtaccgac ttccagcgcc atgctcgcgc tacctcccgg tgggctcggc agttacccgc
     4381 caagcctatg ccaccgggtg ggaggtctca gcgcttggtc ttggccgact tgggcgacac
     4441 gagcttgatg cccgcccagt cctcgccgac gctcgcgttg agggtctggg cgaggccggc
     4501 ggtgggcacc gcttcggcga tgtcgctggg ctcgacgtag ccggggcgtc ccgtcttggg
     4561 ggtgagcacc cagatgacgc cgtcctcggc gagcggcccg gtcacgtcca tcagcgtgtc
     4621 gaccaggtcg ccgtcgctct cccgccacca cagcagcacg acgtcgacga cctcgtcgga
     4681 ctcctcgtcg agcaggtcac tgccgatccg ttcctcgatc gcggcgcgca cgtcgtcgtc
     4741 gacgtcctcg tcccaaccga tctcctggac caccatgtcc ggctcgatcc cgagcctgtc
     4801 ggcgacgccg accttgccag cgtctcccgc ggccaccacg gcttccactc ctccaagcta
     4861 tgccagtagg gcgactgggg tcagccgcca cacctgtatt caacaccggt cgcgcacagc
     4921 gaacactgag ggtggccacc tgcgcaacca cccacaccgt gacacaccga agacgggctc
     4981 gggattcgac cccgctttgc cacccgttcg gggcatcagg caggctctac atacctccta
     5041 tacgcgcgcg cgagggagct accgaccggt agcacggagt cgtagggatc tgcgagcgcc
     5101 gaatgaggga ggatggacgt gaacctgtcg acaacaccag gcgaggagac cccttggccc
     5161 cgcagagcaa cggcgctggc agtgcgagcc ccccggagcg ggtccgggtc atccgcgacg
     5221 gcctcgccgc ccacctcccg gacatcgacc ccgatgagac cgcggagtgg cttgagtcct
     5281 tcgacggcgt gctgaagggc gccgggcagc agcgcgcccg gtacctgatg ctgcggctgc
     5341 tggagcgggc ccgcgagagc cgggtgggcg tgccgtcgct gaccagcacg gactacgtga
     5401 acaccatccc gaccgagcag gagccctggt tccccggcga tgaggagacg gagcgccgct
     5461 accgggcgtg gatccgctgg aacgcggcca tgacggtgca ccgcgcgcag cgtccgggcg
     5521 tcggcgtggg cgggcacatc tccacgtacg cgtcctcggc gacgctgtac gaggtcggct
     5581 tcaactggtt cttccgcggc aaggaccacc cgggcggcgg cgaccaggtg tacttccagg
     5641 gccacgcctc gccgggcatg tacgctcgcg cgttcctgga gggccggctg tcggccgagc
     5701 acctggacgg cttccgccag gagtattcgc acgccggccc gggcggcggt ctgccgtcgt
     5761 acccgcaccc gcggctgatg ccggacttct gggagttccc gacggtctcg atgggcctgg
     5821 gcccgatgaa cgcgatctac caggcgcggt tcaaccgcta cctgcgcgac cgcggcatca
     5881 aggacacgtc ccagcagcac gtgtgggcgt tcctgggcga cggcgagatg gacgaggcgg
     5941 agtcgcgcgg cctgatccac gtggccgcga acgagggcct ggacaacctc accttcgtga
     6001 tcaactgcaa cctgcagcgg ctggacggcc cggtccgcgg caacggcaag atcatccagg
     6061 agctggaggc gttcttccgg ggcgccggct ggaacgtcat caaggtggtc tggggccgcg
     6121 agtgggactc gctgctgcac gccgaccgcg acggcgcgct gatcaacctg atgaacacca
     6181 cgccggacgg cgactaccag acgtacaagg ccaacgacgg cgcctacgtg cgtgagcact
     6241 tcttcggccg cgacccgcgc accaaggagc tggtcgcgcc gatgagcgac caggacatct
     6301 ggaacctcaa gcgcggcggc cacgactacc gcaaggtgta cgcggcgtac aaggcggcca
     6361 ccgagcacaa cggccagccg acggtcatcc tggccaagac catcaagggc tacggcctgg
     6421 gcccgcactt cgccggccgc aacgccacgc accagatgaa gaagatgacc ctggaggacc
     6481 tcaagctctt ccgggacgag ctgcgcatcc cgatcagcga cgcggacctc gagcgcgacc
     6541 cgtacctgcc cccgtactac cacccggggc cggactcgcc ggagatccag tacgtcgtcg
     6601 agcgccgccg ccagctgggc ggcttcgtgc cggagcggcg gggcaagtcc accgcgctgg
     6661 tgctgccggg cgacaaggtc tacgagacga tccgcaaggg ctcgggcaag caggaggtgg
     6721 ccaccacgat ggccatcgtc cggctgatca aggacctgat caaggacccg gagatcggcg
     6781 gccggatcgt gccgatcatc ccggacgagg cgcggacctt cggcatggac gccatgttcc
     6841 cgtcgcagaa gatctacaac ccgcacgggc agctctacac ctccgtggac gccaagctga
     6901 tgctggccta caaggagagc gagcacgggc agatcctgca cgagggcatc aacgaggccg
     6961 gctcgacggc gtcgttcacc gcggtcggca cctcgtacgc cacccacggc gagccgatga
     7021 tcccggtcta catcttctac tcgatgttcg gcttccagcg caccggcgac ggcctgtggg
     7081 cggccgccga ccagatggcc cggggcttcg tgctgggcgc caccgcgggc cgcaccacgc
     7141 tgaccggcga gggcctgcag cacgccgacg gccactcgct gctgctggcg gcgaccaacc
     7201 cggcggtggt gtcctacgac ccggcctggg cgttcgagat ctcccacatc gtcaaggacg
     7261 gcctgcggcg gatgtacggc gacaacgccg agaacgtctt ctactacctg acgatctaca
     7321 acgagccggt gcagcagccg gccgagccgg agaacctgga cgtcgagggc ctgctgcgcg
     7381 gtctgtaccg ctacgccacg gcccccgggg ccaccggccc gcgggcgcag atcctggtat
     7441 ccggtgtcac catgcccgac gccatgcggg cccaggccct gctggccgag gagtggggcg
     7501 tgcaggccga cgtgtggtcg gcgacgtcat gggcggagct gcgccgcgac gcggtggagg
     7561 tggaccggca caacatgctg cacccggagg ccgagccccg cgtgccgtac gtgacgcagg
     7621 tgctgtccga ggcagccggc ccggtggtgg cggtgtcgga ctacatgcgc gcggtgccgg
     7681 acctgatccg cccgtgggta ccgtccgaca tggtgtcgct gggcacggac ggcttcggct
     7741 tctccgacac caggccggcg gctcgccgcc acttcctggt ggacgcgcag tcgatcgtgg
     7801 tggccgcgct gaccgcgctg gcccgccgcg gcgagatcga ccacgccaag gtggtcgagg
     7861 cgacccgccg gtacaagctg gacgacccgc aggccgcggg tccccagacc acggactccg
     7921 gcgccgctta acctggtgcg cgaccaacgc cgagggaacc ggtaacggtt ccctcggcgt
     7981 tttcgtgtta ggggggtccg agcggtgttg cgggtggacg ggctgacgcg gggcttcagc
     8041 gggctgctgg tgctgcacga gctgagcttc gaactggcgc ctggggaggg cgccgcggtg
     8101 atcgggccga acggctcggg caagaccacg ctgctgcgct gtgtggccgg cacggacctg
     8161 cccgacgccg gccgcatcac gctgaacggg ttcccggtgc tggagacgtc gccggacacc
     8221 cgggcggcga tggcctgcgt gttggacgac gtggacttct tcccggacct ctcggtcggc
     8281 gagcacctgg cgctgtgcgc gctggcccac gggcagccgg acgccgaagc ggcggtcgaa
     8341 gcggtgctgg acgaactggg catcaccgac cagcgggacc agctgccggc gacgttgtcc
     8401 agcgggcaac ggcggcggct cgccctggcg agctgcttcg tgcggccgcg gagcctgctg
     8461 gtgctggacg agccggagca gcggctggac gtggagggcc gggcctggct ggcggcgaag
     8521 ctgaacgccg agaaggccgc cggatcgtcg gtgctgatgg cgtcgcacga tccggagctg
     8581 atcgaggcgg tcgccgacct gtacatcgag gtcgggctgt gactgtcgtc actgcccggg
     8641 cggtccgggc cgagctgcgg gccatgcggc ggcggcgcaa tccgcgctcg atcttccgtc
     8701 ggatctacga cctgtccgac accgcgctct acatcggcat ggccggcggc ctggtgaccg
     8761 aggccgtgat caagacccag tccgcgtcgg cgctgtccct cgcgccggcg ccgcacactg
     8821 ccgcgtcggt gtcgtggatg gccgtggcgg tcgctctggc ggccgtggcg gcgttcgggc
     8881 atgggctgct ggcggtggga cccatctggg ctggttcggc gacgcaggcg tggatcctgg
     8941 ccagtccggt ggaccgccgc tcggcgctgc tgccgacctt cgcgcggacg ctgctcatcg
     9001 ccagcgtggc cggggcgctg ctggccggcg ggctgacggc ggtctacccg ccgtggctgg
     9061 tgaacctgcc gacgaccggg atcatcggct tcgaactggg gctggccctg gtctgcttca
     9121 ccgccggcgc gcagaccagc ccacgtgagg tgcgccgatt ccaggccgcc ctggtcgtgc
     9181 tgctgggcgt cgcggtgctc atgggcggcg tcgtggcgtt gcagctggac gtgccggacc
     9241 tgcccgtgcc gctggaccgc ctgccgtggg cggtgatcgt gctggtggtg atcgccctcg
     9301 tgatcggcta ccgggcgctg tcgcagctgc atcgcggctc gctgagcgcc ggtgccgatc
     9361 ttgtgctggc tgccagcgtt tcctcgacgt ggctggactt ctcgctgctc acctcggcgc
     9421 tggcgctgcg ccgggcccgc cggatcggtc gggttcgctc ggtacgtctg cgcggcagcc
     9481 gcgccgtcgc cttcgtgctc gccgacctcg cccggctacg ccgctatccg gccaccgtcg
     9541 ccatgtgggt ggcgctgctg ccggtgccgt tcttcgccgc gatctcgctg ccgcccatcg
     9601 ccgtcggccc cgtgcaactg ctcgccgcgt acatcgccgc cgaccggttc gccggtggtc
     9661 tgcgcaccat ctgcggctcc gccgcgctgc gccgggccct cggcggcacc gacgcgtcgt
     9721 tgaagatcat ccacctcgtg ctgccggccg ccggggccgt gttgtggtgc gcgctaacga
     9781 ctttcgcgct gcccatcgcc ccgaccacaa ccaccgtcat ctcggccgcc ggggccgtgg
     9841 tcgtcgtcta cgccatggcc acccggccgc ccatgaccta cgtcggcccg gcgttcgaca
     9901 gcccgttcgg cagcatgccg gtcaacctga tccgccagct ggtgcgcggc cccgccgtgt
     9961 tggtcggctt ggtcgccctg cagctgatcg ccaccgtggc ttagcgcagg ccgaggcacc
    10021 gcagccagcg gcggccggcc ccgtcgacag tgagcagcgc ggccagcacg ccgctggccc
    10081 ccatgagcag ggtctcgtcc agcgtcggca ccacgtcgag gcgttccacc aggtacgccc
    10141 acatctggtc gcgcaggccg cgggcggcgc caacaccggc gtgcacgaag gcgtcggcga
    10201 tgagcatcac gccggcggcc ccgtggcaga tgccgaggcg gtcggcgtcg cggccgtaga
    10261 ggttcacctc gggatcgaag gtctggctca ggatccgcag gtagcgcatg gcttcggccc
    10321 gcgcgccggc ggtccacagg gcccaggcga tgccgggcat cccgtagcac cagccctgcc
    10381 ggcgctggtc cacaaaggac tgttccagca gccagtcgac cagttccggc tggggcgaga
    10441 cgaccagcac gccggcggca ccgtgggcca tgccggtgtc ctcgccgtcg aaccacaccg
    10501 gctgcgggta gccggccagg caggcgccgg ccgcaccgga gatcaggtcg aactcctcga
    10561 accgccgctc ccccagccag ccggaaaccc ggtgcgacag ctgggaaacc ggcgggtgga
    10621 gctcggcgat caggctgagg ccgaacaggg tgccggccat gccgccgtgc aggccgacgc
    10681 actgcatcgg ccgcacggcg gcatccagcc aggccggcac cgcggaccgc acggcggcct
    10741 gcgccgcgcg gtccgacgag ccggccagca gtgtcgcgag cacgcacgga cccagttccg
    10801 gcgagcccgc ggcccgggtc agcagtccca gcgactcatc tgacagccga ccagcgagca
    10861 gatcgccgag tccggcgcgc ggcccgccgg ggcgacctcg gtcatccggg agtccagttc
    10921 cgcgatgaga cggtccagtt cgtcgacggc caagacggat tccatccact gtccccttcc
    10981 tgattcccca ccgcgaccgc ggtggtggct cggcggtgcg gcagccgcag cagcagctgc
    11041 ccggcgatcg gctcgccgtg gtgatcccgc aacggcaggt ggtccgggtc cggcagcatc
    11101 tcctccagga caacgggatc gcccagccgg gccagctccc gcgacgcggc caggctgtgc
    11161 aggtccaccg gtcgcggctt gctgcccccg gcccgggcga acacgaagcg cggcaggtcc
    11221 agcccggcca gctcccggaa agtcgagggc ggtcgaatcc gccagtgccg cccggacagc
    11281 accagcccgc cggcgatctc cagtcgtggc aagtgatccc gctccgggaa ggcggccatc
    11341 cggttgccga aagagatcga ccggccgcgc ggagcggcgg cagtgagcag ggtgacgacc
    11401 agaccccacg gaccgatggg cgttcgtgtg gcgtggtgca tgggccacag cagattgcca
    11461 cccacgtcct cagcgatgac ccggtttccc tcacgccgca aggtgatccg tcccagcgac
    11521 agataacgcc cggccgccgg gagataggcg gccgcgtcgg catcgcccgt ccacaatgga
    11581 caatagaagg gtcttcgcac ggcgttggcg gcacggtcgt ccagtggtgg cacgaggatt
    11641 tcgaccggct tggccccctc ttcggccgcg ctacgggcca agaagtcccg gtaggaactc
    11701 acttgcggcg gttcgccgcc gagttcggtc aaggcggcgg cgaagcgggc gtccaccacg
    11761 ccggccggca tgatcgcctc caacacggca cccctggcca tgggccggac caggcagtcc
    11821 agcggccact cgggcagcgc ggccggcagc aggcccagct ggtcaagcgc ttgcggggta
    11881 aggacttccg gcaggtccgg cgatcttcga cggttggtct ccggcatcgg ctcgccggcc
    11941 aggtactcgg cgaccagatc ggtcaccggc cgcggcgcgg agccgacggt ggccaagatc
    12001 gggtgctcaa ccggccgggg caggacgtcg gccaggcgca gggcctgcaa cgccagctca
    12061 ctggtccggg ccacgaagtc gaccggcagg gcgccctgaa ctcgccggta cacatcgacg
    12121 aagccgtcca ggggaacgtt ccagctcgtc cggggcggcc gggacagctg cacgatgccc
    12181 agcccgacca gatgctggag gaagccacgc agcacgtccc cggcatcggg ggccaggcgg
    12241 cgcacgagct cgtcgacatc gtgcacgccg tcggccagga cgttgcggat ggcgtccagc
    12301 agcggggtcc gccgcacctc caccacgcgg gtcgtggacc agcagcgcag ccggtcgccg
    12361 tcgacccagg tcagcccgtt catggtgata gtgccgtcgg ccagggtcgc ctgtcttcgg
    12421 tcggcgttga cgttgctgac ccactgcgcc gagcactccc cgaccaccgg ccatgacgcc
    12481 gtctcggcaa cctcgacccg gccgacgtgg gccagccagc cgcgcggggt gggcttcgcc
    12541 gtgccgcggg cgatcatccg cagcaggtac tccgaccgtt gccgcaaacg cttgccaccc
    12601 cagtcctcgc cggcgtcgag ccggcggccc acgtcggcga ccagctccgg cacggcccgc
    12661 gcgacggtct cgtcgaccag ccgccaaggc agccctcgta gccgctcacg ctcccgttcg
    12721 atgtcctcgt ccaacgccgc ccgccgcagc ccgagcgccg tcgaccaggc ggtggcccgg
    12781 gccagctccg gcagcgcgct gcacaccggg cgaccgttgt gcaggtcgcg gcgcagcacc
    12841 agcagctcgg cccgatcctc ggcggccggg atcagcgcgc cgacccagtc ggccagcgac
    12901 cgggcgtagg cggcgtaggc ctcctcctcg gccagcagtt cccgcaggtc ggtgaccaga
    12961 tccgggttgc cggcggcggt ccacaggcgt atcggcagcc cggccacccg cagcagcgca
    13021 ctcggtgttc gcgttcgcgg acgctctgcg ttgaatgatt cgctcgcaag ctcgctcatg
    13081 ccagcgcttc cgtgatcagg gcctgccggg ccgagctcag ccgggcccgg ttccagtgga
    13141 agaccacgta gtacgccgca acctcggccg ggtcgacgcc ggcccgctcg accgccaccc
    13201 gccagctgcg cgccgccggc gcggccgtcg accgggtcgt ctcccagaca ccgcgcagct
    13261 cggtgcaggc aatggcgacc gagtcgtccc ggagcgacac ccgccgcccg caggtgtccc
    13321 gcacgtgcgg ccaggcctgg cagcacaggc cgagcccgcc gaacaccgag cgcagctgtc
    13381 gcatcgacac cagccacgcc ggcagctccg gccgcgcgtg atgatcgagc caggccacgg
    13441 aatcagctgt gaacaggcgg tgcacgtgcg gcatcgccgc cggcccgccg aacaggaccg
    13501 cctcgggttc gtagacgccg ggcacgatcc cgtcgatcag accctgctcg cgccagcgcc
    13561 gggccagccg gttggcctcg gcccgcaccc acggctccag gccgggcgcg gcggcgaacc
    13621 ggacccgcag gccgggcgcc ttgtgcatga agaagaagtc ggtgatccgg tcggccgcga
    13681 gcatctctcg caccgccgcc gccagttccc cgtagattcc cggtttcggc cgggacaggc
    13741 ccagctgcgt ccacgtcggc gcggccccgt cgcgcagcgc ggccaggccg ccggacagga
    13801 aggtgagacg ttcttgctgt gacagcacgg tttccacctc cgcccgggtc gcttcccctt
    13861 cgacgttagg cgaagttggc gggttgtcca cgggtggtca gtcgaaggtg tgaacggcgc
    13921 taacctgtcg cacatggtta ccggacaacc ttgggagtgg ccggaaacgg tctggcggcg
    13981 ggaaacgggc cgggtgcgcg cgggccgcag cctgcggccg tcgagctggc cggacgggcg
    14041 gcaggcggcc gtggcgctgt ccttcgactc cgaccacgag acgattcccc tgcgggacgc
    14101 ggagttcagc ccgtgccagc tgtcgcaggg cgagtacggc agccgcgtcg gcgtgccgaa
    14161 aatcctgaac ctgctggcgc ggcacgggat cccggcgacg tttttcgtgc cggcggtgtc
    14221 cgcgctgctg catccggccg acatcgacgc gtacgttcga gcggggcacg aagtggccct
    14281 gcacggctgg atccacgagc gcaacacggc cctgccgccc ggtgtggaac gggacttggc
    14341 tttgcgggcc gccgacacgt tggagcgact tgccggcacg cggccggtcg ggctgcggac
    14401 cccgtcgtgg gacttcagcg ccgacaccct ggccgtgatc cgggagctgg gcctgcgcta
    14461 cgactcgtca ctgatggccg acgacgaccc gtacgaggtg gtggccgacg gcgagccgac
    14521 cgggctggtg gagatcccgg tggagtggat ccgggacgac gcgccgttct tcccgcgtga
    14581 tccgacccgg ccgagcgtgc cgccccgcca ggtgctgacc acctggcggg acgagttcga
    14641 cgccgcctac gccgacggcg ggctgttcca gctcacgatg cacccgcacg tgatcgggca
    14701 ccggtcccgg ttcgtggcgc tgcgccagct ggtcgagtac atcgccgggc acaacgtgtg
    14761 gttcgcgtca cacgctgacg ttgccggctg gtgcctgcgc gagtgaggcc gcggcggcct
    14821 tggcgctgcg ggtccagtcc cgccagccct tgatcaccag ggccgtgaac acgatgtaga
    14881 cgctggcgct gaagtacagg ccggacgcga tctgcagcgg cacgccgatc gcgtccacca
    14941 gcagccagac cagccagaac tcgaccaggc gcaggccctg ggcggcgtag gcgacggcgg
    15001 tgccgatgaa gatcgccgcg tccggccacg gggcccagga cccgttggtg gcctgcagca
    15061 gcagcgccat gccgatggtg ccgaggacca gcgccgcggc gagggcgccc agctcgggcc
    15121 aggtggagcg gcggaccagc acgccgtact cggcgtcacg gcggcgggtc cacgcccacc
    15181 agccgtacag cgagatggcg aacacgatga cctgccgcag cgcgagtccg cccaggtggg
    15241 ccgaggtgta gacggagaac agcaggaccg cggcggcgat ctgcaccggc catgtccaca
    15301 gggtgcggcg ctgggccagg aacaccacgg ccaccgcgcc gatctgaccc aacagctccg
    15361 cgaacgagat gtgctcgccc agcagcgtca gcccgtgctc cagcaaccag ttcaccctgg
    15421 tcagccccct tctccggctc ggttccgggg ctgtttcgcg cgcacgccga tggcggacgt
    15481 gtgcgcgcct ctcatccgga ctgtcaccgt cggccctgga gtcgcaccag gtcggccgct
    15541 cggcatcgct gccttgcggt tcgcgggctg taccgccggt ttggaatttc accaagcccc
    15601 ggagcgcacg tctcctgact ggagaacata agccccgggg ccggttattc cggagggatt
    15661 taggtcactc gggccgcgac tgctggtccg ggtcgggccg ggggaagccc tgcgccggcg
    15721 tgggagtgtc ggaccccggc ggctggttgc gttcccacgg cgcgtcctgg gccgacccgt
    15781 cggccggacg gctggccgcc tcggcctggg cccgggtcag ccactgctcc cagcgggact
    15841 gcatcgggcg gaccatgccg ccacccacac ccaccaccag gatgccgccg accgtggcca
    15901 acgcgaagat cagcaccggc tcggtgaccg tggtcgcgat gcccaactgg ttcagcgccg
    15961 cgatgacacc cagcgccagc aggaaggcgt agctgacggt gccgagcagc tgtccgtact
    16021 gccggccggc cagcgcaccc gtgatcaggg tgcgcaccac ccgggcgatc gccgaggcga
    16081 tcagcaccag gatgatcgcc accaccaccc gtggcaggta cgcgatgacc tggttgagca
    16141 ggtcgctgac cgggttgccg gtgccgaaca cgccgaacgc gtagttcagc gcgatcagca
    16201 tgacgaagta gaagaccagt tggacgatca gcttgcccgc gtccaccggt gatttcggcc
    16261 cgcccagccc cgaccgctcg accagccggc cgaagccgac cttgccgagc agcagctcga
    16321 ccgccttgga cagcgccttg gccaccagcc atccgaccag cagcacgatg agaaagccca
    16381 gcagcttggg cacgaacgtg gtgatcagcg cccacgcgtc gcccagcccc tgactgagtt
    16441 gatcgcccat tgccgaatgg tttcgcagcg tccaccgtgg agcaactcga cacggttggc
    16501 acgaaagggg gaaccgcgtg gcgcctggcc ccactttgat ccacagtgga cacaccggtg
    16561 gggaccgggg agacggaggc cgcccggcgc caagcgcccg gcggcctccg gcatgtcaac
    16621 gccccgagcc caccaccagg aaagaccagc gccgccgaca caagacacag gcccgccggc
    16681 gccagttgga aacgcgagtc ccgctctcgg gcaggcgagt cccgtcctcg ggccccacca
    16741 cttcacacaa ccacgctgga aatggcccga gggcgggact cgctgtaaca cgtgagcagg
    16801 actcgcgcta tcggcaacca ccccaccacg acgagacccc gcccccagaa ccggtagttc
    16861 agttgcccga gagcgggact cgcgatcaga acggggctag ggcggagagg tagttgtgca
    16921 cggactggcc gagggtggcg gagcgggcgg gcagggtgtc ggcggggacg tcggggcggg
    16981 gcgagccggg gcagaccgac gagctgtcgg gcaggacgcc gtcgacgaag tagcggttga
    17041 tcttctcggt ggcgcagggg ttggtgccgt actggccgtg ggcgccctcg tcggagacgg
    17101 tgatgagatt gtcccgaagg cgttgcgcca tggcgggtcc gccggcgtac tcggtctggg
    17161 tgtcgccctc tccctgcacg acaaccccga cgggatagcc cctgcgggcc agggaaaccg
    17221 gcggctcggc gggagtgaag gagcggtagg tgcaggtggt cggagccgcc cgcagcacac
    17281 cgtagccgta cgggaaggcg tcccgataga tgcgcatgtc ctggtagtag gtggtcacgt
    17341 cagttggcca gtcggcctcg caggtgacgg tgtcgaaaac accggactgc aaggcgtcca
    17401 ggccccgctg ggccagtgcg gtgccggcgc cgacggcgtc gccgacggcg acatggtcgc
    17461 ccttgcgcag ggacaccagc acctgggcca ggtccgacca cagtggacgg tagcgggcgc
    17521 cctcgccgac ggccccgtcg agggtgctgc gggtgaactt gccgaccggg gacttggcca
    17581 gggtgctggc caactgttcg acggagacca gcacggcggc ccgcccgacg ccgaggccga
    17641 aggccccgtt gcggtccccg acccacgcgg cccaagagtc cacatcggac cgataggcgg
    17701 cggcctgctc catgaactgc cgacgccaga tccactcggg gtgcacggac gagtccagca
    17761 cggacaggtt cagccgatcg gggaacagac tcccgtagac ggccccgaga taggtgccgt
    17821 acgagtagcc gaggtagttg atcttggcga ctcccagcgc gtcgcggatc tggtccatgt
    17881 cccgggcggt gtcccgggtg tcgatgaacg gccggatgcc gccgccggag cgcttgcagg
    17941 cgtcctcggt cgagcgggcg tcggcggccc acgccgcgaa ctggtcgtcg gcgggccggg
    18001 actccaggcc ggcgagacca cgcggggtca ggcagcgcag ggcggtggac gagccgacac
    18061 cgcgggggtc gaagccgacg aggtcgtagt actggccgag cggcgtgtgg tcggcgatgt
    18121 agcgcggcat ggacagcccg ctgccgccgg gcccgccggg gttgatcagc agcactccct
    18181 tgcggtgcgc gggatcggcg gccgggcgcc ggctcaccat gacggctatg gtgccctggt
    18241 cggggtgcac gtagtccagc ggcacggaca gcgtggcgca ttcgagtgcg gcgagcgcgc
    18301 cggagcacgg gccccagacc acccgctgcg cctgcgccgg agtcaccagc gacacgacag
    18361 cgagcaggct cagcgcgacg ggcagcagtc ttcgcaagtc aacctcctcc atggctttca
    18421 accccgaaca taggggcgat ttcggtccgc gagctggttg ttcagtcgac cgggtgggtg
    18481 gcgtgcaaag ctgtggcaat gggtgatctg gcgtgggact cgttgtcgac ggagacgttg
    18541 cgccggctcg agcacgcctc gggccggctg gccaccggca cgatcggcga gatggagcgg
    18601 cggctgccgt ggttccggcg actgccggcc gaccagcggg ccagcgtgct gatggtcacc
    18661 cagtccgggg tcgccggctt cgtgtcgtgg ctgcgcgaca acaagcaggc gatccggctg
    18721 accgccgagg cgttccgctc cgcccccaag gacatgtcgc gctgggtgag cctgcgccag
    18781 accgtggaac tggtccgggt ggcgctggag gtcttcgagc agatgctgcc ggacatcgcc
    18841 gccgacgaga aggagcgcgg ccagctgacc gaggcggtgc tgcgctacgg ccgggagatc
    18901 gccttcgccg ccgccacttc ctatgcggcg gccgccgagg cccgtggcgc gtgggacgcc
    18961 cggctggagg cgttgatcgt ggacggcatc gtccgtggcg acgccgagga gtccctgctg
    19021 tcccgggcgt cggcgctggg ctggcagcag gcggccgagg ccacggtcct ggtcggcaac
    19081 ccgatgtcgg ccgagccgac ccgggtggtg ttcgacgtgc gcagccgggc cgcccggatc
    19141 caccggccgg tgctgctcag cgtgcaggga tcacggctgg tggtggtgct gggcggctcc
    19201 gaggacgagg cccggggcca ggaggtgctg gccaagatgg ccgaggcgtt cggccccggc
    19261 ccggtggtcg tcgggccgac ggtggacagc atcgccgagg cgcaccgcag cgcctccgac
    19321 gccctgtccg gcctgcgggc ggtggtcggc tggccgaccg cgccgcggcc ggtgcggtcg
    19381 ctggacctgc tgccggagcg ggcgctggcc ggcgacccgg aggcggagtg gcagctgatc
    19441 gagcgcatcg cccggccgct ggaggaggcc accggcgggc tgatggccac agtggacgcg
    19501 ttcctggaga ccggcggcgt gctggaggcg tgcgcccgca acctgttcgt gcacccgaac
    19561 acggtccggt accggctcaa gcgggtcacg gagctcaccg gccgcaacgc caacgacccg
    19621 cgcgacgccc tggtgctgcg ggtggcgctg accgtgggcc ggctggccaa ggcccgcggc
    19681 ctgtggtgac agtgagcgac gcctcagggg ctgggatgcg acgccttcga caaccctcca
    19741 ggccgctcac tggacatttt ctagcaacct ttggagggtt cctacaacgc tgaccatcgg
    19801 acttcgtcgg tggcgacatc ccgggacgcc gccgcgaccg tgttcagtga tctggtgatc
    19861 gcgctgctcg ctcccggaca gggatctcag gcccccggca tgctcgcccc atggctcgaa
    19921 ctggacggcg tcgcggagct cgtggccggt tggtccgaga ccaccggcct cgacctggcc
    19981 cggctgggca gcacggcgga cgccgaggag atcaaggaca ccgccatcac gcagccgctg
    20041 atcgtggcgc tgaccctggt ggccttccgc gagctccagc ggcgggtgcc ggtgccggcg
    20101 gccgcgccgg tggccggtca ctccatcggc gagctggccg cgtcggcgat cgccggcgtg
    20161 ctgtccatgg acgacgccgt ggcgctggcc gcggtgcgcg gccgcgcgat ggccgaggcc
    20221 tgcgccctgg agccgaccgg catggccgcg gtgatgggcg gcgaggccga cgagctgctg
    20281 gcccggctgg acgagtacgg cctggtcccg gccaaccgca acggcgccgg ccagaccatc
    20341 gccgccggct cgttgaccgc gctgcagaag ctggccgacg agcggccggc cggcaccaag
    20401 gtggtgatgt tgaaggtggc gggcgccttc cacacccact acatggaccc ggcccgggag
    20461 acgctgcggg agaaggtggc cggcgtggcc accgccgacc cgaaccggcc gctgctgtcc
    20521 aacgcggacg gctccgtggt caccagcggc tccgagatgc tcggccgcct ggtcgcccag
    20581 gtgaccctgc cggtgcgctg ggacctgtgc atggacacgc tggcccgctc cggcgtgacg
    20641 accaccatcg aactggcccc gggcggcgcg ctgaccggcc tggtcaagcg gcagctcaag
    20701 gacgtcgtga ccaagccgat cgcgatcaag accccggcgg acctggacaa ggcagtggag
    20761 gcggtgcagc agtgagcgag cgtcccagtc tgatcggccg caccggcccg gccggcaccc
    20821 ggctgttggg cttcggcagc gcccagggca accgggtcgt caccaacgac gacatcgcgg
    20881 cgatgggcgt ggacaccaac gacgagtgga tccggcagcg ggtcggcatc gtcgagcggc
    20941 ggttgtgcga cccggaccag acgctggtcg acctggccgt ggccgccggc gccaacgcgc
    21001 tggccgactc gggcgtggcg gccggcgaga tcgacaccgt gctggtggcg acctgcacca
    21061 tgccgggcaa catccccaac gcggccgcgc agaccgcgga ccggatcggc gtcagctcgc
    21121 cggccgcctt cgacctgaac gccgcgtgcg ccggcttccc gtactcgctg accgtggcca
    21181 gcgacatgat ccggggcggc agcgcgaaca aggtcttggt gatcggggcc gagcggttca
    21241 ccgactgggt ggactggtcc gaccgcggca actgcatcat cttcgccgac ggcgcgggag
    21301 cctgtgtggt cgggccggcc gacgagccgc tgatcgcgcc ggccgtgctg ggcagctccg
    21361 gcgacctggt ggacatgatc ggcctgaccc cggccggcca catcttccag gagggccagt
    21421 cggtgttccg ctgggccacc acccagatcg cgccgatcgc cgagcgcgcg gtggaggcgg
    21481 ccggcgtgaa gctgtccgac atcgacgtgc tggtgccgca ccaggccaac ctgcgcatcg
    21541 tcgagcacat cgccaagaag ctgcgggcca agggcgcccg cgacgacatg gtggtggccg
    21601 acgacatcgt gcactccggc aacacctcgt ccgcctcgat cccgatggcc atcgaccaca
    21661 tgcgggccga cggccggatc tccagcggcg acgtgatgct gctggtcggc ttcggcgccg
    21721 gcctgtccta ctcgggccag gtcgccatct gcccctgacg ggcacagctt tccggtgcgg
    21781 cgacccgccc cgccggggaa tcacgatgaa aggaaccaca aggtggacaa cgaggagatc
    21841 cgcaccgggc tggccgagat cgtcgaggag gtcgcgggtg tggccgtcga cgacgtgacg
    21901 gtcgagaagt ccttcgtcga cgacctggac atcgactcgc tgtccatggt ggagatcgcg
    21961 gtgcaggccg aggacaagtt cggcgtgaag atcccggacg acgagctggc caacctgaag
    22021 acggtcggcg acgcggtgaa ctacatcgcc agcaacgcct gagcttgtcg ggaacgaact
    22081 gcagtagagc ggaggcgaag tgagctctgt cgacgtcgtc gtcaccggtg tcggcgcgac
    22141 gaccccactg ggcggggacg tcgcgtccac ctgggacggc ctgctcgccg gccgcagcgg
    22201 ggtatcgacc ctggacgcgg actgggtgca caagtacgag ctgccggtgc agatcgccgc
    22261 gcagctcaag gttcagccca ccgagatcct gcccagggtt gaggcccggc ggctggaccg
    22321 cagcgagcag gtcgccatgg tggcgtcccg gcaggcttac tccgacgccg gcctcgacga
    22381 ggacgccgtc gacccggagc ggctcgcggt gatcatcggc accggcatcg gcggcgcgct
    22441 gaccctgctc gcgcaggacg acctgctgga gacggcgggc ctgcgcaagg tgtcgccgct
    22501 gaccgtgccg atgctgatgc ccaacggccc ggccgcgcac gtcggcctga cgctcaaggc
    22561 ccgggccggg gtgcacgccc cggtgtcggc ctgcgcgtcc ggcgcggagg cgatcgcctg
    22621 ggcctaccgg atgatccgca gcggcgaggc cgacgtggtg gtggccggcg gcgccgaggc
    22681 gtgcatcacc ggcatcacga tggccggctt cgcgcaggcc cggaccatgt ccacccgcaa
    22741 cagcgcgccg gagcaggcct cccggccgtt cgacgtggag cgggacgggt tcgtgctcgg
    22801 cgagggcgcc ggcatcatgg tgctggagcg ggccgaccac gccaaggccc gcggggccaa
    22861 ggtgtacggc cggctggccg gcatcggcac cagctccgac gcgtaccaca tcaccgggcc
    22921 cgacccggag ggcaacggcc agctgcgcgc catcaaggcg gccatgcgca gcggggagct
    22981 ggcggccgag gacatcgggc acgtgaactg ccacgccacc tcgacgccgg tcggcgacac
    23041 gatcgagtcg atcgccatcc accgggcgat cggcgaccat ccgctgctga ccgcgccgaa
    23101 ggggtcgttg ggccacctgc tgggggcgtc cggcgcggtg gaggccatcg cgaccgtgct
    23161 gtccatccgc gacggcgtca tcccgccgac cgcgaacctg cagacgccgg atccggcgct
    23221 gctgcacgag gtggtggccg gcgagccgcg tcgggtggag ctcaaggccg cgatcaacga
    23281 ctcgttcggc ttcggcggcc acaacgtggc cctcgccttc gccaaggtct gacgtttgcg
    23341 ccgggagggg ggctttcctg cgttggatgc aggtaaagcc cccttcccag cttttcttgg
    23401 tgctcagaag ggggcattcc tggcgttgaa cgccaggaat gcccccttcc gggcttgttc
    23461 gggacgtcag gccgggcgga tctcgtccca ggccacgggc agcgccgcgg ggccgtagac
    23521 agtggtgtcg gccttgaact ggatctcggc cagcgaggtg gccagccgca gggtcggcac
    23581 ccggcgcggc agggtggcca gcgcggtggt cagctccagt cgggcgatct gctggccggc
    23641 gcactggtgc gggccgtggc cgaagccgat gtggccgctg gtggcccggt cgatgtccag
    23701 ccgctccggc tcggcgaagc gctccgggtc gtggttggcc gcctggatgg ccaccaccac
    23761 gtagtcgccg gcggcgatcg gcacgccgcc gatctcagtg tcctcggtgg ccacccgcat
    23821 cagcccgg
//
