LOCUS       NZ_CP073318            20720 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4275724
            Orig. end                         :: 4296444
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20720
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="CDPS"
                     /region_number="28"
                     /rules="CDPS"
                     /tool="antismash"
     cand_cluster    1..20720
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="CDPS"
                     /kind="single"
                     /product="CDPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20720
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[10000:10720](+)"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10720
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="5000"
                     /detection_rule="CDPS"
                     /neighbourhood="10000"
                     /product="CDPS"
                     /protocluster_number="1"
     gene            278..1147
                     /locus_tag="JJ691_RS18240"
                     /old_locus_tag="JJ691_36390"
     CDS             278..1147
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020665947.1"
                     /locus_tag="JJ691_RS18240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36390"
                     /product="NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_211769945.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 1.1e-07, bitscore:
                     30.5, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARVFLAGATGALGRRLVPLLLAHGHHVTGLARSTASADRIRELG
                     AEPAAGDALDADSLRAAVAAARPDVVMHQLTDLASRDLAANSAIRVVGTRNLVEAALAA
                     DVRRFVVQSIAFAYEPGTAPASEDTPLDFTAPEPRQTTVRGIAELETQAARVESHVVLR
                     YGTFYGPGTWYSPTGLMAEAARAGQLPANRDVTSFVHIDDAATAALRSLDWETGPVNIC
                     DDEPAPATEWVPEFCALVDAEPPAPSDQRTPFARGADNAHARGIGWRPAHPSWRISFRE
                     SRSAAHRM"
     gene            complement(1127..2587)
                     /locus_tag="JJ691_RS18245"
                     /old_locus_tag="JJ691_36400"
     CDS             complement(1127..2587)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="JJ691_RS18245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36400"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_211769946.1"
                     /transl_table=11
                     /translation="MDVPVLIVGGGPVGLFLAAELRLSGVAPLVVERLAEPDEGKNDDD
                     RGLTARTMQTLDLRGLGDPVRAMTAAALRRLAGLSEQTAGDDPGDLAELMASLGMADFK
                     GDFAMLPFIDRHGELADLAPPLMVMQGEFERLLADRVAELGVEVRRGLELVAVEDETTA
                     VFADGTRISADWLVGCDGGRSTVRRQAGFDFPGTDPSMLARTGIAAYDGDLPLAPGIHR
                     LPDGILAVAPAPSPSMTIEFDPSPFDRDSTLTAEEFQASLRRVSGHDFTVTAIEKPMRI
                     TDNARQASTYRRGRVLIAGDAAHVHSPIGGQGLNLGLQDAANLGWKLALVARGVADDEL
                     LGTYTAERHPVGAQVLRDSRAESALIRTDAQTEALRGVLAEALDARTMLELSHGLRIRY
                     GDDKNPLVGTFSADTRLLDARARYVGPDVEVVGPWEDRVAVESGSGEGTLIRPDGYLAW
                     AGTDADELRAALRRWFGTPVGNLHSVCR"
     misc_feature    complement(2519..2521)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    2577..2592
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.86"
                     /tool="antismash"
     misc_feature    2620..2638
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 23.51"
                     /tool="antismash"
     misc_feature    complement(2635..2653)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.38"
                     /tool="antismash"
     gene            2679..3122
                     /locus_tag="JJ691_RS18250"
                     /old_locus_tag="JJ691_36410"
     CDS             2679..3122
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024212.4"
                     /locus_tag="JJ691_RS18250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36410"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_211769947.1"
                     /transl_table=11
                     /translation="MDNRDRLIERIEQAEDRFLRLTSAGGASPLASTDLTMRQLQALLV
                     VSFVDGASGQDLARALGVGLAAVTGITHRLSARGLIRRAVDPDDRRVRRIYLSPKGSAM
                     LAELRDAGRNNKRRLLKRLDTEALHKMADAMDALNEAAESDHT"
     gene            complement(3502..3900)
                     /locus_tag="JJ691_RS18255"
                     /old_locus_tag="JJ691_36420"
     CDS             complement(3502..3900)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1167:
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020636798.1"
                     /locus_tag="JJ691_RS18255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36420"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_211771558.1"
                     /transl_table=11
                     /translation="MERAGRGDLFDPRCPTRQLLDRIGTKWTSMAVKVLAEAAPGEVRF
                     AELRRRMSGVSQKMLSVTLHSLVRDGLVGRRVEPTVPPRVHYRLTELGLSLEAPLAALR
                     AWAEEHMVEIDQANAVHDAQHADVLDSM"
     gene            4018..4899
                     /locus_tag="JJ691_RS18260"
                     /old_locus_tag="JJ691_36430"
     CDS             4018..4899
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (32-152). E-value: 3e-27.
                     Score: 87.7. Matches aSDomain:
                     nrpspksdomains_JJ691_RS18260_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262: haloalkane dehalogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020660092.1"
                     /locus_tag="JJ691_RS18260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36430"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_249228015.1"
                     /sec_met_domain="PF00561 (E-value: 6.5e-23, bitscore: 80.9,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 4e-15, bitscore:
                     56.2, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDTSSPRPPKVELRRIATNGVHLNVATAGAGPAVVLLHGFPHTW
                     QVWSELIGPLSAHHRVIAPDLRGFGASTRAPDGYDAGTLADDIDGILDAVAEPTAAVVA
                     IDAGTPVAVLLALRRPDRIRRLVVMEALLGSLPGAEEFLAAGPPWWFGFHAVPGLAETV
                     LIGHEEQYIDWFLTAGTRSRRVPPDIHDAIINAYTGVDALRCAFSYYRALPTTARHLSD
                     AVAGGRLTVPTLAIGAHPVGAALERQLRPIADDLTGHLMPDCGHIIPLDRPRELLGLVR
                     PFLAADLVAEPT"
     aSDomain        4114..4473
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS18260_Abhydrolase_1.1"
                     /evalue="3.00E-27"
                     /label="JJ691_RS18260_Abhydrolase_1.1"
                     /locus_tag="JJ691_RS18260"
                     /protein_end="152"
                     /protein_start="32"
                     /score="87.7"
                     /tool="antismash"
                     /translation="PAVVLLHGFPHTWQVWSELIGPLSAHHRVIAPDLRGFGASTRAPD
                     GYDAGTLADDIDGILDAVAEPTAAVVAIDAGTPVAVLLALRRPDRIRRLVVMEALLGSL
                     PGAEEFLAAGPPWWFG"
     gene            5281..6114
                     /locus_tag="JJ691_RS18265"
                     /old_locus_tag="JJ691_36440"
     CDS             5281..6114
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (2-168). E-value: 5.5e-16. Score:
                     50.9. Matches aSDomain:
                     nrpspksdomains_JJ691_RS18265_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004824.0"
                     /locus_tag="JJ691_RS18265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36440"
                     /product="oxidoreductase"
                     /protein_id="WP_211769949.1"
                     /sec_met_domain="adh_short (E-value: 2.2e-33, bitscore:
                     114.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTWFITGGTPGGFGMAYANAALAIGDRVALTARRPDELAEWAQQ
                     HGDRVLVLPLDVTDREQIRRAVRAAEERFGGIDVLVNNAGRGWYGSVEGSTDDTVRRTF
                     DLNFFGAVDVIRAVLPGMRERGSGWIVSMSSLAGLVGITGFGYYSAAKFALEGLTEALR
                     REVEPFGVKVLSVEPGAFRTNAYAGFDDEPISETVDAYHPLLTEVRAAFVAENGKQAGD
                     PDRGVRAVIEAMNSANPPERLVLGNAAFESATTKFEATLTELRVHEKLSRGADFD"
     misc_feature    complement(5282..5296)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.8"
                     /tool="antismash"
     aSDomain        5287..5784
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS18265_PKS_KR.1"
                     /evalue="5.50E-16"
                     /label="JJ691_RS18265_PKS_KR.1"
                     /locus_tag="JJ691_RS18265"
                     /protein_end="168"
                     /protein_start="2"
                     /score="50.9"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TWFITGGTPGGFGMAYANAALAIGDRVALTARRPDELAEWAQQHG
                     DRVLVLPLDVTDREQIRRAVRAAEERFGGIDVLVNNAGRGWYGSVEGSTDDTVRRTFDL
                     NFFGAVDVIRAVLPGMRERGSGWIVSMSSLAGLVGITGFGYYSAAKFALEGLTEALRRE
                     VEP"
     CDS_motif       5665..5733
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS18265_0001"
                     /evalue="1.60E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="JJ691_RS18265"
                     /protein_end="151"
                     /protein_start="128"
                     /score="14.2"
                     /tool="antismash"
                     /translation="WIVSMSSLAGLVGITGFGYYSAA"
     gene            6141..6272
                     /locus_tag="JJ691_RS52935"
                     /old_locus_tag="JJ691_36450"
     CDS             6141..6272
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS52935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_36450"
                     /product="hypothetical protein"
                     /protein_id="WP_256449400.1"
                     /transl_table=11
                     /translation="MHTLVREIAPFRLITMDDVAAFLLRNGGMNGHDLNIDGGWLLT"
     gene            complement(6279..7382)
                     /locus_tag="JJ691_RS18270"
                     /old_locus_tag="JJ691_36460"
     CDS             complement(6279..7382)
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1087: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015802584.1"
                     /locus_tag="JJ691_RS18270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36460"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_211769950.1"
                     /transl_table=11
                     /translation="MKISIVGGGLGGLTLARVLHVNGVQSTVYELDASPTARDQGGTLD
                     MHEESGQRALREAGLFDQFRAVARDEGEAMRLMDGRGTVYIDDVAPEPGGRPEVDRKEL
                     KRILVESLPAGTVRWGAKVTSVTPSTITVGGETVESDLVVGADGAWSKVRPLLSDARPI
                     YSGLSFVEIHLSDVDAKHPDAAAFVGPGSMFALDHGKGVMAQRNGDGRIRVYLAIRAED
                     ENWAGTELVDPADPVQTRLRLLELFDDFAEPLRGLIADADATFVPRAIHALPVGHRWTR
                     VPGVTLLGDAAHLMSPFAGEGANLAMLDGTDLALALAAGSDVETALTAYETAMFPRAEE
                     AAHDSATNLVECFEPGGAQRLAGVMAG"
     misc_feature    complement(7368..7383)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 19.84"
                     /tool="antismash"
     gene            complement(7396..8061)
                     /locus_tag="JJ691_RS18275"
                     /old_locus_tag="JJ691_36470"
     CDS             complement(7396..8061)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635272.1"
                     /locus_tag="JJ691_RS18275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36470"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_211769951.1"
                     /transl_table=11
                     /translation="MYNRRERPAKPALTRDGIVGTALAVMRAEGMDKVTMRRLAKELDT
                     GPASLYVYVRDTEELHAAMLDELLGEVDLDPGRSPDWRERLHKVITSYQRVLHENPSLA
                     RVAMVTRLSGPNYLAVVEAVLGRLAEGGMPKAQAAWAVDMLLLIATASAVEHGTQQENL
                     AAAVANHDRLERVVADAPADTYPNIAAHSRELMAGPAVNRARWMFDVLISGALGTPIP"
     gene            complement(8103..8747)
                     /locus_tag="JJ691_RS18280"
                     /old_locus_tag="JJ691_36480"
     CDS             complement(8103..8747)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (3-200). E-value: 2.2e-08.
                     Score: 26.0. Matches aSDomain:
                     nrpspksdomains_JJ691_RS18280_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226954.1"
                     /locus_tag="JJ691_RS18280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36480"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_211769952.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-09, bitscore:
                     38.3, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.9e-05, bitscore: 23.7,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTLMVLHGGPGRRSVQPIVDRFEPTHRVLAPTHAGWDGTSRPD
                     WYEGPDDLAMEYLDLLDDENIEDLVVIATSFGGWIAAEMVIRDRGRRIGGLVLIDVIGP
                     RIPGLPVATPNPDQAAQLPPAVRDNLGVLAHYMAPHPQGDPRLPHRVARVTVPTLAIWG
                     EDDRVAPLEYGRAYVKHFPKAEFVSLPGVGHAPLMEALERTLDLIADFLRP"
     aSDomain        complement(8148..8738)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS18280_Abhydrolase_1.1"
                     /evalue="2.20E-08"
                     /label="JJ691_RS18280_Abhydrolase_1.1"
                     /locus_tag="JJ691_RS18280"
                     /protein_end="200"
                     /protein_start="3"
                     /score="26.0"
                     /tool="antismash"
                     /translation="TLMVLHGGPGRRSVQPIVDRFEPTHRVLAPTHAGWDGTSRPDWYE
                     GPDDLAMEYLDLLDDENIEDLVVIATSFGGWIAAEMVIRDRGRRIGGLVLIDVIGPRIP
                     GLPVATPNPDQAAQLPPAVRDNLGVLAHYMAPHPQGDPRLPHRVARVTVPTLAIWGEDD
                     RVAPLEYGRAYVKHFPKAEFVSLPGVGHAPLMEA"
     CDS_motif       complement(8493..8525)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS18280_0001"
                     /evalue="2.70E-03"
                     /label="NRPS-te1"
                     /locus_tag="JJ691_RS18280"
                     /protein_end="85"
                     /protein_start="74"
                     /score="10.4"
                     /tool="antismash"
                     /translation="SFGGWIAAEMV"
     gene            8910..9431
                     /gene="msrA"
                     /locus_tag="JJ691_RS18285"
                     /old_locus_tag="JJ691_36490"
     CDS             8910..9431
                     /EC_number="1.8.4.11"
                     /GO_function="GO:0008113 - peptide-methionine (S)-S-oxide
                     reductase activity [Evidence IEA]"
                     /GO_function="GO:0033744 -
                     L-methionine:thioredoxin-disulfide S-oxidoreductase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006979 - response to oxidative stress
                     [Evidence IEA]"
                     /GO_process="GO:0030091 - protein repair [Evidence IEA]"
                     /codon_start=1
                     /gene="msrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013227722.1"
                     /locus_tag="JJ691_RS18285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36490"
                     /product="peptide-methionine (S)-S-oxide reductase MsrA"
                     /protein_id="WP_211769953.1"
                     /transl_table=11
                     /translation="MSNTTETAVLAGGCFWGMQDLIRRQPGVLSTRVGYSGGDTPNATY
                     RNHGTHAEAVEIVFDPSVTSFRDLLEFFFQVHDPSTKNRQGNDIGLSYRSAIFYTSDEQ
                     RRVAEDTIADVDASGLWPGKVVTEVQAAGPFWEAEPEHQDYLLRYPNGYTCHFVRPGWK
                     LPKRAESTQG"
     gene            complement(9461..9679)
                     /locus_tag="JJ691_RS18290"
                     /old_locus_tag="JJ691_36500"
     CDS             complement(9461..9679)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS18290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_36500"
                     /product="hypothetical protein"
                     /protein_id="WP_211769954.1"
                     /transl_table=11
                     /translation="MQRRYGSRHVFFAGRSIESNVAFDQRLLDAMRFGSRGDALFSAGV
                     DRGVHYWELDPDRAGPFICQGYCPSGG"
     misc_feature    9707..9717
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    9902..9916
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.72"
                     /tool="antismash"
     gene            10001..10720
                     /locus_tag="JJ691_RS18295"
                     /old_locus_tag="JJ691_36510"
     CDS             10001..10720
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) CDPS:
                     CDPS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04539.1"
                     /locus_tag="JJ691_RS18295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36510"
                     /product="tRNA-dependent cyclodipeptide synthase"
                     /protein_id="WP_211769955.1"
                     /sec_met_domain="CDPS (E-value: 4.9e-49, bitscore: 166.2,
                     seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFTITPLAGSRADNHDHVLVGLSPQNGRYKPEYIRNLISWLHPRF
                     RSIDVVIPGFEAAYTLVAAGHPPAQAVHRARRAYRQLRNPAVQALADLGVPDAARHVMS
                     WTRLHADHAYRAALNRSRIAYMTDPGIRRACREMTAEVVANSAAGHLVTDRDIDIAVRY
                     VIAEIPLLTDGPSLFGTNGSVFVYHRATPLVAEIARSDSILSAQPGQAWAVVEQKEQNH
                     DEHGRTRSSAALPVPAR"
     misc_feature    10019..10021
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            10665..11870
                     /locus_tag="JJ691_RS18300"
                     /old_locus_tag="JJ691_36520"
     CDS             10665..11870
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="JJ691_RS18300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36520"
                     /product="cytochrome P450"
                     /protein_id="WP_211769956.1"
                     /sec_met_domain="p450 (E-value: 1.7e-19, bitscore: 69.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTAEPDLPLHYPFPLGDTGALPPLTAWAQQAKPVCPVRLPSGV
                     TAWMLTRKDDVAQALADNRFSRNLAEPGSPRMVGEDLTSVDHAIFNLDPPEHGRVRQVL
                     SSWFTRRAVQRHRPLVARHAQRLLAAMADGPNPVDLVEAYTATLPLDAMGEVMGVPPDL
                     AQECRRVYPMSLDLSSTPDAVEKETDAAKQFIAKLIKVRRAEPMPDSPVHALIEAREQG
                     LITEAEMFGTVFLIFVTSFDPLVAPLTTGPMMLMLHRAQLAECQADPALWPKAVEEILR
                     YFHNGGLGFPRVAREDVELRGTLIRAGDALVVPMQAVTWDPRHYRNPERFNIHRATDGS
                     ATFGAGPHYCLGSQLARVVLQEAISALFTRFPTLDLAVSERELPWDPNRMFTRPMQLPV
                     TW"
     gene            11879..12610
                     /locus_tag="JJ691_RS18305"
                     /old_locus_tag="JJ691_36530"
     CDS             11879..12610
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="JJ691_RS18305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36530"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_211769957.1"
                     /transl_table=11
                     /translation="MTASQFEELAYLYEHSFEVWPYRRDVEQHSVLAALGEVAGLAALD
                     LGCGAGSYTRLLAEHGARPVVGVDSAAGMVDYARRREAEDPSGATFARRDASEPISGRF
                     DVVLAVHLLPYAETVETLTAMCATARSALSGPGKMFVTVTINPGFATEPGYYTRYGFDL
                     IAPSAELRDGDPVRLRSEFLGGSIDVTPHFWSRATQEKALLNAGFREVTWWAPQCSPTA
                     DVDHFGDYLRKPPTLVVTATA"
     gene            12682..13476
                     /locus_tag="JJ691_RS18310"
                     /old_locus_tag="JJ691_36540"
     CDS             12682..13476
                     /EC_number="2.1.1.-"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009948994.1"
                     /locus_tag="JJ691_RS18310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36540"
                     /product="SAM-dependent methyltransferase"
                     /protein_id="WP_211769958.1"
                     /transl_table=11
                     /translation="MPTGLDPDVPSAARVYDYFLGGYHNLAVDREFAHRAEQTMPDLPL
                     ILRTSRRFLRRAVHYLLEQGITQFLDLGSGIPTAGNVHEIAHAAAPRSRVVYVDRDSVA
                     MAHAALMLEGNDNAAALRADLRDPREVLRHNVVTNLLDLSQPVAVLMSAVLHFVESDVE
                     AQSIVAGYRTAIAPGSYIAISQGTQEAAGERGEQVIRLYDQTDSPFTARDRGRFTRLFR
                     GLDLVEPGVVYVPQWRPESPEDVDEHPELSCAYGAIGQKPLY"
     misc_feature    13517..13532
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 20.48"
                     /tool="antismash"
     misc_feature    complement(13519..13532)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 15.92"
                     /tool="antismash"
     misc_feature    13519..13533
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 19.72"
                     /tool="antismash"
     misc_feature    13528..13548
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 21.63"
                     /tool="antismash"
     gene            13582..15603
                     /locus_tag="JJ691_RS18315"
                     /old_locus_tag="JJ691_36550"
     CDS             13582..15603
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024938.4"
                     /locus_tag="JJ691_RS18315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36550"
                     /product="acetate--CoA ligase family protein"
                     /protein_id="WP_211769959.1"
                     /transl_table=11
                     /translation="MHGLGVFRDPASVAVVGASEDRSKWGHWLAAGALTGAGRRRVHLV
                     SRRGGTVCGQPCATNLRSLDEVPELVVLCVPATHVPEVVTEGLSLGVKGFLGITAGVSD
                     ELELARRIRSGGARLVGANSLGIVDTATELCLAWGSFTAGPLAIVSQSGQVGSELALLG
                     ERHGLGISRFVSLGNAADVTATELLADLADHSATEVVAVYLENFTDGSLLLRALRGLRE
                     VGKPTLLLTVGGSAASTRLARSHTGSLTSPLDVVDAACRAAGVARVSTPSELIDVARAL
                     LAARPPHGDRVAIIGDSGGQCGIAADVAHTNRLTVPAFSHDIGVALPAGSAAHNPVDLA
                     GAGEQDIANYARITEAVLRRDDVDAAVLTGYFGRYGLDIPAIGGREVAVAQRIGAAVAD
                     AGKPVVVHSMGPDSATAHALWAVGVPTYDRIEAALSALRGLVAFGRPPELPLPYQARPL
                     DALPEGYWETRQVLVDVAFPRGLVVRARAELARAARLTAPYVLKAAWLEHKSEAGGVRI
                     GLATVDQLTAAYDEMSARLGPGDYVVEEQDIRPDTVEILIGARRDPDFGPLVVVGAGGT
                     ETELRQDIATELAPVSPATARDMLGRLHCAPLLRGWRGRPAVDIGGLADLVHRMSLLVA
                     ASPLVGELELNPVRVGPDGPLAVDALIFPVARQEARHA"
     gene            15600..16754
                     /locus_tag="JJ691_RS18320"
                     /old_locus_tag="JJ691_36560"
     CDS             15600..16754
                     /GO_function="GO:0016627 - oxidoreductase activity, acting
                     on the CH-CH group of donors [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006: acyl-CoA dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012656.4"
                     /locus_tag="JJ691_RS18320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36560"
                     /product="acyl-CoA dehydrogenase family protein"
                     /protein_id="WP_211769960.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 6.3e-25, bitscore:
                     87.3, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 1.2e-25, bitscore:
                     88.8, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 5.8e-47, bitscore:
                     158.9, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTHFPAWPLSAEQRQIVNLCRDFAEREIRPRAREVDEADVVTPV
                     DLFARAGEVGITNFMLPEEYGGGGFTDVFTQCLVQEELCWGDPGIGNLLCSNGFYADPI
                     LELGTGEQKKQWLTPLAGPDAPMTALATTEPNAGSDAASMITTARRVEGGYELTGQKTW
                     ISNAGTAKYYVVFAKTDRSKRSAGVTAFLLERDAPGLRFGEPMRKMGQRAIVCREVFFD
                     NVFVPASDRLGDEGRGFHGLMGTFDISRVVLGAAAVGAARAAYEFALDYARERKQFGVP
                     IIEHQAVAFRLADMATRIESARLLVHHAARQIDAGQRVTGLAAMAKLTASETAMFVTWA
                     AVQTLGGWGYSREFPVEQWMRDVKLEEIEEGTSDIMRLVISRHL"
     gene            16807..17400
                     /locus_tag="JJ691_RS18325"
                     /old_locus_tag="JJ691_36570"
     CDS             16807..17400
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025343.4"
                     /locus_tag="JJ691_RS18325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36570"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_211769961.1"
                     /transl_table=11
                     /translation="MPRPSVEAERKAQILRATCAVIADAGIHDLRLTDVARRAGVSSGT
                     IHYYFDSKQALLHAAFEHNFRHSLERRAAVLACGGSPLDLLARLVESYAPLDAESVAAW
                     RVWAELWVHGLRQPELQELNESIYGEWRRTVVGLVRDAQDQGLLKGGDPVLVANTVVAM
                     IDGLAIQVLLGSRNMTVDRMRATCRAYLDSLADG"
     gene            complement(17383..18645)
                     /locus_tag="JJ691_RS18330"
                     /old_locus_tag="JJ691_36580"
     CDS             complement(17383..18645)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.4"
                     /locus_tag="JJ691_RS18330"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36580"
                     /product="MFS transporter"
                     /protein_id="WP_256449401.1"
                     /transl_table=11
                     /translation="MRNRWPGGRAGEEDQATSSDGGLMPGSFRSLREPVFRQWFLSQLL
                     SASGGVTQGVALSWLVLQLTGSGLDLGLMSTCTFLPLFLVGPYAGALVDRIGPRRVLIV
                     TQSLMASISTLTAVLAATGVVQIWMLFAIAAATGIVSTHDATARQVYVFDLVGADGVSN
                     AVALNEVVVNGARILGPSIGGALLGFWGPAACCVFNALTFVPPLIVVLRHRVRETAHPP
                     RPQRIGGLRYAWRNPVIRACLLLAAASGMLFSLNVPVPLLATGVFHLDGTAFGLMMATF
                     GVGSLPGVLLAASGPSRPSGRRVVILAGGTGLSILATAYAPTVPLVFAAMAVTGCVSIW
                     FISLANTVVQLESDPGMRGRVNAAWSMALPGCTLVTGPFMGWVAGVAGPRLGFGVAGLA
                     MLLAAAAGWRALTRVRLTVGQ"
     misc_feature    18714..18729
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 21.92"
                     /tool="antismash"
     gene            18769..20178
                     /locus_tag="JJ691_RS18335"
                     /old_locus_tag="JJ691_36590"
     CDS             18769..20178
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012859.4"
                     /locus_tag="JJ691_RS18335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_36590"
                     /product="phosphatidylinositol-specific phospholipase C
                     domain-containing protein"
                     /protein_id="WP_211769963.1"
                     /transl_table=11
                     /translation="MRHPAVLALATPLLLLTFAGTAPAQPSSSTDAFNSLTAESHPDWM
                     AGLPAQASLAALSIPGTHDTLAIHGGLLPAFYEAQEDHGDSAATLDAQLAAGIRAIDIR
                     VRVVNNDTAFAVHHTDVYQNANFDDVLTHARNFLSAHPGETVLMDLHGECDGDSTEGGS
                     GSGSIGHCADDPSTITQADRTRIFNDYVSRYPGLFYAPTVTGASTADMPTVGQARGHIV
                     LTTFTGPRGQVYGGYGLTQLTTGDWGQYVENDWTQCDVNSKFGEAQANMAKADTATAMY
                     TTYLSANCSPFGADPEDMAKGMNPRTVDYLNSGATSHVGVVLTDFPGHALVSALIRQQS
                     GLLAGPVPSGIAGKCLDDYNSATAPGATVDLWDCNGTGAQQWTVMPDRTLRTAGLCLDV
                     TGGGTANGTHVQLWTCGGGSNQQWTSGPNGSLVSVQSGKCLDDPGASTANGSQLIIWDC
                     GAGANQRWTLP"
     misc_feature    20290..20305
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: medium, score: 22.62"
                     /tool="antismash"
ORIGIN
        1 cggcgccggc tgtcggggcc gcgactgcca ggccggcgac gagcagggtg gcgatggtca
       61 ggcatcgatg acgggcaggg atcatgaagc cgtctccgtt ccgtggttca ccaagggggg
      121 caccggtgcc accggagtgc gcgccagccc agggtagggg gccgcgaccg gggtaaccac
      181 ccgccgatag tcgtgcgcag ctcacctttt ctggtcccac ttttcgtggg aacactggac
      241 catgccggcg tggtgcgctc aggctaacgt tccggtcatg gctcgtgttt tccttgccgg
      301 cgcgaccgga gccctcggcc gtcgcctcgt tccgctgctg ctcgcccacg gacaccacgt
      361 caccggcctg gcccggtcca ccgccagcgc ggaccggatc cgcgagctgg gggccgaacc
      421 ggccgccggt gacgccctcg acgccgacag cctgcgggcg gcggtggcgg ccgcgcggcc
      481 ggacgtcgtc atgcaccagc tcaccgacct ggcctcccgt gacctcgccg ccaactcggc
      541 gatccgggtc gtcggcaccc gcaacctcgt cgaggccgcc ttggccgccg acgtgcggcg
      601 atttgtcgtg cagagcatcg ctttcgcgta cgaaccgggc actgcgccgg ccagtgagga
      661 cactccgctc gacttcaccg ccccggaacc tcggcagacc accgtgcgcg gcatcgccga
      721 gttggagacg caggccgccc gggtcgagtc gcatgtggtg ctgcgttacg gcaccttcta
      781 cgggcctggc acctggtact cccccaccgg cctgatggct gaggccgcgc gggccgggca
      841 gttgccggcc aaccgtgacg tcaccagctt cgtgcacatc gacgacgccg ccaccgccgc
      901 actacgttcc ctggactggg aaaccggccc ggtgaacatc tgcgacgacg agccggcccc
      961 ggccaccgag tgggtgccgg agttctgcgc cctggtcgac gccgaaccgc cggccccgtc
     1021 ggatcagcgc acccccttcg ctcgcggcgc cgacaacgcc catgcccgcg gcatcggctg
     1081 gcgcccagcc cacccctcct ggcgcattag cttccgcgag tcacgctcag cggcacaccg
     1141 aatgtaggtt tccgacaggc gtgccaaacc accgccgcag cgccgcccgc aactcgtcgg
     1201 cgtcggtgcc ggcccacgcg aggtagccgt cggggcggat caacgttccc tcgcccgatc
     1261 cggactcgac ggcgacgcga tcttcccacg ggccaacaac ttcgacgtcc gggccgacgt
     1321 agcgggcgcg ggcgtcgagg agccgggtgt cggcggagaa agtgccgacg agcgggtttt
     1381 tgtcgtcgcc gtaacggatg cgcaagccgt ggctcagctc cagcatggtc cgggcgtcca
     1441 gggcttcggc gagcacgccg cgcagggcct cggtctgcgc atcggtgcgg atcagcgccg
     1501 actcggcccg gctgtcgcga agcacttgcg cgccaacggg atgccgttcg gcagtgtagg
     1561 tgccgagcag ctcgtcgtcg gccacgccac gggcgacgag ggcaagtttc cagccgaggt
     1621 tggcggcgtc ctggaggccg aggttgaggc cctggccgcc gatcggcgag tgcacgtggg
     1681 cggcgtcgcc ggcgatgagc acccggccgc gacggtaggt cgaggcctgg cgggcgttgt
     1741 cggtgatccg catcggcttt tcgatcgccg tgacggtgaa gtcgtgaccg ctgacccggc
     1801 gcaggctggc ctggaactcc tcggcggtca gcgtcgagtc gcggtcgaac gggctcggat
     1861 cgaactcgat ggtcatgctc ggcgacgggg ccggggcgac ggcgagaatg ccgtcgggga
     1921 gccggtgaat gcccggtgcc aacggcagat cgccgtcgta ggcggcgatc ccggtgcggg
     1981 ccagcatgga cgggtcggtg ccggggaagt cgaagccggc ctggcggcgc accgtgctcc
     2041 gaccgccgtc gcagccgacc aaccagtcag cggatatcct tgtgccgtca gcgaaaacgg
     2101 cagtcgtctc gtcctcgacg gctaccagtt cgaggccccg gcggacctcg acgccgagct
     2161 ccgcgacccg gtcggccagc agccgttcga actcgccctg catgaccatc agcggcgggg
     2221 ccaaatcagc cagctcgccg tggcggtcga tgaacggcag catggcgaag tcgcccttga
     2281 agtcggccat gcccagactg gccatcagct ccgcgagatc accgggatcg tccccggcgg
     2341 tctgctcgct gaggccggcc aggcggcgca gggccgcagc ggtcatcgcg cgtaccggat
     2401 cacccagccc gcgcaggtcc agtgtctgca tggtgcgggc cgtgagcccg cggtcgtcat
     2461 cgttcttgcc ctcgtcaggc tcggccagcc gctccaccac cagcggagcc accccggata
     2521 accgcagctc agcggccagg aacagcccga ccggcccgcc cccgacgatc aacaccggca
     2581 cgtccatgtc accctccccg tgacgcggaa atacttcaca tgatgtgaac agtatgcatg
     2641 ccgtaaacta tcggcgccag gttttcaggg aggcgccagt ggacaacagg gatcggttga
     2701 tcgagcggat cgagcaggcc gaggatcggt tcctgcggct cacctcggcc ggcggggcca
     2761 gtccgctggc gtccaccgac ctcaccatgc ggcagttgca ggcgctgctc gtcgtgtcct
     2821 tcgtggacgg cgcctccggc caggacctgg cccgcgccct cggcgtcggc ctcgccgccg
     2881 tcaccggcat cacccaccgg ctctccgctc gcggcctcat ccgccgcgcc gtcgaccccg
     2941 acgaccgccg ggtgcgccga atctacttgt cccccaaggg atccgccatg ctcgccgagc
     3001 tccgcgacgc cggccgcaac aacaagcgcc ggctactcaa gcgcctcgac accgaggccc
     3061 tgcacaagat ggccgacgcc atggacgccc tcaacgaagc cgccgagtcc gaccacacct
     3121 gaccaccccg accccacaca ccagcgacac caaacgccac atgtggtccg tcgtcgcctt
     3181 catatgccac atagacagaa ctcatgcgcg tcatgaagat gcctgcccgt gaactctcca
     3241 aggtcgtgaa cggaatcgga catgaccggc ttcagtcgag gcgtccacga ctcgttcgct
     3301 atggaccgtc cacttactca acgtcgaacg ctcgttcgcg tcggcgttct cactcaatgc
     3361 ggcgtgagcg gatgttcggc gttcgacacc gctgcgtatc ggcgcgccgg gagtgtggtt
     3421 gggccgttcg cgtgtagtcg tcgcgacaga gggccttcgg cttggccagc agttgctggt
     3481 tcgcttgtcg cgcagctggc ttcacatgct gtcgaggaca tcggcgtgct gcgcgtcgtg
     3541 gacggcgttg gcctgatcga tctccaccat gtgctcttcc gcccaagccc gcaacgccgc
     3601 cagcggagcc tccaacgaca agcccagctc cgtgagccgg tagtgcaccc gtggcggcac
     3661 ggtcggctcc acccgacggc cgaccagccc gtcccggacc aggctgtgca gcgtcaccga
     3721 cagcatcttc tgcgacacgc cggacatccg ccgccgcaac tcggcgaacc gcacctcacc
     3781 cggggcggcc tcggcgagca ccttgaccgc catcgacgtc catttcgtgc caatgcggtc
     3841 cagcagctga cgcgtcggac accggggatc gaacagatcg ccgcgaccgg cgcgctccac
     3901 ccgcacgggc tgagtggtca ccttgacctc accacctgtc ggcaaagtgc cgtcttggca
     3961 ccacaaccac ggttacctac ggttctgtgg tcaccgatgg taaccgacgg aggcactgtg
     4021 tccgacacct cgtcaccccg cccgccgaag gtcgagctgc ggcggatcgc gaccaacggc
     4081 gtccacctca acgtggccac ggccggcgcc ggtcctgcgg tcgtgctgct gcacggcttt
     4141 ccgcacacct ggcaggtgtg gagcgagctc atcggcccgt tgtccgcgca ccaccgggtg
     4201 atcgcccccg acctgcgcgg attcggcgcc agcacgcgcg ccccggacgg ttacgacgcc
     4261 ggcactctgg ccgacgacat cgacgggatc ctcgacgccg tcgccgaacc cacggcggcc
     4321 gtggtcgcga tcgacgccgg caccccggtc gcggtcctgc tcgccctgcg ccgacccgac
     4381 cggatccgac gactggtcgt catggaagcg ctgctgggct cgctgcccgg cgctgaggag
     4441 ttcctcgccg ccggtccacc ctggtggttc ggattccatg ccgtccccgg tctcgccgaa
     4501 acggtcctca tcggacacga ggagcagtac atcgactggt tcctcaccgc cggcacccgc
     4561 agccggcgcg tgccacccga catccacgac gcgatcatca acgcctacac cggagtcgac
     4621 gccctccgct gcgccttctc ctactaccgc gcactgccca ccaccgcccg ccacctcagt
     4681 gacgccgtgg ccggtggccg gctcaccgtg cccacgctgg cgatcggcgc tcacccggtc
     4741 ggcgctgcgc tggaacgaca gctacgcccc atcgccgacg acctcaccgg acatctcatg
     4801 ccggattgcg gccacatcat tccgctggat cggccccgag aactgctcgg tctcgtgagg
     4861 cccttcctcg ccgccgacct ggtcgccgag ccaacgtgac cggctaacgc gccgtaatgg
     4921 cgcctcctcg acatgaccgc ccggcgtctg tcggcagtgc ctgacagcgg acaggggctc
     4981 cagtgacggg tgggaagaac caggacgagg tggcccagtc gcaggcgctg cgaccaatcg
     5041 gcggatccca ctctgtcatc ggcaggagag tgcattcgcc ggggctcaac ccaccggcac
     5101 gtcgtccact gaccgacgtc gttgctgcga ttaacagacg cgttccgccc gtgcatttcg
     5161 agtcggacgt tcgcaacgtt cgttgggggc agacccctgt ggaccacatg tggcgtcgac
     5221 agcgagtggg tagtggcgct acagtcatgg ctatagcagc tgtagcggag gaggctgggc
     5281 gtgaagacgt ggttcatcac cggtggcaca ccgggcggct tcggcatggc gtacgcgaac
     5341 gcggcgctgg ccatcggcga ccgggtggca ctgactgccc gtcggcccga tgaactggcg
     5401 gaatgggcgc agcagcacgg tgatcgggtg ttggtgctgc cgctcgacgt cacggaccgg
     5461 gagcagatcc ggcgggcggt gcgcgccgcc gaggagcggt tcggcggcat cgacgtgctg
     5521 gtcaacaacg cgggccgggg ctggtacggc tcggtggagg gcagcaccga cgacaccgtg
     5581 cggcggacgt tcgacctcaa cttcttcggc gcggtcgacg tgatccgcgc ggtgttgccg
     5641 ggcatgcgcg aacgtggcag cggctggatc gtgagcatgt cgtcgctggc gggcctggtg
     5701 gggatcaccg gattcggcta ctactcggcg gcgaagttcg ccctggaagg cctcaccgag
     5761 gcactgcggc gcgaggtgga accgtttggt gtcaaggtgt tgtcggtgga gccgggggcg
     5821 ttccgcacca acgcgtacgc cggcttcgac gacgagccga tcagcgagac cgtcgacgcc
     5881 taccacccgc tgctgaccga agtccgcgcg gcattcgtgg cggagaacgg aaagcaggcg
     5941 ggcgatccgg accggggcgt gcgcgcggtg atcgaggcga tgaactcggc caacccgccg
     6001 gagcggctgg tgctcggcaa cgccgccttc gagtcggcca cgaccaagtt cgaggcgacg
     6061 ctgaccgaac tgcgcgtgca cgagaagctg tcgcgcgggg ccgacttcga ctgactgccc
     6121 gatcggtcgt cgtcggcctg atgcacacgc tggtccggga gatcgccccg tttcggttga
     6181 tcaccatgga cgacgtcgcc gcgttcctgc tgcgcaacgg gggcatgaac gggcacgacc
     6241 tgaacatcga cggcggttgg ctgctgacct gagctcggtc agccggccat caccccggcg
     6301 agccgctgcg cgccaccggg ttcgaagcac tccacgaggt tggtcgccga gtcatgggcg
     6361 gcctcctcgg cacgggggaa catggcggtc tcgtacgcgg tcagcgctgt ctcgacgtca
     6421 gagccggcgg cgagggcgag ggccaggtcg gtgccgtcga gcatggccag gttcgcgccc
     6481 tcgccggcaa agggcgacat gaggtgggcg gcgtcgccga gcagggtgac gccggggacg
     6541 cgcgtccagc ggtgcccgac gggcagggcg tggatcgccc gcggcacgaa ggtggcgtcg
     6601 gcgtcggcga tgaggccgcg caggggttcg gcgaagtcgt cgaagagctc cagcagccgc
     6661 aggcgggtct ggaccgggtc ggcggggtcg acgagttcgg tgccggccca gttctcgtcc
     6721 tcggcgcgaa tggccagata gacccggatc cggccgtcgc cgttgcgctg ggccatcaca
     6781 cccttgccgt ggtcgagggc gaacatcgag ccggggccga caaaggcggc ggcgtccggg
     6841 tgcttggcgt ccacatcgga cagatggatc tcgacgaacg acagcccgga gtagatcggc
     6901 cgggcgtcgg acagcagcgg ccggaccttc gaccacgccc cgtcggcgcc gacgaccagg
     6961 tcggactcga cagtctcgcc gccgacggtg atcgtcgacg gagtcacgga cgtgaccttg
     7021 gcgccccagc gcaccgtgcc ggccggcagg gactcgacga gaatccgctt gagctccttg
     7081 cggtcgacct cgggccggcc gccgggctcg ggcgcgacgt cgtcgatgta gacggtgccc
     7141 cggccgtcca tcagccgcat cgcctcgccc tcgtcccggg cgacggcccg gaactggtcg
     7201 aacaggcccg cttcgcgcag cgcccgctgc ccggactcct catgcatgtc cagggtgccg
     7261 ccctggtcgc gggcggtcgg cgaggcgtcc agttcgtaca cagtggactg gacgccgttg
     7321 acgtgcagca cccgggcgag tgtgaggccg ccgaggccgc cgccgacgat gctgatcttc
     7381 attgcgtttc tccgatcacg gtataggggt gccgagcgcc ccgctgatca ggacgtcgaa
     7441 catccagcgc gcccgattca cggccgggcc ggccatcagt tccctggagt gtgcggcgat
     7501 gttggggtag gtgtcggccg gggcgtcggc gaccacccgt tcgagccggt cgtggttggc
     7561 caccgcggcc gccagattct cttgctgggt gccgtgttcc accgcgctgg cggtggcgat
     7621 cagcagcagc atgtccaccg cccaggcggc ctgtgccttg ggcatgccgc cctcggccag
     7681 ccggcccagc accgcctcga ccacggccag gtagttcgga ccgctgagcc gggtgaccat
     7741 cgcgacccga gccaggctcg gattctcgtg cagcacccgc tggtaggagg tgatcacctt
     7801 gtgcagccgc tcccgccagt ccggcgagcg gcccgggtcc aggtcgacct cgccgagcag
     7861 ctcgtcgagc atcgcggcgt gcagttcctc ggtgtcgcgg acgtagacat agagcgaggc
     7921 cggcccggtg tcgagctcct tggccagccg ccgcatggtg accttgtcca tgccctcggc
     7981 ccgcatcacc gccagcgccg tgccgacgat gccgtccctg gtcagcgccg gcttggccgg
     8041 ccgttcccgt cggttgtaca tgggatcgag cctaacggac gcgttcgtga cgaacacgtt
     8101 cgtcagggac gcaggaaatc ggcgatgagg tccagcgtgc gctccagggc ttccatcaac
     8161 ggggcatggc cgacacccgg cagcgacacg aactccgcct tcgggaagtg cttcacgtag
     8221 gcgcggccgt actccagcgg ggcgacccga tcgtcctcgc cccagatggc cagcgtcggc
     8281 acagtcaccc tcgccacccg atgcggcagc cgcgggtcgc cctgcggatg cggagccatg
     8341 tagtgggcca gcaccccgag gttgtcccgc accgccggcg gcagctgcgc tgcctggtcc
     8401 gggttcggcg tggccaccgg cagccccggg atccgcggcc cgatcacgtc gatcagcacc
     8461 agtcccccaa tgcgccggcc gcggtcgcgg atcaccatct cggcggcgat ccagccgccg
     8521 aaggaggtcg cgatcaccac caagtcctcg atgttctcgt cgtccagcag gtcgaggtac
     8581 tccatcgcca ggtcgtccgg cccctcgtac cagtcgggcc gagacgtgcc atcccagccg
     8641 gcgtgagtgg gcgcgagcac ccggtgcgtc ggctcgaagc ggtccacgat cggctgcacc
     8701 gaccgccgtc ccgggccccc gtgcaacacc atcagcgtct tggtcatgac cccaccttaa
     8761 cgaacatgtt cgttacgaac aagttcgtca gtggattccc tggttcttac ccagtgctta
     8821 cgctggaccg gacgcacgtc acagccggga ccaaaaccgt cctgaccggt gttgtatcga
     8881 ccggggggaa cggatcgaga gagggagcga tgagcaacac gaccgagacc gcggtgctgg
     8941 ccggcgggtg cttctggggc atgcaggacc tgatccgccg ccagcccggt gtgctgtcca
     9001 cccgggtcgg ctactccggt ggcgacacgc ccaacgcgac ctaccgcaac catgggaccc
     9061 acgcagaggc cgtcgagatc gtcttcgacc ccagcgtgac cagcttccgc gacctgctgg
     9121 agttcttctt ccaggtgcac gacccgagca cgaagaaccg ccagggcaac gacatcggcc
     9181 tgagctaccg gtcggccatc ttctacacca gcgacgagca gcgccgggtg gccgaggaca
     9241 ccatcgccga cgtcgacgcc tccggcctgt ggccgggcaa ggtcgtcacc gaggtgcagg
     9301 ccgccggccc gttctgggag gccgagcccg agcaccagga ctacctgctg cgctacccga
     9361 acggctacac ctgccacttc gtccgtccgg gctggaagct gcccaagcgg gccgagtcca
     9421 cgcagggctg acgccctgag gtctggcggc tgacaccccg tcagccgcca gacgggcagt
     9481 acccctggca tatgaacggc ccggcccggt cggggtcgag ttcccagtag tgcacgccgc
     9541 gatccacgcc ggccgagaac agcgcgtccc cacgcgagcc gaaccgcatc gcgtccagca
     9601 gccgctggtc gaaggcgacg ttcgactcga tggagcggcc ggcgaagaac acgtgccgcg
     9661 agccgtagcg gcgctgcatg gcccgccggt ggtccggatg gttcgcggca atgtcacccg
     9721 atggtggggg acggttgcca gtaggggccg aggagcgggt gaccggggga tctaccgaca
     9781 cgggtagtgc gggaccccgg acggcctagt cggccacccg cgagagtgaa tgccggacgc
     9841 ggggagtgat tggttattca cacgaactag tcctgtgcgt gccgtagtgc aaccacatag
     9901 acttatgccg aaatttgcag atatggctat gcaaaaagcg cagtcgtccg gctcgtccag
     9961 tccgacggca acttgccgtg gacaaggaag gggctcgccg atgttcacaa tcacgccgtt
    10021 agccggttcc cgcgccgaca accacgacca cgtgctggtc gggttgagcc cgcagaacgg
    10081 gcggtacaag ccggaataca tccgaaacct gatttcctgg ctgcatcccc gattcagatc
    10141 gattgacgtg gtcattccgg ggttcgaggc ggcatacacg ctggtcgcgg ccggccaccc
    10201 gcccgcccag gcggtgcacc gggcccgcag ggcctatcgc cagctgcgca acccggccgt
    10261 gcaagccctc gccgacctgg gggttcccga cgcggccagg catgtgatga gctggacccg
    10321 gctgcacgcc gaccacgctt accgagccgc gctgaaccga tcccgaatcg cctatatgac
    10381 cgacccaggc attcgccggg cctgccgtga gatgacggcc gaggtggtgg ccaactcggc
    10441 cgcggggcac ctggtcacgg accgggatat cgacatcgcg gtccgttacg tgattgccga
    10501 aataccgctg ctcacggacg gtccgagcct cttcgggacg aacggcagcg tattcgtgta
    10561 ccaccgtgcc accccactgg tggcggagat cgcccgtagc gactccattc tcagcgcaca
    10621 gcccggacag gcgtgggcgg tcgtcgagca aaaggagcaa aatcatgacg agcacggccg
    10681 aaccagatct tccgctgcac tacccgttcc cgctcggtga caccggcgcg ctgccgccgc
    10741 tgaccgcctg ggcccagcag gccaagccgg tctgcccggt gcggctgccc agcggcgtca
    10801 cggcctggat gctgacccgc aaggacgacg tggcccaggc gctggccgac aaccggttca
    10861 gccgcaacct ggccgagccg ggctcacccc gcatggtcgg cgaggacctg acctcggtgg
    10921 accacgcgat cttcaacctg gacccgccgg agcacggccg ggtccgccag gtgctcagca
    10981 gctggttcac ccgccgcgcc gtgcagcggc accgcccgct ggtggcccgg cacgcgcaac
    11041 ggctgctggc cgcgatggcc gacggcccga acccggtgga cctggtcgag gcctacacgg
    11101 cgacgctgcc gctggacgcg atgggcgagg tgatgggcgt gccgccggac ctggcgcagg
    11161 agtgccgccg cgtctacccg atgagcctgg acctgtcctc cacgccggac gcggtggaga
    11221 aggagaccga cgcggccaag cagttcatcg ccaagctgat caaggtacgc cgggcggagc
    11281 cgatgccgga ctcccccgtg cacgcgctca tcgaggcccg cgagcagggc ctgatcaccg
    11341 aggccgagat gttcggcacg gtgttcctga tcttcgtcac gtcgttcgac ccgctggtgg
    11401 ccccgctgac caccgggccg atgatgctca tgctgcaccg cgcgcaactc gccgagtgcc
    11461 aggccgatcc ggccctgtgg cccaaggcgg tcgaggagat cctgcgctac ttccacaacg
    11521 gcggcctggg tttcccgcgc gtcgcccgcg aggacgtgga gctgcgcggc acgctgatca
    11581 gggccggcga cgcgctggtg gtgccgatgc aggcggtcac ctgggacccc cggcactacc
    11641 gcaacccgga gcggttcaac atccaccggg ccaccgacgg gtcggccacc ttcggcgccg
    11701 ggccgcacta ctgcctcggc tcccagctgg cccgggttgt cttgcaggag gccatctccg
    11761 cgctgttcac ccggttcccg acgctcgacc tggcggtcag cgagcgggag ctgccgtggg
    11821 acccgaaccg catgttcacc cgcccgatgc agctgcccgt gacctggtga ggagtgacat
    11881 gacggcgagc cagttcgagg agttggccta cctgtacgag cacagcttcg aggtgtggcc
    11941 gtaccggcgg gacgtggagc agcactcggt gctggcggcg ctgggcgagg tggccgggct
    12001 ggccgcgctg gacctgggct gcggcgccgg ctcgtacacc cgactgctgg ccgagcacgg
    12061 ggcgcggccg gtggtcgggg tggacagcgc ggccggcatg gtcgactacg cccggcggcg
    12121 cgaggccgag gacccgtccg gggcgacctt cgcccggcgg gacgcctcgg agccgatctc
    12181 cggccgtttc gacgtggtgt tggcggtgca cctgctgccg tacgcggaaa cggtcgagac
    12241 actcaccgcc atgtgtgcga cggcgcggtc cgccctgtcc ggaccaggga aaatgttcgt
    12301 gaccgtcacc atcaatcctg gtttcgccac cgaacccggt tactacacac gctacggatt
    12361 cgacttgata gccccttcgg ctgaacttcg tgacggcgat ccggttcggc tgcgcagtga
    12421 gttcctcggc ggcagcatcg acgtcacgcc acacttctgg tcccgcgcca ctcaggagaa
    12481 agccctgctc aacgcgggtt tccgggaggt gacgtggtgg gctccgcagt gctcgccgac
    12541 ggccgacgtc gatcacttcg gcgattatct ccgcaaacct cccacccttg ttgtcaccgc
    12601 gacggcgtga ggctgtacta ggatttccgc ggcgaatatg aagttttccg ggaggtcggg
    12661 ctcgtgcacg aatcggcgtg gatgccaacg ggactggatc cggatgtgcc cagtgccgcc
    12721 cgggtgtacg actatttcct cggcggctac cacaacctgg ccgtcgaccg ggagttcgcc
    12781 caccgcgccg agcagacgat gccggacctg ccgctgatcc tgcgcacttc acgccggttc
    12841 ctgcggcggg ccgtgcacta cctgctggag cagggcatca cccagttcct ggacctggga
    12901 tcgggcattc cgaccgccgg caacgtgcac gagatcgcgc acgcggccgc cccgcgctcc
    12961 cgggtggtct acgtggaccg ggactccgtg gccatggcgc acgccgccct gatgctggag
    13021 ggcaacgaca acgccgccgc gctgcgggcc gacctgagag acccgcggga ggtgttgcgc
    13081 cacaacgtgg tcaccaacct gctggacctg tcccagccgg tggcggtgct gatgtcggcg
    13141 gtgctgcact tcgtcgagtc cgatgtcgag gcgcagtcca ttgtggccgg ttaccgcacc
    13201 gccatcgcgc cgggcagcta catcgcgatc tcccagggca cccaggaggc cgcgggcgag
    13261 cggggcgagc aggtgatccg cctgtacgac cagaccgaca gcccgttcac ggcccgcgac
    13321 cgcgggcggt tcacccggct gttccggggt ctggacctgg tcgagccggg cgtggtctac
    13381 gtgccgcagt ggcggccgga gtcgcccgag gacgttgacg agcaccccga gctgagctgc
    13441 gcctacgggg cgatcggcca gaagccgctg tactgacgcc gggttctggc cgatcggcca
    13501 gaacccgatt ccacaagttg acaatcattg tcgccgcgct cacgataact gactgatgag
    13561 ccagttatct acggagcggt gatgcacgga ctgggcgtgt tccgcgaccc cgcctcggtc
    13621 gcggtggtcg gcgcgtcgga ggaccggtcc aaatggggcc actggctggc ggccggagcg
    13681 ctgaccggag ccggtcgacg gcgcgtgcac ctggtcagcc ggcgcggcgg caccgtgtgc
    13741 gggcagccct gcgcgacgaa cctgcggagc ctggacgagg tgccggagct ggtggtgctc
    13801 tgcgtgccgg cgacccacgt gccggaggtc gtgaccgagg ggctttccct gggggtcaag
    13861 ggattcctcg gcatcaccgc cggcgtctcg gacgaactgg agctggcgcg acggatccgg
    13921 tccggcgggg cccggctggt cggcgcgaac agcctgggca tcgtggacac ggccaccgag
    13981 ttgtgcctgg cctggggcag tttcaccgcc ggaccgctgg ccatcgtgtc gcagagcggg
    14041 caggtcggct cggagctggc gctgctgggc gagcggcacg ggctgggcat ctcccggttc
    14101 gtctcgctgg gtaacgccgc tgacgttacg gcgaccgagc tgctggccga cctcgccgac
    14161 cactccgcga ccgaggtggt ggccgtctac ctggagaact tcacggacgg atcgctgctg
    14221 ctgcgggcat tgcgggggct gcgggaggtg ggcaagccga cgctgctgct gaccgtcggc
    14281 ggcagcgcgg ccagcacccg gctggcccgc tcgcacaccg gttccctgac ctcgccgctg
    14341 gacgtcgtgg acgccgcgtg ccgggcggcc ggggtcgcgc gggtgagcac gccgtcggag
    14401 ctgatcgacg tggcccgggc cctgctggcg gcccggccgc cgcacggcga ccgggtggcg
    14461 atcatcggcg acagcggcgg gcagtgcggg atcgccgccg acgtggccca cacgaatcgg
    14521 ctcacggtgc cggcgttctc gcacgacatc ggcgtcgcgc tgccggccgg gtcggccgcg
    14581 cacaaccccg tcgacctggc cggggccggc gagcaggaca tcgccaacta cgcccggatc
    14641 accgaggcgg tgctgcgtcg cgacgacgtg gacgccgccg tgctgaccgg ctacttcggc
    14701 cggtacggac tggacattcc ggccatcggc ggccgggaag tcgcggtggc gcaacggatc
    14761 ggcgcggccg tggccgacgc cggcaagccg gtggtggtgc actcgatggg cccggacagc
    14821 gccaccgccc acgccctgtg ggcggtcggc gtcccgacgt acgaccgcat cgaggcagcc
    14881 ctgtcggcgc tgcgcggtct ggtcgcgttt gggcggccgc ctgagctgcc gctgccctac
    14941 caagcccggc ccctcgacgc cctgcccgag ggctactggg agactcgcca ggtgctcgtc
    15001 gacgtcgcct tcccccgggg cctcgtcgtc cgcgcccggg cggagctggc ccgggcggcc
    15061 cggctcaccg ccccctacgt gctgaaagcc gcctggctgg agcacaagag cgaggccggc
    15121 ggcgtccgga tcggactcgc caccgtcgac cagctgaccg cggcgtacga cgagatgtcg
    15181 gcccgcctgg gccccggtga ctacgtcgtc gaggagcagg acatccgccc ggacaccgtg
    15241 gagatcctca tcggcgcccg ccgcgacccc gacttcgggc cgttggtcgt ggtcggcgcc
    15301 ggcggcacgg agaccgagct gcgccaggac atcgccaccg agctggctcc cgtctccccc
    15361 gccaccgccc gggacatgct cggccggctg cactgtgccc cgctgctgcg cggctggcgc
    15421 ggccgcccgg ccgtcgacat cggggggctg gccgatctgg tgcaccggat gtcgttgctg
    15481 gtggcggctt cgccgctggt cggcgagctg gagctgaacc cggtccgggt cgggccggac
    15541 gggccgctgg ccgtcgacgc cctgatcttc cctgtagccc gtcaggaggc acgccacgca
    15601 tgaccaccca cttcccggcc tggccgctca gcgccgaaca acgccagatc gtcaacctgt
    15661 gcagggactt cgccgagcgg gagatccggc cacgggcgcg ggaggtggac gaggccgacg
    15721 tggtgacgcc ggtggacctg ttcgccaggg ccggcgaggt cgggatcacg aacttcatgc
    15781 tcccggagga gtacggcggc ggcggtttca ccgacgtgtt cacccagtgc ctggtgcagg
    15841 aggagctgtg ctggggcgac ccgggcatcg gcaatctgct gtgctccaac ggtttctacg
    15901 ccgacccgat cctggagctg ggcaccgggg aacagaagaa gcagtggctg accccgctgg
    15961 ccggcccgga cgcgccgatg accgcgctgg ccaccaccga gcccaacgcc ggctcggacg
    16021 cggcctcgat gatcaccacg gcccgccggg tcgagggcgg ctacgagctc accggccaga
    16081 agacgtggat ctccaacgcc ggcacggcca agtactacgt ggtgttcgcc aagaccgacc
    16141 gcagcaagcg ttccgccggc gtcaccgcgt tcctgctcga acgggacgcg ccggggctgc
    16201 ggttcggcga gccgatgcgc aagatgggcc agcgggccat cgtctgccgg gaagtcttct
    16261 tcgacaacgt gttcgtgccg gcgagcgacc ggctcggcga cgagggccgc ggtttccacg
    16321 gcctgatggg cacgttcgac atctcccggg tggtgctcgg cgcggcggcg gtcggcgcgg
    16381 cccgggccgc ctacgagttc gcgctggact acgcccgcga gcgcaagcag ttcggcgtgc
    16441 cgatcatcga gcaccaggcg gtggcgttcc ggctggccga catggccacc cgcatcgagt
    16501 cggcccggct gctggtgcac cacgccgccc ggcagatcga cgccggccag cgggtcaccg
    16561 ggctggccgc gatggccaag ctgaccgcgt ccgagacggc catgttcgtc acctgggcgg
    16621 ccgtgcagac gctgggcggc tggggctact cccgggagtt cccggtggag cagtggatgc
    16681 gggacgtgaa gctggaggag atcgaggagg gcacctcgga catcatgcgc ctggtgatct
    16741 cccgtcatct ctgactggtg agccagttat ctatactcgc ggtcgcaccc atcgggagga
    16801 gtgaccgtgc cgcgtcccag cgtcgaggcc gagcgcaagg cgcagatcct gcgcgccacg
    16861 tgcgcggtga tcgccgacgc cggcatccac gacctgcggc tgaccgacgt cgcccggcgg
    16921 gccggcgtca gctccggcac catccactac tacttcgaca gcaagcaggc cctgctgcac
    16981 gcggccttcg agcacaactt ccggcactcc ctggaacgcc gggccgccgt gctggcgtgc
    17041 ggcggcagtc cgctggacct gttggcccgc ctggtcgagt cgtacgcgcc gctggacgcc
    17101 gagagcgtcg ccgcctggcg ggtgtgggcc gagctgtggg tgcacggcct gcggcagccg
    17161 gaactccagg agctcaacga gagcatctac ggcgagtggc ggcggaccgt ggtcggcctg
    17221 gtccgggacg cgcaggacca gggcctgctc aagggcggcg atccggtgct ggtggccaac
    17281 accgtggtcg cgatgatcga cgggctggcc atccaggtgc tgctgggctc gcggaacatg
    17341 accgtggacc ggatgcgcgc cacctgccgg gcctacctgg actcactggc cgacggttag
    17401 gcggacgcgg gtcagcgccc gccagccggc ggccgccgcc agcagcatcg ccagcccggc
    17461 cacgccgaaa cccagccgtg gcccggcgac tcccgcgacc caccccatga acggaccggt
    17521 gaccagcgtg cagcccggca gcgccatgct ccacgccgcg ttcacccggc cccgcatgcc
    17581 ggggtcggat tccagctgca ccaccgtgtt ggccagcgag atgaaccaga ttgaaacgca
    17641 gccggtgacg gccatggcgg cgaacaccag cggcacggtc ggtgcgtacg cggtggccag
    17701 gatcgacagt ccggtgccac cggccaggat caccacccgc cggccgctcg gccggctcgg
    17761 accggacgcc gccagcagca cgcccgggag ggagccgacc ccgaacgtgg ccatcatcag
    17821 tccgaaggcc gtgccgtcga ggtggaacac gccggtggcc agcagcggca cgggcacgtt
    17881 gaggctgaac aacattccgg acgccgccgc cagcaacaga caggcccgga tcaccggatt
    17941 ccgccaggcg taacgcaatc cgccgatccg ctgcggccgt ggcgggtgcg ccgtctccct
    18001 gacccggtgc cgcagcacca cgatcagcgg cggcacgaag gtcagcgcgt tgaacacaca
    18061 acaggccgcg gggccccaga atccgagcag cgcgccgccg atggagggcc ccaggatccg
    18121 ggccccgttg accacgacct cgttcagcgc caccgcgttg ctcaccccgt cggcgccgac
    18181 caggtcgaag acgtacacct gccgggcggt ggcgtcgtgc gtgctgacga tgccggtcgc
    18241 cgccgcgatg gcgaacagca tccagatctg cacgaccccg gtcgccgcca gcaccgcggt
    18301 cagggtggag atcgacgcca tcaggctctg cgtgacgatc aggacccgcc gcgggccgat
    18361 ccggtccacc agcgcgcccg cgtacgggcc gaccaggaac agcggcagga aggtgcaggt
    18421 ggacatcagg cccaggtcaa ggccgctgcc ggtgagctgg agcaccagcc aggacagcgc
    18481 caccccctgg gtcacgcccc cggacgcgga gaggagctgg ctgaggaacc actgccggaa
    18541 caccggttcc cgcagcgacc ggaagctgcc cggcatcagt cccccatcac tcgacgtcgc
    18601 ctgatcttcc tcccccgcgc gcccaccggg ccaccgattt ctcaccgcgt caacgccgcc
    18661 ggccggtcct gtccgatcct gtcagctgaa ccgtcacagc gcttgacacc acgattggtc
    18721 cagtccaccg tacgggtcgt tcgcggaccg accccatgga ggaagaccat gcggcatccc
    18781 gccgtgctcg cgttggccac gcccctgctg ctgctcacgt tcgccgggac ggcgccggcc
    18841 cagccgtcct cgtcgaccga cgcgttcaac agcctcaccg cggagagcca cccggactgg
    18901 atggccggcc tgccggcgca ggccagcctg gcggcgctga gcatccccgg cacgcatgac
    18961 acgctcgcca tccacggtgg gctgctgccg gccttctacg aggcccagga ggaccacggc
    19021 gacagcgcgg cgaccctgga cgcgcaactg gccgccggca tccgggcgat cgacatccgg
    19081 gtgcgggtgg tgaacaacga caccgccttc gccgtccacc acaccgatgt gtaccagaac
    19141 gcgaacttcg acgacgtgct gacgcacgcc cggaacttcc tgtccgcgca cccgggcgag
    19201 accgtgctga tggacctgca cggcgaatgc gacggcgact ccaccgaggg cggcagcggc
    19261 agcggctcga tcgggcactg cgccgacgat ccgtccacca tcacgcaggc cgaccggacc
    19321 cggatcttca acgactacgt gtcccgctat cccggcctgt tctacgcgcc cacggtgacc
    19381 ggcgccagca ccgcggacat gccgacggtc ggccaggcgc gcgggcacat cgtgctgacc
    19441 acgttcaccg ggccgcgcgg ccaggtctac ggcggctacg gcctgaccca gctgaccacc
    19501 ggcgactggg gccagtacgt ggagaacgac tggacgcagt gcgacgtcaa cagcaagttc
    19561 ggcgaggccc aggccaacat ggccaaggcc gacaccgcca ccgcgatgta cacgacgtac
    19621 ctgtcggcga actgctcgcc gttcggcgcg gacccggagg acatggccaa gggcatgaat
    19681 ccgcgcaccg tcgactacct caacagcggg gccaccagtc atgtcggtgt cgtgctgacc
    19741 gacttcccgg gccacgccct ggtctccgcg ctgatccggc agcagtccgg cctgctggcc
    19801 gggccggtgc cgtcgggcat cgccggcaag tgcctggacg actacaactc cgcaactgcc
    19861 ccgggcgcga ccgtggacct gtgggactgc aacggaaccg gcgcgcagca gtggaccgtg
    19921 atgccggacc gcacgctgcg gaccgccggc ctgtgtctgg acgtgaccgg cggcggcacc
    19981 gcgaacggca cccacgtgca gctgtggacg tgcggcggcg gcagcaacca gcagtggacc
    20041 tccggcccga acggctcgct ggtgagcgtg cagtccggca agtgcctgga cgacccgggc
    20101 gcgtccacgg ccaacggctc gcagctgatc atctgggact gcggcgcggg ggccaaccag
    20161 cggtggacgc tgccgtagtc cacagtggag agcgactaat cggtcatttc ccttgccaac
    20221 agggcggacc accgggcccg gtggtccgcc cccagctttt tcccagtcgg cgggctcttg
    20281 acggggacag gtggtctagt ccactttcgg gggagcactc cacggccgcc cgtcggaggt
    20341 aacacatgcc gtccctgtca cgcatccgcc tcggcatcgc ggtggcgctg gccgccgcca
    20401 tgaccgccct gctcacggcc gccctgacgc tggccccgtc ggccaccgcg gccaccaacc
    20461 tggtcgccga cgccggcttc gagtccggcc tgaccggctg gacctgcgac gccggcaccg
    20521 cgaccacggt gtcgacgccg gtgcacgccg gcacgaaggc cctggccggc acgccgtcgg
    20581 ccagcgccac cgcccagtgc acgcagacga tcagcgtcgc cccgaacagc gcgtacaccc
    20641 tgaccgcgtt cgtccagggc tcctacgtct atctcggcgc caccggcacc ggcgtcaacg
    20701 ccagcacctg gacccagtcc
//
