LOCUS       NZ_CP073318            23174 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2141726
            Orig. end                         :: 2164900
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23174
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="indole"
                     /region_number="17"
                     /rules="(indsynth or dmat or indole_PTase)"
                     /tool="antismash"
     cand_cluster    1..23174
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(indsynth or dmat or indole_PTase)"
                     /kind="single"
                     /product="indole"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23174
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:13174](+)"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13174
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(indsynth or dmat or indole_PTase)"
                     /neighbourhood="10000"
                     /product="indole"
                     /protocluster_number="1"
     misc_feature    993..1006
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 19.86"
                     /tool="antismash"
     misc_feature    1712..1726
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.52"
                     /tool="antismash"
     misc_feature    complement(1713..1728)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 16.65"
                     /tool="antismash"
     gene            1891..2163
                     /locus_tag="JJ691_RS09510"
     CDS             1891..2163
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS09510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_211768408.1"
                     /transl_table=11
                     /translation="MHSAAVADRARYRPFRSSSALESALCGAFVAANSPLTCAAPFIPH
                     RRIGKCIHIAREKRAPRWMAAALGFAIPVLRQSAQSMIMLASVIR"
     misc_feature    2113..2115
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(2485..3681)
                     /locus_tag="JJ691_RS09515"
                     /old_locus_tag="JJ691_18980"
     CDS             complement(2485..3681)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003103318.1"
                     /locus_tag="JJ691_RS09515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_18980"
                     /product="cytochrome P450"
                     /protein_id="WP_211768409.1"
                     /sec_met_domain="p450 (E-value: 2.6e-18, bitscore: 65.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METVPFYPMQRATECPFDPPPGLREMGPIGRVRIWDGSTPWVVTG
                     YEAHRFVLSDQRFSADARRDGYPAESAAVAERIHDFRSLIMMDEPEHGAQRRMLSKNFT
                     LKSVEAMRPRVAQIVDGLIDDLLAGPNPVDLVAAFALPVPSLVICELLGVPYDGHDFFQ
                     DCSRKLFSQSCTVEETLEAHVALQEYMLKLVDAKDTEPGDDMISRLVAEQLRPGNLSRA
                     EIAEMALLMLVAGHESTANMIALGTLALLRHPDQLAALRDADDPKEIAGAVDELLRYLS
                     VVHVGRRRVATEDVELAGQLVKAGEGVILADGASNRDESVFPAPDTLDLQRKGRQHVAF
                     GYGSHQCLGQLLARMELQVVCGTLYRRIPTLKLAIPFDEVQFKHDMVVYGVRSLPVSW"
     gene            complement(3751..4458)
                     /locus_tag="JJ691_RS09520"
                     /old_locus_tag="JJ691_18990"
     CDS             complement(3751..4458)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019814690.1"
                     /locus_tag="JJ691_RS09520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_18990"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_211768410.1"
                     /transl_table=11
                     /translation="MTEPTGLENPEFLATGFENPEFWNSMYDNNTAPWLIGEPQPAIVA
                     LEREGLIRGRVLEPGCGSGEHTILFTKLGYDAIGVDLSPSAVAYARRTAAEKGVPNARF
                     EVANMLHPGDHSALTPAFDTIVDCALFHGFGAYGRDMGTPKAYAKVLHSICNPGGLVHI
                     LAHSDAEPGLSSQISDAVIRESFDDGWELEDLQPARYQGYVTEQIAETATNAGLPAHGP
                     IDLAAWLARIRRI"
     misc_feature    complement(4438..4440)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(4621..5778)
                     /locus_tag="JJ691_RS09525"
                     /old_locus_tag="JJ691_19000"
     CDS             complement(4621..5778)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062: glycosyltransferase, MGT family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF044385.1"
                     /locus_tag="JJ691_RS09525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19000"
                     /product="nucleotide disphospho-sugar-binding
                     domain-containing protein"
                     /protein_id="WP_211768411.1"
                     /sec_met_domain="MGT (E-value: 2.1e-112, bitscore: 375.4,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLVTASPGLGHMLPMVSISWALRAAGHEVLLAMAGSGAQHVPT
                     LAASGLHVVETQPYESVVRLIDAAHASMDIQAVQQMIREASRDVERLIGFGAQVFAPQS
                     DLVADTVVAIADEWRPDLVVHSPIDGAGPLAAAKLGVPAVEQAYGLLSAEDQVTQVAEA
                     LTDTYRRHGVDGPPTRHALLNVAPPSMGTPDLGWAMRYVPFNGGGQLPDWLLHRPDRPR
                     VIVTIGTVIPGLVGLGPLQWLADVAGGFDAEFVVTLDNAEAGQFGALPDNVRPVSYTPL
                     NALLATSTAVVHHGGAGSTMTSLAMGVPQLVVPQGSDQFHNAREVTKRGVGFEVDTAVA
                     PVDANDVTRLLTDASLATAAAEVKAEIAAQPAPADLVPRLVELVG"
     gene            complement(5778..7463)
                     /locus_tag="JJ691_RS09530"
                     /old_locus_tag="JJ691_19010"
     CDS             complement(5778..7463)
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012935.4"
                     /locus_tag="JJ691_RS09530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19010"
                     /product="GMC family oxidoreductase N-terminal
                     domain-containing protein"
                     /protein_id="WP_211768412.1"
                     /transl_table=11
                     /translation="MKSLEADWIVVGGGPAGCVLASRLSEDASKRVILLEAGPDWRSSA
                     APREIRSLNGWRPLDSAECRRFYWPGLEALRTPHQATRPYLRGRGLGGSSLINGMMAIH
                     ARPDDYDRWAAAGCDGWSYQDMLPYLRRMEADADFGNQTYHGSDGPMPVERLPRERWEL
                     LDDRFAVATLDLGYPWCEDYNAPTGTGVSPIALSVRDGARVTTNDAYLEPVRERANLQI
                     VGDATVERVLLDGHRTTGVRVRVGEERIDVRGGAVVLCAGAIHSPAILLRSGIGPGKEV
                     ADLPVGDGLQDHPLALFWLDLQPEAHPAGIDSRQYNCCVRYSSGLAGENDLMMIHMNRP
                     PAMTSLGVEGDAPAQEATGTWGVGLGDNHDHQPEVRPSTDPSLLALVENQVVSRGRLVL
                     ASDDPDAPPRIEHNMLGEASDLVRLREGVRRVRELVATPPFAEVIRHVAIDPMGRGLDS
                     LADDAEIDRWLLETVGDAAHLSGTCRMGSPDDARTVVDPTGRVLGVDGLWVADASVFPE
                     IPRANTHFPTLAAAERISDLARGIAEPAATAGASGAASFPHRGF"
     gene            complement(7487..9103)
                     /locus_tag="JJ691_RS09535"
                     /old_locus_tag="JJ691_19020"
     CDS             complement(7487..9103)
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013646.4"
                     /locus_tag="JJ691_RS09535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19020"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_211768413.1"
                     /transl_table=11
                     /translation="MRDEHDCDVLVVGAGPTGLCAALVLAQQGVRVRIVDRKAGPVEQA
                     RAAIVHARTLEYLDRLGVADAAVARGRLITNVAIHEGGRHAGDMPLAGKGTTDQTRFPY
                     ALALEQFETERLLAEALAEHEVAVGWNCEVRDLTDTGDGVRVQLAAEAGPTTITARWLV
                     GADGASSTIRRILGQEFEGETYEQAGMLADVTLDVELGVQGMRLSLTRGGFVGILPLAS
                     GRCRLFGVVPPELHQAPAQRGGPSHESYAPLAHADLQRWFDDYFTVDANLREVSWASMF
                     RFHSRLAARFRVGNAFLVGDAAHIHNPAGGQGLNLGIGDAVNLAWKLAQVVNGEAPEWL
                     LDTYESERRPIAETVLKRTDVGFKLETTDNPVATWMRANVATRVVGVVSRLAPVRRLVF
                     HMFSQLWINYRGSRAVGPGVGALKPGDRAPFAPIESTRDGARSVLDLTHGAGYHLLVFS
                     ADNTDTDELASQLTARYHASVTTHVIPAGEHAAYRAYQVDGPRLVLVRPDGHIAALAAP
                     SSVDPLITYLDTVLTKARVPR"
     gene            9312..10004
                     /locus_tag="JJ691_RS09540"
                     /old_locus_tag="JJ691_19030"
     CDS             9312..10004
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (34-140). E-value: 2.2e-12. Score:
                     37.7. Matches aSDomain: nrpspksdomains_JJ691_RS09540_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013382.4"
                     /locus_tag="JJ691_RS09540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19030"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_211768414.1"
                     /transl_table=11
                     /translation="MTAAEPYFDDLAELYERFTQVRDAATSPVRSWLTAQLSTGARAID
                     VGCGGGNNCGLLADRYDEVVGVDISQKMLDIASTKPTRVPVRYECRSATDLTPDRDGQF
                     DLVMSVNAVFHMGPAEVVLPTLRDLVAPGGRLVIIDVTQPDDGAEPREQSAYAFETGKI
                     VYDVSGDVAAAVDSIRMMLHPRWLEMSAQAAPLSETEFTVQYEKALPGVRITKNVIPTM
                     SAAVWDAA"
     aSDomain        9414..9731
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS09540_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.20E-12"
                     /label="JJ691_RS09540_oMT.1"
                     /locus_tag="JJ691_RS09540"
                     /protein_end="140"
                     /protein_start="34"
                     /score="37.7"
                     /tool="antismash"
                     /translation="AQLSTGARAIDVGCGGGNNCGLLADRYDEVVGVDISQKMLDIAST
                     KPTRVPVRYECRSATDLTPDRDGQFDLVMSVNAVFHMGPAEVVLPTLRDLVAPGGRLVI
                     ID"
     gene            10001..13174
                     /locus_tag="JJ691_RS09545"
                     /old_locus_tag="JJ691_19040"
     CDS             10001..13174
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) indole:
                     indsynth"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024306.4"
                     /locus_tag="JJ691_RS09545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19040"
                     /product="ferritin-like domain-containing protein"
                     /protein_id="WP_211768415.1"
                     /sec_met_domain="indsynth (E-value: 0.0, bitscore: 1257.5,
                     seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFDLPRVHFAGVAVTRLPTGPRAGLLDLETNRAVTDDGVFDTA
                     RPAREYHEFLAAKGVEGTNFAGNGHFWIDAAVVGCERAPGVVDVEDLLVGRQLDLWGHY
                     YEYTAGTANRSRVFDVDPASNWTTTVMVGQLALGRLGRSHEVGYLVTGDVSGMCPPRWQ
                     NTAYVRDDGVDPRFRRSVLHQFVVDRAEGLHWLSGAEDSPTLARLRELVESGAADGLVV
                     QFALTNMATPTADGEPDFWDLRGTIAPWHGTELRTYPVGRLLTPRAAANSALHNLSVHV
                     GDDVVTANLVSAIPVTSRADTRGPGPTHRLGPFIDLGDLDVRTSSGTVLATIPRAAYLG
                     DAYRLTSGVLVAQRVDGGTGNPGEALMITAADGTVLAREEETVVESDEASLFLEHENPK
                     TGEDHAVEIPIRSYVRGEPGRVDRILVRQYVNPRGRPLDDDHEQVRIAEFLVAGQQDYR
                     PDCVASTDEHGRGAIAIKGIRGGAAKILLLPDGQDLPRGVNTAERYDNDDEQGYWSAVG
                     SVALRVLPNHWHLDDLPDNEITFPTLYREALAYYELQYSFMRAEVFSLADEFKVEPYAR
                     LMCHASEPERKSKTYYMPPTRDMSAPQVRLMRRYLLADEARRQTPPTMVPQHRKLGVIT
                     TKEQLLHALYQAAAIELATMIQYLYAAYSVPLHSAGRQYVARGEWTPEQLLIACGDGTQ
                     SWKNGIRGNLMCVAREEMMHFLTINNILMAMGRPFHLPRLDFGEFNSKVCVPLEFSLEA
                     LNLASVQRFIELEQPHDLIDEVEGNDSTVLRPDGEPYRYGSLSELYAAIREGIQAVPGV
                     FLVKKGRAGGAHHLFMRESVNAVHPDYQLEVDDVASAVFAIDFVTEHGEGGHIPSTLPA
                     EESHFDTFLRICDLLVHERATGPNDRRIPWHPAYPVLRNPTLRPGNPTMDLVTHEPARL
                     AMTVFNRSYFMAMQLMVQHFGHSSDKSLRRSRLMNWALDIMTGVLRPLGELIVTLPSGR
                     PGRTAGPSFELDEEPVYIPRPDIAVEWMAREFDEIAVLARKCAGLTPTVADLLAFLGEQ
                     LRAMDLKEL"
     gene            13174..14430
                     /locus_tag="JJ691_RS09550"
                     /old_locus_tag="JJ691_19050"
     CDS             13174..14430
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004834.1"
                     /locus_tag="JJ691_RS09550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19050"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_211768416.1"
                     /transl_table=11
                     /translation="MTRTKNTTVCVAGGGPAGAMLGLLLARSGVDVVVLEKHADFHRDF
                     RGDTVHPATLQILDEIGLVDRFHELPHQKVPTIGVVQDGRRIDIADFRRLRVRYPYMAF
                     VPQWDFLDLITAEAARYPAFRLMMRTEAVDVLRDGGRVVGVRARGPEGELDIRSTVVVA
                     ADGRHSAIRRAVGVTPRLIGRSLDVIFFRISRRDTDPDEGICVRIGNGKIFGATDRRTY
                     WQMSYETTAGGMAKVIAAGLDAFRADLAAMVPFLADRVHEVASYEDLSLLEARIDRLDR
                     WHQPGLLFIGDAAHAMSPVAGFGVNLAVQDAVATANALVAPLLRAQRTGAAFDHSRLAA
                     IQRRRRLATALSQGLQRATQRFGIDDALNGSGQPPAPKLFEKLAPAQWLMSRIIGLGFR
                     PEHVRTPAASPAQTEGTRG"
     gene            14427..15425
                     /locus_tag="JJ691_RS09555"
                     /old_locus_tag="JJ691_19060"
     CDS             14427..15425
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013087.4"
                     /locus_tag="JJ691_RS09555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19060"
                     /product="methyltransferase"
                     /protein_id="WP_211768417.1"
                     /transl_table=11
                     /translation="MTPHQRMMSMITGYWVTQIVHAVAELGIADHLADGPRTSAELAEL
                     TGCDPDAMSRLLRACAAQELVGVRSDGTFETTPMLALLSEGVPHSFRDIAIVHGSPGHW
                     LSWGRLPDAVRAGEPQTKAALGMDIWDHFADNPVEHGRFVNSMTELTAGLSEEIAGLLD
                     VTGVGVAVDVGGANGALLHAVLRSNAEMRGLLLDLPAVTATATAEAAKAGLSDRVTVVG
                     GSFFDPIPAGDLFLLKAVLHNWDDEACVRILSNCRAALNPGGRVVVVEMPLGPMGEPGF
                     APLLDLNMLAVVSGRERDLDHYDDLFAAAGLRRTRMTPTRSPQCLIEAVTA"
     gene            15460..17001
                     /locus_tag="JJ691_RS09560"
                     /old_locus_tag="JJ691_19070"
     CDS             15460..17001
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Trp_halogenase"
                     /gene_functions="biosynthetic-additional (halogenases)
                     flavin-dependent trp 5 halogenase"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000030: Halogenation (64% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1119: halogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697894.1"
                     /locus_tag="JJ691_RS09560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19070"
                     /product="tryptophan halogenase family protein"
                     /protein_id="WP_211768418.1"
                     /sec_met_domain="DAO (E-value: 5.2e-10, bitscore: 38.6,
                     seeds: 521, tool: rule-based-clusters)"
                     /sec_met_domain="Trp_halogenase (E-value: 7.6e-139,
                     bitscore: 462.7, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKHVVVVGGGTAGWMTASYLTAAFGDRVSVTVVESERIGAIGVG
                     EATFSTVRHFFTYLGLEEKDWMPACNATYKLAIRFENWREPGHHFYHPFERQRVVDGFT
                     LPDWWLSAPASDRFDRDCFLVGTLCDNLKSPRRMDGALFEGDLSGDRSTYRTTLSEQST
                     QFPYAYHFDATLLANYLRDYAMARGVRHVVDDVVHVAQDERGWLSHVTTKQSGDLAGDL
                     FVDCTGFRSILLGKTLAEPFVSYQDTLPNDSAVALRVPLDMAHKGLRPCTTATAQEAGW
                     IWTIPLFDRIGTGYVYASDYSTPEQAEQRLREFVGPAAEDLPANHIKMRIGRSRRHWVR
                     NCVAIGLSSGFVEPLESTGIFFIQNGIEQLVKHFPDADWDEGLRDSYNQLISRCMDGVR
                     EFLVLHYYAARRRDNQYWQDAKKRPLPDGLAERIERWRTRLPDAETVYPHYHGFESYSY
                     VCMLLGLGGIDLKSSPALALLDPSSARHELKLVAEQAAELERTLPTQYEYFAQFR"
     gene            17014..18270
                     /locus_tag="JJ691_RS09565"
                     /old_locus_tag="JJ691_19080"
     CDS             17014..18270
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_process="GO:0006812 - monoatomic cation transport
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /GO_process="GO:1902600 - proton transmembrane transport
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1117:
                     sodium/hydrogen exchanger"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013188.4"
                     /locus_tag="JJ691_RS09565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19080"
                     /product="cation:proton antiporter"
                     /protein_id="WP_211768419.1"
                     /transl_table=11
                     /translation="MVLQNVLQLLALLGALCVAAAVGRLLARLARLPSVIGEIVVSLLL
                     GPALLATGGPAVYAAVLPQDLLAVLKEIGEAGLVLYLVGLVHRLDHGPGGLRGRGVRRI
                     TIGSLGIPLVAGLAFAGWVLWLAPPELRGHANASALVLMLAVTMSVTAVPVLARIIEER
                     KAALGRSAELAMMASMLIDTLSWLLLAVALGLRTGGIGGVLQAFVVLAVGGAIAWAAHR
                     GLATAWSTRLCASSPRLVAVVLGAVAITAGTGIRLAGLTAVFGAFLVGIMVPRTEGWSV
                     VVRWIGRIGRALVPVYFVVAGTTVFTGGVAALPWLAVVLAVALGILGKVLGGYLGARWG
                     GEDRLTSVRIGVLVNTRGLTEIVVLQVGYTAGLLTPGLLVALLVMALLTTALTGPLLDL
                     VDRRTAAGKALPVGESAVR"
     gene            18267..18767
                     /locus_tag="JJ691_RS09570"
                     /old_locus_tag="JJ691_19090"
     CDS             18267..18767
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1160: flavin reductase domain protein FMN-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016697893.1"
                     /locus_tag="JJ691_RS09570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19090"
                     /product="flavin reductase family protein"
                     /protein_id="WP_211768420.1"
                     /transl_table=11
                     /translation="MTISYAATSAGFRSLMAGFPTGVAVITTFGPDGEPWGMTCSSVCS
                     VSVEPPTLLVCVRAGSPTLAAMLRRGEFTVNLLHHGARPVAELFASGDPDRFDRVDWAV
                     PPVSGGPHLVRDAHAVADCRISRRQQVATHVVVFGEVVHVTQRPGEHPLLYGMRQYAAW
                     PVS"
     gene            complement(18813..19604)
                     /locus_tag="JJ691_RS09575"
                     /old_locus_tag="JJ691_19100"
     CDS             complement(18813..19604)
                     /NRPS_PKS="Domain: Abhydrolase_1 (35-168). E-value:
                     7.6e-13. Score: 40.6. Matches aSDomain:
                     nrpspksdomains_JJ691_RS09575_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024109.4"
                     /locus_tag="JJ691_RS09575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19100"
                     /product="alpha/beta fold hydrolase"
                     /protein_id="WP_211768421.1"
                     /sec_met_domain="PF00561 (E-value: 4.2e-07, bitscore: 29.1,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.7e-07, bitscore:
                     31.3, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLRTVETQRHITVRAHDGLRLAATLVTPATTARRAVLMLHGEGA
                     TREQDGFYPRLASDLAGRGATSLRLDLPGHGESEGRQEELSLSGLLNIIGAGLAHLREN
                     VPDTSVALVATGLTGGVAAGYAARKGPEVDRLVLLNPLIDYKEHFVDAQPAWTGDFLDE
                     PAARTLSADGRLALSPTFAVGRAMLNEVFWLQPRGVLGMIAAPTLIVHGAGPTDVPVES
                     SRAAADALTCSHRLVEITGPQRDYWQAPVIRVATDWIIADN"
     aSDomain        complement(19101..19499)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS09575_Abhydrolase_1.1"
                     /evalue="7.60E-13"
                     /label="JJ691_RS09575_Abhydrolase_1.1"
                     /locus_tag="JJ691_RS09575"
                     /protein_end="168"
                     /protein_start="35"
                     /score="40.6"
                     /tool="antismash"
                     /translation="AVLMLHGEGATREQDGFYPRLASDLAGRGATSLRLDLPGHGESEG
                     RQEELSLSGLLNIIGAGLAHLRENVPDTSVALVATGLTGGVAAGYAARKGPEVDRLVLL
                     NPLIDYKEHFVDAQPAWTGDFLDEPAART"
     misc_feature    complement(19598..19608)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: strong, score: 22.05"
                     /tool="antismash"
     gene            19832..21343
                     /locus_tag="JJ691_RS09580"
                     /old_locus_tag="JJ691_19110"
     CDS             19832..21343
                     /EC_number="1.-.-.-"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013739.4"
                     /locus_tag="JJ691_RS09580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19110"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_211768422.1"
                     /transl_table=11
                     /translation="MHTNLLPADAARWRTRRNPKRVTVIGAGVAGLVAAYELERLGHSV
                     EVLESRLWVGGRVRTHGFAGRARGPLAELGAMRIPASHHRTMQWIDRLGLSDRVRQFRT
                     LFSDDGNFLETPAGHRRVRDASPVLVEEFRRRLPADRSYRDESVLCAAWLTASVNAVAP
                     GAFQQNLHADLNLELLDLLDGIDVRPFLVDGAAERVDLNRFLANNAGFAARSRLQHFFD
                     DITTETSSELSRLEGGMDQIARRLADRLRGPVHHGRKVVGLHVRDDGVVVETRRGLATA
                     ASHCDYVLCTVPFSVLRGIRLTGFDDAKLAAVHDMQYWPATKIAVHCREAFWERDGISG
                     GGSYTGGLVGQTYYPPVESDPLLGAALLASYRIGPEPDALVKVPREKRTRVVLDELSVI
                     HPQLTEPGMVLDVVTQAWGEDAASLGGASVRWSKDIVTAEEERALAAQPQGTLFFAGEH
                     CSSYPAWIEGAIESGLAAAQEIHACAPVAQPVRSHGYRRIPGGAA"
     gene            21369..22979
                     /locus_tag="JJ691_RS09585"
                     /old_locus_tag="JJ691_19120"
     CDS             21369..22979
                     /GO_function="GO:0071949 - FAD binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000070: Oxidation (60% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF004780.0"
                     /locus_tag="JJ691_RS09585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_19120"
                     /product="FAD-dependent monooxygenase"
                     /protein_id="WP_211768423.1"
                     /transl_table=11
                     /translation="MSSLLTTEVLVVGGGPTGMAMGLELRSRGVSFVLVEAGDGAVGHP
                     RVSGIGPRSMEFFRRWGIADRIRHAGWPGDHPLDCVWTTRIGGHELFRLDRHTMDTRPE
                     FRHTPEPDAICPQHWLGPLLRSELGEHPDGPVRMRTQLDDFTQDADGVTATITDLETGA
                     VTTVRAQCLIACDGTGSEIRKQCGIGAPARHETQVFRNILFRAPELRERLGERNANFFY
                     LMISSALRFPVRALDGAGLYRLTVGLQGDPESRQDAETLVRAAIAFETPVEVLSDNEWH
                     LVHRVADTFRHGRVFLVGDAAHTLSPSGGFGMNTGICGAADLGWKLAAELGGWAGPGLL
                     GSYTTERKPVALEGLEEANRNLERAMRRQIPAELNDDTPEGEFVRAKISEGLRRGGVAR
                     EFDAPEIHLGFTYAGSPLIVPDPTAENTEDRRPNTRPGSRAPHAWVKPGMSTLDLFGDG
                     FVLLCFAESDRTAAFTDAFGSRGIPFSVVVLDNEEIAKVYERPFVLVRPDGHVAWRGHS
                     LPAPAAAGEIADQVRGGAR"
ORIGIN
        1 gccgtaccgc ctcctccacg gtcgcgagcg catcatcgat ccggccgtcg caccagctgg
       61 ccatcgcccg cacgttcaac gccgcggccc ggacgtcgtc gcagtgtgcg ccggggaccg
      121 ccagcacccg gtcggcgagt ccgatcacgg cggcccggtt gttgtgggac aacgcgttca
      181 acagcaacag gcttggcggc agatcggcgc cgtcgacgga acccgtgccg aagatctcct
      241 gcgacacgtc ccacgtggag gagtcgccgc ggagcatcag cgcggtggcc agccagatgc
      301 gcagcgggcg catcgccgac gggtggccgt tctccggcag caacgctcgc gcgaggtcga
      361 tggccctggt cagctcaccc agccggacca gcgccgcggt cgccgtgatc gccagcgcga
      421 tgtggtccgg gccggccggc tccgtgatct ccatgccacg ggtggccagc gccgcggcgg
      481 cgtgcggcga ggcggggagc agccgctggg cggcctcgcg gatggtggcg atggcgtgcg
      541 cgtcgccggt ctcggcacag tgcaccaggt gcaccgcggc ggcctcgggc cggtcctcgc
      601 cgcgtccgag cagcatcgtg gcggcctgcc ggtgcaacat cgaccgcagt ggttcgggca
      661 cggtgtcgag caccgcttgc cacaccggtt cgcggtggaa ggcgaactcc ccgccgccgc
      721 agctgagcag cctcgagtcc agcgcctccc gcagcggtcc cagcagttgg gcgggcggct
      781 cgttcagcat ctcggcgagg tcggtcgggg cgaagccgcg gccgagcacc gcggcgacct
      841 gcaacacgtc ctgggcccgt gacgagagct cactgaggcg gccgcgcaca acctggagca
      901 atggccgcgg cagctgcgcg ccgggctcgg cgacgacagc gcaggggatg cccgaggtca
      961 gcggccccga gacgagccgc gcgccgcggt cgtcgacggt gatcaagccc tgctcccgga
     1021 gcccgagcgc caggtcgacg atggcctgcg gggtgccgcc gacgctttcg cagatcatga
     1081 ccaggtcgtc gtccggaacc gcgccgagca ggtcgccgac gatgtcgacg acggcatcgc
     1141 cggacaacgg ctcgagcggc ccgagccact cgcttcggca ggtccgcgcc aggttccgca
     1201 gccacaggcc gttggccgac tccgcgtgct cggcacgtag cgcgaacagc cagagcaccg
     1261 gtgcgtcgtc cagcctggat gtcagcgcgc cgacggcgcg cagcatcgcc gggtcggtcc
     1321 actgcacgtc gtccagcacc accagcaccg ggccgcggcg caggtgcccg tcgagccagc
     1381 tgatctggtc gttgtcgtgg cggccgtggc gagggccgac cgtggtgagc gacttcggcg
     1441 cgccgtcgag caccgtgaag ccgctctgcg cggccaacga catcgcttcg aggagcagcc
     1501 tggtcttgcc ggtgccggcg ccggagacca gcagcgccag gtgtccctgg tgctgctcgg
     1561 tcgtctcgcg catcagccgc ttgatgcggc ggatcggctc gtcatggccg cgcagcggcc
     1621 acgcggccga ggccggcggt tccgtgagct tctcgagagc ccgttgcacg aactgccccc
     1681 agtcgtggtg attcatctct cggtcacgtg gtgttattca attttattgg tggatcgggc
     1741 gcggcgtccg cccgattatc gtcatagctg ttgtcggtat ggctccacca cctcgaaaaa
     1801 actacggtac gcgtgattgg tgggtcaagc tcgcgtcaac tgtcgacggc gtgcgggcat
     1861 cgatccttgc acggtcttac actcatcgga ttgcattccg ccgccgtggc cgatcgtgcc
     1921 cgttatcggc cttttcgatc atcatcggcg ttggaatcgg cgctgtgcgg cgccttcgtg
     1981 gccgcgaact ccccgttgac ctgcgccgct ccgttcatcc cgcatcgacg aatcggaaag
     2041 tgtatacaca tcgcacgtga aaaacgggcg ccgcggtgga tggccgccgc gctcggattc
     2101 gcgattccgg tgttacggca atcggcgcag tcgatgatca tgttggcttc ggtgatccgc
     2161 tgacgagttc gccgtgcgcc gctcggaatg tctatgcgtc accgtgcatg cccaattgcc
     2221 gacctgtgtc gagccggacc ggccgatgtt ccccgaaggc gcgtgcccgc agcgtctgct
     2281 ggatgcgggg gcatcggctg gtccaccgcg gacagcggac acgaccctcg gcggcaccgg
     2341 gtcgccacgg tgggccgagt tctgtccgaa cggtggtgtc acctcggaca gaactcggcc
     2401 tgctgtaacg ggatctctgg ttgtgcgatc gccgccgccc gcgtcgcgaa cacggtgggc
     2461 gagctcgcca tacggcgggt tcggctacca ggaaaccgga agtgagcgaa cgccgtacac
     2521 caccatgtcg tgcttgaact gcacctcgtc gaacggaatc gccagtttca gcgtcgggat
     2581 ccgtcggtac agcgtgccgc agacgacctg cagctccatc cgggccagca actggccgag
     2641 gcactggtgg gagccgtagc cgaaagccac atgttggcgg ccttttcgct ggaggtcgag
     2701 cgtgtccgga gccgggaaca ccgactcgtc ccggttgctg gccccgtcgg cgagaatgac
     2761 cccttcgccc gccttcacca actggcccgc gagttcgacg tcctcggtgg cgacgcgccg
     2821 ccgtccgacg tgcacgacgc tgaggtagcg caacagttcg tcgacggcgc cggcgatctc
     2881 cttcgggtcg tcggcgtccc gcagggcggc gagctggtcc ggatgccgca gcagggccaa
     2941 cgtgcccagc gcgatcatgt tcgcggtcga ctcatggccg gcgaccagca tcagcagggc
     3001 catttcggcg atctccgcgc ggctcaggtt gcccggccgc agctgttcgg ccaccagcct
     3061 ggaaatcatg tcgtcgccag gctcggtgtc cttggcgtcg accagcttga gcatgtactc
     3121 ctgcagcgcc acatgcgctt cgagcgtttc ctccacggtg cacgactggg agaagagctt
     3181 cctgctgcag tcctggaaga agtcgtggcc gtcgtaggga acgccgagaa gttcgcagat
     3241 caccagtgac ggcaccggca acgcgaacgc cgccaccagg tcgaccggat tcggtccggc
     3301 gagcaggtcg tcgatcagtc cgtccacgat ctgcgcaacc ctggggcgca tggcctcgac
     3361 gcttttcagg gtgaagttct tgctcagcat gcggcgctgc gcgccgtgct ccggctcgtc
     3421 catcatgatc agcgaccgga aatcgtggat ccgctcggcg acggcggcgg actcggcggg
     3481 gtagccgtcc cggcgcgcgt cggcgctgaa cctctggtcg gacagcacga atcgatgcgc
     3541 ctcgtatccg gtcaccaccc acggcgtgct gccgtcccag attcggaccc ggccgatcgg
     3601 ccccatttcg cgcagaccgg gtggtgggtc gaacggacac tcggtggccc gctgcatcgg
     3661 gtagaaagga acagtttcca ttaccgcact tcctggtcag aactccggcg tctgcgggtg
     3721 gaggatgacg gctctcgcgc ctcagtgagg tcagatgcga cggattcgcg caagccacgc
     3781 cgcgaggtcg atcgggccgt gtgcgggcag accggcgttt gtcgctgtct cggctatctg
     3841 ctcggtgacg taaccctgat aacgagccgg ctgtaggtct tccagttccc agccgtcgtc
     3901 gaaggattcg cggatcaccg catcgctgat ctgtgaactg aggcccggct cggcgtccga
     3961 gtgtgcgaga atatggacca ggccgcccgg gttgcagatc gagtgcagca ccttcgcata
     4021 cgctttgggt gtccccatgt ctcggccata cgcgccgaag ccgtggaaca gcgcgcagtc
     4081 gacgatcgtg tcgaaggccg gtgtgagcgc ggagtgatcg ccggggtgga gcatgttggc
     4141 cacctcgaac cgggcgttgg gcaccccctt ctcggcggct gtgcggcgag cgtacgccac
     4201 ggcgctgggg gagaggtcga caccgatcgc gtcgtagccg agcttggtga acagaatggt
     4261 gtgttccccc gagccgcagc ccggttccag cacccgaccg cgaatcagcc cttcgcgttc
     4321 gagcgcgacg atcgccggct gcggctcgcc gataagccag ggcgcggtgt tgttgtcgta
     4381 catggaattc cagaattctg gattctcgaa cccggtagcc aagaattctg gattctctaa
     4441 cccggtaggc tcggtcatga ctccagtctc gcctatcgaa ccgacccgag ggttcgcgtg
     4501 ggatgaatcc tgttgcgttg tgcggggtgg aaaaccgtcg acgggtgcga ctgcgtgggt
     4561 acgggcgtcg ccatgacccg cgggtgaggg gctgcgagca gcttgcgcat gtccgtgggg
     4621 tcagcccacc agttcgacga gtcggggcac gagatcggcc ggcgccggct gggcggcgat
     4681 ctcggccttg acctcggcgg ccgcggtcgc cagcgaggcg tcggtcagca atcgcgtcac
     4741 gtcgttggcg tcgacggggg ccaccgcggt gtcgacctcg aagccgacgc cgcgcttggt
     4801 cacctcgcgg gcgttgtgga actggtccga gccctgcggc acgaccagct gcggcacacc
     4861 catcgccagc gacgtcatgg tggagccagc gccgccatgg tggaccaccg cggtgctggt
     4921 ggccagcagc gcgttcaacg gcgtgtacga caccggccgc acgttgtccg gcagcgcgcc
     4981 gaactgcccg gcctcggcgt tgtcgagcgt gacgacgaac tccgcgtcga agccgccggc
     5041 cacgtcggcc agccactgca acgggccgag ccccacgagg ccggggatca ccgtgccgat
     5101 tgtgacgatc acccgcggcc ggtccggccg gtgcagcagc cagtccggca gctggccacc
     5161 gccgttgaac ggcacgtacc gcatcgccca acccagatcg ggcgtcccca tgctcggcgg
     5221 cgccacgttg agcagggcgt gccgcgtggg cgggccgtcg actccgtgcc ggcggtaggt
     5281 gtcggtaaga gcctcggcga cctgcgtgac ctggtcctcg gcgctgagca ggccgtaagc
     5341 ctgttcgacc gcgggcacgc cgagcttggc cgcggccagc gggccggcgc cgtctatcgg
     5401 cgagtgcacc accaggtcgg gccgccactc gtcggcgatc gccaccacgg tgtcggcgac
     5461 gaggtccgac tgcggggcga acacctgcgc gccgaagccg atcagccgct cgacgtcgcg
     5521 ggacgcctcg cggatcatct gctgcaccgc ctggatgtcc atgctggcgt gggccgcgtc
     5581 gatcagccgc acgaccgact cgtacggctg tgtctccacg acgtgcaggc cggacgcggc
     5641 cagcgttggc acgtgctgtg caccgctgcc ggccatggcg agcagcacct cgtggcccgc
     5701 ggcgcgcagc gcccaggaga tcgacaccat cggcagcatg tggccgaggc cgggcgaagc
     5761 cgtgacgaga accctcatca gaacccccgg tgcggaaagc tcgctgcccc gctcgcacca
     5821 gcagtcgcgg caggttccgc gatgccgcgg gcgaggtcgg agatgcgttc tgccgcggcg
     5881 agcgtgggga agtgtgtgtt ggcgcggggg atctccggga aaacggacgc gtcggcgacc
     5941 cacagcccgt ccacgcccag cacgcggccg gtgggatcga cgacggtccg cgcgtcgtcg
     6001 ggcgatccca tgcgacaggt gccgctgagg tgcgcggcgt cgcccacggt ctcaagcagc
     6061 cagcggtcga tctcggcgtc gtcggccagc gagtcgagcc cccggcccat cggatctatc
     6121 gcgacatgac ggatcacctc ggcgaatggt ggggtggcga ccagttcgcg aacgcgccgg
     6181 acgccctcgc gcagacgcac caggtcggat gcctctccga gcatgttgtg ctcgattcgc
     6241 ggcggggcat cgggatcgtc cgaggcgagc acgagtcgcc ctcgcgagac gacctggttc
     6301 tcgaccagcg ccaacaaact cgggtcagtg ctcggacgga cttctggctg gtgatcgtgg
     6361 ttgtcgccga ggccgactcc ccaggtaccc gtcgcttcct gagcgggagc atcgccctcg
     6421 acgcccagcg acgtcatcgc gggcggacgg ttcatgtgga tcatcatcaa gtcgttctcg
     6481 cccgcgaggc ccgacgaata gcgaacgcag cagttgtact gacggctgtc gatgccggcg
     6541 ggatgcgcct ccggctgcaa gtcaagccag aacagcgcca gcggatggtc ctggaggccg
     6601 tccccgaccg ggagatccgc cacctctttc ccgggcccga tgccggaccg caacaggatc
     6661 gccggcgagt ggatcgcccc cgcgcacagg acgacagccc caccgcggac gtcgatccgc
     6721 tcctcgccga cgcgcacccg tacgcccgtt gtccgatggc cgtccagcaa cacgcgctca
     6781 acggtggcgt cgccgacgat ctggaggttc gcccgctcgc gcaccggttc gaggtaagcg
     6841 tcgttggtcg tgacacgcgc cccgtcacgc acactgagcg cgatcggcga cacaccggtc
     6901 ccggtcggcg cgttgtagtc ctcgcaccac gggtatccga ggtcgagcgt ggcgacggcg
     6961 aagcgatcgt cgaggagctc ccaccgctcg cgtgggaggc gctcgaccgg catgggcccg
     7021 tcgctgccgt ggtaggtctg gttgccgaag tcggcgtcag cctccatgcg acgcaggtag
     7081 ggcagcatgt cttggtagga ccagccgtcg cagccggctg ccgcccaccg gtcgtagtcg
     7141 tcgggccgcg cgtggatggc catcatgccg ttgatcagcg aggagccccc gaggccacgg
     7201 ccgcgcaggt aggggcgcgt ggcttggtgt ggggtccgga gtgcttcgag gccgggccag
     7261 tagaagcggc ggcactcggc ggagtcaagc ggccgccagc cgttgagact gcggatttcg
     7321 cgcggggccg ccgacgatcg ccagtccggt cctgcttcga gcaggatgac tcgcttgctc
     7381 gcgtcttcgc tgagccgact ggccagcaca cagccggcgg ggccgccgcc gaccacgatc
     7441 cagtcagctt caagggactt caccgcggac tctcctctct ccgaattcag cgcggcacgc
     7501 gggctttggt cagcacggtg tccaggtacg tgatgagcgg gtccacagac gagggagcgg
     7561 caagcgcggc gatgtgcccg tctggtcgca ccagcaccag gcgtggaccg tccacctgat
     7621 aggcccggta cgccgcgtgc tcaccggccg ggatcacgtg agtggtgacg gacgcgtggt
     7681 agcgggcagt gagctgggac gcgagttcgt cggtgtccgt gttgtcggcg gagaacacca
     7741 gcaagtggta gcccgcgcca tgggtcaggt ccaggacgct gcgcgcgccg tcacgggtgg
     7801 actcgatggg ggcgaaaggg gcgcggtcgc cgggtttcag ggcgccgacg ccgggaccga
     7861 ccgcgcggct gccgcggtag ttgatccaca actgcgagaa catgtggaag accagccggc
     7921 gcaccggggc cagccggctg accacgccga cgacgcgggt ggccacgttg gcccgcatcc
     7981 aggtggccac gggattgtcg gtggtctcca gcttgaatcc cacgtcggtg cgcttcagca
     8041 cggtttcggc gatcggccgg cgctcggact cgtaggtgtc cagcagccac tccggggcct
     8101 cgccgttgac gacctgcgcg agtttccacg cgaggttgac cgcgtcgccg atcccgaggt
     8161 tgaggccctg gccgccggcc gggttgtgga tgtgcgcggc gtcgccgacc aggaacgcgt
     8221 tgccgacccg gaaccgggcg gcaagccggc tgtggaagcg gaacatcgag gcccagctga
     8281 cctcgcggag gttggcgtcc acggtgaagt agtcgtcgaa ccagcgctga aggtcggcgt
     8341 gggccagcgg ggcgtacgac tcgtgcgacg gcccgccgcg ctgtgcgggc gcctggtgca
     8401 gctcgggcgg caccacgccg aacagccggc agcggccgct ggccagcgga aggatgccga
     8461 cgaagccgcc gcgggtgagg ctcagtcgca tgccctggac gcccagctcg acgtccagag
     8521 tgacgtcggc gagcatgccg gcctgctcgt aggtctcgcc ctcgaactcc tggccgagga
     8581 tccgtcggat ggtgctgctc gcgccgtccg cgccgacgag ccagcgcgcg gtgatcgtgg
     8641 tggggccggc ctcggcggcg agttggacgc gcacgccgtc gccggtgtcg gtcaggtccc
     8701 gcacctcgca gttccatccg acggcgactt cgtgctccgc caaggcttcc gccagcaatc
     8761 gttcggtctc gaactgttcg agggcgagcg cgtaggggaa gcgggtctgg tcggtggtgc
     8821 ccttgccggc cagcggcatg tcgccggcgt gccgcccgcc ttcgtggatc gccacgttcg
     8881 tgatgagccg gccccgagcc accgccgcgt ccgcgacgcc gagccggtcg aggtactcca
     8941 gggtccgcgc gtgcacgatg gcggcccgcg cctgctcgac cggcccggcc ttgcggtcga
     9001 cgatccggac gcgcacgccc tgctgcgcca gcacaagcgc ggcgcacagg ccggtcgggc
     9061 ccgcccccac cacgaggacg tcgcagtcgt gttcgtcgcg catcggcagt ccccgttcgc
     9121 atcgatcaac ttcggtgtga gcgagtatcg cgactgggcg gcacgcgcca catcgcccgg
     9181 cgcggtgcgt gctgcggcga tcaccccacg cgagtgcgca ggttctccca ccggcccctt
     9241 ttgggcccgg ccgggcgggc tcgatggtgg cacctgacca cgcatcgacc gctacgaatc
     9301 cggggactgc catgaccgct gcggaaccgt acttcgacga cctggccgag ctctacgagc
     9361 ggttcaccca ggtccgggac gccgcgacga gtccggtgcg gtcgtggctc accgcacagc
     9421 tgtcgaccgg ggcccgggcg atcgacgtcg gctgcggcgg cggcaacaac tgcggcctgc
     9481 tcgccgatcg ctacgacgag gtggtcggcg tggacatctc gcagaagatg ctggacatcg
     9541 ccagcaccaa gccgacgcgg gtgccggtgc gctacgagtg ccgcagcgcc accgatctga
     9601 cgcccgaccg ggacgggcag ttcgacctgg tgatgtcggt gaacgcggtg ttccacatgg
     9661 gaccggccga ggtcgtgctg ccgacgctgc gcgacctggt ggcgcccggc ggccggctgg
     9721 tgatcatcga tgtgacccag ccggacgacg gggccgagcc gcgcgagcag agcgcctacg
     9781 cgttcgagac cgggaagatc gtttatgacg tctccggcga cgtggcggcg gcggtggact
     9841 cgatccggat gatgctgcac ccgcgctggc tggagatgag cgcgcaggcg gcgccgctgt
     9901 ccgagaccga gttcacggtc cagtacgaga aggcgctgcc gggcgtgcgc atcaccaaga
     9961 acgtcatccc caccatgagc gcggctgtct gggacgcggc gtgagcgtgt tcgacctgcc
    10021 gcgggtgcac ttcgccggcg tggccgtcac ccggctgccg actggtccgc gcgcgggact
    10081 gctcgacctg gagaccaacc gggcggtgac cgacgacggg gtgttcgaca ccgcccgccc
    10141 cgcgcgggag taccacgagt tcctggcggc caagggggtc gagggaacga acttcgccgg
    10201 caacggccac ttctggatcg acgcggcggt cgtcggctgc gagcgggcgc cgggcgtggt
    10261 cgacgtcgag gacctgttgg tggggcggca gctcgacctg tggggccact actacgaata
    10321 caccgccggg accgcgaacc ggtcgcgtgt cttcgacgtg gacccggcct cgaactggac
    10381 gaccacggtc atggtgggcc agctcgcgct cggccggctc ggccgttccc acgaggtcgg
    10441 ctacctggtc accggggacg tctccgggat gtgcccgccg cgctggcaga acaccgcgta
    10501 cgtccgggac gacggcgtcg atccccggtt ccggcggtcg gtgctgcacc agttcgtggt
    10561 ggaccgggcg gagggtctgc actggctgtc cggcgcggag gactcgccca cgttggcgcg
    10621 cctacgcgaa ctggtcgagt ccggcgcggc cgacgggttg gtcgtgcagt tcgcgctcac
    10681 caacatggcc acgcccaccg ccgacggcga gccggacttc tgggacctgc gcggcacgat
    10741 cgccccctgg cacgggacag aactgcgcac ctacccggtc ggccggctgc tcaccccgcg
    10801 cgctgccgcg aattcggctt tgcacaacct gtccgtgcac gtcggagacg acgtcgtcac
    10861 cgcgaatctg gtcagcgcga tcccggtgac cagtcgggcc gacacccgtg gtcccggtcc
    10921 gacacaccgg ctcgggccgt tcatcgacct cggcgatctc gacgttcgga ccagttcggg
    10981 cacggtgctc gcgaccattc cccgtgccgc ctatctcggc gatgcgtatc ggctcacctc
    11041 gggtgtgctt gtggcgcaac gggtcgacgg tggcaccggc aatcccggcg aagccttgat
    11101 gatcaccgca gccgacggca ccgtgctggc ccgcgaggag gagacggtcg tcgagtccga
    11161 cgaggcgtcg ctgttcctcg aacacgagaa cccgaagacg ggggaggacc acgcggtcga
    11221 gatccccatc cgctcatacg tgcgcggtga accgggccgc gtggaccgca tcctagtgcg
    11281 gcagtacgtc aacccgcgcg ggcggccgct cgacgacgac cacgagcagg tgagaatcgc
    11341 ggagtttctg gttgctgggc aacaggacta ccggcccgac tgcgtggcgt cgaccgacga
    11401 gcacgggcgg ggcgcgatcg cgatcaaggg aattcgcggc ggtgcggcca agatcctgct
    11461 gctgcccgac gggcaggatc tgccgcgtgg ggtgaatacc gccgagcgct acgacaacga
    11521 cgacgagcag ggctactggt cggcggtcgg cagcgtggcg ctgcgggtgc tgcccaacca
    11581 ctggcacctc gacgacctgc cggacaacga gatcaccttc cccacgctct accgcgaggc
    11641 gctggcgtat tacgagctcc agtactcgtt catgcgggcc gaggtgttca gcctggccga
    11701 cgagttcaag gtcgagccgt acgcgcggct gatgtgccac gcctccgaac ccgagcgcaa
    11761 gtccaagacg tactacatgc cgccgacccg tgacatgagc gcaccgcagg ttcgcctgat
    11821 gcggcgctac ctgctggccg acgaggcgcg gcggcagacc ccgccgacga tggtgccgca
    11881 gcaccgcaag ctcggcgtga tcaccaccaa ggagcagctg ctgcacgcgt tgtaccaggc
    11941 ggcggccatc gaactggcca cgatgatcca gtatctctac gcggcgtact cggtgccgct
    12001 ccacagcgcg ggccggcagt acgtggctcg cggcgagtgg accccggagc aactgctcat
    12061 cgcctgcggt gacggcacgc agtcgtggaa gaacggcatc cgcggcaacc tgatgtgcgt
    12121 cgcccgcgag gagatgatgc atttcctgac catcaacaac atcctgatgg cgatgggccg
    12181 gccgttccac ctgccgcggc tggacttcgg cgagttcaac agcaaggtct gcgtgccgct
    12241 ggagttctcg ctggaggcgc tcaacctggc cagtgtgcag cgtttcatcg aactggagca
    12301 gccgcacgac ctgatcgacg aggtcgaggg caacgactcg acggtgctgc ggccggacgg
    12361 cgagccgtac cggtacgggt cgttgagcga gctgtacgcg gcgatccgcg agggcatcca
    12421 ggcggtgccc ggcgtgttcc tggtgaagaa gggccgggcc ggcggcgcgc accacctgtt
    12481 catgcgcgag tcggtcaacg ccgtgcatcc ggactaccag ctggaggtcg acgacgtcgc
    12541 cagcgcggtg ttcgccatcg acttcgtcac cgagcacggc gagggcggcc atatcccgtc
    12601 cacgctgccg gccgaggaat cgcacttcga caccttcctg cgcatctgcg atctgctggt
    12661 gcacgagcgg gccaccggcc ccaacgaccg ccggatcccg tggcacccgg cctacccggt
    12721 gctgcgcaat cccacgctgc gacccggaaa tccgacgatg gacctggtca cgcacgagcc
    12781 tgcccggctg gcgatgacgg tgttcaaccg ctcgtacttc atggcgatgc aactgatggt
    12841 gcagcacttc ggccacagct ccgacaagag cctgcggcgc tcgcggctga tgaactgggc
    12901 actggacatc atgaccggcg tgctgcgccc cctcggcgag ctgatcgtca cgctgccgtc
    12961 gggccgtccc ggccgcaccg ccggcccgtc cttcgagctc gacgaggagc ccgtctacat
    13021 cccacgcccg gacatcgccg tggagtggat ggcgcgcgag ttcgacgaga tcgccgtgct
    13081 ggcccgcaag tgcgcgggtc tcaccccgac cgtcgcggac ctgctggcgt tcctcggcga
    13141 gcagctgcgg gcgatggacc tcaaggaact gtgatgacca gaacgaagaa caccacggtc
    13201 tgcgtggccg gcggcggtcc ggccggcgcg atgctggggt tgctgctggc ccggtccggt
    13261 gtggacgtcg tggtgctgga gaagcacgcc gacttccacc gcgacttccg cggcgacacc
    13321 gtgcacccgg cgacgctgca gatcctggac gaaatcggcc tggtggaccg gttccacgag
    13381 ctgccgcacc agaaggtccc gacgatcggc gtggtgcagg acggccggcg catcgacatc
    13441 gccgacttcc gccggctgcg ggtgcgctat ccgtacatgg ccttcgtgcc gcagtgggac
    13501 ttcctcgacc tgatcaccgc cgaagccgcc cggtatcccg ctttccggct gatgatgcgc
    13561 accgaggcgg tggacgtgct gcgggacggc ggccgcgtcg tcggcgtgcg ggcgcgcggg
    13621 ccggagggcg agctcgacat ccggtccacg gtggtcgtcg ccgcagacgg gcggcactcg
    13681 gcgatccgcc gcgccgtcgg cgtgacgccc cggctgatcg gccgctcgct ggacgtgatc
    13741 ttcttccgga tctcgcgccg ggacaccgat ccggacgagg gcatctgcgt gcgcatcggc
    13801 aacggcaaga tattcggcgc caccgatcgc cgcacctact ggcagatgtc gtacgagacc
    13861 accgcgggcg gcatggcgaa ggtgatcgcc gccgggctcg acgccttccg ggccgatctc
    13921 gccgcgatgg tgccgttcct ggccgaccgt gtgcacgaag tggcctccta cgaggatctg
    13981 agcctgctgg aggctcgcat cgaccggctg gaccggtggc accagcccgg tttgctgttc
    14041 atcggcgacg cggcgcacgc gatgtctccg gtcgcggggt tcggcgtgaa cctcgcggtg
    14101 caggacgcgg tcgccacggc caacgcgctc gtcgccccgc tgctgcgggc gcagcgaacc
    14161 ggcgccgcgt tcgaccactc gcggctggcc gcgatccaac ggcgccggcg cctggccacc
    14221 gccctgtccc agggactgca acgggcgacc cagcgcttcg gcatcgacga cgccctcaac
    14281 ggttcgggcc agccacccgc acccaagttg ttcgagaagc tcgcccccgc gcagtggttg
    14341 atgagccgga tcatcgggct cggcttccga cccgagcacg tgcgcacccc ggccgccagt
    14401 ccggcgcaga ccgaagggac ccgaggatga ccccgcacca gcggatgatg tcgatgatca
    14461 ccggctactg ggtgacccag atcgtgcacg ccgtcgccga gttgggcatc gccgaccatc
    14521 tggcggacgg cccgcgcacc tcagccgagc tggcggagct cactggctgc gaccccgacg
    14581 cgatgtcccg gctgctgcgg gcgtgcgccg cgcaggaact ggtcggcgtt cggtccgacg
    14641 gcacgttcga gacgacaccg atgctggcgc tgctgtccga aggcgtgccg cactcgttcc
    14701 gcgacatcgc aatcgtgcac ggctcgccgg ggcactggct gtcctggggc cggttgccgg
    14761 acgcggtgcg ggccggcgag ccgcagacca aggccgcact gggcatggac atctgggacc
    14821 acttcgccga caaccccgtc gagcacggcc ggttcgtcaa ctccatgacc gaactcaccg
    14881 cggggctgtc cgaggagatc gccgggctgc tggacgtcac cggcgtcggt gtcgcggtgg
    14941 acgtgggcgg cgcgaacggc gcgttgctgc acgcggtgct gcggtccaat gccgagatgc
    15001 gggggttgtt gctggacctg cccgccgtca cggcgacggc gactgccgag gcggcgaagg
    15061 ccgggttgag cgaccgggtc acggtggtcg gcggctcgtt cttcgatccg atcccggccg
    15121 gcgatctgtt cctgctcaag gcggtgctgc acaactggga cgacgaggcc tgcgtgcgca
    15181 tcctgagcaa ctgccgagcc gcgctgaatc ccggcggccg ggtcgtggtg gtggagatgc
    15241 cgctgggccc gatgggcgaa cccggcttcg ccccgctgct ggacctgaac atgctcgccg
    15301 tggtgtccgg ccgggaacgc gacctcgacc actacgacga cctgttcgcc gcggccggac
    15361 tgcggcggac ccggatgacg ccgacccgct cgccgcagtg cctgatcgag gcggtcacgg
    15421 cgtgaccggc tcactgacac cgaccaacgg aggatcttga tggtgaagca tgttgtggtc
    15481 gtcggcggcg gcaccgcggg gtggatgacc gcatcgtacc tgaccgcggc gttcggcgac
    15541 cgggtctcgg tgaccgtggt ggagtccgag cgcatcggcg cgatcggcgt cggcgaggcc
    15601 acgttcagca cggtgcgcca cttcttcacc tatctggggt tggaggagaa ggactggatg
    15661 ccggcgtgca acgccaccta caagctggcg atccggttcg agaactggcg ggagcccgga
    15721 caccacttct accacccgtt cgaacggcag cgcgtcgtcg acgggttcac cctgcccgac
    15781 tggtggctga gcgcgccggc gtcggaccgt ttcgacaggg actgcttcct cgtcggcacg
    15841 ctgtgcgaca acctcaagtc cccgcgccgc atggacgggg cgctgttcga gggtgacctg
    15901 tccggggacc ggtccactta ccggaccacg ttgtcggagc agtcgacaca gttcccctac
    15961 gcctaccact tcgacgccac gctgctcgcg aactacctgc gggactacgc gatggcgcgg
    16021 ggcgtgcggc acgtcgtgga cgacgtggtg cacgtggcac aggacgagcg cggctggctc
    16081 agccacgtca ccaccaagca gagcggcgac ctcgccggcg acctgttcgt ggactgcacc
    16141 ggcttccgca gcatcctgct gggcaagacg ctggcggagc cgttcgtgtc ctatcaggac
    16201 actctgccca acgacagcgc ggtggccctg cgggtgccgc tggacatggc gcacaagggc
    16261 ctgcggccgt gcaccaccgc caccgctcag gaggccggct ggatctggac gatcccgctg
    16321 ttcgaccgca tcggcaccgg ctatgtctac gccagtgact acagcacacc cgagcaggcc
    16381 gagcagcggc tgcgggagtt cgtcggcccg gcggccgagg acctgccggc caaccacatc
    16441 aagatgcgca tcggccgcag ccgccggcac tgggtgcgca actgcgtcgc gatcgggctg
    16501 tccagcggct tcgtcgagcc gctggagtcg accggcatct tcttcatcca gaacggcatc
    16561 gagcagctgg tgaagcactt cccggacgcg gactgggacg aggggctgcg cgactcgtac
    16621 aaccagctga tcagccgatg catggacggc gtgcgggagt tcctcgtcct gcactactac
    16681 gcggccaggc ggcgggacaa ccagtactgg caggacgcga agaagcgccc gctgccggac
    16741 gggctggccg agcggatcga gcgctggcgc actcgcctgc ccgacgcgga gacggtctac
    16801 ccgcactacc acggattcga gtcgtactcg tacgtctgca tgctgctggg gctcggtggc
    16861 atcgacctca agtcctcgcc cgcgctggcc ctgttggacc cgtcgtcggc ccggcacgag
    16921 ctcaagctcg tcgccgagca ggccgccgag ctcgaacgca cgctgcccac ccagtacgag
    16981 tacttcgccc agttccgctg acggagagcg atcatggtcc tgcagaacgt cctacaactg
    17041 ctcgcgctgc tgggcgcgct ctgcgtcgcg gccgcggtcg ggcggctgct ggcccggctg
    17101 gcccggttgc cctcggtgat cggcgagatc gtcgtgagtc tgctgctcgg cccggcgctg
    17161 ctggccaccg ggggcccggc ggtgtacgcc gcggtgctgc cccaggatct cctcgcggtg
    17221 ctcaaggaga tcggtgaggc cggcctggtg ctgtacctgg tgggcctcgt ccaccggctc
    17281 gaccatgggc cgggcggctt gcgcggcagg ggagtccggc ggatcaccat cgggtcgctc
    17341 gggatcccgc tggtggccgg gctggcgttc gccggctggg tgctctggtt ggcgccgccg
    17401 gaactgcggg gccatgcgaa cgcgtccgca ctggtgctga tgctcgcggt gacgatgagc
    17461 gtgaccgcgg ttccggtgct ggcgcgcatc atcgaggaac gcaaggcggc cctcggccgc
    17521 tccgccgagc tggcgatgat ggcgtccatg ctgatcgaca ccctgtcgtg gctgctgctc
    17581 gcggtcgcgt tgggtctgcg gaccggtggc atcggcggtg tcctccaggc gttcgtggtg
    17641 ctggcggtcg gtggtgccat cgcctgggcg gcccaccggg gcctggccac cgcttggtcg
    17701 acgcggctgt gcgcgagcag tcctcgcctg gtcgcggtgg tgctcggcgc cgtcgcgatc
    17761 acggccggca cggggatacg gctggccgga ctgaccgcgg tcttcggcgc gttcctggtc
    17821 ggcatcatgg tgcccaggac cgagggctgg tcggtggtgg tgaggtggat cggccgcatc
    17881 ggccgggctc tggtcccggt gtacttcgtg gtcgccggca cgacggtgtt caccggcggc
    17941 gtggccgcgc tgccgtggct cgcggttgtg ttggcggtcg cgctcggcat cctcgggaag
    18001 gtcctcggcg gctacctcgg cgcccgctgg ggcggtgagg accggctgac ctcggtgcgg
    18061 atcggcgtgc tggtcaacac caggggactg accgagatcg tcgtgctcca ggtcggttac
    18121 accgccgggc tgctcacgcc gggactgttg gtggcgctgc tggtgatggc gctgctcacc
    18181 acggcgctga ccgggccgct gctcgatctc gtcgatcgcc gcacggccgc ggggaaagcg
    18241 cttccagtgg gcgagagcgc tgtccgatga ccatttccta cgcggccacc tcggccggat
    18301 tccgatcgct gatggcggga tttccgaccg gcgtcgcggt gatcactacg ttcggccccg
    18361 acggcgagcc gtggggcatg acgtgctcgt cggtgtgcag cgtctcggtg gaaccgccga
    18421 cgctgctggt gtgcgtgcgg gccggcagcc ccaccctcgc ggccatgctg cgccgcggtg
    18481 agttcaccgt caacctgctg caccacggcg cgcgtccggt ggcggagttg ttcgcgtccg
    18541 gcgatcccga ccggttcgac cgcgtcgact gggcggtgcc gccggtgtcg ggcggtcccc
    18601 acctggtgcg ggacgcgcac gcggtggccg actgccggat cagccgccgg cagcaggtcg
    18661 ccacgcatgt cgtggtcttc ggcgaggtcg tgcacgtcac gcagcggccg ggggagcacc
    18721 cgctgctgta cgggatgcgg cagtacgcgg cctggccggt cagctgaaca caggaacggc
    18781 gggggtgcgc gcacccccgc cgttgctggc tttcagttgt cagcgatgat ccagtcggtc
    18841 gccacccgga tcaccggagc ctgccagtaa tcgcgctgcg gaccggtgat ctccaccaac
    18901 cggtgcgagc aggtgagcgc gtcggcggcg gcgcgggagg actccaccgg cacgtcggtc
    18961 ggaccggcgc cgtgcacgat cagcgtcggc gcggcgatca tgcccagcac accgcgcggc
    19021 tggagccaga acacctcgtt gagcatggct cggccgactg cgaatgtcgg cgacagcgca
    19081 agccgcccgt cggccgacaa ggtccgggcc gccggctcgt cgaggaagtc gccggtccac
    19141 gcgggctgcg cgtcgacgaa gtgctccttg tagtcgatca gcggattgag cagcaccagc
    19201 cgatcgacct ctgggccctt gcgcgcggcg tagccggccg cgacgccacc ggtcagcccg
    19261 gtggcgacca gggcgaccga cgtgtccggg acgttctcac gcaggtgcgc cagtccggcg
    19321 ccgatgatgt tcagcagccc ggagaggctc agttcctcct ggcggccctc gctctcaccg
    19381 tgtccgggga ggtcgaggcg caggctggtc gcgccgcgcc cggccaggtc ggacgccagc
    19441 cgcgggtaga agccgtcctg ctcgcgcgtc gcgccttcgc cgtgcaacat cagcacggcc
    19501 cggcgggctg tcgtcgcggg cgtcaccagg gttgcggcca gccgcaggcc gtcgtgggcg
    19561 cgcaccgtga tgtggcgctg tgtttcgact gtgcgcagtg acatggcaca agagtcgccc
    19621 gtgtacagcg cgccggcacg tgtgcgtgcc ggattccatt gcctcgtgtg atgtcggcgg
    19681 cccgtccggc tggcgatcgc gtggcgcggg cgccacaaac actccatcgc gagcggcggc
    19741 tggggatgtg ggacggcccg tcggttggcc aggattggtc ccgccccgaa gcggtcagcc
    19801 gatcgacccc cgttctgccg aagggaatcc gttgcacacc aaccttctcc ccgccgacgc
    19861 ggcacggtgg cgcacgcggc ggaatccgaa acgggtcact gtcatcggcg cgggggtcgc
    19921 cggcctggtc gccgcgtacg agctggagcg gctcggacac agcgtcgagg tgctggaatc
    19981 gcgactgtgg gtcggtggcc gggtgcggac gcacggcttc gcggggcgcg ctcgcggccc
    20041 gctggccgag ttgggcgcga tgcgaattcc ggcgtcccac caccgaacga tgcagtggat
    20101 cgaccggctg ggcctgagtg accgcgtgcg ccagttccgc acgctgttct ccgacgacgg
    20161 caacttcctg gagacgccgg ccgggcaccg gcgggtgcgc gacgcgtcgc cggtgttggt
    20221 cgaggagttc cgccggcgcc tgccggccga ccggtcctat cgggacgagt ccgtcctgtg
    20281 cgcggcctgg ctgacggcca gcgtcaacgc ggtcgcgccc ggcgccttcc agcagaacct
    20341 gcacgccgac ctcaacctgg agttgctgga tctgctcgac ggcatcgacg tgcggccgtt
    20401 cctggtcgac ggcgccgccg aacgcgtcga cctcaaccga ttcctggcca acaacgcggg
    20461 attcgccgcg cgcagccggt tgcagcactt cttcgacgac atcaccaccg agacctcctc
    20521 ggagttgtcc cggctcgaag gcggcatgga ccagatcgcc cgccggctgg ccgaccgcct
    20581 gcgcgggccc gtgcaccacg ggcgcaaggt ggtcggcctg cacgtgcgcg acgacggtgt
    20641 ggtggtggag acgcgacgcg ggctggccac cgcggccagc cactgcgact acgtgctgtg
    20701 taccgtgccg ttctcggtgt tgcgcgggat ccggctcacc gggttcgacg acgccaagct
    20761 ggcggccgtg cacgacatgc agtactggcc ggcgacgaag atcgcggtgc actgccggga
    20821 ggcgttctgg gaacgggacg gcatcagcgg gggaggctcg tacaccggcg gtctggtggg
    20881 acagacctac tacccgccgg tggagagcga tccgttgctg ggggccgcgc tgctggccag
    20941 ttaccgcatc ggaccggagc cggacgccct ggtcaaggtg ccgcgggaga agcggacccg
    21001 tgtggtgctg gacgagctga gcgtgatcca cccgcagttg accgagcccg gcatggtgct
    21061 ggacgtcgtg acccaggcgt ggggcgagga cgctgccagc ctcggcgggg catcggtgcg
    21121 ctggagcaag gacatcgtga ccgcggagga ggaacgggcc ctcgcggcgc agccgcaggg
    21181 cacgctgttc ttcgccggcg agcactgctc gtcgtacccc gcgtggatcg agggcgcgat
    21241 cgagtccggg ctcgccgccg cccaggagat ccacgcgtgc gcgccggtcg cccagccggt
    21301 ccgctcccac ggctaccgcc ggattcccgg cggcgccgcc tgatgccgtg ctacgaaggg
    21361 gaagacagat gagctcgcta ctcaccaccg aggtgcttgt cgtcggcggt ggcccgaccg
    21421 gcatggcgat gggtctggag ctgcgctcgc gcggtgtcag cttcgtgctg gtggaggcgg
    21481 gcgacggcgc ggtgggccac cccagggtca gcggcatcgg cccgcgctcg atggagttct
    21541 tccggcgctg gggcatcgcc gaccggatcc ggcacgccgg ctggccgggc gaccacccac
    21601 tggactgcgt gtggaccact cgcatcggcg gtcacgagct gttccgcctc gaccggcaca
    21661 ccatggacac ccgcccggag ttccggcaca ccccggagcc cgacgcgatc tgcccgcagc
    21721 actggctcgg cccgctgctg cggtccgaac tcggtgagca ccccgacggg ccagtgcgga
    21781 tgcgcacgca gctggacgat ttcacgcagg acgccgacgg cgtgaccgcg accatcaccg
    21841 acctggagac gggcgcggtg acgacggtcc gggcccagtg cctgatcgcc tgcgacggca
    21901 ccgggtcgga gatccgcaag cagtgcggga tcggcgcgcc ggcccggcac gagacccagg
    21961 tgttccgcaa catcctgttc cgtgcgccgg aactgcggga gcgcctcggc gagcgcaacg
    22021 ccaacttctt ctacctgatg atctcctccg cgctgcggtt cccggtgcgt gccctcgacg
    22081 gcgcgggcct gtaccggctc accgtcggcc tccagggaga tccggagtcg cggcaggacg
    22141 cggagacctt ggtgcgtgcg gccatcgcgt tcgagacgcc ggtcgaggtg ctgtccgaca
    22201 acgaatggca tctcgtgcac cgcgtcgccg acaccttccg gcacggccgg gtcttcctgg
    22261 tcggcgacgc cgcccacacg ctgtccccgt ccggcggctt cggcatgaac accggtatct
    22321 gcggcgcggc cgacctcggc tggaagctgg cggccgagct ggggggctgg gcgggaccgg
    22381 gcctgctcgg cagctacacc accgagcgca agccggtcgc gctggaggga ctggaggaag
    22441 ccaaccgcaa cctcgaacgc gcgatgcggc gtcagatccc ggccgagctc aacgacgaca
    22501 ccccggaggg cgagttcgtc cgggccaaga tcagcgaggg actgcggcgc ggtggcgtgg
    22561 cccgtgagtt cgacgcgccc gagatccacc tcggcttcac ctacgcgggc tcgccgctga
    22621 tcgtgccgga tcccaccgcg gagaacaccg aggaccggcg gcccaacacc cgaccgggct
    22681 cccgcgcgcc gcacgcctgg gtcaagccgg gaatgtccac actggacctt ttcggcgacg
    22741 gcttcgtgtt gctgtgcttc gccgagtccg accggacggc cgcgttcacg gacgccttcg
    22801 gctcgcgcgg aatccccttc agcgtcgtcg tgctggacaa cgaggagatc gcgaaggtct
    22861 acgagcggcc gttcgtgctc gtccgcccgg acggacacgt ggcttggcgc ggccactcac
    22921 tgccggcacc cgctgccgcc ggggagatcg ccgaccaggt gcgcggcggt gcgcgatgac
    22981 cgcgacgatc ctgccgccgt tcagcctcca gggctggacc gatgccgacg ttcgtgatcc
    23041 gtacccgcgg tacgagcggt acctcgcgga gtcgccggtg catctggccg acggtgtcta
    23101 ctacgtcttc ggccacgacg ccgcgtcgac cgtgctgtcc agtcaggtct tcggccggcg
    23161 ggcggcgtcg ggcg
//
