LOCUS       NZ_CP073318            23030 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1105539
            Orig. end                         :: 1128569
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23030
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="9"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..23030
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23030
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13030](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13030)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     gene            498..1457
                     /locus_tag="JJ691_RS04830"
                     /old_locus_tag="JJ691_09650"
     CDS             498..1457
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF025878.4"
                     /locus_tag="JJ691_RS04830"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09650"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_211767592.1"
                     /transl_table=11
                     /translation="MSGSGPAGPAEVLSTSAVDETRAFEYWRDLICDTFVQLSATPTTS
                     RRFEGRLVHADLGDFEVTTVHAGGQRVRRTSRLIARTHEEYLLASIQTRGHGRIEQGGG
                     VAELGPGEMALYDSTRPYTLHFDDAFEQVVVQMPLGAMLAETGLRDARTVTAVKLGANS
                     TAGVVAQFFHSLSRLQQTDPLGAAALAPQGRGLMASALSLAAGRVPHSEVLTRQRVQAF
                     LRTHHGDPALSVDDVAQAFLISRRTLYRLFDGIPGGVGSLLRSIRVEHAKALLRNDPGR
                     PHDSVALACGFAGERQFYRVFRQETGLTPGQFRGTPGQ"
     gene            1540..2544
                     /locus_tag="JJ691_RS04835"
                     /old_locus_tag="JJ691_09660"
     CDS             1540..2544
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1294: Nitrilase/cyanide hydratase and apolipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020423109.1"
                     /locus_tag="JJ691_RS04835"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09660"
                     /product="carbon-nitrogen hydrolase family protein"
                     /protein_id="WP_211767593.1"
                     /transl_table=11
                     /translation="MTEQVRVAVVQVEPKWLDLAAGVDQVVGLIADAAAGGARLVAFPE
                     TFLPGYPWWIWLGSPAWGMQFVPRYAQNSMTRDGAEMTRIAAAAAEHGVHVVLGFSEND
                     GGSLYMAQAFIDDTGRVISVRRKLKPTHVERSVFGEGDGSDLQVHETSIGRIGGLNCWE
                     HFQPLTKYTMYSLGEQIHVGSWPSFSVYRGGAQALGPEVNTAASLVYAVEGQTFVLAPC
                     GVVGEAAQAVFCDDDVKKQLLLRGGGFARVYGPEGSELATPLAETEEGLLFADLDFSLI
                     AIAKSAADPVGHYSRPDVFRLHVNLGANPRIVHGSARQPEPEFEAVELVADGA"
     gene            2549..3565
                     /locus_tag="JJ691_RS04840"
                     /old_locus_tag="JJ691_09670"
     CDS             2549..3565
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025188.4"
                     /locus_tag="JJ691_RS04840"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09670"
                     /product="phenylacetaldoxime dehydratase family protein"
                     /protein_id="WP_211767594.1"
                     /transl_table=11
                     /translation="MESAIPAHLTVERTRPARKSTSFRPPYPSFSARFDPSVRQVVMAY
                     FGVQHRSATPPPVVSEALAHLASVGGGVNRERAQYVDEAGYHTTVEIRYWTDPAEFSSW
                     LADNDFWTAWPAVPDAGFFLEVVRPTVPRFETLFSNDRLEGVAVAADGLSGEIQEHGYW
                     GGARDRIPLAQNDLLAPIGDVSARTVGDLVTVVPNGNLCLIRSGQEWTETAGDERQMYL
                     TEVEPVLRAGMDFLRDDGLSVGCYANRYLRVLAADGGVTDKSFGLSWWRGLEDLETWSE
                     SHPTHVAIFRAALKYLSTMGPAARLRLYHEVTVVEPDQTRFEYVGCHPRTGLLRALG"
     misc_feature    3077..3079
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(3483..4136)
                     /locus_tag="JJ691_RS04845"
                     /old_locus_tag="JJ691_09680"
     CDS             complement(3483..4136)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015803814.1"
                     /locus_tag="JJ691_RS04845"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09680"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_211767595.1"
                     /transl_table=11
                     /translation="MTSRAESAAATRRALLDAAADLLDGGGPDAVTLREVGARAGVTRG
                     APYRHFPDKDSLLTTIAAEALDRLADQVRAIPKTSPADMLRHALDALMTIGRRQPHLYR
                     LMFTYPAGDPAAIDAAARAGDRAQGEFLAIISELVGPEHARRYGALLLTSAHGIADMEV
                     NGHLAPDKWDVTAEELVTMLVSMIDRQVNPVPATAPSSDGNRRTRTGSGPAPRR"
     misc_feature    complement(4144..4162)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.16"
                     /tool="antismash"
     misc_feature    complement(4153..4165)
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.27"
                     /tool="antismash"
     misc_feature    4189..4201
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 22.29"
                     /tool="antismash"
     gene            4189..5049
                     /locus_tag="JJ691_RS04850"
                     /old_locus_tag="JJ691_09690"
     CDS             4189..5049
                     /EC_number="1.1.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-174). E-value: 6.1e-13. Score:
                     41.0. Matches aSDomain:
                     nrpspksdomains_JJ691_RS04850_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015102958.1"
                     /locus_tag="JJ691_RS04850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09690"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_249227686.1"
                     /sec_met_domain="adh_short (E-value: 2.3e-33, bitscore:
                     114.9, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLSSETVVVTGASTGIGAATARELARRGLHVLAGVRRDRDADAL
                     RGDRIEPVILDITEPDHIAALTARIDSPLRALVNNAAVQTNAPVEALPLDEWRRLFEVN
                     LFGHIAVTQALLPALLRHAGRVINISSVGGRVAMPTYGPYAGTKFALEAVSDSLRRELA
                     PLGVPVVVIEPGAIRTDMASRVVAATNQAAAAMSPEHRDRYGNLIRAINAQSAAHTPNG
                     VSAADAAQVIATAVTARRPRTRYTIGRDAALITRLSRLLPDRLLDRMLTASLRPHYRQS
                     AAAGR"
     CDS_motif       4207..4275
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS04850_0001"
                     /evalue="9.60E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="JJ691_RS04850"
                     /protein_end="29"
                     /protein_start="6"
                     /score="18.3"
                     /tool="antismash"
                     /translation="TVVVTGASTGIGAATARELARRG"
     aSDomain        4207..4710
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS04850_PKS_KR.1"
                     /evalue="6.10E-13"
                     /label="JJ691_RS04850_PKS_KR.1"
                     /locus_tag="JJ691_RS04850"
                     /protein_end="174"
                     /protein_start="6"
                     /score="41.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVVVTGASTGIGAATARELARRGLHVLAGVRRDRDADALRGDRIE
                     PVILDITEPDHIAALTARIDSPLRALVNNAAVQTNAPVEALPLDEWRRLFEVNLFGHIA
                     VTQALLPALLRHAGRVINISSVGGRVAMPTYGPYAGTKFALEAVSDSLRRELAPLGVPV
                     VVIEP"
     CDS             5046..5255
                     /gene="allorf_01110585_01110794"
                     /locus_tag="allorf_01110585_01110794"
                     /protein_id="allorf_01110585_01110794"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MTSSGDSTGSECVAAGHNSAWTCGIRAWARACAAFGSCITLRPAT
                     RTSVGIVIDLRRSSRTPRFPWTPA"
     CDS_motif       5046..5093
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTSSGDSTGSECVAAG"
                     /locus_tag="allorf_01110585_01110794_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       5094..5255
                     /prepeptide="core"
                     /locus_tag="allorf_01110585_01110794_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.30"
                     /molecular_weight="5645.5"
                     /monoisotopic_mass="5642.0"
                     /core_sequence="HNSAWTCGIRAWARACAAFGSCITLRPATRTSVGIVIDLRRSS
                     RTPRFPWTPA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTSSGDSTGSECVAAG"
                     /leader_location="[5045:5093](+)"
                     /alternative_weights="5663.5"
                     /alternative_weights="5681.5"
                     /alternative_weights="5699.5"
                     /alternative_weights="5717.6"
                     /alternative_weights="5735.6"
                     /alternative_weights="5753.6"
                     /alternative_weights="5771.6"
                     /alternative_weights="5789.6"
     gene            complement(5252..5650)
                     /locus_tag="JJ691_RS04855"
                     /old_locus_tag="JJ691_09700"
     CDS             complement(5252..5650)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009946206.1"
                     /locus_tag="JJ691_RS04855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09700"
                     /product="VOC family protein"
                     /protein_id="WP_211767597.1"
                     /transl_table=11
                     /translation="MRFASVRVITDDVARLVTFYEQATGLQARWATEQFAEFVTPSCTL
                     AIGSVQTMALFSPGAAVPEANRTAILEFLVDDVDREHDRLTGLAPEIVQPPTTMPWGNR
                     SLLFRDPDGNLVNFFTPVTEQARARLDH"
     misc_feature    5696..5714
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.1"
                     /tool="antismash"
     gene            5738..6700
                     /locus_tag="JJ691_RS04860"
                     /old_locus_tag="JJ691_09710"
     CDS             5738..6700
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020499511.1"
                     /locus_tag="JJ691_RS04860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09710"
                     /product="YafY family protein"
                     /protein_id="WP_211767598.1"
                     /transl_table=11
                     /translation="MTRPIARVLTLLEILQGGGTRTVAELAGRLDVDERTVRRYVEHLL
                     DLEIPVRSVRGRYGGYRLAPGYRMPPLMLTGDEALAVLLGLVAGRRAGLVTTSVAAAES
                     AVAKVRRVLPEDLGRRLDALLEIADFTAPARSTLTAEAEVLLTVAEAARDRRPVELAYL
                     AGHGGASERVVHPYGVVAHSGRWYVTGLDSISGQVRTFRIDRITAVRTLTGTFDVPTGF
                     APGPHVLTALAEAPHQHDVSVRIEATPDQIRATFPPSVAVLTEITGTSWVRARIRAERL
                     DWIAPLLAALDRPFVIERPDDLRDLVRALATRLAAHAEA"
     gene            complement(6704..9619)
                     /locus_tag="JJ691_RS04865"
                     /old_locus_tag="JJ691_09720"
     CDS             complement(6704..9619)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1149: LuxR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015804021.1"
                     /locus_tag="JJ691_RS04865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09720"
                     /product="LuxR family transcriptional regulator"
                     /protein_id="WP_211767599.1"
                     /transl_table=11
                     /translation="MQTRAPLLVGRDAELVELTRALSGARAGRGGSANLVGEAGIGKSR
                     LAAMIAGRAFDTGMRVLRGRGSAIGPMVPFRPLAEALLSLFRGGESFADSELGPYRPAL
                     GRLIPEWGGDAPASPASLVVLAEAVLRLLAVAGRDRGCLLVLEDLHDADAETLAVVEYL
                     TDNLEFQPIMLLATIRSEPGAALDLARAGEQRRTSRLLELRRLDRTQVRAMAASCLEIP
                     APDVVDDVVQRLWADSAGNPFVVEELLHGMVNSGLLVPSEEGWQVVGALRTEVPAAVAR
                     SIANRTDRLGPQGRMVLSVAAVLGHRFPLSVVREVADIDDRGLLSHLHAGVAAQLVTPD
                     EPAPDWYAFRHPLTAEALLSQLTPLDRAELSSKAADAVLELHPELPGHWCQLVASLRLD
                     AGEDAAAGRLFAEAGRRALRDGAAGSAITLLDKANRLLTRRLDAGIRADILESLLPALA
                     EAGHFDRAFQLAGKLADLDGDGLDARRRAALHTRLAKVAYLAGRSADGAEQVAAARALL
                     GPLPSDEDTARVDVVAAYVEMDMPRPDRLIRAEELALRAVAAAERSEQPVVACEAWELL
                     GIITREHDISRAVECLERARQLGEQHQLPLQRAYAVMRLAGIDWLSTSDTLSLERAREE
                     ALRIGAITMAYNADAILALHTVLGGDFSLAAERIDACAESATRLQLGSMVRYTLMAKAT
                     LAGHQGRRREMDDALAEFRQWGGEKSQEMPLSVGLARVFCALLEENRPLALRELAEALA
                     FETATPTTFHLAGRHGLDLLLGVLDRRYDWSHYREVADTPAGRMRWNLQFTELAAAVLH
                     GRDGDSAQACDAMASAQQAGAAFPLARHLGLRLVAESAHADRWGDPVAWLRRAEEYFHH
                     NTITGAASACRALLRQVGVSVQQRRVGAEQVPTALRSLGVTVREYDVFRLLVDRLGNKA
                     IATRLHISPRTVEKHVASLIAKTQQPDREALSTYASAILAP"
     gene            complement(9760..9966)
                     /locus_tag="JJ691_RS04870"
                     /old_locus_tag="JJ691_09730"
     CDS             complement(9760..9966)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS04870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_09730"
                     /product="hypothetical protein"
                     /protein_id="WP_211767600.1"
                     /transl_table=11
                     /translation="MTEMTAPENDVESATASGENPAGQIVVNARTRAGARARALAGLTL
                     GMSAFMAITAVPSTTVSAPGQLF"
     gene            complement(10001..13030)
                     /locus_tag="JJ691_RS04875"
                     /old_locus_tag="JJ691_09740"
     CDS             complement(10001..13030)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015103770.1"
                     /locus_tag="JJ691_RS04875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09740"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_249227687.1"
                     /sec_met_domain="DUF4135 (E-value: 4.7e-108, bitscore:
                     360.9, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 3.6e-34, bitscore:
                     117.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKSATFWWAGGLTLHERLPRTSPQPRTAQLLGGTATALARLERW
                     RRAHEELAPDWFERRLAAVGLDEKLLTGLLAEAPDALARRVARPGWADFVDSALTTPSG
                     RRKAFGDDWIGVLAAGLRPLVSVAEEAVASAACPEVTAGFAHRLGRRLARLAARTLVLE
                     LNLARTRGGLAGRTPQERFAEFAVRPDLDALFAEYPVLARLLAQACQQAVLAHLELLER
                     LASDRDTIIETLLDGRDPGMLAAIESTEGDAHQHGRSVALLTFADGRTVVYKPRPLDLH
                     AHFNDMLDWLNGRVPSLGLRKVTLLGREGYGWQEFVAAVPCDEVTGLSRFYRRQGALLA
                     LLYAVDGSDMHYENLIAHGDQPVLIDVETLCHPTMRVDTAAGPDPAAQELVRSVFRTAL
                     LPQVMLGENGSLDISGLGGDQGVFPTDGVGWDGAGTDSMRLVRRPVAMRGGRNRPRLGR
                     REAEPRDYQAALLTGFQAGYDAIVEHRGELVALLRACADDELRFVARPTQLYATLLDES
                     THPDVLRDALDRDSVFDLLWTDSLDDPMRRRLVPHEIADLWAGDVPMFTTRVGTRDVWS
                     ANGVRLSGLLAESGLAAVEAKLADMGEVDRHNQEWLIRASFATRPQPVTHRGAAVLPGA
                     VASVVPDPQRLVAAACGIADELVGRAVPGLDRTNWLGLELVDDRQWTVLPMGAGLANGY
                     PGLALFLAQLAELTGAPRYGDLARRAIRPIPRLLDALGDDLALAMDVGSGGFHGLGGIC
                     YALARLHRLLDDDAEVLGWLARAVRLATALETEAGDEPADIAGGLAGGLAAMLAVHAET
                     GLASAGTLAIRYADRLATGRHATTDTVGFARGPAGVGWALLRLASAIGSDRHEAVGLDY
                     LAAEGDPAAPGDFGWCAGLPGSMLARIGRTDERLAGWVDALAGRSPLRDLSLCHGELGA
                     MEALIVLGRAGDERAAAAVVRRAGLVLGSLDQYGARCGTPGEVPTPGLLSGLAGIGYGL
                     LRLGLPGRVPSVLLLEPSGH"
     gene            13194..13541
                     /locus_tag="JJ691_RS04880"
                     /old_locus_tag="JJ691_09750"
     CDS             13194..13541
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS04880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_09750"
                     /product="hypothetical protein"
                     /protein_id="WP_211767602.1"
                     /transl_table=11
                     /translation="MALAVAVLAAGGAPAAFGGARGCNKRTCVEVDGSGLHVNYIAAST
                     TWNGDFSGHFHIWGGGIDQNSGTGFWGYHQVYKVGVGRDLPNRAVVCAEGWEHAGGRLN
                     SMGRACEEIKF"
     gene            complement(13807..14952)
                     /locus_tag="JJ691_RS04885"
                     /old_locus_tag="JJ691_09760"
     CDS             complement(13807..14952)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014741.4"
                     /locus_tag="JJ691_RS04885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09760"
                     /product="DUF222 domain-containing protein"
                     /protein_id="WP_211767603.1"
                     /transl_table=11
                     /translation="MKEIARELESMEPSGVMVDLLLGVDVESLTDDQKLTLLIVTRKVM
                     AALHYVELSLVRGIEDTAEIAMAVHDPEQSVVRQKEYSDVLDRLPQCAELLRRGEIDPR
                     RLKTIDDRVVHLTDPELVAQVDETLAEVAPGLTRTQLARRATKAVAEANPLGYDQRRLK
                     AREDRRVEFTPLPDGMAQLSIILPAIDARQAYDLLTQDARALVKDDRTTDQKRADAFLD
                     RFLGYGVDRTVQVHVTIPVETLMGLTEDPGLLDGYGPIAADSARELAMHGPWRGILLDN
                     RRHADAMTTHKYRADTRTREFIKVRDGGTCTAPGCTTPIQELDHTTPWPVGKTTATQLK
                     GYCAHHHHLKHRDYTATLDEDGTLHWHTPQGRHYTTQPHQY"
     misc_feature    14955..14971
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     CDS             14999..15199
                     /gene="allorf_01120538_01120738"
                     /locus_tag="allorf_01120538_01120738"
                     /protein_id="allorf_01120538_01120738"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MNSAGLTGSPQGPSPLTSEGGFCVEGGDGISCRRSRRAQPARFFA
                     SMPSPRGSTQNPPGATQKPTR"
     CDS_motif       14999..15061
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNSAGLTGSPQGPSPLTSEGG"
                     /locus_tag="allorf_01120538_01120738_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       15062..15199
                     /prepeptide="core"
                     /locus_tag="allorf_01120538_01120738_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.20"
                     /molecular_weight="4720.3"
                     /monoisotopic_mass="4717.4"
                     /core_sequence="FCVEGGDGISCRRSRRAQPARFFASMPSPRGSTQNPPGATQKP
                     TR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNSAGLTGSPQGPSPLTSEGG"
                     /leader_location="[14998:15061](+)"
                     /alternative_weights="4738.3"
                     /alternative_weights="4756.3"
                     /alternative_weights="4774.3"
                     /alternative_weights="4792.3"
                     /alternative_weights="4810.4"
                     /alternative_weights="4828.4"
     CDS             complement(15045..15179)
                     /gene="allorf_01120584_01120718"
                     /locus_tag="allorf_01120584_01120718"
                     /protein_id="allorf_01120584_01120718"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MLRVDFAWSLWAMASRQRSGQAAPASIADSLCHRPPPRKIHPPR"
     CDS_motif       complement(15111..15179)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MLRVDFAWSLWAMASRQRSGQAA"
                     /locus_tag="allorf_01120584_01120718_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(15045..15110)
                     /prepeptide="core"
                     /locus_tag="allorf_01120584_01120718_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="2309.7"
                     /monoisotopic_mass="2308.3"
                     /core_sequence="PASIADSLCHRPPPRKIHPPR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MLRVDFAWSLWAMASRQRSGQAA"
                     /leader_location="[15110:15179](-)"
                     /alternative_weights="2327.7"
     gene            complement(15203..16096)
                     /locus_tag="JJ691_RS04890"
                     /old_locus_tag="JJ691_09770"
     CDS             complement(15203..16096)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS04890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_09770"
                     /product="hypothetical protein"
                     /protein_id="WP_211767604.1"
                     /transl_table=11
                     /translation="MLRTSAVVLLAALSLLVPTVPAHATTATATNTKSAAALDSYWTPQ
                     RLAAAKPMPAPTAARSTTQEQVGEPKFVHSTAPISSGPSRFQPMSSVWSTIGRLVFSVP
                     GKGDYLCTANVVTSNNRDVIATARHCVMDISTGQTYNNFRFAPSYNQGNAPYGWWNWRS
                     MGWRVDDTSPGGDNAFIVLSTGGNNNSHVQDAIGSSGIGFNQPSNSYAHGIGIPADKDY
                     AVWCEGQPYDGPQGGVQIPNCNGLSGGASGGAFIVNYQGDGTAMQTGSFFGSWGDSYFA
                     YYRDAAWQVYNGAQNA"
     gene            16234..16719
                     /locus_tag="JJ691_RS04895"
                     /old_locus_tag="JJ691_09780"
     CDS             16234..16719
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS04895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_09780"
                     /product="hypothetical protein"
                     /protein_id="WP_211767605.1"
                     /transl_table=11
                     /translation="MFRRASELGDRLLELSRFKYPPDTIALEHGARLAGYLDDDESLLE
                     VVHARRSFGATVACGLVLTGERFIFMPETRHLGEVRKILPGSGGAFGLPLSAVTAVRTS
                     GQPEETDWLEDLFTHQSSHAGLVIAARGLGELHFESVVPVDGPGRVVDRVREMGIRG"
     CDS             16737..16901
                     /gene="allorf_01122276_01122440"
                     /locus_tag="allorf_01122276_01122440"
                     /protein_id="allorf_01122276_01122440"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MGTTTVPGKSAGQICEVPGGGCVCGCSYVSIRRGLWNLPACAGNS
                     RRSLTVSQG"
     CDS_motif       16737..16796
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MGTTTVPGKSAGQICEVPGG"
                     /locus_tag="allorf_01122276_01122440_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       16797..16901
                     /prepeptide="core"
                     /locus_tag="allorf_01122276_01122440_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.20"
                     /molecular_weight="3464.0"
                     /monoisotopic_mass="3461.7"
                     /core_sequence="GCVCGCSYVSIRRGLWNLPACAGNSRRSLTVSQG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MGTTTVPGKSAGQICEVPGG"
                     /leader_location="[16736:16796](+)"
                     /alternative_weights="3482.0"
                     /alternative_weights="3500.0"
     CDS             complement(17033..17239)
                     /gene="allorf_01122572_01122778"
                     /locus_tag="allorf_01122572_01122778"
                     /protein_id="allorf_01122572_01122778"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MCQTRCRRGPTSSRTDARWSARQRTSAATEDVADEEFRNSPFVRA
                     CGQTWPTGGMRRTAIGCSRARLA"
     CDS_motif       complement(17153..17239)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MCQTRCRRGPTSSRTDARWSARQRTSAAT"
                     /locus_tag="allorf_01122572_01122778_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(17033..17152)
                     /prepeptide="core"
                     /locus_tag="allorf_01122572_01122778_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.40"
                     /molecular_weight="4222.7"
                     /monoisotopic_mass="4220.1"
                     /core_sequence="EDVADEEFRNSPFVRACGQTWPTGGMRRTAIGCSRARLA"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MCQTRCRRGPTSSRTDARWSARQRTSAAT"
                     /leader_location="[17152:17239](-)"
                     /alternative_weights="4240.7"
                     /alternative_weights="4258.7"
                     /alternative_weights="4276.7"
     misc_feature    17251..17269
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.7"
                     /tool="antismash"
     gene            17322..18452
                     /locus_tag="JJ691_RS04900"
                     /old_locus_tag="JJ691_09790"
     CDS             17322..18452
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0006817 - phosphate ion transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018331927.1"
                     /locus_tag="JJ691_RS04900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09790"
                     /product="inorganic phosphate transporter"
                     /protein_id="WP_211767606.1"
                     /transl_table=11
                     /translation="MDLSLLVIVVIVTALAFDFTNGFHDTANAMATSIATGALSPRVAV
                     GVSAVFNLVGAFLSVQVAKTISSGIVDEAKINSAIIFGGLVGAIVWNLLTWLLGLPSSS
                     SHALFGGLIGATWIAAGSDAVHFETVLEKVIVPALASPIIAGVVATLATWVAYKITEKS
                     DKTERAKGFKAGQILSASLVSLAHGTNDAQKTMGVITLTLIAAGTLPAGSNPPLLVILG
                     SGLAISLGTFLGGWRIIRTLGKGLTEIETPQGFAAEASATATILASTQVGFALSTTHVA
                     TGAIIGSGVGKRLSEVRWGVAGRMALAWLFTLPAAAIVGAIAGRTASLGNVGTVIVAVA
                     AVVVAVGAYLLSRRQPVSAGNVNEMPSTSAPATASA"
     misc_feature    17338..17352
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.38"
                     /tool="antismash"
     gene            18467..18670
                     /locus_tag="JJ691_RS04905"
                     /old_locus_tag="JJ691_09800"
     CDS             18467..18670
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS04905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_09800"
                     /product="hypothetical protein"
                     /protein_id="WP_211767607.1"
                     /transl_table=11
                     /translation="MTINWGGLGEVFVVAIVASVLFVGLFSVGIGAWTRRGEAVLNNVL
                     AIGCFVLCAVIIGYGIFAIAHK"
     CDS_motif       18467..18523
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MTINWGGLGEVFVVAIVAS"
                     /locus_tag="JJ691_RS04905_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       18524..18670
                     /prepeptide="core"
                     /locus_tag="JJ691_RS04905_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-7.00"
                     /molecular_weight="5014.0"
                     /monoisotopic_mass="5010.8"
                     /core_sequence="VLFVGLFSVGIGAWTRRGEAVLNNVLAIGCFVLCAVIIGYGIF
                     AIAHK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MTINWGGLGEVFVVAIVAS"
                     /leader_location="[18466:18523](+)"
     gene            complement(18725..20224)
                     /locus_tag="JJ691_RS04910"
                     /old_locus_tag="JJ691_09810"
     CDS             complement(18725..20224)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226093.1"
                     /locus_tag="JJ691_RS04910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09810"
                     /product="glycoside hydrolase family 76 protein"
                     /protein_id="WP_249227688.1"
                     /transl_table=11
                     /translation="MLRAAALCALVLTVVLAPVAAASTGAPPTPAPTTAAPPPSTGNTV
                     KPMATICDKYCDGRDPALAQQSRQGTVTAAGSRQLSLYLDDNDDMGYAAITNSSPGDEL
                     WMDRSFDAGRSWASGSKIGDTRTPSGYPGWRTLMFNVDDWNNNGIGLLRACALPAGSST
                     ITCTDWRRTTWNSYDRRTAAATALMEDYNNTTGLFDTTGWWNSANALTAVIDNIRVAGM
                     GSYAYTIANTYNKNLSAQGGNFTNPYNDDTLWWGLAWVEAYDLTGDSRYLTTARFDADH
                     VFAYWDSTCGGGVWWSSAKTYKNAIPNSLYIELNAALHNRIPGDTTYLQRAQAGWTWFR
                     NSGMINGQNLVNDGLTSTCANNNQPTWSYNQGVPLAALTELYRATGNGSYLTQARTLAD
                     ASTTSVSLNPNGILHDPGDQPGGGGADGPTFKGVYARGLSALNAALSDHPYSTYLNRQA
                     DSAYASDRNGFDQYGLVWSGPFDQSDAARQQSALDLMNAAG"
     misc_feature    complement(20269..20283)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.07"
                     /tool="antismash"
     misc_feature    20291..20308
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.77"
                     /tool="antismash"
     gene            20337..20831
                     /locus_tag="JJ691_RS04915"
                     /old_locus_tag="JJ691_09820"
     CDS             20337..20831
                     /EC_number="3.1.3.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1101: phosphoglycerate mutase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012521.4"
                     /locus_tag="JJ691_RS04915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09820"
                     /product="histidine phosphatase family protein"
                     /protein_id="WP_211767608.1"
                     /transl_table=11
                     /translation="MRLLLVRHAESLAMTRNLTVSNDNCPGLTSVGFDQARELGRRLDV
                     RPDVLVRSPVTRARQTADELIAALRPPRTEIDRDLAEVDIDEPWNGFLSRVDNVLTTWP
                     ERYAGQTVMAVTHAGFMVWVFMTLFGVPRPGTGARVDFDFASVTEWQFSGGWRLVSLNL
                     T"
     gene            20831..21322
                     /locus_tag="JJ691_RS04920"
                     /old_locus_tag="JJ691_09830"
     CDS             20831..21322
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1111: GCN5-related N-acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009942431.1"
                     /locus_tag="JJ691_RS04920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09830"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_211767609.1"
                     /transl_table=11
                     /translation="METERLLLRPAEPSDVDDLRALDADPEVMRFLGTDGASSVELIGR
                     TDYWVGIERASGDFVGWFGLADELGYRIRRDKWGRGYATEGAKALLDKAFAEGRERVTA
                     QTMAVNTGSRRVLEKLGLRHVRTFHVDWENPLPGSEHGEVEYEISVWPAGTGTAPPRAR
                     "
     gene            complement(21273..22439)
                     /locus_tag="JJ691_RS04925"
                     /old_locus_tag="JJ691_09840"
     CDS             complement(21273..22439)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1066: alpha/beta hydrolase domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF019474.4"
                     /locus_tag="JJ691_RS04925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_09840"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_211767610.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.1e-12, bitscore:
                     46.2, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRTGIALAVAAGVGGVALNVFARRTPWRRAPWHLAGMAAGVVAT
                     ELSVPVAAAQLGATGVAAALGAGRSKIGAAALAVSAGAAVGLAALQRPAAETGRHLQGA
                     LDEVLGHGTVTLNAPTPAWPGKFRRGEFIAAEGVGYGNDQVLDVWRKPGVTGAPVLIQV
                     HGGAWTSGDRRQQNLPLLAHLADRGWVCVAIDYRLGPKNRWPAQIVDVKRAIAWVRANI
                     ERYGGDPSFIAITGGSAGGHLAALAAVTGNDPAFQPGFEDADTSIQAGVPLYGVYDLDA
                     RNEDGSSGLRDHVRRVMIDEERDVAAASPIHRITPDSPPLLVVHGNRDEVVSVNQAREF
                     ATRARELGAPIGYAELPYAHHAFDSLPSARTAATAHAVELFLSQLAKH"
     misc_feature    complement(22483..22498)
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 17.4"
                     /tool="antismash"
     gene            22530..22982
                     /locus_tag="JJ691_RS04930"
                     /old_locus_tag="JJ691_09850"
     CDS             22530..22982
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS04930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_09850"
                     /product="molybdopterin-binding protein"
                     /protein_id="WP_211767611.1"
                     /transl_table=11
                     /translation="MTPLRPDELVITGEVATPGTVWCTSALHARACRPITVDYVTLRRT
                     ERHEVRGVTLYEALAAAGLALDPARKMDHLSLAVLAEGADGYGVLVSYAELHPEFGDCG
                     ALLATWHNGQLLARPTLVMPADRRASRFVRQVHRLHVVHPVAAQTF"
ORIGIN
        1 gcaactacga caacctggcc gtgtaccggc cgtccaacag caccttctac atccgcaagt
       61 ccgacggcag cctgctgacc caggtggtgt tcggcgcgtc cggtgacatc ccggtcgtgg
      121 ggcacttcga ggacagcgcg tacgacaacc tcgcggtgta ccggccgtcc aacagcacct
      181 tctacatccg caagtccgac ggcagcctgc tgacccaggt cgtgttcggc gcgcagggcg
      241 acatcccgat ggtcggacac ttcgagaaca gcggctacga caacctgggc gtctaccggc
      301 cgtccaactc cagctactac atccgcaagt cggacggcag cctgctgacg caggtgttct
      361 tcggcgccag cggcgacctc ccggtggtcg gccacttcga gtgaccgtga ccatgggcgg
      421 cccgttcctc cgggagcggg ccgcctttcc gcgcgcagcc gttgcgcggc tgacccgcgt
      481 cggcgcacta tgacgcgatg agcggctcgg ggcccgccgg tccggccgaa gtcctgtcca
      541 cctcggccgt tgatgagacg cgcgcgttcg agtactggcg ggacctgatc tgcgacacgt
      601 tcgtgcagct ctcggcgacg ccgacgacct cgcggcggtt cgagggccgg ctggtgcacg
      661 ccgatctcgg ggacttcgag gtgacgacgg tgcacgccgg cggccagcgg gtccgccgca
      721 cctcccggct gatcgcccgc acgcacgagg agtacctgct cgccagcatc cagacccgcg
      781 gccacggccg gattgagcag ggcggcgggg tggccgagct gggcccgggc gagatggccc
      841 tctacgacag cacccgtccg tacaccctgc atttcgacga cgcgttcgag caggtcgtgg
      901 tgcagatgcc gctgggggcg atgctggccg agacgggcct gcgcgacgcg cggaccgtga
      961 cggcggtgaa gctcggcgcg aacagcaccg ccggtgtggt ggcccagttc ttccacagcc
     1021 tttcccgtct ccagcagacg gatccgctcg gcgcggccgc gctggcaccc cagggccggg
     1081 ggctgatggc gtccgcgctg agcctggccg ccggccgcgt cccgcacagc gaagtcctta
     1141 cgcggcaacg cgtccaggcc ttcctacgga cccatcacgg tgacccggcg ttgagcgtcg
     1201 acgacgtcgc ccaggcgttc ctgatctcca ggcggacgct gtaccggctg ttcgacggca
     1261 tcccgggcgg agtgggctcg ctgctgcgga gtatccgggt ggagcacgcg aaagccttgc
     1321 tacgcaacga tcctggtcgt ccgcacgact cggtggcgct ggcctgtggg ttcgccgggg
     1381 agcgccagtt ctaccgggtg ttccggcagg agaccggcct gacgcccggc cagttccgtg
     1441 gcacgcctgg tcagtgaggc ggcacgcgct gtcggtccgg gccgtgtggt gagcgtccga
     1501 tagtggggcg gtagtcagga ctcactgcgg aggcgtgcga tgacagagca ggttcgcgtt
     1561 gccgttgtcc aggtcgagcc caagtggctg gacctggcgg ccggggtcga ccaggtggtc
     1621 ggcctgatcg ccgacgccgc cgccggcggg gcccggctgg tggcgttccc ggagaccttc
     1681 ctgccgggct acccgtggtg gatctggctc ggctcgccgg cctggggcat gcagttcgtg
     1741 cctcgctacg cccagaactc gatgacccgc gacggcgcgg agatgacccg gatcgccgcc
     1801 gcggcggccg agcacggcgt gcacgtggtc ctcggcttca gcgagaacga cggcggcagc
     1861 ctgtacatgg cgcaggcgtt catcgacgac accggccgcg tgatctccgt gcgccgcaag
     1921 ctgaagccga cccacgtcga gcgcagtgtg ttcggcgagg gcgacggcag cgacctccag
     1981 gtgcacgaga ccagcatcgg ccgcatcggc gggctgaact gctgggagca cttccagccg
     2041 ttgaccaagt acacgatgta cagcctgggc gagcagatcc acgtcggctc gtggcccagc
     2101 ttctcggtct accgcggtgg cgctcaggcc ctgggcccgg aggtcaacac cgccgccagc
     2161 ctcgtgtacg ccgtggaggg ccagaccttt gtgctcgcgc cgtgcggtgt ggtcggcgag
     2221 gcggcccagg cggtgttctg cgacgacgac gtgaagaagc agcttctgtt gcggggcggg
     2281 ggtttcgccc gggtctacgg tcccgagggc agtgagctgg cgacgccgct ggctgagacc
     2341 gaggagggac tgctgttcgc ggacctggac ttctcgctta tcgccatcgc caagtccgcc
     2401 gccgacccag tcggccacta ctcgcggccc gacgttttcc gcctgcacgt caatctcggc
     2461 gccaacccgc gcatcgtgca cggttcggcg cgccagcccg agcccgagtt cgaggccgtc
     2521 gagctcgtcg ccgacggggc gtgacgccgt ggagtcggcg attcccgcgc acctgacggt
     2581 cgagcggacc agaccggccc gcaagtcgac ctcgttccgg ccgccctatc cgtccttctc
     2641 ggcccggttc gacccgtcgg tgcggcaggt ggtcatggcc tacttcggcg tgcagcaccg
     2701 atcggcgacc ccgccgccgg tggtttcgga agctttggca cacctggctt ctgttggtgg
     2761 tggcgtgaac cgtgagcgtg cgcagtacgt cgatgaggcc ggataccaca ccacggtgga
     2821 gattcggtac tggaccgacc cggccgagtt ttcgtcctgg ttggcggaca acgacttctg
     2881 gaccgcctgg ccggccgttc ccgatgccgg cttcttcctg gaggttgtgc ggccgaccgt
     2941 gccccggttc gagaccctgt tctccaacga ccgtctggag ggcgtcgccg tcgccgccga
     3001 cgggttgagc ggcgagatcc aggagcacgg ctactggggc ggggcccgcg accggattcc
     3061 cctggcccag aacgatttac tcgccccgat cggtgacgtg tcggcgcgga ctgtcggcga
     3121 tctcgtgacc gtggtgccca acggcaacct gtgcctgatt cgctccggcc aggagtggac
     3181 cgagaccgcc ggtgacgagc gccagatgta cctcacggaa gtcgagccgg tgctccgagc
     3241 cggcatggat tttctccgtg acgacgggct ttccgtcggc tgctatgcga accgctacct
     3301 ccgggtgctg gccgccgacg gcggcgtcac cgacaagagc ttcgggctca gctggtggcg
     3361 cggcctggag gatcttgaga cgtggtccga gtcccatccc acgcacgtcg cgattttccg
     3421 tgctgcgttg aagtatctgt ccaccatggg gccggcggcg cggctgcggt tgtaccacga
     3481 ggtcaccgtc gtggagccgg accagacccg gttcgagtac gtcggttgcc atccgaggac
     3541 ggggctgttg cgggcactgg gttgacctgt cggtcgatca tggacaccag catcgtgacg
     3601 agttcttcgg cggtgacgtc ccacttgtcc ggggccaggt gtccgttgac ctccatgtcg
     3661 gcgatcccgt gcgcgctggt caacagcagt gcgccgtaac gacgagcgtg ctcgggaccg
     3721 accagttcgc tgatgatggc caggaactcg ccctgggcgc ggtcgccggc ccgggcggcg
     3781 gcgtcgatcg cggccgggtc gccggccggg taggtgaaca tcagccggta caggtgcggc
     3841 tggcggcggc cgatcgtcat cagggcgtcc agggcgtggc gcagcatgtc ggccggagat
     3901 gtcttgggaa tggcccggac ctggtcggcg agccggtcca gggcctcggc ggcgatggtg
     3961 gtcagcaggc tgtccttgtc ggggaagtgc cggtagggcg cacctcgggt gacgcccgcc
     4021 cgcgccccga cctcgcgcag cgtcaccgcg tccgggccgc cgccgtccag caggtcggcg
     4081 gccgcgtcca gcagggcccg tcgcgtggcg gcggctgatt cggcgcggct ggtcatgccg
     4141 gcgagcttac agttgacagt gtcatctgag ctgcctaccg tcgttcaggt gacattgtca
     4201 tccgaaaccg tcgtcgtgac cggggcctcg accggcatcg gcgcggcgac cgcccgcgag
     4261 ctggcccgcc gcggcctcca cgtcctggcc ggcgtccgcc gcgaccggga cgccgacgcc
     4321 cttcgcggcg accgcatcga gcccgtcatc ctcgacatca ccgagcccga ccacattgcc
     4381 gcgctgaccg cccgcatcga ctcgccgctc cgggcgctgg tcaacaacgc cgccgtgcag
     4441 accaacgccc ccgtcgaggc gctgccgctg gacgagtggc ggcggctgtt cgaggtcaac
     4501 ctgttcgggc acatcgccgt cacccaggcc ctgctgccgg cgctgctgcg ccacgccggc
     4561 cgcgtgatca acatcagctc cgtcggcggg cgggtcgcca tgcccaccta cggtccctac
     4621 gccggtacca agttcgccct cgaagccgtc agcgactccc tgcgccggga actcgccccg
     4681 ctgggcgtgc cggtcgttgt catcgagcca ggcgccatcc gcaccgacat ggcgtcccgc
     4741 gttgtcgccg ccaccaacca ggccgccgcc gccatgtccc ccgaacaccg tgaccgctac
     4801 ggcaacctga tccgggccat caacgcccag tccgccgccc acacccccaa cggcgtctcc
     4861 gccgccgacg ccgcccaggt catcgccacc gccgtcactg cccgtcggcc tcgcacccgc
     4921 tacaccatcg gccgcgacgc cgccctgatc acccgtctct cacggctgct gcccgaccgg
     4981 ctactggacc gtatgctcac ggccagcctt cggccccact accgacaaag cgcagcagct
     5041 ggtcgttgac ctcgtccggc gactccaccg gcagcgaatg cgttgccgcc ggccacaatt
     5101 cggcttggac atgcgggatc agggcttggg cgcgggcatg tgcggccttc gggtcgtgca
     5161 tcacgcttcg gccggccacc aggaccagcg tcgggatcgt gatcgacctc aggcggtcct
     5221 caagaacccc ccgattccca tggacgccag cctagtggtc cagcctcgcg cgggcctgct
     5281 ccgtgaccgg ggtgaagaag ttgaccaggt tgccgtcggg gtcgcggaac agcaaggagc
     5341 ggttgcccca cggcatggtg gtcggcggct gcacgatctc gggggcgagg ccggtcaggc
     5401 ggtcgtgctc gcggtcgacg tcgtcgacga ggaactcgag gatcgcggtc cggttggcct
     5461 cgggtacggc tgcgcccggg ctgaacaggg ccattgtctg gacgctgccg atggccaggg
     5521 tgcaggaggg ggtgacgaac tcggcgaact gctcggtggc ccagcgggcc tggagaccag
     5581 tggcctgctc gtagaacgtg acgaggcggg cgacgtcgtc ggtgatgacg cggactgagg
     5641 cgaaacgcat ggcggatcct tccggttctg gaggggacgc cggccacgct aggggcaata
     5701 gtggacagga tccgcccggt attggcacga tctttccgtg acccgtccga tcgcccgtgt
     5761 gctgaccctg ctggagatcc tccagggcgg tggcacccgg acggtcgcgg agctcgccgg
     5821 gcggctggac gtggacgagc gcacggtgcg ccgctacgtc gaacacctcc ttgacctcga
     5881 gatcccggtc cgctcggtgc gcggccggta cggcgggtac cgcctggctc cgggctaccg
     5941 gatgcccccg ctgatgctca ccggcgacga ggccctggcc gtcctgctcg gtctggtcgc
     6001 cggccggcgc gcggggctgg tcaccacgtc ggtggcggcc gccgagagcg cggtggcgaa
     6061 ggtccggcgg gtgctgcccg aggacctggg ccgccgactc gacgcgttgc tggagatcgc
     6121 cgacttcact gcgccggcac ggtcgacgct cacggcggag gccgaagtgc tgctcaccgt
     6181 ggccgaagcg gcaagggacc ggcgtcccgt cgagctcgcc tacctcgccg gccacggcgg
     6241 cgcgagtgaa cgcgttgtcc atccgtacgg ggtcgtggcc cattccggac gctggtacgt
     6301 gaccggcctc gactccatca gcggacaggt gcgcacgttc cgcatcgacc ggatcaccgc
     6361 cgtccggacg ctcaccggaa ccttcgacgt gccaacgggt ttcgcgcccg gcccgcacgt
     6421 cctcaccgcg ctggccgagg cgccgcacca gcacgacgtg tccgtgcgca ttgaagcgac
     6481 acccgatcag atccgtgcca cgttcccgcc ttccgtggcg gttctgaccg agatcaccgg
     6541 cacttcctgg gtacgggccc ggatccgggc cgaacggctc gactggatag cacccctgct
     6601 cgccgccctc gaccggccgt ttgtcatcga acgacccgac gacctccgcg atctggtgcg
     6661 ggcgctggcc actcgactgg ccgcccacgc cgaggcctga ggcctacggg gcgaggatgg
     6721 cgctggcgta ggtgctgagg gcttcgcggt cgggctgctg ggtcttggcg atgaggctgg
     6781 cgacgtgttt ttccaccgtg cgcggggaaa tgtgcaggcg ggtggcgatg gctttgttgc
     6841 cgaggcggtc gacgagcaga cggaagacgt cgtactcccg cacggtgacg ccgagggaac
     6901 gcagcgcggt ggggacctgc tcggcgccga cgcggcgttg ctggacggag acaccgacct
     6961 ggcggagcag ggcccggcag gcgctggcgg cgccggtgat ggtgttgtgg tggaagtact
     7021 cctcggcccg gcgcagccaa gcgacgggat cgccccaccg gtcggcgtgg gcggactcgg
     7081 cgacgagccg gagcccgaga tggcgggcca gcgggaaggc ggcaccggcc tgttgggcac
     7141 tggccatggc gtcgcaggcc tgggcggagt cgccgtcacg gccgtgcagg acggcggcgg
     7201 cgagctcggt gaactgcagg ttccagcgca tgcggccggc gggagtgtcg gcgacttccc
     7261 ggtagtgcga ccagtcgtag cggcggtcga gcaccccgag caggaggtcg agaccgtggc
     7321 ggccggcgag gtggaaggtg gtgggggtgg cggtctcgaa ggccagcgcc tcggccagct
     7381 cccgcagggc cagcggccgg ttctcctcga gcagggcgca gaagacccgg gccaagccga
     7441 cggaaagcgg catctcctgg gacttctccc cgccccactg gcggaattcg gccagcgcgt
     7501 cgtccatctc ccgccgacgg ccctggtgcc cggccagggt ggccttggcc atcagggtgt
     7561 accggaccat cgatccgagc tggagccggg tggcggactc ggcgcaggcg tcgatccgtt
     7621 cggcggccag gctgaagtcg ccgccgagca cggtgtgcag ggcgagaatg gcgtcggcgt
     7681 tgtaggccat ggtgatcgcg ccgatccgca aggcctcctc gcgggcccgc tccaggctca
     7741 gagtgtccga agtggacagc cagtcgatcc cggccagccg catcacggca taggcccgct
     7801 gcaggggaag ctggtgctgc tcgccgagct gccgggcccg ctccagacat tcgacagccc
     7861 gcgagatgtc gtgctcacgg gtgatgatgc cgagcagttc ccacgcctcg caggcgacga
     7921 cgggctgctc ggaccgctcg gcggcggcca ccgcccgcag ggccagctcc tcggcccgga
     7981 tgaggcgatc gggcctgggc atgtccattt ccacatacgc cgcaacgaca tccacccggg
     8041 cagtgtcctc atcggacgga agcgggccga gcagcgcacg cgcggccgcg acctgctcgg
     8101 ccccgtcggc cgaccgcccg gccaggtagg cgaccttggc cagccgggtg tgcagggctg
     8161 cccgccggcg cgcgtccagg ccgtcgccgt cgagatcggc cagcttgccg gcgagctgga
     8221 aggcccggtc gaagtgcccg gcctcggcca gtgccggcag cagcgactcc aggatgtcgg
     8281 cccggatgcc ggcgtccagc cgtcgggtca gcagccggtt ggccttgtcc agcaacgtga
     8341 tcgccgaccc ggcggccccg tcgcgcagcg cccgccggcc ggcctcggcg aacagccgcc
     8401 cggcggcggc gtcctcgccg gcgtccagcc gcagcgacgc caccagctga caccagtgtc
     8461 cgggcagctc aggatgcagc tccagcacgg catccgcggc cttcgacgac agctcggccc
     8521 ggtcgagcgg agtgagctgg ctcagcaggg cctcggcggt gagcggatgt cggaacgcgt
     8581 accagtccgg ggccggctcg tccggcgtga ccagctgggc ggccacgccg gcgtgcagat
     8641 gggaaagcag cccgcggtcg tcgatgtcgg cgacctcgcg caccaccgag agcgggaacc
     8701 ggtgccccag cacggcggcc accgacagca ccattcgccc ttgcgggcca aggcgatccg
     8761 tccggttggc gatgctgcgg gccaccgcgg ccggcacctc ggtgcgcagc gcgccgacca
     8821 cctgccagcc ttcctcactg ggcaccagca ggccgctgtt caccatgccg tgcaacagtt
     8881 cctcgaccac gaacgggttg ccggcgctgt cggcccacag ccgctgcacg acgtcgtcga
     8941 cgacgtcggg tgcgggaatc tccaggcagg aagcggccat cgcgcgcacc tgggtccggt
     9001 ccagccggcg cagctccagc agccggctgg tgcgccgctg ctcgccggcc cgggccaggt
     9061 ccagcgccgc gcccggttcg ctgcgaatgg tggccagcag catgatgggc tgaaattcca
     9121 gattgtcggt caggtactcg acgaccgcca gggtctcggc gtcggcgtcg tgcagatcct
     9181 ccagcaccag caggcatccc cggtcgcggc cggccaccgc gagcagtcgc agcaccgcct
     9241 cggccagcac caccagcgag gccggcgagg ccggcgcgtc cccgccccac tccgggatca
     9301 gccggcccag cgccggtcgg tacggcccga gctcactgtc cgcaaaggac tccccgccgc
     9361 ggaacagcga tagcagggcc tcggccagcg gccggaacgg caccatcggc ccgatcgcgc
     9421 tgccccgccc gcgcagcacc cgcatgccgg tgtcgaacgc ccggcccgcg atcatcgcgg
     9481 ccagccgtga cttgccgatg ccggcctcgc cgaccaggtt cgccgaccca ccccggccgg
     9541 cccgcgcacc cgacagcgcc cgcgtcagct cgaccagctc ggcatcccgg ccgaccagga
     9601 gcggcgcgcg ggtctgcatg gtgccagacc ctatgccggg tcgctcggaa ttccatgaga
     9661 agtgcccggg tatggccgaa taccgggctg gtctgcccct aggggtcgac cggttccccc
     9721 atccgggcac accggatgag ggaaccggcc gacacgcggt cagaacaact gaccgggcgc
     9781 gctgaccgtg gtggacggaa cggcggtgat cgccatgaag gcgctcatcc ccaacgtcag
     9841 gccggccaga gcccgcgctc gcgcccccgc acgcgttctt gcgttcacca cgatctgccc
     9901 cgccgggttc tcgccactgg cggtggcgga ctcgacgtcg ttctcgggtg cggtcatctc
     9961 ggtcatttcg gtgactcccc tcagtggcac aacggaaaat tcagtggccc gacggttcga
    10021 gcagcagcac cgacggcacc cggccgggca gacccagccg cagcaggccg tagccgatgc
    10081 cggccagccc gctgagcagg ccgggcgtgg gcacctcgcc gggcgtgccg cagcgcgccc
    10141 cgtactggtc gagcgagccg agcacgaggc cggcacggcg gacgacggcc gcagcggccc
    10201 gctcgtcccc ggcccggccg agcacgatga gcgcctccat cgcgccgagc tcaccgtggc
    10261 acagactcag gtcccgcagc ggagaacgtc ccgcgagggc gtccacccag ccggcaaggc
    10321 gctcgtccgt acggccgatc cgcgccagca tcgacccggg aaggccggca caccaaccga
    10381 aatcccccgg agcggccgga tccccttccg ccgcaaggta gtccaggcca acggcctcgt
    10441 gccggtcgct gccgatcgcc gacgccagcc gcagcagcgc ccaccccacg cccgccgggc
    10501 cgcgggcgaa accgaccgtg tcggtggtgg cgtgccggcc ggtggccagc cggtccgcgt
    10561 agcggatggc cagcgtgccg gcgctggcca ggccggtctc ggcgtgcacg gcgagcatcg
    10621 ccgccagccc gccggccagg ccaccggcga tgtcggccgg ctcgtcgccg gcctcggtct
    10681 ccagcgccgt ggccaaccgg accgcccggg ccagccagcc cagcacctcg gcgtcatcgt
    10741 cgagcaggcg gtgcagccgg gccagcgcgt agcagatgcc gcccaggccg tggaaaccgc
    10801 cggagccgac gtccatggcc agcgccaggt cgtcgcccag cgcgtcgagc agccgcggaa
    10861 tcggccggat cgcccgccgc gccaggtcgc cgtagcgggg cgcgccggtc agctcggcca
    10921 actgggccag gaacagcgcc agccccggat agccgttggc cagtcccgcg cccatcggca
    10981 gcaccgtcca ctgccggtcg tccacgagtt cgagaccgag ccagttggtc cggtcaaggc
    11041 ccggcacggc ccggccgacg agctcgtcgg cgatgccgca ggccgccgcc accagccgct
    11101 gcggatccgg cacgaccgag gccaccgccc ccggcagcac ggccgcgccc cggtgcgtga
    11161 ccggctgcgg ccgggtcgcg aacgaagccc ggatcagcca ttcctggttg tgccggtcca
    11221 cctcgcccat gtcggccagc ttcgcctcca cggcggcgag accggactcc gcgagcagcc
    11281 cggacagccg aaccccgttg gccgaccaga catcccgggt ccccacccgg gtggtgaaca
    11341 tcggcacgtc gccggcccac aggtcggcga tctcatgcgg caccagacgg cggcgcatcg
    11401 ggtcgtccag cgagtccgtc cacagcagat cgaacacgct gtcccggtcc agcgcgtccc
    11461 gcaggacgtc cgggtgcgtc gactcgtcca gcagcgtcgc atacagctgg gtcgggcggg
    11521 ccacgaagcg cagctcgtcg tcggcgcacg cgcgcagcag ggccaccagc tcgccccggt
    11581 gctcgacgat cgcgtcgtag cccgcctgga acccggtcag cagcgccgcc tggtaatccc
    11641 gcggctcggc ctcccgcctg ccgagccgcg gccggtttcg cccgcctcgc atcgccaccg
    11701 gccggcgcac cagccgcatg gagtcggtgc cggcgccgtc ccaacccacc ccatcggtgg
    11761 ggaagacgcc ctggtcaccg cccaggccgg agatgtcgag cgagccgttc tcgcccagca
    11821 tcacctgcgg cagcagggct gtgcggaaca ccgagcgcac cagttcctgg gcggccgggt
    11881 cgggcccggc cgcggtgtcc acccgcatcg tcggatggca cagcgtctcc acgtcgatca
    11941 gcaccggctg gtcgccgtgg gcgatcaggt tctcgtagtg catgtcgctg ccgtcgacgg
    12001 cgtacagcag ggccagcagc gcgccctgcc gacggtagaa ccggctcagc ccggtcacct
    12061 cgtcacacgg aacggcggcc acgaactcct gccagccgta gccctcccgg cccaacagcg
    12121 tgaccttgcg caggccgagg ctcggcacgc ggccgttgag ccagtccagc atgtcgttga
    12181 agtgggcgtg caggtccagt ggacgcggct tgtagacgac ggtgcgcccg tcggcgaacg
    12241 tcagcagggc aaccgagcgc ccgtgctgat gggcgtctcc ctcggtggac tcgatggcgg
    12301 ccagcattcc cgggtcacga ccgtcgagca gcgtctcgat gatcgtgtcc cggtcggatg
    12361 ccaggcgctc caacaactcc aggtgggcca gcaccgcctg ctggcaggcc tgcgccagca
    12421 ggcgggccaa caccgggtat tcggcgaaca gcgcgtcaag gtcggggcgg acggcgaact
    12481 ccgcgaaccg ctcctgcggg gtgcggccgg ccaacccacc ccgagttcgg gccagattca
    12541 gctccagcac cagcgttcgg gcggccagcc gggccagccg acggcccagc cggtgcgcga
    12601 aaccggcagt cacctcgggg cacgcggcac tggcaactgc ctcttccgcc accgacacca
    12661 gcggccgcaa acccgcggcc agcacgccga tccagtcgtc gccgaacgcc ttgcggcggc
    12721 cgctgggcgt ggtcagcgcc gagtccacga agtcggccca acccggccgg gccacccgcc
    12781 gcgccagcgc gtccggggcc tcggccagca ggcccgtcaa cagcttctcg tccagtccca
    12841 ccgccgcgag tcgccgctcg aaccagtccg gggccagctc ctcgtgcgcc cgccgccacc
    12901 gctccagccg cgccagcgcg gtcgccgtgc cgccgagcag ctgcgccgtc cgcggctgcg
    12961 gcgacgtgcg gggcagccgc tcgtgcaggg tcaggccccc tgcccaccag aacgtcgccg
    13021 acttggtcac ggccggaacc gtgccaccgc accccaccca gccacatggg ggcacggccc
    13081 ccatatttcc caggccgtca cacagagggg tggcagcggg ggcggacggg ttgcgggagg
    13141 gcgacgatgg ggcaaacgga gcagcgggag gaaacgtgat ccgggctggg atcgtggcac
    13201 tcgcggtggc ggtgctggcg gcgggcggtg ccccggcggc attcggcggg gcgcgcggct
    13261 gcaacaaacg gacctgcgtc gaggtcgacg gcagcgggct gcacgtcaac tacatcgcgg
    13321 cctcgacgac gtggaacggg gacttcagcg ggcactttca tatttggggt ggggggatcg
    13381 accagaacag tggcaccggg ttttgggggt atcaccaggt gtacaaggtg ggggttggtc
    13441 gggatctgcc gaatcgggcg gtggtgtgcg ctgaggggtg ggaacatgct ggggggcggc
    13501 tgaactccat ggggcgggct tgtgaggaga tcaagttcta gaggggtttg gggaattcgg
    13561 ccgggggtgg gctttggggt gcgatttttg ggtgggattt tttaggtttc tccgggtgga
    13621 ttttgcgtgg agcctctggg tgatggcagt cgaggcaaag aagcgggcag gctgcgcctg
    13681 cctcgatcgc cgacagctta tgccatcgcc cccctccacg caaaatccac cctccgaggt
    13741 tttgggtgag ggatgcttcg ggaattccgt gttggcttcg ctgtggagtt gtcaaagaac
    13801 cggcgctcag tactggtggg gctgagtcgt gtaatggcgg ccttgcgggg tgtgccagtg
    13861 cagggttccg tcttcgtcga gggttgccgt gtagtcgcgg tgtttgaggt ggtgatggtg
    13921 ggcgcagtag cccttgagtt gggtggcggt ggttttgccg accggccagg gggtggtgtg
    13981 gtcgagttct tggatggggg tggtgcagcc gggggcggtg caggtgccgc cgtcgcggac
    14041 tttgatgaac tcgcgggtcc gggtgtcggc ccggtatttg tgggtggtca tggcgtcggc
    14101 gtggcggcgg ttgtcgagga ggatgccgcg ccaggggccg tgcatggcca gttcgcgggc
    14161 ggagtcggcg gcgatggggc cgtagccgtc cagaaggccg gggtcctcgg tcaatcccat
    14221 caaggtctcc accgggatgg tgacgtggac ctggacggtg cggtcgacgc cgtagcccag
    14281 gaaccggtca aggaaggcgt cggcgcgttt ctggtcggtg gtgcggtcat ccttgactag
    14341 agcccgggca tcttgcgtga gcaggtcgta ggcctggcgg gcgtcgatgg ccggcaggat
    14401 gatgctgagc tgggccatgc catcgggcag gggagtgaac tcgacccgtc gatcttcccg
    14461 ggctttcagg cggcgttggt cgtagccgag tgggttggct tcggcgactg ctttggtggc
    14521 gcggcgggcc agttgagtgc gagtcaggcc aggggctact tccgccaggg tctcatccac
    14581 ttgggcgacc agctcggggt cggtcaggtg aaccactcgg tcgtcaatgg tcttgagccg
    14641 gcgggggtcg atctcgcccc gccgtagcag ttccgcgcat tgggggaggc ggtccaggac
    14701 gtcgctgtat tccttctgac ggaccaccga ctgctccgga tcatgaaccg ccatggcgat
    14761 ctcggccgtg tcctcgatcc cccgaaccag gctgagctca acgtagtgca gagccgccat
    14821 caccttacgg gtcacgataa gcagagtgag cttctgatca tcggtaagac tctccacgtc
    14881 cacacccagg agcaggtcca ccatgacccc tgagggttcc atggactcca actctcgggc
    14941 gatttccttc atgtctccac aatactcgca aacatgatcg aactcgactc actaatgggt
    15001 gaattcggca ggcttaaccg gctcacccca aggaccctcg ccccttacct cggagggtgg
    15061 attttgcgtg gaggggggcg atggcataag ctgtcggcga tcgaggcggg cgcagcctgc
    15121 ccgcttcttt gcctcgatgc catcgcccag aggctccacg caaaatccac ccggagcaac
    15181 ccaaaaacct acccgctaac ccctaagcat tctgtgcccc gttgtaaacc tgccaagccg
    15241 catcccgata gtaagcaaag taagagtccc cccagctccc gaagaagctc cccgtctgca
    15301 tcgccgtccc atcaccctga tagttcacga tgaacgcccc gccactggcc ccgccggaca
    15361 ggccgttgca gttggggatc tgcacgccgc cctgcggccc gtcatacggc tgcccctcgc
    15421 accagacggc gtagtccttg tcggccggga tgccgatgcc gtgcgcgtag ctgttgctgg
    15481 gctggttgaa gccgatgccg gagctgccga tggcgtcctg cacgtgtgag ttgttgttgc
    15541 cgccggtgct cagcacgatg aacgcgttgt caccgccggg gctggtgtcg tcgacacgcc
    15601 agcccatgga gcgccagttc caccagccgt agggggcgtt gccctggttg tacgagggcg
    15661 cgaaccggaa gttgttgtag gtctggccgg tgctgatgtc catcacgcag tgccgggcgg
    15721 tggcgatcac atcgcggttg ttgctggtca ccacgttggc cgtgcacagg tagtcgccct
    15781 tgcccggcac cgagaacacg agtcggccaa tcgtcgacca gacgctgctc atgggctgaa
    15841 accgggatgg gcctgaagaa atcggtgctg tgctgtggac gaacttcggc tcacccacct
    15901 gctcctgggt ggtgctccgc gcggccgtcg gggccggcat cggtttggcc gcggccaaac
    15961 gctgtggagt ccagtaggag tccagcgcgg cggccgactt cgtgttcgtg gcggtggccg
    16021 tggtcgcgtg cgcggggacg gtcgggacca gtagggacag ggcggcgagc aggacaactg
    16081 cggaggttct gagcacgatg tcaaccccgt tcgtagcggc gggtggaatc gtggcggccg
    16141 gaccatggtg ccagagcaat cggcgtaatc gttgtggcgc aggcgattcc tgtccggtaa
    16201 cggacatggg ctgtccgcga tatgcctccc gtggtgttcc gacgtgcctc cgagctcggc
    16261 gaccggctgc tggagctgtc ccggttcaag tatccgcccg acaccatcgc gctggagcac
    16321 ggcgcccggc tggccggcta cctggacgac gatgagagtc tgctggaagt ggtgcacgcc
    16381 cgccggtcct tcggcgcgac tgtcgcatgt ggactcgtgc tcaccggaga gcgcttcatc
    16441 ttcatgccgg agacccgtca cctcggtgag gtgcgcaaga tcctgcccgg cagcggcggc
    16501 gcgttcgggc tgccgctgtc cgcggtgacc gccgtgcgca cctccggcca gccggaggag
    16561 accgactggt tggaggacct gttcacgcac cagtcctcgc acgccggcct ggtgatcgcc
    16621 gcccgcggcc tcggcgagct ccacttcgag tccgtcgtcc cggtcgacgg ccccggccgg
    16681 gtcgtggacc gggtgcggga gatgggcatc cggggctgag atccgcggag acgagaatgg
    16741 ggacgacaac cgtccccggg aaatcagctg gtcagatttg cgaagttccc ggcgggggct
    16801 gtgtttgtgg gtgttcctat gtgagcatcc gtcgcggtct gtggaacctc cccgcctgtg
    16861 ccgggaattc tcgccgcagc ttgaccgtgt cgcaggggtg aaggtgcggc gctgttccgg
    16921 tcggagcggt cattcctgcc gctggacgag ttggccgccg agattgtcgc cttcatcttc
    16981 gccgccggca tttaccggcg gcttggcatc gatacctcgg tcaccgacat atctatgcca
    17041 aacgggcgcg tgagcatccg atcgccgtac gtctcatccc gccggtcggc caggtctggc
    17101 cgcacgcccg aacgaatggg ctattgcgga attcctcgtc ggcgacgtct tccgtcgcgg
    17161 ccgacgtccg ttggcgcgcg gaccagcgcg catcggttcg ggaggaagtc gggcctctgc
    17221 ggcaccttgt ctggcacaag ttgacgttgg tctgattcgg ttcacctccc gtttgcctac
    17281 accgtttacc ttgcggtcct ccgatgcggc aggaggcgcg gatggatctc tcgctcctgg
    17341 tcatcgtggt catcgtgacc gcgctggcct tcgacttcac caatggtttc cacgacacgg
    17401 ccaacgccat ggccacttcg atcgccaccg gggcgctcag ccctcgggtc gcggtcggcg
    17461 tctcggccgt gttcaatctc gtcggcgcgt tcctgtctgt gcaggtggcc aagaccatct
    17521 ccagcggcat cgtggacgag gccaagatca acagtgccat catcttcggc ggcctggtcg
    17581 gcgccatcgt ctggaacctg ctgacgtggc tgctgggctt gccctccagc tcgtcgcacg
    17641 cgctgttcgg cggcctgatc ggggccacct ggatcgccgc cggctccgac gcggtgcact
    17701 tcgagacggt cctcgagaag gtgatcgtgc cggccctcgc ctcgccgatc atcgccggcg
    17761 tggtcgccac cctggccacc tgggtcgcct acaagatcac cgagaaatcc gacaaaacgg
    17821 agcgggccaa gggcttcaag gccggccaga tcctgtcggc ctcgctggtc tcgctggccc
    17881 acggcaccaa cgacgcgcag aagacgatgg gcgtgatcac gctgaccctg atcgccgccg
    17941 gcacgctgcc ggccggctcc aaccccccgc tgctggtcat cctgggctcc ggcctggcca
    18001 tctcgctggg caccttcctc ggcggctggc ggatcatccg caccctgggt aagggcctga
    18061 ccgagatcga gaccccgcag ggcttcgccg ccgaggccag cgccacggcc accatcctgg
    18121 cctccaccca ggtcggcttc gcgctgtcca ccacgcacgt ggccaccggc gcgatcatcg
    18181 gctccggcgt cggcaagcgg ctgtccgagg tccgctgggg cgtcgccggc cggatggccc
    18241 tggcgtggct gttcaccctg ccggccgcgg ccatcgtcgg cgccatcgcc ggccggaccg
    18301 cgtcgctggg caacgtcggc accgtcatcg tggctgtcgc cgcggtggtc gtggccgtcg
    18361 gcgcctacct gctgtcccgg cggcagccgg tgtccgccgg caacgtcaac gagatgccgt
    18421 ccaccagcgc cccggcgacc gcgtcggcct gagcagggag aactccatga ccatcaattg
    18481 gggtggcctg ggcgaggtct tcgtcgtcgc cattgtggcc tcggtgcttt ttgtcggcct
    18541 gttctcggtc ggcatcggcg cgtggacccg gcgcggcgag gccgtgctga acaacgtgct
    18601 ggcgatcggg tgcttcgtgc tgtgcgccgt gatcatcggc tacggcatct tcgccatcgc
    18661 ccacaagtaa ggccgaaagc cgtggccccc ttcgcttttc ttcgcgaagg gggccacagt
    18721 catgtcagcc ggccgcgttc atcaggtcca gcgcgctctg ctggcgggcc gcgtcggact
    18781 ggtcgaacgg gcccgaccac accaggccgt actggtcgaa tccgttgcgg tcactggcgt
    18841 acgccgaatc ggcctggcgg ttcaggtacg tgctgtacgg gtggtccgac agggccgcgt
    18901 tcaacgccga cagaccccgg gcgtagacgc ccttgaaggt cgggccgtcc gcgccgccgc
    18961 caccgggctg gtcgcccggg tcgtgcagga ttccgttggg gttgagggaa acgctggtcg
    19021 tcgaggcgtc ggccagggtg cgggcctggg tgaggtagga gccgttgccg gtggcccggt
    19081 agagctcggt cagcgccgcc agcggcacgc cctggttgta gctccaggtc ggctggttgt
    19141 tgttggcgca ggtgctggtc agtccgtcgt tgaccaggtt ctgcccgttg atcatcccgc
    19201 tgttccggaa ccaggtccag ccggcctgcg cccgttgcag gtacgtggtg tcgccgggga
    19261 tcctgttgtg cagggcggcg ttcagctcga tgtagagcga gttggggatg gcgttcttgt
    19321 acgtcttggc cgaactccac cacactccgc cgccgcaggt ggagtcccag taggcgaaga
    19381 cgtggtcggc gtcgaagcgg gcggtggtga ggtagcggct gtcgccggtc aggtcgtagg
    19441 cctcgaccca ggccaggccc caccagagtg tgtcgtcgtt gtacgggttg gtgaagttgc
    19501 cgccctgggc cgagagattc ttgttgtacg tgttggcgat ggtgtaggcg tagctgccca
    19561 tgccggccac ccggatgttg tcgatgacgg cggtcagcgc gttggccgag ttccaccagc
    19621 cggtcgtgtc gaacaggccg gtggtgttgt tgtagtcctc catcaacgcg gtggcggcgg
    19681 cggtgcgccg gtcgtaggag ttccacgtgg tgcggcgcca gtcggtgcac gtgatcgtcg
    19741 aggaaccggc cggcagcgcg caggcccgca gcaggccgat gccgttgttg ttccagtcgt
    19801 cgacgttgaa catcagcgtg cgccagcccg gatagccgga cggcgtgcgg gtgtcgccga
    19861 tcttggaacc cgacgcccag ctgcggccgg cgtcgaagga ccggtccatc cacagttcgt
    19921 cgccggggga gctgttggtg atcgccgcgt agcccatgtc gtcgttgtcg tcgaggtaca
    19981 gcgagagctg gcggctgccg gccgccgtca cagtcccttg ccggctctgc tgcgccaggg
    20041 ccggatcgcg gccgtcgcag tacttgtcgc agatggtggc catcggcttc acggtgttgc
    20101 cggtcgacgg gggaggagcg gcggtggtcg gcgccggcgt cggcggcgct ccggtcgacg
    20161 cggcggcgac cggagcgagc acgacggtga gaacgagcgc gcacaaagcg gcggctctga
    20221 gcatggaacc tcccggacag caggggtttt accggtcgga acgtgctggt gagagcgctc
    20281 tcgaaggcga atgtaaggtc cgtgtgagct tgccgtcaac gattacgctt tgacgtatgc
    20341 gactgctgct cgttcggcac gccgagtccc tcgccatgac ccgcaacctg acggtcagca
    20401 acgacaattg ccccggcctc acgtcagttg gcttcgacca ggcccgtgag ctgggccgac
    20461 gactcgatgt ccggcccgat gtgctggtgc gcagcccggt gacgcgggcc cggcagaccg
    20521 ccgacgagct gatcgcggcg ctgcggccgc cgcgcacgga gatcgaccgc gacctggccg
    20581 aagtggacat cgacgagcca tggaacggat ttctgtctcg ggtggacaac gtcctgacca
    20641 cctggccgga gcgctacgcc ggtcagacgg tcatggcggt gacccacgcc ggcttcatgg
    20701 tgtgggtgtt catgaccttg ttcggcgtgc cgcgtcccgg caccggcgcc cgcgtcgact
    20761 tcgacttcgc ctccgtgacc gagtggcaat tcagtggcgg gtggcggctg gtgtccctca
    20821 atctgacctg atggagaccg aacgcctgct gctgcgcccg gccgaaccgt ccgatgtgga
    20881 cgatctgcgg gcgctggacg cggaccccga ggtgatgcgc ttcctcggca cggacggcgc
    20941 gagctcggtg gaactgatcg ggcggaccga ctactgggtg ggaatcgagc gcgccagtgg
    21001 ggacttcgtc ggctggttcg ggctggccga cgagctcggc taccggatcc gccgcgacaa
    21061 gtggggccgg ggctacgcca ccgagggggc gaaggccctg ctggacaagg ccttcgccga
    21121 gggccgggag cgggtcaccg cccagaccat ggccgtcaac acgggatcgc gccgcgtgct
    21181 ggagaagctc ggcctgcggc acgtgcgaac gttccatgtg gactgggaga acccgctgcc
    21241 cggctccgag cacggggagg tggagtacga gatcagtgtt tggccagctg ggacaggaac
    21301 agctccaccg cgtgcgcggt agccgcggtg cgggcgctgg gcagcgagtc gaaggcgtgg
    21361 tgggcgtagg gcagctcggc gtagccgata ggcgcgccga gctcccgggc ccgggtggcg
    21421 aactcgcgcg cctggttgac cgagacgacc tcgtcccggt tgccgtgcac caccagcagc
    21481 ggcggcgaat ccggggttat ccggtggatc ggggaggccg ccgcgacgtc ccgctcctcg
    21541 tcgatcatca cccggcggac gtggtcgcgc agcccgctgg agccgtcctc gttgcgggcg
    21601 tccaggtcgt agaccccgta cagcggcacg ccggcctgga tcgaggtgtc ggcgtcctcg
    21661 aaaccgggct ggaaggcggg atcgttgccg gtgaccgcgg ccagcgcggc caggtgcccg
    21721 ccggcggagc cgccggtgat cgcgatgaac gacgggtcgc cgccgtagcg ctcgatgttg
    21781 gcgcggaccc aggcgatggc ccgcttcacg tccacgatct gcgccggcca gcggttcttc
    21841 gggcccaacc ggtagtcgat ggccacgcac acccagccgc gatcggcgag gtgggccagc
    21901 agcggcaggt tctgctgccg gcggtcgccc gaggtccacg cgccgccgtg cacctggatc
    21961 agcaccggcg cgccggtgac ccccggcttg cgccacacgt ccagcacctg gtcgttgccg
    22021 tagcccacgc cctcggcggc gatgaactcc ccgcgccgga acttgcccgg ccacgcgggg
    22081 gtcggggcgt tcagcgtcac cgtgccgtgg ccgagcacct cgtccaacgc tccctggaga
    22141 tgccggcctg tctccgccgc cggtcgctgc aacgctgcca gccccaccgc cgcgccggcc
    22201 gacaccgcca gcgccgccgc gccgatcttg ctgcggcccg cccccaatgc cgccgccacg
    22261 ccggttgctc ccagttgcgc cgccgccacc ggcaccgaca gctcggtggc gaccacgccc
    22321 gccgccatgc cggccagatg ccacggggcc cgccgccacg gcgttcgcct cgcgaacacg
    22381 ttcaacgcca cgccgccgac acccgcggcc accgccagag cgatccccgt cctcgtcacg
    22441 atcactcaac gaagcaaact ccggcgaacg ctgctgctga ggagtgaaac cgatcacaca
    22501 accgcagatg cggatctatc ctggcggatg tgacgccgct gcggcccgat gagctggtca
    22561 tcaccggcga ggtcgccacg ccgggcacgg tgtggtgcac ctcggcgctg cacgcccgcg
    22621 cctgccggcc catcactgtc gactacgtga ccctgcgccg caccgaacgc cacgaggtcc
    22681 gtggtgtcac cctctacgaa gccctcgccg ctgccggcct cgccctcgac cccgcccgca
    22741 agatggacca cctcagcctc gctgtcctcg ccgagggcgc cgacggctac ggcgttctcg
    22801 tctcgtacgc cgagctgcac cccgagttcg gcgactgtgg cgcactgctc gccacctggc
    22861 acaacggcca actcctggcc cgccccaccc tcgtcatgcc ggccgaccgc cgcgccagcc
    22921 gcttcgtccg ccaggtccac cgcctccacg tcgtccatcc cgtggccgcc cagaccttct
    22981 gacggatctg cgcattcgcg aaataaagaa aagaccgtgg actcgccttg
//
