LOCUS       NZ_CP073318            25915 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 418284
            Orig. end                         :: 444199
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25915
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="3"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..25915
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25915
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:15915](-)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..15915)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(482..1822)
                     /locus_tag="JJ691_RS01870"
                     /old_locus_tag="JJ691_03740"
     CDS             complement(482..1822)
                     /GO_function="GO:0016758 - hexosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF021134.4"
                     /locus_tag="JJ691_RS01870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03740"
                     /product="glycosyltransferase 87 family protein"
                     /protein_id="WP_211767056.1"
                     /transl_table=11
                     /translation="MSDVKTTRGFWTRVADSFLPTPTEGAQCHQPRPLTVPVWLRRATP
                     WVIVAVLAWFAVCTVIWPVGMWMQIDLEVYRAGGLTVLDGQSLYAHPLVASLMFTYTPF
                     AAIIFAPLALLPLVGTEIVYSVVTVLLLLFAVARCWRWMGYRRDRAAVGVVLLGTALAL
                     MFEPVRTTLYLGQINVLLLAIVVADLLRTRKSNWTGIGVGIAAGIKLTPLIFIPYLLLT
                     RQFKAAGVATASFVGTIALGFVLKPADAYAYWVRQKFSEVARVGDVWSTGNQTLRGFLA
                     RLVSPPEATQNIWVLLAAVIGVLGLAAAVLAHRRGEELLAVSLVGLCSTAVSPYSWSHH
                     WVWFVPLFVFALHRALTTGRAAMWVLTAYVLITAFAWPVSWPVHDPTARASTGIWMIDW
                     PGDIVTRNEYLIAYLVTAVFTLVHLRRSKVVASTDGVIDNRNPVASR"
     gene            2018..4297
                     /locus_tag="JJ691_RS01875"
                     /old_locus_tag="JJ691_03750"
     CDS             2018..4297
                     /GO_function="GO:0004144 - diacylglycerol O-acyltransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glyco_tran_28_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF018657.4"
                     /locus_tag="JJ691_RS01875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03750"
                     /product="WS/DGAT domain-containing protein"
                     /protein_id="WP_211767057.1"
                     /sec_met_domain="Glyco_tran_28_C (E-value: 1.3e-08,
                     bitscore: 34.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLDSATPRRILILSADMGEGHNATGRALRAAAGRLWPDASTHWLD
                     TLDVMGRGVGPAFRRIYVTNVERTPWLYEFFYNSVWRYRWFATASKRFVGEWAGRRLAA
                     RIDQIQPDLILSTYPLGTAGLDWLRRHRGLEAPIGAWVSDFAPHPFWVYQGIDLNLVMH
                     EVAVPVAARSAPGATVAISAPTADEVFRPGDRAAARAELELPQDTFVSLVACGSLGFGR
                     SEDTVQELLVGNPDGLVVVVCGRNERLRARIRAAIGDDPRVRILGWTDQMSTLMVAADV
                     VVTNAGGATSLEALAVGRPVLMHRPIAAHGRANAQLMADAGIAVVCRRDGELAEAMRDL
                     PRLAQMEQLALKQADERLVEEGLLALNSTRPERLGRVLSAEDSLFVHIASPRVPQHVGT
                     IMEMSGEVSVDDVAGMLDAMHGVRGHVDPGSWLRRPRWTQDEAVEAKALVSEVDGVSLR
                     EAVDSFYARPLPAGATAEALIVHGSSPAVLIKLHHALGDGVAVLRGLLGGTSGKGRAWA
                     SPVGHQVSHKLPRLRLKGLLALARAGAVPRGPKFGASRRLGLVKLPGAEVRATARGLGV
                     TPTELLLAMFALAYQGDRLRVMVPWSLRGTDTLRAAGNWTGALSVDLPVQETDPLRCLE
                     LVRDALRAGVESGAPEAANFVVRLIGLLPAPAHRLLARLVYQSRWFGAIASVIPGPRWQ
                     VLLGGAEIEAAYAVLPLAEGVSIAWGALTWGPHVTVCVTGGGAVDGSSLAERMVDALRE
                     FSGRTP"
     gene            4294..5157
                     /locus_tag="JJ691_RS01880"
                     /old_locus_tag="JJ691_03760"
     CDS             4294..5157
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154306.1"
                     /locus_tag="JJ691_RS01880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03760"
                     /product="DMT family transporter"
                     /protein_id="WP_211767058.1"
                     /transl_table=11
                     /translation="MNLIIAVPAAVGGAAFFGLTSALQHRATQQVRRREALEPGLLVDL
                     AQQRVWLLSLVANAFGVILQWVALTTGPLVLVQPLLVTGLLFGVLFSGSFDRVVLLGAG
                     LCVAGLAAFLLVAQPSGDSTGMTLGAVLPLAIGLAAILAICLAVAAHRPGNTRSLALAV
                     AAGVLYGVSAGVAKLAAEQLSQGILVLLTHWPIYAVAVCGPIGFLLSQNAFQAERALAP
                     ALAVITILDPLVGIGIGILWLGEDLRSGVGPVIGQVLALLALCAGVFVLSRRAPQTVAK
                     EAECPR"
     gene            5195..5899
                     /locus_tag="JJ691_RS01885"
                     /old_locus_tag="JJ691_03770"
     CDS             5195..5899
                     /NRPS_PKS="Domain: PKS_KR (61-164). E-value: 9.3e-10.
                     Score: 30.6. Matches aSDomain:
                     nrpspksdomains_JJ691_RS01885_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005452329.1"
                     /locus_tag="JJ691_RS01885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03770"
                     /product="SDR family NAD(P)-dependent oxidoreductase"
                     /protein_id="WP_211767059.1"
                     /transl_table=11
                     /translation="MPAVTGMRALVTGASSGIGAATADVLAAKGATVLRTSRTITGPSS
                     FACDLATGVDPLVAWAGDVDLLVLNAGLGHAGPFADMPPARIPELFTVNVVSQLQLARA
                     LLPGMLARRRGHIVLVSSIAGAMGVADEAVYSATKSALRAFADALRLEVRTVGVTVIHP
                     GVIDTPFFDRRGTPYTRRRPRPIPPVDVAEALVAAVEHNRPEIFVPSWLRFPARLNGVL
                     PALVRTLQRRFG"
     CDS_motif       5222..5290
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS01885_0001"
                     /evalue="1.10E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="JJ691_RS01885"
                     /protein_end="32"
                     /protein_start="9"
                     /score="14.9"
                     /tool="antismash"
                     /translation="LVTGASSGIGAATADVLAAKGAT"
     aSDomain        5378..5686
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS01885_PKS_KR.1"
                     /evalue="9.30E-10"
                     /label="JJ691_RS01885_PKS_KR.1"
                     /locus_tag="JJ691_RS01885"
                     /protein_end="164"
                     /protein_start="61"
                     /score="30.6"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GDVDLLVLNAGLGHAGPFADMPPARIPELFTVNVVSQLQLARALL
                     PGMLARRRGHIVLVSSIAGAMGVADEAVYSATKSALRAFADALRLEVRTVGVTVIHPG"
     CDS_motif       5540..5644
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS01885_0002"
                     /evalue="3.90E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="JJ691_RS01885"
                     /protein_end="150"
                     /protein_start="115"
                     /score="13.0"
                     /tool="antismash"
                     /translation="HIVLVSSIAGAMGVADEAVYSATKSALRAFADALR"
     misc_feature    complement(6076..6091)
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 23.15"
                     /tool="antismash"
     gene            6206..7447
                     /locus_tag="JJ691_RS01890"
                     /old_locus_tag="JJ691_03780"
     CDS             6206..7447
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013678518.1"
                     /locus_tag="JJ691_RS01890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03780"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_249227620.1"
                     /transl_table=11
                     /translation="MDTPLIRSLRAAVEAVPGDVTLRLHLAEQLLAVGDAEGAAEQAAT
                     ALQHDPASQAARAVLGRALGAPGEQVRQPQPVEAQQESGGEPEEPEGSQPDEAEAEPEK
                     VEPVPVFDWAAAEEDLGFLDVEEGRITLKDVGGLKAVKERLEAAFLAPMRNPELRKLYG
                     KSMRGGLMLYGPPGCGKTFVARAVAGELGAKFISVTLSDVLNMYIGQSERNLHEMFETA
                     RRNAPCVLFLDEIDALGQKRSQLRSSAMRGTVNQLLVELDDVRDSNEGVFVLAATNHPW
                     DVDSALKRPGRFDRTLLVLPPDLEARQAILAYHLKDRPTEGIDLGKLAKRTDGYSGADL
                     AHACEAAAEKALLDSVRRGQTRMIGMADLEEALKEIKPSTVPWFSAARNVAMFANEGGT
                     YDELLAYLKKHRLA"
     gene            7448..8455
                     /locus_tag="JJ691_RS01895"
                     /old_locus_tag="JJ691_03790"
     CDS             7448..8455
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1272: TPR
                     repeat-containing protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF024824.4"
                     /locus_tag="JJ691_RS01895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03790"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_211767061.1"
                     /transl_table=11
                     /translation="MDSIGRARTLIDLGRHEQARVELGKVLADDPASTEAWCLLAQCEQ
                     KAGDVNAMRYAAGQALASNPDSEWAHRLQSLALHKLGRHEEAIEAAREAVRLAPHQWQQ
                     YVVLVTAMIPRLDLYRAEATWAADRSVELAPQHAETHLTRGVLAGAQGNLVDAERNYRE
                     ALRLDPENAAARNNLATIQLRGNDLEGATAGFAAALAENPRLQVARDNIDLVCRRILRG
                     ARLAAQAVFVGAAFITLSSEGGPALPAVVAGLLVVFWAVMVARLVRRLAKPVRAHLRSQ
                     LRHERRHIPIMLVTAVYIAAALAAAWMPVQLVTSGILATVVYMVSERLRRPKAA"
     gene            complement(8462..9472)
                     /gene="hpnH"
                     /locus_tag="JJ691_RS01900"
                     /old_locus_tag="JJ691_03800"
     CDS             complement(8462..9472)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009076658.1"
                     /locus_tag="JJ691_RS01900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03800"
                     /product="adenosyl-hopene transferase HpnH"
                     /protein_id="WP_211767062.1"
                     /sec_met_domain="PF04055 (E-value: 8e-17, bitscore: 61.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3e-08, bitscore: 32.6,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.2e-05, bitscore: 23.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNMPLHQSLRIAGYLLGQKLRRREKFPLIVELEPLFACNLKCAGC
                     GKIQQPHDLLRQRMPVQRAIDAIEECGAPMVSIAGGEPLMHPQIDEIVNELVRRKKYVF
                     LCTNAVLLRKWIDKFDFKPSRYFAFAVHIDGLQERHDESVAKQGVFEEAVAAVKELKKR
                     GFRVTTNTTFFNTDTPQTVIEVLDYLNDDLQVSEMMISPAYAYEKAPDQEHFLGVQETR
                     ELFRKAFADGRRRRWRLNHSPLFLDFLEGKVDFSCTAWGIPSYSLLGWQKPCYLMSDGY
                     AKTYRELIDETDWDAYGRGKDPRCANCMAHCGYEPTAVLATLGSLKQSLRAAVGR"
     gene            complement(9469..10008)
                     /locus_tag="JJ691_RS01905"
                     /old_locus_tag="JJ691_03810"
     CDS             complement(9469..10008)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005457353.1"
                     /locus_tag="JJ691_RS01905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03810"
                     /product="hypothetical protein"
                     /protein_id="WP_211767063.1"
                     /transl_table=11
                     /translation="MADPLVVATALRIERFALRRGLRGVPVTAVGMGVRHPSRLALPAG
                     AALVVAGLAGALVDGLNPGDLVVDDRSLALSLRGNGFVVHHGAVAFSDHLVGSAERAEL
                     AARTGALAVDMESAGLLALAGDRPHAVVRAIVDTPSRPLLGPATLGGGIAALRRLAAIG
                     PVLRHWAESNAKEVHQ"
     gene            complement(10001..11824)
                     /gene="shc"
                     /locus_tag="JJ691_RS01910"
                     /old_locus_tag="JJ691_03820"
     CDS             complement(10001..11824)
                     /EC_number="5.4.99.17"
                     /GO_function="GO:0051007 - squalene-hopene cyclase activity
                     [Evidence IEA]"
                     /GO_process="GO:0019746 - hopanoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="shc"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T2TS"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019809861.1"
                     /locus_tag="JJ691_RS01910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03820"
                     /product="squalene--hopene cyclase"
                     /protein_id="WP_249228179.1"
                     /sec_met_domain="T2TS (E-value: 2.8e-152, bitscore: 507.3,
                     seeds: 58, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALAKQKAIDHLVSLQDGDGWWKGELETNVTMDAEDMLMRQFLGI
                     REPVGTAETANWIRSQQRADGTWATFYGGPGELSTTVEAYTALKLAGDPADADHMVKAR
                     QFVLDNGGIEKTRVFTRIWLALFGEWSWDRLPVLPPEMILLPKWFPLNIYDWGCWARQT
                     VVPLTIVGSMRPVRPLGISVAELRTGRPAEPFEPALSWAGFFQRLDKVLHLHAKLPVKP
                     LRAYCIRKAIKWILARQEADGGWGGIQPPWVYSILALHLRGYPLDHPVLRKAFDGLESF
                     TIKENGSRRLEACQSPVWDTALAVTALLDAGVPPDDPTLKGAGNWLLDEEVTVRGDWAV
                     RRPSLPPGGWAFEFENDNYPDVDDTAEIVLALRRMAPDEPAVQRAVEWTVGMQSRDGGW
                     GAFDADNTRRMAEKLPFCDFGAVIDPPSADVTAHVVEMLAHEGLSGMQPAQRGVKWLLD
                     NQEADGSWFGRWGANHIYGTGAVVPALIAAGLPTAHPAIQRSVTWLEQHQNADGGWGED
                     LRSYRDKSWVGRGDSTASQTAWALLALLAAGERGPVTDRGVRWLVATQREDGTWDEPQF
                     TGTGFPGDFYINYHLYRLVFPLTALGRYLDG"
     gene            complement(11830..12837)
                     /locus_tag="JJ691_RS01915"
                     /old_locus_tag="JJ691_03830"
     CDS             complement(11830..12837)
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005439219.1"
                     /locus_tag="JJ691_RS01915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03830"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_211767065.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 4.1e-58, bitscore:
                     196.0, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTATLPRPVTTAADLVQPAMRRAVDTLNPSIRNVVSYHLGWIDQA
                     GNPTAKGGGKALRPALALLSAQAAGGTAEQGVPGAVAVQFVHDFSLLHDDVMDGDVERR
                     HRPTAWKLFGVPAAILAGDALLTLAVEVLQPAASPAATDSVTLAVQDLIAGQSKDLEFE
                     RRRDVTLHECVDMANGKTSALMRCAASIGAILAGAPAERVELLARFGMHLGLAFQLVDD
                     LLGICGAPEVTGKAVLADLKVRKKSLPVVAALTSGTAAGDELAARYLVEGTPADEELPE
                     FARLIEQAGGLAWAEAEADRQVAAAGECLDAVGAPEEIREALWQITHFVAERDR"
     gene            complement(12834..14159)
                     /gene="hpnE"
                     /locus_tag="JJ691_RS01920"
                     /old_locus_tag="JJ691_03840"
     CDS             complement(12834..14159)
                     /EC_number="1.17.8.1"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020658528.1"
                     /locus_tag="JJ691_RS01920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03840"
                     /product="hydroxysqualene dehydroxylase HpnE"
                     /protein_id="WP_211767066.1"
                     /sec_met_domain="DAO (E-value: 3.1e-15, bitscore: 55.8,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARVVVVGGGLAGLTAACELADRGLAVTLVEARARLGGVTFSFS
                     RGDLVVDNGQHVLLRCYTAYLDFLRRLGVAHHIEMQPRMTIPVQGADGRLGSLSRTALP
                     APLHLLGSLATYKLLSPVDRVRAAWAVPAMRRLDPDDPRLDEQSLGDWLRAHGQNDNTI
                     SALWNLITVAALNCDADEASLALAAKVFRTGLLDRSENCDIGVPAVPLSELHGEPALAY
                     LRAHGAQVRLHAAVKEIRRADNGFEVVTGEDTLAADAVVVATSADAAARLLPDTVTDDL
                     GHSPIFNVHVIFPRRVTDLPFLAVVGSPVQWAFDRTSVSGLTQGQYLAVSVSAASEWID
                     LPVARLRELFLPEIARVLPGAAGQVPTDFFVTKERTATFRQQPGSGRRRAAQRTGTPGL
                     VLAGAWTATGWPDTMEGAVRSGQNAARLLSEQLPATVSEVAR"
     gene            complement(14156..15028)
                     /gene="hpnD"
                     /locus_tag="JJ691_RS01925"
                     /old_locus_tag="JJ691_03850"
     CDS             complement(14156..15028)
                     /EC_number="2.5.1.103"
                     /GO_function="GO:0016767 - geranylgeranyl-diphosphate
                     geranylgeranyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnD"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009154299.1"
                     /locus_tag="JJ691_RS01925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03850"
                     /product="presqualene diphosphate synthase HpnD"
                     /protein_id="WP_249227621.1"
                     /sec_met_domain="phytoene_synt (E-value: 2.5e-56, bitscore:
                     190.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.3e-63,
                     bitscore: 214.3, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTALSVTIEAAYDHCEHVTGEQAKNFSYGIRLLPPLKRRALSAVY
                     AFARIVDDIGDGDAPAEQRLAGLNEVRERLHNLADLRDDPVAVALNDATLRFGLPLGAF
                     DELIDGCQADVLGTAYENFEDLRHYCRCVAGSIGRLSLAVFGSPDQARDSQLADALGVA
                     LQLTNILRDVLEDRRKGRIYLPAEDLRRFGCTLDLDADGNLVDNEDALTALLEYQGARA
                     EEWYTVGLRLLPRLDGRSRACCAAMAGIYHRLLARMMTRPWLVRSSRTSLPDWEKVLVA
                     ARSLAGSRP"
     gene            complement(15025..15915)
                     /gene="hpnC"
                     /locus_tag="JJ691_RS01930"
                     /old_locus_tag="JJ691_03860"
     CDS             complement(15025..15915)
                     /EC_number="2.5.1.21"
                     /GO_function="GO:0004311 - farnesyltranstransferase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene="hpnC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005465127.1"
                     /locus_tag="JJ691_RS01930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03860"
                     /product="squalene synthase HpnC"
                     /protein_id="WP_249227622.1"
                     /sec_met_domain="PT_phytoene_like (E-value: 4.4e-46,
                     bitscore: 156.7, seeds: 61, tool: rule-based-clusters)"
                     /sec_met_domain="phytoene_synt (E-value: 1.2e-42, bitscore:
                     145.3, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVDTPARPSWTTSLPQPPTPASPDVAALHRRAGSENFTVASLLLP
                     PRIRRRLLSVYAFARLVDDIGDEAPGDRNALLDKVERDIDRIYAGYVATDRLWAELTVT
                     VHECGIPRTPFDRLVQANRRDQQVKRYRTFDDLLGYCELSANPVGHLVLHVFDAMSPER
                     AALSDQVCSALQVLEHLQDVAEDRRNGRIYLPAEDLERFGVREQDLAASKANREVRALI
                     AFETQRTLRLLDEGAAIVGTLRGLARLAVAGYVAGGRATAAAIVNARFDVLTTTPRPRK
                     SRTVAELARSLGGGR"
     misc_feature    complement(16127..16142)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            16192..17349
                     /locus_tag="JJ691_RS01935"
                     /old_locus_tag="JJ691_03870"
     CDS             16192..17349
                     /EC_number="3.1.1.103"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1053: beta-lactamase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003071212.1"
                     /locus_tag="JJ691_RS01935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03870"
                     /product="serine hydrolase domain-containing protein"
                     /protein_id="WP_211767068.1"
                     /transl_table=11
                     /translation="MAAFSVDGTCDPAFAPVRDVLAAQLADGRQLGAAVAVRVGDREVV
                     DLWGGHADPDRAKPWLADTVVNIWSTTKGVVALAFHMLVDRGLLDPDAPVRKYWPEFAN
                     DSVLVRHLLSHRAGLAAFREPTTAEELADWNLMITRLADTRPWWEPGTASGYHALTYGF
                     LVGELIHRVTGSSVRDFVHREVAERTAADFRIGLSPADNGRAATLVQPPPADPAAFQAM
                     FAQLNPVALAVLTNPVVGPDQGNSAYWRAAQIPAANGHATARAVATLYGAFASGGVAGG
                     QRLLGAAQVERAREGQGSGVDLVIGDAGLGGRETELGLGLWLSGADGHYGPNPRAVGHD
                     GFGGSFGLADPEAGLAIGHVMNLMGNVIADDPRKMELIAAVYSCL"
     gene            17382..18599
                     /locus_tag="JJ691_RS01940"
                     /old_locus_tag="JJ691_03880"
     CDS             17382..18599
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009082806.1"
                     /locus_tag="JJ691_RS01940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03880"
                     /product="MFS transporter"
                     /protein_id="WP_211767069.1"
                     /transl_table=11
                     /translation="MFADLLRHRSFRWLTLGRGISFVGNAMAPIALAFAVLDLTGSVAD
                     LGLVVAARSVANVALLLAGGVLADRLPRAVVLQGSSLGAGISQALVASLVLTGTASVPL
                     LAVLGVVNGALSAAFLPASSALTPQTVPADLLRTANAASRMTRSVAMIAGGSVAGVLVA
                     AVGPGWGIAADALGFLLAAVCFMRVRVAEPARERSHVLADLRDGWTEFTGRTWLWVVVA
                     QFLFVNAINAGGLQVLGPAIADQTFGRTAWGLALAAETVGALVGGFVAMRWQPRHALAV
                     GVALVVLDAGPLVGLAVAPTVVVMVVTLALTGFGMEQAGIAWDVSLPHHIPADRLARVY
                     SYDAVGSFIAIPLGQVVAGPVAAAIGTQSALLAGAGITVLATVAALGSRSVRTLSSVPR
                     VPLSGN"
     gene            complement(18765..20762)
                     /locus_tag="JJ691_RS01945"
                     /old_locus_tag="JJ691_03890"
     CDS             complement(18765..20762)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013222766.1"
                     /locus_tag="JJ691_RS01945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03890"
                     /product="NPCBM/NEW2 domain-containing protein"
                     /protein_id="WP_211767070.1"
                     /transl_table=11
                     /translation="MSVRLRLAALGVAAATAAAGLALVTAPAAVALDNGLARTPQMGFN
                     NWNATHCSGDFNETMVKGIADLFVSSGLKAAGYQYVNLDDCWALPARDAGGNLVPDPVR
                     FPDGIKAVADYVHAKGLKFGLYSSAGTKTCNTAGFPGGLGHEKQDAALWASWGVDYLKY
                     DNCNNQGVDAVQRYTAMRDALAATGRPILYSLCEWGQNQPWNWATSVGNSWRTTGDIND
                     TYAKMLSIFKANIKLGQYAGPGHWNDPDMLEVGNGGMTDTEYRSHFSLWSIMASPLLIG
                     SDIRKATPATMAILTNKDVIAVDQDPLGVQGTELSNANGLHVISKPLAGGDRAVALFNE
                     NGTPATISTTAAAVGLPKALGYQLNDLWSHKTTETAGKISATVPAHGTAMFRVHAGGAW
                     WSNPPAVHTSADLPLPYPGAPALVQPGTTTTLTTTTTNDGVLPGLLGEVKLTGPAGWTV
                     KATSPTFHPVLPAGRDVSTKWSVSTPADTPPGSYPLHVSTTYYPGKSTSDYDLTVSVAA
                     PLTAGTTGLGDDPWLSADNGYGPVERNTSNGESKAGDGHPITLGGVTYAKGLGVNAPST
                     ITYYPAGHCSAVTATVGLDDEKTGAGSVTFEIWADGNKVADTGLIKRGDPAQSLHADVT
                     GAGLLRLIVTDGGDGNTNDHADWANAQITC"
     misc_feature    complement(20748..20750)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20846..21478)
                     /gene="pcp"
                     /locus_tag="JJ691_RS01950"
                     /old_locus_tag="JJ691_03900"
     CDS             complement(20846..21478)
                     /EC_number="3.4.19.3"
                     /GO_process="GO:0030163 - protein catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pcp"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013230445.1"
                     /locus_tag="JJ691_RS01950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03900"
                     /product="pyroglutamyl-peptidase I"
                     /protein_id="WP_211767071.1"
                     /transl_table=11
                     /translation="MTTVLLTGFEPFGGDAANPSWDAVELADVPGVNLVKQLLPCGFDA
                     SVTVLRKAVEAADPDLVIAVGLAGGREAITPERVAINLDDARIPDNSGRSPVDEPVVDG
                     GPAAYFTGLPVKAGVAALRAAGLPAAVSHTAGTFVCNHVFYGLMHLIATERPGLRGGFV
                     HVPYSSEMAVPDAPSLPLRAIADGLAVLTRTCVDTSDDLAVTGGTLH"
     gene            complement(21483..22448)
                     /locus_tag="JJ691_RS01955"
                     /old_locus_tag="JJ691_03910"
     CDS             complement(21483..22448)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017931.4"
                     /locus_tag="JJ691_RS01955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03910"
                     /product="DUF979 domain-containing protein"
                     /protein_id="WP_211767072.1"
                     /transl_table=11
                     /translation="MIDAEWLYWLCGLFFLAGAGFSYRRAQYGGAAFWALLGISFCYST
                     FVVNKTAPPWPLGVAVIVVAGLAGFGALGRTEIATTNQAERITAANTLRGKLFVPALMI
                     PLVALIFGTMIASITVHGKPLLATGTATLTGLGVGALVATAIGMVLLRPAGGLKLTLPL
                     TEGTRLLQAIGWAVVLPQMLAVLGLLFANAGVGTAVGTIVSSVLPKGSLLLAVIVYCLG
                     MALFTIIMGNAFAAFPVMTAAVGWPVLVQQFHGNPAIVFAVGMLAGFCGTLCTPMAANF
                     NIVPAVLLEMKDRYGPIKAQLPTAAPLLVCNIAIMYLMGF"
     gene            complement(22445..23134)
                     /locus_tag="JJ691_RS01960"
                     /old_locus_tag="JJ691_03920"
     CDS             complement(22445..23134)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017916.4"
                     /locus_tag="JJ691_RS01960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03920"
                     /product="DUF969 domain-containing protein"
                     /protein_id="WP_211767073.1"
                     /transl_table=11
                     /translation="MVVLIGVALVVIGFALRLNPMLVVTVSGIVTALLGGLNPVAILDS
                     FGTGFATNRSVTIYVITLPAIGLLERYGLQQQAARLIGKLRALTTGRLLAAYLLIRQGT
                     AALGLTGMCGPAQTVRPLIAPMALAAAIRRHGELTDRQVERVKAYSASSDTVGLFFGED
                     IFLAVGSILLITSLVDSTYHLKLDALQIAVWAIPTAVCAYLIHGARLLWLDRSLSRMTV
                     KQEVSAR"
     misc_feature    23134..23149
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: strong, score: 18.39"
                     /tool="antismash"
     misc_feature    complement(23174..23187)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 16.38"
                     /tool="antismash"
     gene            23490..24323
                     /locus_tag="JJ691_RS01965"
                     /old_locus_tag="JJ691_03930"
     CDS             23490..24323
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015104071.1"
                     /locus_tag="JJ691_RS01965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03930"
                     /product="serine protease"
                     /protein_id="WP_211767074.1"
                     /transl_table=11
                     /translation="MRKSVLGTLLGALLATTALTTPAATAAQPSTAPAVAAIDFSGTVA
                     LNDCSGSLVKLAGAPTSGPALVLTNGHCYEGGFLDPGQVLVNKSSSRTFTLLSPTGGNK
                     ATLRATKVSYATMTDTDITLYQLNTTYDAIKSSYGISPLEIATAHPTQGTAIKVVSGYW
                     KKIYSCNIDGFVYRLKEGDWTWKDSIRYTSSCNTIGGTSGSPIEDASGKLIGINNTGNE
                     DGERCTVNNPCEVDQSGNTTVHKGTNYGEETYLLAGCMTGSAVDLTKAGCALPKP"
     gene            complement(24337..25332)
                     /locus_tag="JJ691_RS01970"
                     /old_locus_tag="JJ691_03940"
     CDS             complement(24337..25332)
                     /GO_function="GO:0000976 - transcription cis-regulatory
                     region binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006351 - DNA-templated transcription
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1078: LacI family
                     transcription regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013226270.1"
                     /locus_tag="JJ691_RS01970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_03940"
                     /product="LacI family DNA-binding transcriptional
                     regulator"
                     /protein_id="WP_306291346.1"
                     /transl_table=11
                     /translation="MSVAVTIRDVARQAQVSVATVSRALTSPDLVRATTRERVLAVAAD
                     LGYQPNLAARGLITGKTGNIGIVVPDLNNPFFTGVLKGVQNQARMASHAVFVADSDEDP
                     AAEEQLVRAMAKQVDGVILCSPGIDEQQVRELAESTTLVLLNRRMRGVPAALMNSGSGL
                     RQVVDHLVALGHHRIAYLNGPRTSWSNKERRRGLRIAVQRHDVDLVDMGPFPPRYEGGL
                     QAADLAIAENVTAIVAYNDIMALGVLARLRDRGVRVPDDVSLTGFDDLMFGALCQPPLT
                     TVAMPVVPAGRLAVDLLLDRLANRDAEVRQDELDTQLIVRATTAPPARAG"
     misc_feature    complement(25627..25643)
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 22.0"
                     /tool="antismash"
     misc_feature    complement(25645..25657)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 18.7"
                     /tool="antismash"
ORIGIN
        1 actggtcggc tccgagcagt tcgcggtcgg ccgcgagcga agccagttcg tccacctgct
       61 ccggggtgaa cacgacgacg atctgctgat ccgccggcag cagcaggtaa agctccatcg
      121 gcaggcgttc ggcccggggg ttcacccacc actggtgcgg atgcacgccc agcagccagt
      181 cgccgtagtg cgggtggcgg caggggacgc cgaggctgtc gccttcgcgg agggcctcga
      241 cgaggtcgtc gatgtgccgg ccacggacgg agacggtgaa cacggcggcg tcgccgagct
      301 ggatggtggc cacccgctgc tggcggccgt gccggatggt ggtgacgacg ggggtgccgt
      361 cggagagccg gccgggaacg gtgaacattg ttgcccctca aagggttcga atgccgtggg
      421 ctattcgaac ccttcgcggg caaggggcct cgcggcccgt gcgccgggct tgggaccgac
      481 cttagcggct cgccaccgga ttccggttgt cgatcacccc gtcggttgac gcgacaacct
      541 tcgaacggcg taggtgcacc agggtgaaca cggcggtcac caggtaggcg atgaggtact
      601 cgttgcgggt cacgatgtcg ccgggccagt cgatcatcca gatgccggtg ctggcccgcg
      661 cggtcgggtc gtgcacgggc cagctgacgg gccaggcgaa cgcggtgatc agcacgtacg
      721 cggtgagcac ccacatggcg gcccggccgg tggtcagggc ccggtgcagg gcgaagacga
      781 acagcggcac gaaccagacc cagtggtgcg accacgagta gggcgacacg gcggtggagc
      841 acaggccgac caggctgacg gccagcagct cctcgccccg gcggtgggcc aggacggcgg
      901 cggcgagccc gagcacgccg atcacggcgg ccagcaggac ccagatgttc tgggtggcct
      961 cgggcgggga caccagccgg gccaggaagc cgcgcagggt ctggttgccg gtcgaccaca
     1021 cgtcgccgac ccgggcgacc tcgctgaact tctgcctcac ccagtacgcg tacgcgtcgg
     1081 cgggcttgag cacgaagccc agcgcgatgg tgccgacgaa gctcgcggtg gccaccccgg
     1141 ccgccttgaa ctgcctggtc agcagcaggt acgggatgaa gatcagcggc gtcagcttga
     1201 tgccggcggc gatgcccacg ccgatgccgg tccagttgga cttgcgggtg cgcagcaggt
     1261 cggcgaccac gatggccagc agcagcacgt tgatctgccc caggtacagc gtggtccgca
     1321 ccggctcgaa catcagcgcc agcgcggtgc ccagcagcac gacgccgacg gccgcccggt
     1381 cccgccggta gcccatccag cgccagcacc gcgccaccgc gaacagcagc aggagcacgg
     1441 tcacgacgct gtagacgatc tcggtgccga ccagcggcag cagcgccagc ggggcgaaga
     1501 tgatcgccgc gaacggggtg taggtgaaca tcaggctggc caccagcggg tgggcgtaca
     1561 gcgactgccc gtccagcacg gtcaggccgc cggcccggta cacctcgaga tcgatctgca
     1621 tccacatgcc gaccggccag atgaccgtgc acaccgcgaa ccacgccagc accgccacga
     1681 tcacccacgg tgtggcccgg cgcagccaga ccggcacggt cagcggccga ggttgatgac
     1741 actgtgcgcc ctcggtcggg gtcggcagga aagagtcggc gacccgcgtc cagaatccgc
     1801 gggtggtctt gacgtccgac actgcgctcc ttcgtgaaat gcccacgatc gggcgcttga
     1861 ccagccagtt cggggattgc ctttcacggt aacacgggcg gccggcgcga ccgccggtgc
     1921 cccggatcgg cggtgactac caacagtcac cgcatcggtt ggcgtcatcc gataagtcgt
     1981 gtggcgcggc cgggtccggt gagccaagct gatcaccgtg ttggactcgg cgacaccacg
     2041 acggatcctg attctgtccg ccgacatggg cgagggccac aacgccaccg gccgtgcgct
     2101 ccgcgcggcc gcgggccggc tgtggcccga tgcctcgacg cactggctgg acacgctcga
     2161 cgtgatgggc cgcggcgtcg ggccggcgtt ccgccgcatc tacgtcacca acgtggagcg
     2221 cactccctgg ctgtacgagt tcttctacaa ctcggtgtgg cgctaccgct ggttcgccac
     2281 ggcctccaag cggttcgtgg gcgagtgggc cggccggcgg ctggccgcgc ggatcgacca
     2341 gatccagccc gacctgatcc tgtccacgta cccgctgggc acggccggcc tggactggct
     2401 gcgccggcac cgcgggctgg aggccccgat cggcgcgtgg gtgtcggact tcgcgccgca
     2461 cccgttctgg gtgtaccagg gcatcgacct caatctggtg atgcacgagg tcgccgtgcc
     2521 ggtcgcggcc cgcagcgcgc ccggtgccac ggtggcgatc tccgcgccga ccgccgacga
     2581 ggtcttccgc cccggtgacc gtgccgccgc gcgggccgag ctggagctgc cccaggacac
     2641 gttcgtgtcg ctggtggcct gcgggtcgct gggcttcggc cggtccgagg acacggtgca
     2701 ggagctgctg gtcggcaatc cggacggcct cgtggtggtc gtttgcgggc gcaacgagcg
     2761 gctgcgggcc cggatccgcg ccgcgatcgg cgacgacccc cgcgtgcgga ttctcggctg
     2821 gaccgaccag atgtcgacgc tcatggtggc cgcggacgtg gtggtcacca atgccggcgg
     2881 ggcgacgtcg ctggaagctc tcgcagtcgg tcggccggtg ctcatgcatc ggccgatcgc
     2941 cgctcacggg cgggccaacg cccagctcat ggccgacgcc ggcatcgccg tggtgtgccg
     3001 gcgggacggc gagctggctg aggccatgcg ggacctgccg cggctggccc agatggagca
     3061 gttggcgttg aagcaggccg acgagcggct ggtggaggag ggcttgctgg ccctgaactc
     3121 cacccggccc gagcggctcg ggcgggtgct gtcggccgag gactcgctgt tcgtgcacat
     3181 cgcgtcgcct cgggtgccgc agcacgtcgg caccatcatg gagatgtccg gcgaggtcag
     3241 cgtggatgac gtggcgggca tgctggacgc catgcacggc gtgcgcggtc acgtcgaccc
     3301 cggttcgtgg ctgcggcggc cgcgatggac gcaggacgag gccgtggagg ccaaggctct
     3361 cgtgtccgaa gtggacggtg tttcgctgcg ggaggccgtg gattccttct acgccaggcc
     3421 gttgccggcc ggagcgaccg ccgaggcgct gatcgtgcac ggctcgtcgc cggcggtgct
     3481 gatcaagctg caccacgccc tcggcgacgg cgtcgccgtg ctgcgcgggc tgctgggcgg
     3541 aacctcgggc aagggcaggg cgtgggcgag tcccgtcggg catcaggtca gccacaagtt
     3601 gccccggttg cggctcaagg gtctgctggc gctggcccgg gccggtgcgg tgccgcgcgg
     3661 gccgaagttc ggggcgtcgc gccggctcgg tctggtcaag ctgcccgggg ccgaggtgcg
     3721 ggccactgcc cggggcctgg gcgtcacgcc gaccgagctg ctgttggcca tgttcgccct
     3781 ggcctaccaa ggggatcggc tccgggtgat ggtgccgtgg tcgctgcgtg gcaccgacac
     3841 cctgcgcgcg gccggcaact ggaccggggc tctgtccgtc gacctgcccg tacaggagac
     3901 ggatccgttg cggtgcctgg aactcgtgcg tgacgcgctg cgggccggtg tcgagtccgg
     3961 cgcacccgag gcggcgaact tcgtcgtgcg gctcatcggt ctgctgccgg cgcccgcgca
     4021 ccggctgctg gcccggctgg tgtaccagtc gcggtggttc ggcgccatcg cctccgtgat
     4081 tcccggaccg cgatggcagg ttttgttggg cggtgcggag atcgaggccg cttacgcggt
     4141 gctcccgctc gccgagggcg tctccatcgc ctggggcgct ttgacctggg gaccacatgt
     4201 gaccgtctgc gtgaccgggg gcggcgccgt cgacggctcg tcgctggccg agcggatggt
     4261 cgacgcgttg cgggagttct caggcaggac accatgaacc tgatcatcgc cgtgccagct
     4321 gccgtcggag gtgctgcctt cttcggtctc accagtgccc tgcagcaccg ggcgacccag
     4381 caggtgcggc ggcgggaagc cctggagccg gggctgctcg tcgacctcgc tcaacagcgg
     4441 gtgtggctgc tttccttggt ggccaacgcc ttcggcgtga tcctccagtg ggtggccctc
     4501 accaccgggc ccctggtcct ggtacagcca ctgctcgtca ccggcttgct gttcggtgtg
     4561 ctgttctccg gttccttcga ccgggtagtg ctgctcggcg ccggtctctg cgtcgccggg
     4621 ctcgccgcct tcctcctggt cgcccagccg tccggcgaca gcacgggaat gaccctcggc
     4681 gccgtgctgc ccctggccat cggcctggcc gccatcctgg ccatttgcct tgctgtggcc
     4741 gcacatcgcc ccggcaacac ccgctccctg gccctcgccg tcgctgccgg cgtgctctac
     4801 ggcgtcagcg ccggggtggc caagctcgcc gccgagcagc tgtcccaggg catcctcgtg
     4861 ctgctcaccc actggcccat ctacgccgtc gctgtctgcg gtccgatcgg cttcctgttg
     4921 agccagaacg cattccaggc cgaacgggcg ctggcgccgg ccctcgccgt gatcaccatc
     4981 ctggaccccc tcgtcggcat cggcatcggc atcctgtggc tgggggagga tctgcgcagc
     5041 ggcgtcggcc ccgtgatcgg ccaggtcctc gccctgctcg ccctgtgcgc cggcgtcttc
     5101 gtcctcagcc gccgcgcccc gcaaaccgtg gccaaggaag cggaatgccc gcgatgacca
     5161 gcacccgccg gctcaccgtc agcaaggaga tcccatgcct gccgtgaccg gcatgcgtgc
     5221 cctggtcacc ggcgcgtcgt ccggcatcgg cgccgccacc gccgacgtgc tcgccgccaa
     5281 gggcgccacc gtgctgcgca ccagccgcac catcaccggc ccctcctcct tcgcctgcga
     5341 cctcgccacc ggcgtcgacc ccctggtcgc ctgggccggc gacgtcgact tgctcgtcct
     5401 caacgccggt ctcggccacg ccggcccctt cgccgacatg cctccggcgc ggatccccga
     5461 gctcttcacc gtcaacgtcg tctcccagct ccaactggcc cgcgccctcc tgcccggcat
     5521 gctcgcccgc cggcgcggcc acatcgtgct cgtctcctcc atcgccggcg ccatgggcgt
     5581 tgccgacgag gccgtttact ccgccaccaa gtccgccctc cgcgccttcg ccgacgccct
     5641 gcgcctggag gtccgcaccg tcggcgtcac cgtcatccac cccggcgtca tcgacacccc
     5701 gttcttcgac cgtcgcggca ccccctacac ccgtcgccgc ccccgtccca tcccgcccgt
     5761 cgatgtcgcc gaggccctcg tcgccgccgt cgaacacaac cggcccgaga tcttcgtccc
     5821 ctcctggctc cgcttccccg cccgcctcaa cggcgtcctc cccgccctcg tccgcaccct
     5881 ccaacgccgc ttcgggtgat tgcgttgttc ggccgcttct gatctggatc tggtccgtct
     5941 ggccctggag gtggaacggc ccgcaccgca gtcgtgagcg gtgcgttcga attccgtatt
     6001 ggcagggtgt cgcccgggtg ggcggcaccc tgcttttcgt taccggatcg accggatgag
     6061 cgtggcgtgg caccgggttc gctatcggtg acgtgcccgg cgaaatgggg ttttcggctg
     6121 ttgcgtccgt gatcggggca aacccttgcg gtgatcggcg ggatagactg gtgggaacct
     6181 tgcgcgtagg ggaggggccc gagtggtgga cacgccgttg atccggagtc tgcgtgcggc
     6241 ggtggaggcg gtgcccgggg atgtgacgtt gcggttgcac ctggctgagc agctgctggc
     6301 ggtgggggac gcggaggggg cggcggagca ggcggcgacg gcgttgcagc acgatccggc
     6361 gtcgcaggcg gcccgggcag tgttggggcg ggcgttggga gcgccggggg agcaggtgcg
     6421 acagcctcag ccggtggagg cccaacagga gtcgggcgga gagccggagg agcctgaggg
     6481 gagccagcct gacgaggccg aggccgagcc ggagaaggtg gagccggtgc cggtgttcga
     6541 ctgggccgcc gctgaggagg atctggggtt cctggacgtc gaagagggtc ggatcacgtt
     6601 gaaggacgtg ggcggcctga aggcggtgaa ggagcggctg gaggcggcgt ttctggcgcc
     6661 gatgcggaat ccggagctgc gcaagctgta cgggaagagc atgcgcggcg ggctgatgtt
     6721 gtacgggccg ccggggtgtg ggaagacgtt cgtggcgcgg gcggtggcgg gggagctggg
     6781 ggcgaagttc atctcggtca cgttgtcgga tgtgctgaac atgtacatcg ggcagtcgga
     6841 gcggaatctg cacgagatgt tcgagacggc ccggaggaac gcgccctgtg tgctgttcct
     6901 ggacgagatc gacgcgctgg ggcagaagag gagccagctg cgctcctcgg cgatgcgggg
     6961 cacggtgaac cagctgctgg tggagctgga cgacgtgcgg gacagcaacg agggcgtctt
     7021 cgtgctggcg gcgacgaacc acccgtggga tgtggactcg gcgttgaagc ggccggggcg
     7081 gttcgaccgg acgttgctgg tgttgccgcc ggatctggag gcgaggcagg cgatcctggc
     7141 ctaccacctg aaggaccggc ccacggaggg gatcgacctc gggaagctgg cgaagcggac
     7201 ggacgggtac tcgggggcgg atctggcgca cgcgtgtgag gcggcggcgg agaaggcgtt
     7261 gctggactcg gtgcgcaggg gacagacccg catgatcggc atggcggacc tggaagaggc
     7321 gctgaaggag atcaagccct cgacggtgcc gtggttctcg gcggcccgga acgtggcgat
     7381 gttcgcgaac gagggcggga cgtacgacga actgctcgcc tacctgaaga agcaccggct
     7441 ggcctgaatg gacagcatcg gccgggcccg cacgctgatc gacctgggcc gacacgagca
     7501 ggccagggtg gagctgggca aggtcctggc cgacgacccg gcctcgacgg aggcgtggtg
     7561 cctgctggcc cagtgcgagc agaaggcggg cgacgtcaac gcgatgcggt acgcggcggg
     7621 ccaggcgctg gcgtccaatc cggacagtga gtgggcgcac cggctgcagt cgctggcgct
     7681 gcacaagctc ggccgccatg aggaagcgat cgaggcggcc agggaagcgg tgcggctggc
     7741 cccgcaccag tggcagcagt acgtggtcct ggtgacggcg atgatcccga ggctggacct
     7801 gtaccgggcc gaggccacgt gggcggcgga ccggtcggtg gaactggcgc cgcagcatgc
     7861 ggaaacgcac ctcacgcgcg gggttctggc cggggcgcaa gggaatctgg tggatgcgga
     7921 gcggaactac cgggaggctc tacggctcga cccggagaac gcggcggccc gcaacaacct
     7981 ggcgacgatc cagttgcgcg gcaatgacct ggagggggcg accgcgggct tcgcggcggc
     8041 gctggccgag aacccgcggc tccaggtggc tcgggacaac atcgacctgg tctgccggcg
     8101 gatcctgcgc ggcgcgcggc tggccgccca ggccgtcttc gtcggggccg ccttcatcac
     8161 gctcagctcg gaaggtggcc ccgcgctccc cgcggtggtg gcgggactgc tggtggtgtt
     8221 ctgggccgtg atggtggcca ggctggtccg ccgcttggcc aagccggtcc gcgcccacct
     8281 gcgcagccag ctccgtcacg agcgccggca catcccgatc atgctggtca ccgcggtcta
     8341 catcgccgcc gcgctggcgg ccgcctggat gccggtccag ctggtgacca gcggcatcct
     8401 ggcgaccgtg gtgtacatgg tcagcgaacg gctccggcgt ccgaaggccg cctgaacgag
     8461 gtcagcggcc gacggcggcc cgcagggact gcttgagcga gccgagcgtg gcgagcacgg
     8521 cggtgggttc gtagccgcag tgcgccatgc agttggcgca gcgcggatcc ttgccgcggc
     8581 cgtaggcgtc ccagtcggtt tcgtcgatga gctcccggta cgtcttggcg tagccgtcgg
     8641 acatcaggta gcacggcttc tgccagccca gcagcgaata ggacgggatg ccccacgcgg
     8701 tgcaggagaa atcgaccttg ccctcgagga agtccaggaa cagcggggag tggttgaggc
     8761 gccagcgcct gcgccggccg tcggcgaagg ccttgcggaa cagctccctg gtctcctgca
     8821 cgccgaggaa gtgctcctgg tcgggggcct tctcgtaggc gtacgcgggg gagatcatca
     8881 tctcgctgac ctggaggtcg tcgttgaggt agtcgagcac ctcgatgacg gtctgcggcg
     8941 tgtcggtgtt gaagaacgtg gtgttggtgg tgacccggaa cccgcgcttc ttgagctcct
     9001 tgaccgccgc cacggcctcc tcgaacacac cctgtttggc cacggactcg tcgtgccgct
     9061 cctggagccc gtcgatgtgc acggcgaagg cgaagtagcg ggacggcttg aagtcgaact
     9121 tgtcgatcca tttgcgcagc agcacggcgt tggtgcacag gaacacgtac ttcttgcgcc
     9181 ggaccagctc gttgacgatc tcgtcgatct gcgggtgcat gaggggctcg ccgccggcga
     9241 tggagaccat cggggcgccg cactcctcga tggcgtcgat ggcccgctgc accggcatgc
     9301 gctggcgcag cagatcgtgc ggctgctgga tcttgccgca gcccgcgcac ttgaggttgc
     9361 aggcgaacag gggttccagc tccacgatga gcgggaactt ctcgcgccgg cgcagcttct
     9421 gcccgagcag gtagccggcg attcgcaggc tctggtgcaa cggcatgttc actggtggac
     9481 ctctttcgcg ttcgactccg cccagtgccg cagcaccggg ccgatagcgg cgaggcggcg
     9541 cagcgccgcg atgccgccgc cgagggtcgc cggacccagc aggggccggg acggcgtgtc
     9601 gacgatcgcc cgcaccacgg cgtgcggtcg gtcgccggcg agggcgagca ggccggcgga
     9661 ctccatgtcc acggccagcg cgccggtacg ggcagccagc tccgcgcgtt cggcggagcc
     9721 gacgaggtgg tcgctgaacg cgacagcacc gtggtgcacg acaaagccgt tgccacgcaa
     9781 cgacaacgcc agggaacggt cgtcgacgac gaggtcgccg gggttcagcc cgtcgaccag
     9841 cgccccggcc agaccggcca cgaccagggc ggcgccggcc ggcagcgcga gccgggacgg
     9901 gtggcgaaca cccatcccga ccgcggtgac cggcacgccg cgcagcccgc gccgcagcgc
     9961 gaaccgctcg atccgcagcg cggtggcgac gaccagggga tcagccatcg agataccgac
    10021 caagggccgt cagcgggaaa accaggcggt acaggtggta gttgatgtag aagtcgccgg
    10081 ggaagccggt gccggtgaac tgcggctcgt cccacgtgcc gtcttcccgt tgcgtggcga
    10141 caagccagcg cacgccccgg tcggtgacgg gcccgcgctc gccggcggcc aacagtgcga
    10201 gcagcgccca cgcggtctgc gacgcggtgg agtcgccccg cccgacccac gacttgtccc
    10261 gataggaccg aaggtcttca ccccagccgc cgtcggcgtt ctggtgctgt tccaaccacg
    10321 tcacggagcg ctggatcgcc gggtgcgcgg tcggcaggcc ggcggcgatc agcgccggca
    10381 ccacggcgcc ggtgccgtag atgtggttcg caccccaccg accgaaccat gagccgtcgg
    10441 cctcctggtt gtccagcagc catttgacgc cccgctgggc cggctgcatg ccggacagtc
    10501 cttcgtgggc cagcatctcc accacgtgcg cggtgacgtc ggccgacggc gggtcgatca
    10561 ccgcgccgaa gtcgcagaac ggcagcttct cggccatccg ccgggtgttg tcggcgtcga
    10621 acgcgcccca gccgccgtcc cgggactgca tgccgacggt ccactccacg gcccgctgca
    10681 ccgcgggctc gtcgggggcc attcgccgca gtgccaacac gatctcggcg gtgtcgtcca
    10741 cgtcggggta gttgtcgttc tcgaactcga acgcccaccc gcccggcggc agcgacggcc
    10801 ggcgcacggc ccagtcgccg cggacggtga cttcctcgtc cagcagccag ttcccggcgc
    10861 ctttcagcgt cggatcgtcc ggcggcacac cggcgtccag cagcgcggtg acggccaacg
    10921 ccgtgtccca caccggggac tggcacgcct ccagccggcg ggacccgttc tccttgatgg
    10981 tgaacgactc caggccgtcg aaggccttgc gcagaaccgg atggtcgagc ggatagcccc
    11041 gtaggtgcag cgccagaatg gaatacaccc acggcggctg gatcccgccc cacccgccgt
    11101 cggcctcctg ccgggccagg atccacttga tggccttgcg aatgcagtag gcccgcagtg
    11161 gtttcaccgg cagcttggcg tgcaggtgca gcaccttgtc cagccgctgg aagaatccgg
    11221 cccagctcag cgccggctcg aacggctcgg ccggcctgcc ggtcctcagc tcggcgaccg
    11281 agatccccag cggccgcacc ggccgcatcg agccgacgat ggtcaacggc accacggtct
    11341 gccgcgccca gcagccccag tcgtagatgt tgagcgggaa ccacttgggc agcaggatca
    11401 tctccggcgg cagcaccggc agccggtccc aggaccactc gccgaacagg gccagccaga
    11461 tccgggtgaa cacccgggtc ttctcgatgc cgccgttgtc cagcacgaac tgccgggcct
    11521 tgaccatgtg gtcggcgtcg gcgggatcgc cggccagctt cagcgcggtg tacgcctcga
    11581 cggtggtgga cagctcgccc ggcccgccgt agaaggtggc ccaggtgccg tcggcgcgct
    11641 gctgggaccg gatccagttg gcggtctcgg cggtgccgac cggctcgcgg atgccgagga
    11701 actggcgcat cagcatgtcc tcggcgtcca ttgtgacgtt ggtttccagc tcgcccttcc
    11761 accacccgtc gccgtcctgc aacgacacca ggtggtcgat ggctttctgc ttggccaggg
    11821 ccacatcgct caccgatcgc gctccgccac gaagtgcgtg atctgccaca gagcctcccg
    11881 aatttcttca ggcgcgccga cggcgtccag acactcgccg gcggcggcca cctgccggtc
    11941 ggcctcggcc tcggcccagg ccaggccgcc ggcctgctcg atgagccggg cgaactcggg
    12001 cagttcctcg tcggcgggcg tgccctcgac gaggtaccgc gccgcgagct cgtcgccggc
    12061 cgcggtgccg gacgtcagcg cggcgacgac cggcagggac ttcttgcgca ccttgagatc
    12121 cgcgagcacc gccttgccgg tcacctccgg cgcgccgcag atcccgagca ggtcgtccac
    12181 cagctggaag gccagcccga ggtgcatgcc gaagcgggcc agcagctcca cccgctcggc
    12241 cggggccccg gccaggatgg cgccgatgga ggcggcgcag cgcatcagtg cgctggtctt
    12301 gccgttggcc atgtcgacgc actcgtgcag cgtcacgtcg cgacggcgct cgaactccag
    12361 gtccttgctc tgcccggcga tcaggtcctg cacggccagg gtgacgctgt cggtcgcggc
    12421 cggcgaggca gccggctgaa gcacctcgac ggccagcgtg agcagcgcgt cgccggccag
    12481 gatcgcagcc ggcacaccga aaagcttcca cgccgtcggc cggtgccggc gttcgacgtc
    12541 gccgtccatc acatcgtcgt gcagcaacga gaagtcgtgc acgaactgca ccgcgaccgc
    12601 gccgggcacg ccctgctcgg cggtgccgcc ggcggcctgt gcggacagca gcgccagtgc
    12661 gggccgcagg gccttgccgc cgcccttggc ggtcgggttg ccggcctggt cgatccagcc
    12721 gaggtggtag ctcaccacgt tgcggatgga cgggttgagc gtgtcgaccg cgcgccgcat
    12781 cgccggctgg accagatcgg cggcggtggt gaccggccgg ggcagcgtcg cggtcaccgg
    12841 gccacctcgc tcacggtggc gggaagctgc tccgacaaca accttgccgc gttctgtccg
    12901 ctgcgcacgg cgccctccat tgtgtctggc caccccgtcg cggtccacgc gcccgccagc
    12961 accagtccgg gcgtgccggt ccgttgcgcc gcgcggcgtc ggccactgcc cggctgctgc
    13021 cggaaggtgg ccgtccgttc cttggtgacg aaaaaatcgg tgggaacctg cccggcggct
    13081 ccgggcagca cccgggcgat ctccggcagg aacagctccc gcaaccgcgc cacgggcagg
    13141 tcgatccact cgctcgcggc cgacaccgac acggccaggt actggccctg cgtcagcccc
    13201 gacaccgagg tccggtcgaa cgcccactgc accggtgatc cgaccaccgc gaggaacggg
    13261 aggtcggtca cgcgccgcgg gaagatcacg tgcacgttga agatggggga gtggccgagg
    13321 tcgtcggtga cggtgtcggg cagcagcctg gcggcggcgt cggccgacgt ggccaccacc
    13381 accgcgtccg cggccagggt gtcctcgccg gtgacgacct cgaaaccgtt gtcggcccgg
    13441 cgaatctcct tgaccgcggc gtgcagccga acctgggctc cgtgggcccg caggtaagcc
    13501 agggccggct cgccgtgcag ttcggacagc ggcacggccg gcacgccgat gtcgcagttc
    13561 tcgctgcggt cgagcagacc ggtgcggaac accttggccg ccaaggccaa cgaggcttcg
    13621 tcggcgtcgc agttcagcgc ggccacggtg atcaggttcc acagcgcgga aatggtgttg
    13681 tcgttctgcc cgtgcgcccg cagccagtcg cccaggctct gctcgtccag ccggggatca
    13741 tccgggtcca gccgccgcat cgccggaacg gcccaggccg cgcgcacccg gtccacggga
    13801 gacagcagct tgtacgtggc cagcgagccg agcaggtgca gcggcgccgg caaagcggtg
    13861 cgggacaagg aacccagccg gccgtcggct ccctgcaccg ggatggtcat ccgcggctgc
    13921 atctcgatgt ggtgagcaac gcccagtctg cgcaggaagt ccaggtaagc ggtgtagcag
    13981 cgcagcagca cgtgctgtcc gttgtcgacg acgagatcgc cgcggctgaa ggagaacgtg
    14041 acgccgccga gccgggcccg ggcctccacc agggtgacgg ccaggccgcg gtcggccagt
    14101 tcgcaggcgg cggtgaggcc ggccaagccg ccgcccacga caaccacccg cgccgtcacg
    14161 gccgcgaccc ggccagcgaa cgggccgcca ccaggacttt ctcccagtcg ggcaaggatg
    14221 ttcgggaact gcgcaccagc cacggccggg tcatcatgcg ggccagcagc cgatggtaga
    14281 tgccggccat ggccgcgcag caggcccggc tgcggccgtc caggcggggc agcagccgca
    14341 ggccgacggt gtaccactcc tcggcccgcg cgccctggta ctccagcagc gcggtcagcg
    14401 cgtcctcgtt gtccaccagg ttgccgtccg cgtcgaggtc cagcgtgcag ccgaaccggc
    14461 gcagatcctc ggccggcagg tagatccggc ctttgcggcg gtcctccagc acgtcccgca
    14521 ggatgttggt cagctgcagg gcgacgccga gcgcgtcggc cagttgggag tcgcgggcct
    14581 ggtcgggact gccgaacacg gccagcgaca accgtccgat cgagccggcc acgcagcggc
    14641 agtagtgccg aaggtcctcg aagttctcgt acgccgtgcc gagcacgtcg gcctggcagc
    14701 cgtcgatcag ctcgtcgaag gcgcccagcg gcaggccgaa ccgcagcgtc gcgtcgttca
    14761 gcgcgacggc gaccgggtcg tcccggagat ccgcgagatt gtgcaacctt tcacgaactt
    14821 cgttcagccc agccaggcgc tgctccgcgg gcgcgtcgcc gtcgccgatg tcgtcgacga
    14881 tgcgggcgaa ggcgtagacc gcggacagcg cgcggcgctt gagcggcggc aacagcctga
    14941 tgccataaga gaaattcttg gcctgctcgc cggtgacgtg ctcacagtgg tcgtaggcgg
    15001 cctcgatcgt cacggacagc gcggtcaccg gccaccgccg agcgaccgtg cgagttcggc
    15061 gactgtgcgg gatttacgtg gccgtggcgt ggttgtcagc acatcgaaac gcgcgttgac
    15121 tatcgccgcg gcggtggccc gcccgccggc aacgtagccg gcgacggcca gccgggccag
    15181 tccgcgcagc gtgccgacga tggcggcgcc ctcgtcgagc agccgcagcg tgcgctgggt
    15241 ctcgaacgcg atcagcgccc gcacctcgcg attcgccttg ctggcagcca gatcctgttc
    15301 ccggacgccg aaccgctcca ggtcctcggc cggcaggtag atccggccgt ttcgccggtc
    15361 ctcggccaca tcctggaggt gctccagcac ctgcagcgcc gagcacacct ggtccgagag
    15421 cgccgcgcgt tccggtgaca tcgcgtcgaa cacgtgcaac accaggtgtc cgaccggatt
    15481 ggcggacagt tcgcagtagc cgagcaggtc gtcgaaggtg cggtaccgct tgacttgttg
    15541 gtcgcggcgg ttggcctgca ccaaacggtc gaacggggtg cgcgggatgc cgcactcgtg
    15601 cacggtcacg gtcagttcgg cccatagtcg gtcggtcgcg acgtagccgg cgtagatccg
    15661 gtcgatatcg cgttcgacct tgtccagcag ggcattccgg tcgccggggg cctcgtcgcc
    15721 gatgtcgtcg acgaggcggg cgaaggcgta gacggacagc agccgacgcc ggatccgggg
    15781 cggcagcagc aggctggcga cggtgaagtt ctcgctgccg gcccgccggt gcagcgccgc
    15841 gacatcgggg ctggcagggg tgggcggctg gggcagggat gtagtccaac tcggccgggc
    15901 aggcgtgtcg accacggggt cctccggtgg tgctcgcgga gtagcagtgt cgagcgccgg
    15961 tcgtggtgcg ccgatcccgg tgccccggtg ggcccgccga cggccggtgt ccccatacgg
    16021 tgatccactg tgggaatctt cgcaacctga atcaacacca tgagaccttt tcgggccatc
    16081 gccgaacgcg ccgtcgtcgc gtgccggtcc catggttgag atccaaccga ccagtcggta
    16141 tgttgttgcg ccagcaatag ccgtatccga tcgagcgagg atgtggttgg tgtggcggcc
    16201 ttcagcgtgg atggcacctg tgacccggca ttcgccccgg tacgagacgt tctggcagct
    16261 caactggccg acggccggca gctcggcgcg gccgtcgcgg tccgcgtcgg tgatcgggaa
    16321 gtcgtggacc tgtggggcgg gcacgccgac cccgaccgcg ccaagccgtg gctggccgac
    16381 accgtcgtca acatctggtc taccaccaaa ggtgtggtcg cgctggcgtt ccacatgctg
    16441 gtcgaccgcg ggctgctcga tccggacgcg cccgttcgga agtactggcc ggagttcgcg
    16501 aacgacagcg tgttggtgcg acacctgctc tcgcaccgtg ccggcctggc cgcgttccgt
    16561 gagccgacca ccgccgagga gctggccgac tggaacttga tgatcactcg gctggcggac
    16621 acccggccgt ggtgggagcc cgggacggcg tccggctacc acgcgctcac ctacggtttc
    16681 cttgtcggtg aactgatcca tcgggtgacc gggtcgtccg tgcgggactt cgtacaccgc
    16741 gaagtggccg aacggacagc ggccgatttc cggatcggac tgtctccggc ggacaacggc
    16801 cgcgccgcca ccctggtgca gccgccgccc gcggaccccg ccgccttcca ggcgatgttc
    16861 gcccagctca atccggtggc gctggccgtg ctgaccaatc cggtggtggg acccgaccag
    16921 ggcaactccg cctactggcg ggccgcgcag atccccgccg ccaacgggca tgccacggcc
    16981 cgcgcggtcg cgacgctcta cggcgcgttc gcctccggcg gtgtcgccgg tggacaacgg
    17041 ctgctcgggg ccgcgcaggt ggaacgggcc cgtgaggggc agggctccgg tgtcgacctg
    17101 gtcatcggcg acgccggcct gggcggccgg gaaaccgaac tgggcctggg cctttggctg
    17161 tccggagcgg acggccacta cggacccaat ccccgcgcgg tcggccacga cggcttcggc
    17221 ggctcgttcg ggctggccga tcccgaggcc ggcctggcca tcgggcacgt gatgaacctg
    17281 atgggcaacg tcatcgccga cgacccgcgc aagatggagc tcatcgcggc cgtctattcc
    17341 tgcctgtgaa aatcactgga ccccgctgac atgctcacgg agtgttcgct gatctgttgc
    17401 gccaccgcag tttccgctgg ttgacgctcg gacgggggat cagcttcgtc ggcaacgcca
    17461 tggcgccgat cgcgctggcc ttcgccgtgc tggacctgac cgggtcggtc gccgacctcg
    17521 gtctggtggt ggccgcccgc tccgtggcca acgtggcgtt gctgctggcc ggcggcgtgc
    17581 tggccgaccg gctgccgcgc gcggtggtgt tgcagggatc cagtctgggc gcgggaatat
    17641 cccaggcgct ggtggcgtca ctggtgctga cgggaacggc ttcggtgccg ctgctggccg
    17701 tgctgggcgt ggtcaacggc gcgctgtcgg ccgccttcct gccggcgtcc agtgcgctga
    17761 caccgcagac ggtgccggcg gatctgttgc gcacggccaa cgccgcgtcc cggatgacgc
    17821 gaagcgtggc gatgatcgcc ggcggttcgg tagccggcgt gctggtggcc gcggtcggac
    17881 cggggtgggg catcgccgcc gacgcgctgg gtttcctgct ggcggcggtg tgtttcatgc
    17941 gggtgcgggt cgccgagccg gcccgtgagc gctcgcacgt gctggccgat cttcgggacg
    18001 gctggaccga gttcaccggc cggacctggc tgtgggtcgt ggtggcgcag ttcctttttg
    18061 tcaacgcgat caacgcgggc gggctccagg tgctcggtcc ggccatcgcc gaccagacgt
    18121 tcggccggac cgcctggggc ctggccctgg ccgccgagac ggttggggcg ttggtcggcg
    18181 ggttcgtcgc catgcgctgg cagccccggc acgcgctggc cgtcggcgtc gcgctggtcg
    18241 tcctggacgc cgggccgctg gtcgggctgg cggtcgcgcc gacggtggtg gtgatggtgg
    18301 tgacgttggc gttgaccggc ttcggcatgg aacaggccgg catcgcgtgg gacgtctcgt
    18361 tgccgcacca cattcccgcc gaccggctgg cccgggtcta ctcctacgac gccgtcggct
    18421 ccttcatcgc catcccgctg gggcaggtgg tcgccggccc ggtcgccgcg gccatcggca
    18481 cccagtcggc cctgctggcc ggagccggga tcaccgtgct ggccaccgtc gccgccctcg
    18541 gcagccgttc agtgcgaacg ctctcttcag ttccgcgagt cccgctctcg ggcaactgag
    18601 ttaccggttt ggggcggggt cttttcgggc gtgacagttg ccgatagcac gagtcccgct
    18661 ctcgtgtcac agcgagtccc gtcctcggga cagtcgcagc gtggttgcgt cgactggtgg
    18721 gtcccgagga cgggactcgc ttgcccgaga acgggactcg cggattagca ggtgatctgg
    18781 gcgttggccc agtcggcgtg gtcgttggtg ttgccgtcgc cgccgtcggt gacgatcagg
    18841 cggagcaggc cggcgccggt gacgtcggcg tgcagggact gggcggggtc gccgcgcttg
    18901 atcaggccgg tgtcggcgac cttgttgcca tcggcccaga tctcgaaggt gacggagccg
    18961 gcgccggtct tctcgtcgtc gaggccgacc gtggcggtga cggcggagca gtggccggcc
    19021 gggtagtagg tgatggtgct gggggcgttg acgccgaggc ccttggcgta ggtgacgccg
    19081 ccgagcgtga tcggatggcc gtcgccggcc ttggactcgc cgttgctggt gttgcgttcg
    19141 accggcccgt agccgttgtc ggccgacagc cacggatcgt cgccgaggcc ggtggtgccg
    19201 gcggtcagcg gggcggcgac cgagacggtc agatcatagt ccgaagtgga ctttccaggg
    19261 tagtaggttg tgctgacatg caagggatag ctgcccggcg gcgtgtcggc gggggtgctg
    19321 acagaccact tggtcgacac gtcgcggccg gccggcagca ccggatggaa cgtcggtgac
    19381 gtggctttca ccgtccagcc ggcggggccg gtgagcttga cctcgccgag aagtccaggc
    19441 aggacaccgt cattggtggt cgtggtggtg agagtcgtgg tggtgccggg ctggacgagc
    19501 gccggcgcgc cggggtaggg gagcggcagg tcggcgctgg tgtgcacggc cggcgggttc
    19561 gaccaccagg cgccgccggc gtgcacgcgg aacatcgccg tgccatgcgc gggaacggtg
    19621 gcgctgatct tgccggcggt ctcggtggtc ttgtgcgacc acaggtcgtt cagctggtag
    19681 cccagcgcct tgggcaggcc gacggccgcg gcggtggtgc tgatggtcgc cggtgtgccg
    19741 ttctcgttga acagcgcgac ggcccggtcg ccgcctgcca gcggcttgct gatcacatgc
    19801 agaccgttcg cattggacag ttcagttccc tggactccca agggatcctg gtccaccgcg
    19861 atgacgtcct tgttggtcag gatggccatc gtagccggcg tggccttgcg gatgtcgctg
    19921 ccgatcagca gcggcgaagc catgatcgac cagaggctga agtggctgcg gtactccgtg
    19981 tcggtcatgc cgccgttgcc gacctccagc atgtccgggt cgttccagtg cccggggccg
    20041 gcgtactggc cgagcttgat gttggccttg aagatggaca gcatcttcgc gtacgtgtcg
    20101 ttgatgtcgc cggtggtgcg ccacgagttg ccgacgctgg tggcccagtt ccacggctgg
    20161 ttctggcccc actcgcacag gctgtacagg atcggccgcc cggtggcggc cagcgcgtcc
    20221 cgcatcgcgg tgtagcgctg cacggcgtcg acgccctggt tgttgcagtt gtcgtacttg
    20281 aggtagtcca cgccccacga cgcccacagc gccgcgtcct gcttctcgtg gcccaggccg
    20341 ccggggaagc ccgcggtgtt gcaggttttg gtgccagcac tggaatacag gccgaacttc
    20401 aggcccttgg cgtgcacgta gtcggcgacg gccttgatgc cgtcgggaaa gcgcaccggg
    20461 tcgggcacca ggttgccgcc ggcgtcccgg gccggcagcg cccagcagtc gtccaggttg
    20521 acgtactggt agccggcggc tttcaggccg gaggagacga acaggtcggc gatgcccttg
    20581 accatcgtct cgttgaagtc gccgctgcag tgcgtggcgt tccagttgtt gaaccccatc
    20641 tggggggtgc gcgccagacc gttgtccaac gcgacggcgg cgggggcggt gaccagggcc
    20701 aggccggcgg ccgcggtggc cgccgcgacc ccgagcgccg ccagccgtaa ccggacagac
    20761 atcggacctc ctcgttgagt gggcggcaag gcccatcaca caaggatcgt caaaccggca
    20821 caagaagacg aaagtccact ttacgtcagt gcagggtgcc gccggtgacg gccagatcat
    20881 cggaggtgtc gacgcaggtc cgggtgagga cggccagccc gtcggcgatc gcccgcagcg
    20941 gcagcgaggg cgcgtcgggg acggccatct cgctgctgta cggcacgtgc acgaagccgc
    21001 cgcgcagccc cggccgctcg gtggcgatca ggtgcatcag gccgtagaac acgtggttgc
    21061 agacgaaggt gccggccgtg tgcgacaccg cggccggcag gccggcggcc cgcagcgccg
    21121 ccaccccggc cttgaccggc aggccggtga agtaggcggc cgggccgccg tcgacgacgg
    21181 gctcgtcgac gggcgaccgg ccgctgttgt cggggatccg cgcgtcgtcc aggttgatcg
    21241 ccacccgctc cggcgtgatc gcctcccgcc cgccggccag cccgacggcg atcaccaggt
    21301 ccgggtcggc ggcctcgacc gccttgcgca gcaccgtgac cgaggcgtcg aagccgcagg
    21361 gcagcagctg cttgaccagg ttcaccccgg gcacgtccgc cagttcgacc gcgtcccacg
    21421 aggggttggc ggcgtccccg ccgaacggct cgaacccggt cagcagcact gtggtcatgg
    21481 cttcagaatc ccatcaggta catgatcgct atgttgcaca ccagcagcgg cgcggccgtg
    21541 ggcagctggg ccttgatcgg accgtagcgg tccttcatct ccagcagcac cgccggcacg
    21601 atgttgaagt tcgccgccat cggcgtgcac agcgtgccac agaagccggc cagcatgccc
    21661 accgcgaaca cgatcgccgg gttgccgtgg aactgctgga ccagcaccgg ccagccgacc
    21721 gcggcggtca tcaccgggaa ggcggcgaag gcgttgccca tgatgatcgt gaacagcgcc
    21781 atgcccaggc agtagacgat caccgccagc agcagcgagc ccttgggcag caccgacgag
    21841 acgatcgtgc cgacggccgt gccgacaccg gcgttggcga acagcaggcc cagcacggcc
    21901 agcatctggg gcagcaccac cgcccagccg atcgcctgca gcaggcgggt tccctcggtg
    21961 aggggaagtg tgagcttcag cccgccggcc gggcgcagca gcaccatgcc gatcgcggtg
    22021 gcgaccagcg cgcccacgcc gaggccggtc agtgtggcgg ttcccgtggc cagcagcggc
    22081 tttccgtgca cggtgatcga ggcgatcatc gtgccgaaga tcagggccac cagcgggatc
    22141 atcaacgccg gcacgaaaag cttgccccgc aaggtgttcg cggcggtgat ccgctcggcc
    22201 tggttggtgg tggcgatctc cgtcctgccc agcgctccga agccggccag cccggccacc
    22261 acgatcaccg ccacgcccag cggccacggc ggagccgtct tgttcacgac gaacgtcgag
    22321 tagcagaagg aaatgcccag cagtgcccag aacgccgcgc cgccgtactg cgcccggcgg
    22381 tagctgaaac ccgcgccggc caggaagaac aggccgcaca gccagtagag ccactccgcg
    22441 tcgatcatcg cgccgacacc tcctgcttga cggtcatgcg gctcagggag cggtccagcc
    22501 acagcagccg ggccccgtgg atcagatagg cgcagacggc cgtcgggatc gcccagaccg
    22561 cgatctgcag ggcgtccagc ttgaggtggt aggtgctgtc gaccaggctg gtgatcagca
    22621 ggatcgagcc cacggccagg aagatgtcct cgccgaagaa caggccgacg gtgtcggagc
    22681 tggccgagta ggccttgacc cgctccacct gccggtcggt cagctccccg tgccggcgga
    22741 tggccgcggc cagggccatc ggggcgatca gcgggcggac cgtctgggcc ggcccgcaca
    22801 tgccggtcag gcccagcgcc gcggtgccct ggcggatcag caggtaggcg gcgagcagcc
    22861 ggcccgtggt cagggcccgc agcttgccga tcagccgggc cgcctgctgt tgcaggccgt
    22921 accgttcgag caggccgatc gccggcagcg tgatcacgta gatggtgacc gagcggttgg
    22981 tggcgaagcc ggtgccgaac gagtccagga tggcgaccgg gttcaggccg ccgagcagag
    23041 ccgtgacgat accggagacg gtgacgacca gcatcggatt cagccgcagc gcgaagccga
    23101 tcaccaccag ggcgacgccg atgaggacga ccatgtgacc tccttcacgg gatggggtgc
    23161 ctggaagggt aggtcttgtt gaacaatcct acaagatggc actacggacg gtagccgagg
    23221 gtgattgagg ccggaggggt gcggggcggg gcgatcggcg gggcgggaag gcgctcggcg
    23281 gcgagagggg gcggcgtggg cgagagggga gctaggagaa atggaggcgt ggtggtggga
    23341 atggcgctca gccaggcttc gagtcgtcgc tcgggtgggt gaaacgtccg actttcggcg
    23401 ggtggcgggc cgcgtggcta gcgggtcaac tggtccgaca ctgttacacc gtgtcacctg
    23461 acccggagcc acggaaggga ttccctgcca tgcgtaagag cgtcctcggc accctgctcg
    23521 gcgccctgct cgcgaccacc gccctgacca ccccggccgc gacggccgcg cagccttcaa
    23581 cggcccctgc tgtcgcggca atcgacttct cggggacggt ggccctgaac gactgctccg
    23641 gctccctggt gaagctggcc ggcgcgccga cctcgggccc ggctctcgtg ctcaccaacg
    23701 gccactgcta cgagggcggg ttcctcgacc cgggccaggt tctggtgaac aagtcctcgt
    23761 cccggacgtt cacgctgctg agcccgaccg gcggcaacaa ggcgacgctg cgggccacca
    23821 aggtgtccta cgcgacgatg accgacacgg acatcacgct gtaccagctg aacaccacct
    23881 acgacgcgat caagtcgagc tacggcatca gcccgctgga gatcgcgacc gcgcacccga
    23941 cgcagggcac ggcgatcaag gtggtctccg gctactggaa gaagatctac agctgcaaca
    24001 tcgacggctt cgtctaccgc ctcaaggaag gcgactggac ctggaaggac tcgatccgct
    24061 acacgtccag ctgcaacacc atcggcggca cctcgggctc cccgatcgag gacgccagcg
    24121 gcaagctgat cggcatcaac aacacgggca acgaggacgg cgagcgctgc accgtcaaca
    24181 acccgtgcga ggtggaccag agcggcaaca cgaccgtcca caagggaacg aactacggcg
    24241 aggagaccta cctgctggcc ggttgcatga ccggcagcgc ggtggacctg accaaggccg
    24301 gctgcgccct ccccaagccg tagtcccgaa aagcggctac ccggcccgcg ccggcggcgc
    24361 cgtggtggcg cgcacgatga gctgggtgtc cagctcgtcc tgccgcacct cggcgtcccg
    24421 gttggccagc cggtccagca gcaggtcgac cgccagccgc ccggccggca cgaccggcat
    24481 ggccacggtg gtcagcggcg gctggcacag ggccccgaac atcaggtcgt cgaagccggt
    24541 gagcgagacg tcgtcgggca cccgcacgcc gcggtcccgc agccgcgcca gcacaccgag
    24601 ggccatgatg tcgttgtacg ccacgatggc cgtgacgttc tcggcgatgg ccaggtccgc
    24661 cgcctgcagg ccgccctcgt agcgcggcgg gaacgggccc atgtcgacca ggtcgacgtc
    24721 gtgccgctgc acggcgatgc gcagcccccg gcgacgctcc ttgttggacc acgaggtgcg
    24781 cggcccgttc aggtaggcga tccggtggtg gcccagcgcc accaggtggt cgaccacctg
    24841 ccgcaggccg gagccggagt tcatcagcgc cgccggcacg ccccgcatgc gccggttcag
    24901 cagcaccagg gtggtggact cggccagctc ccggacctgc tgctcgtcga tgccgggcga
    24961 gcacaggatc acaccgtcga cctgcttggc catggcccgc accaactgct cctcggccgc
    25021 cgggtcctcg tcgctgtcgg cgacgaacac cgcgtggctg gccatccggg cctggttctg
    25081 cacgcccttg agcaccccgg tgaagaacgg gttgttcagg tcgggcacca cgatgccgat
    25141 gttgccggtc ttgccggtga tcaggccgcg ggcggccaga ttgggctggt agcccaggtc
    25201 ggcggcgacc gccagcaccc gttccctggt cgtcgcgcga accaggtcgg gtgaggtcag
    25261 cgcgcgcgac accgtggcga ccgacacctg ggcctgccgc gccacgtcgc ggatggtcac
    25321 cgccaccgac atgcacctgc cttcctgcag caaccggaac tgtacgggat cttcgtgtca
    25381 ggtcgcgtca ggttcgggcg tgcgacccgg ctcggccagg aagtcgaagt cgcagccctg
    25441 gtcggcctgc atgatgtgcc ggctgaacat ggccccgtag ccccgggtgt agcgaggctc
    25501 gggcggcgtc caggcggccc ggcggcgggc cagttcggcg tcgtccacat gcatgtgcaa
    25561 aagccgtttc gacacgtcca gggtcaccat gtcaccgttt tggagcaatg ccagcgggcc
    25621 gcccgcgtgc gactcgggtg caacgtgcaa tacgcaagtg ccatagctgg tgccgctcat
    25681 tcgcgcgtcg gaaatccgca ccacatcgcg gatcccctcg cgcagcagct ttttcgggat
    25741 cggcagcatt ccgtgctcgg gcatgcccgg cccgccgagc gggccggcgc cgcgcagcac
    25801 gaacaccgag tccgcggtgg ccggcaggtc ctcgtcgtcg atgcggcgct ggaggtcggc
    25861 gtagccgtcg aagacgatcg ccggaccggt gtgggacaac agctccggcc gggcg
//
