LOCUS       NZ_CP073318            20870 bp    DNA     circular CON 11-FEB-2024
DEFINITION  Kutzneria sp. CA-103260 chromosome, complete genome.
ACCESSION   NZ_CP073318
VERSION     NZ_CP073318.1
KEYWORDS    RefSeq.
SOURCE      Kutzneria sp. CA-103260
  ORGANISM  Kutzneria sp. CA-103260
            Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
            Pseudonocardiaceae; Kutzneria.
REFERENCE   1  (bases 1 to 11609901)
  AUTHORS   Jorgensen,T.S., Gren,T., Kontou,E.E., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Complete Genome Sequence of the Rare Actinobacterium Kutzneria sp.
            Strain CA-103260
  JOURNAL   Microbiol Resour Announc 10 (30), e0049921 (2021)
   PUBMED   34323613
REFERENCE   2  (bases 1 to 11609901)
  AUTHORS   Joergensen,T.S., Gren,T., Gonzalez,I., Roman-Hurtado,F.,
            Oves-Costales,D., Thomsen,E., Charusanti,P., Genilloud,O. and
            Weber,T.
  TITLE     Direct Submission
  JOURNAL   Submitted (07-APR-2021) Novo Nordisk Foundation Center for
            Biosustainability, Technical University of Denmark, Kemitorvet,
            Building 220, Kongens Lyngby, Hovedstaden 2800, Denmark
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-APR-2021
            Assembly Method :: Flye v. 2.8-b1674; unicycler_polish v. 0.4.8
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 87.0x
            Sequencing Technology             :: PacBio RSII; Illumina MiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 02/11/2024 09:18:55
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 10,392
            CDSs (total)                      :: 10,326
            Genes (coding)                    :: 10,257
            CDSs (with protein)               :: 10,257
            Genes (RNA)                       :: 66
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 51
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 69
            CDSs (without protein)            :: 69
            Pseudo Genes (ambiguous residues) :: 0 of 69
            Pseudo Genes (frameshifted)       :: 9 of 69
            Pseudo Genes (incomplete)         :: 63 of 69
            Pseudo Genes (internal stop)      :: 2 of 69
            Pseudo Genes (multiple problems)  :: 5 of 69
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 09:59:18
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 141516
            Orig. end                         :: 162386
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP073318.1.
            Bacteria and source DNA available from Professor Tilmann Weber,
            Technical University of Denmark, Kemitorvet Building 220, room 327D
            2800 Kgs. Lyngby, Denmark.
            Annotated using prokka_raw 1.14.6 from
            https://github.com/tseemann/prokka.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20870
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20870
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20870
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10870](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10870
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(430..1299)
                     /locus_tag="JJ691_RS00680"
                     /old_locus_tag="JJ691_01350"
     CDS             complement(430..1299)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF015431.4"
                     /locus_tag="JJ691_RS00680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01350"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_211766832.1"
                     /transl_table=11
                     /translation="MSNRPELVALRSFLSVYRTGGVARAAEALRLSQPAVSHHLKAIEE
                     SVGRPLFRRAGRGITPTEAGHSLAAEVAEHIDALEGALDGLRSATLSGAGPVFVGAPVD
                     LLERFVVTRMSPLLAEGLTVRCRVGLSPDLVQAVLRDEIDVALLTKIEGVPTRRMYLVP
                     LLEERFLLVGPAGDEPYEPGQERRFVGYSEEMPMARRYFRECWAIRPPAPALIVNDFRS
                     VVAAVLAGAGLTVAPHYLVEEHLAAGRLAVLHRPAQPVVNSVHIGTRRGREHLPRIRAV
                     FGALSSLD"
     gene            complement(1310..1897)
                     /gene="folE"
                     /locus_tag="JJ691_RS00685"
                     /old_locus_tag="JJ691_01360"
     CDS             complement(1310..1897)
                     /EC_number="3.5.4.16"
                     /GO_function="GO:0003934 - GTP cyclohydrolase I activity
                     [Evidence IEA]"
                     /GO_process="GO:0042559 - pteridine-containing compound
                     biosynthetic process [Evidence IEA]"
                     /GO_process="GO:0046654 - tetrahydrofolate biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="folE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GTP_cyclohydroI"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020635902.1"
                     /locus_tag="JJ691_RS00685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01360"
                     /product="GTP cyclohydrolase I FolE"
                     /protein_id="WP_211766833.1"
                     /sec_met_domain="GTP_cyclohydroI (E-value: 5.6e-64,
                     bitscore: 214.1, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHALRVVPEHTAGVDLDAAERAAGDLLRALGVDTDNESLRATPGR
                     MVRAYAELFSPRPFDLTTFPNDEGYDELVLARSIPVRSVCEHHLLPFVGVAHVGYLPDA
                     RILGLSKLARVVEHFASRPQVQERLTKQVADWLSAQLQPKGVGVVIEAEHTCMTLRGVR
                     ASGSSTVTSTMLGTLRSDARSRQEFFALAGVK"
     misc_feature    complement(1886..1888)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            2062..2682
                     /locus_tag="JJ691_RS00690"
                     /old_locus_tag="JJ691_01370"
     CDS             2062..2682
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007035274.1"
                     /locus_tag="JJ691_RS00690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01370"
                     /product="transcriptional regulator"
                     /protein_id="WP_249228171.1"
                     /transl_table=11
                     /translation="MFDFIRAARHPVTRDEAASAVGISRKLAAFHLDKLVDAGLLRAHY
                     EGAGRVGRAPKVYEPSDVDVRVSIPARQYDLLADILIDAVLSDDPRGAAEPIAAERGRE
                     IGVAEREGERPGRLGTERALTMTCRLLARHGFEPLRDTPTTVRLRDCPFHPLAGKARDL
                     VCGINRAFLAGMIDGLEARTVEAVLAPGGAGACCVELRPRQED"
     gene            2789..3997
                     /locus_tag="JJ691_RS00695"
                     /old_locus_tag="JJ691_01380"
     CDS             2789..3997
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1102: glycosyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020639100.1"
                     /locus_tag="JJ691_RS00695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01380"
                     /product="glycosyltransferase"
                     /protein_id="WP_211766835.1"
                     /sec_met_domain="MGT (E-value: 5.4e-36, bitscore: 123.9,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLLSTIGSRGDVQPVAALALRLREIGHEARLCAPPDFREWIEG
                     LGIDFVPLGPEVRPATKPDSEVRRLGATPEGRKQLMEGTVATQFETLLPAADGCDVVLG
                     WSALQLAAPSVAEKLGIRHVYAVFCPNQLPSGQHAPAPVPAWEQPTGVDNRTLWELESQ
                     RWNEQWRPAVNSNREKIGLPPVEDVLSHMNSPRPWLAADPAIGPWPEPSDLDVVQTGAW
                     LMKDTRPLPDELARFLDAGEPPVFFGFGSTGTAGLEVAQTMLESARALGRRAVISSGWS
                     DLELAAGAEDAIVIGEANFQGLFPRVAAAVHHGGSGTTTVTSISGTPHVIVPHRYDQFY
                     WAQRVEELGIGAEHRGTEPTVASLTAALDRVLRPEVAANAKAVAATMASDGVEIAADLL
                     VNG"
     gene            complement(4004..5524)
                     /locus_tag="JJ691_RS00700"
                     /old_locus_tag="JJ691_01390"
     CDS             complement(4004..5524)
                     /NRPS_PKS="Domain: AMP-binding (8-403). E-value: 8.9e-95.
                     Score: 309.6. Matches aSDomain:
                     nrpspksdomains_JJ691_RS00700_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020672098.1"
                     /locus_tag="JJ691_RS00700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01390"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_211766836.1"
                     /sec_met_domain="AMP-binding (E-value: 8.6e-103, bitscore:
                     343.3, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQLTQSVHHAVQQTPDLTATIFGDRVRTWAESVDRVARLAAALTD
                     LGVRQGDRIGLLALNSDIYHEFLLAVPWADAVLMPINTRWSANEIAFSLRDSDTRVLYV
                     DDTFAPMAPQLRELAPCLENVIEGAAAVDRLIADHEPAPDARRGGDSLAGIFYTGGTTA
                     QPKGVMLSHNNMMVSALGAVAATNTVPGGRYLHVAPMFHLAALSGWLLHNVVGGTHVLL
                     SPFTPVGMADAIERHRVTDTLVVPTMLQLLVDSPATAEHDLSSLRRLAYGASPISDALL
                     DRSTKRLPDTEFTQAYGMTELAPIATLLGPDAHQVPRLRRSAGRAAPHVEVLIVNEHDV
                     EVPRGDIGEVVARGDNVMLGYWNRPEETSQALRGGWLHTGDAGYMDEDGFVFLVDRLRD
                     MIVSGGENVYSAEVENALAKHPAVAACAVIGVPDGEWGERVHAVVVAVDGVRPTVDELR
                     DHVKEHIAGYKAPRSIEFIEVLPLSGAGKVLKRELRSRHWAGRDRSVS"
     aSDomain        complement(4316..5500)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JJ691_RS00700_AMP-binding.1"
                     /evalue="8.90E-95"
                     /label="JJ691_RS00700_AMP-binding.1"
                     /locus_tag="JJ691_RS00700"
                     /protein_end="403"
                     /protein_start="8"
                     /score="309.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="HAVQQTPDLTATIFGDRVRTWAESVDRVARLAAALTDLGVRQGDR
                     IGLLALNSDIYHEFLLAVPWADAVLMPINTRWSANEIAFSLRDSDTRVLYVDDTFAPMA
                     PQLRELAPCLENVIEGAAAVDRLIADHEPAPDARRGGDSLAGIFYTGGTTAQPKGVMLS
                     HNNMMVSALGAVAATNTVPGGRYLHVAPMFHLAALSGWLLHNVVGGTHVLLSPFTPVGM
                     ADAIERHRVTDTLVVPTMLQLLVDSPATAEHDLSSLRRLAYGASPISDALLDRSTKRLP
                     DTEFTQAYGMTELAPIATLLGPDAHQVPRLRRSAGRAAPHVEVLIVNEHDVEVPRGDIG
                     EVVARGDNVMLGYWNRPEETSQALRGGWLHTGDAGYMDEDGFVFLVDRLRDMIVS"
     CDS_motif       complement(4412..4498)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS00700_0002"
                     /evalue="9.30E-09"
                     /label="NRPS-A_a6"
                     /locus_tag="JJ691_RS00700"
                     /protein_end="371"
                     /protein_start="342"
                     /score="27.6"
                     /tool="antismash"
                     /translation="PRGDIGEVVARGDNVMLGYWNRPEETSQA"
     CDS_motif       complement(5009..5062)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JJ691_RS00700_0001"
                     /evalue="4.90E-06"
                     /label="NRPS-A_a3"
                     /locus_tag="JJ691_RS00700"
                     /protein_end="172"
                     /protein_start="154"
                     /score="19.2"
                     /tool="antismash"
                     /translation="IFYTGGTTAQPKGVMLSH"
     misc_feature    5611..5625
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.37"
                     /tool="antismash"
     misc_feature    complement(5748..5761)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 20.57"
                     /tool="antismash"
     misc_feature    5862..5880
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.74"
                     /tool="antismash"
     misc_feature    complement(5866..5884)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 28.35"
                     /tool="antismash"
     misc_feature    5869..5887
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 18.26"
                     /tool="antismash"
     gene            6122..7339
                     /locus_tag="JJ691_RS00705"
                     /old_locus_tag="JJ691_01400"
     CDS             6122..7339
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1137: Major
                     facilitator superfamily MFS 1"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155347.1"
                     /locus_tag="JJ691_RS00705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01400"
                     /product="MFS transporter"
                     /protein_id="WP_211766837.1"
                     /transl_table=11
                     /translation="MATEVTDFYGRRYRVGESDRELLGHSRNWVLAAACVAMMVTGAGQ
                     YGFGLIVGGGQYWLLAIWVATQAVAVFPLALLRERLTVRPPVAMVAGAVLTAVGDLFAG
                     PWSAVLGGLGAAIVYGTCLAVVAKWFPERRTQLGLVSGSFAAGAVLFATPLPIIAVVVI
                     TVCGFFLKEPPKQWWPQSPDPRTWALDKNVNLSLRHSRPAIRRYTPGELLHCPTYALMY
                     VLVACAAAAWLFDVAFMAAFVTTSGWGYAFAVVAVCLLTLSSGVARWATGWAGERFGVG
                     RVVRGALGLGALGQLLLIVAGQQQTPVLLALAALLVGAGAGCCYALLPALVEVHFGDQA
                     GLLNFGLVYSAKAVGGIVGVGVAASIVGLYGYAAGFLLAAGLGVVAAVASGLLRQPGVP
                     RLLVPA"
     gene            7384..8244
                     /locus_tag="JJ691_RS00710"
                     /old_locus_tag="JJ691_01410"
     CDS             7384..8244
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010235011.1"
                     /locus_tag="JJ691_RS00710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01410"
                     /product="LysR substrate-binding domain-containing protein"
                     /protein_id="WP_211766838.1"
                     /transl_table=11
                     /translation="MFKPAQLESFLAVAQTLSFTQAADELGVRQSTISQHVRQLEAIVG
                     KQLFLRDTHTVELTPEGEAMVGFARTIVDTGREAVSFFAGPQLRGRLRFGASEDFVATY
                     LTDVLRDFRRRHPAVELELTVGLSGELHRKLEARQLDLVFGKRQLGAVHGQLVWRDRLV
                     WVGAEGTKVDPTAPVPLILYPEPSVSRAQALETLQWHGRQFRVACTSTSLSGLRAAVLA
                     GLGVTAHTRSLIPHDLVELGPQHGLPALGEIEFVLSPPPRLRTEPARALGAAIVADANR
                     LRRAR"
     gene            8285..8833
                     /locus_tag="JJ691_RS00715"
                     /old_locus_tag="JJ691_01420"
     CDS             8285..8833
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS00715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_01420"
                     /product="hypothetical protein"
                     /protein_id="WP_211766839.1"
                     /transl_table=11
                     /translation="MGRRFGGTTTVDQVLRELRRGDFLHPDVRVVCQRLSRDRGRPLHL
                     IPLPLRTSISGAWLGMPDADYVVYQSVGSSPLHQIHVIWHEIGHMLLPGHARTCDVDPA
                     TRDVLMKVLNALVPNLSPAVLSRILGRGGFTDQQEIEAEVFAGAAVCALGEPAPDSGHR
                     DLTEAEAQIVDALVRELRV"
     gene            8836..9927
                     /locus_tag="JJ691_RS00720"
                     /old_locus_tag="JJ691_01430"
     CDS             8836..9927
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042915.1"
                     /locus_tag="JJ691_RS00720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01430"
                     /product="MAB_1171c family putative transporter"
                     /protein_id="WP_211766840.1"
                     /transl_table=11
                     /translation="MLTFALVVTVVVAAVALTTRLRMLVRVTVDRRPGHVLALGFAAWF
                     LAVPLEIATIAVEVDRWAGWALTWPLLRVIACAGGFFTQTFFRLATSDRADPAQRARVT
                     WLVRRSALFGVTAVAVGLILFAAMPHDVLFASGPAGRMITPGPVYPVAELANLVILSYF
                     AYAIASITSESWRWATKADVPWLRRGLRIHTVGCVFGLVYCVHVAVYQIAEMAGIFPPW
                     SELEGDGAFVTMCLLPAFVGVTAPMWGPRLDGLARAARHYRHRRLLYPLWRRLSGSVVR
                     LDPPKTEWHDRLRLWPGQQHALVYRRVIELWDGLLASHPTMFGGGGLEDPDLARDIDWW
                     LEIARATQVRPIADVLAEYQGQL"
     gene            10001..10870
                     /locus_tag="JJ691_RS00725"
                     /old_locus_tag="JJ691_01440"
     CDS             10001..10870
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013674905.1"
                     /locus_tag="JJ691_RS00725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01440"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_211766841.1"
                     /sec_met_domain="phytoene_synt (E-value: 4.4e-78, bitscore:
                     261.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.9e-56,
                     bitscore: 190.8, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDELDAAGIRDPQLRACYLRCKRLLAEHDKSYYLASLLLPPARR
                     PFVHAIYGFARHADEMVDGADAAGFEPWRDRILAELTAGETEDEFGRALLHTIRTWDIP
                     LRHIEDFLAAMASDLTVTSYETYADLEVYMHGAAATLALQLAPVLGARTDEAVEAMRLM
                     GIAFQLTNILRDVGDDLRRGRVYLPGEDLRRFNVTEIEPGRRFRELIKYEIARTRSFYR
                     RARAGMPLLDPVGRPTALAGMRLYGGILDAIERSGYDVIAQRVSVGTARQLAIAVPAYL
                     RSLLARVS"
     gene            complement(10847..11314)
                     /locus_tag="JJ691_RS00730"
                     /old_locus_tag="JJ691_01450"
     CDS             complement(10847..11314)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS00730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_01450"
                     /product="hypothetical protein"
                     /protein_id="WP_211766842.1"
                     /transl_table=11
                     /translation="MLSFRDKLNAAFDAVRPNGPDGPEYRNTEVAAALGELGVKVTGSY
                     LGLLRNGERDNPTVNVVQGLAAFFDLDPVYFLAPTTPQAAEKVAGIHRDLMRLAEWRDK
                     GVLAFALRAMLLEQDSGQLAEAAKVLLEQVLELRRTDRESADQDSGNPGQQ"
     gene            complement(11585..12118)
                     /locus_tag="JJ691_RS00735"
                     /old_locus_tag="JJ691_01460"
     CDS             complement(11585..12118)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JJ691_RS00735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JJ691_01460"
                     /product="hypothetical protein"
                     /protein_id="WP_211766843.1"
                     /transl_table=11
                     /translation="MIRCLVAWALRRPEDPSAFAYGRGFRPLVHVLLAMSIVEGLVVEF
                     VLGAVLPGTFWPWLLLALHVYGVLWILGLLASLTTRPHQLLPDALVLRDSTFSELTIPL
                     SAITSVKPHARPNILRSGLKVDGDTALYAYGDANIAVHIDPVDDPRLAGVRHLHITVDE
                     PRRFLAAMERQFVS"
     gene            complement(12115..12840)
                     /locus_tag="JJ691_RS00740"
                     /old_locus_tag="JJ691_01470"
     CDS             complement(12115..12840)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024803.4"
                     /locus_tag="JJ691_RS00740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01470"
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_211766844.1"
                     /transl_table=11
                     /translation="MRIGELAGLAGVTPRTVRHYHRIGLLPEPRRRENGYRSYELRDLV
                     LLLRARRLAELGLSLEEVADALSGDRNRDLVEILREIDGDLAAQQERIAGQRAAIADLL
                     AADGDLRSPALLTVIDSLTDYPGRDREILAAEVMESMTGNLDLYHSVFADSDLRERMLA
                     VQADFERLVDASPNDPAVTDIADRARDFGPAIVAMLPPELQAVDADPDALLAAISADMS
                     PAQARCLRLMFSYWKQDMP"
     gene            complement(12883..13767)
                     /gene="sucD"
                     /locus_tag="JJ691_RS00745"
                     /old_locus_tag="JJ691_01480"
     CDS             complement(12883..13767)
                     /EC_number="6.2.1.5"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="sucD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943411.1"
                     /locus_tag="JJ691_RS00745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01480"
                     /product="succinate--CoA ligase subunit alpha"
                     /protein_id="WP_211766845.1"
                     /transl_table=11
                     /translation="MAIFIDEGSRVVVQGMTGAEGSKHTARMLRAGTTVVGGVNARKAG
                     QRMDFDGTSLPVFGTVAEAVFQTGADVSVLFVPPAFARDAAIEAIDAGIGLAVVITEGI
                     PVHDTAAFWAHAVESGGRTRIIGPNCPGVISPGKSNAGIIPADITKPGRVGVVSKSGTL
                     TYQLMHELRDFGCSTAVGIGGDPIVGTTHIDALQAFQDDPETELIVMIGEIGGDAEERA
                     AAYISEHVTKPVVGYVAGFTAPEGKTMGHAGAIVSGSAGTAEAKKVALEAAGIAVGRTP
                     GETARLARDLLTG"
     misc_feature    complement(13603..13605)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    13762..13772
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(13769..15007)
                     /gene="sucC"
                     /locus_tag="JJ691_RS00750"
                     /old_locus_tag="JJ691_01490"
     CDS             complement(13769..15007)
                     /EC_number="6.2.1.5"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006099 - tricarboxylic acid cycle
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="sucC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009943410.1"
                     /locus_tag="JJ691_RS00750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01490"
                     /product="ADP-forming succinate--CoA ligase subunit beta"
                     /protein_id="WP_256449353.1"
                     /transl_table=11
                     /translation="MSRATREHFATLALSGKRTRRRDQPPPAQRSQEGRTLDLFEHEAR
                     DLFARHGVPVPPGEVTDTPAGAYAAAVAIDGPVVVKAQVKTGGRGKAGGVKLAGTPAEA
                     RAAAEAILGMDIKGHTVHKVLVTAASEIADEYYFSFLLDRANRTFLAMASAEGGMDIEE
                     VAATRPEALIRRPVRDMNLALAGDIAQAAGLPAASAEVIVKLWDVFVREDCTLVEVNPL
                     VRTESGEIIALDGKVTLDDSAAFRHSGRPADSTAGDPLEQAARAKGLNYVKLTGDVGVI
                     GNGAGLVMSTLDVVAQAGGAGPANFLDIGGGASAQVMADGLEIILGDPDVRSVFVNVFG
                     GITACDAVADGIVRALDMLGPRATKPLVVRLDGNNVKRGRQILTEAGHPLVTMVETMDD
                     AAGTAARLAARGA"
     misc_feature    complement(15039..15057)
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 20.75"
                     /tool="antismash"
     misc_feature    15042..15060
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 22.41"
                     /tool="antismash"
     gene            15092..16831
                     /locus_tag="JJ691_RS00755"
                     /old_locus_tag="JJ691_01500"
     CDS             15092..16831
                     /GO_function="GO:0030976 - thiamine pyrophosphate binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055: pyruvate oxidase/decarboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020659796.1"
                     /locus_tag="JJ691_RS00755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01500"
                     /product="thiamine pyrophosphate-binding protein"
                     /protein_id="WP_211766847.1"
                     /sec_met_domain="TPP_enzyme_N (E-value: 1.5e-51, bitscore:
                     173.6, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.9e-28, bitscore:
                     97.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGTEPVAEAQTATSRTANGSGPAPATISGGHLVAKALRAEGIDT
                     IFTLCGGHIIDIYDGCVDEGIEVIDVRHEQVAAHAADGYARVTGKPGCAVVTAGPGTTD
                     AVTGVANAFRAESPMLLIGGQGALTQHKMGSLQDLPHVDMMAPITKFAATVPDTARAAD
                     MVSMAFREAFNGAPGPSFLEIPRDVLDNKVPVEKARVPQAGHYRASTRQAGDPAAVEKL
                     ADLLAHAKKPAILLGSQVWTTRATASAIELVRTLNIPAFMNGAGRGTLPPGDPHHLQLS
                     RRYAFDNADVIVIVGTPFDFRMGYGRRLSAKATVVQIDLDYRTVGKNRDIDLGIVGDAD
                     LILAAVTAAASGRVDNGATGRKPWLEELHKVEEQARQKRLPQLRSDASPIHPYRLVHEI
                     NEFLTEDSIYIGDGGDIVTFSGQVVQPKSPGHWMDPGPLGTLGVGIPFVLAAKHARPDK
                     EVVALFGDGAFSLTGWDFETLVRYNLPFVGIVGNNSSMNQIRYGQAQKYGLARERVGNT
                     LGDVHYDQFAKMLGGYGEEVRDPADIGPALLRARESGKPSLINVWVDPDAYAPGTMNQT
                     MYK"
     gene            16848..18077
                     /gene="frc"
                     /locus_tag="JJ691_RS00760"
                     /old_locus_tag="JJ691_01510"
     CDS             16848..18077
                     /EC_number="2.8.3.16"
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /GO_function="GO:0033608 - formyl-CoA transferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009636 - response to toxic substance
                     [Evidence IEA]"
                     /GO_process="GO:0033611 - oxalate catabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="frc"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1189: L-carnitine dehydratase/bile acid-inducible"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004562330.1"
                     /locus_tag="JJ691_RS00760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01510"
                     /product="formyl-CoA transferase"
                     /protein_id="WP_211766848.1"
                     /transl_table=11
                     /translation="MGKALEGVRVLDMTHVQSGPSSTQLLAWLGADVIKLETPGRGDIT
                     RGQLRDLPDVDSLYFTMLNANKRSLTLNMKSEEGKQIFTRLVSEVDVLVENFGPGVVDR
                     FGFTWERLSELNPRLVYASIKGFGPGRYADFKAYEVIAQAMGGSMSTTGFEQGPPTATG
                     AQIGDSGTGIHLVAAILAALYQRTNSGRGQRVQVAMQDAVLNLCRVKLRDQQRLAHGPL
                     GEYPNESFGDEVPRSGNASGGGQPGWAVRCAPGGPNDYIYVIIQPPGWRPITELIGKPE
                     LADDPQWATPEARLSKLDKVFAMVEDWTSGLSKWDVMERLNAANVPCGPILSTRELIED
                     ETLAELGSVVPVQHPERGEYKTVGCPLKLSDSHVEITRSPLLGEHNAEVLGELGYGPDQ
                     LERLRAAGVI"
     gene            18090..20228
                     /locus_tag="JJ691_RS00765"
                     /old_locus_tag="JJ691_01520"
     CDS             18090..20228
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009155340.1"
                     /locus_tag="JJ691_RS00765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JJ691_01520"
                     /product="acetate--CoA ligase family protein"
                     /protein_id="WP_211766849.1"
                     /transl_table=11
                     /translation="MSNYDREAVQRVLAQVAADGRDSLTAPEGKIVCDAYGISTPDEGL
                     ATSSEQAVELAERMGFPVVLKIVSPDILHKTEAGGVLVGLADAGQVAHGYRTIIANAKS
                     YNPNAAIVGVQVQQMLPAGQEVIVGATTDRTFGKIVAFGLGGVLVEVLKDVTFRLAPTD
                     REQALSMIDGIAAAEILRGVRGAEPADRDAIADLITRVSDLVTDFPQLSEVDLNPVLAT
                     PTGATAVDVRVLVDPDAAAEPTRFSQQEILAAMNRIMKPAAVAVIGASAEDGKIGNSVM
                     KNLVNGGYAGDIYPINPKAAEILERKAFASIADVPGDVDVAVFAIPAKFVPQALREAGE
                     KGVAGAILIPSGFGETGNHELQDEVVRIAREHNVRILGPNIYGYYYTPEHLSATFCTPY
                     DVQGGVALSSQSGGIGMAILGFSRSAQMGVSAIVGVGNKADIDEDDLLTFFEHDDNTKL
                     IAMHLEDLKDGRSFAETAKRVSRKKPVVVLKAGRTAQGAKAASSHTGALAGDDKVYDDI
                     LRQSGVVRAPGLNDMLEYARGVPLLPTPKGENVVIITGAGGSGVLLSDACVDNGLTLMS
                     IPDDLDAAFREYIPPFGAAGNPVDITGGEPPSTYRNTIALGLADERVHALILGYWHTIV
                     TPPMVFAELVVDVVEQYREHGIHKPVVASLSGDVEVERAAEFLYRHGIVAYPYTTEKPV
                     AVLGAKYRWAREAGLMEG"
     misc_feature    complement(20254..20269)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.75"
                     /tool="antismash"
     misc_feature    complement(20539..20552)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.04"
                     /tool="antismash"
ORIGIN
        1 cccttggcgg cgttgcagcg ggcgcagcag gccacggtgt tgagccagct ggtgcgggcg
       61 ccgccgcgag agaggggcag gacgtggtcg acggtgtcgg cgggccggcc gcagtaggcg
      121 cagcggtggt gatcccgttg cagcacaccg cgacgggacc agcggggcgg gcggctgtag
      181 cgccacttca tgacgacgta gcgaacgagc cggacgaccc gcggcagcgg gtagtgcccg
      241 aacttggcgc cggtgtcggc ctcgtggatc tcggcgaccc ggcggacgag catgcggacg
      301 gcatggggga ccgacacggt gtgcagcggt tccatgctcg cgttgagcac cagtacgccc
      361 acggcggacc acctcccttc gaggcgcaat cgtcgccgtg gcaaggggag gagtcaacgc
      421 cattacggat cagtccaaag aggacagtgc gccgaagacg gcccggatcc ggggcaggtg
      481 ttcccgcccg cgccgggtgc cgatgtgcac ggagttgacg acgggctgcg cgggccggtg
      541 cagcacggcc agtcggccgg cggcgaggtg ctcctcgacc agatagtgcg gggcgacggt
      601 caggccggcg ccggcgagca cggcggcgac gacggaacgg aagtcgttga cgatgagcgc
      661 gggcgcgggc ggccgaatgg cccagcactc ccggaaatac cgccgagcca tgggcatctc
      721 ctcggagtag ccgacgaaac gccgctcctg ccccggttcg tacggctcgt cgccggccgg
      781 cccgaccagc aggaaccgct cctccaacag cggcacgaga tacatccgcc gggtgggcac
      841 gccctcgatc ttggtcagca gcgccacgtc gatctcgtcc cgcagcacgg cctgcacgag
      901 atcgggcgac agcccgaccc ggcaccgcac ggtgagccct tcggccagca gcggcgacat
      961 ccgggtgacc acgaaccgtt cgagcaggtc gacgggcgcg ccgacaaaaa cggggccggc
     1021 gccggacagg gtggcggagc gcagaccgtc cagggcgccc tcgagggcgt cgatgtgctc
     1081 ggcgacctcg gcggccaggc tgtgcccggc ctcggtgggc gtgatgcccc gcccggcccg
     1141 tcggaacagc ggccgcccga ccgattcctc gatggccttg agatgatgcg acacggcggg
     1201 ctgggacagc cgtagcgcct cggccgcccg ggcgaccccg ccggtccggt acacgctcag
     1261 gaacgaccgc agggcaacca gttcgggacg gttcgacacc cgaaccagct tatttcaccc
     1321 cggccagcgc gaagaactcc tgccgcgacc gcgcgtcgga acgcagcgtg ccgagcatgg
     1381 tggaggtgac ggtgctggag ccggaggccc gcacgccgcg cagggtcatg caggtgtgct
     1441 ccgcctcgat gaccacgccg acgcccttgg gctgcagctg ggccgacagc cagtcggcga
     1501 cctgcttggt cagccgttcc tgcacctgcg gccggctggc gaagtgctcg acgacacggg
     1561 ccagtttgga cagtccgagg atgcgcgcgt cgggcaggta gccgacgtgc gcgacgccga
     1621 cgaacggcag caggtggtgc tcgcacaccg accgcaccgg gatgctgcgg gccagcacca
     1681 gttcgtcgta gccttcgtcg ttggggaacg tggtcaggtc gaacgggcgc ggcgagaaca
     1741 gctcggcgta ggcccggacc atccggccgg gcgtggcgcg caggctctcg ttgtcggtgt
     1801 cgacaccgag ggcgcgcagc aggtcgccgg cggcgcgttc ggcggcgtcg aggtcgacgc
     1861 cggcagtgtg ctcgggcacg acccgtaacg cgtgcatgcc gcctccttcg ctccagtttc
     1921 gccaatagat gttggtctta tcaacgtcgc aggtcaagaa gtgtggttgc ggacacgctc
     1981 gtaggcgata ttctggttag ggtgagcacc gatcgggcga tcagcgccgt ggccgccctc
     2041 gacgacgacc tgcgtcgcgg catgttcgac ttcatccgcg ccgcccgcca cccggtgacc
     2101 agggacgagg cagcctcggc ggtcggcatc tcccgcaagc tggccgcgtt ccacctggac
     2161 aagctggtcg acgccggcct gctacgggcc cattacgagg gcgcgggccg ggtcggccgg
     2221 gcgcccaagg tgtacgagcc ctcggacgtg gacgtgcggg tcagcatccc ggcccggcag
     2281 tacgacctgc tggccgacat cctgatcgac gcggtgctga gcgacgaccc gcgcggcgcg
     2341 gccgagccga tcgccgccga gcgcggccgc gagatcgggg tggccgagcg cgagggggag
     2401 cggccggggc ggctgggcac cgagcgggcg ctgacgatga cctgtcggct gctggcccgg
     2461 cacggcttcg agccgctgcg ggacacaccg accacggtgc ggttgcgtga ctgcccgttc
     2521 catccgctcg cgggcaaggc tcgcgacctg gtgtgcggca tcaaccgggc gttcctggcg
     2581 gggatgatcg acggcctcga ggcccggacg gtggaggcgg tgctcgcgcc gggcggcgcc
     2641 ggggcctgct gcgtcgagct gcggccgcgg caggaggact gaatttccct cccattggaa
     2701 tgtatatccg atgggggact tgccgcaagg ccccggggtg cccgcacaat cacctcccgt
     2761 aagtccacga accacggggg tatttcgcat gcgcgtgctg ctgtcgacca tcgggtcgcg
     2821 cggtgacgtc caaccggtcg cggccctggc tttgcggctg cgggaaatag ggcacgaggc
     2881 gcggctgtgt gcgccgccgg atttccggga atggatcgaa gggctgggca tcgacttcgt
     2941 gccgctcggt cccgaagttc ggcccgcgac caagccggac tccgaggtcc ggcggctcgg
     3001 ggccaccccg gaggggcgga aacagctgat ggaaggcacg gtggccaccc agttcgagac
     3061 gctgctgccg gccgccgacg gctgcgacgt cgtgctgggc tggtcggcac tccagttggc
     3121 cgcgccgtcc gtggcggaga aactcggtat tcgccacgtc tacgccgtat tctgccccaa
     3181 tcaactccct tccgggcagc atgcgccggc gccggtgccc gcctgggaac agccgacggg
     3241 cgtcgacaat cgcaccttgt gggagctgga atcgcagcgc tggaacgagc agtggcggcc
     3301 ggcggtcaat tccaaccggg aaaagatcgg gttgcctccg gtcgaggacg tgctcagcca
     3361 catgaactcg ccgcggccgt ggctggcggc ggacccggcg atcgggccgt ggccggagcc
     3421 gagtgacctc gatgtggtgc agacgggcgc gtggctgatg aaggacaccc gtccgctgcc
     3481 cgacgagctg gcccggttcc tggacgccgg cgagccgccg gtgttcttcg ggttcggcag
     3541 caccggcacc gccgggctgg aggtcgccca gacgatgctg gagtcggcgc gggcgctcgg
     3601 ccggcgggcg gtgatctcca gcggctggtc ggacctggag ctggcggccg gcgccgagga
     3661 cgcgattgtc atcggcgaag ccaacttcca gggcttgttc ccacgggtgg cggcggccgt
     3721 gcaccacggc ggatccggca ccaccacggt gacctcgatc tcgggcacgc cgcacgtgat
     3781 cgtgccgcac cgctacgacc agttctactg ggctcagcgg gtcgaagagc tcggcatcgg
     3841 cgctgagcac cggggcaccg agccgaccgt ggcgtcgctg accgcggcgc tcgaccgcgt
     3901 gctgcggccc gaggtggcgg cgaacgcgaa ggcggtcgcc gccacgatgg cgtccgacgg
     3961 cgtggagatc gccgccgacc tgctcgtcaa cggctaggaa acctcaggaa acactgcggt
     4021 cccggccggc ccagtgccgg gaccgcagct cccgcttgag gaccttgccc gcccccgaca
     4081 gcggcagcac ctcgatgaac tcgatgctgc gcggggcctt gtagccggcg atgtgctcct
     4141 tgacgtgatc gcgtagctcg tcgacggtcg gccgtacacc gtcgactgcc accaccacgg
     4201 cgtgcacgcg ctcgccccac tccccgtccg gcacgccgat caccgcgcac gcggccaccg
     4261 ccgggtgctt ggccagggcg ttctccacct cggccgagta cacgttctcg ccgccggaca
     4321 cgatcatgtc ccgcagccgg tcgaccagga agacgaagcc gtcctcgtcc atgtagccgg
     4381 cgtcgccggt gtgcagccag ccgccgcgca gggcctggga cgtctcctcg ggccggttcc
     4441 agtagccgag catcacgttg tcgccgcggg ccacgacctc gcctatgtcg ccgcgcggca
     4501 cctcgacatc gtgttcgttc acgatgagaa cttcgacgtg cggcgcggcg cggccggcgg
     4561 atcggcgcag gcggggcacc tggtgcgcgt cggggccgag cagggtggct atcggcgcca
     4621 gctcggtcat gccgtaggcc tgcgtgaact cggtgtcggg caagcgtttc gtcgagcggt
     4681 cgaggagggc gtccgagatc ggcgacgcgc cgtaggccag ccggcgcagg ctggacaggt
     4741 cgtgctcggc cgtcgccggc gagtcgacca gcaactggag catcgtcggg accaccagcg
     4801 tgtccgtcac ccgatgccgc tcgatcgcgt cggccatacc caccggagtg aacggcgaca
     4861 gcagcacgtg cgtgccgccg acgacgttgt gcagcagcca gccgctgagg gcggcgaggt
     4921 ggaacatcgg cgccacgtgc aggtatcgac cgccgggcac cgtgttggtg gcggccaccg
     4981 cgcccagcgc cgacaccatc atgttgttgt ggctgagcat cacgcccttg ggctgcgccg
     5041 tggtgccgcc ggtgtagaag atgccggcca gcgagtcacc gccgcgccgg gcgtccggcg
     5101 ccggctcgtg gtcggcgatc agccggtcga cggccgccgc accctcgatg acgttttcca
     5161 gacaaggggc caattcccgc agttgcggcg ccatcggcgc gaacgtgtcg tccacgtaca
     5221 gcacgcgggt gtccgagtcc cggagcgaga acgcgatctc gttcgccgac cacctcgtgt
     5281 tgatcggcat cagcaccgcg tccgcccacg gcaccgccag cagaaactcg tgatatatgt
     5341 ccgaattcag cgccagtagg ccgatccggt caccttgccg gacccccagg tcggtcagcg
     5401 ccgccgccag ccgggccacc cgatccacgc tctcggccca ggtccgcacc cggtcgccga
     5461 agatcgtcgc cgtcaggtcc ggggtctgct gcacggcgtg gtgcacgctc tgggtcagct
     5521 gcacgggtcg gcctccatcc gtatcgacct ccattggtag ccgatgcggc ggacccgggg
     5581 cgacagccga gacccgaggg gcggtttctc ggtccctatc ggccacgaag tggttgtcag
     5641 ggcagagttt tccggatgat cgggtctggg ggccggtcag ggcaagggga gggccgcacg
     5701 gctggatccg ctcgccgcaa cggatctgcg gcagcggcac ctcgacgtcg gattcggtcc
     5761 actgtggagg gatatcggcc ggggccgcca tcggatccag tcggccgcat cccgtgtgac
     5821 ctgcccgcct tgccgtctgg cgctggtcga cgctatacaa cgtatcacat actgtataca
     5881 atcgaacggc gggaatgtgg tgaagacctc agtaagaagg cgggacgggt ggttgacgac
     5941 ccaggtcgat ggctgactga ccgcggccgg ccaccgggca ggtcggtggg actgggcgac
     6001 cggcaaggaa gcggctgccg aggccggggg acgcgtgaac ggacagggaa tcggaccaga
     6061 tcgatcggtc ggcggggtgg ggccgggcgg tgtgatcgac gactgcgggc aggtgagacc
     6121 gatggcaacc gaggtgaccg acttctacgg ccggcggtac cgggtcggcg agagcgaccg
     6181 ggagctgctg ggccattcca ggaactgggt gctggcggcg gcgtgcgtgg cgatgatggt
     6241 caccggcgcg ggccagtacg ggttcgggct gatcgtgggc ggcgggcagt actggctgct
     6301 ggcgatctgg gtggcgacgc aagcggttgc ggtgtttccg ctggcgttgc tgcgggagcg
     6361 gctgaccgtg cggccgccgg tggcgatggt ggcgggcgcg gtgctgacgg cggtggggga
     6421 tctgttcgcg ggaccctggt cggcggtgct gggcggactg ggcgcggcga tcgtctacgg
     6481 cacgtgcctc gcggtggtgg cgaagtggtt cccggagcgg cgaacgcagc tgggcctggt
     6541 gagcgggtcg ttcgcggcgg gggcggtgct gtttgcgacc ccgttgccga tcatcgcggt
     6601 ggtggtgatt acggtgtgcg gcttcttcct caaggagccg ccgaagcagt ggtggccgca
     6661 gagcccggac ccgaggacat gggcgctgga caagaacgtg aacctcagcc tgcggcacag
     6721 ccgcccggcg atccgccggt acacgccggg ggagctgctg cactgcccga cgtatgcgct
     6781 gatgtacgtg ctggtggcct gcgcggcggc ggcctggctg ttcgacgtgg cgttcatggc
     6841 ggccttcgtg accaccagcg gctgggggta cgccttcgcg gtggtggcgg tctgcctgct
     6901 gacgctgtcc agcggcgtgg cccggtgggc gacgggctgg gccggggagc gcttcggtgt
     6961 gggccgggtg gtccgcgggg cgctgggcct gggcgctctc ggccagttgc tgctgattgt
     7021 ggccggccag cagcagaccc cggtgctgct ggcgttggcg gcgctgctgg tcggcgcggg
     7081 cgccggctgc tgctacgccc tgctgccggc cctggtcgag gtgcacttcg gcgatcaggc
     7141 gggactgctg aacttcggcc tggtctacag cgcgaaggcg gtcggcggga tcgtcggcgt
     7201 cggcgtggcg gcgtccatcg tcggcctgta cggctacgcg gccgggttcc tgcttgcggc
     7261 cggcctcggc gtggtggcgg cggtggccag cggcttgctg cgccaaccgg gcgtgccccg
     7321 gctgctggtg ccggcctgac cgagcatcct tcgtgttgac cgggtgctga ctacgctggg
     7381 ccgatgttca agccggctca gctggagagc ttcctggccg tcgcgcagac gctcagcttc
     7441 acccaggccg ccgacgagct cggcgtccgc cagtcgacga tcagccagca cgtgcggcag
     7501 ctggaggcga tcgtcggcaa gcagctgttt ctgcgggaca cgcacaccgt cgagctgacg
     7561 ccggagggcg aggccatggt cggcttcgcc cgcaccatcg tggacaccgg ccgggaggcg
     7621 gtcagcttct tcgccgggcc gcagctgcgc gggcggctgc ggttcggcgc gtcggaggac
     7681 ttcgtcgcca cctacctgac cgacgtgctg cgggacttcc ggcggcggca tccggcggtg
     7741 gaactggagc tgacagtcgg gctgagcggc gagctgcacc ggaagttgga agctcgccaa
     7801 ctggacctgg ttttcggcaa acggcaactg ggcgcggtgc acggccagct ggtgtggcgg
     7861 gaccggctgg tctgggtcgg ggccgagggg acgaaggtcg acccgaccgc gccggtgccg
     7921 ctgatcctgt acccggagcc gagcgtcagc cgcgcgcagg cgttggaaac ccttcagtgg
     7981 cacggccggc agttccgcgt cgcctgcacc agcaccagcc tgagcgggct gcgcgcggcc
     8041 gtgctggccg gactgggcgt gaccgctcac acccgcagcc tgatcccgca cgatctcgtg
     8101 gaactcggtc cgcagcacgg tcttccggcg ctcggcgaga tcgagttcgt gctgtcgccg
     8161 ccgccgcggc tgcggaccga acccgcgcgg gcgctggggg cggcgatcgt cgcggacgcc
     8221 aacagactgc gccgcgcacg ctagaatggc cgcctacggt cgcatcgagg ggagtgccct
     8281 ccacatgggt aggcggttcg gcggaaccac cacggtcgac caggtcctgc gtgaactgcg
     8341 gcgcggtgac ttcctgcatc cggacgtacg cgttgtgtgc caacggctgt cgcgggaccg
     8401 cggccgcccg ctgcacctga tcccgctgcc gctgcgcacc tcgatcagcg gcgcctggct
     8461 gggcatgccg gacgcggatt acgttgtcta ccagtcggtc ggatccagcc cgctgcacca
     8521 gatccacgtg atctggcacg agatcgggca catgctcctg cccggtcacg cccgcacctg
     8581 cgatgtggac ccggcgaccc gggacgtgtt gatgaaggtg ctgaacgcgt tggtgcccaa
     8641 cctcagtccg gccgtgctga gccggatcct gggccgtggc ggcttcacgg accaacagga
     8701 gatcgaggcg gaggtgttcg ccggcgccgc ggtgtgcgcc ctgggcgagc cggccccgga
     8761 ttcggggcac cgcgacctga ccgaggccga ggcgcagatc gtggacgcgc tggtccgaga
     8821 actgcgcgtc tgaccgtgct gaccttcgcg ctcgtggtga ccgtggtggt ggccgccgtc
     8881 gcgctgacca cccggctgcg catgttggtg cgggtgaccg tcgaccggcg gcccggtcat
     8941 gtgctggcgc tgggcttcgc cgcgtggttt ctggctgtgc cactggagat cgccaccatc
     9001 gcggtggagg tcgaccggtg ggccggctgg gcgctgacct ggccgctgct gcgggtcatc
     9061 gcctgcgccg gcgggttctt cacccagacc ttcttccggc tggccacctc cgaccgcgcc
     9121 gatccggcgc agcgtgcccg ggtcacctgg ctggtgcgcc gttcggccct gttcggcgtg
     9181 accgcggtgg ccgtcggtct gatcctgttc gccgcgatgc cgcacgacgt tctcttcgcc
     9241 agcgggccgg ccggtcggat gatcacaccg ggtccggtgt atccggtcgc ggagctcgcg
     9301 aacctggtca tcttgagcta tttcgcctac gccatcgcga gcatcacctc ggagtcgtgg
     9361 cggtgggcga ccaaggccga cgtgccgtgg ctgcggcggg gtctgcgcat ccacaccgtc
     9421 ggctgcgtgt tcgggctcgt ctactgcgtg cacgtggccg tgtaccagat cgccgagatg
     9481 gccgggatct tcccgccgtg gtcggagctg gagggtgacg gcgcgttcgt cacgatgtgt
     9541 ctgctgccgg cgttcgtcgg cgtgaccgcg ccgatgtggg ggccgcgact ggacggcctg
     9601 gcccgcgcgg cccggcacta ccggcaccgg cggctgctgt atccgttgtg gcggcggctg
     9661 agcggttccg tggtgcggct ggatccgccg aagaccgagt ggcacgaccg gttgcggctg
     9721 tggccggggc agcagcacgc gctggtctac cggcgggtca tcgagctgtg ggacgggctg
     9781 ctggcctcgc atcccaccat gttcggcggg ggcgggctgg aggatcccga cctggcccgg
     9841 gacatcgact ggtggctgga gatcgcccgg gccacccaag ttcgcccgat tgccgacgtg
     9901 ttggccgagt atcaaggaca gttgtgaccg agcttgcgag ggcaccattg agcacagtgg
     9961 ccttggtcgc agactcgccg agcgctagcg aggtgggact gtgaccgatg agctcgatgc
    10021 cgccggcatc cgcgaccccc agctgcgcgc gtgttacctg cgctgcaagc gattgctggc
    10081 cgagcacgac aagtcgtact acctggcctc gctgctgctg ccgccggcgc ggcggccgtt
    10141 cgtgcacgcc atctacggct tcgcccgaca tgccgacgag atggtcgacg gcgccgacgc
    10201 cgccggcttc gagccgtggc gggaccggat cctggccgag ctgaccgccg gcgagaccga
    10261 ggacgagttc ggccgggcgc tgctgcacac catccggacc tgggacattc cgttgcggca
    10321 catcgaggat ttcctggccg ccatggcctc ggacctgacc gtgacctcgt acgagacgta
    10381 tgccgatctc gaggtctaca tgcacggcgc cgccgccacc ctcgcgctcc agttggcgcc
    10441 ggtgctcggc gcgcggaccg acgaggcggt cgaggccatg cggttgatgg ggatcgcctt
    10501 ccagctcacc aacatcctcc gcgacgtcgg cgacgacctc cggcgcggcc gcgtctacct
    10561 gcccggcgag gacctgcggc gcttcaacgt gaccgagatc gagccggggc gccggttccg
    10621 cgagctgatc aagtacgaga tcgcccgcac ccggtcgttc taccggcggg cccgggccgg
    10681 gatgccgctg ctggatccgg tgggccggcc gaccgcgctg gccggcatgc ggctgtacgg
    10741 cggaatcctc gacgccatcg agcgttcggg ctacgacgtg atcgcccagc gggtcagcgt
    10801 ggggacggcc cggcagctgg cgatcgccgt gccggcctac ctccggtcac tgctggcccg
    10861 ggtttcctga atcctgatcg gctgactcgc ggtcggtccg ccgcagctcc agcacctgct
    10921 ccagcaggac tttcgccgcc tcggccagct ggccgctgtc ctgctccagc agcatcgccc
    10981 gcagcgcgaa ggccagcacg cccttgtccc gccactcggc cagccgcatc aggtcgcggt
    11041 ggatgcccgc gaccttctcc gccgcctgcg gcgtggtcgg ggcgaggaag tacaccgggt
    11101 ccaggtcgaa gaacgcggcc aggccctgca ccacgttcac ggtcggattg tcccgctccc
    11161 cgttgcgcag caggccgagg taggaccccg tgaccttcac gcccagttcg cccagcgccg
    11221 cggcgacttc ggtgttccgg tactccggcc cgtcgggtcc gttcggccgc acggcgtcga
    11281 acgcggcgtt gagcttgtcc cggaagctca gcatcgcccg tcccccactc cgctcaactg
    11341 atgtccacgc accggcgtcg actgccccaa gagtagttga cacacctggt ggtttccata
    11401 gactggcagc atcgcggtca actggtcttg tcactgggga ccgcaaccag ggggagttgg
    11461 ttgagtcgaa tggacaacgc gcccggcgag gggcgggcat ggtgtccagg ggagaggtgc
    11521 gactcgacca gcggggtggt tcctgctcga cccgggggag ggccgagcag gaaccactgt
    11581 cgggtcacga cacgaactgc cgctccatgg ctgccaggaa tcggcggggc tcgtccacgg
    11641 tgatgtgcag gtggcggacg ccggccaggc gggggtcgtc gacggggtcg atgtgcacgg
    11701 cgatgttggc gtcgccgtag gcgtagaggg cggtgtcgcc gtcgaccttg aggccggagc
    11761 gcaggatgtt ggggcgcgcg tgcggcttga cggacgtgat ggcggacaag ggaatcgtga
    11821 gctcgctgaa ggtgctgtcc cgcaacacga gcgcgtcggg gagcagttgg tgcgggcggg
    11881 tggtcagcga ggcgagcagg ccgaggatcc agagcacgcc gtagacgtgc agggccagca
    11941 gcagccaggg ccagaaggtg ccgggcagca cggcccccag cacgaactcg acgaccagac
    12001 cctccacaat ggacattgcg agcaggacgt ggaccagcgg ccggaaaccg cggccgtagg
    12061 caaaggcgga cgggtcttcc gggcggcgca gggcccacgc gaccaagcag cggatcatgg
    12121 catgtcctgc ttccagtagg agaacatcag ccgcaggcag cgcgcctggg ccggggacat
    12181 gtcggcgctg atggcggcca gcagcgcgtc cggatcggcg tccacggcct ggagttcggg
    12241 cggcagcatg gcgacgatgg ccgggccgaa gtcccgggcc cggtcggcga tgtcggtgac
    12301 ggccgggtca ttgggggagg cgtcgaccag ccgctcgaag tcggcctgca cggccagcat
    12361 ccgctcccgt aggtcggagt cggcgaacac cgagtggtac aggtcgaggt tgccggtcat
    12421 ggactccatg acttcggcgg cgaggatttc ccgatcgcgg ccgggatagt cggtgaggga
    12481 gtcgatcacg gtgagcagtg ccggggagcg caggtcgccg tcggcggcga gcaggtcggc
    12541 gatggccgcg cgctggccgg cgatgcgctc ctgctgggcg gccaggtcgc cgtcgatctc
    12601 acgcaggatc tcgacgaggt cccggttccg gtcgccggac agcgcgtcgg cgacctcctc
    12661 cagcgacagc ccgagttcgg ccagccgccg ggcccgcagc agcagcacga gatcccgcaa
    12721 ctcgtagctg cggtacccgt tctcccgccg ccgcggctcc ggcagcagtc cgatccggtg
    12781 gtagtgccgc accgtgcgcg gcgtcacccc ggccagcccc gcgagttccc cgattcgcat
    12841 gggtccagta aaaaccttga cgctacgaca aggtcaagtc gatcacccgg tgagcaggtc
    12901 ccgggccagc cgggcggtct cgccgggggt gcggccgacg gcgatgccgg cggcctccag
    12961 ggcgaccttc ttggcctcgg cggtgccggc ggagccggac acgatggcgc cggcgtggcc
    13021 catggtcttg ccctcgggcg cggtgaagcc ggccacgtag ccgacgaccg gcttggtgac
    13081 gtgctcggag atgtaagcgg cggcccgctc ctcggcgtcg ccgccgattt cgccgatcat
    13141 gacgatgagc tcggtctccg ggtcgtcctg gaacgcttgc agggcatcga tgtgggtggt
    13201 gccgacgatg gggtcgccgc cgatgcccac ggcggtggag cagccgaagt cccgcagctc
    13261 gtgcatcagc tggtacgtca gcgtgcccga cttggagacc acgccgaccc ggccgggctt
    13321 ggtgatgtcg gccgggatga tgccggcgtt ggacttgccg gggctgatca cgccggggca
    13381 gttgggcccg atgatccggg tccggccgcc ggattccacg gcatgggccc agaacgcggc
    13441 ggtgtcgtgc acggggatgc cctcggtgat caccacggcc agcccgatgc cggcgtcgat
    13501 cgcctcgatg gcggcgtcgc gggcgaaggc cggcggtaca aaaaggacgg acacgtcggc
    13561 tccggtctgg aacacggcct cggccacggt gccgaagacc ggtaacgacg tgccgtcgaa
    13621 gtccatgcgc tgcccggctt tgcgggcgtt cacgccgccg acgacggtcg tgccggcccg
    13681 gagcatacgg gcagtgtgct tgctgccctc ggcgccggtc atgccctgca ccacgacccg
    13741 gctgccctcg tcgatgaaga tcgccatgtc acgctccccg cgccgcgagc cgcgcggccg
    13801 tgcccgcggc gtcgtccatc gtttccacca tggtcaccag cggatgcccg gcctcggtga
    13861 gaatctgccg gccccgcttg acgttgttgc cgtccagtcg gaccacgagc ggtttcgtcg
    13921 cgcgtgggcc gagcatgtcc agcgctcgca cgatgccgtc ggccaccgcg tcgcacgcgg
    13981 tgatgccgcc gaacacgttc acgaacacgc tgcgcacgtc cgggtcaccg aggatgatct
    14041 ccagcccgtc ggccatcacc tgggccgacg cgccgccgcc gatgtccagg aagttggccg
    14101 gcccggcccc gccggcctgg gccacgacgt ccagagtgga catcaccagc ccggccccgt
    14161 tgccgatcac gccgacgtcg ccggtcagct tgacgtagtt gagccccttg gcccgggcgg
    14221 cctgttccag cgggtcgccg gcggtggagt ccgccggccg gccggagtgc cggaacgcgg
    14281 cgctgtcgtc cagggtcacc ttgccgtcca gtgcgatgat ctcgccggat tcagtgcgca
    14341 ccaacgggtt cacctcgacc agcgtgcagt cctcgcggac gaacacgtcc cacagcttga
    14401 cgatgacctc cgccgacgcg gccggcagcc cggccgcctg ggcgatgtct ccggccagcg
    14461 ccaagttcat gtcccggacc ggacgtcgga tcagcgcctc gggccgggtc gcggcgacct
    14521 cctcgatgtc catgccgcct tcggccgagg ccatcgcgag aaaggtccgg ttcgcgcggt
    14581 cgagcaggaa cgagaagtag tactcgtcgg cgatctcgga cgcggcggtc accagcacct
    14641 tgtgcacggt gtgccccttg atgtccatgc cgagtatcgc ctcggccgcg gcccgcgcct
    14701 cggcgggcgt gccggccagc ttgacgccgc cggccttgcc gcggcctccg gtcttgacct
    14761 gggctttcac cacgaccggt ccatcgatcg ccaccgccgc cgcgtacgcg cccgcgggag
    14821 tgtcggtgac ctcgccgggt ggcaccggga cgccgtggcg ggcgaacagg tccctggcct
    14881 cgtgttcgaa cagatccaac gtgcggccct cctgtgagcg ctgcgcgggt gggggctgat
    14941 ctcgccggcg ggtgcgcttt ccgctgagcg ccaaggtcgc gaaatgttct cgcgtcgctc
    15001 tggacaccgg gccggaacag gcgtaagcat atgcctactc catatcgtat gcaatctaca
    15061 gtgcaccgcg gccggcgagg agttgaccag catggtggga acagaacccg tggcagaggc
    15121 ccagacggcg accagtcgga cggcgaacgg atccgggccc gcgccggcga cgatctcggg
    15181 cggccacctg gtcgccaagg cgctccgggc cgagggcatc gacaccatct tcaccctgtg
    15241 cggcgggcac atcatcgaca tctacgacgg ctgcgtcgac gagggcatcg aggtcatcga
    15301 cgtgcggcac gagcaggtcg ccgcgcacgc cgccgacggc tacgcccgcg tcaccggcaa
    15361 gcccggctgc gcggtcgtca ccgccgggcc cggcaccacc gacgcggtca ccggcgtggc
    15421 caacgccttc cgcgcggaga gcccgatgct gctgatcggc ggccagggcg cgctgaccca
    15481 gcacaagatg ggctcactgc aggacctgcc gcacgtcgac atgatggccc cgatcaccaa
    15541 gttcgcggcc accgtgccgg acaccgcccg cgcggccgac atggtctcga tggcgttccg
    15601 ggaggcgttc aacggcgcgc ccggcccctc cttcctggag atcccccggg acgtcctgga
    15661 caacaaggtg ccggtggaga aggcccgcgt gccgcaggcc ggccactacc gggcctccac
    15721 ccggcaggcc ggcgacccgg ccgccgtgga gaagctggcg gacctgttgg cgcacgccaa
    15781 gaagccggcg atcctgctgg gcagccaggt ctggacgacc cgggccaccg cctcggcgat
    15841 cgagctggtg cgcacgctga acatcccggc cttcatgaac ggcgcgggcc gcggcacgct
    15901 gccgcccggc gacccgcacc acctccagct gtcccgccgc tacgccttcg acaacgccga
    15961 cgtgatcgtc atcgtcggca ccccgttcga cttccggatg ggttacgggc gaaggctctc
    16021 cgccaaggcc acggtggtgc agatcgacct ggactaccgc acggtcggca agaaccggga
    16081 catcgacctg ggcatcgtcg gcgacgccga cctgatcctg gccgcggtga ccgccgccgc
    16141 gtccggccgc gtcgacaacg gcgccaccgg ccgcaagccg tggctggagg agctgcacaa
    16201 ggtcgaggag caggcccggc agaagcggtt gccgcagctg cgttccgacg ccagcccgat
    16261 ccacccgtac cggctggtgc acgagatcaa cgagttcctc accgaggact cgatctacat
    16321 cggcgacggc ggcgacatcg tcaccttctc cggccaggtg gtgcagccca agtcgcccgg
    16381 ccactggatg gacccgggcc cgctgggcac gctcggcgtc ggaattccct tcgtgctggc
    16441 ggccaagcac gcccggccgg acaaggaagt ggtggccctg ttcggcgacg gcgcgttctc
    16501 cctgaccggc tgggacttcg agaccctggt ccgctacaac ctgccgttcg tcggcatcgt
    16561 cggcaacaac tcctcgatga accagatccg ttacggacag gcccagaagt acggcctggc
    16621 ccgggaacgc gtcggcaaca cgctgggcga cgtgcactac gaccagttcg cgaagatgct
    16681 gggcggctac ggcgaggagg tgcgcgaccc ggccgacatc ggcccggcgc tgctgcgcgc
    16741 ccgcgagtcg ggcaagccgt cgctgatcaa cgtctgggtc gacccggacg cgtacgcccc
    16801 cggaaccatg aaccagacca tgtacaagtg atgtggcgga ggtcgtgatg ggaaaggcac
    16861 ttgagggcgt gcgcgtcctc gacatgaccc atgtgcagtc cggtccctcg tccacccagc
    16921 tgctggcctg gctgggcgcg gacgtcatca agctggagac tcccggccgc ggcgacatca
    16981 cccgcgggca gctgcgggac ctcccggacg tggacagcct ctacttcacc atgctcaacg
    17041 ccaacaagcg cagcctcacg ctgaacatga agagcgagga gggcaagcag atcttcaccc
    17101 ggctggtgtc cgaagtggac gtcctggtgg agaacttcgg gcccggcgtg gtcgaccggt
    17161 tcggcttcac ctgggaacgc ctcagcgagc tcaacccgcg gctggtctac gcctccatca
    17221 agggtttcgg ccccggccgg tacgcggact tcaaggcgta cgaggtgatc gcgcaggcga
    17281 tgggcggctc gatgagcacc accggcttcg agcagggccc gcccaccgcc accggcgcgc
    17341 agatcggcga ctccggcacc ggcatccacc tggtggccgc catcctggcc gcgttgtacc
    17401 agcgcaccaa ctccggccgc gggcaacggg tgcaggtggc catgcaggac gcggtgctca
    17461 acctgtgccg ggtcaagctg cgcgaccagc agcggctggc ccacgggccg ctgggggagt
    17521 acccgaacga gagcttcggc gacgaggttc cccgctccgg caacgcttcc ggcggcggcc
    17581 agccgggctg ggcggtgcgc tgcgcgcccg gcggccccaa cgactacatc tacgtgatca
    17641 tccagccgcc gggctggcgg ccgatcaccg agctgatcgg caagccagag ctggccgacg
    17701 acccgcagtg ggccacgccg gaggcgcgac tgtccaagtt ggacaaggtg ttcgcgatgg
    17761 tcgaggactg gaccagcgga ctgtccaaat gggatgtgat ggagcggctc aacgcggcca
    17821 acgtgccgtg cgggccgatc ctgtccaccc gggagctgat cgaggacgag acgctggccg
    17881 aactcggctc cgtggtcccg gtccagcatc ccgagcgcgg cgagtacaag accgtcggct
    17941 gcccgctcaa gctctccgac tcgcacgtgg agatcacccg ctcgccgctg ctgggcgagc
    18001 acaacgccga ggtgctcggc gaactgggtt acggccccga ccaactggag cggctgcgcg
    18061 ccgccggcgt gatctgaggg agtgccgcag tgagcaacta cgaccgcgag gcggtgcagc
    18121 gggtgctggc gcaggtcgcg gcggacggcc gcgactcgct gaccgcgccc gagggcaaga
    18181 tcgtctgcga cgcctacggc atcagcacac cggacgaagg cctggccacc tcctccgagc
    18241 aagccgtgga actggctgag cggatgggtt tcccggtggt gctgaagatc gtctcgccgg
    18301 acatcctgca caagaccgag gccggcggcg tgctggtggg cctggccgac gccggccagg
    18361 tggcgcacgg ctaccgcacc atcatcgcca atgccaagag ctacaacccg aatgcggcga
    18421 tcgtcggcgt ccaggtgcag cagatgctgc cggcgggcca agaggtcatc gtcggggcca
    18481 ccaccgaccg gaccttcggc aagatcgtcg ccttcggcct gggcggcgtg ctggtcgagg
    18541 tgctcaagga cgtcacgttc cggctcgcgc cgaccgaccg tgagcaagcg ctctccatga
    18601 tcgacggcat cgccgcggcc gagatcctgc ggggtgtgcg cggcgccgag ccggctgacc
    18661 gggacgccat cgccgacctg atcacccggg tttccgacct ggtgacggat ttcccgcaac
    18721 tgtccgaagt ggacctcaac ccggtgctgg ccacgccgac cggggcgacc gcggtggacg
    18781 tgcgggtgct ggtcgacccg gacgccgcgg ccgagccgac ccggttctcc cagcaggaga
    18841 tcctggccgc gatgaaccgc atcatgaagc cggccgcggt ggcggtgatc ggggcttcgg
    18901 ccgaggacgg caagatcggc aactcggtga tgaagaacct ggtcaacggc ggctacgccg
    18961 gggatatcta cccgatcaac cccaaggccg cggagatact ggagcgcaag gccttcgcca
    19021 gcatcgccga cgtgcccggc gacgtggacg tggccgtgtt cgccatcccg gccaagttcg
    19081 tgccgcaggc tctgcgggaa gcgggcgaga agggcgtggc cggcgcgatc ctgatcccgt
    19141 ccggcttcgg cgagaccggc aaccacgagc tccaggacga ggttgtgcgg atcgcgcggg
    19201 aacacaacgt gcgcatcctc gggcccaata tctacggcta ctactacacg ccggagcacc
    19261 tgtccgcgac cttctgcacg ccgtacgacg tgcagggcgg cgtcgcgctg tcctcacaga
    19321 gcggcggcat cgggatggcc atcctgggct tcagccggtc cgctcagatg ggcgtgtcgg
    19381 ccatcgtcgg cgtgggtaac aaggccgaca tcgacgagga cgacctgctg acgttcttcg
    19441 agcacgacga caacaccaag ctgatcgcca tgcacctgga ggacctcaag gacggccggt
    19501 ccttcgccga gacggccaag cgggtatcca ggaagaagcc ggtcgttgtg ctcaaggccg
    19561 gacgcaccgc gcagggcgcc aaagcggcca gctcgcacac cggagccctg gctggcgacg
    19621 acaaggtgta cgacgacatc ctgcggcaga gcggcgtcgt ccgcgcgccc ggcctgaacg
    19681 acatgctgga gtacgcccgc ggcgtgccgc tgctgcccac gccgaagggc gagaacgtcg
    19741 tgatcatcac cggcgccggc ggctcgggcg tgctgctgtc ggacgcctgt gtggacaacg
    19801 gcctcacgct gatgtccatt ccggacgatc tggacgcggc gttccgggag tacatcccgc
    19861 cgttcggcgc ggccggcaac ccggtcgaca tcaccggcgg cgaaccgccg tccacctacc
    19921 gcaacaccat cgcgctgggc ctcgccgacg agcgggtgca cgcgctgatc ctgggctact
    19981 ggcacaccat cgtcacgccg cccatggtct tcgccgagct cgtcgtcgac gtcgtcgagc
    20041 agtaccggga acacggcatc cacaagccgg tcgtggcgtc gctgtcgggc gacgtcgagg
    20101 tcgagcgggc ggccgagttc ctgtaccggc acggcatcgt ggcctacccg tacaccacgg
    20161 agaagccggt cgccgtgctc ggggccaagt accgctgggc cagagaggcg ggactgatgg
    20221 agggctgaca cacgaccagt cgggaggcat gatgccggtc cagacctagc aagcgcacgc
    20281 agatcgatca cacgccatcg gaggacacag gggacctggg gattcgcaaa gacgcgaaag
    20341 aggctctgat gaccacaagt tccaccagtt acagggagtt gactgacgac aacggcaggg
    20401 tctaccggat cggcgagagt ccccacgacc tcatgggacg ctcccgggcc tggatggtct
    20461 ggttaccctg gatcgcgatg atcgcggtga gcgtgttcga gtacggctgg ggcgccgtgg
    20521 tcggcacgct gcagacgaag aacggatggt cgctgaccga ggtgttctgg ttggcgacgg
    20581 tgtgggcggt cttccaggcc gccgtggcgt tcccggcggg tcggctgcgg gagcgcaaca
    20641 agttctcggc tcgttcggca atgttgttgg gcgcggtgtt gtcgggcgtc gggtacttca
    20701 cgatcgcctt cagcggcagt ctcgggttgg ctttcctcgg ttactcggtc tgcggcggtg
    20761 tcggcgccgg cctggtctac gccacctgca tcaacatggt cggcaagtgg tatccggaga
    20821 aacgcggcgc ccgcacgggt tttgtcaacg gcggcttcgc gtacggctcg
//
