LOCUS       NZ_CP060742            22187 bp    DNA     linear   CON 27-APR-2024
DEFINITION  Streptomyces alfalfae strain XN-04 chromosome, complete genome.
ACCESSION   NZ_CP060742
VERSION     NZ_CP060742.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces alfalfae
  ORGANISM  Streptomyces alfalfae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8254035)
  AUTHORS   Chen,J.
  TITLE     The Biocontrol and Plant Growth-promoting Properties of Streptomyces
            alfalfa XN-04 Revealed by Functional and Genomic Analysis
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8254035)
  AUTHORS   Chen,J.
  TITLE     Direct Submission
  JOURNAL   Submitted (20-AUG-2020) College of Plant Protection, Northwest A&F
            University, No. 3 Taicheng Road, Yangling 712100, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SOAPdenovo v. 2.04
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology             :: Illumina HiSeq; PacBio
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141485.1-RS_2024_04_27
            Annotation Date                   :: 04/27/2024 05:42:14
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,240
            CDSs (total)                      :: 7,142
            Genes (coding)                    :: 6,967
            CDSs (with protein)               :: 6,967
            Genes (RNA)                       :: 98
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 77
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 175
            CDSs (without protein)            :: 175
            Pseudo Genes (ambiguous residues) :: 0 of 175
            Pseudo Genes (frameshifted)       :: 75 of 175
            Pseudo Genes (incomplete)         :: 141 of 175
            Pseudo Genes (internal stop)      :: 22 of 175
            Pseudo Genes (multiple problems)  :: 59 of 175
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 13:18:17
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6429877
            Orig. end                         :: 6452064
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP060742.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22187
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="23"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22187
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22187
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12187](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12187
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     gene            complement(178..600)
                     /locus_tag="H9W91_RS28685"
                     /old_locus_tag="H9W91_28675"
     CDS             complement(178..600)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357668.1"
                     /locus_tag="H9W91_RS28685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28675"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_232626868.1"
                     /transl_table=11
                     /translation="MTQFIAVVEEFNRFYIRLPRRGNHTFSTLSVLDALAREGSPKRLV
                     DLIASEQLSRPGLTQLVQRLESDGLVERGSDPRDGRAVLVHLTEKGRGVGTSRHRERVA
                     QLTPLIARLTPEERGAITGALPALRRLARLGRDTRG"
     misc_feature    772..787
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 19.62"
                     /tool="antismash"
     gene            776..1780
                     /gene="gap"
                     /locus_tag="H9W91_RS28690"
                     /old_locus_tag="H9W91_28680"
     CDS             776..1780
                     /GO_process="GO:0006094 - gluconeogenesis [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /GO_process="GO:0019682 - glyceraldehyde-3-phosphate
                     metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011559801.1"
                     /locus_tag="H9W91_RS28690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28680"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_076684091.1"
                     /transl_table=11
                     /translation="MTVRVGINGFGRIGRNVFRAVAARNADLEIVAVNDLGDVPTMAHL
                     LTYDSVLGRFPEEVTAEPGAIRVGDREVKVLAERDPAKLPWGDLGVDVVIESTGIFTKA
                     EKARAHIDGGAKKVIIAAPASDEDVTIVLGVNDDIYDPERHTIISNASCTTNCLGVLAK
                     VLHDTVGIEYGMMTTVHAYTQDQNLQDAPHKDLRRARSAAVNVVPTSSGAAKAIGLVLP
                     ELQGRLDAFALRVPVPTGSVTDLTVTTSRRTTVEEINEAYAKAADGAYKGLLSYTEAPI
                     VSSDIVTDPASCVYDAGLTRVMGPQVKVVGWYDNEWGYSNRLIDLALKVGSSL"
     gene            complement(1847..2317)
                     /locus_tag="H9W91_RS28695"
                     /old_locus_tag="H9W91_28685"
     CDS             complement(1847..2317)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019357668.1"
                     /locus_tag="H9W91_RS28695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28685"
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_245001641.1"
                     /transl_table=11
                     /translation="MTTSQTNNPPDHLDVGALITAIENFNRFYIRLPALQTLSFTTLSV
                     LDTLTSRGPTRLTKLARTEQISQPGLTQLVTRLEQDGLVERRPDPTDGRAVLVHITEAG
                     RQVGTSRLEDRIRRLGPLVAQLSPADQRAITKALPALSRLAQLGNEEGEDRP"
     misc_feature    complement(2320..2329)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.58"
                     /tool="antismash"
     gene            2660..3856
                     /gene="penM"
                     /gene_synonym="pntM"
                     /locus_tag="H9W91_RS28700"
                     /old_locus_tag="H9W91_28690"
     CDS             2660..3856
                     /EC_number="1.14.19.8"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016636 - oxidoreductase activity, acting
                     on the CH-CH group of donors, iron-sulfur protein as
                     acceptor [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="penM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000059: Other (85% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="pntM"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182237.1"
                     /locus_tag="H9W91_RS28700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28690"
                     /product="pentalenolactone synthase"
                     /protein_id="WP_076684089.1"
                     /sec_met_domain="p450 (E-value: 3.1e-17, bitscore: 61.2,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELPRLPFDNPSIMGIAPQMRALQREGPIARVRTAGEDAWLVTR
                     YDEVRTLLADPRLRLSNPDPEQSANSAARGFMVALMAGDDCATEPARHAQMRALLVPLF
                     STRRMRRMQTRIERHVDELLDQLAVSAPPVDLHRALSFPLPTMVVCDLLGVPLDDRERF
                     GQYARGTFDHSDDQHSANTFKKVVDYLRELVARKRTEPGDDILSELISAKDGALSDEEI
                     VQLGAAVLLFGYETTIVRIDLGTLLLFRNPAQRAQLVEDPGLAPAAVEEILRLGVGGKG
                     SNALIPRYAHSDITVGDTVIRAGDAVKLAIGAANIDGRAYPDPDVLDLTRDRPRSNLAF
                     GHGARLCIGRTLARIELTAVFERLFRRLPELRLAVPEESLRWQEHRITGGFDEIPVTF"
     misc_feature    2678..2680
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            3951..4811
                     /gene="ptlH"
                     /gene_synonym="penH; pntH"
                     /locus_tag="H9W91_RS28705"
                     /old_locus_tag="H9W91_28695"
     CDS             3951..4811
                     /EC_number="1.14.11.35"
                     /GO_function="GO:0051213 - dioxygenase activity [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlH"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PhyH"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penH; pntH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182238.1"
                     /locus_tag="H9W91_RS28705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28695"
                     /product="1-deoxypentalenic acid 11-beta-hydroxylase"
                     /protein_id="WP_211827548.1"
                     /sec_met_domain="PhyH (E-value: 3.2e-17, bitscore: 62.2,
                     seeds: 39, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDTFSDYADCTPLIDDREALDRFYDEHGYLYLRGVLDRDLVRTA
                     AEQMLEGLIALGHAAPGTTLETLTIESFEAVDEVAMHDYVKYDDLWNHPSTLKVWEKAF
                     GEPVFVFKSTTIRYYPSAAGAAGSEEPHFLTPLHQDGFYIGPNKDFRTAWIPLLPTTPG
                     TGGVALADGSHKKGPREHVVTENFRRFGHLVRGIPAEEFGADERLLFSPMEPGDVLLFH
                     AYMCHKSIPNVSADPAAMRMSMDTRVQPATSHRGFNSLTPWPESAKDASKGILSKITGT
                     PTTIE"
     misc_feature    complement(3993..4007)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 17.3"
                     /tool="antismash"
     gene            4870..6324
                     /locus_tag="H9W91_RS28710"
                     /old_locus_tag="H9W91_28700"
     CDS             4870..6324
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358326.1"
                     /locus_tag="H9W91_RS28710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28700"
                     /product="MFS transporter"
                     /protein_id="WP_076684087.1"
                     /transl_table=11
                     /translation="MTQREGLPSPQGPTAAPEPPAGPRPAATGLSGIALVVVLTGYALS
                     IVDASIVNVALNPISDDLHGGPAALELVVSGYGLTYALGLVLGGRLGDAFGRQRLYAYG
                     LAAFTLTSALCGLAPTIEFLVAARLLQGAAAAMLVPQVLATIQAATEGQARARAIGMYG
                     ATAALGMVIGQILGGLLVSLDIAGIGWRAVFAINVPIGVAALLAVRRVPATKADAKPSF
                     DPRGTALFGLTMVCVLALVVAGPELGWPPWLWSLLLVAAAGAVALARVERGLEARGGSP
                     LLSPSVLSHQGMRRGLAAMVPFSAGFGAFLFVYALVAQGHFGFDGLESGGGLAPFAVAF
                     FAVTLFTPRIAAALGARIVTLGAFVQGAGLLLLALVIRLGWPHPSLTLVLVGIGLYGVG
                     AALTGPTLFRMILADVPPAQAGMGSGVLVTSQQMATALGATVGGTVYLSLADWQSTVSA
                     AVGVLALLACCSVTVLVISLKLPDPR"
     gene            6426..7253
                     /gene="ptlF"
                     /gene_synonym="penF; pntF"
                     /locus_tag="H9W91_RS28715"
                     /old_locus_tag="H9W91_28705"
     CDS             6426..7253
                     /EC_number="1.1.1.340"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: PKS_KR (6-174). E-value: 6e-13. Score:
                     41.0. Matches aSDomain:
                     nrpspksdomains_H9W91_RS28715_PKS_KR.1"
                     /codon_start=1
                     /gene="ptlF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penF; pntF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182240.1"
                     /locus_tag="H9W91_RS28715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28705"
                     /product="1-deoxy-11-beta-hydroxypentalenate dehydrogenase"
                     /protein_id="WP_076684086.1"
                     /sec_met_domain="adh_short (E-value: 1.4e-29, bitscore:
                     102.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHSQTQTAVVTGAASGIGLALSARLARAGASVIMADVEGGALRRR
                     AAELTAQGGQVTAVTADLTDPDAVERLADTAFDVLGDIDVVCNNAGVLGPVGQPLWEAP
                     LERMREVFEVNHWAHVLVARAFVPRLLARGRPAHLVHTASMSAFVVGAGSAAYAASKHA
                     DLAVARSLRADLADTGIRVSVLCPGRVDTPMVQGLTAPRGAGGDTSVSAEAVAGVVVDA
                     LGSDRFYLFSNSDAPQRLRDQFDDVWRHVSLSPPSPEEELWPAPKATTGATKH"
     aSDomain        6444..6947
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H9W91_RS28715_PKS_KR.1"
                     /evalue="6.00E-13"
                     /label="H9W91_RS28715_PKS_KR.1"
                     /locus_tag="H9W91_RS28715"
                     /protein_end="174"
                     /protein_start="6"
                     /score="41.0"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TAVVTGAASGIGLALSARLARAGASVIMADVEGGALRRRAAELTA
                     QGGQVTAVTADLTDPDAVERLADTAFDVLGDIDVVCNNAGVLGPVGQPLWEAPLERMRE
                     VFEVNHWAHVLVARAFVPRLLARGRPAHLVHTASMSAFVVGAGSAAYAASKHADLAVAR
                     SLRAD"
     CDS_motif       6450..6515
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_H9W91_RS28715_0001"
                     /evalue="4.60E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="H9W91_RS28715"
                     /protein_end="30"
                     /protein_start="8"
                     /score="16.1"
                     /tool="antismash"
                     /translation="VVTGAASGIGLALSARLARAGA"
     CDS_motif       6837..6902
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_H9W91_RS28715_0002"
                     /evalue="1.20E-02"
                     /label="PKSI-KR_m4"
                     /locus_tag="H9W91_RS28715"
                     /protein_end="159"
                     /protein_start="137"
                     /score="8.2"
                     /tool="antismash"
                     /translation="HLVHTASMSAFVVGAGSAAYAA"
     gene            7316..9070
                     /gene="ptlE"
                     /gene_synonym="penE; pntE"
                     /locus_tag="H9W91_RS28720"
                     /old_locus_tag="H9W91_28710"
     CDS             7316..9070
                     /EC_number="1.14.13.170"
                     /EC_number="1.14.13.171"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000057: Oxidation (93% identity)"
                     /gene_functions="other (smcogs) SMCOG1092: hypothetical
                     protein"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penE; pntE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182241.1"
                     /locus_tag="H9W91_RS28720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28710"
                     /product="neopentalenolactone/pentalenolactone D synthase"
                     /protein_id="WP_076688792.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 2.7e-07, bitscore:
                     28.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MREKYRQERDKRGAGRTYQFARGDFSHYARDPYTERREREPLTDE
                     VDVAVVGAGIGGLLTGANLRKETGLDRIRLIDEAGDVGGTWYWNRFPGVRCDVESYIYM
                     PLLEETGTIPTEKYSTGPEIFAHLQRIAREYDLYRDALFQTTVTELRWDEAAARWLVST
                     DRGDVIRARYVAMSIGLMHRPKLPGLPGLDAFAGHSFHASRWDFDYTGGDSTGGLTGLR
                     DKRVGVIGTGSTTIQLAPHLAEWAKELVLFQRTPATVDVRGNRPTPPGWAESLEPGWQQ
                     RRMENFHALTSGIPQDEDLVQDRWTQTTAKLAAAILPTGDTGGDPKERALAAERADFLK
                     MEELRARIDSVVTDPATAAALKPYYRVYCKRPCFHDGYLQTFNRPNVTLVDTQGQGVER
                     LTPAGVVANGREYPVDCLIFATGYEHEFAVPYTERAGYDIVGRGGTRLSEKWADGARTL
                     HGLQVNGFPNCFILSKVQAGRHVNIAYMLGEQTRHLAHIVKCVEERGHRVVEASEAGEK
                     EWVEEILRLASSDLDFLENCTPGLYNNEGDPGGLPLLNSSYGGGSVEFVNILRRWREAG
                     DLAGLDLR"
     gene            9105..10004
                     /gene="ptlD"
                     /gene_synonym="penD; pntD"
                     /locus_tag="H9W91_RS28725"
                     /old_locus_tag="H9W91_28715"
     CDS             9105..10004
                     /EC_number="1.14.11.-"
                     /EC_number="1.14.11.36"
                     /GO_function="GO:0016706 - 2-oxoglutarate-dependent
                     dioxygenase activity [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: TauD (4-281). E-value: 2.9e-53. Score:
                     173.3. Matches aSDomain:
                     nrpspksdomains_H9W91_RS28725_TauD.1"
                     /codon_start=1
                     /gene="ptlD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TauD"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000058: Dehydration, Oxidation (86% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1121: dioxygenase, TauD/TfdA"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penD; pntD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014182242.1"
                     /locus_tag="H9W91_RS28725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28715"
                     /product="neopentalenolactone/pentalenolactone F synthase"
                     /protein_id="WP_076684085.1"
                     /sec_met_domain="TauD (E-value: 3.5e-51, bitscore: 173.3,
                     seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDVTPIPGAALGAVVDGAHVSGDMDEAQANEIWAALDAHLVLVFR
                     GHETPTYEEFLAFGRRFGHIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAGWMGW
                     HTDYSFRPRVSQVGFLEAVEVPPSGGGETLFTDMYALYESLPAEERRRLHSYRVRHALR
                     TGYEETIEEELQGEVSLGEDPRRIRAEDGTSTVHPLVARNPRTGRRSVYVSTLNTERIV
                     DLAPDAGRELLDKLLAHAGTPRHTYAHTWRPGDIVMWDQLGTVHAKRAFDPAERRVMRQ
                     VVSIFDDPTAPWRAEAAA"
     aSDomain        9117..9947
                     /aSDomain="TauD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_H9W91_RS28725_TauD.1"
                     /evalue="2.90E-53"
                     /label="H9W91_RS28725_TauD.1"
                     /locus_tag="H9W91_RS28725"
                     /protein_end="281"
                     /protein_start="4"
                     /score="173.3"
                     /tool="antismash"
                     /translation="PIPGAALGAVVDGAHVSGDMDEAQANEIWAALDAHLVLVFRGHET
                     PTYEEFLAFGRRFGHIPKTGLTSGAHPDHNEILIVSNLVEDGRKIGVGDAGWMGWHTDY
                     SFRPRVSQVGFLEAVEVPPSGGGETLFTDMYALYESLPAEERRRLHSYRVRHALRTGYE
                     ETIEEELQGEVSLGEDPRRIRAEDGTSTVHPLVARNPRTGRRSVYVSTLNTERIVDLAP
                     DAGRELLDKLLAHAGTPRHTYAHTWRPGDIVMWDQLGTVHAKRAFDPAERRVMRQ"
     gene            10001..11014
                     /locus_tag="H9W91_RS28730"
                     /old_locus_tag="H9W91_28720"
     CDS             10001..11014
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358322.1"
                     /locus_tag="H9W91_RS28730"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28720"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_076684084.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 6.7e-61, bitscore:
                     204.6, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSTAPACLSHSRVTITPALRAAVDRLDHRSRHQAAYHFGWITAGG
                     APTSADAGKAVRPALALLSAEAVGAPPEVALPGAVAVELVHNFSLVHDDLMDGDEERRH
                     RRTVWKLWGPSSAILTGDAMLALAQEVLLDTGLPTAAPAARLLARTTRHLIRGQVQDLS
                     FEQRGHVTVEECLDMAAGKTGALLSASAAIGAVLAGAPEATVDALALYGDHVGIAFQLV
                     DDVLGIWGDPAVTGKSAHSDLRSRKKTLPVSHALHQDGPLSAELAAWLATRGEPGEEEL
                     RRAAALVEGAGGRDWALAEAARRMALAEAALRGVDLDAGARDELLALGRFVVDREG"
     gene            11177..12187
                     /gene="ptlA"
                     /gene_synonym="penA; pntA"
                     /locus_tag="H9W91_RS28735"
                     /old_locus_tag="H9W91_28725"
     CDS             11177..12187
                     /EC_number="4.2.3.7"
                     /GO_function="GO:0050467 - pentalenene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /gene_synonym="penA; pntA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019358321.1"
                     /locus_tag="H9W91_RS28735"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28725"
                     /product="pentalenene synthase"
                     /protein_id="WP_211827550.1"
                     /sec_met_domain="T1TS (E-value: 1.6e-79, bitscore: 267.0,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQDVDFSIPLPGRRSPDYARAEAAHIEWPRSFGLISSEAAAERH
                     RKGGYADLASRFYPSTTGADLDLGVDLMSWFFLFDDLFDGPRGEDPEQARQLTDAVAAA
                     LDGPLPASAPLIAHGFADVWRRTCQGMSKEWCTRSAQHWRHYFQGYVDEAHGRLDETPC
                     GSAREYLAMRRHTIGVQPTIDLAEATGHFEVPHRVFDGAVMSAMLRIAVDVNLMLNDIA
                     SLEKEEARGELNNMVFILMREHGWTRSRSIAHMQDEVGVRLEEFLLLESILPKVCDAFS
                     LTADEREAVERYRLDAVRPVIRGSYDWHRSSGRYDAEFALAAGRQGFLEELGSAR"
     gene            12238..13608
                     /gene="ptlI"
                     /gene_synonym="penI; pntI"
                     /locus_tag="H9W91_RS28740"
                     /old_locus_tag="H9W91_28730"
     CDS             12238..13608
                     /EC_number="1.14.15.32"
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0050467 - pentalenene synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="ptlI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000060: Oxidation (75% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /gene_synonym="penI; pntI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014133527.1"
                     /locus_tag="H9W91_RS28740"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28730"
                     /product="pentalenene oxygenase"
                     /protein_id="WP_076684082.1"
                     /sec_met_domain="p450 (E-value: 3.7e-77, bitscore: 258.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQQTAQPEQQTFVAGTAPGAAPLVGHAWQMMRRPLQFMSSLSRH
                     GDLVKIRLGPTEAHVPTHPALLRQVLTSDNEYDKGGIFYDRARDIAGNGLVTCPYADHR
                     RQRRLMQSAFTRPQLKRYASAMHAEIETTAERWSDGAVVDAFPEMYGMALRTVGRTLYS
                     TPVSKELADSVERAFDAVLKGLFRQMFLPAAVRRMPSPGNRRYRANLDYLHRTTQTLID
                     DYRRDGADHDDLLSALLDSRDEDGGRLGDKEIHDQVITVMAAGTETVAATLTWIFYLLS
                     KYPRIEKALYAEIDEVLGGRAPEFDDVARLQLTDRIITETLRLYPPAWLFTRLTATDLD
                     VAGLRLPAGSTVVFSPAAVALDAGSFPHERRFDPDRWLPDRVTPQARQSFMAFGTGARK
                     CIGDLYARTEATLALATILSTWRVTCEPGVDVRPVPLATVYQPRRLRLRLTARTPGA"
     gene            complement(13662..14141)
                     /locus_tag="H9W91_RS28745"
                     /old_locus_tag="H9W91_28735"
     CDS             complement(13662..14141)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014045198.1"
                     /locus_tag="H9W91_RS28745"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28735"
                     /product="MarR family winged helix-turn-helix
                     transcriptional regulator"
                     /protein_id="WP_076684081.1"
                     /transl_table=11
                     /translation="MTERRIPSPADPDAADAALVSQPIGYWSGAVHRAVTRRIRDAMAR
                     MDVTQPQWWTLNRVAADPGPTRETVAAQLAEVADGPYEIPRVVDQLLHRGWLLVDPEQR
                     LFVTDEGREAMGRVTGLVTSLRAEVHDGVSDEDYVTTLRVLRTMLGNLDGGKQRA"
     gene            14281..15552
                     /locus_tag="H9W91_RS28750"
                     /old_locus_tag="H9W91_28740"
     CDS             14281..15552
                     /GO_function="GO:0004180 - carboxypeptidase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1244: amidohydrolase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016572954.1"
                     /locus_tag="H9W91_RS28750"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28740"
                     /product="amidohydrolase"
                     /protein_id="WP_211827551.1"
                     /transl_table=11
                     /translation="MSDDPARDRTPAAPAALAGLDALQGDLADLYRHLHAHPEPSFEEH
                     RTAAEAARRAASYGYEVTTGVGRTGVVAVLANGEGPAVLLRADMDALPVTEATGLPYAS
                     RTEGVMHACGHDMHVTCLLGALKLLADSRDAWSGRVVAVFQPAEEAGQGAQVMVADRFY
                     ERFGTPDVVLGQHVAPLPAGMVGAHAGPAFAATDALRVRMFGKGGHGSRPEATVDPVVM
                     AASTVMRLQTVVSREVAGGETAVVTVGVLRAGAKHNVIPDEAELQLNIRTYTPEVRTRV
                     LAAVERIIKGEAATAGAEREPEITEIDTFPVVVNDAHAVDRTMAAVGAVIGAERVMDPG
                     QVTGSEDVGHFATSAEPEVPLCYWLLGGADPAKVIAAQRAGTFERDIPSNHSPFFAPLI
                     EPTITTGVTALTTAALAWLGGPRR"
     gene            complement(15562..19167)
                     /gene="cobN"
                     /locus_tag="H9W91_RS28755"
                     /old_locus_tag="H9W91_28745"
     CDS             complement(15562..19167)
                     /EC_number="6.6.1.2"
                     /GO_function="GO:0051116 - cobaltochelatase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobN"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1263: cobaltochelatase subunit CobN"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008744494.1"
                     /locus_tag="H9W91_RS28755"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28745"
                     /product="cobaltochelatase subunit CobN"
                     /protein_id="WP_076684079.1"
                     /transl_table=11
                     /translation="MLLLLSTSDTDLLSARAAGGPVDYRFANPSRLDLAELPALLDGAD
                     LVVVRLLGGVRAWQDGLDQLTASGLPVVVLTGEQAPDAQLMASSTVPVGIAAEAHAYLA
                     HGGPANLEQLARFLSDTVLLTGHGFEPPAPAPSWGPLERAARDVAGPTVAVLYYRAHHM
                     SGNTAFVDALCGAIEDAGARPLPLYVASLRAPEPELIEELRAADAIVTTVLAAGGTKPA
                     EASAGGDDESWDAGALTGLDVPILQALCLTGSRSAWEENDEGVSPLDAASQIAVPEFDG
                     RLITVPFSFKEIDEDGLPAYVADAERAARVAGIAVRHARLRHIPAADKRLALVLSAYPT
                     KHSRIGNAVGLDTPASAVALLRRLIDEGYDFGPAEEIPGLVSGDGDELIRALIDAGGHD
                     QDWLTDEQLAANPVRIPAAAYKRWYATLPQELRESVEEHWGPPPGEMFLDRSRVADGGD
                     PEGDIVLAALRRGNLLILIQPPRGFGQNPIAIYHDPDLPPSHHYLAAYRWIAASADDGG
                     FGADAMVHLGKHGNLEWLPGKNAGLSAACGPDAALGDLPLVYPFLVNDPGEGTQAKRRV
                     HATLIDHLVPPMDRADSYGDIARLEQLLDEYAQISSMDPAKLPAIRAQIWTLIQAAKLD
                     HDLGLEDRPDDDGFDDFLLHVDGWLCEIKDMQIRDGLHVLGSAPAGAARVNLVLAILRA
                     RQIWGGASALPGLREALGLDESAATRASADEAEEKARALVQAMDDADWDLSAVPADQSE
                     QVRAILEFAAREVVPRLAATTAELDHSVHALNGGFVPAGPSGSPLRGLVNVLPTGRNFY
                     SVDPKAVPSRLAWETGQALADSLIERYRTDNGDYPTSVGLSLWGTSAMRTAGDDVAEAM
                     ALLGVRPVWDDASRRVTGLEAIPYEELGRPRIDVTLRISGFFRDAFPHTIGLLDDAVRL
                     AASLEEPAEQNHVRAHAQADLAEHGDERRATTRIFGSRPGTYGAGLLQLIDSRDWRTDA
                     DLAEVYTVWGGYAYGRGLEGRPARAEMETAYKRIAVAAKNTDTREHDIADSDDYFQYHG
                     GMVATVRALRGTAPEAYIGDSTRPETVRTRTLVEETSRVFRARVVNPKWIEAMRRHGYK
                     GAFELAATVDYLFGYDATTGVVADWMYDKLTETYVLDPTNRQFLQEANPWALHGIAERL
                     LEAESRGMWAKPDPAVLEALRQAYLETEGNLEDEG"
     regulatory      complement(19224..19296)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     gene            19446..20732
                     /gene="cobG"
                     /locus_tag="H9W91_RS28760"
                     /old_locus_tag="H9W91_28750"
     CDS             19446..20732
                     /EC_number="1.14.13.83"
                     /GO_function="GO:0016709 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen, NAD(P)H as one donor, and incorporation
                     of one atom of oxygen [Evidence IEA]"
                     /GO_process="GO:0019250 - aerobic cobalamin biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="cobG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003980411.1"
                     /locus_tag="H9W91_RS28760"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28750"
                     /product="precorrin-3B synthase"
                     /protein_id="WP_211827553.1"
                     /transl_table=11
                     /translation="MLAAMPPTRATSTNKGESLIRDRGDACPGALRPHLADDGALVRLR
                     LPAGLLTGHQAAVLADAAERLADGALSVTSRGNVELRGLADGCVSALAALLTDAGLLPS
                     GRHERIRNIVASPLAGLDGLGRADVQLWARELDGLLCAREWTAALSGRFLFALDDGRGD
                     MAGLGGDVTLIAESDGTAVVRAGDPALRVAAADAPRAALAAAGAFLAAAREAGNGAWRV
                     RELPDGRRVDLAAALEEAGVAATPAEPSTAPRATPHPPGVTGRAVAVSAPLGRVTAAQW
                     RALLPLPADELRVTPWRGFVLPGFADAGAARDRLAALAGAGFLTDPASPWLGVGACTGR
                     PGCAKSLADVRADAVPGLGGLPVHWSGCERRCGHPRGDWVDVLATGDGRYEVTVRTSGG
                     HGTPVRGGTLTEAVSTARTTSATTPTATK"
     gene            20744..21370
                     /locus_tag="H9W91_RS28765"
                     /old_locus_tag="H9W91_28755"
     CDS             20744..21370
                     /EC_number="5.4.99.61"
                     /GO_function="GO:0016993 - precorrin-8X methylmutase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015578014.1"
                     /locus_tag="H9W91_RS28765"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="H9W91_28755"
                     /product="precorrin-8X methylmutase"
                     /protein_id="WP_103557396.1"
                     /transl_table=11
                     /translation="MFDYEKDGAAIYRESFATIRAEADLAGLPADVSQVAVRMIHACGM
                     VDLVRDLAFSPRVIADARKALRDGAPILCDANMVASGVTRKRLPADNEVVCTLADPAVP
                     DLAAQLATTRSAAALELWRDRLEGSVVAIGNAPTALFRLLEMIEAGAPRPAAVLGIPVG
                     FVGAAESKDALAEHSSGLEYLVVRGRRGGSAMAAAAINAIASEAE"
     misc_feature    21728..21743
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.11"
                     /tool="antismash"
ORIGIN
        1 agatcggcga gtcctggcgg catctggaga ccgtcggagt cctgacgggg tgggcgatcg
       61 ccggtctcgt cctcgccccc gtcgtgctgc ggcgcatggc ccggcgggag tccggatcgg
      121 ccgtggccga acgcagggag aaggcgctgc gacgggtcgg ctgacgccgg gccccggtca
      181 gccccgtgtg tcccttccca gccgtgcgag gcgccgcagg gcgggcagtg ccccggtgat
      241 cgcgccgcgc tcctcggggg tgagccgtgc gatgagcggg gtgagctgcg cgacccgttc
      301 ccggtgccgt gacgtgccga cgccgcggcc cttctcggtg aggtggacga ggacggcgcg
      361 gccgtcgcgc gggtcgctcc cgcgttccac gaggccgtcg ctctccaggc gctggacgag
      421 ctgggtgagc cccgggcggc tgagctgttc gctcgcgatc aggtcgacca gccgtttcgg
      481 gctgccctcg cgggcgaggg cgtcgagcac cgacagcgtg ctgaaggtgt ggttaccccg
      541 acgtggcagc cggatataga aacggttgaa ctcctcgacg acggcgatga actgagtcac
      601 attcagatgg ttttcggagg cgcgcacgcc ggggagccta tagcttgcga agtggcgatg
      661 tattgataac ttacacaagt tgcttatggt gtttcgggtg gccggcacgg ctggcgcgtc
      721 ctgcgcggcc accctctccc cgactgtcga gcctcaaacg ctgtgagagg aacgcatgac
      781 tgttcgtgta ggtatcaacg gcttcggccg catcgggagg aacgtcttcc gggcggttgc
      841 cgccaggaac gcggacctgg agatcgtcgc ggtcaacgac ctgggcgacg ttccgaccat
      901 ggcccacctc ctgacctacg attcggttct cggccgtttc cccgaagagg tcaccgccga
      961 gcccggcgcc atccgggtcg gcgaccgcga ggtcaaggtc ctcgccgagc gcgaccccgc
     1021 gaaactcccc tggggcgacc tgggggtgga cgtggtcatc gagtccacgg gcatcttcac
     1081 caaggccgag aaggcccgcg cgcacatcga cggcggcgcc aagaaggtga tcatcgccgc
     1141 ccccgcgagc gacgaggacg tcaccatcgt cctgggtgtc aacgacgaca tctacgaccc
     1201 cgagcgccac acgatcatct ccaacgcctc ctgcaccacc aactgcctgg gcgtcctggc
     1261 caaggtgctg cacgacacgg tcggcatcga gtacgggatg atgaccacgg tccacgccta
     1321 cacccaggac cagaacctcc aggacgcccc gcacaaggac ctgcgccgcg cgcgctcggc
     1381 cgccgtcaac gtggtgccga cgtccagtgg agccgccaag gccatcggcc tcgtcctgcc
     1441 cgaactccag ggccgcctcg acgcattcgc gctgcgggtc cccgtgccga ccggctcggt
     1501 caccgacctg acggtcacca cgagccgccg caccacggtc gaggagatca acgaggcgta
     1561 cgcgaaggcc gccgacggcg cgtacaaggg gctgctctcc tacaccgagg cgcccatcgt
     1621 cagctccgac atcgtcacgg acccggcctc ctgcgtctac gacgccgggc tcacccgcgt
     1681 gatgggcccg caggtcaagg tcgtcggctg gtacgacaac gagtggggct actccaaccg
     1741 cctcatcgac ctcgccctga aggtcggctc ctcgctctga ggcccgtcgt gggcccggtc
     1801 gtcggcgggt ccggctcgcg ccctcgcggg gcgtcgggcc gatccgtcac ggccggtcct
     1861 cgccctcctc gttgccgagt tgagcgaggc gggagagcgc cggcagcgcc ttcgtgatcg
     1921 cccgctggtc cgcgggcgac aactgggcga cgagcgggcc caggcgccgg atgcggtcct
     1981 ccaggcgcga cgtgccgacc tggcggcccg cctccgtgat gtggacgagg acggcgcgtc
     2041 cgtccgtcgg gtcgggacgg cgttccacga gcccgtcctg ttcgagacgc gtgaccagtt
     2101 gggtgaggcc cggctggctg atctgctcgg tcctggccag tttggtgagc cgcgtcgggc
     2161 cgcgggaggt cagggtgtcg agcaccgaaa gcgtcgtgaa cgacagcgtc tgcagcgccg
     2221 gcaggcggat gtagaagcgg ttgaagttct cgatcgccgt gatcagggcg cccacgtcca
     2281 agtggtccgg cgggttgttg gtctgcgaag tggtcaccct agaaaaatag cgcacactta
     2341 tatagtctcg ttgatgcatt cgaggtcggc gcctcgcggc ggtatgcggg ccgttccgga
     2401 cctccatggc gcaatggcgc gtcggcccac gtcagtagcg cagagcgagg aacgcatcca
     2461 tgcccacgcg tatcggcacc gcacggagca cggacctcgg catcgtggcc tccccatgaa
     2521 ccggccccgc ccaagccgcg cgctcccgtc gcggtgaaga cggtgaagag cagacactga
     2581 cgcagaattt cccgccgctg tcgatccggg gcgctttcag aggaatgccg aaaggcctcg
     2641 gggaaatgag catggacacg tgacggaact tccgaggtta cccttcgaca acccgtccat
     2701 catgggcatc gcgccgcaga tgcgggcact gcagcgggaa gggccgatcg ccagggtgcg
     2761 gaccgccggt gaggacgcct ggctggtcac ccggtacgac gaggtcagga cactgctcgc
     2821 cgacccccgc ctccgcctca gcaaccccga ccccgagcag tcggccaaca gcgccgccag
     2881 gggcttcatg gtcgccctga tggccgggga cgactgcgcg accgagcccg cccggcacgc
     2941 ccagatgcgc gccctgctcg tccccttgtt ctccacgcgc cgcatgcgcc ggatgcagac
     3001 ccgcatcgag cgccatgtgg acgaactgct cgaccagttg gccgtgagcg ccccgcccgt
     3061 cgacctgcac cgcgccctgt cgttcccgct gccgaccatg gtggtctgcg acctgctcgg
     3121 cgtgccgctg gacgaccggg agcggttcgg gcagtacgcg agaggcacct tcgaccacag
     3181 cgacgaccag cactcggcga acaccttcaa gaaggtcgtc gactatctga gggaactggt
     3241 ggcccgcaag cggaccgagc cgggcgacga catcctctcc gagctgatct ccgccaagga
     3301 cggcgccctg tccgacgagg agatcgtcca actgggcgcc gccgtcctgc tgttcggcta
     3361 cgagaccacc atcgtccgca tcgacctggg caccctgctg ctgttccgca acccggccca
     3421 gcgcgcgcaa ctcgtcgagg acccgggact cgcgcccgcc gcggtcgagg agatcctgcg
     3481 cctcggcgtc ggcggcaagg gctccaacgc gctgataccc cgctacgccc acagcgacat
     3541 caccgtgggc gacaccgtga tccgggccgg ggacgcggtg aaactggcca tcggcgcggc
     3601 caacatcgac ggccgggcct accccgaccc ggacgtgctc gacctgaccc gggacaggcc
     3661 caggtcgaac ctggccttcg ggcacggcgc ccgcctctgc atcggccgca ccctggcccg
     3721 catcgagctg acggccgtct tcgagcggct gttccgcagg ctgcccgaac tgcggctcgc
     3781 cgtccccgag gagtccctgc gctggcagga gcaccgcatc accggcggct tcgacgagat
     3841 ccccgtgacg ttctgagcgg cgtccgccgg ccgccggcgg cccgccccca gcaggaacct
     3901 ccgcatcgaa ctcctccttc ccccgcgcgg acaccacgag gacaaggatc atgacggaca
     3961 ctttcagcga ctacgccgac tgcacgcccc tcatcgacga ccgtgaggcc ctcgaccggt
     4021 tctacgacga gcacggctac ctctatctgc gcggcgtcct cgaccgcgac ctcgtgcgga
     4081 ccgccgccga gcagatgctc gaaggcctga tcgccctcgg ccacgccgct cccggcacca
     4141 cgctggagac cctcaccatc gaatccttcg aggcggtcga cgaggtggcg atgcacgact
     4201 acgtcaagta cgacgacctg tggaaccacc cctccaccct caaggtctgg gagaaggcct
     4261 tcggcgagcc cgtcttcgtc ttcaagtcga cgacgatccg ctattacccc tccgccgcgg
     4321 gcgccgcggg ctcggaggaa ccgcacttcc tgacgcccct gcaccaggac ggcttctaca
     4381 tagggccgaa caaggacttc cgcaccgcct ggataccgct gctcccgacg acccccggga
     4441 cgggcggcgt cgccctcgcc gacggcagcc acaagaaggg cccgcgcgag cacgtcgtca
     4501 ccgagaactt ccgccgcttc ggccacctcg tacgcggtat ccccgccgag gagttcggcg
     4561 cggacgagcg cctgctgttc tcgcccatgg aaccggggga cgtgctcctc ttccacgcct
     4621 acatgtgcca caagtccatc ccgaacgtct ccgcggaccc ggccgccatg cggatgtcga
     4681 tggacacccg cgtccagccc gccacctcgc accgcgggtt caactccctg acgccctggc
     4741 cggagtccgc gaaggacgcc tccaagggaa tcctgtcgaa gatcaccggt acgcccacca
     4801 ccatcgaatg accttcccac ccccgaacca gtccccaccg tcccccacac acgcccgggt
     4861 aggcagcgca tgacacaacg cgagggtctc ccctctccgc agggacccac cgcggcaccc
     4921 gagcccccgg ccggcccccg gccggccgcc acggggctca gcggcatcgc cctcgtggtg
     4981 gtgctcaccg gatacgccct gtccatcgtg gacgcctcca tcgtcaacgt ggcgctgaac
     5041 ccgatcagtg acgacctcca cggcggcccc gccgcactcg aactggtggt gtccggctac
     5101 ggcctcacct acgccctcgg cctcgtgctc ggcggacgtc tcggtgacgc cttcggccgg
     5161 cagcgcctgt acgcctacgg gctcgcggcg ttcaccctca cctcggcgct ctgcggactc
     5221 gcgccgacca tcgagttcct cgtcgcggcc cggctgctcc aaggcgccgc cgccgccatg
     5281 ctcgtgccgc aggtgctcgc cacgatccag gcggccaccg agggtcaggc gcgcgcccgc
     5341 gccatcggca tgtacggcgc gaccgccgcc ctcggcatgg tcatcggaca gatcctcggc
     5401 gggctcctcg tctcgctgga catcgccggg atcggctggc gggcggtctt cgcgatcaac
     5461 gtgcccatcg gggtggccgc actgctcgcc gtccggcgcg tccccgcgac gaaggccgac
     5521 gcgaagccgt ccttcgaccc ccggggcacc gccctgttcg gcctcaccat ggtctgcgtc
     5581 ctcgccctgg tcgtggcggg ccccgagctg gggtggccgc cgtggctgtg gtcgctgctg
     5641 ctggtcgcgg cggcgggcgc ggtggcgctg gcgcgggtcg agcgcggact cgaggcgcgg
     5701 ggcggctcac cgctgctgtc cccgtcggtg ctctcccacc aggggatgcg caggggcctg
     5761 gcggcgatgg tgccgttctc ggcgggcttc ggcgccttcc tgttcgtcta cgcactcgtc
     5821 gcgcaggggc acttcggctt cgacgggctc gaatccggcg ggggcctcgc gccgttcgcc
     5881 gtggcgttct tcgcggtgac gctgttcacc ccgaggatcg cggcggccct cggcgcccgg
     5941 atcgtcaccc tgggcgcctt cgtccagggc gcgggcctgc tgctgctcgc gctggtgatc
     6001 cggctgggct ggccgcaccc ctccctgacg ctcgtcctcg tggggatcgg cctctacggc
     6061 gtgggcgcgg cgctgaccgg tcccacgctg ttccggatga tcctcgccga cgtaccgccc
     6121 gcgcaggccg gcatgggcag cggtgtgctg gtgaccagcc agcagatggc gaccgcgctc
     6181 ggcgcgaccg tcggcgggac cgtctatctc tccctggccg actggcagtc gacggtgtcg
     6241 gcggccgtgg gcgtcctcgc gctcctcgca tgctgctcgg tgaccgttct cgtgatcagc
     6301 ctgaagctcc ccgacccccg gtgacgcccg cgccccgcga acggcgcgat ccgatccaga
     6361 ccttctcgtg ggcgacggcg cgccgcttcg tcggcgtgcc cgtgcgcaga agcggagaca
     6421 gccacgtgca ctcgcagacc cagacggccg tcgtgaccgg cgcggccagc ggcatcggcc
     6481 tcgccctcag cgcgcgcctc gcacgcgccg gcgccagcgt gatcatggcg gacgtcgagg
     6541 gcggcgcgct gcgccgccgt gccgccgaac tcacggccca gggcggccag gtcaccgcgg
     6601 tgaccgccga cctgaccgac ccggacgccg tcgaacggct cgcggacacc gcgttcgacg
     6661 tgctcggcga catcgacgtg gtgtgcaaca acgcgggcgt cctcggcccc gtgggacagc
     6721 ccctgtggga ggcgccgctg gagcggatgc gggaggtctt cgaggtgaac cactgggcgc
     6781 acgtgctggt ggcgcgcgcc ttcgtgccgc ggctcctcgc ccgcggccgg cccgcccacc
     6841 tggtccacac cgcctcgatg tccgccttcg tcgtcggtgc gggcagtgcc gcctacgccg
     6901 cgtccaaaca cgccgacctc gcggtcgccc gcagcctccg cgccgacctg gcggacaccg
     6961 gcatccgggt gtcggtgctg tgccccggcc gggtcgacac ccccatggtc cagggcctga
     7021 ccgcgccgcg cggcgcgggc ggcgacacct cggtgagcgc cgaggccgtc gccggcgtcg
     7081 tggtggacgc cctcggctcc gaccgcttct acctcttcag caactccgac gcgccgcagc
     7141 ggctgcgcga tcagttcgat gacgtatggc gtcatgtttc cctttcgccc ccttcccccg
     7201 aggaggagct gtggcccgca ccgaaggcga cgaccggagc gacgaagcac tgaccgaaga
     7261 tgcaccgacc gaagaggcgc cgaccgaaga agcaccaccc atcgacctgg cggcgatacg
     7321 ggagaagtac cggcaggaac gcgacaagcg cggcgccggc cgcacctacc agttcgcgcg
     7381 cggcgacttc agccactacg cgcgcgaccc ctacaccgag cggcgggagc gcgaaccgct
     7441 caccgacgag gtggacgtcg ccgtcgtcgg cgccggcatc ggcggcctgc tgaccggcgc
     7501 caacctgcgc aaggagacag gcctcgaccg catccggctg atcgacgagg ccggcgacgt
     7561 gggcggcacc tggtactgga accgcttccc cggcgtccgg tgcgacgtcg agagctacat
     7621 ctacatgccg ctgctcgaag agaccggcac gatacccacc gagaagtact ccacaggacc
     7681 cgagatcttc gcccacctcc agcggatcgc ccgcgagtac gacctctacc gcgacgccct
     7741 cttccagacc accgtcacgg agctgcgctg ggacgaggcc gccgcgaggt ggctggtgag
     7801 caccgaccgg ggcgatgtga tccgcgcccg ctacgtggcc atgtcgatcg gcctgatgca
     7861 ccgccccaaa ctccccggac tgccgggcct cgacgcgttc gccgggcact ccttccacgc
     7921 cagccgctgg gacttcgact acaccggcgg cgacagcacc ggcggcctga ccgggctgag
     7981 ggacaagcgg gtcggcgtca tcggcaccgg ctcgacgacc atccagctcg ccccgcacct
     8041 cgccgagtgg gccaaggaac tcgtcctctt ccagcgcacc cccgccacgg tcgacgtccg
     8101 cggcaaccgg cccaccccgc ccggctgggc ggagagcctg gaaccgggct ggcagcagcg
     8161 ccgcatggag aacttccacg cactgacctc cggcatcccg caggacgagg acctggtcca
     8221 ggaccgctgg acccagacca cggccaagct cgccgccgcg atcctgccca ccggcgacac
     8281 cgggggagac ccgaaagagc gggcgctcgc ggccgagcgg gcggacttcc tcaagatgga
     8341 ggagctgcgg gcccgcatcg acagcgtcgt caccgacccc gcgaccgccg ccgccctcaa
     8401 gccgtactac cgcgtgtact gcaagcggcc ctgcttccac gacggctacc tccagacctt
     8461 caaccggccc aacgtgaccc tcgtcgacac ccaggggcag ggcgtggaac ggctcacccc
     8521 cgccggggtg gtcgccaacg gccgcgagta cccggtcgac tgcctgatct tcgccaccgg
     8581 ctacgagcac gagttcgccg tcccgtacac cgagcgcgcc ggctacgaca tcgtcggccg
     8641 cggcggcacg cggctgtcgg agaagtgggc ggacggggcg cgcaccctgc acgggctcca
     8701 ggtgaacggc ttccccaact gcttcatcct gtccaaggtc caggcgggga ggcacgtcaa
     8761 catcgcctac atgctgggcg agcagacccg gcacctcgcg cacatcgtca agtgcgtcga
     8821 ggagcgcggc caccgggtcg tcgaggcctc cgaggccggc gagaaggagt gggtggagga
     8881 gatcctccgc ctcgccagca gcgacctgga cttcctggag aactgcacgc ccggcctcta
     8941 caacaacgag ggcgacccgg gcggactgcc gctgctcaac tccagctacg gcggcggctc
     9001 cgtggagttc gtgaacatcc tccgacgctg gcgcgaggcg ggcgacctcg ccggactcga
     9061 cctgcgctga ccatcccacc cctctgcgaa aggcggcaag gaccatggac gtcacgccga
     9121 tacccggcgc cgctctcggc gccgtcgtgg acggcgccca tgtctcgggc gacatggacg
     9181 aggcacaggc gaacgagatc tgggcggcgc tcgacgcgca cctcgtcctg gtcttccgcg
     9241 gccacgagac cccgacctac gaggagttcc tggccttcgg ccgccgcttc gggcatatcc
     9301 cgaagaccgg cctgaccagc ggcgcccacc ccgaccacaa tgagatcctg atcgtctcca
     9361 acctggtgga ggacggccgc aagatcggcg tcggcgacgc cgggtggatg ggctggcaca
     9421 ccgactactc cttccgcccc cgcgtctccc aggtcggctt cctcgaagcc gtcgaagtgc
     9481 cgccctccgg cggcggcgag accctcttca ccgacatgta cgccctgtac gagtccctgc
     9541 ccgccgagga gcgccggcgt ctgcactcct accgggtccg ccacgccctg cgcaccggct
     9601 acgaggagac catcgaggag gaactccagg gcgaggtgtc cctcggcgag gacccccgtc
     9661 ggatcagggc cgaggacggc acctccaccg tccacccgct ggtcgcccgc aacccgcgca
     9721 ccggccgccg ctcggtctac gtcagcaccc tgaacaccga gcggatcgtg gacctcgccc
     9781 ccgacgccgg ccgcgaactg ctcgacaagc tcctcgcgca cgcgggcacc ccccggcaca
     9841 cctacgccca cacctggcgg cccggggaca tcgtcatgtg ggaccagctc ggcaccgtcc
     9901 acgccaagcg ggccttcgac ccggccgaac ggcgcgtcat gcgccaggtc gtcagcatct
     9961 tcgacgaccc gaccgccccc tggcgagcgg aggccgccgc atgagcaccg ctcccgcctg
    10021 cctcagccac agccgcgtca cgatcacccc ggcgctgcgc gccgccgtcg accggctcga
    10081 ccaccgctca cgccaccagg cggcctacca cttcgggtgg atcaccgccg gcggcgcgcc
    10141 caccagcgcc gacgcgggca aggccgtacg cccggcgctc gccctgctct ccgcggaggc
    10201 ggtcggcgcg ccgccggagg tcgccctgcc cggcgccgtc gccgtggagc tggtgcacaa
    10261 cttctccctg gtgcacgacg acctgatgga cggcgacgag gagcgccgcc accggcgcac
    10321 ggtgtggaag ctgtggggcc cctccagcgc catcctgacc ggcgacgcga tgctcgccct
    10381 cgcccaggag gtgctgctcg acaccgggct gccgacggcg gcgcccgccg cccggctgct
    10441 cgcgcgcacc acccggcacc tgatccgcgg ccaggtccag gacctgtcct tcgaacagcg
    10501 cggccacgtc acggtcgagg agtgcctcga catggccgcg ggcaagaccg gcgccctgct
    10561 gtcggcgagc gcggcgatcg gcgccgtcct cgccggggcg cccgaggcga cggtggacgc
    10621 cctcgcgctc tacggcgacc acgtcggcat cgccttccag ctcgtcgacg acgtactcgg
    10681 gatctggggg gaccccgccg tcaccggcaa gtcggcccac tccgacctgc gctcccgcaa
    10741 gaagaccctg ccggtgagcc acgccctgca ccaggacggc ccgctcagcg ccgaactcgc
    10801 cgcctggctc gccacccgcg gcgaacccgg cgaggaggaa ctgcgccggg cggccgccct
    10861 ggtcgagggc gccggcggcc gtgactgggc gctggccgag gccgcccggc gcatggccct
    10921 ggccgaggcc gcgctgcgcg gcgtcgacct ggacgccgga gcacgggacg aactcctcgc
    10981 gctcggccgt ttcgtcgtcg accgcgaggg ctgagcccgg acctgccccc gtagccgcgt
    11041 gtccccgcgt gcaccgcctc cgcccacccc acgtccgcgt acgccgcgca ccgcgggcag
    11101 cgtcgccccg gtgcgtgccc ccacccccgt tcgggcgccc gctcgcgccc tgttccactg
    11161 cccagggagt ctccccatgc cccaggacgt cgacttctcc atccccctgc ccggccgccg
    11221 cagccccgac tacgcgcggg ccgaggccgc acacatcgag tggccccgct ccttcggcct
    11281 catcagcagc gaggccgccg ccgaacgcca ccgcaagggc ggctacgccg acctcgcctc
    11341 ccgcttctac ccctccacca ccggcgccga cctcgacctc ggcgtcgacc tgatgtcctg
    11401 gttcttcctc ttcgacgacc tcttcgacgg tccgcgcggc gaggaccccg agcaggcgag
    11461 gcagctcacc gacgccgtcg ccgccgcgct cgacggaccg ctgcccgcct ccgcgcccct
    11521 catcgcgcac ggcttcgccg acgtctggcg gcgcacctgc caggggatgt cgaaggagtg
    11581 gtgcacccgc agcgcccagc actggcgcca ctacttccag ggctacgtcg acgaggcgca
    11641 cggccgcctc gacgagacgc cctgcggttc cgcccgggag tacctcgcca tgcgccgcca
    11701 cacgataggc gtgcagccca ccatcgacct cgccgaggcc accgggcact tcgaggtgcc
    11761 gcaccgcgtc ttcgacgggg ccgtcatgtc ggcgatgctg cggatcgccg tcgacgtcaa
    11821 cctcatgctc aacgacatcg cctccctgga gaaggaggag gcgcgcggtg agctgaacaa
    11881 catggtgttc atcctgatgc gcgagcacgg ctggaccagg agccgcagca tcgcgcacat
    11941 gcaggacgag gtcggcgtac gcctggagga gttcctgctc ctggagagca tcctgcccaa
    12001 ggtctgcgac gccttctccc tcaccgccga cgagcgcgag gccgtcgaac gctaccgcct
    12061 ggacgcggtg cgccccgtca tccgcggctc gtacgactgg caccgctcat ccgggcgcta
    12121 cgacgccgag ttcgcgctgg ccgccggccg ccaggggttc ctcgaagagc tcggcagcgc
    12181 ccgctgacgg acccgccacc ccgcaccgaa cccgccgagg gaaaccgagg agaacccatg
    12241 gcccagcaga ccgcccagcc cgagcagcag accttcgtcg cgggcacggc gcccggggcg
    12301 gcgcccctcg tcgggcacgc ctggcagatg atgcgccgcc cgctgcagtt catgtcgtcg
    12361 ctgtcccgcc acggcgacct ggtgaagata cgcctgggcc ccaccgaggc ccatgtgccg
    12421 acccatccgg ccctgctccg ccaggtcctg accagcgaca acgagtacga caagggcggc
    12481 atcttctacg acagggcccg tgacatcgcg ggcaacggcc tggtcacctg cccctacgcc
    12541 gaccaccgcc ggcagagaag gctgatgcag tcggcgttca cccgccccca gctcaagcgg
    12601 tacgcgtccg cgatgcacgc cgagatcgag accaccgccg agcgctggag cgacggcgcg
    12661 gtggtcgacg cctttcccga gatgtacggc atggccctgc gcaccgtggg ccgcacgctg
    12721 tactcgacgc cggtcagcaa ggagctggcc gacagcgtgg agcgcgcctt cgacgccgtg
    12781 ctcaagggac tgttccggca gatgttcctg cccgcggcgg tgcgcaggat gcccagtccg
    12841 ggcaaccggc gctaccgcgc caacctggac tacctgcacc gcaccaccca gacgctgatc
    12901 gacgactacc gccgcgacgg cgccgaccac gacgacctgc tctccgccct cctcgactcg
    12961 cgcgacgagg acggcggcag gctcggcgac aaggagatcc acgaccaggt catcaccgtg
    13021 atggcggccg gcacggagac cgtcgccgcc accctcacct ggatcttcta cctgctctcc
    13081 aagtacccgc ggatcgagaa ggcgctgtac gcggagatcg acgaggtcct gggcggcaga
    13141 gccccggagt tcgacgacgt ggcccggctc cagctcaccg accgcatcat caccgagacc
    13201 ctgcggctct acccgccggc ctggctcttc acccggctga ccgccaccga cctcgacgtg
    13261 gcggggctgc ggctgcccgc cggttccacc gtggtgttca gcccggcggc cgtggccctc
    13321 gacgccggat ccttccccca cgagcggcgg ttcgaccccg accgctggct gcccgaccgg
    13381 gtgacaccgc aggcccggca gtccttcatg gccttcggca ccggcgcccg caagtgcatc
    13441 ggcgacctct acgcccgcac cgaggccacc ctcgcgctcg ccaccatcct cagcacctgg
    13501 cgggtcacct gcgaaccggg cgtcgacgtg cgccccgtcc cgctggccac cgtctaccag
    13561 ccacgccggc tgcgcctgcg gctgacggcc cgtacgcccg gggcgtagcg agcggggcgg
    13621 cgggacgggg ccgtcccgcc gccccgccac ggcgatccgg ctcaggcccg ctgcttcccg
    13681 ccgtccagat tgccgagcat cgtgcgcagc accctgagcg tggtcacgta gtcctcatcg
    13741 ctgacgccgt cgtgcacctc cgcccgcagc gacgtgacga gtccggtgac gcgccccatc
    13801 gcctcacggc cctcgtccgt cacgaacagc cgctgctcgg ggtccaccag gagccagccg
    13861 cggtgcagga gttggtcgac gacgcgcggg atctcgtacg ggccgtccgc gacctccgcg
    13921 agctgggcgg cgaccgtctc gcgtgtgggt ccgggatcgg cggcgacgcg gttgagcgtc
    13981 caccactgcg gctgcgtcac gtccatgcgg gccatcgcgt cccggatgcg ccgggtgacg
    14041 gccctgtgca ccgcgccgct ccagtacccg atgggctgcg agacgagggc ggcgtccgcc
    14101 gcgtccgggt cggcggggga ggggatccta cgctcggtca tgggcttcct tcctggggcg
    14161 cgcccggcgg ggccgtggcc ccaccctagc cactgaccgg cccaccgagt ggtgcgtaca
    14221 tccaaggccc gttcgtccgt acagtggccc gcaccgcagc gagacaacga ggagcgcgcc
    14281 atgtccgacg accccgcccg cgaccgcacc cccgcggccc ccgccgccct tgccggactc
    14341 gacgccctcc agggcgacct cgccgacctc taccgccacc tgcacgccca ccccgagccg
    14401 tccttcgagg agcaccgcac cgccgcggag gccgcccgcc gcgccgcctc gtacgggtac
    14461 gaggtcacca ccggcgtggg ccgtaccggt gtcgtggccg tgctggcgaa cggcgagggc
    14521 ccggccgtgc tgctccgcgc cgacatggac gcgctcccgg tgaccgaggc caccggcctg
    14581 ccgtacgcct cccgcaccga gggcgtcatg cacgcctgcg gccacgacat gcacgtcacc
    14641 tgtctgctcg gcgcgctgaa gctgctcgcg gactcccgcg acgcctggtc ggggcgggtc
    14701 gtcgccgtgt tccagcccgc cgaggaggcg gggcagggcg cccaggtgat ggtcgccgac
    14761 cggttctacg agcggttcgg cacgcccgac gtcgtcctcg gccagcatgt cgccccgctg
    14821 cccgcgggca tggtcggcgc gcacgcgggt cccgccttcg cggcgaccga cgccctgcgg
    14881 gtgcggatgt tcggcaaggg cggccacggc tcgcgcccgg aggcgaccgt cgacccggtg
    14941 gtgatggccg cgtccaccgt gatgcggctc cagacggtgg tgtcccgcga ggtggcgggc
    15001 ggtgagaccg ccgtcgtcac cgtcggcgtg ctgcgggcgg gcgccaagca caacgtcatc
    15061 cccgacgagg ccgaactcca gctcaacatc cgcacctaca cgcccgaggt ccgcacccgc
    15121 gtcctcgccg ccgtcgagcg gatcatcaag ggcgaggcgg ccacggccgg cgcggagcgg
    15181 gagcccgaga tcacggagat cgacaccttc cccgtcgtcg tcaacgacgc gcacgccgtc
    15241 gacaggacga tggcggcggt cggcgcggtc atcggcgcgg agcgggtcat ggaccccggc
    15301 caggtgaccg gcagcgagga cgtcggacac ttcgccacct cggcggagcc cgaagtcccg
    15361 ctctgctact ggctgctggg cggcgccgac cccgcgaagg tgatcgccgc gcagcgggcg
    15421 ggcaccttcg agcgggacat cccctccaac cactcgccgt tcttcgcccc gctgatcgaa
    15481 ccgacgatca ccacgggcgt cacggccctg acgacggccg ccctcgcctg gctgggcggc
    15541 ccccgtcggt gacggcgggg ctcagccctc gtcctccagg ttcccctcgg tctccaggta
    15601 ggcctgccgc agcgcttcga gcaccgccgg gtccggcttg gcccacatgc cgcgcgactc
    15661 cgcctccagg aggcgttcgg cgatgccgtg cagcgcccag gggttggcct cctggaggaa
    15721 ctgccggttg gtggggtcga ggacgtacgt ctcggtgagc ttgtcgtaca tccagtcggc
    15781 cacgaccccc gtcgtggcgt cgtagccgaa caggtagtcc accgtcgcgg cgagctcgaa
    15841 ggcgcccttg tagccgtggc ggcgcatcgc ctcgatccac ttcgggttga ccacgcgggc
    15901 gcggaacacc cgtgaggtct cctccaccag cgtgcgcgtg cggaccgtct cggggcgcgt
    15961 ggagtccccg atgtacgcct cgggagccgt gccccgcagc gcgcgcacgg tcgcgaccat
    16021 gccgccgtgg tactggaagt agtcgtccga gtcggcgatg tcgtgctcgc gcgtgtcggt
    16081 gttcttcgcg gccaccgcga tgcgcttgta cgcggtctcc atctcggcgc gcgccgggcg
    16141 gccttcgagc ccgcggccgt aggcgtagcc gccccacacc gtgtacacct cggcgaggtc
    16201 cgcgtccgtg cgccagtcgc gggagtcgat gagttggagc agccccgcgc cgtaggtgcc
    16261 ggggcgcgag ccgaagatgc gggtggtggc ccggcgctcg tccccgtgct cggccaggtc
    16321 ggcctgggcg tgggcgcgca cgtggttctg ctcggcgggc tcctccaggg acgcggcgag
    16381 ccgcaccgcg tcgtcgagca ggccgatcgt gtgcgggaac gcgtcgcgga agaagcccga
    16441 gatgcgcagc gtcacgtcga tgcggggccg gcccagttcc tcgtacggga tggcttcgag
    16501 gccggtgacg cggcgtgagg cgtcgtccca gaccgggcgg acgccgagca gcgccatggc
    16561 ctcggcgacg tcgtcgcccg ccgtgcgcat ggcactcgtg ccccacaggg acaggcccac
    16621 ggaggtgggg tagtcgccgt tgtccgtgcg gtagcgctcg atgagggagt cggcgagggc
    16681 ctggcccgtc tcccacgcga ggcgggacgg gacggccttc gggtcgaccg agtagaagtt
    16741 gcggccggtc ggcaggacgt tgaccaggcc gcgcagcggg gagccggagg ggccggccgg
    16801 gacgaagccg ccgttcaggg cgtgcacgga gtggtccagc tcggcggtgg tggccgccag
    16861 gcgcggcacg acctcgcggg ccgcgaactc caggatggcc ctgacctgct cactctggtc
    16921 ggcggggacg gcggagaggt cccagtcggc gtcgtccatc gcctggacga gcgcacgggc
    16981 cttctcctcg gcctcgtccg cgctcgcgcg cgtcgccgcc gactcgtcga gacccagcgc
    17041 ctcgcgcaga cccggcaggg cggaggcgcc gccccagatc tggcgggcgc gcaggatcgc
    17101 gaggacgagg ttgacgcggg cggcgcccgc cggggcggag ccgaggacgt gcagaccgtc
    17161 gcggatctgc atgtccttga tctcgcagag ccagccgtcg acgtgcagca ggaagtcgtc
    17221 gaagccgtcg tcgtccgggc ggtcctccag gcccaggtcg tggtcgagct tcgcggcctg
    17281 gatgagcgtc cagatctgcg cgcggatcgc gggcagcttc gccgggtcca tggagctgat
    17341 ctgcgcgtac tcgtcgagca gctgctccag gcgcgcgatg tcgccgtagg agtcggcgcg
    17401 gtccatcggc ggcaccaggt ggtcgatgag cgtggcgtgc acgcgccgct tggcctgggt
    17461 gccctcgccc gggtcgttga ccaggaaggg gtagacgagg gggaggtcgc cgagcgcggc
    17521 gtcggggccg caggccgcgg agaggcccgc gttcttgccc ggcagccact ccaggttgcc
    17581 gtgcttgccg aggtggacca tcgcgtcggc gccgaagccg ccgtcgtcgg cggacgcggc
    17641 gatccagcgg taggccgcca ggtagtggtg cgagggcggc agatccgggt cgtggtagat
    17701 cgcgatcggg ttctggccga agccgcgcgg cggctggatg aggatcagca ggttcccgcg
    17761 gcgcagggcg gcgagcacga tgtcgccctc ggggtcgccg ccgtccgcca cgcgggagcg
    17821 gtccaggaac atctcgccgg gcggcggccc ccagtgctcc tccacggact cccgcagctc
    17881 ctgcggcagc gtcgcgtacc agcgcttgta ggcggcggcc gggatgcgga cggggttggc
    17941 ggcgagctgc tcgtcggtga gccagtcctg gtcgtggccg cccgcgtcga tcagcgcccg
    18001 gatcagctcg tcgccgtcgc cggagaccag gccggggatc tcctcggcgg gcccgaagtc
    18061 gtagccctcg tcgatgagcc tgcggagcag cgcgacggcg gacgcggggg tgtcgaggcc
    18121 caccgcgttg ccgatccgcg agtgcttggt cgggtacgcg gacaggacca gggccaggcg
    18181 cttgtcggcg gccgggatgt gccgcagccg cgcgtggcgt acggcgatgc cggcgacgcg
    18241 ggcggcgcgc tcggcgtccg cgacgtacgc cgggagcccg tcctcgtcga tctccttgaa
    18301 cgagaacggc acggtgatga gccgcccgtc gaactccggc accgcgatct ggctggcggc
    18361 gtcgagcggc gagacgccct cgtcgttctc ctcccaggcc gagcgcgacc cggtcaggca
    18421 gagcgcctgg aggatcggca cgtcgaggcc ggtcagcgcg cccgcgtccc acgactcgtc
    18481 gtcaccgccc gcggaggcct cggcgggctt ggtgccgccc gccgcgagga ccgtcgtcac
    18541 gatggcgtcc gccgcgcgca gctcctcgat cagctccggc tccggggcgc gcagcgaggc
    18601 cacgtacagc ggcagcgggc gggcgcccgc gtcctcgatc gcgccgcaca gggcgtccac
    18661 gaacgcggtg ttgccgctca tgtggtgggc gcggtagtag agcaccgcca cggtcgggcc
    18721 cgcgacgtcg cgcgcggcgc gctccagggg gccccaggac ggcgcgggcg ccggcggctc
    18781 gaagccgtgg ccggtgagca gcaccgtgtc ggagaggaag cgggccagct gctccaggtt
    18841 ggcggggccg ccgtgcgcca ggtaggcgtg cgcctcggcg gcgatgccga ccggcacggt
    18901 ggaggaggcc atgagctggg cgtcgggcgc ctgctcgccg gtgagcacga ccaccggcag
    18961 accgctggcg gtgagctggt cgaggccgtc ctgccaggcg cggacaccgc cgaggaggcg
    19021 tacgacgacc aggtcggcgc cgtcgagcag ggcgggcagc tcggcgaggt cgaggcggga
    19081 ggggttggcg aaccggtagt cgacgggacc ccccgccgcg cgggcgctga gcaggtcggt
    19141 gtcggaggtc gacagcagca gaagcatgcg ggcgcaggcc ttcctcgggg tgtccgcgcc
    19201 ccgggtggtc gtatggacgg caggagttcc tggctcaccc cacctggatg gggctcacag
    19261 tggcgggacc gcgccggaat cgcaccgggc ttcctccctc gggcccctgt cgggcccacg
    19321 ccgtcgctgg cgtcggcgga cctggcggcc cgccgactgc atagtaagtc ctgcccgccc
    19381 cgaagtgggc ggccacctgt ccccgcggtc cacttcggga ggcgaccgcg cccgggcgcg
    19441 tgggtatgct cgccgccatg ccgcccaccc gagcaacctc cacgaacaag ggcgaatccc
    19501 tcatacgtga ccggggcgac gcctgtcccg gagccctgcg accgcatctc gccgacgacg
    19561 gcgcgctggt ccgactccgg ctgcccgcag ggctcttgac ggggcatcag gcagcggtcc
    19621 tggccgacgc ggcggaacgg ctcgccgacg gcgccctcag cgtcacctcg cgcggcaacg
    19681 tcgagctgcg cggcctcgcc gacggctgcg tctccgccct ggccgcgctc ctcacggacg
    19741 ccggactgct gccctccggg cgccatgaac gcatacggaa catcgtggcg tccccgctcg
    19801 ccggactcga cggactcggc cgcgccgacg tccagttgtg ggcccgtgag ctggacggac
    19861 tcctctgcgc gcgggagtgg acggccgcgc tgtccgggcg cttcctgttc gccctcgacg
    19921 acgggcgcgg ggacatggcc ggtctcggcg gcgatgtgac cttgatcgca gaatcggacg
    19981 ggacggcggt ggtgcgcgcc ggggaccccg ccctgcgcgt ggccgccgcg gacgccccgc
    20041 gagccgccct cgccgcggcc ggggcgttcc tcgcggcggc ccgcgaggcg ggcaacgggg
    20101 cctggcgggt gcgggagctg cccgacgggc ggcgcgtcga cctggccgcg gcgctggaag
    20161 aggccggtgt cgcggccacg cccgccgagc cgtcgaccgc gccccgcgcc accccgcacc
    20221 cccccggcgt gaccggccgc gcggtcgccg tcagcgcccc cctcggccgc gtcaccgccg
    20281 cccagtggcg ggccctgctc ccgctgcccg ccgacgagct gcgggtcacc ccgtggcgcg
    20341 gcttcgtgct tcccggcttc gccgacgcgg gcgcggcgcg ggaccgcctc gccgcgctgg
    20401 ccggcgccgg gttcctcacc gaccccgcgt cgccctggct cggcgtcggc gcctgcacgg
    20461 gacggcccgg ctgcgccaag tccctcgccg acgtccgcgc ggacgccgtg cccggcctcg
    20521 gcgggctgcc cgtgcactgg tccggctgcg agcggcgctg tgggcacccg cgcggcgact
    20581 gggtcgacgt cctcgccacc ggtgacgggc ggtacgaggt gacggtgcgc acctccggcg
    20641 ggcacgggac acccgtgcgg ggcggcaccc tcaccgaggc ggtcagcacg gcacgtacga
    20701 cttcggcaac cacaccaacg gccacgaaat gagcgagagc acagtgttcg actacgagaa
    20761 ggacggcgcg gcgatctacc gcgagtcctt tgccaccatc cgcgcggagg cggacctcgc
    20821 ggggctgccc gccgacgtca gccaggtcgc ggtccggatg atccacgcct gcggcatggt
    20881 cgacctcgtc cgcgacctcg ccttcagccc gcgcgtgatc gccgacgccc gtaaggcgct
    20941 gcgcgacggc gccccgatcc tgtgcgacgc gaacatggtc gcgagcggcg tcacgcgcaa
    21001 gcggctgccc gccgacaacg aggtggtctg caccctcgcc gacccggcgg tgccggacct
    21061 cgccgcccag ctcgccacca cccgcagcgc cgccgccctg gaactctggc gcgaccgcct
    21121 cgaaggctcc gtcgtcgcca tcggcaacgc gcccaccgcc ctcttccgcc tcctggagat
    21181 gatcgaggcg ggcgcgcccc gcccggccgc cgtgctcggc ataccggtcg gcttcgtcgg
    21241 cgccgccgag tccaaggacg cgctcgccga gcactcctcg ggcctggaat acctggtcgt
    21301 acgggggcgt cgcggcggca gcgcgatggc cgcggcggcg atcaacgcga ttgcgagcga
    21361 ggcggagtga acaccgagac cacgcagggg accaccgctc agggggccct cgggatcgcg
    21421 ccggggaagc tgtacggggt cgggctcggc cccggcgatc cctccctgat gaccgtgcgg
    21481 gccgtcgagg tcatcgccgc cgccgacgtc gtcgcgtacc actccgctcg gcacggccgt
    21541 tccatcgccc gctccatcgc ggcgaagcac ctgcgggacg accacatcga ggagccgctg
    21601 gtctaccccg tcaccacgga gaccaccgac caccccggcg gctaccgcgg cgccctcgac
    21661 gagttctacg aggaggccgc gggccgcctc gccgcgcatc tggacgccgg gcgcacggtc
    21721 gccgtcctcg ccgagggcga cccgctcttc tacggctcct accagcacat gcacaagcgc
    21781 ctcgcccacc gctacgacac cgaggtcatc cccggcgtca cctcggtcag cgcggcggcg
    21841 gcccggctcg gcgaacccct cgtcgaagcc gaggaggtcc tcacggtcct gcccggcacc
    21901 ctccccgagg aggaactggc ggcgcgcctc gcggcgacgg actcggcggt cgtgatgaag
    21961 ctcggccgca ccttcggcaa ggtgcgcgac gccctggagc gcgcgggccg cctggacgag
    22021 gcccgttacg tggagcgcgc caccatggag ggcgagcgca cgggacgcct cgccgaggtg
    22081 gacccggagt cggtgccgta cttctccgtg gccgtgctcc ccagccgcgt ggccccgctc
    22141 accggcggcc ccgcgccgga gccggccccc gagacccgcg gcgaggt
//
