LOCUS       NZ_CP058561            21625 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Vallitalea guaymasensis strain Ra1766G1 chromosome, complete genome.
ACCESSION   NZ_CP058561
VERSION     NZ_CP058561.1
KEYWORDS    RefSeq.
SOURCE      Vallitalea guaymasensis
  ORGANISM  Vallitalea guaymasensis
            Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
            Vallitaleaceae; Vallitalea.
REFERENCE   1  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Vallitalea guaymasensis genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2020) Microbiologie Environnementale et
            Biotechnologie (MEB), Mediterranean Institute of Oceanography (MIO),
            UMR 7294, 163 avenue de Luminy, Marseille 13288, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. JUNE-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141425.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:20:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,859
            CDSs (total)                      :: 4,781
            Genes (coding)                    :: 4,757
            CDSs (with protein)               :: 4,757
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 7 of 24
            Pseudo Genes (incomplete)         :: 16 of 24
            Pseudo Genes (internal stop)      :: 1 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4792539
            Orig. end                         :: 4814164
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058561.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21625
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="14"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21625
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21625
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11625](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11625
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(162..174)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     gene            complement(619..1311)
                     /locus_tag="HYG85_RS20640"
                     /old_locus_tag="HYG85_20555"
     CDS             complement(619..1311)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HYG85_RS20640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20555"
                     /product="metal ABC transporter ATP-binding protein"
                     /protein_id="WP_212691257.1"
                     /transl_table=11
                     /translation="MALLEIKNLSVHYNNYLALDNINLEVNKNDYIGIIGPNGSGKTTL
                     LKSIIGDITPDKGKIMIDPNVIIGYVPQFSTFNRDFPITVFDVILSGTLPSDYKLFYRY
                     KQNDRNKVIFAIDKLKINYLANKRINQLSGGQLQKVLLARALVTNPDILLLDEPTASLD
                     TDAKEEIYNILTTLNKEMTIIMVSHDIGMIKHNVKKFACLNKTMHVHDNDETIDPWHFQ
                     NLFYTKGK"
     gene            complement(1325..2227)
                     /locus_tag="HYG85_RS20645"
                     /old_locus_tag="HYG85_20560"
     CDS             complement(1325..2227)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1252: cation ABC
                     transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013465.5"
                     /locus_tag="HYG85_RS20645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20560"
                     /product="metal ABC transporter solute-binding protein,
                     Zn/Mn family"
                     /protein_id="WP_212691258.1"
                     /transl_table=11
                     /translation="MKRRLLLLASIVLILSGCSGKSVDNNKINIGVSIGPEEAFVNAVL
                     GDKGTVTTVIPSGFSPANYQPSPKELEHISDADLYFTIGVAAENNILPKVVSNKTEVIS
                     LKDASEKQYPILYLDNHSHEHEHEETTEHEEEETSKVIDPHIWMSPKRVIVMINTIRDS
                     LSDIDPENKDYYDDNAAKYIAELEELDIYIEETLKNSNIDNFIIYHPSLGYFANDYGLN
                     MMVIEEDGKTATIETMTNVINFAKEHDIKVVFYQQEFDSKQATVIADEINGKVISLDIL
                     SKEYIDNYKKIVDTFVSSY"
     gene            2404..2838
                     /locus_tag="HYG85_RS20650"
                     /old_locus_tag="HYG85_20565"
     CDS             2404..2838
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1266: hydrogen
                     peroxide sensitive repressor"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF013629.5"
                     /locus_tag="HYG85_RS20650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20565"
                     /product="Fur family transcriptional regulator"
                     /protein_id="WP_212691259.1"
                     /transl_table=11
                     /translation="MDFNKVIDLLKNSGYKLTNQRKIIIEALYHSDKPISMEEWLLLTK
                     DKNPGINLSTIYRNIDVLEDLGLLEKIRPKDDSIKYTLNLMENHSHFLICKRCGKAEAI
                     ECCLSKEFKKVIEDKEFDLIEHNLELYGYCKECHNELDKK"
     gene            complement(2881..3987)
                     /gene="aroC"
                     /locus_tag="HYG85_RS20655"
                     /old_locus_tag="HYG85_20570"
     CDS             complement(2881..3987)
                     /EC_number="4.2.3.5"
                     /GO_function="GO:0004107 - chorismate synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="aroC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012201100.1"
                     /locus_tag="HYG85_RS20655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20570"
                     /product="chorismate synthase"
                     /protein_id="WP_212691260.1"
                     /transl_table=11
                     /translation="MSTGSNFGKLFTISTWGESHGEAVGVVIDGCPAGVELTEEDIQIE
                     LNKRKPGKSIFSTPRKESDKANILSGVFEGKTTGTPISIVVYNNNQKSKDYSEISRFYR
                     PGHADMTYDMKYGFRDYRGGGRSSGRETIGRVAGGAIAKKILSTLNIKVTTYTKSIGNI
                     STSIDFDENEIWKNDLCIPNKSCVEKTENYLLDLIKDGNSCGGIIECRVDNLPSGLGEP
                     VFDRLDAELSKAVMSIGSIKGFEIGNGFSASKLTGIENNDFYRYENDVIKKESNNAGGI
                     LGGISDGSRIVLRAAVKPTPSIKTTQRTVNKSGENIDINIKGRHDPIIVPRAVIVVESM
                     VAITLVDMLFRNVNSRIDNIKKIYSKPQ"
     gene            4266..6578
                     /locus_tag="HYG85_RS20660"
                     /old_locus_tag="HYG85_20575"
     CDS             4266..6578
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025: diguanylate cyclase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012772.5"
                     /locus_tag="HYG85_RS20660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20575"
                     /product="EAL domain-containing protein"
                     /protein_id="WP_212691261.1"
                     /transl_table=11
                     /translation="MEISENFYYALINNIFSGYAYHKVITDSDGNPVDYEFIDINDDYC
                     NLVGFKREDIIGKRITEIIPSMVDESFDWINFFGKIAIEGSHGSTIQYFKPFDKWYQVN
                     VFSDKKGYFAEIFTDITEMKKKELLLKKKNEQLVKLFEEITASEEELRQQNEKLTQVYE
                     EIAASEEELRQQNEHISGLYEELVASEENLSEQNSLLQESNSIIKEKEQIYRLITQASN
                     DGIWYWNMRDGKRSISYDWYNDLGINLDLFSDIQSWHNILHPDDVEKARKSLKDCIAGI
                     TSSYESTYRVRTIRGEYKWIVSRGKTLRDADGKPYLMAGAHIDITNKKIKDDKIKYLAY
                     YDTLTGLPNRAYLLEQVSKYLEKNNKIALIVMDVDNFKSVNDSVGFSIGDIILKQVGLR
                     LSSSIAENDFIARLGGDEFAVILNDVDDNEDIIERANLVKDCFNEPFTAENNIHQLSIS
                     LGIAVSPYDGVDSKDLIKNADTAMYKVKNMCKNSISFFTQDMKEEFLKRINIEKQLKKA
                     LENNEFKLFYQPQFDMKTGGIRGFEALLRWINPKLGLVSPMTFIPIAEEIGIINEIGEW
                     VLKEACNQYKQWTYDFSFNGIISVNISPIQLKTHNFYNIVSDILKETGIKSGCLELEIT
                     ENLFIDALDSAKMLLNKLIELGVRISLDDFGTGYSSLSYLKSLPIDTLKIDKSFIKNTT
                     YTGVEREITRSVIDLVRKIGLETIAEGVENDKQLNFLYQSLCDNIQGFLTGKPMPADQV
                     VDIIKAGKVDLSQYIDK"
     gene            6729..7850
                     /gene="tgt"
                     /locus_tag="HYG85_RS20665"
                     /old_locus_tag="HYG85_20580"
     CDS             6729..7850
                     /EC_number="2.4.2.29"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tgt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) bTGT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004846221.1"
                     /locus_tag="HYG85_RS20665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20580"
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="WP_212691262.1"
                     /sec_met_domain="bTGT (E-value: 6.9e-156, bitscore: 516.9,
                     seeds: 1816, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYKLLNVDGRAKRAEVHTVHGVIQTPVFMNVGTAGAIKGAVSSMD
                     LKEIKCQVELSNTYHLHVRPGDDVIKKLGGLHKFMVWDRPILTDSGGFQVFSLSGLRKI
                     KEEGVYFSSHVDGRKIFMGPEESMQIQSNIASTIAMAFDECAPYPATREYMQNSVDRTT
                     RWLKRCKTEMNRLNSLEDTINKKQMLFGINQGGTYEDIRIEHAKVISELDLDGYAVGGL
                     AVGESHEEMYRILEEVVPHLPQNKPTYLMGVGTPINILESVERGVDFFDCVYPARNGRH
                     GHVYTNFGKLNLWNAKFQLDDRPIEEGCQCPACKHYSRAYIRHLLKAKEMLGMRLCVLH
                     NLYFYNTLMEEIREAIDKNEYQEYKNNKIENML"
     misc_feature    7904..7924
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 23.52"
                     /tool="antismash"
     gene            8054..8446
                     /gene="yajC"
                     /locus_tag="HYG85_RS20670"
                     /old_locus_tag="HYG85_20585"
     CDS             8054..8446
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: protein motif:HMM:TIGR00739.1"
                     /locus_tag="HYG85_RS20670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20585"
                     /product="preprotein translocase subunit YajC"
                     /protein_id="WP_113675544.1"
                     /transl_table=11
                     /translation="MSSLFVLEAGAGAQPSTAGSIGAMLIPMVILFGFMYLMLIRPQKK
                     RQREIDQMQSSINIGDSVMTNGGFYGKVVDSVNNVLIVELGTNKSVRVPIERNAVAAVK
                     EPDLTINRDDLIEDKKEDKEEKKDEE"
     gene            complement(8523..9368)
                     /locus_tag="HYG85_RS20675"
                     /old_locus_tag="HYG85_20590"
     CDS             complement(8523..9368)
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006863979.1"
                     /locus_tag="HYG85_RS20675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20590"
                     /product="PHP domain-containing protein"
                     /protein_id="WP_212691263.1"
                     /transl_table=11
                     /translation="MKKLIDLHIHTTASDGTYEPCELVEYASKKNIAAIAITDHDCISG
                     IKEAKKCGKIYNVEIVSGIEFSTRYNDTEIHLLGLYIDENDKTFVNGLNEIVDARESRN
                     IKMIEKLNDHGIDISLEDVLATSNSDVYTRAHFAKAMLNKGYVSSMREAFNKYIGNDSP
                     CYVPREKVTPEMAIELVLSCGGVPILAHPTLYNMDLRQLDNLISELSKIGLLGIEGLYS
                     LYNKSEEKYLKDFADKYGLVISGGSDFHGSNKPNIDLGVGRGNLEIPYSILEAIKAKRT
                     "
     gene            9510..9905
                     /locus_tag="HYG85_RS20680"
                     /old_locus_tag="HYG85_20595"
     CDS             9510..9905
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024082.5"
                     /locus_tag="HYG85_RS20680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20595"
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_113675542.1"
                     /transl_table=11
                     /translation="MGRTSRISKKPDINTQKIIVNVLKAIMIGYIITILCVLLLSFIVY
                     KYDLSNSQINIGRVIIIILATIIMGLLIGRSIGKNKWMYGAIAGVIYFVIFVIASIIIN
                     KNSGISGGAISLFFMCVGGSTLGGMLG"
     misc_feature    complement(9938..9953)
                     /note="TFBS match to AfsQ1, Two-component system AfsQ1-Q2,
                     activator of antibiotic production, confidence: weak,
                     score: 16.13"
                     /tool="antismash"
     gene            10001..10141
                     /gene="scfA"
                     /locus_tag="HYG85_RS20685"
                     /old_locus_tag="HYG85_20600"
     CDS             10001..10141
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012198901.1"
                     /locus_tag="HYG85_RS20685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20600"
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_113675541.1"
                     /sec_met_domain="TIGR03973 (E-value: 7e-26, bitscore: 88.0,
                     seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 1.2e-25, bitscore: 87.3,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHIKTLNSATLKKSLKNGGCGECQTSCQSACKTSCTVGNQTCEN
                     K"
     aSDomain        10270..10563
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYG85_RS20690_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="2.20E-29"
                     /identifier="RREFam024.1"
                     /label="HYG85_RS20690"
                     /locus_tag="HYG85_RS20690"
                     /protein_end="98"
                     /protein_start="0"
                     /score="92.6"
                     /tool="antismash"
                     /translation="MVHQYKMGDMNIVVDVYSGAIHVVDDIVYDVIESYEKLSSEDLLN
                     KLSSKYDKEVIIESINEVKELIDKELLFTDDTYKEAIISFKKREPVVKALCLH"
     gene            10270..11625
                     /gene="scfB"
                     /locus_tag="HYG85_RS20690"
                     /old_locus_tag="HYG85_20605"
     CDS             10270..11625
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009246763.1"
                     /locus_tag="HYG85_RS20690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20605"
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_113675540.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 3.7e-27,
                     bitscore: 92.6, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 4.8e-77, bitscore:
                     257.6, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.6e-15, bitscore: 55.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2.1e-11, bitscore: 42.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 3.3e-18, bitscore:
                     64.0, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVHQYKMGDMNIVVDVYSGAIHVVDDIVYDVIESYEKLSSEDLLN
                     KLSSKYDKEVIIESINEVKELIDKELLFTDDTYKEAIISFKKREPVVKALCLHIAHDCN
                     LCCKYCFAGEGEYHGDRSLMTSEIGKKSIDFLLENSGNRRNLEVDFFGGEPLMNFEVVK
                     DIVKYARSREKEYNKNFRFTITTNGILLDDDVMEFVNENMYNVVLSIDGRKEVNDRMRS
                     SKNGKGSYDIIMPKFEKMAESRNQENYYVRGTFTHFNLDFSQDVLHLADKGFKQVSIEP
                     VVAPADMPYALREEDIPYLCEQYDILAKEMIKRKEEGRDFNFFHFMIDLSQGPCVIKRL
                     SGCGSGTEYLAVTPWGDLYPCHQFVGIDEFKLGTVDEGITNLERRKEFKECCVYSKDKC
                     QNCWAKFYCSGGCTANAYQFHGNIYDTYEIGCELEKKRVECAIYMKAKEMME"
     gene            11841..13994
                     /gene="secD"
                     /locus_tag="HYG85_RS20695"
                     /old_locus_tag="HYG85_20610"
     CDS             11841..13994
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006442051.1"
                     /locus_tag="HYG85_RS20695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20610"
                     /product="protein translocase subunit SecD"
                     /protein_id="WP_212691264.1"
                     /transl_table=11
                     /translation="MKGKKIITLLLLVVIIACSVFVAVKGVGKDEIGGANNVKLGLDLA
                     GGVSITYTTVKDKPTDKELDDTVFKIRKRIDGMGYTEGQVYREGSDRVNVDIPNATNAE
                     EVLEELGKPGKLEFIDPEGNVVLTGQDVKNATAKMVSGEIDPYIISLELNESGKDKFYE
                     ATKKFVGQRIAIAYNGENIMEPIVNDPIKDGNASISNMGSMERAEAMASNIRIGALPLE
                     LEELRSNVVGATLGEEAVNTSVKAGIIGLALILLFMIIFYRIPGLAADIALVFYSSLVI
                     IILSIFKITLTLPGIAGIILSIGMAVDANIIIFSRIKEELALEKTLRASLKAGFKKATS
                     AILDGNITTLIASAILYLMGTGPIKGFAQTLAIGIIVSMFTALVITRLILGAFAGLGIK
                     NKKLYGIAQKTRAIKVVAKRKVWFSISIVIIVIGLLAMPIYNASKGTPLNYDIEFSGGS
                     TTLVNIGKTMSKAEMDSELTPIVVEATNDNSPQFQAVIDKKQVIIKTSKLDNESRTKLQ
                     EKLIEKYGITSEDIESESISPTISNEMRKSAMLSIILAAICMLIYITLRFKDYRFGVSA
                     VVALIHDVFIVLAVYSLFRVPINNSFIAAMLTIVGYSINDTIVLFDRVRENQKYMKRGD
                     FKGVVDTSISQTMSRSINTSLTTFLMVAILYVIGVASIREFALPLMVGILSGTYSSIFI
                     ASPLWYVFKRKEEKKIQQAHQQR"
     gene            14053..16128
                     /gene="recJ"
                     /locus_tag="HYG85_RS20700"
                     /old_locus_tag="HYG85_20615"
     CDS             14053..16128
                     /GO_function="GO:0008409 - 5'-3' exonuclease activity
                     [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /gene="recJ"
                     /inference="COORDINATES: protein motif:HMM:TIGR00644.1"
                     /locus_tag="HYG85_RS20700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20615"
                     /product="single-stranded-DNA-specific exonuclease RecJ"
                     /protein_id="WP_212691265.1"
                     /transl_table=11
                     /translation="MEPKYIWNLKQKNEKLVDELSEKYKLSTIMATILANRNIVVEKDI
                     VRFLNADKDKFYDPYLMKDMDKAVERIITAIDKNEKITIYGDYDVDGITSTSVLYMYLK
                     ENGAEVDYYIPNRLEEGYGVNDDAVKSIHQGGTKLIITVDTGITAILQVDLANSLGLDM
                     VITDHHECQESIPDAVAVIDPKREDCGYPFDMLAGVGVAFKVIHALSIKLGNIDSIWKY
                     LDIVAVGTVADIVPLKDENRIITKLAFKTMKDTWNVGLKALIKVSGNKKDDKITAGIIG
                     FRIAPRLNAAGRLGDAKRGIELFITEDKNKADDIAEKLNEENILRQQLEQEIFDEAVHI
                     IEENIDMDNTKIIVAASSNWHHGVIGIVASRITEKYYRPSILLSIEDGVATGSARSVDG
                     FSIFEALCSTKELFMKFGGHEMAAGMSLKEENIDRLREILNEYAENTMESDTLIPKLTA
                     DMEIDIKDISIPLIEEIIKLEPYGVGNPEPKFICKGKVNDVRKIGKESNHLKMRVDYNK
                     NYLDGIGFGMAQYYDYINVTHDISLLGTLNINEWNGTKKPQIMLKDINPNNEFVESLKR
                     YYDEFNNIKNANFDGKTKGYLQDEQVIPTRKEFETIYRTLLNLEKQMKETIIFTKLMQL
                     LGFEQPNKILTLLTCLEVFSELRLLEYRVENMNLSFKLNKGIRVKLDESSIYNKII"
     gene            16310..16477
                     /locus_tag="HYG85_RS20705"
                     /old_locus_tag="HYG85_20620"
     CDS             16310..16477
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS20705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_20620"
                     /product="hypothetical protein"
                     /protein_id="WP_212691266.1"
                     /transl_table=11
                     /translation="MGRSKRKLICDLIIVLVCLIVFIYLFGFECLVAFMPFACGAFIVI
                     LFIKLLEFFM"
     gene            16714..17226
                     /locus_tag="HYG85_RS20710"
                     /old_locus_tag="HYG85_20625"
     CDS             16714..17226
                     /EC_number="2.4.2.7"
                     /GO_function="GO:0003999 - adenine
                     phosphoribosyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009116 - nucleoside metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013657544.1"
                     /locus_tag="HYG85_RS20710"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20625"
                     /product="adenine phosphoribosyltransferase"
                     /protein_id="WP_212691267.1"
                     /transl_table=11
                     /translation="MDLKTLIREVPDFPKEGILFYDITTILQNPEGLKASIDQIQVKLE
                     GIEFDYIVGPESRGFIFGVPVAYNTGKGFLPIRKAGKLPYKTKSKEYALEYGTATIEMH
                     IDAIKPGDKVVIIDDLLATGGTSKATVELIESLGGEVVKLVYLIELDFLKGRDKLKNYD
                     VDSIIHG"
     misc_feature    17404..17416
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 22.66"
                     /tool="antismash"
     gene            17515..19725
                     /locus_tag="HYG85_RS20715"
                     /old_locus_tag="HYG85_20630"
     CDS             17515..19725
                     /EC_number="2.7.6.5"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0015970 - guanosine tetraphosphate
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002569017.1"
                     /locus_tag="HYG85_RS20715"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20630"
                     /product="bifunctional (p)ppGpp
                     synthetase/guanosine-3',5'-bis(diphosphate)
                     3'-pyrophosphohydrolase"
                     /protein_id="WP_212691268.1"
                     /transl_table=11
                     /translation="MPDKIYMDLLEVIRKYHPSEDFSMIQKAYQLAKTAHERQLRKSGE
                     PYIIHPLAVAHLLAELELDKESIMAGILHDVVEDTEYTIEYITNEFSKEVALLVDGVTK
                     LEKIPYSTDKEEIQAENYRKMFLAMSKDIRVILIKLADRLHNMRTLRYKSEEKQKKIAK
                     ETLDIYAPLAHRLGISKFKIELEDLSFRYLNPEAYYDLVEKIARKRDDRISFVDKIVVD
                     IKGEIDRIGIKAEVDGRPKHFFSIYKKMVGQNKTIDQIYDLFAVRAVVESVKDCYGVLG
                     VIHEMYKPIPGRFKDYIAMPKPNMYQSLHTTVIGPEGEPFEMQIRTYEMHRTAEYGIAA
                     HWKYKEGKTTQSMEQSEEQKLNWLRQILEWQRDMSDNKEFLDVLKSDLDVFADQVYAFT
                     PSGDVIDLPAGSTPIDFAYHIHSAVGNKMVGARVNGKIVTFDYKIKNGDRIEIITSQNS
                     HGPSRDWLNIIKSSQAKSKINQWFRKEFKEDNIVRGKELIEKYSKAKGIPLSDIIKPEF
                     TQAVKRKYGFKDWEAVCAAIGHGGLKEGQIVNRLYEEYKKKIKVANKNSEVVEEVFDIN
                     TSTAKQSKSGIVVKGVEDLAVRFSKCCNPVPGDEIIGFITRGRGVSIHRTDCSNIINLS
                     ELERHRLIEAEWQSLDEKESSRLYQVEIQIISSNRVGLLYDVSKVLTEERIPVKSLNAR
                     SNKGDKSIFNVTMDINGVNQLNKLTKKLRNIEGVEEIIRTNS"
     gene            19743..20192
                     /gene="dtd"
                     /locus_tag="HYG85_RS20720"
                     /old_locus_tag="HYG85_20635"
     CDS             19743..20192
                     /EC_number="3.1.1.96"
                     /GO_function="GO:0004045 - aminoacyl-tRNA hydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene="dtd"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002568982.1"
                     /locus_tag="HYG85_RS20720"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20635"
                     /product="D-aminoacyl-tRNA deacylase"
                     /protein_id="WP_113675535.1"
                     /transl_table=11
                     /translation="MRVVVQRVKHASVKVEGELIGEIGKGILVLVGFLDNDDMKVYDYM
                     LDKIINLRIFEDEDDKMNLSVKDIEGEIIIVPNFTLYGDCRKGRRPSYSVAAKPDKARM
                     IFDEFIKRANEKYDGIKQGMFQADMKVELLNDGPVTLLLDSEKVF"
     gene            20267..20893
                     /locus_tag="HYG85_RS20725"
                     /old_locus_tag="HYG85_20640"
     CDS             20267..20893
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1170: metallo-beta-lactamase family protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012955.5"
                     /locus_tag="HYG85_RS20725"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_20640"
                     /product="MBL fold metallo-hydrolase"
                     /protein_id="WP_212691269.1"
                     /transl_table=11
                     /translation="MKVKTMMLGILQTNVYIVYDEESKDAVVIDPAGDEDRIIRFIEEN
                     NLRLMGILITHGHFDHIGVVDAIRDNYGVPVFTSRQEGELMADPNKNLSLNLMRTVVAV
                     ENDEVVGDKDILEFGELEFDCIVVPGHSPESVCYYNKDNDVLFCGDTLFAGSIGRTDFY
                     DGPQNTLINSIKDRLMILPEETKVYPGHGFQTTIGYEKKTNIYMC"
ORIGIN
        1 gtggaactgt taataatgtt attactaata tgataccaac tacttttatt aaaataacta
       61 tgctcaaggc tataagaata aatagaaagt attctaaaaa cgtagtatta acccctttgc
      121 tgcttaaaaa gatttcatca aacaaataac tttttatata gttgaataat gcaaatgaac
      181 ttataagaat aaaaagagtc aaaataacca taagataaat atcttttact gaaacggtta
      241 atatatctcc aaataaataa gtagtcatat ctggtgggta accaggtgta agagatatga
      301 atagtatccc aagtgccata cctaatgacc atagcatacc tatgattgta tccgaagtag
      361 tattagtcct tctttttata ctgacaatgg caattgctga tattactgca aacaaaagtc
      421 ctcctattat aggttcaaac cctaatagaa aaccaagacc tatacctccg aaagatgcat
      481 gagcgatacc gccactcatc atcaccaatt ttttttctac aacaattgtt ccgattattc
      541 cacatacaat actagctaag ataatactta tgatagcatt ttgcatgaaa ccatatttac
      601 atattgcttc taacataact actttccttt cgtataaaat aaattttgaa aatgccaagg
      661 atctattgtt tcgtcgttgt catgaacatg catagtctta ttaagacatg caaatttttt
      721 tacattatgt tttatcatac caatatcatg actaaccata attattgtca tttctttatt
      781 caatgtagtc aagatattgt aaatttcctc ttttgcatct gtatctagac tagctgttgg
      841 ttcatcaagt aataaaatat ctggattagt tactaatgct cttgcaagta atactttttg
      901 taattgacca ccagatagtt gattgattct tttattcgct agataattga tttttaactt
      961 atctattgca aatataactt tatttctatc attttgttta taacggtaga acagcttata
     1021 atctgatgga agagtaccac ttaatatcac atcaaatact gttataggaa aatccctgtt
     1081 gaatgttgag aattgaggaa cgtaacctat aattacattt ggatctatca ttattttacc
     1141 tttatcagga gtaatatcac ctattatgga tttcaaaaga gttgttttgc cacttccatt
     1201 aggtccaatt attccaatat aatcattttt attaacttct aaattgatat tatccagtgc
     1261 tagataatta ttatagtgaa cggataaatt ttttatttct aataatgcca tattagtcac
     1321 ctttttaata tgaagataca aaagtatcaa cgattttttt gtagttatca atatattctt
     1381 ttgataaaat atccagagaa attactttcc cattgatttc atctgcaatg actgttgctt
     1441 gtttgctatc aaattcttgt tggtagaaca caacttttat atcatgttct tttgcaaaat
     1501 taatcacatt agtcatagtt tcaatagttg cagttttacc atcttcttca ataaccatca
     1561 tatttaaacc ataatcgtta gcgaaatagc caagtgaagg atgatatatg atgaaattat
     1621 ctatattaga gtttttcaga gtctcttcta tataaatatc caattcttct agttcggcga
     1681 tatattttgc tgcattgtca tcatagtaat ctttattttc agggtcaata tcagaaagag
     1741 aatcccttat tgtattaatc atgactatta ctctttttgg tgacatccat atatgagggt
     1801 caattacttt gctagtttct tcttcctcat gttcggtagt ttcttcatgt tcatgctcat
     1861 gtgaatgatt atctaaataa agaatagggt attgtttttc agaagcatcc tttagtgaga
     1921 taacttctgt tttattactt actaccttag gtaatatatt attttcagcg gctactccaa
     1981 tggtaaaata caagtcagca tcactgatat gttctaattc ttttggcgaa ggctgatagt
     2041 ttgcaggact aaagcctgag ggtataacag ttgtaacagt gcctttatca ccaagcacag
     2101 cattgacaaa tgcttcttct ggtccaatgg atactcctat attaattttg ttgttatcta
     2161 cagatttacc agaacaccca gatagtatta atacgatgga tgctagtaat aataatcttc
     2221 ttttcatatg aatcctccta tataattcta aatgcaaata atttgcattt aaattatact
     2281 atttaattat agtattgaca agtacaaatc tattaaaaaa ataattttat tggtttaaaa
     2341 agtgcatgta tatgttataa taaattaacg acaagtaatc ttcttagaat aaaggtgttt
     2401 tatatggatt ttaataaagt tattgatcta ttaaaaaata gtggttataa attgaccaat
     2461 cagagaaaga ttatcataga agctctttat catagtgaca aaccaatatc tatggaggaa
     2521 tggttattgt tgactaaaga taagaatcca ggtattaatc tatcaactat ctatagaaat
     2581 attgatgtat tagaggattt ggggctacta gaaaaaatca gaccaaaaga tgacagcatt
     2641 aagtataccc ttaatctaat ggaaaatcat tcgcattttc tgatttgtaa aagatgtggt
     2701 aaagcagaag caatagaatg ttgtcttagt aaagaattca aaaaggttat tgaggacaaa
     2761 gaatttgatt tgattgaaca taatctagaa ttatatggat attgtaaaga atgtcataat
     2821 gaattggata aaaaataata atggggttgt ttcacattgt gagacaaccc attaataata
     2881 ttattgtggc ttagaatata ttttcttgat gttatcaatt ctgctgttta cgtttctgaa
     2941 taacatgtca accaaagtaa tagctaccat tgattctaca acaattacag ctcttggaac
     3001 tataataggg tcatgtctgc cttttatatt gatatcaatg ttttcaccag atttgttaac
     3061 ggttctctgg gtggttttaa tagaaggagt aggttttact gctgctctta atacgatacg
     3121 agaaccatcg cttatgcctc ctaatatacc cccagcattg ttggactctt ttttgattac
     3181 atcattttca tatctataga aatcgttatt ctcaatacct gttaacttgg aagctgagaa
     3241 tccattacct atttcaaaac ctttgatact tcctattgac atgacagctt ttgacagttc
     3301 agcatctagt ctatcaaaaa caggttcgcc aagcccagat ggaaggttat ccactctaca
     3361 ttcaataatt cctccacaag aattaccatc tttaattaaa tcgagtagat agttttcagt
     3421 tttctctaca caagatttat tgggtataca taggtcattt ttccagattt cattttcatc
     3481 gaaatctata cttgtggata tattcccaat ggattttgta tatgttgtta ccttaatatt
     3541 aagagtagat aatatttttt ttgcaattgc accaccagcc acacgtccta tggtttctct
     3601 acctgaagaa cgacctccgc ctctatagtc tctaaatccg tatttcatat cataagtcat
     3661 atcagcatgt ccaggacgat aaaatctgga tatttctgaa taatcctttg acttttgatt
     3721 gttattataa acaactatag atataggagt acctgtggtt tttccttcaa acacaccaga
     3781 taatatatta gccttgtcag actcttttct aggtgtagaa aaaatagatt tacctggttt
     3841 tcgtttattt aattcaattt gaatatcttc ttctgttaat tcaacaccag ctggacatcc
     3901 gtcgataact actccaactg cttcaccatg ggattcgccc catgtagata ttgtaaatag
     3961 ttttccaaag ttggaacctg ttgacatata atcaccttct atactttata gcttgccata
     4021 tattatatac aattcttaac aattagacaa gataataata attttttata ttaaatctag
     4081 taaatagtgt aaaaaaaatt acattttttg acatgaatat aaaaaaatat ttataaatgt
     4141 gatataatat attagaataa ctataaaggg taaatttgac aattaaaaaa agatataaat
     4201 tatatggtta tgttcaattt taaatcatat tataaacaat aattttacta agatggggtg
     4261 ttcgaatgga gatatctgaa aatttttatt acgccttaat taacaatata tttagtggat
     4321 atgcatatca taaagtaatt acagattctg atgggaatcc tgtagattat gagtttatag
     4381 atattaatga tgattattgt aatttagtgg gttttaaaag agaagatatt attggaaaaa
     4441 gaataactga aattattcca agcatggtgg atgaatcatt tgattggatt aatttttttg
     4501 gtaagatagc aattgagggt agccatggtt ctactataca atattttaaa ccatttgata
     4561 aatggtatca ggtaaatgtg tttagtgata aaaaagggta ttttgcagaa atatttactg
     4621 atattactga gatgaagaaa aaagagctat tactgaagaa aaagaatgag cagttggtca
     4681 aattattcga ggagataact gcatcagaag aggaactgag acaacaaaat gaaaaattaa
     4741 ctcaagtata tgaagagatt gctgcatcag aagaagaatt aagacagcaa aatgagcata
     4801 tcagtggatt atatgaagag ttagtggcgt cagaagaaaa cttgagtgag caaaatagtt
     4861 tattgcaaga gagtaatagc ataataaaag agaaagaaca aatatataga ttaatcacac
     4921 aggcatctaa tgatggtatt tggtactgga atatgagaga tgggaaaaga agtatatcat
     4981 acgactggta taatgactta ggtatcaatc tagatttgtt ttctgacatt caaagttggc
     5041 ataatattct tcatccagat gatgttgaaa aagctagaaa aagtttgaag gattgtattg
     5101 caggaataac ttcaagttat gaaagtactt atagggtacg tactatacgt ggtgaataca
     5161 aatggatagt ttctagagga aagactttgc gtgatgctga tgggaaacct tatttgatgg
     5221 ctggtgcaca tatagatata accaataaga agattaaaga tgataaaata aagtatttag
     5281 catactatga tactcttaca ggtctgccga atagagcata tctattagaa caagttagca
     5341 aatatttaga gaaaaataac aaaatagcat taatagtaat ggatgttgat aacttcaaga
     5401 gtgttaatga tagtgttggt ttctcaatag gtgatattat cctaaaacaa gtaggattaa
     5461 gattgtcaag ctccattgct gaaaatgatt ttattgcccg ccttggaggt gacgaatttg
     5521 ctgtaatact gaatgatgtc gatgataacg aagatataat agaaagagcc aatctagtta
     5581 aagattgttt taatgaaccg ttcactgctg aaaataacat acatcaattg agtattagtt
     5641 taggaattgc ggtttcacct tatgatggag tcgattcaaa agacttgatc aagaatgctg
     5701 atactgcaat gtacaaagtt aaaaacatgt gcaaaaacag tatatctttt tttacacaag
     5761 atatgaaaga agaatttttg aagagaataa atattgaaaa acaattgaag aaagcattag
     5821 aaaataatga attcaagctt ttttatcagc ctcaatttga tatgaaaaca ggtggtataa
     5881 gaggttttga agcattgctt agatggatta atccaaaact gggattggta agtcctatga
     5941 catttattcc aatagcagaa gaaataggaa taatcaatga aataggagaa tgggttttga
     6001 aggaagcgtg taatcaatat aagcaatgga cttatgattt ttcatttaat ggtattatat
     6061 ctgtaaatat ttctcctatt cagttgaaaa cacataactt ttataatatc gtttctgata
     6121 tcttaaaaga gacaggtatc aaatcaggtt gtttggaatt agagataacg gagaacttat
     6181 ttattgatgc tctagactca gcaaaaatgc tattgaacaa attgattgag ttgggagtca
     6241 gaatatcatt ggatgatttt ggaacaggat attcttcatt gagttatctg aaatcattac
     6301 ctattgatac tcttaaaatt gataaatcct tcattaagaa tactacatat acaggagtgg
     6361 aaagagaaat tactagatcg gttatagacc tagtaaggaa aatcggtctt gaaactatag
     6421 ctgaaggtgt ggaaaatgat aagcagctta acttcctata tcaatcatta tgtgataaca
     6481 tacaaggttt cttaacaggt aaaccaatgc ctgcagacca agtagttgat ataatcaaag
     6541 cgggaaaagt agacttgtca caatatatag ataagtaatg gttatacata ttttaagcag
     6601 attgtttatg acaatttgtt aagattaaga ttaagttaga ttgtataata tgtccttgaa
     6661 atgttaataa attagttgta tacttggtag acgtgtaaaa aacaaaaaat tgacgaatgg
     6721 tgattaaagt gtataaatta ttgaatgtag atggaagagc aaaaagagca gaagtgcaca
     6781 cggttcatgg tgtgattcag actccggttt ttatgaatgt tggtactgca ggagctataa
     6841 aaggtgcagt ctcaagtatg gatttaaaag aaatcaaatg tcaagttgaa ttatcaaata
     6901 cttatcatct ccatgtcaga cctggagatg atgtaattaa gaaattggga ggacttcaca
     6961 aattcatggt atgggataga ccaatactta cggattctgg aggatttcaa gttttttcac
     7021 tttctggtct tagaaaaatc aaagaagaag gagtatattt ttcttctcat gtagatggac
     7081 gtaaaatatt catgggacca gaagagagta tgcaaatcca atcaaacatt gcttcaacaa
     7141 tagccatggc atttgatgaa tgtgccccat atccagcgac aagagaatat atgcagaatt
     7201 ctgttgatag gacaactaga tggttgaaaa gatgtaagac tgagatgaat agacttaatt
     7261 cccttgaaga tactatcaat aaaaaacaaa tgctttttgg aattaatcaa ggtggaactt
     7321 atgaagatat aaggatagaa catgctaagg ttatttcaga attagacttg gatggatatg
     7381 ctgttggagg actagcagta ggagaatctc atgaagaaat gtatagaatt ctagaagaag
     7441 tagtcccaca ccttccacag aataaaccaa cataccttat gggggtagga acacctatta
     7501 atatcttgga atctgttgaa agaggagtag atttctttga ctgtgtatat ccagccagaa
     7561 atggaagaca tggtcatgta tatactaatt ttggtaaact caatttatgg aatgcgaaat
     7621 ttcagctaga tgacagacca atagaagaag gctgccagtg tccagcatgt aagcattata
     7681 gcagagcata tataaggcat cttctaaaag ctaaagaaat gctgggtatg cgattatgtg
     7741 tacttcataa tttgtatttc tataatacac ttatggaaga aataagagaa gctattgata
     7801 aaaatgaata ccaagaatat aaaaataata aaatagagaa tatgttataa gaaattatat
     7861 aaaattttct aacaaatatt aggaaaatat attgaactta ttattatggt tatatagatg
     7921 attaagttga aatatatgga taaaacagtt gacaggaagt tattaacagt gtatcttatt
     7981 atataagaat aatgattctt acaagctacc gaatagataa atttctgtgt aaaaacaagg
     8041 aggataataa tttatgtcaa gtttatttgt attagaagct ggagctggcg cacaaccatc
     8101 tactgctggc agtataggtg ctatgttaat acctatggta attttatttg gttttatgta
     8161 cctaatgctt atcagacctc aaaaaaagag acaaagagaa atagaccaaa tgcagtcaag
     8221 cattaatatt ggtgattctg ttatgactaa tggtggtttc tatggtaaag ttgttgattc
     8281 tgtaaataat gttcttatag ttgaacttgg tactaacaaa agcgtaagag ttcctattga
     8341 aagaaatgca gttgctgcag ttaaagaacc agatttaaca ataaatagag atgacttaat
     8401 cgaagataaa aaagaagaca aagaagaaaa gaaagacgaa gaatagaatt aatgggtttt
     8461 acacaagggc tgtatatgat tacagccctt ttatattttt attaaagaaa agtctacagt
     8521 cattatgttc tcttagcttt tatagcttca agtatagaat aagggatttc tagattgcct
     8581 cttcccacac caagatcgat atttggctta ttgcttccgt gaaaatcaga acctccagag
     8641 attacaagac catatttatc tgcgaagtct ttcaaatatt tttcttcaga tttattgtat
     8701 agagaataaa gtccttcaat tcctaacaaa cctatttttg ataactcact aataagatta
     8761 tctaattgtc ttaaatccat attgtataga gttggatgtg ctagaatggg tacaccacca
     8821 caggataaga caagttctat agccatttct ggagtaactt tttctcttgg tacatagcaa
     8881 gggctatcat tgcctatata tttgttaaag gcttctctca tagatgaaac atagccttta
     8941 ttaagcatag ccttagcaaa atgagctctt gtataaacat cggagttaga tgttgccaaa
     9001 acatcttcta gggaaatgtc tattccatga tcattaagtt tttctatcat tttgatattc
     9061 cgtgattctc tagcatccac tatttcattt aatccattta caaatgtttt atcgttttca
     9121 tcaatatata aacccaaaag gtgtatttca gtatcattat atcttgttga aaattcaata
     9181 ccgctaacta tctctacatt atatatttta ccgcatttct tagcttcttt aattccagag
     9241 atacagtcat ggtcagttat agcaatagca gctatatttt tttttgaagc atattctact
     9301 aattcacagg gctcataagt tccatcagaa gcagtcgtat gaatatgtag atctataagt
     9361 tttttcaaat aaaatcagtc cttcctacat aatatatata tgtgcaataa ataatacgat
     9421 tatttacaaa ccacaattta aataaaagca tggcatattt taaattatag cacagtataa
     9481 tattatatgg aacaataagg gggaggatta tgggcagaac atctcgaatt tcaaagaaac
     9541 cagacattaa cacgcaaaaa ataatagtga acgtgcttaa agctattatg attggataca
     9601 taattactat tttatgtgta cttcttcttt cattcatcgt atataagtat gatttgagta
     9661 atagtcagat taatattgga agagtcatta ttataatatt ggcaactatt attatgggct
     9721 tactaatagg aagaagcata ggtaaaaata aatggatgta tggcgctata gccggagtta
     9781 tttattttgt gatatttgtc atagcatcta ttataatcaa caagaatagt ggaatttctg
     9841 gaggtgcaat aagtttattc ttcatgtgtg taggtggcag tacattagga ggaatgctag
     9901 gataagttac aagttacttt aaaatctact tttaaaagtg acaatcttgt gatataatgt
     9961 tttaagttaa agtaacaggt gcttaaagga ggaaaaagca atgaagcata ttaaaacatt
    10021 aaactcagct actcttaaaa agagtttaaa aaatggtgga tgcggcgaat gccaaacatc
    10081 atgccaatca gcatgtaaaa catcatgtac agttggtaat caaacttgtg aaaacaaata
    10141 atttataagt ttattaagca gtgacgttag tcgctgctta tattaggttt gatggatact
    10201 ttattatcaa agtattttat taatttagct gtattacata tagttaagca taagaaagga
    10261 agaataacag tggtacatca atataaaatg ggcgatatga acatcgtagt agatgtttat
    10321 agcggtgcaa ttcatgtagt tgatgatatt gtttatgatg taatagaaag ttatgagaag
    10381 ttatctagtg aggacttatt aaacaagctt tcttcaaaat atgataagga agtaataatt
    10441 gaatcaatta atgaagtaaa agaacttatt gataaagaat tactttttac tgatgataca
    10501 tacaaagaag caattatcag ctttaaaaaa agagaacctg ttgtaaaagc tttgtgtttg
    10561 catatagcac atgattgtaa cttgtgttgc aagtattgtt ttgcaggtga aggtgaatat
    10621 catggagacc gttcacttat gactagtgaa ataggtaaaa aatccattga ttttctatta
    10681 gagaattcag gtaatagaag aaaccttgaa gtagatttct ttggtggaga accattgatg
    10741 aattttgaag tagtaaaaga cattgtgaaa tatgctagat ctagagaaaa agaatataat
    10801 aagaacttta gatttacaat aactactaat ggaatattac ttgatgatga tgtaatggaa
    10861 tttgttaatg aaaacatgta taatgtagta cttagcatag atggtagaaa agaagtaaat
    10921 gatagaatga gatcatccaa aaatggcaag ggtagttatg atatcataat gcctaagttt
    10981 gagaagatgg ctgaaagtag aaatcaagag aattattatg taagaggaac tttcactcat
    11041 tttaatcttg atttttcaca ggatgtatta catctagctg ataaaggatt caaacaagta
    11101 tctatagaac ctgttgtagc accagcggat atgccttatg ctcttaggga agaggatata
    11161 ccatatctat gtgaacaata cgatatatta gcaaaagaaa tgattaagag aaaagaagaa
    11221 ggtagagatt ttaatttctt ccacttcatg attgacttat cacaaggacc atgtgtcata
    11281 aagagacttt caggttgcgg ttcaggaact gaatacctgg ctgttacacc atggggtgat
    11341 ttgtacccat gtcatcaatt tgtaggaata gatgaattca aacttggaac agttgatgaa
    11401 ggaataacta atctggaaag acgtaaagaa ttcaaagaat gttgtgtata ttcaaaagat
    11461 aaatgtcaaa attgttgggc aaaattctat tgtagtggtg gatgtacagc taatgcatat
    11521 caattccacg gtaatatata tgatacatat gaaataggct gtgagcttga gaaaaaacga
    11581 gttgaatgtg ctatttatat gaaagcaaaa gaaatgatgg aataatacat tatataaatt
    11641 atcttgacta attttaagat aatatttata atttaacgta gtatgtaagt tataatatat
    11701 atgaatagaa ggtctgatat ttatttaagt ataacttaca aaataattaa tatatattga
    11761 catctataga atatattgta gattcaatat aaaaaattag aaattaaata tgataatgta
    11821 caaaggagga tattgttgca atgaagggga aaaaaattat taccctattg cttttagttg
    11881 ttataatcgc atgttctgta tttgtagcag ttaaaggagt aggaaaagat gaaatcggtg
    11941 gagcaaacaa tgtaaaatta ggtcttgact tagctggtgg tgttagtata acatacacta
    12001 ctgtcaaaga taaaccaact gacaaagaac tagatgacac agtctttaaa atcagaaaaa
    12061 gaatagatgg aatgggttat acggaaggac aagtctacag agaaggttct gaccgtgtaa
    12121 atgtggatat tcctaatgca acaaatgcag aagaagtatt agaagaactt ggtaaaccag
    12181 gtaaactaga attcattgat ccagaaggaa atgtagtatt aactggacaa gatgttaaga
    12241 atgctactgc aaaaatggta tcaggagaaa ttgacccata tattatctca cttgaactta
    12301 atgaaagtgg aaaagataaa ttctatgaag ctactaaaaa gtttgtaggt caaagaatag
    12361 ccattgctta taatggtgaa aacataatgg aacctatagt taatgatcca atcaaagatg
    12421 gtaacgcttc tatcagtaat atgggaagta tggaaagagc ggaagcaatg gcatctaata
    12481 tacgtatcgg tgcacttcct ctagaacttg aagaattaag atcaaatgta gtaggagcaa
    12541 cacttggtga agaagcagtt aatacaagtg taaaagctgg tattatcggt cttgctttaa
    12601 tattattatt tatgataata ttctatagaa tacctggact tgctgctgac atagcattag
    12661 tattctattc ttcattagta attatcatat taagcatatt caagattaca ttaacattac
    12721 ctggtattgc aggtatcata ttatcgatcg gtatggctgt agatgccaat ataattatat
    12781 tctcaaggat aaaggaagaa ttagcacttg agaaaacact tagagcttca ctgaaagctg
    12841 gatttaaaaa agctacatca gctattttag atggtaatat aacaacatta atagcatcag
    12901 ctatcctata tctaatggga actggaccaa tcaaaggttt cgctcaaact cttgcaattg
    12961 gtattattgt ttctatgttt acagctctag taattactag acttatccta ggagcttttg
    13021 ctggattagg aatcaagaat aaaaaattat acggtattgc tcaaaaaaca agagctatca
    13081 aagttgttgc aaagagaaaa gtttggttta gtatctcaat tgttattata gttataggac
    13141 ttcttgcaat gccaatatat aatgcttcaa agggtactcc tcttaattat gatatagaat
    13201 ttagtggtgg ttctacaact cttgttaaca taggaaaaac aatgagtaaa gctgaaatgg
    13261 atagtgagtt gacaccaata gttgttgaag cgactaatga taacagtcct caattccagg
    13321 cagttataga taagaaacaa gtcattatca aaactagtaa attagataat gaatcaagaa
    13381 ctaaattaca agaaaaattg attgagaaat acggtataac ttctgaagat attgaaagtg
    13441 aaagtataag tccaacaatc agtaatgaga tgcgtaagag cgctatgcta tctataatat
    13501 tagctgctat ctgtatgttg atatatataa cattaagatt caaagattat agattcggtg
    13561 ttagtgcggt tgttgcatta attcatgacg tatttattgt attagcagta tattcattat
    13621 tcagagtacc tatcaataat tcattcattg ctgcaatgtt aacgattgtt ggttactcaa
    13681 tcaatgatac aatagtttta tttgaccgtg ttcgtgaaaa tcaaaaatat atgaaacgtg
    13741 gagatttcaa aggtgttgtt gatacatcta taagtcaaac aatgtcacgt tcaataaata
    13801 catcacttac aactttcctt atggttgcga tactatatgt aattggtgtt gcttcgatta
    13861 gagaatttgc tctaccatta atggtaggta tcctttcagg aacatattct tctatattta
    13921 ttgcaagtcc attatggtat gtatttaaaa gaaaagaaga aaagaaaatt caacaggcac
    13981 atcaacaaag ataattgaac ttacatccct ctagcaaatc tttgctaggg ggattttttg
    14041 gaggttgttt atttggaacc aaaatacatc tggaacttaa aacagaaaaa cgaaaaactt
    14101 gtagatgaat tatctgaaaa atacaagctg tctactataa tggcaactat attagctaac
    14161 cgtaatattg tagtagaaaa agatattgtc aggtttctta atgcagataa agacaaattc
    14221 tatgatccat acttaatgaa agatatggac aaagctgtag aacgtatcat tacagcaata
    14281 gataagaatg agaaaataac tatatatgga gattatgatg tggatggtat cacaagtaca
    14341 tctgttctat atatgtatct aaaagaaaat ggcgcagagg ttgattacta tatacctaat
    14401 agattagaag aaggatatgg ggttaatgat gatgctgtaa aaagtataca tcaaggtggc
    14461 acaaagttga ttattactgt tgatacaggt attacagcca tattacaagt agatttagct
    14521 aattcattag gattggatat ggtaataaca gaccaccatg aatgtcaaga aagtatacct
    14581 gatgccgtag ctgtaattga tcccaagcga gaagactgcg gatatccatt tgatatgtta
    14641 gcaggtgtag gtgttgcttt taaagtaatt catgcattat caataaaatt aggtaatata
    14701 gattctatat ggaaatattt agatattgta gctgttggta cagtggctga tatagtacct
    14761 ttaaaagatg aaaataggat tattaccaag ttggctttta aaaccatgaa agatacttgg
    14821 aatgtgggtc taaaagcact aataaaagta tcaggaaata aaaaagatga taaaataacg
    14881 gctgggataa ttggattccg tatcgctcct agattaaatg cagctggtag acttggagat
    14941 gccaagagag gaatagaatt atttatcaca gaagataaga ataaagcgga tgatattgct
    15001 gaaaaactca acgaagaaaa tattctgcgt caacaattgg agcaagagat atttgatgaa
    15061 gctgtacata taatcgaaga aaatattgac atggataata ctaaaatcat agtggcagca
    15121 tcaagtaatt ggcatcatgg agtaattggt attgtggctt ctagaattac tgagaagtat
    15181 tatagaccaa gtatactgtt aagtattgaa gatggggtag ctactggttc agcaaggagt
    15241 gtagatgggt ttagcatatt tgaggcttta tgttctacca aagagctttt tatgaagttt
    15301 ggaggacatg agatggcagc tggtatgtca ttgaaagaag agaatattga tagacttaga
    15361 gaaattctca atgaatatgc cgaaaatact atggaatctg acacactaat accaaaatta
    15421 actgctgata tggaaataga tataaaagat atcagcatac ctcttataga agaaattatt
    15481 aagttggaac cttatggtgt aggaaatcct gaacccaaat tcatatgtaa agggaaagtt
    15541 aatgatgtta gaaaaatagg taaagagagt aaccatctga agatgagagt agattataac
    15601 aagaattatt tggatggaat aggattcggg atggcacagt actatgatta tattaatgtg
    15661 acccatgata tatcattgtt aggaacgttg aatataaatg aatggaacgg tactaaaaaa
    15721 cctcaaatca tgttgaagga tattaatcct aataatgagt ttgtagaatc attaaaaagg
    15781 tattatgatg aattcaataa cattaaaaat gcaaattttg atggaaaaac taaaggatat
    15841 cttcaagatg aacaagtaat tcctactaga aaagagtttg aaactatata tagaaccctc
    15901 ttgaatctgg aaaaacaaat gaaagaaact attatattca ctaaattaat gcagctgctg
    15961 ggttttgaac aaccaaataa aatattgacc ttattgactt gcctagaggt atttagtgaa
    16021 cttagattat tagaatatag agtagagaat atgaatttga gttttaaatt gaataaaggc
    16081 atcagagtca agttagatga atcaagtata tataataaaa taatttaaaa tgaaatatta
    16141 catatgttct ttaaataata ttattgaaaa acatacatta tatgtgctat attgaattaa
    16201 tgtcttaatg atatgaaaaa taatagatgt aatattgaat atattcaata aacaaattat
    16261 aattaaaagg attatatcaa aatttatatc tattattgga ggtctcttaa tgggaaggtc
    16321 taaacgtaaa ttaatttgtg atttaataat agtattggtt tgtttaatag tattcatata
    16381 tctttttggc tttgaatgtt tagtagcttt tatgcctttt gcttgtggtg cttttatagt
    16441 tatattgttc attaaattat tagagttttt tatgtaggag atatatttct taataaaaac
    16501 ttgaaaaagc tttgctagaa gctattaaat ttggtatact aatattgtat gtttaattat
    16561 gtttgaaaag ctataagtta aacatataaa tttgataaat aaatatcctt ttaaggcact
    16621 actattttta aaagtaatta atgatataca ttattttata ttattatagt ctaattaatt
    16681 ccttataggg tatatgaaaa ggagtaagga agtatggatc ttaaaactct tataagagaa
    16741 gtacctgatt tcccaaaaga aggtatttta ttttatgaca ttactacaat tttacaaaat
    16801 ccagaaggat taaaggcttc tatcgatcag atacaagtta aattggaagg tattgaattc
    16861 gattacatag ttggaccaga atcacgaggc tttatttttg gtgtaccagt agcttataat
    16921 acgggtaaag gatttttacc tatcagaaaa gctggtaaac taccatataa aacaaaaagc
    16981 aaagaatatg ctttagaata tggtactgcg actattgaga tgcatattga tgctattaaa
    17041 ccaggcgata aagttgtaat tatagatgat ttattagcaa caggtggaac atcaaaagct
    17101 accgtagaat taattgaaag tttaggagga gaagttgtaa agttagtata tttaatcgag
    17161 cttgacttcc taaaaggcag agataaatta aaaaattatg atgtagattc tattatacat
    17221 ggataaaaat aagaccttta ctttgaataa gttaaagtaa aggtcttatt tttattattt
    17281 tttatctctt tttctcaata gaacatttat ccagtaatag cgtataatac atactaaata
    17341 ataatatata ttattctata aattattatg ctgaatagat taaagtttag agtgcaataa
    17401 ttcttgcatt ttgtaagaaa aaaaactata atatatagat atattagatt catcaataat
    17461 tcagtttgaa aaactagaaa tactaaataa aatgtaaata gaagcggtga tgaaatgcct
    17521 gataaaattt atatggattt attagaagta ataagaaaat accatccatc cgaagatttt
    17581 tctatgattc aaaaagcata tcaacttgct aagacagcac atgaaagaca gcttaggaaa
    17641 tcaggggaac cctatataat acatcctttg gctgttgctc atttgttagc tgaactagag
    17701 cttgataaag aatcaataat ggctggtata cttcatgatg ttgtagaaga tacagaatat
    17761 acaatagaat atattacaaa tgaattcagt aaggaagttg ctctattggt tgatggagta
    17821 actaaactag aaaaaatccc ttattctaca gataaagaag aaatacaagc ggaaaattat
    17881 agaaaaatgt ttttggctat gtcaaaggat atacgtgtaa tccttataaa attggcagac
    17941 agacttcata atatgcgtac cctaagatat aagtcagaag aaaagcagaa gaagattgct
    18001 aaggaaacat tggatattta tgctccttta gctcatagat taggtatttc aaaatttaaa
    18061 attgaattag aagacctgtc tttcagatac cttaatcccg aggcctatta tgatctagtt
    18121 gaaaagatag ctagaaaaag agatgataga attagcttcg tagataagat tgttgtagat
    18181 ataaaaggtg aaatagatag gattggaata aaagcagaag tagatggtcg accaaaacac
    18241 ttctttagta tttataaaaa gatggttgga caaaataaga ccattgatca aatatatgat
    18301 cttttcgcag taagagctgt tgtagaatca gttaaagact gttatggagt cttaggtgta
    18361 atccatgaaa tgtataaacc aataccaggg aggttcaaag actatattgc tatgccaaaa
    18421 cctaacatgt atcaatcgtt acatacaacg gttattggtc cagaaggaga acctttcgaa
    18481 atgcagatca gaacatatga aatgcataga actgctgaat atggtattgc tgctcactgg
    18541 aaatataaag aaggtaagac aacacagtca atggagcaga gcgaggaaca aaaactaaat
    18601 tggttaagac agattttgga atggcagaga gacatgtctg ataataaaga attcctggat
    18661 gttctcaaat cagatttaga tgtttttgcc gatcaggtat atgcatttac accttcaggt
    18721 gatgtaatag atctaccggc tggttcaacg cctattgact ttgcttatca tatccatagt
    18781 gctgtaggaa ataaaatggt aggggctaga gtcaatggaa aaatagttac atttgattat
    18841 aagatcaaaa atggagatag aattgaaata attacttcac agaattctca tggtccaagt
    18901 agagattggt taaacatcat aaaaagctca caagctaaaa gtaaaatcaa tcagtggttc
    18961 aggaaagaat tcaaggaaga caatattgtc agaggtaaag aattaataga gaaatattca
    19021 aaagccaagg ggatacccct tagtgatata atcaaacctg aatttacaca agccgttaaa
    19081 agaaaatatg gcttcaagga ttgggaagct gtatgtgctg ctataggtca tggaggcttg
    19141 aaggaaggac agatagtcaa taggctttat gaagaatata aaaagaaaat taaggtagcc
    19201 aataaaaata gtgaagtagt tgaagaagta tttgatataa acacttcaac agcgaagcag
    19261 tccaaaagtg gcattgttgt aaaaggtgta gaagatttgg ctgttagatt tagtaaatgc
    19321 tgtaatccag tacctgggga cgaaataata ggatttatta ctagaggtag aggtgtatca
    19381 atacatcgaa cggattgtag taacatcatt aatctatcag aattggaaag acatagattg
    19441 attgaagctg aatggcaaag tctggatgag aaagaatcta gtcgtctata tcaggttgaa
    19501 attcagataa taagttctaa tagagtaggt ttattgtatg atgtatcaaa agtattaact
    19561 gaagaaagaa tacccgtaaa atcattgaat gctcgttcca ataagggtga taaatctatt
    19621 tttaatgtaa ctatggacat caatggtgtt aatcaattga ataaacttac taaaaagtta
    19681 agaaacattg aaggtgttga agaaataata agaaccaata gctagaaagg ataagtagta
    19741 ttatgagagt tgttgtacag agagttaaac atgcatctgt aaaagttgaa ggcgaattga
    19801 taggtgaaat aggtaaagga atattagtgt tagtaggatt tttagataat gatgatatga
    19861 aagtatatga ttatatgctt gataaaataa ttaacctaag aatatttgaa gatgaagatg
    19921 ataaaatgaa tctgtcagtc aaagatattg aaggtgagat aattattgtt cctaacttta
    19981 ctttgtatgg cgactgtaga aaaggacgga gacctagtta ttcagtagct gctaagccgg
    20041 ataaagctag aatgattttt gatgaattca ttaagagagc taatgaaaaa tatgatggaa
    20101 taaagcaagg tatgttccaa gctgatatga aggtagagct attaaacgat ggacctgtaa
    20161 ctttactttt agatagtgag aaagtgtttt agcatagttt taatcaaatt gatagtagga
    20221 gaaggttatt actcttagct atctttttgt aagaggagga tttataatga aagttaaaac
    20281 aatgatgtta gggattttgc agacaaatgt ttacattgtt tatgatgaag aaagtaaaga
    20341 tgcagtagtt attgacccag ctggggatga agatagaatc attagattta ttgaagagaa
    20401 taatctaaga ttaatgggta ttcttattac acatggacac tttgatcata ttggagtagt
    20461 agatgcaatc agggataatt atggtgtgcc tgtatttact agtagacaag aaggggagct
    20521 tatggctgac cctaataaaa atctatcctt gaatcttatg agaacagttg ttgcagtaga
    20581 aaatgatgaa gttgttggag ataaagatat tcttgaattt ggtgaattag agtttgactg
    20641 tatcgttgtt ccaggtcatt caccagaaag tgtatgttat tataataaag ataatgatgt
    20701 attgttttgt ggggatacat tgtttgctgg ttccataggt agaactgatt tttatgatgg
    20761 accacaaaat acattaatta atagtataaa ggataggctt atgattttac cagaagagac
    20821 aaaagtttat ccaggtcatg gttttcaaac aactattggt tatgagaaaa agacgaatat
    20881 atacatgtgt taatattaat catgtgaaaa tttaattata taagttggtt taaatgatta
    20941 cttcagtaat tgttaactta ttatacttat aaatcaagaa agatattgaa cttattataa
    21001 tgggtgtata gctgtgtaag ttcaatatat ataggagtaa gatttaatgt atttattact
    21061 aaaaggtcat gattatgaat atgaaatcaa aatgctgctt aatctatttt atcatggaga
    21121 agattatgat atagtagaag acataccctc tcaaggtgtt tctattgaaa cagtagtatg
    21181 tgaggattat tttaaagctg cttattatga aaatggtgaa attatagaaa cttcttcttt
    21241 ggacaaggag tatattaagg atttaccaaa tgaacctctc gaaagaagaa aacaatcaaa
    21301 aatattgctt aagagattac tttacaatgt ggcttcaaaa gtaacaggta taaagcagcc
    21361 ttggggtata ttgacaggta taagacctac taagatagtg tttgatttaa tagatagata
    21421 tggtgatgat gaagatagaa ttagatattg tcttgaaaat cattataaga tatctccatc
    21481 aaaagttaat ttgatgatgg aaattgtaag aagtgagatg gagatattaa gtactaacaa
    21541 ggatgatgag attaatatat atctagggat acccttttgt ccaactagat gtttgtattg
    21601 ttctttcacg tcgtatccaa tagat
//
