LOCUS       NZ_CP058561            21428 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Vallitalea guaymasensis strain Ra1766G1 chromosome, complete genome.
ACCESSION   NZ_CP058561
VERSION     NZ_CP058561.1
KEYWORDS    RefSeq.
SOURCE      Vallitalea guaymasensis
  ORGANISM  Vallitalea guaymasensis
            Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
            Vallitaleaceae; Vallitalea.
REFERENCE   1  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Vallitalea guaymasensis genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2020) Microbiologie Environnementale et
            Biotechnologie (MEB), Mediterranean Institute of Oceanography (MIO),
            UMR 7294, 163 avenue de Luminy, Marseille 13288, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. JUNE-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141425.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:20:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,859
            CDSs (total)                      :: 4,781
            Genes (coding)                    :: 4,757
            CDSs (with protein)               :: 4,757
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 7 of 24
            Pseudo Genes (incomplete)         :: 16 of 24
            Pseudo Genes (internal stop)      :: 1 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4408380
            Orig. end                         :: 4429808
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058561.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21428
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="11"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21428
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21428
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11428](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11428
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(79..92)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     gene            146..1186
                     /locus_tag="HYG85_RS18865"
                     /old_locus_tag="HYG85_18780"
     CDS             146..1186
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1118:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.5"
                     /locus_tag="HYG85_RS18865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18780"
                     /product="ABC transporter permease"
                     /protein_id="WP_212690964.1"
                     /transl_table=11
                     /translation="MENVDMKSQAVYKKPTFMEKYSSLIKYILKRLLLMIPVILIISLI
                     IFTIVEFMPGDPLNAFLNPEQLTGTTEEILQKRQFFIEKLGLDDPFLVRFFRWWGQILR
                     GEFGYSVIKNKPVKDFIGEHFMNSFRVNIYGFAIAFIIAIIVGIKSAVKRNSIFDKCWT
                     VFSIAGISLPRFFIAMLLIFIFSITLGWLPISGMSDPLGLRPEFQYYILPVSVITLALL
                     APLIKYVRNSMLEVLKQDYIRTARAKGLGEKVVIYRHAFRNALIPVVTLIGAYIPALFG
                     GSIIVEKIFVWNGIGSLIRDSYTFRDRSVLIIALTFFALLTLLGNLMQDVGYSLVDPRV
                     REGGNK"
     gene            1183..2187
                     /locus_tag="HYG85_RS18870"
                     /old_locus_tag="HYG85_18785"
     CDS             1183..2187
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1085:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.5"
                     /locus_tag="HYG85_RS18870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18785"
                     /product="ABC transporter permease"
                     /protein_id="WP_212690965.1"
                     /transl_table=11
                     /translation="MMTNKNVKGKEKILSPTRLMLLKFRANRLAMFGFLVFLAIVIVVL
                     VFTIYTKVINYDFANLSQIGEGSYTAPNSKYWFGTDKYGRDYFYRVITGGYIALQVALL
                     STLLTVGIGVVVGAISGYFGGMVDVVLMRVGEIVISFPFLALAIAVSAIFIDYPAKIRL
                     YIMICIIGLLSWPGLARMVRAQILSLKEQEFMTATKVLGISTRQQITKHLIPNVIAYVI
                     VSATITFATSIMLEASLSYLGLSVTEPVATWGGLLQRASNSVVMRNYWWLWLFPGILLF
                     LLVMSVNLIGEGLRDAVDPKSEIIKKKNVFVRLFGRFFSKPFGGAKGEQSIRG"
     gene            2108..3151
                     /locus_tag="HYG85_RS18875"
                     /old_locus_tag="HYG85_18790"
     CDS             2108..3151
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015514984.1"
                     /locus_tag="HYG85_RS18875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18790"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212690966.1"
                     /transl_table=11
                     /translation="MFSLDYLADSSVNHLEVQRVNKVLEVNNLCTYFFTDKGTVKAVNG
                     VDFIIEEGKTLGIVGESGSGKSVTAMSILNLVENPGEIVNGEIFFEGVNLVDLNMKEMR
                     KIRGNNISMIFQEPMTSLNPVLRIGKQLIEPLMLHQKLSKDEAWIKAIDLLKSVKIPTP
                     ERVINCYPHEFSGGMRQRVMIAMALACRPKLLIADEPTTALDVTIQAQIFKLMNQLKVT
                     LNTAIMFITHDLGVIAELADDVVVMYCGQVVERAPVEKIFGDKDYEHPYTGGLLKSIPK
                     LDKDVEKLEQIEGSVPHPLNLPKGCKFAPRCKYATDKCNEEMPELKKVEEDHFVRCFYP
                     EMGKDNE"
     gene            3144..4139
                     /locus_tag="HYG85_RS18880"
                     /old_locus_tag="HYG85_18795"
     CDS             3144..4139
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002605247.1"
                     /locus_tag="HYG85_RS18880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18795"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212690967.1"
                     /transl_table=11
                     /translation="MNKNIIVETQGLKLYFPTGEKDKDKKPLSVKAVDGVDLQIYEGET
                     LGLVGESGCGKSTIGRTILKLYKATEGTIKYRDKDITDWSIKQMLPLRKDMQLIFQDPY
                     SSLNPRMTVGQIIGEALVANGMYKKKSTELEEYVMEIMETCGLDSYMIHRYPHEFSGGQ
                     RQRIGIARALALNPKFVVCDEAVSALDVSIQSQIINLLDSLQKKYGMAYLFISHDLSVV
                     KHISDRIAVMYLGNFVELATKDELYNNPLHPYTKALLSAIPVTDLEIIKNKKRIVLEGD
                     IPSNVNPPSGCKFHTRCPIATDKCSKEKPQWEEVTKGRYVACHYKGADIN"
     gene            4102..4320
                     /locus_tag="HYG85_RS18885"
                     /old_locus_tag="HYG85_18800"
     CDS             4102..4320
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS18885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_18800"
                     /product="hypothetical protein"
                     /protein_id="WP_153064061.1"
                     /transl_table=11
                     /translation="MLLVIIKELISIKDNVSRGTKVRKKEENSLNGTKLERGDTTAIII
                     AALTTVLPFGLGIFLIYLIFIKILFKI"
     gene            4668..6401
                     /locus_tag="HYG85_RS18890"
                     /old_locus_tag="HYG85_18805"
     CDS             4668..6401
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="HYG85_RS18890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18805"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212690968.1"
                     /transl_table=11
                     /translation="MLKDYLRKYVKYLRPFINYEVMIFIILGLSSLISLVNPLLFKVII
                     DRVLILKEVELLNYVIGIFLFFYIINLLMSFCNGYLNLYVNQSIAKNIRNDLVNHLQKC
                     KLHILENIKVGDVVSKSIDDVSTVTGFMTDTIISIINNFTNVIITALVMFYFSWKLSLI
                     GIISVLIQTYISTRYAKKVKINQEEIREKASVHISFLKQIMSSIKIIKAYSKEEANSQN
                     YDSLLKKIIHLSYDRFLIIFKHSSFVSLVSFVSSMLIFIIAIYEIYKGNMTVGVFFVFD
                     TLVERFNQFSSALINLNINIQNVMVAFGRIESIFNMKEEDNLSLNETIEGSDIIVDNLS
                     FKYEEDSNIDVIKNLSLQFKKGSKYAIIGESGEGKSTISNLLIRLYDIEDDKGNIIIGN
                     KNIKNINIYKLRQKISVVFQEGYLINGSIKENILYGNSNVQESYFQKILELCHIQDFII
                     QLPNGIQTIIGENGFNLSSGQKQRICIARSLLRNSDIYIFDESFSNLDKKLESKIYNNI
                     LKEFQDKTIIFIIHNLDLIKGMNNICVLKEGNIEAIGSSDELMRKSETYKELLDRGKSI
                     G"
     gene            6394..6822
                     /locus_tag="HYG85_RS18895"
                     /old_locus_tag="HYG85_18810"
     CDS             6394..6822
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS18895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_18810"
                     /product="hypothetical protein"
                     /protein_id="WP_212690969.1"
                     /transl_table=11
                     /translation="MDNKKMIIAVKVLFVLCFILTCLFLIGLNMLKIQERYIVNGKFFG
                     SGEDTYFMTNILNDNSLGEVNEILSFLTYDFYLDSEYEGIIIEKSECELGLEEGDVIRY
                     KIQFQPNVNTFDPDKLYEFQVSKDEKSLLSILLEKSGL"
     gene            6973..7233
                     /locus_tag="HYG85_RS18900"
                     /old_locus_tag="HYG85_18815"
     CDS             6973..7233
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS18900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_18815"
                     /product="hypothetical protein"
                     /protein_id="WP_212690970.1"
                     /transl_table=11
                     /translation="MLPKPNIIKMPNASTNMFMGLNGCGSGYNTQVISTKATCSSDYSC
                     HPVSGDNCVDSSYSSGCGWTLGIGAGGAAVGAGVTVGIAIT"
     gene            7414..8142
                     /locus_tag="HYG85_RS18905"
                     /old_locus_tag="HYG85_18820"
     CDS             7414..8142
                     /EC_number="3.4.26.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.5"
                     /locus_tag="HYG85_RS18905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18820"
                     /product="type II CAAX prenyl endopeptidase Rce1 family
                     protein"
                     /protein_id="WP_212690971.1"
                     /sec_met_domain="Abi (E-value: 7.6e-18, bitscore: 62.9,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLFLIAAISILLLMRFNEKVYIIKDNIQWMDSIYIIFSIIGCYLI
                     SILLDLGYFNKGLVINGINLIPSYILAYYFIIPIVYMIIRQPLYFKNMWKINSKIGLFT
                     ILICLPNIITSIVRIIVGAYNYISPDNLIQNIFRFIFMAALLEELFFRGFLYNFFKNII
                     GKTSSTIITSLIFTFWHMSLVNNAFSNYSMGAIYNLIAIMVLGITNCLIIERTKSIIPC
                     IVFHAVINGTFLNLILLFVN"
     gene            8167..8469
                     /locus_tag="HYG85_RS18910"
                     /old_locus_tag="HYG85_18825"
     CDS             8167..8469
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS18910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_18825"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_113671424.1"
                     /sec_met_domain="PF05402 (E-value: 5.5e-06, bitscore: 24.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKNLVPEVKTINWKGEGDYAVVNNNFEKLLLNKSVKLVLELING
                     INTIDDINNILINEYKDTDEPHYIEEIVEESIQLLIDNNIINMKEDEIDGWLQYE"
     misc_feature    8208..8217
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.22"
                     /tool="antismash"
     gene            8447..9805
                     /locus_tag="HYG85_RS18915"
                     /old_locus_tag="HYG85_18830"
     CDS             8447..9805
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="HYG85_RS18915"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18830"
                     /product="B12-binding domain-containing radical SAM
                     protein"
                     /protein_id="WP_212690972.1"
                     /sec_met_domain="PF04055 (E-value: 2.9e-13, bitscore: 48.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGYNTNNILLINLPIQTYLQKDFSSDTQYNPSLGLISLGTWLEL
                     NGYLATVIDLCYHRMPFKEVIDNIEQLQPILIGISVYTENIDLAKLFAEKIKSVYPHVP
                     IVLGGPHPTLVPEDGMESQYVDYIIRKEGESTMLELVEAIESNEYLIKLDDIDGLVFKR
                     DGRIIKNKLRKQCTDLDIAPLVKRDLVDLSKYKEIINIFTSRGCPGRCIYCSATTLSGA
                     TYRVRNIENVFMEIVMMRALLNTKVMKIYIVDDTFTAIPDRVKKFTELMTEYDPDIYWH
                     CESRIDVMSEELLNLMSENKCIAIQYGIESASQEVLDSIRKGIDLTKARKIIDYTYKKK
                     IFLCLSFMVGHFCDTKDTMEETYLFIKEMYEKYRAEIALSFNTPFPGTWQHTHKAKLGL
                     EITADRYKQYSLLDPIVKTDNFTVNDQREIFYKSSKYLARAVKIESLKREWVK"
     gene            9802..10017
                     /locus_tag="HYG85_RS18920"
                     /old_locus_tag="HYG85_18835"
     CDS             9802..10017
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS18920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_18835"
                     /product="hypothetical protein"
                     /protein_id="WP_212690973.1"
                     /transl_table=11
                     /translation="MINKIILRTTSNLSFCGEIVTNNLLNEKGALLKTSPKSDIKIWCP
                     IDEIKTIIYPDGKKVEGEDIKHELRL"
     gene            10001..11428
                     /locus_tag="HYG85_RS18925"
                     /old_locus_tag="HYG85_18840"
     CDS             10001..11428
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Subtilosin_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="HYG85_RS18925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18840"
                     /product="PqqD family peptide modification chaperone"
                     /protein_id="WP_212690974.1"
                     /sec_met_domain="Subtilosin_rSAM_RRE (E-value: 5.9e-08,
                     bitscore: 31.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 3.6e-06, bitscore: 25.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.9e-50, bitscore:
                     170.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.7e-20, bitscore: 72.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.4e-14, bitscore: 51.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.5e-10, bitscore: 37.9,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.3e-14, bitscore:
                     50.1, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.6e-05, bitscore: 22.8,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLDYDKVYTLDNEFEIIEKDNKYLFIDYNNVNWLRTNSTGKEIL
                     NRCDGKETLQNVIQQISELYSFGTDFLKEQFSDFLKEAINKELLLKSGHSKTILEPASA
                     EYPNDVWIHVTEKCNLRCPFCYSNSTCADVEQEEVDIDAVIGFLEKIPKDYRSTVLISG
                     GEPFLFKGLPTLTKRLNELEYKNIVIITNGTVGNEIYKEVLPNIHSLQVSVDGTQAEYH
                     ERTRGKGSFDKMVKSLKLAREFNIKRLIISFTPTKYNISNLPEIPKFAYEHDIDSIHLT
                     RLMPVGRGVDNKPVIESDPDEYETNVREFMKNMERINRRIHYIRETEEFFLEEDKKRKY
                     VELSMAADQSKKVINRHKVTNCSLGCGTISISSDNNVYPCPSLQHEEYRLGNILEDNME
                     DIMQIGKEVACKYSVDNISTCKDCKMRYFCGGGCRACALGNEGNIDGEDPLCEYYMKAM
                     LEIIWNYTRPIIDKEGA"
     aSDomain        10046..10267
                     /aSDomain="Subtilosin_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a subtilosin
                     sactipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYG85_RS18925_Subtilosin_rSAM_RRE.1"
                     /evalue="3.50E-10"
                     /identifier="RREFam018.1"
                     /label="HYG85_RS18925"
                     /locus_tag="HYG85_RS18925"
                     /protein_end="89"
                     /protein_start="15"
                     /score="31.1"
                     /tool="antismash"
                     /translation="EIIEKDNKYLFIDYNNVNWLRTNSTGKEILNRCDGKETLQNVIQQ
                     ISELYSFGTDFLKEQFSDFLKEAINKELL"
     gene            11430..12770
                     /locus_tag="HYG85_RS18930"
                     /old_locus_tag="HYG85_18845"
     CDS             11430..12770
                     /NRPS_PKS="Domain: Aminotran_3 (37-381). E-value: 1.6e-78.
                     Score: 256.0. Matches aSDomain:
                     nrpspksdomains_HYG85_RS18930_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012428.5"
                     /locus_tag="HYG85_RS18930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18845"
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_212690975.1"
                     /sec_met_domain="Aminotran_3 (E-value: 3.2e-83, bitscore:
                     277.8, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLNLRNVISHDMDFKYPVWHPYSSVNKDYFSMRNFVRGEGIYL
                     FDVNNKKYIDASSGLWNIALGYGNERIISAINKQLYDLPFTSLFYYTNPIIIACANKIL
                     SFSECDMKKVFFTCSGSESIELAIKTMREYWTIRKRDDKKTIISFNNSYHGTHYGSMGV
                     SGLSRKHIAGYGPLVDDIVFFDPEIEQKDVSKNERDNEELQAIEEYIIKNHDRIAGILI
                     EPILASNGVSIITDRYIDMIQRLCIEYNILITVDEVTVGFYRTGEALYSNSLSIEPDII
                     CMAKGINNGYLPLGAVMFNEKIYSVYNQSDKLLYHGTTQGGNLASCAACIAAIEEYSRL
                     NIGENVKHINSYLMDKLSKNIINHKNVNDIWGKGCLIQIELIREKKNNSQLSIQQIGIL
                     KYELLKKGLIVSHAESGLTLLPMLIMNEEQVDELVGILEQVFSSIVF"
     aSDomain        11541..12572
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_HYG85_RS18930_Aminotran_3.1"
                     /evalue="1.60E-78"
                     /label="HYG85_RS18930_Aminotran_3.1"
                     /locus_tag="HYG85_RS18930"
                     /protein_end="381"
                     /protein_start="37"
                     /score="256.0"
                     /tool="antismash"
                     /translation="VRGEGIYLFDVNNKKYIDASSGLWNIALGYGNERIISAINKQLYD
                     LPFTSLFYYTNPIIIACANKILSFSECDMKKVFFTCSGSESIELAIKTMREYWTIRKRD
                     DKKTIISFNNSYHGTHYGSMGVSGLSRKHIAGYGPLVDDIVFFDPEIEQKDVSKNERDN
                     EELQAIEEYIIKNHDRIAGILIEPILASNGVSIITDRYIDMIQRLCIEYNILITVDEVT
                     VGFYRTGEALYSNSLSIEPDIICMAKGINNGYLPLGAVMFNEKIYSVYNQSDKLLYHGT
                     TQGGNLASCAACIAAIEEYSRLNIGENVKHINSYLMDKLSKNIINHKNVNDIWGKGCLI
                     QIEL"
     gene            12787..15147
                     /locus_tag="HYG85_RS18935"
                     /old_locus_tag="HYG85_18850"
     CDS             12787..15147
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="HYG85_RS18935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18850"
                     /product="radical SAM protein"
                     /protein_id="WP_212690976.1"
                     /transl_table=11
                     /translation="MLDAVLIYMNVVNGYITGAEYQLDSAYVMSYLRKNEVEVIQYINK
                     DINNYHELINDLFNYKTDAYIFYINEYNYYISKVIINGLKSCIKDNRIIAFGPVSKYIS
                     HNLLDEVMIDICVLQEEPMTIYNLINSYSLDHIDNIIYRKGTEIVEKGIRYYDYTLDDI
                     GFPYSSGSVPIEEVENVGLITSKGCYGNCAFCSYTKNRYLTHSIEGIIDELKYIEKYFA
                     YSSLKINFYDDCFSISNNRTKELCKEIIKNKIKYTYWCCTRADLLSEELIDLMSEADFK
                     NIVIGLETASNKVMSKLGKAVGSENSSQFIEKVRKSYKKCEEVGINPYISINFGLPFEK
                     LEDAFRTIEYVKDKKMDNISVCFMTSFPGSRIFENSRLYDTHKDMSPTVLPYRTYYHNY
                     DMGKIHNLLKQKNILNDIYIEQSTRKSKIVKDILYYYSGIPFSNRYSKFNNIFVKDDAN
                     DYLDFIDNYININGRIIHNNNKLSLSKDYLFCDDRKNIKYCIKEYDHTLEAAYKSDKYI
                     PSIISTRTKDNTTNIQIDNLYDSKKLSITTRSLNSLQDLIELENNAAEVMNKGYFTIND
                     IKQGIIQNSCMFSGICTLSQFNRVTLSDEKVNLCINHGHVGSTTDTTNQLVDNLSKQME
                     QNSSAECSNCKFYSKCSKCTFLPHFLNRKMFCEHIRCNPKLWHYLRMKNILYHYHTFNL
                     FNIEGEDKIRFIICKDCNSGDSYSFKDEVVMFEYDYISIIYNLESNTMIYCTKDEQDTA
                     KYLMGLKEDISFSNERYIDIILKLEKNNMLVER"
     gene            15154..15933
                     /locus_tag="HYG85_RS18940"
                     /old_locus_tag="HYG85_18855"
     CDS             15154..15933
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.5"
                     /locus_tag="HYG85_RS18940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18855"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_212690977.1"
                     /transl_table=11
                     /translation="MEYFGFCKEINEMSLSDIYEEEIYSGHFAKFYDTNVNDIFDVPLY
                     EKLAREYGNHIMEFACGSGRILVELLKRGYDAAGLDISQDMLEILEEKCSKLDVKPTLV
                     CDDMLRHVSSSKYDIIILARITICLLEDDETRIKLFNNVYNNLRDGGVFVFNYLDCPKE
                     IELGEKRPTFLFDKDKKGYAIISEKILEDRSIVNIYSETNIDDKTKRYITSTSKYLLNN
                     EMISNIIDQTAFKHEKTYTLNAVNYETGKMKFVVLKK"
     gene            15947..16594
                     /locus_tag="HYG85_RS18945"
                     /old_locus_tag="HYG85_18860"
     CDS             15947..16594
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HYG85_RS18945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18860"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_212690978.1"
                     /transl_table=11
                     /translation="MIKVEHLSKQFVKKKRRINVINDFNYEFQSGKLYLIKGESGKGKT
                     TLLTLLAFLQKEDGGKIIFNDIIVSNLKQEEKCNLRRKEIGIVFQDYNLFDNLTVMDNV
                     VIVDVLKNKINKEEIYNKAKDIIGILGLEDRINHYPYELSGGEQQRVGIARAILKNPSI
                     LICDEPVSNLDKDNAVNIVEFIDGYCHNKNKIVIVASHDDYFDDCADYVINL"
     gene            16608..17771
                     /locus_tag="HYG85_RS18950"
                     /old_locus_tag="HYG85_18865"
     CDS             16608..17771
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024116.5"
                     /locus_tag="HYG85_RS18950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18865"
                     /product="ABC transporter permease"
                     /protein_id="WP_212690979.1"
                     /transl_table=11
                     /translation="MSKKIFMDIYFEKKRFLIIFFVFLVLLLTYGGVQYQIIKQQTKSV
                     LTPDINLKGKSSQDGVFHYWLYHDVDGLSDALKELYGKDMSVYKTITRNLYYIDDRLTF
                     QSIYYVITGVEDKFFQQELKNSVAKGRLPRSGEKEVVIGPYSAKEYNLGIGDLVNLSVT
                     LEKDIADVEPNQYKVVGILDDNVEQFKSSIMLSIDTYETLNDTKVIENEVLVYFKNNDS
                     INIYKDTISEFTNMIGEYNVGSTSSNFKSNNNKHSNIIINIVMMLVSNFIIVFLLISYL
                     MKGLSKKIGLLKALGLSNRYINKIFVGGLSIVVGGVFVISILLVSLILNAMNNSATSFL
                     GYEMNIYSMDTGVIIYMAGLCLFIIIIKYVLIKLKTYRIYPMEAMVK"
     gene            17811..18215
                     /locus_tag="HYG85_RS18955"
                     /old_locus_tag="HYG85_18870"
     CDS             17811..18215
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS18955"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_18870"
                     /product="hypothetical protein"
                     /protein_id="WP_212690980.1"
                     /transl_table=11
                     /translation="MKRDTKLLLVLTVICISFIFVFNLMNRQHTSKAAFEEAVDFGKYS
                     DSIFIPFDVKKDSILKFECSASVEQGNITIQIINKGNEILYTKSGSNYEDSVDVKIPEG
                     LWYCNIIINNSNSPDDMAEKGTYSVYGKLK"
     gene            18495..19652
                     /locus_tag="HYG85_RS18960"
                     /old_locus_tag="HYG85_18875"
     CDS             18495..19652
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012200077.1"
                     /locus_tag="HYG85_RS18960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18875"
                     /product="DUF3798 domain-containing protein"
                     /protein_id="WP_212690981.1"
                     /transl_table=11
                     /translation="MKQLKRLFSIFLVLALTVSMFVGCGKKSTGDWKIGIITGTVAQNE
                     EEYRAAQRTKEVFMERYGEDKVILQTYPEKFMDEQETVIANIAGIAADPKVKALVICQA
                     VPGTSAAIDKVLETRDDLLIIAATSGEDPNMIADRADLCFQMDEVGMGTAIVEQIKKQG
                     AETLVHYSFPRHMSYALLAARRDLLKENCKKEGIKFVDATAPDPTGDAGISGAQQFILE
                     DVPKKIKQYGEDTAFFSTNCSMQPPLIKSILQQHGIYPQPCCPSPYHGFPSALQIEIPE
                     DKKGDANYVVEQIRRINAENNMTGRMSTWPVPVNMMFIEAGAEYASQWIEGKWGDKIDN
                     EKLKECFVDYTSNYGDDIDINVTLLEENGKKFDNYFLVLIDYIDL"
     gene            19771..21369
                     /locus_tag="HYG85_RS18965"
                     /old_locus_tag="HYG85_18880"
     CDS             19771..21369
                     /EC_number="7.5.2.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008718892.1"
                     /locus_tag="HYG85_RS18965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_18880"
                     /product="sugar ABC transporter ATP-binding protein"
                     /protein_id="WP_212690982.1"
                     /transl_table=11
                     /translation="MECDYLLEMKNISKNYSGNQVLKDVELKVKPGEIHCLVGENGAGK
                     STLMNILFGMGVIHNTGGFEGEVYFEGEKVDVKSPKEAMQLGIGMVHQEFMLIPEFTIT
                     ENIKLNREILKDNLVSRALGEKLKTVDFKRMNKDARKALDTLEINIDEWIKVAGLPVGH
                     MQFIEIAREIDKQNVKLLVFDEPTAVLAESEAKNLLTAMKKIANSGIAILFITHRLDEV
                     ISIADNVTILRDGVRVCNKRAEETDVGELAELMVGRKIDIQNKQASKNISQEIILDIKN
                     LYVDMPGERVKGIDLQIRKGEIFGIGGLAGQGKIGLANGIMGLYPSKGEVLYNGEELNL
                     NDTKNTLKKGFAFVSENRKNVGLILDESIELNMIFTALNIKEQFLINLGLFKLKNFTKI
                     KKYSMKRIKELDIRCTSSRQHVGRLSGGNQQKVCIARALTQEPDVLFVSEPTRGIDIGA
                     KKLVLDLLLKLNEELGMTIIMTSSELAEVRSIADRIAIISEGKLAGILKPSDTNKKFGL
                     LMSGIPLNKIMEEEA"
ORIGIN
        1 taatgcattt tgggattggg tacctgctct tattaagtgt acagttaaat aattacagtt
       61 tcaaagtaat tatttaattc actcatggtt atatatttca tagtccctat ccacaagata
      121 gggactatta gaaaaggatg gtaagatgga aaatgtagat atgaaatccc aagcagttta
      181 taaaaaacca actttcatgg aaaaatactc atctcttatc aagtatatac ttaaaagatt
      241 attattgatg atacctgtaa tacttataat atcattgatt atatttacaa tagtcgaatt
      301 catgcctggt gatcctttga atgctttctt gaatcctgaa cagcttacag gtacaactga
      361 ggaaatatta cagaagcgac aattctttat agagaaactt ggacttgatg acccattctt
      421 agtaagattc tttaggtggt ggggacagat tttaagaggt gaattcggtt actctgtcat
      481 caagaataaa ccagtaaaag actttatcgg agaacatttc atgaattcat ttagagtcaa
      541 tatatatggt ttcgcaattg ccttcatcat tgctattatt gtaggtataa aatcagctgt
      601 taagagaaac tccatattcg ataaatgttg gactgtgttt tctatagcag gaatatcatt
      661 accaagattt tttatagcta tgttattgat ttttatattc tccataactc ttggatggtt
      721 gccaatatca ggaatgagtg atcctctagg attaagacct gaattccaat actatatttt
      781 accagtatca gttatcactt tagccttact tgcacccctg ataaaatatg taagaaattc
      841 aatgttggag gtattgaaac aagattatat aagaacagca agagcaaaag ggttaggaga
      901 aaaagttgta atctacagac acgccttcag gaatgcgctt atacctgttg ttaccttgat
      961 tggagcttat atcccagcat tatttggtgg ttccatcatt gttgaaaaga tattcgtgtg
     1021 gaatggtata ggaagtttaa taagagattc atatactttc agagatagaa gtgtacttat
     1081 aatagctctg actttcttcg ctctgttgac attgttagga aatcttatgc aggatgtggg
     1141 ttattcacta gttgacccta gagtcagaga aggaggtaat aaatgatgac aaacaagaat
     1201 gtaaaaggaa aagaaaaaat attatctcca actaggttga tgttattgaa atttcgagcc
     1261 aataggttag caatgtttgg ttttttggta tttttagcca ttgttattgt tgtattagtt
     1321 tttacaatat atacaaaagt aatcaattat gattttgcta atctaagtca gattggtgaa
     1381 ggttcttata cagctcctaa tagtaaatat tggtttggta ctgataaata tggaagagat
     1441 tatttttata gggttataac tggaggatac atagctttac aagtagcatt attatctact
     1501 ttattaactg ttggcattgg tgtagtcgta ggtgccatct ctggatattt tggtggtatg
     1561 gtagatgttg ttttaatgcg tgtcggagaa atagtcattt cttttccgtt tttggcatta
     1621 gcaattgctg taagtgcaat ttttattgat tatccagcta agatcagact atatataatg
     1681 atatgtatca ttgggctgtt gagctggcct gggttggcta ggatggttag agcccagatt
     1741 ttatcactaa aagaacagga attcatgact gccacaaaag tactaggaat ttcaacacgc
     1801 cagcaaataa ctaaacatct gattcccaat gttattgctt atgtgatcgt gtcagcaact
     1861 ataacttttg caacttccat aatgttagag gcttccttat cttatttagg actttcagtc
     1921 actgagcctg tggcaacatg gggaggtctt cttcaaagag catccaattc agtagtcatg
     1981 agaaattatt ggtggttgtg gctattccct ggaatattac tatttctact tgtaatgagt
     2041 gtgaacctta ttggtgaagg acttagagat gcagttgacc ctaaatcaga aataatcaaa
     2101 aagaaaaatg ttttcgttag actatttggc agattcttca gtaaaccatt tggaggtgca
     2161 aagggtgaac aaagtattag aggttaataa tctatgtaca tattttttta cagataaagg
     2221 aactgtgaaa gcagtaaatg gtgtggattt tataatagaa gaaggtaaaa cacttggtat
     2281 agttggagaa tctggcagtg gtaaatcagt aacagcaatg agtattttga acctagtaga
     2341 gaatccaggt gaaatcgtaa atggggaaat attttttgaa ggggttaatt tggttgatct
     2401 taatatgaaa gaaatgagga aaataagagg aaataatata tctatgatat tccaagaacc
     2461 aatgacttct ctaaatcctg tgttaagaat tggaaagcaa ctgattgaac cacttatgct
     2521 acatcaaaaa ttatcaaaag atgaagcatg gataaaggct atagaccttc ttaaaagtgt
     2581 taagatacct acacctgaaa gagtaatcaa ctgctatcca catgaatttt caggaggcat
     2641 gcgtcaaaga gtcatgattg caatggcatt agcctgtaga ccaaaattac ttatcgctga
     2701 tgaaccaaca actgctttgg atgtaacaat tcaagctcag atattcaagc ttatgaatca
     2761 actgaaagtc actctaaata ccgctataat gtttataacc catgatttag gtgtaatagc
     2821 tgaattagca gatgatgttg tggtcatgta ttgtggtcaa gttgttgaaa gggctccagt
     2881 tgaaaagata tttggcgata aggattatga acatccttat acaggcggtt tattgaaatc
     2941 tattccgaaa cttgacaagg atgtagaaaa acttgagcag atagaaggca gtgttcctca
     3001 cccacttaac ttgccaaaag gatgtaaatt tgctccaaga tgcaagtatg caaccgataa
     3061 atgcaatgaa gaaatgccag aattaaaaaa ggtggaagaa gatcattttg taagatgttt
     3121 ctatccagaa atggggaagg ataatgaata aaaatataat cgtagaaact caaggattaa
     3181 aattatattt tccaactggg gaaaaagata aggataaaaa accactatca gttaaagctg
     3241 ttgatggagt ggatttacag atatatgaag gggagacatt aggattagta ggagaatctg
     3301 gttgtgggaa atccacaata ggaagaacca tacttaaatt atacaaagca actgaaggta
     3361 caattaaata tagagataaa gatataactg attggtctat taagcagatg ttgccacttc
     3421 ggaaagatat gcagctgatt tttcaggatc cttattcatc gttaaatcct agaatgacag
     3481 ttggacagat tattggagag gcattagttg ctaatggaat gtataagaaa aaatccactg
     3541 aattagagga atatgttatg gaaatcatgg agacatgtgg acttgatagt tatatgattc
     3601 acaggtatcc tcatgaattc tctggaggac agagacaaag aattggtatc gctagagcac
     3661 ttgcattaaa tccaaaattt gttgtatgtg atgaggcagt atctgctctt gatgtttcta
     3721 tacaatctca gatcatcaat ttattagata gtctacagaa gaaatatgga atggcttatt
     3781 tattcatatc tcatgactta agtgtagtaa aacatattag tgatagaatt gctgtcatgt
     3841 atcttggcaa tttcgttgaa ttagctacta aggatgaatt atataacaat cctttacatc
     3901 cttatacgaa agctctacta tccgcaatac ctgtcactga tttggaaata ataaagaata
     3961 aaaagagaat agtattagaa ggtgacatac catctaatgt taatccacca tcagggtgta
     4021 agtttcacac acgatgtcct attgccactg acaaatgttc aaaagagaaa ccacaatggg
     4081 aagaagttac aaaggggaga tatgttgctt gtcattataa aggagctgat atcaattaag
     4141 gataatgttt caaggggtac taaagtaaga aaaaaagaag agaatagtct taatggaacc
     4201 aaactggaga gaggtgatac taccgctata atcatagcag cacttactac agttcttcca
     4261 tttggattag gaatcttttt aatatatcta attttcataa aaattctctt taaaatataa
     4321 tatttgggtt cttgtattaa ttaatataat gcaagaactt gttttttagt ttatataata
     4381 aacctagaaa actcaatatt gcaaaaaaat cataaaaagt atataaaaat acataaattt
     4441 atcaaaatat acaataaata atccttgtat tattttgaaa aataaaatat aataaacata
     4501 taagaaaatt tagaatataa tctgtttcca ttaacatctc tgggctttgc tgatataaat
     4561 tccaaaatga acaatctatt ttaataataa taaaatatta aattataata taagtataca
     4621 ttatttataa taatgaaagt taaaataatg aatggagctg tttacatatg ctaaaagatt
     4681 atctaaggaa atatgtcaaa tatctaagac catttataaa ttatgaagtt atgattttta
     4741 ttattctagg gttaagttca ttgatatctt tagtgaatcc actattattc aaagttatca
     4801 tagatagagt tttaatttta aaagaagttg agttattaaa ttatgtaata ggcatattct
     4861 tattctttta tataattaat cttttgatgt cattttgtaa tggttatctc aatttatatg
     4921 taaatcaatc catagctaaa aatattagaa atgatttagt gaatcacctg caaaaatgca
     4981 aactacatat tttggaaaat atcaaagtag gtgatgtagt aagtaaaagc attgatgatg
     5041 ttagtacagt gactggattc atgacggata ctatcatttc tataataaat aattttacga
     5101 atgttataat tacagctctt gtcatgttct atttcagctg gaaattatcg ttgataggta
     5161 taatctcagt tcttatccag acatatatat caacaagata tgctaaaaaa gttaaaatca
     5221 atcaagaaga gattagagaa aaagcgtctg tacatattag ttttctaaaa caaataatgt
     5281 ctagtataaa aataattaag gcttacagta aagaagaagc caattcccag aattacgata
     5341 gtttattaaa aaaaattatt catctaagtt atgataggtt cttaataatt tttaaacata
     5401 gcagttttgt atccctagtg tcttttgtaa gctctatgct cattttcatt attgctatat
     5461 atgagatata taagggaaat atgaccgtag gggtattctt tgtttttgat actttggttg
     5521 aacgattcaa tcaattttct agtgcactaa taaatctgaa tattaatata caaaacgtca
     5581 tggtggcatt tggtaggata gaatctattt tcaatatgaa ggaagaggac aacctatcat
     5641 taaatgaaac catagaaggt tctgatatca ttgtggacaa ccttagtttc aaatatgaag
     5701 aagatagtaa tattgatgta ataaagaacc tttcattaca atttaaaaaa ggtagtaaat
     5761 atgcaataat cggtgaaagt ggagaaggga aatcaaccat atccaattta ctaatacgtt
     5821 tgtacgacat tgaagatgac aaaggaaata tcataatagg aaataagaac ataaaaaata
     5881 ttaatattta taaactcagg caaaagatca gcgtagtatt tcaagaaggt tatttgataa
     5941 atggcagtat caaagaaaac atattatatg gaaacagtaa tgtgcaagaa agttattttc
     6001 agaaaatatt ggagttatgt catatacaag attttatcat tcaattgccc aatggaatac
     6061 aaactataat tggagaaaat ggattcaact tatcaagcgg acagaaacaa agaatatgta
     6121 tagcaagaag tcttctcaga aattctgata tatacatttt tgatgaatca ttttctaatc
     6181 ttgataaaaa attagaaagt aagatataca ataatatatt aaaagaattc caagataaaa
     6241 caataatatt tataattcat aacttggact tgataaaagg aatgaataac atctgtgtat
     6301 tgaaagaagg taatattgaa gctattggaa gtagtgatga gcttatgaga aagtcagaga
     6361 catacaagga attattggat agggggaaaa gcattggata ataaaaaaat gattatagca
     6421 gttaaagtat tgtttgtact ttgttttata ctaacctgcc ttttcttgat aggtctgaat
     6481 atgctgaaaa tacaagagag atacattgtt aatggtaaat tctttggaag cggtgaagat
     6541 acatatttta tgactaatat ccttaacgat aacagtttag gagaagttaa tgagatactt
     6601 tcatttctga catatgattt ttatttggat agtgaatatg aagggataat cattgaaaaa
     6661 agtgaatgtg agcttggtct tgaagaagga gatgttatta gatataagat acagtttcaa
     6721 ccaaatgtga atacatttga tccagacaaa ttatatgaat ttcaagtgag taaggatgaa
     6781 aaaagtctgc tgtcaatact acttgaaaaa tctggtctat aaaataatag ttctattcat
     6841 tgctggctaa tccttaaata taaattaaga ttagttaata aacatagttt cgtaatatta
     6901 tctttttaat agtgtacata tatattcatt tgataatctt atgaaattat gtaaggaagg
     6961 aggtgcagta atatgttacc aaaacctaac ataatcaaaa tgcctaatgc ttctacaaat
     7021 atgttcatgg gtttgaatgg atgcggtagt ggatacaata ctcaagtaat tagtactaaa
     7081 gctacttgta gtagtgacta ttcatgtcat cctgtatcag gtgataactg tgtagattca
     7141 agctatagtt caggatgtgg atggacattg ggaatcggag caggtggtgc tgctgtagga
     7201 gcaggtgtta cagttggtat tgcaataaca taatgattag ctgattatac ttactctcag
     7261 gatgaatcat atcctgagag taatgtaaaa aactttttca agaatacgag gtgatgactt
     7321 atacaaaaag ctatcaaact aataaaaact aaagatgatt atatctatat tatactatat
     7381 attattccat ttttttatgt tgataaatat ggtttgctgt tcttaattgc agcaatcagt
     7441 atattattat tgatgagatt caatgaaaaa gtatacataa taaaagataa catacaatgg
     7501 atggatagca tatatataat atttagcata ataggatgtt atcttatttc aattttactt
     7561 gacttagggt attttaataa aggattagtc ataaatggga ttaatctaat accatcatat
     7621 atacttgctt attattttat aatacctatc gtttacatga taataagaca accattgtat
     7681 tttaaaaata tgtggaagat caattctaag ataggtctat ttacaatact tatatgttta
     7741 cccaatatta taactagtat agtaagaatt attgttggtg cctataatta tatttcacct
     7801 gataatctca ttcagaatat atttcgattt atttttatgg cagctttatt ggaagaattg
     7861 ttttttagag gattcttata caattttttt aagaatataa tcggtaagac tagttctaca
     7921 atcataactt cacttatatt cacattttgg catatgtcac tagttaataa tgcgtttagc
     7981 aattattcca tgggagcaat ctataatcta attgctatca tggttttagg aataactaat
     8041 tgtttgataa tagaaagaac taaaagtatt atcccatgta ttgtttttca tgcagtcata
     8101 aatgggacat tcctaaattt gatattacta tttgtaaatt aatggattct tggataggag
     8161 gatattatgg ataagaattt ggtaccagaa gtaaaaacaa tcaattggaa gggggagggg
     8221 gattatgcgg tagtcaataa caattttgaa aaattacttc tcaataaatc tgtaaaactt
     8281 gtgcttgaat taatcaatgg tataaatact attgatgata tcaataatat tttgataaat
     8341 gaatataaag atactgacga accacattat attgaagaaa tagttgagga atcaatacaa
     8401 ttattgattg acaataatat tattaatatg aaagaggatg aaatagatgg gtggttacaa
     8461 tacgaataac attctactga ttaatctacc aattcaaact tatctacaaa aagatttttc
     8521 tagtgataca caatataatc catctttagg tctgatttca cttggaacat ggctggaact
     8581 taatggttac ttagcaactg taattgatct atgttatcat agaatgcctt tcaaagaggt
     8641 aatagacaat attgaacagc tacagccaat tttaattggt atttcggtgt acacagaaaa
     8701 tattgattta gcaaaactat ttgctgaaaa aataaaatcc gtttatcccc atgtaccaat
     8761 tgtattaggt ggacctcatc ccacacttgt accagaagat ggcatggaat ctcaatatgt
     8821 tgattatatt attagaaaag agggggaatc aaccatgctt gaattggttg aagccataga
     8881 aagcaatgag tatctcataa agctggatga tatagacgga ttagttttta aaagagatgg
     8941 aaggattatt aagaataagc ttagaaaaca gtgtacagat ctggatattg ccccactagt
     9001 aaaaagagat ttggtagatc tatcaaaata taaagaaata ataaacatat ttacgagcag
     9061 aggatgtcca ggtagatgca tttattgttc agcaactaca ttatctggag ctacatacag
     9121 agtaagaaac atagaaaacg tatttatgga aatagttatg atgcgagcac tattaaatac
     9181 aaaagtaatg aaaatatata ttgttgatga tacattcacg gctattcctg atagagttaa
     9241 aaaatttact gaactaatga ctgaatatga ccctgacatc tattggcatt gtgaatcaag
     9301 aatagacgtg atgtcagaag aattactcaa tctcatgtca gaaaataaat gtatagctat
     9361 acaatatggt attgaaagtg ccagtcaaga agttttggat agcattagaa aaggaataga
     9421 tcttactaaa gcacggaaaa taattgatta cacttacaag aaaaagatat tcctttgtct
     9481 atctttcatg gtaggtcatt tctgtgatac caaagacact atggaagaaa catatttatt
     9541 tataaaagag atgtacgaaa aatatagagc cgaaattgca ctgtcattta atactccttt
     9601 tcctggaacg tggcagcata cccataaagc caaacttgga ttagaaataa ctgctgacag
     9661 atacaaacaa tattctttat tggatcctat tgttaaaact gataacttta ctgttaacga
     9721 ccaaagggaa atattctata aatcatctaa atatctagct agagctgtaa aaatagaaag
     9781 tttgaaaaga gagtgggtaa aatgataaat aaaataattc taagaactac atccaacttg
     9841 agtttttgtg gagaaatagt tactaataac ctgttaaatg aaaagggagc attattgaag
     9901 accagcccaa aatcagatat caagatatgg tgtcccattg atgaaataaa gactatcata
     9961 tatccagatg gaaaaaaagt tgaaggggag gatataaaac atgaacttag attatgataa
    10021 agtctataca ttggataatg agtttgaaat aatagaaaaa gataataaat atttgtttat
    10081 tgattataat aatgtcaatt ggcttagaac caattcaact ggaaaagaaa tattgaatag
    10141 atgcgatgga aaagaaacct tacaaaacgt tatacagcaa atatcagaat tatattcttt
    10201 tggaactgat tttctaaaag aacaattcag cgatttctta aaagaagcta tcaataaaga
    10261 attgttattg aaatcaggtc attccaagac tattttggaa ccagcttccg cagagtatcc
    10321 taatgatgta tggatacatg ttacagaaaa atgtaatcta agatgtccct tttgttattc
    10381 caattcaaca tgtgctgatg tggagcaaga agaggtggat attgatgctg taataggttt
    10441 tttagaaaaa ataccgaaag attatcgtag tacagtttta ataagtggtg gagaaccatt
    10501 tctatttaaa gggttaccaa cattgacaaa aagattgaat gaactagaat acaagaatat
    10561 tgtaataata actaatggta ctgttggtaa tgaaatatat aaggaagtct tacctaatat
    10621 ccattcgtta caagtatctg ttgatggtac ccaagcagaa tatcatgaaa gaacaagagg
    10681 taaaggttcc tttgataaga tggtaaaaag tctcaaatta gctagagaat ttaacattaa
    10741 gagattgatt atttcattca cacctactaa atataatata agtaatctgc cagagatacc
    10801 aaagtttgca tatgaacatg atatagatag tattcatctg actagattaa tgcctgtcgg
    10861 cagaggggta gacaacaaac cagtcattga atcagatcct gatgaatatg aaacaaatgt
    10921 aagagaattc atgaaaaaca tggaaagaat caatagacgt attcattata ttagggagac
    10981 agaagagttt ttcctagaag aggataagaa gagaaaatat gttgaattat ccatggcagc
    11041 ggatcaatca aaaaaagtca ttaataggca taaagtcacc aattgtagtc taggatgcgg
    11101 tactataagt ataagcagtg acaataatgt gtatccatgt ccttctcttc aacatgaaga
    11161 atataggtta ggaaatatat tggaagataa tatggaagat attatgcaaa taggtaaaga
    11221 agtagcatgt aaatactctg tagacaatat atcaacctgt aaagattgta aaatgagata
    11281 tttctgtggt ggaggttgta gagcttgtgc tcttggtaat gaaggtaata ttgatggaga
    11341 agatcctttg tgtgaatatt atatgaaagc tatgcttgag ataatatgga actatacaag
    11401 acctatcatt gataaagagg gggcataaca tgaacaatct aaatctaagg aatgtcatat
    11461 ctcatgatat ggatttcaag tatcctgtat ggcaccctta ttcatcagtc aataaagatt
    11521 acttcagtat gcgtaatttt gttcgcggtg aaggtatcta tctatttgat gtaaacaata
    11581 aaaaatatat tgatgcatca agtggtttgt ggaatatcgc cttaggttat ggaaatgaga
    11641 gaataatatc agcaataaat aaacagttat atgacttacc atttacttca ctcttctatt
    11701 atactaatcc aataataatt gcttgtgcta ataagatact atcctttagt gaatgtgata
    11761 tgaagaaggt attttttaca tgttcaggtt ctgaaagtat agaactggct attaaaacta
    11821 tgagggaata ttggactatc agaaaacgtg atgacaagaa gacaataatc agtttcaata
    11881 attcatatca tggtacacat tatggaagta tgggtgtaag tggtttaagc aggaaacata
    11941 tagctggata tggtccatta gtagatgata ttgtattttt tgaccctgag atagaacaga
    12001 aagatgtatc taaaaatgag agagataatg aggaattaca ggctatagaa gaatatatca
    12061 ttaagaatca tgatagaata gctggtattt tgattgagcc tattcttgct tctaatggtg
    12121 tatctattat tactgacaga tatattgata tgatacagag attgtgtata gaatataata
    12181 tcttgataac agtagatgaa gtaacagtag ggttctatag aactggagaa gcattatata
    12241 gtaatagcct tagtattgaa ccagatataa tttgtatggc taagggaatc aacaatgggt
    12301 atcttccttt gggtgcagtt atgtttaatg aaaagatata ttccgtatat aatcaatctg
    12361 ataaattatt atatcatgga actactcagg gaggtaacct agcatcatgt gcggcatgta
    12421 tagctgccat agaagagtat tcaagactta atattggaga gaatgtcaaa catattaatt
    12481 catatctcat ggataagcta agtaaaaaca tcataaatca taaaaatgtc aatgatatat
    12541 ggggcaaagg ctgtcttata caaatagagc ttataagaga aaagaagaat aatagtcagc
    12601 tttctataca acagataggg atattgaagt atgaattatt gaagaaaggt ctaatagtat
    12661 cacatgctga gtcaggattg acattattgc ctatgttgat tatgaatgaa gaacaggtag
    12721 atgaattagt aggtattctt gagcaggtat tttctagtat agtattttga ttggggtttt
    12781 gcagagatgt tggatgcagt attaatctat atgaatgtag tcaatggata tattacagga
    12841 gcagaatatc agcttgattc tgcatatgtc atgtcttatt tacggaagaa tgaggttgaa
    12901 gttattcaat atataaataa agatattaat aattaccatg agttgattaa tgacttgttc
    12961 aattataaaa cagatgcata cattttttat attaatgaat acaattatta tatttcaaaa
    13021 gtcatcatca atggattgaa atcttgtata aaagataata ggataattgc ttttggacca
    13081 gtaagtaaat atataagtca caaccttcta gatgaagtca tgattgatat atgcgtctta
    13141 caagaagaac caatgaccat ttataatctt atcaacagtt atagtttaga tcatatagac
    13201 aacattattt acagaaaagg aactgagatt gttgaaaagg gtattagata ttatgattat
    13261 accctagatg atattggatt tccctatagc agtggttctg ttccaataga agaagtggag
    13321 aacgtaggat tgattacatc aaaaggatgt tacggtaatt gtgctttttg ttcttatacg
    13381 aagaataggt atttaaccca tagcattgaa ggcatcattg atgaattgaa atatatcgaa
    13441 aaatactttg cctatagcag tcttaaaatc aatttttatg atgattgctt ttccataagc
    13501 aataatagaa ccaaagaatt atgcaaagag ataatcaaaa acaaaataaa atatacatat
    13561 tggtgttgta caagagcaga tttattatct gaagaattaa ttgatctaat gagtgaagcg
    13621 gattttaaaa atattgtgat tggtcttgaa acagcatcca acaaggttat gtctaagctt
    13681 ggtaaggctg taggtagtga gaattcatcc caattcattg aaaaggtaag aaaatcttat
    13741 aaaaagtgtg aggaggtagg aattaatcca tatataagta ttaactttgg attgcctttt
    13801 gaaaagttag aagatgcatt taggactata gagtatgtga aagataaaaa gatggacaat
    13861 ataagcgtat gtttcatgac aagttttcct ggcagcagga tctttgaaaa tagtagatta
    13921 tatgataccc acaaggatat gtcacccaca gtattacctt atagaactta ttatcataat
    13981 tatgatatgg gtaaaattca taatctgctg aaacagaaaa atatacttaa tgatatttat
    14041 attgagcagt caactagaaa aagcaaaata gtcaaagata tcctatatta ttattcagga
    14101 atacctttta gtaacagata tagcaagttt aacaatatat ttgtaaaaga tgatgccaat
    14161 gactatttgg attttattga taattatatt aatatcaatg gaagaattat tcacaataat
    14221 aataagcttt cattaagtaa ggattatctt ttctgtgatg atagaaaaaa tataaaatac
    14281 tgtatcaagg agtatgacca tactctagaa gcagcctata aatcagataa gtatatacca
    14341 tcaataatca gtactagaac caaagacaat actactaata tacaaataga taacttatac
    14401 gatagtaaaa agcttagtat cacaacaaga agtttaaata gcctacaaga tttgatagaa
    14461 ctagaaaaca atgctgcaga agtcatgaat aaaggttact tcacaattaa tgatattaag
    14521 caagggatta ttcaaaattc atgcatgttc agtggaatct gtaccttaag tcagtttaat
    14581 agagtaactt tgtcagatga aaaggttaat ctttgtatta atcatggaca tgtaggctca
    14641 actactgata ctaccaatca attggtagat aacttatcaa aacaaatgga acaaaacagt
    14701 agtgctgagt gtagtaactg taaattttat agtaaatgtt ctaaatgtac atttttacca
    14761 catttcctga accgtaaaat gttttgtgaa catattagat gtaatcctaa gctttggcac
    14821 tatcttagaa tgaaaaacat attgtatcac tatcacacct ttaatctatt taatattgaa
    14881 ggtgaggata agataagatt cattatatgc aaagattgta actccggaga ttcatattcc
    14941 ttcaaggatg aggtagtgat gtttgagtat gactatatat ccattatcta caacttagag
    15001 agtaatacca tgatatattg tacaaaagat gaacaagata cagctaagta cttaatggga
    15061 ttgaaggagg atatttcgtt tagtaatgag cgttatatag atataatact gaaattagaa
    15121 aagaataata tgctggttga gaggtgaata taattggaat actttggatt ctgtaaagaa
    15181 ataaatgaga tgagtttatc tgatatatat gaagaggaaa tatattctgg acattttgcc
    15241 aagttctatg atactaatgt aaatgatata tttgatgtac cgttatatga gaagctggca
    15301 agggaatatg gtaatcatat tatggagttt gcatgtggca gtggtagaat tctagtggaa
    15361 ctattgaaaa gaggatatga tgctgctggc ttggatatat cacaagatat gctggagata
    15421 ttagaagaga aatgttctaa gttggatgta aaacctactc ttgtatgtga tgacatgctt
    15481 agacatgttt catcatccaa atatgatatt attattctag caaggattac tatatgttta
    15541 ttggaagatg atgagacaag aataaaatta ttcaataatg tctacaacaa cctgagagat
    15601 ggaggagtat tcgtattcaa ttacttggat tgtccaaaag aaattgaatt aggagaaaaa
    15661 agaccaacat tcttatttga caaagataaa aaaggttatg caataataag cgaaaaaata
    15721 ttagaggata gatcaatagt taatatttac agtgaaacca atatagatga taaaactaag
    15781 agatacatta cttcaacatc caaatatcta ttaaataatg aaatgattag taatattatt
    15841 gatcaaacag ctttcaaaca tgaaaaaaca tatactttga atgctgttaa ttatgagaca
    15901 ggtaaaatga aatttgttgt cttaaaaaag taaaggagct attgctatga taaaagtaga
    15961 acatttatct aaacagtttg ttaagaagaa gagacggatt aatgttatta atgattttaa
    16021 ttatgaattc cagtcaggga aactatattt gattaaagga gaatcgggaa agggtaaaac
    16081 cactttactc acattgcttg catttttgca aaaagaagat ggtggtaaaa ttatttttaa
    16141 tgatattata gttagtaacc tgaaacaaga agagaaatgt aatcttcgta gaaaagagat
    16201 aggtatagta tttcaggatt acaatctttt tgataatctc acagtaatgg acaatgtagt
    16261 tattgtagat gtgctgaaaa acaagattaa taaagaagaa atctataata aagcaaaaga
    16321 cataattgga atacttggat tagaagatag aatcaaccat tatccatatg aactgtcagg
    16381 aggagaacaa caaagagtag gtattgcacg tgctatactc aaaaatccat ctattctgat
    16441 atgtgatgaa cctgtatcta atcttgataa agataatgca gtcaacattg tagaattcat
    16501 tgatggttac tgtcataaca aaaataaaat tgtaatagtg gcaagtcatg atgattattt
    16561 tgatgattgt gctgattatg taataaatct gtagggaggg aaataatatg agcaaaaaga
    16621 ttttcatgga tatttatttt gagaagaaaa gattcctaat aatatttttt gtttttcttg
    16681 ttctgctttt aacctatgga ggagtacaat atcaaataat taaacagcag actaaatctg
    16741 ttttaacacc tgatatcaac cttaaaggta aatcaagcca ggatggagtt ttccattatt
    16801 ggttatatca tgatgtggat ggattatcag atgcattgaa agaactatat ggaaaagata
    16861 tgagcgtata taaaaccatt acaagaaatc tttactatat agatgatcgt cttacttttc
    16921 aaagtatata ttatgtaatt accggtgttg aagacaaatt ctttcaacaa gaattaaaga
    16981 acagtgttgc taaaggaagg ctgccaagga gtggtgagaa agaagtagta attggtccat
    17041 attcagctaa ggaatataat ctaggtatag gtgatttggt gaatctaagt gtcacattag
    17101 agaaagatat agctgatgta gaacctaatc aatataaagt agtaggtata ttggacgaca
    17161 atgtagagca attcaaatct tcaatcatgc tttctataga tacatatgaa actttgaatg
    17221 atacaaaagt aatagaaaat gaagttctag tgtattttaa gaataatgat agcattaata
    17281 tctacaaaga tactatctct gaatttacta acatgatagg agaatataat gtgggaagta
    17341 catcttccaa ttttaaatct aataataata agcatagtaa tataataata aatattgtta
    17401 tgatgcttgt cagcaacttt atcatagttt tcttattgat atcgtatctg atgaaaggct
    17461 tatccaaaaa gataggtttg ttaaaagctc taggactatc caatagatat atcaataaaa
    17521 tctttgtagg aggattatct atagtggtag gaggagtatt tgtcatttct attttattag
    17581 tgtccttgat cttgaatgca atgaataata gtgcaactag ttttttggga tatgagatga
    17641 acatatattc tatggatact ggagtcatca tatatatggc agggctttgc ttgtttatta
    17701 taatcatcaa gtatgtactg attaaactta agacatatag aatatatcct atggaagcta
    17761 tggtgaagta attaaatatc tgattgtaaa ttgttatagg gggaaagcct atgaaaagag
    17821 atacaaaact attattggtc ttaactgtga tatgtatatc atttattttt gtattcaatt
    17881 taatgaatag acagcatacg tccaaagcag cgtttgagga agctgtggat tttggaaagt
    17941 actcagacag tatatttata ccttttgatg tcaaaaaaga ttccatattg aaatttgaat
    18001 gcagtgcatc tgtagaacaa gggaatatta caatacagat tattaataag ggaaatgaaa
    18061 tcctatatac aaaaagcgga agcaactacg aggattctgt ggatgtgaag ataccagaag
    18121 gtttatggta ttgtaatatt attattaaca atagtaattc tccagatgat atggctgaaa
    18181 aaggaactta tagtgtttat ggaaaactaa aataatataa attataacaa gagaactctt
    18241 taattaaaat tattgattaa ggagtttttt attatgtata aagataatta ttatatacct
    18301 cattattttt gttgaaaaca tacataatac tatgtccagt aaaatatatt atattaataa
    18361 taagatacat gagataaaat aacaacatta ttttttttag ctgatcttag acaacttgtt
    18421 actagatttt atataggaca ttagctataa gttaactatc aattaataaa aagagattgc
    18481 gggaggtatt attaatgaag cagttaaaaa gattgttttc aattttttta gtattagccc
    18541 ttactgtatc aatgtttgta gggtgcggta aaaaatcaac tggtgactgg aagataggta
    18601 tcattactgg tacagttgct caaaatgaag aagaatatag ggctgcacag aggacaaaag
    18661 aagtattcat ggagagatat ggcgaagata aagtcatcct tcagacttat ccagaaaaat
    18721 tcatggatga acaagaaact gttatagcca atatagctgg tattgcagct gatccaaaag
    18781 taaaggctct tgttatatgt caagcggttc ctggtacatc agcagcaata gacaaggttc
    18841 tcgaaacaag agatgatctg ttgataattg ctgctacatc aggagaagat cctaacatga
    18901 tagctgacag agcggatcta tgtttccaaa tggatgaagt tggaatgggt acagctatag
    18961 ttgagcagat aaaaaaacag ggagccgaga cattggttca ttattcattc ccaagacata
    19021 tgtcatatgc tctacttgca gcaaggagag acctactaaa ggaaaactgt aaaaaagaag
    19081 gtataaaatt tgttgacgcc actgctccag acccaactgg tgatgcaggt atatctggtg
    19141 cacagcaatt catcctagaa gatgtaccta aaaagattaa gcagtatgga gaagatacag
    19201 ctttcttctc aaccaactgt tccatgcagc caccattgat aaaatctata ttacaacaac
    19261 atggaatata tcctcaacct tgttgtcctt ctccatatca tggatttcct tctgctctac
    19321 aaattgaaat cccagaggac aaaaaaggcg atgctaacta tgttgttgaa caaataagaa
    19381 gaatcaatgc tgaaaacaat atgacaggca gaatgtctac ttggcctgtt cctgttaata
    19441 tgatgtttat tgaagctggt gcagagtatg cgtcacaatg gattgaagga aaatgggggg
    19501 ataagataga taacgaaaaa ttaaaagaat gttttgttga ttatacaagt aattatggtg
    19561 atgacattga tatcaatgtt actctactag aagaaaacgg taagaaattc gataattatt
    19621 tcttagttct tatagactat atagacttat aaaaactatt acttatatag gtaggagctg
    19681 actcataata catctatcaa gagtttaccc attaaaagta ttatgagaca gctcttttta
    19741 ttatctaatt aaaaatatag gaggagaaca atggaatgtg attatttact tgaaatgaaa
    19801 aatattagta agaattattc aggtaatcag gttctaaaag atgtagaact aaaagtaaaa
    19861 cctggagaaa tacattgctt agttggagaa aacggtgcag gtaaatctac tttgatgaat
    19921 atactttttg gaatgggcgt aattcataat acaggtggat ttgaaggaga agtatacttt
    19981 gaaggagaaa aagttgatgt gaaatctcca aaagaagcaa tgcagttagg tattggtatg
    20041 gtacaccaag aattcatgtt gattccagaa ttcactataa cagaaaatat aaaattaaat
    20101 agagaaatct tgaaagataa cttagtaagc cgtgctctag gggaaaagct aaaaacagta
    20161 gatttcaaaa gaatgaataa agatgctaga aaagctcttg atacactgga aataaatatt
    20221 gatgaatgga taaaagtagc tggtttacct gttggacata tgcaattcat tgaaattgca
    20281 agagagattg ataaacaaaa tgtaaaactt cttgtctttg atgaaccaac agctgtttta
    20341 gcagaaagtg aagcaaaaaa tctcttaaca gccatgaaga agatagccaa ttctggaatt
    20401 gctattcttt ttattacaca taggcttgat gaggtcatat ccatagcaga taatgttact
    20461 attctacgag acggagtaag agtgtgtaat aaaagagcag aagaaacaga tgttggggaa
    20521 ttggctgaac ttatggttgg aagaaaaata gatatacaaa ataaacaggc tagcaaaaat
    20581 atctcacagg aaattatact ggatattaag aatttatatg tagatatgcc aggagaaaga
    20641 gttaaaggta ttgatttaca gatacgtaaa ggtgaaatat ttggaatagg tggacttgca
    20701 ggtcaaggaa agatagggtt agccaacggt ataatgggtc tatatccatc aaaaggtgaa
    20761 gtgctctata acggagaaga attgaacctt aatgatacaa aaaatacatt aaaaaaagga
    20821 tttgcttttg tatctgaaaa cagaaagaat gttggtttga ttcttgatga atccattgaa
    20881 cttaatatga tctttactgc actcaatata aaagagcagt ttttgattaa tcttggatta
    20941 tttaagctaa agaacttcac taagattaaa aagtattcaa tgaaaaggat aaaagaactg
    21001 gatattagat gtacaagtag tagacaacat gtgggaagat taagcggtgg gaatcagcag
    21061 aaagtatgta ttgccagagc acttactcaa gagccggatg tattgtttgt ttcagaaccc
    21121 acaagaggta tagatatagg tgctaagaaa ttagttttag accttttatt aaaacttaat
    21181 gaagaattgg gtatgaccat catcatgact tcctctgagt tagcagaagt aagaagtata
    21241 gcagatagaa tagccattat aagcgagggg aaattagctg gaatattgaa accttccgat
    21301 actaataaaa aatttggatt acttatgtca ggtattccat taaacaaaat aatggaagag
    21361 gaggcgtaac aatgaagacg gtgattaata aaattggtat ccccagatta attatctcta
    21421 ttctattt
//
