LOCUS       NZ_CP058561            22653 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Vallitalea guaymasensis strain Ra1766G1 chromosome, complete genome.
ACCESSION   NZ_CP058561
VERSION     NZ_CP058561.1
KEYWORDS    RefSeq.
SOURCE      Vallitalea guaymasensis
  ORGANISM  Vallitalea guaymasensis
            Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
            Vallitaleaceae; Vallitalea.
REFERENCE   1  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Vallitalea guaymasensis genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2020) Microbiologie Environnementale et
            Biotechnologie (MEB), Mediterranean Institute of Oceanography (MIO),
            UMR 7294, 163 avenue de Luminy, Marseille 13288, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. JUNE-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141425.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:20:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,859
            CDSs (total)                      :: 4,781
            Genes (coding)                    :: 4,757
            CDSs (with protein)               :: 4,757
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 7 of 24
            Pseudo Genes (incomplete)         :: 16 of 24
            Pseudo Genes (internal stop)      :: 1 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4057972
            Orig. end                         :: 4080625
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058561.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22653
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="9"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..22653
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22653
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12653](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12653
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    complement(161..181)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 26.08"
                     /tool="antismash"
     misc_feature    761..780
                     /note="TFBS match to DosR, Hypoxia stress response
                     regulator, confidence: weak, score: 18.21"
                     /tool="antismash"
     gene            complement(1359..2486)
                     /locus_tag="HYG85_RS17375"
                     /old_locus_tag="HYG85_17290"
     CDS             complement(1359..2486)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025644.5"
                     /locus_tag="HYG85_RS17375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17290"
                     /product="DHHW family protein"
                     /protein_id="WP_212690721.1"
                     /transl_table=11
                     /translation="MKSIHNAILGIIFIIIIFGIMIANIITPDKKFSENENRYLSNSPK
                     FSIEKLVSGKYAKDIEKYIDDQFIMREKWIVAKSNIEQLLPRKDINGVYLGKDNYLIEK
                     HLDKDFNYTQLDENIAIINSFSEEYEHLNIDLMVVPTSGLILENKLPWNAPQFDQQKVI
                     DDIGDKITSSNYIDITGTLSSHSNEYIYYKTDHHWTSLGAYYAYVDYCKSTGTDYKPYE
                     AWDIENAATSFRGTLYSKVLLNGIYDDIGLFKNKQQNPYKVYYNFSKTTSNSVFKYDKI
                     DEKDQYQVFFGGNHGELKIVNEEKNTKNLLVIKDSYANCFVPLIMNQFGKVCMIDLRYF
                     NSDIDKYIEENNITDVLFLYGIMSFSNDTGFRKLQ"
     gene            complement(2499..3905)
                     /locus_tag="HYG85_RS17380"
                     /old_locus_tag="HYG85_17295"
     CDS             complement(2499..3905)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008976379.1"
                     /locus_tag="HYG85_RS17380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17295"
                     /product="MBOAT family protein"
                     /protein_id="WP_212690722.1"
                     /transl_table=11
                     /translation="MIFSTPIFIFLFLPCILAVYYISPSKLKNTSLFLASLVFYAWGEP
                     VYVSIMLFSTVFDYMNGLSIEKFKSQKKYNKAKLVLIISIVGNLAILFFFKYSNFLISN
                     INQLTTLNITPLDLKLPIGISFYTFQTMSYTIDVYRGEVKAQRNIIDFGTFVSLFPQLV
                     AGPIVRYKTIAEQLKNRVSSINKFSEGVQRFIIGMGKKVLLANNIGMLWEQISNSDLTI
                     ASAWLGAICFSLQIYFDFSGYSDMAIGLGKMFGFDFLENFNLPYISKSITEFWRRWHIS
                     LGTWFKEYVYIPLGGSREGKKKLIINMLIVWALTGLWHGANWNFVFWGMYFGILLILEK
                     LVFLKWLKRLPDFVQHFYTLFLVVVSWVIFAIDDTSKLKIYLQTMFGLGNVPLIDKQTI
                     YLFCTNIFLIIICIVASTRLQTIINTKLMNFRHEGLIYTVKNICYITIFIVSICFLIGA
                     SYNPFLYFRF"
     gene            complement(3972..4433)
                     /locus_tag="HYG85_RS17385"
                     /old_locus_tag="HYG85_17300"
     CDS             complement(3972..4433)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025628.5"
                     /locus_tag="HYG85_RS17385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17300"
                     /product="DUF4358 domain-containing protein"
                     /protein_id="WP_113674296.1"
                     /transl_table=11
                     /translation="MKRFICILLTMTIGLFTLVGCGGKDKDITIDISALAGDLTSKIEF
                     QDDLTKIEGNSIESIYQIDYAVSSEVYVSSGATAEEVAVFELKDETEADNAYKAAGERI
                     DAQKQAFESYVPEEMEKLDNAVVKKVGKYVIVCVANDNTAEDIIGTYTD"
     gene            complement(4468..5460)
                     /locus_tag="HYG85_RS17390"
                     /old_locus_tag="HYG85_17305"
     CDS             complement(4468..5460)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024863.5"
                     /locus_tag="HYG85_RS17390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17305"
                     /product="GDSL-type esterase/lipase family protein"
                     /protein_id="WP_212690723.1"
                     /transl_table=11
                     /translation="MNNYSRATRMNYIRKKRRKRIRRMLLLVILISLTLSVKCQEGHYK
                     KSHDLDASATTNPSTDLNDKNPETNQESIEYLFKDEDQKPKEEKPVEPAQPETKLNTNS
                     DSDENDNNSESHEKIDETVTDDYDYTKQVPLGEPVEESYFDDAVFIGDSRTEGFMLYSP
                     PSSKALSYTYKGLMVDTVFTSEVIKKDGKKIPVMEALKNTDFGKVYIMLGINETGWISN
                     DIFIEKYEKIIDSIRESHPDAIIYIQSILPVSHRVSSTHSYIKNSKINQYNSRILEMAR
                     DNGVYYVNVAEAMTNENGCLPKEAAVDGIHLKKSYCQKWLDYLKTHTIK"
     gene            6050..6643
                     /locus_tag="HYG85_RS17395"
                     /old_locus_tag="HYG85_17310"
     CDS             6050..6643
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS17395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_17310"
                     /product="hypothetical protein"
                     /protein_id="WP_212690724.1"
                     /transl_table=11
                     /translation="MKKINAVGTFIMMMALVIILAACSKDNQDTGKDKIDELESKNEKV
                     ELIEEFTEMLKNNQNRTVMFGEFVDTTHYVYAVTDQLDKEIEKIMIVGIDENGDKVDMK
                     YEGRDFEDDGDLSPIPKISKIFINQLKDNENPNVVVFREDKQYIKAQLLEVDTEKKAIN
                     YIGSCMKDKKTEEYTGDETYKYVMDFSEADYCSE"
     gene            7003..8484
                     /locus_tag="HYG85_RS17400"
                     /old_locus_tag="HYG85_17315"
     CDS             7003..8484
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS17400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_17315"
                     /product="hypothetical protein"
                     /protein_id="WP_212690725.1"
                     /transl_table=11
                     /translation="MKKITSVLLSLIMIISLFTINSNASSSDEKITLTSWIINENLVQD
                     AFNKCEIPEKNKESKLYIEKIDILNNTINIVGEINSSRFSLIGKLYKSRKSDQGIYVAD
                     VKDEFNNFKIHLLELNFNSNQKAVFNKQIIEEPIFTLYMSDNNGNIILTEDKLSKVIDN
                     NRLKIETMASSRIDSFWFIDLLKPIKSIVIKSSEVQQMIELRANEKNNNTFINNKSISN
                     SIVSSELLNKINYNSVLLDDIISNVEAKRKVSLNTLTTTRSTQGYLWAGDIHIDYYKPG
                     WDTYTYKMCPYVDGLIADIPKAGSGTWTSSLRMSESVYINDVHYPELENLFKIKNAEVK
                     IGAGNNTQIASRIIGGTYHKGGGIDTSKTIKAWLSLATNNIPVVSDVNKVYKFINSIKP
                     VYSPVTITKGDLQNLGVDKRAVYVKYDSDTYLADGVDHFDINLSCLVMDNNLVKNVNTQ
                     SVIQWKFDVYFTTIHKESYSYDNTTEEKDYESNVW"
     gene            8624..9238
                     /locus_tag="HYG85_RS17405"
                     /old_locus_tag="HYG85_17320"
     CDS             8624..9238
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS17405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_17320"
                     /product="hypothetical protein"
                     /protein_id="WP_212690726.1"
                     /transl_table=11
                     /translation="MKKSQKFLLALSIIIIIFIAFILGMKYEHNNSNKDINKFYNDFFI
                     DKELEMIAANEYLIYELKNIENNEAIDMKDYIAIYKQLEIINYISLEYTIKLQEYLNMI
                     NYWSNHELKSNKEAMTIYFNFLQNLSDNLDGFSKSNGTIDLTIEKINSNKQVIQHLVDM
                     NNQIHSILDLYDVEKELKANVLSERLALLDYIFDSVENLSD"
     gene            complement(9321..9491)
                     /locus_tag="HYG85_RS17410"
                     /old_locus_tag="HYG85_17325"
     CDS             complement(9321..9491)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS17410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_17325"
                     /product="hypothetical protein"
                     /protein_id="WP_212690727.1"
                     /transl_table=11
                     /translation="MQKKMNKIKLYIDTNQANIDPQCLQEIIDLIIINPTQAEIEEILT
                     DYDVIYERLKQ"
     misc_feature    9876..9893
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 20.02"
                     /tool="antismash"
     gene            10001..10285
                     /locus_tag="HYG85_RS17415"
                     /old_locus_tag="HYG85_17330"
     CDS             10001..10285
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017239.5"
                     /locus_tag="HYG85_RS17415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17330"
                     /product="PqqD family protein"
                     /protein_id="WP_212690728.1"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.8e-07,
                     bitscore: 29.2, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.7e-09, bitscore: 35.3,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLITRKMGVIDRFEPEEEEYLLYDSNKNRIKILNKTGAYIWSLIP
                     DNEFINVDDITNELNKKFDTQVGNEKIKEDAKLFVSDLIKGEVVVAREE"
     aSDomain        10052..10270
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYG85_RS17415_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="1.00E-09"
                     /identifier="RREFam002.1"
                     /label="HYG85_RS17415"
                     /locus_tag="HYG85_RS17415"
                     /protein_end="90"
                     /protein_start="17"
                     /score="29.2"
                     /tool="antismash"
                     /translation="EEYLLYDSNKNRIKILNKTGAYIWSLIPDNEFINVDDITNELNKK
                     FDTQVGNEKIKEDAKLFVSDLIKGEVVV"
     gene            10269..11345
                     /locus_tag="HYG85_RS17420"
                     /old_locus_tag="HYG85_17335"
     CDS             10269..11345
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="HYG85_RS17420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17335"
                     /product="radical SAM/SPASM domain-containing protein"
                     /protein_id="WP_212690729.1"
                     /sec_met_domain="PTHR43273 (E-value: 3.1e-48, bitscore:
                     162.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 3.1e-13, bitscore: 48.6,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.7e-08, bitscore: 32.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 3.9e-09, bitscore: 34.4,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 6.3e-11, bitscore:
                     40.6, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 2.7e-07, bitscore: 29.1,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLEKNSFSLPTNLFLSITNRCNLKCPHCYLDSSAQYNDLDTKAWI
                     KIARDTAKAKIFSIVITGGEPLVRKDFIDIIEAFDIWQTLKLNTNATLINDKIAKFIAG
                     RFLTVMVSIDGPQLIHDSIRGKGSYNKTVQGLKMLMNYLDKSKIYINCTISKKNAKYME
                     QTINDMLSLGINNLMFGEAINVGRLDSQDNDQFSLSIIDKLYIANKIKFLQNKYGKEID
                     ISTDYFEDYINLFKSITDCSYSGLSDIPLINCGAGFKSAAILYDGYMVPCNMLSQDFCD
                     DEDNVLVNSIEDIWKHSRRFIQWRDQKNIKISDICTECDLKSRCYGGCRAESYYKYKNL
                     KNRCDSNCIINEVDKQII"
     gene            11619..12653
                     /locus_tag="HYG85_RS17425"
                     /old_locus_tag="HYG85_17340"
     CDS             11619..12653
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SPASM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015983.5"
                     /locus_tag="HYG85_RS17425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17340"
                     /product="radical SAM/SPASM domain-containing protein"
                     /protein_id="WP_212690730.1"
                     /sec_met_domain="QueE (E-value: 5.8e-13, bitscore: 47.0,
                     seeds: 32, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 2.8e-44, bitscore:
                     149.8, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2e-09, bitscore: 35.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 2e-20, bitscore: 71.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.8e-11, bitscore:
                     42.4, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.6e-05, bitscore: 23.4,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIQSLFIYLTFKCNLKCEHCWAYSGPDVKEDELSLETIKRTIDE
                     AYNMGMRSLKLTGGEPLVLKNYVTNIIDLVNNYGDVRLRMETNGILLDDKMIKLLNDNN
                     IYLSISLHSSKAPKHDQIVGKEGAFDKVISVIPKIKNKEILVTISKKNMDELEDILKLL
                     SSIGANSVKFNILQTVGRGENLDRLTRPDMINIHKRIENYTKENESMEIDTSAPMCTGL
                     YSLNNFYYPKSSKGCNFGSVCCLTPGGNISLCGWSKSKKDSELLLGNIENEKLKDIWKR
                     KELVVKKTEPLEGVCNNCLFLKLCKGGCRAIAYEVYGKLNAPDPICQVMYEEGEFPKSK
                     LIAN"
     gene            12703..14559
                     /locus_tag="HYG85_RS17430"
                     /old_locus_tag="HYG85_17345"
     CDS             12703..14559
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HYG85_RS17430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17345"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212690731.1"
                     /transl_table=11
                     /translation="MNKLKEKKKKRKLEYNTFNTIIYLFKHIWLWDKPLIFYFLIYSIT
                     AGIIPFIGIFLPKMIIDELVGLKRINILVIIIASFCIGGLLLNLIKVYSQEVYWPRVIQ
                     IRMEFIHKIDKKAMTMDYQQLERVNTKDLIQRAWMALSGNDIGVEGILNQIFVLFGNIV
                     AFGGYIAIISTLSPLIVFFLILTVGITYKASLGEKKYSHQVDRQMAINERKLKYLDKKM
                     VNHSLAKDIRLYDMAKWLTNKYITWCNEIYLKLKKIAIKRFKIDTLQGFLSFVRNGIVY
                     VYLINRVLYNGMSIGNFTMYFASIQGFSGWMESVVSSILSIRQQNLYINDYRNFVDAKE
                     PNKNDNRDSMKKDISDRVYKIKLENIFFKYPNSDNYTINNVCIHVKDGEKVAIVGANGA
                     GKTTLIKILTGLYKPTKGKVVVNGIDSTNIDKNEYFKLFSVVFQDIKLYAFSLGENISL
                     RKIDETDRQKAINCLKSAGLSDKLKNLENGIDTSLLKILDEEGIVLSGGEIQKVALARA
                     LYKDAPILVLDEPTAALDPIAEHELYEQFDRLTKGKTAIYISHRLASTRFCDKIILLDK
                     GSIKEYGTHEQLMKINGTYAKMFHKQARYYNSDIKDHKEVLA"
     gene            14559..16385
                     /locus_tag="HYG85_RS17435"
                     /old_locus_tag="HYG85_17350"
     CDS             14559..16385
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HYG85_RS17435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17350"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212690732.1"
                     /transl_table=11
                     /translation="MKKLYNNLTMEFNVIFFILKLTNEYSKAFLPLTILLALISSFLTI
                     YNLLMSRKIIDELILGKQFNKLLEIIILLIGVNLLMHIIRSIIFRWLQAKNQFIKKRFN
                     LEINKKTMSMDYEYVENPKILDAKERALSGINQSGGINTFTNNIRNIITCICTIMGLLY
                     ILNDLSIVIILILIIMIIFNYIAESKRQKAEYHSWQKNAKNNKMFSYLDGEVIKDYKAS
                     KYIRLYDSSEMILSRYRQFDKKSQRLFRLISSSNKKHYLIINILDYSQKFIIYFTLALK
                     VISEPSKFTIGSFTMYTSALYNLISSITKMFKSAVKIKYTCKYLKLYKEFIELPPILCK
                     NNEHIPANTNYSFEFSNVSFAYPGMNKLVLKNINLKIPSKQKLAIVGLNGAGKTTFIKL
                     VMRLYDPKNGEILLNDNNIKKYNYREYQNLFGVVFQDSNILSFTVKENICLENSSSTQN
                     DIVIECLKNAGVGDKIDVLENGADTYVDRIFDDKGIEFSGGEMQKIAIARAIYKNASIM
                     IFDEPTASLDPLAEYEIFNTLHELTYGKTAVFISHRLSSTRICDCIAVFHNGEIIQYGS
                     HDELMKDREGKYYKMFMAQAQYYVSNDEVSCI"
     misc_feature    complement(16430..16444)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            16449..17054
                     /locus_tag="HYG85_RS17440"
                     /old_locus_tag="HYG85_17355"
     CDS             16449..17054
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024808.5"
                     /locus_tag="HYG85_RS17440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17355"
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_212690733.1"
                     /transl_table=11
                     /translation="MLSTYEALTEPKWAGKVLVRSSSNIYNQSLLASFIALNGEEADAE
                     WAKGLVANMARTPEGNDRDQMKAVVAGEGDVAIVNTYYVGKLLNSSDEYEVEVGKKIGV
                     YFPNQETTGTHINISGGALTKHGKNSESAIKLLEFLTGEEAQDDYANANYEYPVNPKVE
                     PSDLLKSFGDFDIQEIDLSLLGEYNDEAVKIFNKVGWQ"
     gene            17059..18684
                     /locus_tag="HYG85_RS17445"
                     /old_locus_tag="HYG85_17360"
     CDS             17059..18684
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1214:
                     binding-protein-dependent transport systems"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.5"
                     /locus_tag="HYG85_RS17445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17360"
                     /product="iron ABC transporter permease"
                     /protein_id="WP_212690734.1"
                     /transl_table=11
                     /translation="MRNVMKGRRISPLHVIASIIIMLILLPSLMIVIQLFQPVTESWIH
                     IKTYLLKDYLINSITLIFLVGGVTCLLGIFFAWSLSRYRWKYTKTLEILLFLPMAIPPY
                     IGGYVYGGIFTSFGTLHRIMLTLGLKPIKIDILSMGGAVCVFSLFLMPYVMLVTKGFFN
                     RLPKNIEESSRLLGKSRFQTFYKIILPMSRGAIIGGVILVALEVLNDYGLVKYFGIPTF
                     STAIYTTWFGLSDVDGAIRLASSLMIIVIIILLVEQFFRGRGRLSQAKAVPDLGTKKAA
                     PIGYKILFYIVGTIYLLLSLIIPVAQLIHWSTLAKDTVVLRNLDKILKNTLITAIIVTI
                     VIIICSSIIGNLNRLHSGIITKIYARIVIVGYSIPASIIAIAVLVFFIAADRNLGGIYG
                     FFGLKNLFLTSSVFMLIFALTIRFMAIGYNSVESGFSKMGLKYYEASKLLGKGEWHTFT
                     KVDLPILKPAIISAMILTFVDVLKELPLTLILRPFNFDTLATKVYTYANDEMIHEGSIY
                     ALMIIGVSTLALVFLLGFRKEKAE"
     gene            18681..19352
                     /locus_tag="HYG85_RS17450"
                     /old_locus_tag="HYG85_17365"
     CDS             18681..19352
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.5"
                     /locus_tag="HYG85_RS17450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17365"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212690735.1"
                     /transl_table=11
                     /translation="MIECKDISFRYSNAIEPTLNKVSFSLHNGGVLAVVGPSGGGKSTL
                     LRVIAGLETPYEGTLSINNKVVFNVNNNVKPENRGIGMLFQDYALFPHMTVKKNIEYGI
                     DHLPKKERKQRLDEVLELVALGGYEKRYPHELSGGQQQRIALARALAPKPKLLLLDEPF
                     SNLDTHLLKKVRDDLFNIIRKTNITTIMVTHNPEDAKAEADKIISIVDGRIDREVMNMK
                     D"
     gene            19673..20410
                     /locus_tag="HYG85_RS17455"
                     /old_locus_tag="HYG85_17370"
     CDS             19673..20410
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS17455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_17370"
                     /product="hypothetical protein"
                     /protein_id="WP_212690736.1"
                     /transl_table=11
                     /translation="MKKISIIIVILIFIIVALNQIIGDKDLIIDKIKDTKSNKDIVLLF
                     DEEKINLQFDNKEVGVKSIPKDLIDDYEYSLKIIGNYLLVGMINKKTVKYSSLTFLYLY
                     DYIQNPITKIWSTDDELKKELFLKNYNTTNNTIIVDSDSSEVIIEYDEKIENKLMEFIK
                     SIKEKDKKIQLEISNTVAYCIYDYDKDGQEELITKSIVTMGFSPLVDTYYSVYKIEDNG
                     IQKVKSCFYSKDNTLEKYFKNFN"
     gene            complement(20448..21002)
                     /locus_tag="HYG85_RS17460"
                     /old_locus_tag="HYG85_17375"
     CDS             complement(20448..21002)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR02937.1"
                     /locus_tag="HYG85_RS17460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_17375"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_212690737.1"
                     /transl_table=11
                     /translation="METKWTELILTFKQSQDKTQNEKIVINIINSFNPLINKYARKLSY
                     DEAQSDLIIYLIKSIYKIPDLSGDAKIVKYFSNSLYYGYIKLLKKDIKIKNNEIIVDFC
                     NEKYNNLIKDYGEITDIKIDINHSIDLLPKKERKIIQYKFFEQKTYTEISRKINLTRPT
                     IKKYEEKGLAFLKNELKSYIE"
     gene            21172..21900
                     /locus_tag="HYG85_RS17465"
                     /old_locus_tag="HYG85_17380"
     CDS             21172..21900
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS17465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_17380"
                     /product="hypothetical protein"
                     /protein_id="WP_212690738.1"
                     /transl_table=11
                     /translation="MKDSKIKTLLLSTLLLTIIFTSSWSTYAEEINYEKVCSFQEVEHE
                     WIGDYTGEYNRPRYLRYEAYDKMGKKISSSQVSSLSNVEKVARTILGEICNVPPRIDNA
                     YAVAQAIKNRMDYDNKTAVQVISSGFDAYGGGAFKDPLNYYYLEDEYRLWAECAWLAAC
                     LVEGDSIPTSGYDDIGNSRFFGDISVSSYLKRFKLSNGTTCNETNIESATTFVCWGRKN
                     PILNTVKKFGNHVYFEVNDR"
ORIGIN
        1 aacatttatt acaattatga aagaagcaga tcaaattgga gttgtagctt tttccacaag
       61 gagtagaata ttatacccat taacaactat acaatcagac cataaaacaa tatatgatgc
      121 cataaatgaa ataaaaaaga tacaaccaat taatatgact aacataaaag aagctatatc
      181 tcaagggcat gacatactta acaatgcagg caaccctaac agagctatga tacttctatc
      241 agatggtatc tggaatgaag gaggagatcc acttatagga ttacccacag atatccctat
      301 ctatacaatt gctttaggag ataggggaca atgtaatttt ttacaggaag tagcaaggag
      361 aacttatgga cagtaccatt tcagccctga tgcatttgaa cttgctgaga tatataatca
      421 gatagcagat gatgcaagtg tagctacaat agcaataaat caaaaacaac taatagattc
      481 atacagattt acaacactgc ccttatatgt tccaggaggt tctgaccatg taagccttgc
      541 agtaaactgg cttgatgaat cagttaccta tacaacaggt acacctggag aaaatcaagt
      601 caatatatta ttaagagacc ctgatggaca aaaaatagta atgcctccaa cttttatggg
      661 aaatggcttt gtcacattcc atcttcatga tccaaaacca ggtcaatgga ctacagggtg
      721 ctggtgtgga aatatgcgtc aaaatatttt tagagctact gtgggagctt ttgaacctaa
      781 tagtactatc aagcttaact gtaaattggc ggaaacaaaa atgaattgtg gagactgcct
      841 agatataaaa actgcattgg aaagcagtaa agatgagatt ggtaatgtaa taattaaaac
      901 aactttggag tcaccagtta attcaaaaga ttatgttctt gaaaaatatg aagatgaaat
      961 attgaatact gaaccagatg aagaactcat gaaaaagggt attaatgaga tagatgcaaa
     1021 acttaacacg ctacacaaga aattattacc taatgttaat atatttgcac gtagacaaag
     1081 tccagtacat gctaaatact cacaagatgg tgtggaacat gaaccaatta aattagatgt
     1141 acctggtaac catactatta gagttgatgt agagggaact atattaagga gtaatacaaa
     1201 atttacaaga acaagaagat tgagtgttaa tgtgaagtaa aaacatgtaa tataaagggg
     1261 actgtcagat aatacatttt tgagtggtgt aaatgtgata aaatgtatta tggacagccc
     1321 cccattttat atatttaatt aagtaacagc atatattatt actgtagttt tctgaatcca
     1381 gtatcattag aaaaactcat tatgccatat agaaataaaa cgtctgttat attattttct
     1441 tctatgtact tatctatatc actattaaag tatcttaaat caatcatgca aactttacca
     1501 aattgattca taattaatgg aacgaagcaa ttagcatagg agtcttttat tacaagtaaa
     1561 ttcttggtat tcttttcttc gttgacaatc tttaattctc catgatttcc gccgaaaaaa
     1621 acttgatatt ggtctttttc atctattttg tcatacttga aaacactatt actggtagtt
     1681 ttggagaaat tataataaac tttataggga ttttgctgtt tattcttgaa taaaccaata
     1741 tcatcataga taccatttaa aaggactttt gaataaagag ttcctctaaa tgatgtagca
     1801 gcattctcta tatcccaagc ttcataaggt ttatagtctg tcccagtgct tttacaataa
     1861 tcaacatatg catagtaagc tccaaggctt gtccaatgat ggtctgtttt atagtatata
     1921 tattcattgc tgtgactact tagggtcccc gtaatatcaa tataattact tgaagtaatc
     1981 ttatccccta tatcatcaat tactttctgt tggtcgaatt gaggtgcatt ccagggtagt
     2041 ttattttcca atatcaatcc agaagttggt acaaccatta agtctatatt tagatgctca
     2101 tattcctctg aaaaagaatt gatgattgca atattttcat ctaattgtgt atagttgaaa
     2161 tctttgtcca agtgtttctc tataaggtag ttgtcttttc ctaaataaac accattgata
     2221 tcttttctag gaagtaattg ttctatgttt gattttgcaa caatccattt ttctctcata
     2281 atgaactggt catctatgta tttttcaata tccttggcat atttccctga gactaatttc
     2341 tctatggaaa actttggact gttacttaaa tacctatttt cgttctccga gaattttttg
     2401 tcaggggtaa ttatattagc aatcattatc ccaaagatta ttattataaa aataattcct
     2461 agtatagcat tatgtattga tttcacttaa atccctccct aaaatctaaa atataagaat
     2521 ggattatatg atgcacctat taaaaagcag atagatacta tgaatatagt tatatagcat
     2581 atatttttaa cggtatatat taatccttca tgtctaaaat tcattaactt ggtattaatg
     2641 atagtttgca atctagttga tgctacaata catatgataa tcaaaaatat gttggtacaa
     2701 aacaagtaga tggtctgttt atctattagg ggtacattac caagtccaaa catggtctgc
     2761 aaatatattt ttaactttga agtatcatca atggcaaaga taacccagct aacaactact
     2821 aaaaatagag tgtagaaatg ctgtacaaaa tcaggtaacc tcttaagcca tttgaggaaa
     2881 accagctttt ctagaattag caaaatacca aagtacattc cccaaaaaac aaaattccag
     2941 ttagctccat gccatagacc agttaatgcc cagacaatca gcatattgat aattagtttt
     3001 ttctttcctt ctctacttcc gcctagggga atgtagacat actctttgaa ccaagttcca
     3061 agagagatat gccatcttct ccaaaattca gttatgcttt tagagatata aggcagattg
     3121 aagttctcta agaaatcaaa tccgaacatt ttaccaagtc caatagccat atccgaataa
     3181 ccagagaaat caaaatatat ttgcagactg aaacagattg cccccaacca tgcagaagca
     3241 atagttaaat cagaatttga tatctgttcc catagcatac cgatattatt ggctaataac
     3301 acttttttac ccatacctat tataaaacgc tgtacacctt cagagaactt attaatactg
     3361 ctgactctat tttttaattg ttcagctatt gttttgtatc ttactatcgg tccagctact
     3421 agttgtggga acaatgaaac aaaggttcca aagtcaataa tattcctctg agctttgact
     3481 tcaccacggt aaacgtctat tgtataggac attgtttgaa atgtataaaa ggatatacca
     3541 ataggaagct taagatctaa tggtgttatg tttagtgttg tcaattgatt gatgttgctt
     3601 attaaaaaat tactgtattt aaagaaaaac agtatggcta gatttcccac aatggagata
     3661 atcaagacaa gtttagcctt attatatttc ttttgggatt tgaatttttc aatagataga
     3721 ccattcatat aatcaaaaac agttgaaaaa agcattatac taacatatac tggttctccc
     3781 caagcataaa aaaccaagct cgcaagaaac aagcttgtat tttttaactt acttggactg
     3841 atataatata cagctaaaat acatggcaaa aacaaaaata tgaaaattgg tgtgctaaaa
     3901 atcatgagaa aatacctccg ttattttcgg gtcgcagggt aggaagttgc atgtattatg
     3961 ttaaagaata attagtcagt atatgttcct attatatctt ctgctgtgtt atcattagca
     4021 acacaaacga tgacatattt accaactttt ttaactacag cattatcaag tttttccatt
     4081 tcttctggca cataactttc aaaagcttgt ttttgagcat caattctttc cccggctgct
     4141 ttgtaagcat tatctgcttc cgtttcatct tttaattcaa acactgcaac ttcttcagct
     4201 gttgctccac tgcttacata tacttcagag gatactgcat aatctatctg atatattgac
     4261 tcaatgctgt tgccttcaat cttagttaag tcatcttgaa attctatctt actggttaaa
     4321 tctcctgcta aagcactaat atcgattgtt atatctttat ctttgcctcc acatccaacg
     4381 agtgtgaata atccaatagt catagttagt aaaatgcaaa taaatctttt cataatcttt
     4441 ttctccttag ttatcttaat taatatttta tttaatagta tgtgttttta gatagtcaag
     4501 ccatttttga caatatgact ttttcaaatg tattccatca actgctgctt cttttggtaa
     4561 acaaccattt tcatttgtca ttgcttctgc aacatttaca taatatactc cattatctct
     4621 tgccatctca agaatacgag agttatattg attaatcttc gaatttttta tgtaactatg
     4681 agtagaggat actctatggc tcacaggtaa aatcgattgt atgtatatga ttgcatcagg
     4741 atgagattct ctgattgaat ctataatctt ttcgtatttc tctatgaaga tatcattaga
     4801 gatccatcca gtttcattaa tacccaacat aatgtatact ttaccaaaat cagtattttt
     4861 tagtgcttcc atgacaggta tttttttacc atctttttta attacttcac ttgtaaaaac
     4921 agtatctacc attagtcctt tatatgtata tgataaagcc ttagaagaag gaggggaata
     4981 tagcataaat ccttctgtac gagaatcacc tataaacaca gcatcatcaa aatagctttc
     5041 ttcaacgggt tcacctaagg gaacttgttt ggtataatca taatcatctg taacagtttc
     5101 atcaattttc tcatgggatt cagaattatt atcattctca tctgaatcag aattggtatt
     5161 taattttgtt tctggttgcg ctggttcaac aggtttttct tcttttggtt tttgatcttc
     5221 gtccttaaac aaatattcaa tggattcttg gtttgtctct gggtttttat cattgaggtc
     5281 agtgctcggg ttggttgttg ctgaggcgtc taaatcatgt gactttttgt aatgaccttc
     5341 ttgacatttg acgcttagtg tcaagctaat caatattaca agaagcaaca ttcttcgaat
     5401 tctttttctt cttttttttc taatgtagtt catgcgtgta gctcttgaat aattgttcat
     5461 gttttcccct ttctttggca ttattatttt atacttatcc ctcgctggca tagtattttt
     5521 tactataata cttttatact atgttagctt tcatatataa gactattcaa caaagcaaaa
     5581 agttttaata acttatattt ttttacaata aacgatctag taattgttgg aaatatcatt
     5641 taagaatgta gatgcataaa attaagattg agtcatattt gagtttatag aacttttttc
     5701 ttgcttttat tacataaatc attaaaatct tatattgctt cgtaaaaatc aaaaaaacat
     5761 attaagaatg tagtgattgt cattatgaga cgatttctta ttatgataca ctctagtatt
     5821 atatagcata aataaggtta atatgttaaa ttatagttat aattgtatta aataataatt
     5881 actaaaagtg taacaatatc ttaatgattt tgtcctattg actagggacc ttaaaaatca
     5941 agatttttag tggaatttgg ggtgaaaaga aaggttttga catattatgg gatagaggat
     6001 aaaataatag ggctgtagag tcaaagtatg tagaaaggaa tgatattaga tgaaaaaaat
     6061 aaatgcagta ggaacattca taatgatgat ggcacttgtt attatattag cagcttgtag
     6121 taaagataat caagatactg gtaaagataa gattgatgaa cttgaatcaa aaaacgaaaa
     6181 agtggaattg attgaagagt tcactgagat gttgaaaaat aatcaaaaca gaactgttat
     6241 gttcggtgaa tttgttgata ctactcatta tgtttatgct gttacagatc aattggataa
     6301 agaaatagaa aaaataatga ttgtaggtat tgatgaaaat ggtgacaaag ttgatatgaa
     6361 atatgaggga agagattttg aagatgatgg tgatttatca cctattccta aaatcagtaa
     6421 gatttttatt aatcaactga aagataatga aaatcctaat gttgttgtat ttagagagga
     6481 taaacagtat atcaaagctc agttgttaga agttgatact gagaaaaaag cgataaatta
     6541 tattggtagt tgtatgaaag ataaaaaaac tgaagaatac acaggagatg aaacttataa
     6601 atatgtaatg gatttttcag aggctgatta ttgtagtgaa taaagattat tataagagtg
     6661 ttgtgctagc tagaaatata aaattagcta gtatgacact ctttttttat tataataatt
     6721 tttaataatt aatttatgag atttagatta taatggaata aaaatatttt gaaaaataac
     6781 taatatttgt tatatggctt atataataaa ttaaaattct atatgagttt ataaaaaaaa
     6841 ttatactaac aataaaaaaa agataatata atttattggt attatgttat aatatatatt
     6901 gctaattaag tactaataat tatacctatt ttattattaa aggaggtgtg gatttacaaa
     6961 ttttgttaaa ctaatttaaa taagaaagtt gaggtaatta atatgaaaaa aataacatct
     7021 gtattattaa gtttaataat gataatatct ttatttacta ttaattctaa tgcaagttct
     7081 agtgatgaaa aaataacgtt aacttcatgg attattaatg agaatttagt tcaagatgca
     7141 tttaataagt gtgaaatacc agagaaaaat aaagaatcaa agttatatat tgaaaaaatt
     7201 gatatactta ataataccat taatattgtt ggagagatta atagttctag attttcatta
     7261 ataggtaagc tatataaaag tcgaaaatca gatcaaggaa tatatgtagc agatgtgaaa
     7321 gatgaattta ataattttaa aattcatctg ttagagctga attttaattc aaatcaaaaa
     7381 gctgtattta ataaacaaat tatagaagaa ccgatattta cactttatat gagtgataat
     7441 aatggtaata taattttaac agaagacaaa ctatctaagg ttattgataa taatagattg
     7501 aagatagaaa ctatggcttc atcaagaatt gactcttttt ggtttataga tttattgaaa
     7561 ccaataaaaa gtattgtaat taaaagtagt gaagtacaac aaatgattga gctaagagca
     7621 aatgaaaaaa acaataatac atttataaat aataaaagta tttcaaatag tatagtaagt
     7681 tctgaattac ttaacaaaat aaattataat agtgtattgt tagatgatat aataagtaat
     7741 gtagaagcta aaagaaaagt aagcttaaat actttaacta caacacgtag tacacaaggg
     7801 tatttatggg ctggtgatat tcatatagat tattataaac caggttggga tacctatacc
     7861 tataaaatgt gtccttatgt agatggatta attgcagata taccaaaggc tggttctggt
     7921 acatggactt catctttaag aatgtctgaa agtgtatata ttaatgatgt tcattatcca
     7981 gaattagaga atttatttaa gattaaaaat gcagaggtta aaattggagc tggaaataat
     8041 acacagattg cctctagaat aattggagga acataccaca aaggaggtgg aatagacaca
     8101 tcaaagacta ttaaagcatg gttatcgtta gctacaaata atatcccagt tgtttcagat
     8161 gtaaataaag tgtacaagtt tataaattca attaaaccag tatattctcc tgttacaatt
     8221 acaaaaggag atttacagaa tcttggtgta gacaagagag cagtttatgt taaatatgat
     8281 tcggatacat acttagctga tggtgttgat cattttgata ttaatctaag ttgtttggtg
     8341 atggataata atcttgttaa gaacgttaat actcaatcgg ttatacaatg gaagtttgat
     8401 gtttatttta ctacaataca taaagaaagt tattcatatg ataatactac agaagagaaa
     8461 gattatgaat caaatgtatg gtaaaatata acgaaatagt atttataatt ttagggttag
     8521 atatataatt ctgtatacga tgtgtgagag gatagttaat taaatatata gtatatgtta
     8581 ttataattat aaatatatat aatattagag gagtgatttc ttcatgaaaa aatcacagaa
     8641 atttttatta gctctatcaa taataataat aatttttatt gcatttattc ttggaatgaa
     8701 atacgaacat aacaattcca ataaagatat taataaattt tataatgact ttttcataga
     8761 caaagaatta gaaatgattg ctgctaatga gtatttaata tatgaactta agaatataga
     8821 gaataatgaa gcaattgaca tgaaagatta tattgccatt tataaacaat tagaaataat
     8881 aaattatatc tcgttggaat atactatcaa actccaagaa tatttaaata tgattaatta
     8941 ctggagtaat cacgaattga aaagtaataa agaggcaatg acaatctatt ttaattttct
     9001 tcaaaatcta tctgataatt tggatggttt tagtaaatct aatggaacta tagatttaac
     9061 tattgaaaag ataaatagta ataaacaagt aattcagcat ttagtagata tgaataatca
     9121 aattcattca attctagatt tatatgatgt tgagaaagaa ttaaaggcta atgttttatc
     9181 tgaaagatta gcattgctag actatatatt tgatagtgtt gaaaatttaa gcgattaaac
     9241 ataaagaatt aaggagcagg gatatttcca ctgctccttc aattaagttg atgctacgta
     9301 taaatttgtt atcattcttg tcattgtttt aatctttcat aaatcacatc ataatccgtt
     9361 aagatttctt caatttctgc ttgagttgga tttataataa tcaggtctat aatttcttgt
     9421 aaacattgtg gatcaatatt tgcttgatta gtgtctatgt aaagtttgat tttattcatt
     9481 ttcttttgca ttatgctctc tcctcaatag ttgctatatt aactatcggt tttttgctat
     9541 tagggaatta taggataatg ggcttaataa caatagctta tagagatgaa gacgtagaac
     9601 tgttttacta tatgattaga tactttcact tatctgtgat gtatcaatgg aacactaact
     9661 tataggtaaa gtttgatttt cttaacttgt caattatatg taaaataaca attaatttat
     9721 ggaaaaatag taatattata tagctattgc aatttcttga gtttatagcg tgaaattaat
     9781 aagaatatta agattattaa ataattagag taaaaaatgt agaaaataat aattaaattt
     9841 gaatataaaa aataataaaa atatatattg caaatatgta ataaacatgt taatatgatt
     9901 ttagtaacaa tttgattcat aatattatga ttgaatataa gtctatagtt caaaaaatgg
     9961 gacaagccat ttttataatt atttttagga ggcggttgat gtgcttataa caagaaagat
    10021 gggggtaatt gataggtttg aaccagagga agaagaatat ctattatacg attctaataa
    10081 gaacagaata aaaatcctaa acaaaactgg tgcatacata tggtcattaa tacctgataa
    10141 tgaatttatc aatgtagatg acatcaccaa tgaattaaat aagaagtttg atacacaagt
    10201 cgggaatgaa aagattaaag aagatgcaaa attatttgtt tctgatttaa taaaaggaga
    10261 ggttgttgtt gctagagaag aatagtttca gcttaccaac taatttattt ctatctataa
    10321 ctaatcgttg taatcttaag tgtcctcatt gttatttaga ttcttctgcg caatataatg
    10381 atttagatac aaaagcgtgg attaaaattg ctagagatac tgcaaaagct aagatatttt
    10441 ctattgttat tactggagga gaacctttag taagaaaaga ttttatagat attatagaag
    10501 cttttgatat atggcagaca ttaaaactta atactaatgc tactcttatt aatgataaga
    10561 tagctaagtt tattgcgggc agattcttaa cagtgatggt aagtattgat ggtccacaat
    10621 taattcatga cagtatcagg ggaaaaggat catacaataa aacagttcaa ggtttaaaaa
    10681 tgctaatgaa ttatttggac aagtctaaga tatatatcaa ttgtactata agtaaaaaga
    10741 atgctaaata tatggagcag acaataaatg atatgcttag cttaggtatc aacaatttga
    10801 tgtttggaga agccataaat gttggacgtt tagatagtca agataatgat caatttagtt
    10861 tatccattat tgataaatta tatatagcta ataaaattaa gtttttacaa aataaatatg
    10921 gtaaagaaat tgatataagt acggactatt ttgaggatta tatcaattta tttaaaagta
    10981 taacagattg tagttattca gggttatctg atatacctct tattaattgt ggtgctggtt
    11041 tcaaaagtgc agctattcta tacgatggtt atatggttcc ttgtaatatg ctttcacagg
    11101 atttttgtga tgatgaagat aatgttttag ttaatagtat tgaagatatt tggaaacatt
    11161 ctaggagatt tatacaatgg agagatcaaa agaatattaa aatcagtgat atctgtacag
    11221 aatgtgactt gaaatcaagg tgctatgggg gatgtcgagc agaatcttat tacaaatata
    11281 aaaatttgaa aaatagatgt gatagtaatt gtataattaa cgaagtagat aagcagatta
    11341 tttgaagtag ataaaaactg ctttttaatc acaaaaagca gatttttata caatgttaaa
    11401 tttaacaaat acataaggaa agggggataa gtatgggata cgaacaacca ttaatccaag
    11461 atcttgagga aaaggaacct ccagtagctg gacattcatg ctcagatgga tgccgtaatg
    11521 gtaactaatt attgagaatt tacgtaatat gctataaaat gcaggataga attttttaat
    11581 tctattttgc atttgcattt taggaaggag aaaaacatat gggaatacaa tctttattta
    11641 tatacttaac ttttaaatgt aatttaaaat gtgaacattg ttgggcatat tctggtccag
    11701 atgtaaaaga agatgagctt tcattggaaa caattaaaag aacaattgat gaagcttaca
    11761 atatgggaat gcgatctcta aaattaactg gaggagagcc attagtatta aaaaattatg
    11821 taaccaatat tattgattta gttaataatt atggtgatgt tcggttgaga atggagacaa
    11881 atggtatttt gttagatgat aaaatgataa aactattgaa tgataataac atatatttat
    11941 caataagtct acattcttca aaggctccta aacatgatca aatagttggc aaagagggag
    12001 cttttgataa agttataagt gttattccaa aaataaaaaa taaagaaatt ttagtaacta
    12061 tttcaaagaa aaatatggac gaactagaag acatcctaaa attactttca tctataggtg
    12121 ctaattctgt aaagtttaat attctccaaa cagtaggacg gggagaaaat ttagatagat
    12181 taactagacc agatatgatt aatatacata aaaggataga aaattatact aaagaaaatg
    12241 aatctatgga aatcgataca agtgctccta tgtgtacagg tttatattca ctaaataatt
    12301 tttattaccc aaaatcatct aaaggatgta attttggctc agtttgctgt ttaactcctg
    12361 gtggtaatat ttcattatgt ggatggagca agtcaaagaa agattctgaa cttctattag
    12421 gcaacattga aaatgaaaag cttaaggata tatggaaaag aaaagagttg gttgtcaaga
    12481 aaactgaacc attagaaggt gtttgtaata attgcctatt cttaaaatta tgtaaaggcg
    12541 gatgcagagc catagcttat gaagtatatg ggaagttaaa tgctcctgat cctatatgtc
    12601 aggttatgta tgaagaaggt gagtttccaa aatcaaaact tatcgctaat taataattat
    12661 aatcaagtct atatttttct tgtataagga gaataacata aaatgaataa attaaaagaa
    12721 aagaaaaaaa agagaaagtt ggaatacaat acttttaata caataatata tttattcaaa
    12781 catatatggt tatgggataa gccattaata ttttatttct taatatattc aataactgct
    12841 ggaataatac cttttatagg tatttttctt cctaaaatga taattgatga attagttgga
    12901 cttaagagaa ttaacatact agtaattata attgcttcat tttgcatagg agggttatta
    12961 ttaaatctta taaaagttta ttcacaagaa gtatattggc caagagtaat tcaaatccga
    13021 atggagttta ttcataaaat tgataaaaaa gctatgacta tggattatca acaattagaa
    13081 agagtaaata ctaaggactt aatacagaga gcttggatgg cactgtcagg taatgatata
    13141 ggggtcgaag gaattcttaa tcaaatattt gttttatttg gtaatattgt tgcctttgga
    13201 ggatatatag ctataatcag tactttaagt ccattaatag tattttttct gatattaact
    13261 gtaggtatta cttataaagc ttctctagga gaaaaaaaat attctcatca agtagataga
    13321 caaatggcta taaatgaaag aaaactaaaa tatctggata agaaaatggt aaatcatagc
    13381 ctagctaaag atattagatt atatgatatg gcaaaatggt tgactaataa atatattact
    13441 tggtgcaatg agatatattt aaaattaaaa aaaatagcta tcaaacgatt taaaatagat
    13501 acgttacaag gtttcttatc ttttgttcga aacggtatag tatatgtata tctaataaat
    13561 agagtattat acaacggtat gagtataggt aattttacaa tgtattttgc atctattcag
    13621 ggtttttcag gttggatgga atctgttgtt agttctatat tatctattag acagcagaat
    13681 ctctatataa acgattatag aaattttgtt gatgctaagg aacctaataa aaatgataat
    13741 agagattcaa tgaaaaaaga tattagtgac agggtatata agataaaact agaaaatata
    13801 ttttttaaat atcctaatag tgataactat actatcaaca atgtatgcat tcatgtaaaa
    13861 gatggagaga aagtagctat agtaggagct aatggtgcag gtaaaacaac attaattaag
    13921 atacttacag gtttgtacaa acctactaaa ggtaaagttg ttgttaatgg aatagatagt
    13981 actaatattg ataaaaacga gtattttaaa ttattctcag tagtatttca agatattaag
    14041 ctatatgctt tttctcttgg cgaaaatatt tcattaagga aaatagatga aactgataga
    14101 cagaaagcta taaactgtct taaatcagct ggtttatcag ataaattaaa aaacttagaa
    14161 aatggtattg atacaagctt attaaagata ttagatgaag aaggaattgt attatctgga
    14221 ggtgagattc aaaaagtagc tttagcaaga gcactataca aagatgcacc aatacttgta
    14281 cttgatgaac ctactgctgc tttagatccc atagcagaac atgaattata tgaacaattt
    14341 gatagattga caaaaggtaa aacagcaata tatatttctc atagattagc aagcacaaga
    14401 ttttgtgaca aaataatatt gttggataaa ggttctataa aagaatatgg tacacatgag
    14461 caattaatga aaattaatgg gacatatgca aaaatgtttc ataaacaagc tcgctattat
    14521 aatagtgata tcaaggatca taaagaggtg ttggcttaat gaagaaatta tataataatt
    14581 taacaatgga attcaatgtt atttttttta tattaaagct aacaaatgaa tattcaaaag
    14641 cttttttgcc tttaacaata ctattggcac ttattagttc ttttttaact atctataatc
    14701 tgttaatgtc cagaaagatt atagatgagc ttatactagg aaaacaattc aataaactat
    14761 tggaaataat tattttgcta ataggtgtaa atttacttat gcatataata agaagtatta
    14821 tttttagatg gctacaagca aagaaccaat ttataaaaaa aagatttaac ctagaaataa
    14881 ataaaaaaac aatgtctatg gattatgaat atgtggaaaa tcctaagatt ctagatgcaa
    14941 aagaacgtgc actcagcggt ataaatcagt cagggggcat taatactttt acaaacaata
    15001 ttaggaacat tattacatgt atttgtacca taatggggtt attatatatt ctaaatgatt
    15061 taagtatagt aatcatatta atacttatta taatgataat atttaactac atagctgaaa
    15121 gcaaaagaca gaaagcggaa tatcattctt ggcagaagaa tgctaaaaat aataaaatgt
    15181 tttcttatct agatggagaa gtaataaaag attataaggc tagtaagtat ataagactat
    15241 atgattcgtc tgagatgata cttagtagat atagacagtt tgataaaaaa tctcagagac
    15301 tatttagatt gatttcttcg tcgaataaaa agcattatct tattattaat atattagatt
    15361 atagtcaaaa attcataata tattttactt tggctctaaa agtgataagt gaaccttcta
    15421 aatttacaat agggtctttt actatgtata cttctgcact atataattta attagctcaa
    15481 taactaaaat gtttaaatca gcggttaaaa taaaatatac ttgtaaatat ctaaaactat
    15541 ataaagaatt tattgagtta ccaccaattt tatgtaagaa taacgaacac atacctgcta
    15601 atactaacta tagttttgag tttagtaatg tatcttttgc ttatccagga atgaataaac
    15661 tagtactgaa gaatattaat cttaagatac catcaaagca aaaactagct atagtaggat
    15721 tgaatggtgc aggaaaaact acttttatta aactagtgat gcgattatat gaccctaaaa
    15781 atggtgagat attattaaat gataataata tcaagaagta taattataga gagtatcaga
    15841 atttatttgg agtagtattt caagacagta atattttatc atttactgtt aaggaaaata
    15901 tatgtttgga aaatagtagt tcaactcaaa atgatatagt tattgaatgt ctaaaaaatg
    15961 ctggagttgg agataaaata gatgtcttag aaaatggagc agatacttat gtagatagaa
    16021 tatttgatga taaagggatt gaattttcag gcggagaaat gcagaaaata gccattgcac
    16081 gtgctatata taaaaatgca tctataatga tatttgatga gcctacagca tcactggatc
    16141 ctttggctga atacgaaata ttcaatacgc tacatgaatt aacttatgga aaaactgcag
    16201 tttttatatc tcatagactt tcgagtactc ggatatgtga ttgtatagct gtcttccata
    16261 atggagagat catacagtat ggttcacatg atgaactcat gaaagataga gagggcaagt
    16321 attataagat gtttatggct caggcacaat attatgtgag taacgatgaa gtaagttgta
    16381 tttgaaatat ggaaaaacat aatttttgta aataaggatt aattattctt gaccgtgttg
    16441 atccttctat gttatctaca tatgaagctt tgacagaacc aaagtgggct ggaaaagtac
    16501 tggtaagaag ttcaagcaat atatataatc aatcattatt agcatcattt attgccctaa
    16561 atggagaaga agccgatgca gaatgggcta aaggcttagt agcaaacatg gctagaacac
    16621 ctgaaggtaa tgaccgtgat caaatgaaag ctgttgttgc aggagaggga gatgtagcaa
    16681 tagttaatac ttattatgta ggaaaattat taaattcatc tgatgaatat gaagttgaag
    16741 taggaaagaa gattggagtg tatttcccaa atcaagaaac aacaggtaca catattaaca
    16801 tcagtggcgg agcattaacg aaacacggaa aaaatagtga gtcagcaata aaattattag
    16861 aattcttgac aggtgaagaa gctcaagatg actatgctaa tgctaactat gaatacccag
    16921 taaatcctaa agttgaacca tctgatttat tgaaaagctt tggtgatttt gatatacaag
    16981 aaatagattt atcccttcta ggtgaataca acgatgaagc tgtaaagatt ttcaataaag
    17041 ttggatggca gtaagcttat gagaaatgta atgaaaggaa ggcgaataag tcctcttcat
    17101 gtcattgcaa gtatcataat tatgctgata cttttaccaa gcttaatgat agtgattcaa
    17161 ctatttcaac ctgtgacaga atcatggatt catattaaaa catacctatt aaaagactat
    17221 ttaataaatt caataaccct tatttttctt gttggagggg ttacatgttt acttgggatt
    17281 tttttcgctt ggtcgttatc aagatatagg tggaaatata cgaaaacact agaaatatta
    17341 ttgtttttac caatggcgat acctccgtac attggaggat atgtctatgg gggtattttt
    17401 actagttttg gaacactcca tcgtataatg ttgactcttg gattgaaacc tataaaaatt
    17461 gatatcttat caatgggagg agcagtttgt gtttttagtt tgtttttgat gccttatgtc
    17521 atgttggtaa caaaaggatt ctttaatcgc cttcctaaaa atatagaaga atcctctaga
    17581 ttattaggta aaagcagatt ccagacgttt tataaaatta tattgccaat gagcagaggt
    17641 gctatcatag gaggagttat acttgttgct ctagaggtac tcaacgatta cggtttagtc
    17701 aagtattttg gtattccaac ttttagtact gcaatctata ctacttggtt tggtttgtca
    17761 gatgtggacg gagcaatcag acttgcttca agtctcatga ttatagttat catcatttta
    17821 ttggttgagc aattcttcag aggtagaggg agattaagtc aagcaaaagc tgttccagat
    17881 ttaggtacaa agaaggcagc accaatagga tataaaatat tattttatat tgtaggaact
    17941 atctatctgt tactaagtct tattattcca gttgctcaat taatacactg gagtacttta
    18001 gcaaaggata cagtggtact tagaaacctg gataaaatat taaaaaatac cttgattaca
    18061 gcaatcattg ttactatcgt aataatcatc tgtagtagta taataggaaa tcttaatcgc
    18121 ctacattctg gaataataac aaaaatatat gctcgaattg tcattgttgg ttactccatt
    18181 cctgcatcaa ttatagcaat agccgtactt gtgtttttta tagctgctga taggaatttg
    18241 ggtggaatat atggattttt tggattgaaa aacctgtttt tgacaagcag tgtatttatg
    18301 ctgatttttg cattgaccat tagatttatg gcaataggtt ataacagcgt tgaatcgggt
    18361 tttagcaaaa tgggattaaa atattatgaa gcatcaaaac tattgggaaa aggggagtgg
    18421 cataccttta caaaagtcga cctaccaata ctaaaacctg ctataattag tgctatgata
    18481 ttaacatttg ttgatgtatt aaaagagctg ccactcacat tgatactgag acctttcaat
    18541 tttgatacac tagctactaa agtatatacc tatgcaaatg atgagatgat acatgaagga
    18601 agcatctacg cattgatgat tataggtgta agtaccctag cactagtatt tttattagga
    18661 ttcaggaagg agaaggcaga atgattgaat gcaaggacat atcctttaga tatagtaatg
    18721 ctattgaacc tacattaaat aaagtatcat tttcattaca taatggtgga gttttagcag
    18781 tagtaggacc tagtggtgga ggcaagtcaa cattacttcg tgttatagct gggcttgaga
    18841 caccatatga gggtacatta agcattaata ataaggttgt ttttaatgtg aataataatg
    18901 tgaaaccaga aaatagagga ataggtatgc tttttcagga ttatgcacta tttccacata
    18961 tgactgtaaa gaaaaacatt gaatatggga ttgatcatct accaaaaaaa gagagaaaac
    19021 aacgacttga tgaagtatta gagttagttg ctttgggtgg ttatgaaaaa aggtatcccc
    19081 atgagcttag tggaggacaa cagcaacgta ttgcgcttgc aagggcattg gctccaaaac
    19141 caaaattatt attattagat gaacctttta gtaatcttga tacccactta cttaaaaagg
    19201 ttagagatga tttgttcaat attataagga aaaccaatat aaccacaatc atggttacgc
    19261 ataatccaga ggatgcaaaa gctgaggcgg ataaaataat tagcatagtg gatggtagga
    19321 ttgataggga agttatgaat atgaaagatt agttgttata gatgatttat ataaattaga
    19381 taggtaattt aacttgtgaa gagcagagat tattccctgc tttttttgta tgtttatgga
    19441 tttgtaatct gttatattat caacaaatgg tatagtataa tttgttgata atgtttaatt
    19501 tagaagatat atatacgttt ttttgatttt aacactaata ataaggtggt attaaacaat
    19561 atgtatttat tttatttata ttatggtata atatagataa aaaaaaggga tagaaaatta
    19621 atttaataga aaatagatgt tgattttggt taaattataa ggagacttta aaatgaaaaa
    19681 aataagtata atcatagtaa ttttaatatt tataattgtt gcattaaatc aaattatagg
    19741 agataaagat ttgataatag ataaaataaa agatacaaaa tcaaataaag atatagtact
    19801 tctttttgat gaagagaaaa taaatttaca atttgataat aaagaagtag gggttaagtc
    19861 aatacccaaa gatttgatag atgattatga gtatagttta aagataattg gaaattatct
    19921 attagttgga atgataaata agaagacagt aaaatatagt tcattaacat ttttgtatct
    19981 ttatgactac attcaaaatc cgataactaa aatatggtct acagatgatg aattaaagaa
    20041 agagcttttc cttaaaaact ataatactac taacaatacc attattgttg atagtgattc
    20101 atcagaagtt attattgagt atgatgaaaa aatagaaaat aaattaatgg aatttatcaa
    20161 atcaattaaa gaaaaggata aaaagataca attagaaatt agtaatacag tagcgtattg
    20221 tatatatgat tatgataaag atggacaaga agagcttatc actaaatcta tagttacaat
    20281 gggtttttct cccttagtag acacatacta ttcagtatat aaaattgaag ataatggtat
    20341 acaaaaagta aaatcatgtt tttatagtaa agataataca ctagagaaat attttaagaa
    20401 ttttaactaa tttataaaaa atatattgaa taatactttt aatagtatca ttcaatataa
    20461 gattttaatt cattttttaa aaatgctaat cctttttctt cgtatttttt tattgttggt
    20521 cttgttaggt taatttttct tgatatttca gtataggttt tttgttcaaa aaacttatac
    20581 tgaatgattt tcctttcctt ttttggtaaa agatctattg aatgattgat atctattttt
    20641 atatctgtta tttcaccata atctttaata aggttattat atttttcatt acaaaaatct
    20701 acaattattt cattgttttt tatctttata tcttttttta gtaatttaat atatccataa
    20761 tataaggagt tagagaagta ctttactatt tttgcatcac cacttaaatc aggtatttta
    20821 tatattgatt taattagata tattattaaa tcagattgtg cttcatcata ggataatttt
    20881 ctagcatatt tattaattaa tggattaaaa ctgttaatta tattaataac tattttttcg
    20941 ttttgtgttt tatcttgaga ttgtttaaat gttaatatta attctgtcca ttttgtttcc
    21001 ataatagtag atctcctttt aatataatat aagaaaattt gttttcatat agtataaaag
    21061 agccttttaa atcaaaaaat gtaaaataat attttatttt acatttttta ttatattagg
    21121 ctctttattt gttgtaataa aaattaaatt atatttatag gaggttattt catgaaagat
    21181 tcaaaaatta aaactttact actttcgaca ttattattga caattatttt tacatcatct
    21241 tggtcgacct atgcagaaga aattaactat gaaaaggtgt gttctttcca agaagtagaa
    21301 catgaatgga ttggtgacta tactggtgaa tataatcgac cacgttatct aagatatgaa
    21361 gcttatgata agatgggaaa aaaaattagt tctagtcaag taagtagctt atctaatgta
    21421 gaaaaagtag cacgaactat cttaggagaa atttgtaatg ttcctcctag aatagataat
    21481 gcttatgctg tagcacaagc tataaagaat agaatggatt atgataataa aacagcagtt
    21541 caagtaattt cttcaggatt tgatgcttat ggtggaggag cttttaaaga tcctttaaat
    21601 tattattatc tagaagatga atatcgtctt tgggcggaat gtgcatggtt agctgcatgt
    21661 ttagttgaag gtgatagtat tccaacaagt ggatatgatg atattggtaa tagtagattt
    21721 tttggagata tttctgtttc aagttatctt aagagattta agttaagcaa tggaactact
    21781 tgtaatgaaa caaatattga gtctgcaaca acctttgttt gttggggaag aaaaaatcct
    21841 atattaaata ctgtgaaaaa gtttggaaat catgtttatt ttgaggttaa tgatagataa
    21901 aattgacata aactaatttt attataagtt acatatatca aaagagatta ctttgccatt
    21961 aatgtaaagt gatctcttta atattattct ttttcttatt taataaatat tataatggaa
    22021 attcttaata actaaaatga tgataaatta gttgaagtat ctttgcttga ataattgata
    22081 tatataatgt agaatctaaa catattagat acctatattt taatatttaa aatatactaa
    22141 tgaattattg tagatttaaa tctagtaatt tgagtttata agtactaatt tattaagggt
    22201 gattatatga cagaagaata aatactaaag ataattaaaa tgaaagctca aatttataga
    22261 gagcagggtg tagttatttt aattacagta ccaaatcaaa ctgatataaa tattttactg
    22321 catttgatga tgtgttcatt acaacaagag attactcgga tttttcaata gacctatacc
    22381 taggtgaaaa taaaaatcgt acagaaggtt ttataactaa tatagtatca ttaagtaaaa
    22441 ctgaaagtat tgtgaaaggt attgttgttg gtgactccat ggataaagtt ctaactactt
    22501 tttttagtga agataatgaa ccaatttctg atgattatta tggtgatatt aagattctct
    22561 atggtgatga ggatctctat aataaatgtg cttacataat ttataaagat gatacacctt
    22621 ctataattaa atatgttgga gagactgtgg tat
//
