LOCUS       NZ_CP058561            21443 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Vallitalea guaymasensis strain Ra1766G1 chromosome, complete genome.
ACCESSION   NZ_CP058561
VERSION     NZ_CP058561.1
KEYWORDS    RefSeq.
SOURCE      Vallitalea guaymasensis
  ORGANISM  Vallitalea guaymasensis
            Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
            Vallitaleaceae; Vallitalea.
REFERENCE   1  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Vallitalea guaymasensis genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2020) Microbiologie Environnementale et
            Biotechnologie (MEB), Mediterranean Institute of Oceanography (MIO),
            UMR 7294, 163 avenue de Luminy, Marseille 13288, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. JUNE-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141425.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:20:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,859
            CDSs (total)                      :: 4,781
            Genes (coding)                    :: 4,757
            CDSs (with protein)               :: 4,757
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 7 of 24
            Pseudo Genes (incomplete)         :: 16 of 24
            Pseudo Genes (internal stop)      :: 1 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2542810
            Orig. end                         :: 2564253
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058561.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21443
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="6"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21443
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21443
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11443](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11443
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     gene            175..645
                     /gene="accB"
                     /locus_tag="HYG85_RS11205"
                     /old_locus_tag="HYG85_11120"
     CDS             175..645
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accB"
                     /inference="COORDINATES: protein motif:HMM:TIGR00531.1"
                     /locus_tag="HYG85_RS11205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11120"
                     /product="acetyl-CoA carboxylase biotin carboxyl carrier
                     protein"
                     /protein_id="WP_212693513.1"
                     /transl_table=11
                     /translation="MKFENIKELINLVSDKGLTRVDIEKDGCKISIRKEKEVLMTSNPE
                     PYVQKPNTSQTVNVNKETVQENDSHKVEVEDENTVTIKSPIVGTFYSAPSPDEDDYVKI
                     GDKVSKGKTLCIIEAMKLMNDIEAEVSGEIVDVLVENEEIVEYNQPLFKIRP"
     gene            715..1137
                     /gene="fabZ"
                     /locus_tag="HYG85_RS11210"
                     /old_locus_tag="HYG85_11125"
     CDS             715..1137
                     /EC_number="4.2.1.59"
                     /codon_start=1
                     /gene="fabZ"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1270: UDP-3-O-[3-hydroxymyristoyl]
                     N-acetylglucosamine"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008397742.1"
                     /locus_tag="HYG85_RS11210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11125"
                     /product="3-hydroxyacyl-ACP dehydratase FabZ"
                     /protein_id="WP_113673054.1"
                     /transl_table=11
                     /translation="MLDAVEIQKIIPHRYPFLLVDRITEMEPGKRAIGYKNVTMNDYFF
                     AGHFPEEPVMPGVLIVEALAQVGAVTMLSLEEYKGKTAYFGGINKTKIRRKVVPGDRLD
                     LEIDIIKQKGPVGVGKVVASVDGEIAVTGELTFIAK"
     gene            1171..2514
                     /locus_tag="HYG85_RS11215"
                     /old_locus_tag="HYG85_11130"
     CDS             1171..2514
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016874 - ligase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dala_Dala_lig_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090: acetyl-CoA carboxylase biotin carboxylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009203701.1"
                     /locus_tag="HYG85_RS11215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11130"
                     /product="acetyl-CoA carboxylase biotin carboxylase
                     subunit"
                     /protein_id="WP_212693514.1"
                     /sec_met_domain="ATP-grasp (E-value: 3e-07, bitscore: 28.3,
                     seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Dala_Dala_lig_C (E-value: 1.7e-11,
                     bitscore: 42.1, seeds: 12, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFNKILIANRGEIAVRIIRACREMNIQTVAVYSDIDKEALHTQLA
                     DEAICIGPAPAKDSYLDIKRIISAAIVTGANAIHPGFGFLSENSKFAKVCEECNITFIG
                     PTGDMMDRMGNKSKARETMIENNIPVVPGSEGAVDGIDEAIELADSIGYPVIIKASAGG
                     GGRGMRIANSREELVNSYKTASAEAKSAFGDDTMYLEKYVTNPRHIEFQILADNYGNTV
                     HLGERDCSMQRRHQKVLEESPSAAIDDELRKRMGKAAVKAAKAINYKNAGTVEFLLSDS
                     GEFYFIEMNTRIQVEHPVTEMVTGIDLIKEQIRIADGEKLNYTQKDVKIEGHAIECRVN
                     AENPSKGFRPSPGEISFLHMPSGKDIRVDSAIYCGYKIPPTYDSMIAKLIVYDKDRKSA
                     IKKLNSAIGEFIVEGIDTNIDFQYDLINNESFVKGNYNTSFIEKLMEK"
     gene            2773..3645
                     /gene="accD"
                     /locus_tag="HYG85_RS24770"
                     /old_locus_tag="HYG85_11135"
     CDS             2773..3645
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="accD"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009203702.1"
                     /locus_tag="HYG85_RS24770"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11135"
                     /product="acetyl-CoA carboxylase, carboxyltransferase
                     subunit beta"
                     /protein_id="WP_113673056.1"
                     /transl_table=11
                     /translation="MKELFKKKKYIKLPIKTAVNGKEQYNDMSDPSVPTGKWIKCNNCG
                     EIIYRDDFEAKDQICTKCHKHFRMDSESRISQIIDSGSFKELNTNMGTKNVLDFPEYLE
                     KISSLQKKTGLKEAVVTGEGKINGIKVVIAVMDSRFMMGSMGEAVGEKVTRAIEHATDK
                     KLPIIIFTASGGARMQEGIVSLMQMAKTSSALAKHSEAGLLYITVLTDPTTGGVTASFA
                     MLGDIILAEPGTLIGFAGARVIEQTINQKLPEGFQKAEFLLEHGYIDMIVERRDMKNTL
                     FKLLEFHQN"
     gene            3730..4518
                     /locus_tag="HYG85_RS24775"
                     /old_locus_tag="HYG85_11140"
     CDS             3730..4518
                     /EC_number="6.4.1.2"
                     /GO_component="GO:0009317 - acetyl-CoA carboxylase complex
                     [Evidence IEA]"
                     /GO_function="GO:0003989 - acetyl-CoA carboxylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006633 - fatty acid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR00513.1"
                     /locus_tag="HYG85_RS24775"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11140"
                     /product="acetyl-CoA carboxylase carboxyltransferase
                     subunit alpha"
                     /protein_id="WP_113673057.1"
                     /transl_table=11
                     /translation="MNPWEKVSIARMAERPTSEDYIRLIFDDFIELHGDRLYSDDKAII
                     GGIGLLEGIPVTVIGQQKGRSTKENIDRNFGMPHPEGYRKALRLMKQAEKFNRPIICFV
                     DTPGAYCGLGAEERGQGEAIARNLFEMARLKVPIISVVIGEGGSGGALALAVSDRVWML
                     ENSIYSILSPEGFASILWKDSKRAKEAAEVMKITAEDLLELGIIEKIIEEPDGGAHNSY
                     HQISAELKDSFIKELEILNGLDEELLIENRYNRYRKQIKE"
     gene            4699..5805
                     /gene="pdaA"
                     /locus_tag="HYG85_RS11230"
                     /old_locus_tag="HYG85_11145"
     CDS             4699..5805
                     /GO_function="GO:0016810 - hydrolase activity, acting on
                     carbon-nitrogen (but not peptide) bonds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="pdaA"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1235: polysaccharide deacetylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR02884.1"
                     /locus_tag="HYG85_RS11230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11145"
                     /product="delta-lactam-biosynthetic de-N-acetylase"
                     /protein_id="WP_212693515.1"
                     /transl_table=11
                     /translation="MAKKKKKDTKTLKALAIFVLVIGAVYLGLTVGKGAFKPDTTAKDD
                     NENNTIAKEENDNKGKTDNELDETNTESEIHPEKEVKPESEEKSETEEPKVTEEEKDSE
                     EENPSDQEDIKEEDNGEIPQGSSTEDNFDMNVDASTLSNKGYSWSFKRNKEHKKVIGYN
                     KFDIKQYGGYYIVDTDEKVIYLTFDEGYENGYTPTILDTLKANEVKATFFVTKPFIENN
                     AELAKRMKDEGHIVGNHTVHHKRMYELTDDEIKYEIEETARYFEEMTGYKMDTFFRPPE
                     GAYSERSIYLTRELGYKTIFWSMAYADWDTNNQKGKEYAYNHVINNAHPGMISLLHAVS
                     SSNTEALDDIIKTLKEQGYRFGNLYEIE"
     gene            complement(5890..7608)
                     /locus_tag="HYG85_RS11235"
                     /old_locus_tag="HYG85_11150"
     CDS             complement(5890..7608)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="HYG85_RS11235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11150"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212693516.1"
                     /transl_table=11
                     /translation="MNNFGILKKVIKLLKPYKFKFFLIMLCVIMLTVVSIINPLIIKNI
                     TDDGLLQHNLSTVIKMSLILLLLAVSQGILTLIQETIRIKLQNNIVYTLNKKTFLKLSR
                     VKIEEIRDINDTDLFNRIYTDINNISRVADKNILFITTQIFTIIGSCVGLFLISWKLSL
                     IVLSIAPIKFFCAKYFSKLRMKYEKLFINKSSEFANWYGDVIAGIKDVRLYGLINTKLI
                     ELKSKQKELIHIRQKLNILSEINMVTESISIQTLISILYIVGAIFLIGGELSYGSIIAL
                     ISYSIKVTSPLSAIMNIGYYLTGIIPSARRYFDFMDLENEMEANTHKNITHNCLPTKHP
                     ILTFKDVSFAYDNNNTVVSNIDIEIREGEKIAFIGDNGSGKSTMLNLLLRFYTPNNGKI
                     LLYNTDINYYPIDEYRQHFATVMQNSHLFQNTIKDNIVLDKKISNDMFDNIISMSELSD
                     FYNTLPDSYMIGQNGSCLSGGQSQKIAIARAIAKDSKIFILDEATSSLDIRSEINISKL
                     INSHLVNKTVICVTHRPELLKYMDRIILLDKGNITQIGTHDELLQLSQLYKKIIS"
     gene            complement(7629..9203)
                     /locus_tag="HYG85_RS11240"
                     /old_locus_tag="HYG85_11155"
     CDS             complement(7629..9203)
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012311.5"
                     /locus_tag="HYG85_RS11240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11155"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_212693517.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 3e-16, bitscore:
                     57.7, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVEIYTRHIMSNKLRVAIIDDGIAKCLPGELINKNIEINSNNIL
                     LQSNGEDKLTHGTICASIIEKYAHNISSISSIKILDHNGNGNITQLYTALEWCIQYNIN
                     VVNLSLGSIYFDDMQSIRKIVNRCASLNIILVCAASNSDFITYPSSFSNAIGVSCDYNN
                     IYDLSKNQYYMLNNKYQNGIDIVAYSEHKLYNPITHNYYTSDKCNSFATPMITAKICNM
                     ISEDNNININTLLNKLKNDAVNDCKNENRIKNYLYIDWIIKAIIIDIDYDEKTSWDYYF
                     DIILHLSYSTMNIESIMNKIANYTFDTLIIRAKTPINIHQESLDSLLSLEKNIVLININ
                     PEHNYDKINAHMLWHNQLKYNAILNNSHQSHNAILNIPNLCIFYDKNIDVIMFSCYLRE
                     CFGKKGYNINLINDEASCILYDIDYIPLDCIRNDHKKAIDYISYFTFLANYDLNIWFSS
                     NDNKDYYNKILSQLKYDIIIEINMIHYNNIILSVLTDNQQKYSLTFESLTKKNIESFFD
                     LLIKLLS"
     gene            9543..9725
                     /locus_tag="HYG85_RS11245"
                     /old_locus_tag="HYG85_11160"
     CDS             9543..9725
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04065.1"
                     /locus_tag="HYG85_RS11245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11160"
                     /product="CLI_3235 family bacteriocin precursor"
                     /protein_id="WP_212693518.1"
                     /transl_table=11
                     /translation="MKKLGKKVMKTGNTIKAHMYCMCNSCGCYCNCWGDESASHSSFYS
                     SQSSSSSSSYYSRVN"
     misc_feature    9579..9595
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: weak, score: 19.91"
                     /tool="antismash"
     misc_feature    9845..9863
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 27.26"
                     /tool="antismash"
     aSDomain        10001..10378
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYG85_RS11250_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="1.70E-15"
                     /identifier="RREFam021.1"
                     /label="HYG85_RS11250"
                     /locus_tag="HYG85_RS11250"
                     /protein_end="126"
                     /protein_start="0"
                     /score="48.1"
                     /tool="antismash"
                     /translation="MQNDALPFIHLFKTYENTYVFDINSNAIFKIPKYVYDDLEHYLNN
                     KKITFSCDKSKEIIEMMMTNGLLSSHKWKYMEHPSTSIIPQYLKTSVSTLTLQITQACN
                     LMCNYCPYAGSYHNRKHSSKKM"
     gene            10001..11443
                     /gene="ccpM"
                     /locus_tag="HYG85_RS11250"
                     /old_locus_tag="HYG85_11165"
     CDS             10001..11443
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0030152 - bacteriocin biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0046500 - S-adenosylmethionine metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="ccpM"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR04068.1"
                     /locus_tag="HYG85_RS11250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11165"
                     /product="Cys-rich peptide radical SAM maturase CcpM"
                     /protein_id="WP_212693519.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     2.9e-13, bitscore: 48.1, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 3.1e-59, bitscore:
                     199.0, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 9.6e-16, bitscore: 56.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 3.6e-08, bitscore: 31.9,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 8.6e-08, bitscore:
                     30.6, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQNDALPFIHLFKTYENTYVFDINSNAIFKIPKYVYDDLEHYLNN
                     KKITFSCDKSKEIIEMMMTNGLLSSHKWKYMEHPSTSIIPQYLKTSVSTLTLQITQACN
                     LMCNYCPYAGSYHNRKHSSKKMSFETGKRAIDFYVKHAVDVESLNIGFYGGEPLIEFDL
                     VKRLVEYANDTYKGKKIRYHMTTNATLLKDEIIKFLDDNNFNLLISLDGPKEIHDKNRK
                     DSQGRGSFDRILENLKYLQQNYKDFASKINFNCVIDPSLDFDCLHKFFTDYDTVKNYYT
                     SFNYINKQNIIEDKFNPTENYTIKYKYEIFKLFLFLIKRLDERHVSKIVKSYYSVLFST
                     MKERRTVSFSETEYGHHSGPCIAGSHKIFVDTEGNLFPCEKVNEQSKSFIIGNIWDGFD
                     VEKASKLTNIGKLTEKQCLSCWNVNFCYLCCVFSDDNGTLSANAKLTQCKNLKRDTEEM
                     MKDYCYLKEMDFTYDDEVFRII"
     gene            11464..12570
                     /locus_tag="HYG85_RS11255"
                     /old_locus_tag="HYG85_11170"
     CDS             11464..12570
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR04066.1"
                     /locus_tag="HYG85_RS11255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11170"
                     /product="TIGR04066 family peptide maturation system
                     protein"
                     /protein_id="WP_212693520.1"
                     /transl_table=11
                     /translation="MKEAILFPYDISNIHLLMHQDMLSDFRISGVVSPNSWGYADEDAG
                     RILGIDTGYMVRSSFEGLIDQCECVLFCESYLELPYESFLKEYIEYIAQKGKKLIFLGE
                     YEQHCEEIKDIAKHYNAEYEFIIKKDDKKYEEMYCYKMKDIPVPIITVIGTNERTNKFD
                     TQLSVGKFFREQGYKVLQIGTKGYSNIFDMIAYPKFMYNQELSTTNRIQQFNYYIHSLC
                     IEQKPDVVILGVPGAAFPMDNKFHNNFGFHNYLVSNAILSDYTICSIPYEDYKEDYFNY
                     LSTHIKYKYGYNINCFIIANQAIKWDETDNSEKIQYLTLDKETMNRKCRHYLDKNYPVF
                     NIFDSKLNTMLTHSILDELYSNSDEELM"
     gene            12590..12838
                     /locus_tag="HYG85_RS11260"
                     /old_locus_tag="HYG85_11175"
     CDS             12590..12838
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS11260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_11175"
                     /product="hypothetical protein"
                     /protein_id="WP_212693521.1"
                     /transl_table=11
                     /translation="MTDNNIKEQIVNLINTVKGINLKEEDYDEHLFSSKIDLSPRDLVY
                     VFLKIEELFKTKIPEENIINEDFITINKITEIVSSVR"
     gene            complement(12915..14201)
                     /locus_tag="HYG85_RS11265"
                     /old_locus_tag="HYG85_11180"
     CDS             complement(12915..14201)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014826.5"
                     /locus_tag="HYG85_RS11265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11180"
                     /product="PHP domain-containing protein"
                     /protein_id="WP_212693522.1"
                     /transl_table=11
                     /translation="MKEELRFFEVTPKIILADTTAEIEIKPLAKYATFDSDTDIEVAYY
                     PLEHFSTIGEYNYQEKYMVRAKDGVIQLTQYFIGEQEHIIKITDTATKKSYTFNFYSVR
                     ADLFDRIPYKGDLHMHSHHSDGKESPGFVTASCRKIGFDFMALTDHGKYYPSIECQETY
                     KDIDLDILIARGEEVHPENNNVHIINFGGDFSVNEYMQDNKDEYYKEVKEIEKTINLDD
                     EHAKYECASSMWCFDKIREGGGLSIFCHPYWLIDSGYYISNSVIDFMYDNQPYDANEVV
                     GGYHPFEFSSNTLQIARYYEERAKGKKVPIVGVSDAHGCENKDLFGWFYTIVFAPSNEQ
                     PDIIKSIKDLYSVGVEFPAGETVRPVGPFRLVKYALFLIREVFPLHDELCYEEGQLMLK
                     HISGDENAKVRLNSLKGQVSNLYNKLFSK"
     gene            14468..15733
                     /locus_tag="HYG85_RS11270"
                     /old_locus_tag="HYG85_11185"
     CDS             14468..15733
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1106: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.5"
                     /locus_tag="HYG85_RS11270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11185"
                     /product="MFS transporter"
                     /protein_id="WP_212693523.1"
                     /transl_table=11
                     /translation="MTKLSKSQIRIFILCWVAYASIYFGRVNLSVAIPQIQDTFGWSKG
                     SMGLIGSLFYWVYGFGQLINGQIGDRISTRRIVFFGLITTAICNICFGFSTTYIFMMVL
                     WIINAYAQSTLWGPIVKSITNWYEPKKRSSVSIGISTSMVGGYILAWGGSGLIIAKSHW
                     NLVFWVPGIIILIYSIIWFSFFRDTPKEASKYISDEPTEGATVKDNKYSLLQVIIESKL
                     IYIVLACFVQGIIKDSIALWAPTLFMETQNLDITETTQFIIFIPVMNLLGMMFASFLNK
                     KLKHKEKRTIYILFLISIFMIIGFVKLGSYNIIIALIFLGLTSAVMYGANTLLLGVIPL
                     HFAKYNKTSSIAGFLDFCSYLAAGFAAFITGALVDRFSWNGVMIFWIVCLVVGIFALLM
                     SLKCDKIAVKMEKVTDNTYLID"
     gene            15748..16509
                     /locus_tag="HYG85_RS11275"
                     /old_locus_tag="HYG85_11190"
     CDS             15748..16509
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012669.5"
                     /locus_tag="HYG85_RS11275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11190"
                     /product="DeoR/GlpR family DNA-binding transcription
                     regulator"
                     /protein_id="WP_212693524.1"
                     /transl_table=11
                     /translation="MLAEERYKIILDLLEKNNSVKSSYLIELFGVSVETVRRDLEHLEK
                     EGFLHRVHGGAMLDQINPKSIDFKIREKSHNQEKVNIAQNAMGFISEESVIALDNGTTT
                     LEIAKLLKNKYKKLTILTNSILVVEELVNEPDYTIILLGGIVNTKDKSLKGELVENYIN
                     LFHIDICFISVSGISLKEGATEFEIDTIPIQKRLIERSGKKILLADSSKFGVVSLLKVC
                     DLNDVDHIITDSNLKEAIYERYKAKGIDVIK"
     gene            16692..18131
                     /locus_tag="HYG85_RS11280"
                     /old_locus_tag="HYG85_11195"
     CDS             16692..18131
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012562.5"
                     /locus_tag="HYG85_RS11280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11195"
                     /product="glucose-6-phosphate isomerase"
                     /protein_id="WP_212693525.1"
                     /transl_table=11
                     /translation="MSKRFEQKDWQESMRLKLDFNNMMTSYVGENGISEEEIADLQAQI
                     EKAEKAMVEKRANGGMDWRDLPYNQADIVKDINAYVESVKDDFDTFVVLGIGGSALGPI
                     AVQQAINHPYYNELSKEKRGGYPKLYVMDNIDPEKLVSLFDIIDLDKTLFNVITKSGST
                     SETMSQFMIIKEMLEEKLGKEESKKHVVCTTDAKNGNLRPIADKEGYKSFIIPAGVGGR
                     FSELTPVGLLPAAMCGIDIEEILAGAAYMDELCKTDNTFKNPASMYAILNYLAMRRGKN
                     ISVIMPYADTLKYIGDWYAQLWAESLGKKFDNDKNVVNVGQTPVRALGATDQHSQVQLY
                     SEGPKDKVIVFVGVDKYKTTLDIPKIYGDIPSLGFLGGETHNKLIKTEQMATEYALLKS
                     GQTNMTITLPEVNEFTLGQILYLFEVATGFAGELLDINAFDQPGVEEGKNATYAMFGRP
                     GYDEKKAELDNRPAKNDKFII"
     misc_feature    complement(18208..18222)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: medium, score: 22.98"
                     /tool="antismash"
     misc_feature    complement(18209..18224)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: strong, score: 29.38"
                     /tool="antismash"
     misc_feature    18212..18227
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: medium, score: 23.84"
                     /tool="antismash"
     gene            18283..19263
                     /locus_tag="HYG85_RS11285"
                     /old_locus_tag="HYG85_11200"
     CDS             18283..19263
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024242.5"
                     /locus_tag="HYG85_RS11285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11200"
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_212693526.1"
                     /transl_table=11
                     /translation="MKDVKDDSMYLNIIAKLTNANKDYSTYTIQPQYGKGTYIIVKIIP
                     GFSLAFNNFSMNENMLNIIDRYQHFSEPILKINYCLKGKMLAFDKKGKICASGKGSTAY
                     YEGIENICKFSHFDEYESISLFGYTNQITNIFQQVFHMDKSILRGFCNQINEEDNYTVI
                     KNDLTTIGLLNDIKDNFSNGDIDSLRIRAIELFMYELKNFKTNKERKELYYSRTVVEKV
                     EKIEKYISENLDEKLTIDYLCNEFNISMDTLKRCFKQVYSTSIYAYIKKSRLEKGKELL
                     VSSEKSITEIALNCGYNNHHSFSKAFKDHYKITPRETRKVYVIGG"
     gene            19364..20755
                     /locus_tag="HYG85_RS11290"
                     /old_locus_tag="HYG85_11205"
     CDS             19364..20755
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0006855 - xenobiotic transmembrane
                     transport [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005541729.1"
                     /locus_tag="HYG85_RS11290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_11205"
                     /product="MATE family efflux transporter"
                     /protein_id="WP_334300180.1"
                     /sec_met_domain="Polysacc_synt (E-value: 2.1e-08, bitscore:
                     32.1, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKLQEKINDKDKQKQMILSENLWKVMLKISWPAVLAMVLYGLNT
                     VFDAIFVGQFVGEDALAGVSIAYPLSQVTLGFGSLIGVGAGSALSIALGSDDKNYQKKI
                     LGNVNYLSIVISVLYIIFAMLLSTPLVRVMGGTGDTLTIGRTYFQITVIGSLFWVYGLA
                     GNMIVRAEGKMKSAAVMMGVGLVVNIIANYILIVILDMGVAGAAWGTNLGMLVYTIAGL
                     VYFAKGKASFEGHPFKIRRDKHIIKDIFNMGIPSLIMTVMSLVQAVVVFNALSRYGTTY
                     DLALYGAIYRIFTLLMTPIFGLMRALQPVIGINYGAKQNMRVIKSFKIFAVGSTLMMLP
                     FWLIIMIIPQAPLGLMFPNRIFDTTSLNYFRTFMILLPILPIIFMAMTFYPAINRGKPA
                     AVIGIVRQLIFYVPVMLILPRFYGIGWVYYGSVLIDVIITLWACMLLAKDFRVLRKDMR
                     LAYET"
     misc_feature    21259..21273
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.85"
                     /tool="antismash"
ORIGIN
        1 gacgaagaat gtgacttgga ttatattcca gtaaagggaa gaaatctaga tgtaaaatat
       61 gttctttcta attcgcttgg ttttggtgga cacaatgcat cattaatcat aagtaaatat
      121 gaggaataaa cctaggtgat ggtttaaaat aatagtgtaa ggaagtgatg attcttgaaa
      181 tttgaaaata taaaagagct tataaatcta gtaagtgata aagggttaac acgtgtagat
      241 attgagaaag atggttgtaa gatatccata agaaaagaaa aagaagtttt gatgacatca
      301 aacccagaac cttatgtaca aaaaccgaat acaagccaga ctgttaacgt caataaagag
      361 actgtacaag aaaatgacag ccataaagta gaagtagaag atgaaaatac agtaacaatc
      421 aaatcaccta tagtaggaac attttatagt gctccaagtc ctgatgaaga tgattacgtt
      481 aaaataggag ataaagtatc aaaaggcaag actctatgta ttatagaagc tatgaagtta
      541 atgaatgaca tagaagctga agtttcaggt gagattgttg atgtattggt agaaaatgaa
      601 gaaatagtag aatataatca gcctctgttt aaaattagac catagataat ttattatttg
      661 tatcaaaggc atttattact ttttaaaaca ttaagaggaa aggaatagat tgttatgtta
      721 gatgctgtgg aaattcaaaa gattatccca cataggtacc catttttact agttgacaga
      781 ataacagaga tggaacctgg taaaagagcg ataggctata aaaatgtcac aatgaatgat
      841 tatttttttg ctggacattt tccagaagaa ccagtaatgc caggagtgct tattgttgaa
      901 gctcttgccc aagtgggagc agttactatg cttagtttag aagaatataa aggtaaaaca
      961 gcatattttg gcggtataaa taaaactaag ataagacgaa aagttgtacc tggagataga
     1021 ttggatttgg aaatagatat cataaaacaa aaaggtccag taggagtagg aaaagtagtg
     1081 gcatctgttg atggtgaaat agctgttact ggagaattaa cttttattgc taaatagttg
     1141 ataaaaagtt agtagaagta gaggtgaatt atgtttaata agattctgat tgctaataga
     1201 ggagaaattg ctgtaaggat tattagagcc tgtcgagaaa tgaatataca gacagtagcg
     1261 gtatattcag atattgataa agaagctctt catacacaat tggcagatga ggctatatgt
     1321 attggacctg caccagccaa agacagttat cttgatatta agaggataat tagtgcagcg
     1381 attgttacag gtgctaatgc aatacaccct ggctttggat tcttgtccga aaacagtaaa
     1441 tttgctaagg tatgtgaaga atgcaacatt acattcatag gtccaacagg tgatatgatg
     1501 gacagaatgg gtaataaatc aaaagctaga gaaacaatga ttgaaaataa tataccagtt
     1561 gtaccgggtt cagaaggtgc tgtagatggt attgatgaag ccatagaatt agcagatagt
     1621 atcggttacc cagtcattat caaagcatcc gctggtggtg gtggaagagg tatgcgtatt
     1681 gctaatagta gagaggaact agttaactcc tataaaactg caagtgcgga agcaaaaagt
     1741 gcttttggtg atgacactat gtatttggaa aaatatgtaa cgaatcctag acacattgaa
     1801 ttccaaatct tagctgataa ttatggtaat acagtacatc taggtgaaag agattgttcc
     1861 atgcagagaa gacatcagaa agttctagaa gaatcacctt ctgcagctat tgacgatgag
     1921 cttagaaaaa gaatgggtaa agcagcagtt aaagcagcta aggcaatcaa ttataaaaat
     1981 gctggtactg tagaattttt attaagtgat agtggagagt tctatttcat tgaaatgaat
     2041 acaagaattc aagtagaaca tccagtcaca gaaatggtta caggtataga tttgataaaa
     2101 gaacagataa gaatagctga cggagaaaaa ttaaattata cccaaaagga tgtcaagata
     2161 gaagggcatg caattgaatg tagagtcaat gcagagaatc ctagtaaagg atttagaccg
     2221 tctcctggag agattagttt tctacatatg cctagtggaa aagatattag agtagacagt
     2281 gccatatatt gcggttataa aatacctcca acatatgatt caatgatagc aaaattgatt
     2341 gtttatgata aagacagaaa gagtgccata aagaaattaa acagtgctat tggtgaattt
     2401 atcgttgaag gaatagacac taacatagat tttcaatatg acttaataaa taacgagagt
     2461 tttgtaaaag gaaattacaa tacttctttt atagaaaagt taatggagaa atagataact
     2521 tgatgagggc tgtcggataa tacatttttg tagatggcta catattatcc gatagcccct
     2581 tgttgagata taaataccaa atgccaattt attagatact aagaatagta aagggtaata
     2641 ttgccgctta atatgctatt tataaaagta agtttgccat ttccctaggt tcaatattac
     2701 cttttactat ttattagtat ataaaagaca atgatagcta caaccaaata aaccaattaa
     2761 aggggtatat gtatgaaaga attatttaaa aagaaaaaat acattaaatt acctataaag
     2821 acagctgtaa acggaaaaga acaatacaac gatatgagtg atccatcagt acctactggt
     2881 aaatggatta aatgtaataa ttgtggagag ataatttaca gagatgactt tgaagcaaaa
     2941 gatcagatat gtaccaaatg tcataaacat ttcaggatgg atagtgaatc aaggatatca
     3001 cagattatcg attctggttc tttcaaagaa cttaacacta atatgggaac caaaaatgtt
     3061 ctggattttc ctgagtatct agagaagata tcttcattac aaaagaaaac aggtctaaaa
     3121 gaagcagttg taacaggaga aggtaaaata aatggaataa aagttgttat agcagttatg
     3181 gacagcaggt ttatgatggg aagtatggga gaagctgtag gcgagaaagt aactagagcc
     3241 attgaacatg ctactgataa gaaattaccg attattatat ttacagcttc tggtggagca
     3301 agaatgcagg aaggaatagt atctcttatg cagatggcta agacatcttc ggcattagct
     3361 aaacatagtg aagcgggact attatatata actgtactta cagaccccac tactggtggt
     3421 gttacagcta gttttgctat gcttggagat ataattctag ctgaacctgg aaccttgata
     3481 ggatttgctg gggcaagggt aatagaacag actataaatc aaaaattacc agaaggattt
     3541 caaaaggctg aattcttatt agagcatgga tatatagaca tgatcgtaga aagaagagac
     3601 atgaaaaata cattattcaa attgctagag tttcatcaga actaacgttc attctagctg
     3661 attaatatga gaaattttga acttttggca gttatcaatt aaaattatat ttgaagaggt
     3721 gtttattata tgaacccatg ggaaaaagtt agtatagcta gaatggcaga aaggcctaca
     3781 tcagaagatt atatcaggct tatttttgat gattttatag aacttcacgg agatagatta
     3841 tatagtgatg ataaagctat aataggcgga ataggtttgc ttgaaggaat accagtaacg
     3901 gttatcggtc agcaaaaagg acgttcaaca aaagaaaata tagatagaaa tttcggtatg
     3961 ccccatccag aaggttatag aaaagctcta aggcttatga aacaagccga aaagttcaat
     4021 agaccaataa tatgttttgt agatactccg ggagcatatt gtggattagg agcagaagaa
     4081 agaggtcagg gtgaagcgat tgcaaggaat ctatttgaaa tggctagact gaaagttcct
     4141 atcatatcag ttgttatagg tgaaggcggt agtggtggag ctttagcttt agctgtatca
     4201 gacagggttt ggatgttgga gaactccata tattcaatat tgtcaccaga gggatttgct
     4261 agtattctat ggaaagacag caaaagagcc aaagaagcag ctgaagtaat gaaaataact
     4321 gctgaagacc tattggaatt aggtataatc gagaagatta tagaagaacc tgatggagga
     4381 gcacataaca gttatcacca aataagtgca gaattaaaag atagtttcat caaagagtta
     4441 gagatattaa atggattaga tgaagagcta ttgattgaaa acagatataa cagatatagg
     4501 aaacaaatca aggaataaat agtaaaataa tatggtgaaa tatagaagaa tataggaaat
     4561 aattatctag atttatgtca taaaaaagag tataatatag gcaagaaatt tctaattagg
     4621 tataatcatg atctaattag aatttcttgt cttgttttat aatagggtga atatagtaac
     4681 tttgaaggga gaataataat ggcaaagaag aagaaaaaag acacaaaaac attaaaagca
     4741 ttagctatat ttgttttggt tataggagca gtatacttag gtcttacagt aggaaaaggt
     4801 gcttttaaac cagacaccac tgctaaagat gataatgaga acaatactat tgctaaggaa
     4861 gaaaatgata ataagggaaa aactgataat gaattagatg aaactaatac tgaatccgaa
     4921 attcacccag aaaaagaagt aaaaccagaa tcagaagaaa agtcagagac agaagaacct
     4981 aaggtgaccg aagaagaaaa agacagtgaa gaagaaaatc cttctgacca agaagatatc
     5041 aaagaagaag ataatgggga gatacctcag ggaagtagta cagaagataa ctttgatatg
     5101 aatgttgatg catctacttt atctaataaa ggatatagtt ggagtttcaa aagaaataaa
     5161 gaacataaaa aggtaattgg atataacaag tttgatatta aacaatatgg tggttactat
     5221 attgtagata cagatgaaaa agttatctat ctgacctttg atgaaggata tgaaaatgga
     5281 tatacaccta ccatacttga tacactaaag gctaatgaag taaaagcaac tttttttgtt
     5341 acgaagcctt tcattgagaa taatgcggag ttagcaaaaa gaatgaaaga tgaaggtcat
     5401 atagttggaa atcatactgt acatcataaa agaatgtatg aattgacaga tgatgaaatt
     5461 aagtatgaga tagaagaaac agcaagatat tttgaagaaa tgactggata taagatggat
     5521 acattcttca gaccaccaga aggagcatat agtgaaaggt ctatatactt aactagggag
     5581 ttaggatata aaacaatttt ctggagtatg gcttatgccg attgggatac aaataaccaa
     5641 aagggtaaag aatatgctta caatcacgta attaataatg ctcatcctgg tatgatttcg
     5701 ttactacatg ctgtatcatc atctaataca gaagcgcttg atgatattat taaaacatta
     5761 aaagagcaag gttacagatt tggtaatctg tatgaaattg aataaatgaa atgattatat
     5821 aataaaaaaa taggagctgt atgcagctcc ttaatttata gacatggtaa atatattttt
     5881 aactattttt taggatataa tttttttata taattgactt agttgcaata attcatcatg
     5941 agttcctatc tgggtaatgt tccctttatc aagtagaata attctatcca tatattttaa
     6001 taattcaggt ctatgtgtaa cacaaatcac agtcttattt actaagtgag aattaataag
     6061 tttagaaata ttaatttctg acctaatatc aagggaagag gttgcttcat ctaaaataaa
     6121 tatttttgaa tccttggcaa tagctctagc tattgctatt ttttgacttt gccctcctga
     6181 cagacaagaa ccattttgcc caatcatata cgaatcagga agcgtattat aaaaatcact
     6241 taattcggac atagatatta tattatcaaa catatcatta cttatttttt tatctaatac
     6301 aatattgtct tttatagtat tttgaaatag atgggaattc tgcattactg tagcaaagtg
     6361 ctgtctatat tcatcaatag gatagtaatt aatatctgta ttatataata gaattttacc
     6421 gttattaggc gtataaaaac gtaatagtaa attaagcatt gttgatttac ctgaaccgtt
     6481 atctccaata aaagctattt tttcaccttc tcgaatttct atatcaatat tacttacaac
     6541 ggtgttgttg ttatcataag caaatgatac atctttaaaa gttaaaattg gatgtttagt
     6601 agggagacaa ttatgagtaa tgttcttgtg agtattagct tccatttcat tttctaagtc
     6661 cataaaatca aaataacgtc tagcagatgg tataatacct gttaaatagt aacctatatt
     6721 cataatagct gataatggac ttgttacttt gatactataa gaaataagag ctattatact
     6781 tccatagctt aattctccac caataagaaa gatagcacct acaatatata aaatactaat
     6841 aagagtctga atgctaatac tttctgttac catattaatt tcactaagta tatttaactt
     6901 ttgtcttatg tgaattaatt ccttttgctt agatttcaat tcaattagtt tagtatttat
     6961 taatccgtat aaccttacat cttttatgcc ggcaataaca tcaccatacc agtttgcaaa
     7021 ctcactactt ttattaataa ataatttttc atatttcata cgcaatttag aaaaatattt
     7081 agcacaaaaa aatttaatgg gtgcaatact taatactata agagaaagtt tccaactgat
     7141 gaggaataat cctacacaac taccaataat agtaaatatc tgcgtggtaa tgaataaaat
     7201 gtttttatct gctactcgag aaatattatt aatatcagta tatattctat taaaaagatc
     7261 tgtatcgttt atatctctaa tttcttcaat tttaactcta gaaagtttca aaaatgtttt
     7321 tttatttaat gtatagacta tattattttg caattttatt cttattgttt cttgaattaa
     7381 tgtcaatata ccttgtgaaa cagccagcaa aagaaggatt agtgacatct taattactgt
     7441 gcttaaattg tgttgtagta aaccatcatc tgttatattc ttaataatta atggattaat
     7501 aattgataca actgttagca taatgacaca tagcataata agaaaaaatt taaacttata
     7561 gggttttaat agtttaataa ctttcttaag tataccaaag ttattcatat gagattctcc
     7621 tttgtatatt atgataataa ttttattaat aaatcgaaaa acgattctat atttttttta
     7681 gttaagcttt caaaagttaa actatatttt tgttggttat ctgttaatac acttagtatt
     7741 atgttattat aatgtatcat gttgatttct ataattatgt cgtattttag ttgactgagt
     7801 attttattat aataatcttt attatcatta ctgctaaacc atatatttaa gtcataatta
     7861 gctaagaacg taaaataact aatataatct atcgcttttt tatggtcatt tctaatgcaa
     7921 tcaagaggaa tataatctat atcatagagt atacatgatg cctcatcatt tattaaattg
     7981 atattataac cttttttacc aaagcattct cttaaataac atgaaaacat aatcacatca
     8041 atattcttat catagaatat gcagagattt ggtatgttaa gaatagcatt atgtgattga
     8101 tgagaattat ttaggattgc attatatttt aattgattat gccataacat atgtgcatta
     8161 attttatcgt aattatgttc ggggttaata ttaattaaaa cgatattttt ttctagcgat
     8221 agtaatgaat ctaaggattc ttgatgaata tttataggag tctttgctct aataataagt
     8281 gtgtcaaaag tataatttgc tatcttattc attattgact ctatattcat agttgaatag
     8341 gatagatgta aaattatatc aaaataataa tcccatgaag ttttttcatc ataatctata
     8401 tctataatga tagctttaat tatccaatct atatatagat aatttttaat cctgttctca
     8461 ttcttacaat cattaactgc atcatttttt aatttattca aaagagtatt gatgttaata
     8521 ttattatctt cgcttatcat attgcatatc ttagcagtaa tcataggtgt agcaaaacta
     8581 ttacatttat cagaagtata ataattatgt gtgatagggt tatataactt atgctctgaa
     8641 tatgcaacta tatctattcc attttgatat ttattattta acatataata ttgattcttt
     8701 gataaatcat atatattatt ataatcgcaa ctaaccccta tagcattaga gaatgaagat
     8761 gggtatgtta taaaatcact attggatgca gcacatacaa gtattatatt aagacttgca
     8821 catctattta ctatttttcg tatggattgc atatcatcaa aatatatact tcccaaactt
     8881 aaattaacta cattaatatt atattgtata caccattcta gagctgtgta taattgagta
     8941 atattaccat tgccgttatg gtctaatatc ttaatactgc ttatactact tatgttatga
     9001 gcatattttt caataatact tgcacatata gtaccatgtg ttaatttgtc ttcaccatta
     9061 ctctgtaata atatattatt tgagttaatt tctatatttt tattaattaa ttctcctggt
     9121 aaacatttgg caataccatc atctataata gcaactcgta atttattaga cattatatgt
     9181 cgagtatata tctcgactct cactccttcc agcaattagt tatgtattat aataataaaa
     9241 tttatattaa tttataaata attatataat attaaataat tctaataata aaatttaatc
     9301 taattaatac agcataatta tattaacata ttatatcgtc ttgtcaagtt ttgacggttt
     9361 atcctttgaa acgtaaaatt attaaataaa ataaacttat tgattgacta ttttaacaaa
     9421 agggtatatt atatatctgg tgcttaataa ttttgataat aatatgagca cagtataata
     9481 aaaatcacca ataataattc atattgatga tgtaaaacta aattatagga ggtttttagt
     9541 aaatgaaaaa actaggaaaa aaagtaatga aaactggaaa cacaattaag gcgcatatgt
     9601 attgtatgtg taattcttgc ggatgctatt gtaattgttg gggcgacgaa agtgctagtc
     9661 attcttcttt ctatagtagc caatcaagtt ctagttcaag ctcttactat tcaagggtta
     9721 actaagagag aatttaattt agttcctatt taatacttag cattacatta tagcttacat
     9781 aaatgtgtaa tacaaagctg ttattaatta ttaaaatgta gagtatacat taaatatttt
     9841 tctttatttg tatacaggat ataagtggtg acagtaaata aaataggtaa ttaaataata
     9901 tgctcagtta caaagttacg tctgtacgga ggtgtctctg gtaagagaca cctcttacat
     9961 gttcagataa attttatata aacataggag gaaaaaaaag atgcagaatg atgcgttacc
    10021 ttttattcat ttatttaaaa catatgaaaa tacatatgtt tttgatataa attcaaatgc
    10081 aatatttaaa atacctaaat atgtttatga tgacttggaa cattatctta acaacaaaaa
    10141 aattacattt tcatgtgata aatctaaaga aataattgaa atgatgatga caaacggtct
    10201 attatctagt cacaaatgga aatatatgga gcatccaagt acatctatta taccacaata
    10261 ccttaaaacg tcggtatcaa cacttacttt acagattaca caagcatgta atcttatgtg
    10321 taattattgt ccttatgcgg gttcttatca taacagaaaa cattcttcca aaaagatgag
    10381 ttttgaaact ggtaaaagag ctatagattt ttatgtaaag catgcggttg atgtagagag
    10441 cttgaatata ggtttttatg gaggagagcc attaattgaa tttgatttag ttaaaagact
    10501 tgttgaatat gcaaatgaca cttataaagg taaaaagatt agatatcata tgactacaaa
    10561 tgccactctt ctaaaggatg aaattattaa gtttttagat gataataact ttaatctact
    10621 aattagctta gatggtccaa aagaaataca tgataaaaat cgtaaagatt ctcagggaag
    10681 aggttccttt gacagaattt tagagaactt aaaatatcta caacaaaatt ataaagattt
    10741 tgctagtaag ataaatttta attgtgttat tgatcctagc ttagattttg attgtttaca
    10801 taagttcttc acagattatg atactgtaaa gaattactat acatctttta actatataaa
    10861 taaacaaaat atcatagaag ataaattcaa tccaactgaa aattatacaa taaaatataa
    10921 atatgagatt tttaaattat ttttattcct tattaagcga ttagatgaac gtcatgtatc
    10981 taagatagta aaatcatatt atagcgtact attttctact atgaaggaga gacgaaccgt
    11041 ttcattttcg gaaactgaat acggacatca tagtggaccg tgtatagcag gcagtcataa
    11101 aatatttgtt gatacagagg gaaacctatt tccatgtgaa aaagtcaatg aacaatcaaa
    11161 gagttttatt ataggaaata tttgggatgg atttgatgta gaaaaagcat ctaagctaac
    11221 taatattgga aaattaacag aaaaacaatg tttatcttgt tggaacgtta atttttgtta
    11281 tctatgttgt gttttttctg acgataacgg aacactatca gctaatgcaa aattaactca
    11341 atgtaaaaat cttaagagag atacagaaga gatgatgaaa gattattgtt atctaaaaga
    11401 aatggatttt acatatgatg atgaagtatt tagaataatc taaaagaatt ggagggtgca
    11461 attatgaaag aggcaatttt atttccatat gacatatcta atatacatct attaatgcat
    11521 caagatatgt taagtgattt taggatttct ggagtagtat cccctaattc ttggggatat
    11581 gctgatgaag atgctggaag gatattaggg atagatacag gatacatggt taggtcttct
    11641 tttgaaggtc ttatagatca atgtgaatgt gtcttgtttt gtgaatctta tcttgaatta
    11701 ccatatgaat catttctaaa agagtatatt gaatatatag ctcaaaaggg taaaaaactc
    11761 atttttttag gtgaatatga acaacattgt gaagaaataa aagatatagc taaacactac
    11821 aatgcagaat atgaatttat tattaaaaaa gatgataaga aatatgaaga aatgtattgt
    11881 tacaagatga aagatattcc agtacccata ataacagtta ttggaactaa tgaaagaaca
    11941 aataaatttg atacacaatt atctgttgga aagtttttca gagaacaagg atataaagtt
    12001 ttacaaatcg ggactaaggg atatagcaat atatttgata tgatagcata tccaaaattt
    12061 atgtataacc aagaattaag tacaactaat agaatccaac agtttaacta ttacatacat
    12121 tcattatgca ttgaacaaaa accagatgtt gtaatattag gagtacctgg agctgctttc
    12181 cctatggata acaaattcca taataatttt ggctttcaca attacttagt ttccaatgct
    12241 atattatctg attatacgat ctgtagtata ccttatgaag attataaaga agattatttt
    12301 aattatctta gtacccatat taagtacaag tatggatata atatcaattg ttttattatt
    12361 gctaaccaag caattaagtg ggatgaaaca gataatagtg aaaaaataca atatttaact
    12421 cttgataaag agacaatgaa tcgtaagtgt agacattatt tagataagaa ttatccagta
    12481 tttaatatat ttgatagtaa actaaatact atgttaactc attctattct tgatgagctt
    12541 tatagtaata gtgatgaaga attaatgtag acttgagagg agattaaata tgactgataa
    12601 taatataaaa gaacagatag ttaatttgat aaatacagta aaaggtatta atctaaaaga
    12661 agaagattat gatgaacatt tattttcttc aaaaattgat ctatcacccc gtgacctcgt
    12721 atacgtcttt ttaaaaattg aagagttatt taagactaag atacctgaag agaatataat
    12781 taatgaagat tttattacaa ttaataaaat tacagaaata gtatcatcag ttagataaat
    12841 aattatatca tatagaacca tggcttaaac taaactgatt tagtctaagc catggttcta
    12901 tagctatttc ataattattt tgaaaatagt ttattgtata ggttactcac ttgacctttt
    12961 agactattta acctaacctt ggcattttca tcacctgata tatgttttag cattaattgt
    13021 ccctcttcat agcaaagttc atcatgtagt ggaaaaacct ctctaatgag gaatagagcg
    13081 tattttacaa gacggaaagg tccaactggt ctaacagtct ctccagcagg gaactccaca
    13141 cctacactat atagatcttt aatgcttttg attatatctg gttgttcatt agaaggtgca
    13201 aaaactatag tatagaacca gccgaacagg tctttgttct cacagccatg tgcatcactt
    13261 acacctacta tgggtacttt tttacccttt gctcgttctt cgtaatacct agcgatctgt
    13321 aaagtatttg atgaaaattc aaatggatga tatcccccta caacttcatt ggcatcataa
    13381 ggctgattat catacataaa gtcaattaca gaattagaga tatagtaacc cgaatcaatc
    13441 aaccaatatg gatgacagaa tatagataat cccccacctt ctctaatctt atcaaagcac
    13501 cacatgcttg aagcacattc atattttgca tgttcgtcat caagatttat tgttttttca
    13561 atttctttta cttctttata atattcatct ttattatctt gcatatattc atttacactg
    13621 aaatccccac caaaattaat aatatgaacg ttgttattct ctggatgtac ttcttcgcct
    13681 ctagctatta gtatatcaag atcaatatct ttataagtct cttggcattc tatggatgga
    13741 taatatttcc cgtggtcggt taatgccata aaatcaaatc ctatttttct acaagaagca
    13801 gttacgaatc caggagattc cttgccatcg gagtgatggc tatgcatatg taagtcacct
    13861 ttataaggta ttctatcaaa taagtctgct ctgacagagt agaaattgaa agtatatgat
    13921 ttcttggttg cagtatcagt aattttaatt atatgttctt gctctcctat aaaatattga
    13981 gtcagttgaa taacaccatc ttttgctcgg accatatact tttcttgata gttatattca
    14041 ccaatggtag aaaaatgttc taaaggataa taagcgactt caatatcggt atcagaatca
    14101 aaagtcgcat attttgctaa tggtttgatt tcaatttcag cagttgtatc agcaagtata
    14161 atcttaggcg taacctcaaa aaaacgtaat tcttctttca tggatatcct cctccaaagt
    14221 aatattttta gaaattatag cacattatta ttgggaaaac aagaatatta ttgataattt
    14281 atgaataaat gtgtaattgt ggtgtaataa atgtgtaaat atagcttgtc tatataaaaa
    14341 acccttataa aaaagttgat attatataaa aatgtggtat aattaataaa aataattggt
    14401 tttgtaagta tatatgtgta tatgtgtgga attaattaaa agttaagaag gagaagtgct
    14461 aattaatatg actaaattaa gtaaatcaca aataagaata tttatattat gttgggttgc
    14521 gtatgctagt atatactttg gaagggttaa cctatcagta gccattcctc agattcaaga
    14581 tacttttggt tggtcaaaag ggtccatggg gttaatcggt agtctatttt attgggtgta
    14641 cggttttgga caacttatca atggacaaat aggagatagg atatcaacta gaagaatagt
    14701 cttttttgga ttaatcacta cagctatatg caatatatgt tttggattca gtactacata
    14761 tatatttatg atggttttat ggattataaa tgcatatgcc cagtcaactc tatggggacc
    14821 catagtaaaa tctataacca attggtatga acctaaaaaa agaagttctg tttcaatagg
    14881 tatctcaact tcaatggtag gaggttatat actagcctgg ggaggttcag gacttattat
    14941 tgcaaaatcc cattggaatc ttgttttttg ggtaccaggt attatcatac ttatatattc
    15001 aataatatgg ttctcgtttt ttagagatac accaaaagaa gccagtaagt atatatctga
    15061 tgagcctact gaaggggcaa ctgtaaaaga caataaatac agtctattac aagtcataat
    15121 agaatccaaa ttaatataca tagtattagc ttgttttgtg caaggaataa taaaagattc
    15181 tattgcatta tgggcaccaa ctctattcat ggaaactcag aatctggaca ttactgaaac
    15241 cactcaattc attatattca tacctgtgat gaatctattg ggtatgatgt ttgcgagttt
    15301 cctgaataaa aaattgaagc acaaagaaaa aaggacaata tatattttgt ttttgataag
    15361 tatattcatg ataatagggt ttgtgaaatt aggttcctac aatataataa tcgctcttat
    15421 atttttaggt ttgacatctg cggttatgta tggagccaat actttattgc ttggtgtaat
    15481 tccattacat tttgcaaaat ataataaaac atcttctata gctggatttc tggatttctg
    15541 ttcctacctt gcagcagggt ttgctgcatt tattacaggt gctttagtgg atagattcag
    15601 ttggaatggt gttatgattt tttggatagt ttgcttagtt gttggaatat ttgctttgct
    15661 tatgagcctt aagtgtgata aaatagcagt gaaaatggaa aaagtaacag ataatacata
    15721 tttaattgat tagaggagat gggagttttg ttagcagaag aaagatataa aattatacta
    15781 gacctattag aaaaaaataa ttccgtaaaa tcttcttatt taatagaact ttttggtgtt
    15841 tcagttgaaa cagtaagaag agatctagaa catttagaaa aagaaggttt tctacatcgt
    15901 gtacatggtg gtgcaatgct ggaccagata aacccaaaat caatagactt taaaataagg
    15961 gaaaaaagcc ataaccaaga aaaagtaaat atagcccaaa atgcaatggg atttatatct
    16021 gaagaatctg taatagctct tgataatgga actacaacgt tagaaatagc aaaacttcta
    16081 aaaaacaaat acaagaaatt gactatactg accaattcca tattggtagt tgaagaatta
    16141 gtaaatgaac cggattatac aataatactg ctaggtggta ttgttaatac taaggacaag
    16201 tctctgaagg gtgagcttgt agagaattat atcaatctat ttcatataga tatatgtttt
    16261 ataagtgtaa gcggaatatc tttaaaagaa ggagcaacag aatttgagat tgataccatt
    16321 ccaatacaga aaaggcttat tgagcgttct ggcaagaaga tactactagc tgatagcagt
    16381 aaatttggag ttgtatcctt attgaaagta tgtgatctca atgatgtaga tcatatcata
    16441 actgactcca atctaaaaga agcaatttat gaaagatata aagcaaaagg aatagatgta
    16501 attaaatagc tctttactat ttacaaagct atccatatta tatataattt atgctgtcgt
    16561 acaataacaa taatgatagt agacgttact tcatttttaa attaataaaa aaacaaggaa
    16621 agtttcatac atttttgcaa ataataatta tgaaatggac tttactataa aaaatattag
    16681 gaggtacata aatgtccaag agatttgaac aaaaagactg gcaagaaagc atgagattaa
    16741 aattagattt taataatatg atgacatctt atgttggaga gaacggtatc agcgaagaag
    16801 aaatcgctga tttacaagca caaattgaga aagctgaaaa agcaatggta gaaaaaagag
    16861 ctaatggtgg tatggattgg agagatttac catataacca agctgatata gttaaagata
    16921 ttaatgcata tgttgaaagc gttaaagatg actttgatac ttttgtagta cttggtatcg
    16981 gtggttcagc attaggacca atcgctgtac aacaagctat caatcatcca tattataatg
    17041 aactgtcaaa agaaaaaaga ggcggttatc ctaagttgta tgtaatggat aacatcgacc
    17101 ctgaaaagtt agtatcacta tttgatatta tagatcttga taaaacttta ttcaatgtta
    17161 taacaaaatc aggaagcact tctgaaacaa tgtcccaatt catgattatc aaagagatgt
    17221 tagaagagaa attaggcaaa gaagagtcta aaaaacatgt tgtttgtaca acagatgcca
    17281 aaaacggtaa tcttagaccg atagctgata aagaaggcta taagagtttc attatcccag
    17341 caggagttgg tggaagattt tcagaactta caccagttgg tttattacca gcagctatgt
    17401 gtggtataga tattgaagaa atattggctg gagcagctta tatggacgaa ttatgtaaaa
    17461 ctgataatac attcaagaac ccagcttcaa tgtatgcaat tcttaactac ctagctatga
    17521 gaagaggtaa gaatatatca gttataatgc cttatgctga tacattaaaa tacattggtg
    17581 actggtatgc acagttatgg gcagaatcat taggtaagaa atttgataat gataaaaatg
    17641 ttgttaatgt aggacaaact ccagtaagag cattaggagc tacagaccag cattcacaag
    17701 ttcaattata ctcagaagga ccaaaagata aagttatagt atttgttggt gttgataaat
    17761 acaaaacaac tttagatatt ccaaagatct atggtgatat tcctagcctt ggattcttag
    17821 gtggagaaac tcacaataaa ttaattaaaa ctgagcaaat ggcaactgaa tacgccttgt
    17881 tgaaatcagg tcaaacaaat atgactatta ctttaccaga agtaaatgaa ttcacacttg
    17941 gtcaaatctt atacttgttt gaagtagcta ctggatttgc aggtgaacta cttgacatta
    18001 atgcttttga ccaaccaggt gtagaagaag gtaaaaatgc aacatatgct atgtttggaa
    18061 gaccaggcta tgatgaaaag aaagctgaac ttgataatag accagctaaa aatgataaat
    18121 tcatcatcta gtactagata aaaaatatat ggcttactta taatagaatc cgatattata
    18181 agtaagcctt tttatataaa tatgatgtga taatgattat cattattgaa attaaatgga
    18241 atctttggta tacttgaata aataaactta ggaggactat atatgaagga tgttaaagac
    18301 gattctatgt atcttaatat aatagctaaa ctgacaaatg ctaataaaga ttattctaca
    18361 tatacaattc aacctcaata tggaaaagga acatatataa ttgtaaaaat tatacctggg
    18421 tttagtttgg cattcaataa ttttagtatg aatgaaaata tgttaaacat aatagataga
    18481 tatcaacatt tttcagagcc tattcttaag ataaattatt gtttaaaagg gaaaatgctt
    18541 gcattcgata agaaaggcaa aatctgtgca tcaggaaaag gcagtactgc atattatgaa
    18601 ggcattgaga atatatgcaa gtttagtcat tttgatgaat atgagagtat atcactattt
    18661 ggttatacca atcaaataac taatattttt caacaggtgt ttcatatgga taaaagtatt
    18721 ttaagaggtt tttgtaatca gataaatgaa gaagataact atacagtaat taaaaatgat
    18781 ttaacaacta taggtttact taatgatatc aaagataatt tcagcaacgg tgatatagat
    18841 agtctaagaa ttagagctat agaattattc atgtatgaat tgaaaaactt taagaccaac
    18901 aaagaacgaa aagaattgta ctatagtaga acagtagttg agaaagtaga aaaaatagaa
    18961 aaatatataa gtgagaatct ggatgaaaag cttacaattg attatttgtg taatgagttc
    19021 aatatctcga tggatacctt gaagcgttgt ttcaagcaag tatattcaac tagtatatat
    19081 gcttatatta agaaatcaag acttgaaaaa ggaaaagaat tattggttag tagtgaaaag
    19141 agtataactg aaatagcatt gaattgtggt tataacaatc atcatagttt tagtaaagca
    19201 ttcaaagacc attataaaat aactccaaga gagactcgta aagtttatgt tataggtggg
    19261 tgaacaactt tttatctgaa tggaaccttt ttgcacgaaa cgcgatagaa gctgttatct
    19321 taatgtgtta aactggtaaa aaattgacac aaaaagatat ggagtgatta aattgcagga
    19381 aaaaataaat gataaagata agcaaaaaca gatgatactt tctgaaaatc tttggaaggt
    19441 tatgctgaaa atatcttggc ctgctgtatt agcaatggta ttatacggac tcaatacagt
    19501 atttgatgcc atttttgtag gacagtttgt aggagaagat gctttagctg gagtttcaat
    19561 agcctatcct ttatcacaag taactctagg atttggttct ttgataggtg ttggagctgg
    19621 ttcggcactg agtattgcac taggctcaga cgacaaaaat tatcagaaaa aaatattggg
    19681 taacgtaaac tatctgtcaa tagtaataag tgttttatac ataatatttg ctatgttatt
    19741 atctactcct ctagtacgag ttatgggtgg tacaggtgat acattaacta taggtagaac
    19801 ctatttccaa ataactgtaa tcggttcttt gttctgggta tatggtttag ctggtaacat
    19861 gatagtacgt gctgaaggaa agatgaaatc tgctgctgtt atgatgggag ttggacttgt
    19921 agtcaatata atagctaatt acattttgat tgttatttta gatatgggag ttgcaggagc
    19981 tgcatgggga accaatctag gtatgttggt atataccatt gcaggacttg tctattttgc
    20041 aaaaggcaag gcatcctttg aaggtcatcc attcaagatt agaagggaca aacatataat
    20101 aaaagacatt ttcaatatgg gtataccgtc attaataatg actgttatga gtttagttca
    20161 agcagtagta gtttttaacg cattatcaag atatggaaca acatatgacc ttgcactcta
    20221 tggtgctatc tataggatat tcactttact catgactcct atatttggac taatgagagc
    20281 cttgcaaccg gttattggta ttaactacgg tgcaaagcag aatatgcgtg taatcaagag
    20341 cttcaaaata tttgctgtag gaagtacatt gatgatgttg ccgttctggc tgataatcat
    20401 gattattcca caagcaccat taggcttaat gttccctaat aggatctttg atacaaccag
    20461 tttgaattat tttagaacgt ttatgattct attaccgatt ttaccaatca tatttatggc
    20521 tatgaccttc tacccagcaa taaatagagg taagccagca gcagttatag gtattgttag
    20581 acaattgata ttctatgtgc cagtaatgct tatattacca agattctacg gtataggatg
    20641 ggtttattat ggatcagtgt taattgatgt aatcataaca ttatgggcat gtatgttact
    20701 tgctaaagac tttagagttc ttaggaaaga catgagatta gcatatgaaa cttaacgata
    20761 aaaaaggagc gaaaagctcc tttgagaatg tcctaaaaag tgtgtaaaat atctccaacc
    20821 tggctaaaat ctaaataaaa atgccaggaa ggagatttta ctatggcaaa taatcttatt
    20881 actaaagaac aagcacaatc aataattgaa aacaatgata tcaaaactcc acaagatatt
    20941 atgggtgctc taaaaaatat gtttagggat gttattcaag aaatgcttga aaacgagatg
    21001 gatgaaactc taggctacga acgttacgat catgaccaac ctaaatccaa ctatcgaaat
    21061 ggttattctc aaaagaaagt tcgttcttct ctaggtgaaa tagatattga tgtgcctaga
    21121 gaccgaaatg ctgattttga acctaagatt gttcctaaac ggaaaaaaga tatttcagat
    21181 attgagaaac aaatcataag tctctatgct cgtggtatgt ccacaagaga tattcatgaa
    21241 caaatgaatg aactctatgg aataaatgtt tcggcagata tggtaagtag aataacggat
    21301 aagctaatac caacaattaa agaatggcaa ggaagaccct tagaacctat ataccctttt
    21361 gtttttatgg atgcaattca ctttaaagta agaaccgaag gacgcgttat caatcgagca
    21421 gcttatgtga tcattggtgt taa
//
