LOCUS       NZ_CP058561            26324 bp    DNA     circular CON 15-DEC-2024
DEFINITION  Vallitalea guaymasensis strain Ra1766G1 chromosome, complete genome.
ACCESSION   NZ_CP058561
VERSION     NZ_CP058561.1
KEYWORDS    RefSeq.
SOURCE      Vallitalea guaymasensis
  ORGANISM  Vallitalea guaymasensis
            Bacteria; Bacillati; Bacillota; Clostridia; Lachnospirales;
            Vallitaleaceae; Vallitalea.
REFERENCE   1  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Vallitalea guaymasensis genome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5626074)
  AUTHORS   Postec,A.
  TITLE     Direct Submission
  JOURNAL   Submitted (01-JUL-2020) Microbiologie Environnementale et
            Biotechnologie (MEB), Mediterranean Institute of Oceanography (MIO),
            UMR 7294, 163 avenue de Luminy, Marseille 13288, France
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: Unicycler v. JUNE-2020
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141425.1-RS_2024_12_13
            Annotation Date                   :: 12/13/2024 15:20:22
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.9
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,859
            CDSs (total)                      :: 4,781
            Genes (coding)                    :: 4,757
            CDSs (with protein)               :: 4,757
            Genes (RNA)                       :: 78
            rRNAs                             :: 6, 6, 5 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 5 (5S, 16S, 23S)
            tRNAs                             :: 57
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 24
            CDSs (without protein)            :: 24
            Pseudo Genes (ambiguous residues) :: 0 of 24
            Pseudo Genes (frameshifted)       :: 7 of 24
            Pseudo Genes (incomplete)         :: 16 of 24
            Pseudo Genes (internal stop)      :: 1 of 24
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 17:55:59
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1581902
            Orig. end                         :: 1608226
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP058561.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..26324
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="3"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..26324
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26324
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16324](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16324)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     misc_feature    165..180
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 23.76"
                     /tool="antismash"
     misc_feature    303..318
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 22.57"
                     /tool="antismash"
     misc_feature    1661..1671
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
     misc_feature    complement(2007..2022)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.8"
                     /tool="antismash"
     misc_feature    2008..2021
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: medium, score: 22.2"
                     /tool="antismash"
     gene            complement(2150..2812)
                     /locus_tag="HYG85_RS07205"
                     /old_locus_tag="HYG85_07115"
     CDS             complement(2150..2812)
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0016788 - hydrolase activity, acting on
                     ester bonds [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012863.5"
                     /locus_tag="HYG85_RS07205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07115"
                     /product="SGNH/GDSL hydrolase family protein"
                     /protein_id="WP_212692905.1"
                     /transl_table=11
                     /translation="MINNVKDDSLILFQGDSVTDCGRTSNEYLELGFGYANMVASWLTA
                     LHPEKQLRFLNRGISGNRVSDLKKRWQEDCIDLRPEVVSILIGINDCWRRYDSNDPTSV
                     DSFEITYRQILTNIKQKLEAKIIIMEPFLLPVIEESEGWSAGQDKWREDLDPKIHVVRS
                     LAREFNAEFIPLDGIFARAATIQPMEKWTLDGVHPTQAGHALIARQWLKAFGVVEKM"
     misc_feature    complement(3061..3081)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 28.31"
                     /tool="antismash"
     gene            3064..4710
                     /gene="hcp"
                     /gene_synonym="priS"
                     /locus_tag="HYG85_RS07210"
                     /old_locus_tag="HYG85_07120"
     CDS             3064..4710
                     /EC_number="1.7.99.1"
                     /GO_function="GO:0016661 - oxidoreductase activity, acting
                     on other nitrogenous compounds as donors [Evidence IEA]"
                     /GO_function="GO:0051536 - iron-sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hcp"
                     /gene_synonym="priS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019161395.1"
                     /locus_tag="HYG85_RS07210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07120"
                     /product="hydroxylamine reductase"
                     /protein_id="WP_212692906.1"
                     /transl_table=11
                     /translation="MDNAMFCYQCEQTAGGKGCTKMGICTKDPNVAKMQDVLIFLLKGL
                     GYYATKLIEDGQVIPRELGEFCTECVFATLTNVNFAPERFVEYIKKTNYYKKDLMNKAS
                     TSDAPEGADYIAPETKEEILSIPNMKNLGVMDDEDLDMDIRSLRELLIYGIKGMGAYFH
                     HAYVLGKYDAEIANFMFKALSSTLDRDLTVEDYFNLNMELGKTNFKCMELLDAANTGAF
                     GDPEPTEMLITKKKGPFIVVSGHDLNDLGDLLEQTEGKGINIYTHGEMLPCNAYPGLKK
                     YKHLIGNFGGAWQDQQKEFDNLPGAILMTSNCLMKPRKSYKDRLFTSSIVGWPDVTHIP
                     TVDGHKDFTPVIEKALKLEGFTADEPEKRIPMGFARNAVLSNADTIVNAVKEGKIRHFF
                     LIGGCDGARPGRNYYTEFAEKTPKDTIILTLACGKYRFNKLDLGSIGPFPRILDVGQCN
                     DAYSAIKIALALSEAFECDVNDLPLSYIITWYEQKAVVVLLTMLYLGLKDIYLGPTLPA
                     FITPNILQVLVDKFNLQSISTPDHDLQTILG"
     gene            complement(4783..5076)
                     /locus_tag="HYG85_RS07215"
                     /old_locus_tag="HYG85_07125"
     CDS             complement(4783..5076)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS07215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_07125"
                     /product="hypothetical protein"
                     /protein_id="WP_212692907.1"
                     /transl_table=11
                     /translation="MFNEEIEATRFGRGRRPYRYRYPRYYPYSYRRYPYYYRRNPYYVR
                     YPYYRRPYYYGRPYYYGRPYYYGRPYYRPYRGRGRGRLYGMEEDNYSDIIYV"
     gene            5308..7095
                     /locus_tag="HYG85_RS07220"
                     /old_locus_tag="HYG85_07130"
     CDS             5308..7095
                     /EC_number="3.4.11.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012766.5"
                     /locus_tag="HYG85_RS07220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07130"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_244971295.1"
                     /transl_table=11
                     /translation="MAEITVNERIELLRQEMKKEGLSAYIIPSADPHQSEYVAEYYKSR
                     AYISGFTGSVGTVIITMSESCLWTDGRYFIQAEKQLSDSEVVLYKMLEPGVPTYQEWLK
                     DNIKAGEKIGFDQRLFSVNDMKMLKNVINNDKIELVGNIDLISNIWKNRPALPTDKVFY
                     HDIKYTGSTAAEKIDSIRNEMKKKDSEIYLISSLNDIAWLFNIRGNDIIYTPIPYAYGI
                     ITLTEAILYIQLDKVPEDVRAILEEQNIVIKAYEDIFDDIKIYTKDLTVTYDPTKLNYG
                     LKSMIDSSSRIVETLEPTAIVKAKLNDTEIMNLKECEIKDGVALVKFLYWLEKAVPSGD
                     ITEITAAEKLASFRKENPLYIEDSFATIPAYQENAAMMHYKPDVATTKTLKPKGFFLLD
                     SGGQYHDGTTDITRTIVLGDITEEERHDYTLVVKAHIALARLVFLHGSTGSNLDVIARQ
                     PIWQEYMDYKCGTGHSVGFLLGVHEGPARIRKGSSDVVIEEGMYLTNEPGIYKENKHGI
                     RIENSILVKEVMNNSDGRFMAFDTISYCPIDLKGIDVTILTCDEKDWLNNYHQEVYNKL
                     SPHLNEDECLWLQSQTKSI"
     misc_feature    5323..5334
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.59"
                     /tool="antismash"
     gene            complement(7146..8276)
                     /locus_tag="HYG85_RS07225"
                     /old_locus_tag="HYG85_07135"
     CDS             complement(7146..8276)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019522.5"
                     /locus_tag="HYG85_RS07225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07135"
                     /product="YibE/F family protein"
                     /protein_id="WP_212692908.1"
                     /transl_table=11
                     /translation="MNKKIRVSFIYGILCIIIFLLFIQSNKSSDKYNKNVREIKAKVIE
                     VDDSNVVKAGVSAIGFQELKVIAGNSNYKGETIDVENQLVGKLDYDNYYKIGDIIIIAV
                     KTENDKIIDAKAVDLYRQNYLGFIFLVFVILLIIYARSIGVKALLSFICTMFILWKFLI
                     PNLLQGKNPLIIAFITLFALSAIILFTVAGFNKKGISAFLGTLSGLLITLVLTMVVGDK
                     LGLMGMTSPYAETIVFSGYFDLNMKYIFYVAIIIGSSGAAMDIAMDVSSACQEIKNKKK
                     NITQRELIKSGFNVGRDVIGTMTTTLLLAYSGGYLTLLMLFQIRDSSFTRIINMKIISA
                     EIMRTLIGSIGLVIVAPITAIIAGILMGTKVIKKLD"
     gene            complement(8392..9867)
                     /locus_tag="HYG85_RS07230"
                     /old_locus_tag="HYG85_07140"
     CDS             complement(8392..9867)
                     /EC_number="3.1.3.1"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012470.5"
                     /locus_tag="HYG85_RS07230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07140"
                     /product="alkaline phosphatase"
                     /protein_id="WP_212692909.1"
                     /transl_table=11
                     /translation="MKKKIIGIALMTMMILSLSLQSNDILKAVNSTVLANTSVKTPKYI
                     FYFIGDGMGTSQRQISEYYLQEISGDKDKKLVMNTFPHSAINTTHSLNTLITDSAAAGT
                     ALATGHKTNNGVISKDVEGNNLKTLIESAEEKGMATGLASTTRITHATPAVFASHNESR
                     GNENDIAVDFLDSGVDYIVGGGVRHFLPMDFTDNQTDAFGGKIYSKRKDDKNVLADFRN
                     EGYTVRYGVKGAEEFRNDVFKKGDKYLNLFTASHLPYTIDDENNDKYHVPTLAEITSKG
                     IDLLSKDEDGFFFMIEGGRIDHACHPNDPSGTIMDTLAFDKAVEEAYEFYKKHPQDTLI
                     IVVGDHETGGLGMGVNTDYFLNLQELEKAIMSIEEFQGSYTGDRKEYYNLIGEKFGLTE
                     LSDEEKAIIDKGMDMVDKEIIDPGNAYKYDEAAMAVTHVLSERAGIYWTSYAHTATQIP
                     MSAIGVGAENYNGFMDNTTIAEITAKIAGLELN"
     misc_feature    9936..9953
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.94"
                     /tool="antismash"
     gene            complement(10001..11338)
                     /locus_tag="HYG85_RS07235"
                     /old_locus_tag="HYG85_07145"
     CDS             complement(10001..11338)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.5"
                     /locus_tag="HYG85_RS07235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07145"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_212692910.1"
                     /sec_met_domain="LANC_like (E-value: 3.5e-61, bitscore:
                     205.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKWSQVTDEEIRNKIQRIVDDGAHRLVNPEQIQKDMLELINIRKE
                     SGKDYIPWSPIDLARGYSGFCVMFGALDRAYPQGGWDSIGHPYLQKIQRVIMKEGIREF
                     SLWTGIGGVIIAARALSRDGTRYETFIKELNSFFIKSFPSMMQYMESRLKQGISLKEFD
                     VIQGLSGIGRYVLCFIEEKEMRLAMEQILEYLVKLCADKEHKGLVVPGWYVSSDRCTGY
                     DSKEYPNGHFNCGMSHGIPGVLALMSIALMKGVEVSGQREAIHKIANWIIKWKENDEYG
                     PLWPARISWEENKKGKSRNVVPREAWCYGGPGIARALWLSGIAVNNEEWKSVALETFRG
                     TAMRPKSKWNIESDTFCHGRAGLLQMVQRMYSESGDKIIGELRDKLLEQVLNLWNPEEL
                     YGYQEKESSDKQDIAGLLDGAAGVFTVLIGLIQEQDTDWDLIFLIR"
     gene            complement(11313..13175)
                     /locus_tag="HYG85_RS07240"
                     /old_locus_tag="HYG85_07150"
     CDS             complement(11313..13175)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.5"
                     /locus_tag="HYG85_RS07240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07150"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_212692911.1"
                     /transl_table=11
                     /translation="MAVDREDSSVMSIANILKSFRYWPRIMGLLWATDAKSLIAIMILN
                     LFHGISPIIVLILTKDLINSITYSWTEGFNVILKAFAILVAFTLLSQLLNLIQSYIESL
                     FKVLLMNRINKLIMEKSVSLSLKDFENSEVQDALKLAQNEAGHRPYQIMQQMMSLISGI
                     VTLISAAGMLIIFRWWMAFILLIIPFTSFYSFLRIGQQEFLVQYNRIPKMRKAWYYSYL
                     MTNDKNFKEVKLYQLGKYLQRCYNGLFKSFYKEDKKIAKKRLSTGIIFQVINVIANVLM
                     MVVVLRSAFLREIEIGTVVALTQTITMTQSNSQALISGILSLCQHNLFLKQLFIFLDLK
                     VSKNDKGKRTDIMEIETVEFKNVSFMYPDTNRYALNNVSFKLKRGETMAIVGRNGSGKT
                     TLMKILTGLYDDFKGDILINGISIRSFNQEALRNHMAVVCQDFVQYELNMRHNIGFGNV
                     NRLERDDELLESARRAGIDDLVDQLPHGLDTQIGRLFDQGSQLSGGQWQRVAIARAFMR
                     KADLYILDEPSSMLDPESELQVFEKFRELIHQHIGIFISHRYTSIKYADHIIMMDQGEV
                     VEQGSHIELMKKDSMYAYLYKMQLSAYSDNDKEEVQYEMVSGDR"
     gene            complement(13181..16324)
                     /locus_tag="HYG85_RS07245"
                     /old_locus_tag="HYG85_07155"
     CDS             complement(13181..16324)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.5"
                     /locus_tag="HYG85_RS07245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07155"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_212692912.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 3.6e-188,
                     bitscore: 624.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 5.4e-17,
                     bitscore: 60.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 2.5e-30, bitscore:
                     104.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQSIFKCLDFFILRTPILSTNVFENKLTSFNAPILDELWEFTQ
                     DPLIREAIAVSSISLLDALTNLSPDSPSRKREQVARAFLRYLIRMSTRPTPFGLFSGVA
                     YGEYGDYYKVALRSTEYHEKRTRPDMDWLFKIIAQMENDPNLIKQLIVMANTMAYKVGN
                     RTYLPYLTNLGQAKGKGNEMERTSVRTTSAVKQALNLSEKPMTYKELVNKLNVEYPDTP
                     REQINQFVYQLFKQELLISNLRPPLIEANPLNYLLQRIEDIKGIDKLKAQLQEISFMID
                     MYDRTLLGEGEELYRNIIKKMKKIAESKNYLQVDLKIQKDEVVLPISIKEEVEKAAEVL
                     WKISDNEYGLSHFLEYRNDFIKKYGSSREVPLLELLDEEIGLGSPATYEYPPSKRNPKE
                     NRTEFQQRKKYLLSQWLTMTLLKGEQEIVLDDEKIEELAGEEVDSRYAPRSFELFFSLA
                     ADSKESVEAGDYTLISGATALSYGAGRSIGRFTDIMGSEFQDELKKFGKSEQEMCSDGI
                     LAELVYLPIDGRAANVVLTYDNRNYEIVMGTTSSKKPENIIPLSDLVVGIDKRGFYLRS
                     LKLGKEVITVVNHMFNGSNSPNVYRFLRELSMERQRNIENLHWGEFNSLPFLPRIKYGR
                     CILSPARWIINKETFPIEDNMNKEEWIEKFDTYKKELRLPRYVYLTQTDNRLLLDLNES
                     EHIDEIRREFAKLGFGQGIILTELGHELGALPKSQEGSYYTEFVFPIIRNPAIKNRESI
                     PKRQYKPIDLAERFKLPGSEWMYVKWYGAWNRIEEFLGGRLREFCYKAEQNGWIGSSFY
                     MRYADPDGHIRLRFFGEPKKLQSEFLPQLNIFANNCLKEGMLSRMVIDTYDPEIERYGG
                     RELINIAEQWFCIDSKIVMDWIKLNEQGILPIEKDLLAVISIIDIMEQFGLTFEEQLAF
                     LDKIVNYKNYLDLFRSKRSLYMKLGDTRDGFAELRRHEAGQFLLPALQARSNTLNYYGE
                     QLSKKELSGDYYVKSIDAMHSIIHLHINRLYGIDRGDETRVLTLVRHTLHNLVYIRRR"
     aSDomain        complement(15587..15871)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_HYG85_RS07245_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="3.20E-19"
                     /identifier="RREFam001.1"
                     /label="HYG85_RS07245"
                     /locus_tag="HYG85_RS07245"
                     /protein_end="246"
                     /protein_start="151"
                     /score="60.4"
                     /tool="antismash"
                     /translation="VMANTMAYKVGNRTYLPYLTNLGQAKGKGNEMERTSVRTTSAVKQ
                     ALNLSEKPMTYKELVNKLNVEYPDTPREQINQFVYQLFKQELLISNLRPP"
     misc_feature    complement(16353..16362)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     misc_feature    16372..16381
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.57"
                     /tool="antismash"
     gene            complement(16408..16599)
                     /locus_tag="HYG85_RS07250"
                     /old_locus_tag="HYG85_07160"
     CDS             complement(16408..16599)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF033457.1"
                     /locus_tag="HYG85_RS07250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07160"
                     /product="elgicin/penisin family lantibiotic"
                     /protein_id="WP_193774429.1"
                     /transl_table=11
                     /translation="MAKNPFDLEVKVDKINGAELDGLYTSTCYTSSCYTSTCYTSTCYS
                     SDCYTGQNMCGYTHTSSC"
     CDS_motif       complement(16537..16599)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MAKNPFDLEVKVDKINGAELD"
                     /locus_tag="HYG85_RS07250_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16408..16536)
                     /prepeptide="core"
                     /locus_tag="HYG85_RS07250_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="1.50"
                     /molecular_weight="4244.5"
                     /monoisotopic_mass="4241.7"
                     /core_sequence="GLYTSTCYTSSCYTSTCYTSTCYSSDCYTGQNMCGYTHTSSC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MAKNPFDLEVKVDKINGAELD"
                     /leader_location="[16536:16599](-)"
                     /alternative_weights="4262.6"
                     /alternative_weights="4280.6"
                     /alternative_weights="4298.6"
                     /alternative_weights="4316.6"
                     /alternative_weights="4334.6"
                     /alternative_weights="4352.7"
                     /alternative_weights="4370.7"
                     /alternative_weights="4388.7"
                     /alternative_weights="4406.7"
                     /alternative_weights="4424.7"
                     /alternative_weights="4442.8"
                     /alternative_weights="4460.8"
     gene            complement(16951..17703)
                     /locus_tag="HYG85_RS07255"
                     /old_locus_tag="HYG85_07165"
     CDS             complement(16951..17703)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013356.5"
                     /locus_tag="HYG85_RS07255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07165"
                     /product="6-phosphogluconolactonase"
                     /protein_id="WP_212692913.1"
                     /transl_table=11
                     /translation="MKFQKDKLVVEVYGNRELMGKAAGKDIADSIKNLLKKQEEVNIIF
                     AAAPSQTDVFKYLKEADDVDWRRVNAMHMDEYHTLNNNHSAKFANFLERELFSNINLKN
                     IYYLKERDETKEEIIAKYQKILKNNKIDIVICGAGENGHIAFNDPHVANFQDKELIKEI
                     TLDEACRIQQVNDGCFSSLDEVPKQAITLTIPALMSANQIFCIVPGKLKHQAINKLLKG
                     EITEEVPVSIIRTHNQAKLYLDQDSYIG"
     gene            complement(17718..18902)
                     /gene="nagA"
                     /locus_tag="HYG85_RS07260"
                     /old_locus_tag="HYG85_07170"
     CDS             complement(17718..18902)
                     /EC_number="3.5.1.25"
                     /GO_function="GO:0008448 - N-acetylglucosamine-6-phosphate
                     deacetylase activity [Evidence IEA]"
                     /GO_process="GO:0006044 - N-acetylglucosamine metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="nagA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Amidohydro_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006778611.1"
                     /locus_tag="HYG85_RS07260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07170"
                     /product="N-acetylglucosamine-6-phosphate deacetylase"
                     /protein_id="WP_212692914.1"
                     /sec_met_domain="Amidohydro_1 (E-value: 3.3e-32, bitscore:
                     110.2, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTILIKNGNIIEKDGIKKGSVLIKDKKIEQIFYTEDFNCNYDMV
                     IDAKEQYISPGFIDIHTHGGGGHDFMDNTEEAIYKAVYAHMVHGTTSIVPTTLTNTKEN
                     LNTFMNIFNNIDLNKKGYPNILGLHLEGPYFSYGQRGAQDPRYLRNPEPEEYNKILSLT
                     DRIIRWSLAPELEGALEFAQVLKEKKINCSIAHTEATCEEVKKAYENGYICLVHFYSGM
                     NSVIRKNAYRVAGAVEAGYLLDDIYVEVIADGSHLPKELLELIYKIKRKDRICLVTDSM
                     RAAGMPDGLYTLGGKDSGYEVVVEDNVAKLTDRSAFAGSVATSDILLKTMYYNTSASLD
                     EVVNMLTINPATLLNIEDQKGSIEIGKDADIIIFDDKQEISLVMVMGDININKI"
     gene            complement(18903..19655)
                     /locus_tag="HYG85_RS07265"
                     /old_locus_tag="HYG85_07175"
     CDS             complement(18903..19655)
                     /GO_function="GO:0097367 - carbohydrate derivative binding
                     [Evidence IEA]"
                     /GO_process="GO:1901135 - carbohydrate derivative metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SIS_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF002805.0"
                     /locus_tag="HYG85_RS07265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07175"
                     /product="sugar isomerase domain-containing protein"
                     /protein_id="WP_212692915.1"
                     /sec_met_domain="SIS_2 (E-value: 3.2e-36, bitscore: 122.5,
                     seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVMNQYHEHVFGIINRIHNEEKDRILKVAQVIAEHIKKDKLVYV
                     WGPGGHSNLATMEIFFRAGGLMHINAILDGGTMLNHGALRSMQIERLPGYGKVVINDYG
                     IGEGDLVIIVNAYGINAATIEAALESKENGATTIGICSFEHAESTPQDHIARHPSKKNL
                     HEIVDYAIDSKIQVGDAVIKLDNFEQKIGALSTFANAYVMNCIVIEAIDMLVKQGIKPP
                     VWMSGNADGGDEWNNQFLGKFKDKIKVL"
     gene            complement(19659..20915)
                     /locus_tag="HYG85_RS07270"
                     /old_locus_tag="HYG85_07180"
     CDS             complement(19659..20915)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016612.5"
                     /locus_tag="HYG85_RS07270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07180"
                     /product="neutral/alkaline non-lysosomal ceramidase
                     N-terminal domain-containing protein"
                     /protein_id="WP_212692916.1"
                     /transl_table=11
                     /translation="MQLGVSKISITPSKKIRLAGYANRLEPFIDVIHDIYTVVYYFRTS
                     DEDKVIIYGDLLWWGSDFIDTMNKRISQRFNLSYENIVFTASHNHSGPGTSENFTELLE
                     EVDSEYLMELQEKVLTAINESQKNMQEVNLKKAEYCLDINVYRRVDIDNEIKMMPNLEV
                     KVDKTVTLLKFVNQEDNPVGFIVHYPCHANVANINYINGDYPGVLMKLLDNHYNTTSMF
                     LQGCTGDIRPKIIVGNEFFSGDIERVEQLANQFYDSIITQEERLKYENLELDELTIKKH
                     MLNLNINPYLNDRELEKELTSEDELKRQWSKAIIKKKNRNYETLVITEICFGKELTILG
                     YNGEMSGEYSRFAKKITDKDVLSIGYTNGMIGYIPTSIQLKEGGYEPEGSTWYFALSGQ
                     LECKNEEEIKVEIRKILED"
     gene            complement(20918..22144)
                     /locus_tag="HYG85_RS07275"
                     /old_locus_tag="HYG85_07185"
     CDS             complement(20918..22144)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018877.5"
                     /locus_tag="HYG85_RS07275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07185"
                     /product="AGE family epimerase/isomerase"
                     /protein_id="WP_212692917.1"
                     /transl_table=11
                     /translation="MRETGYYKEQIEKDFWPYWEKYIDTTYGGVLNCINNYGDKIINEK
                     KYSWSQGRFLWILSSLYELSIKGILDIDKNRLKNYMDGNLRFILDNCLLEDYSTVFLLE
                     RDGTRIKDKKTGRYDTSIYSDCFIIIGICKYVQNIEDESLVKTILNILNNTTNKISSKH
                     FYTEPYPIPEGYETHAVNMIMVNTLYEVIQTLDKYSMKYDKYVEQANNMINTILYKLCE
                     DGLIREFVYKKGSKNKRLLDRHVTPGHALESMWFIIEYLEKYQDIRKHIDTIGDISIKS
                     FDIGWDEEFGGLLRFVDREGGVPKGESQETSFENLIMDTHDMKIWWPQSEALVIFHKLY
                     QLTGNEKYLERYNKIKDYVFRIFPNEEIGEWIQIRLRDGSPLEKVVALPVKDPFHIMRA
                     FIKIIESEE"
     gene            complement(22214..23698)
                     /locus_tag="HYG85_RS07280"
                     /old_locus_tag="HYG85_07190"
     CDS             complement(22214..23698)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006778607.1"
                     /locus_tag="HYG85_RS07280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07190"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_212692918.1"
                     /transl_table=11
                     /translation="MQTLDYVAVIGFFVVMLGIGFYSLKSVKNSEDFFVGGGKIPWWLS
                     GISHHVSGYSGVVFVAYAGVAYQYGLSLYFWWGVNIALAVIIGSKLFIPRWPKLRRALG
                     IQSPTEYLKLRYNKASQLIIAIAGVIVKLFDVGAKWAAMGLLLNGFTGLPVWTGIIISS
                     VVSLIYIAVGGLIADLWTDFAQFVVQIVAGLVLFVSTIIHLGGIDSIFNIWKQLPAENS
                     RMFVEGTGSYSFVWSILFFFVILLSYSGGTWNLATRFISVKDDVAAKKAGRLSAILYLI
                     WPLILFFPMWAGPVIMPGLEDPAAQLYPGLTKMFLPQGLVGLVLASMFANTLSMCTSDA
                     NTISAVLTRDILPEISDKFKNLTGKRSLYYARITTIAFTALTIIFALYRDVFGDVIGLV
                     LKWFAALLGPTAIPLLLGLMPQFKKADGKAAVSSIIGGLAVFAFTNLGLVTIHPTINLI
                     APLAVSFIIYCLFAFVINKDKEVKPEVEELMKSLSE"
     gene            complement(23686..24477)
                     /locus_tag="HYG85_RS07285"
                     /old_locus_tag="HYG85_07195"
     CDS             complement(23686..24477)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="HYG85_RS07285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="HYG85_07195"
                     /product="hypothetical protein"
                     /protein_id="WP_212692919.1"
                     /transl_table=11
                     /translation="MNKHSVLYLIILIPFIISAAILSFLLREQNIIYIFMTILFVVVGI
                     VLVLKFSNMPMKLKKYELGKEIEISQLGINDKNIKVYQSKTLDEVDFMIHPKDVVLNIF
                     DKNTYIVISQAFYANNKKSIIEMLIRSEVKRVRENYYLKSMMILLWPTFIVVNLFLLSI
                     HINIELVHIVSSNLKMWLIPTMIVLSVIGNIKWFNNYVSRVEEKLDNELLSMYSYSEVT
                     DYIDVTEKYIGGVNEDKVGIYEGVVRARKKNLEKGKNICKL"
     gene            24735..25880
                     /locus_tag="HYG85_RS07290"
                     /old_locus_tag="HYG85_07200"
     CDS             24735..25880
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1108: ROK family
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012692.5"
                     /locus_tag="HYG85_RS07290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="HYG85_07200"
                     /product="ROK family transcriptional regulator"
                     /protein_id="WP_212692920.1"
                     /transl_table=11
                     /translation="MKGLSNRTLRPLYRRKVIKTLLQYGPISRTDIAAKLNISKATVSS
                     ISEELLKKNLIAESSIAASTGGRKAILYDINRNGGYIISLEITPTYISGTLLDLHVNMI
                     SDTCSETNKEYSSSFNIILETINSLIKEMPKEQPIIGISINFRGTVSKDNVIKYFDYDS
                     WRSRNLLEDLSKHYSCLINLNNEANARAYYNSVHLDNSDLTLITMGTGVGLGIVEDNQI
                     YLGYHGYAGEIGHIIVEPDGIPCPCGNKGCLESYISTIEILKRLSTKKNKAITINDFKY
                     LYSQNDIDVLEVVNDFYKYLAIATNNVINIFNPKYMILSSEIIDSIPNFIEIFKQKLNS
                     KVSDYERLIIFSNNRSGAIGGAYLLLRDFFDIEFYIKNGNK"
     misc_feature    complement(26110..26120)
                     /note="TFBS match to HypR, L-hydroxyproline utilization
                     repressor, confidence: weak, score: 18.94"
                     /tool="antismash"
ORIGIN
        1 ataccccttt attattttgt tcttgccaat actctctacc tttaaccgtt atcctactcc
       61 cacctctacc tcgaccaata attacaaaac caagatctgc taactgtatc agtatttctc
      121 taacctgttt ttgagaaata accaaatgtt gttttttcgc catttgcaga attttttcac
      181 gaccaatata ttcatccctt tcacttgctt catacaattg ctccaataca aactcaaaca
      241 aggaagttga cttttgatta ggaattatct tatctaattg gtcattattg ctatttatta
      301 ttttttcttt tttttcacaa atcatatttt tcattttaaa catagtcggt ggtaaatcct
      361 caacctccac catctgtttt cccagatagt taaaatactc tactgcattt tgaagctccc
      421 taacattacc aggccaagaa tagtgttgta gaaaattctt cacttcttct gacaactcaa
      481 aagttgcatc aaacacagtt ttaaaattat caagaagcag caaaatgtca gtaccacgtt
      541 ctctaagtgg aggcaccaaa actgtcaacg cattcagtct gtaatataaa tcttttctaa
      601 aacttccatt tttaacgttt tcctctagaa gttcattggt cgcagctaca atacgtacat
      661 caactctcac aattcgacta ccaccaaccc tcataacctc tccttcttgt aaaactctaa
      721 gcaacttaac ttgcattgca agactcatac cctcaacttc atctaaaaaa agagttcctt
      781 gatgagcaaa ttcaaataag ccaagacgtc ctcctttttt tgctcctgta aacgctcctt
      841 cttcataacc aaacaactca ctctccaaca aattctcagg cattgctgca acatttatag
      901 gtataaacgg accatttgaa cgcttagatg cttgatgaac cgcatgggcc aacaattctt
      961 taccggtccc tgtttctccc acaatcaaaa taggactctc tgtaatagcc attcttttta
     1021 gtatttcttt tacacgctta ataggttctg ccacaccaat tacgtcatca aatgtgtatt
     1081 tggcataatg ccctttttgc agcaactgct ttctcaattc attttgccgt gattcttgct
     1141 cattgaatcg ttgaagggta gcaaacgcac caatacattc attttttctc ataaccggga
     1201 taacagcgat agaaatattt gaaccataca atttggttac tgattcagga atttcttcct
     1261 tattttttaa tgcttgataa aacggaatgt agggaaatac atcttctcct cttttccaaa
     1321 gtacgaattc ctctgacacc ttagcaattt cacatgcttt tttgttacaa gcaagtattt
     1381 cccctttttc atttactcct attaatcctt cattcaatat ttccataaga acatgaaact
     1441 ggctttctct acttcgagat ttcgcataca tcaaatcgaa actatagtga tttgaagcaa
     1501 caattttagc ataattcaaa aaaggctctg tttccaataa attctccaga ttcagtcgaa
     1561 gcgccatctc aatcatcatc ccatatgaac atggacggtg atcacaatct ataaccattt
     1621 taacttcatc aggcacataa cgtgattctc caggtgtcaa tgcaatgtca accttctcat
     1681 ctaatatggc tccaggataa aatggaataa accgtaaatg gttcactcca agcgcattca
     1741 gttgagtaat tgcttcacga gccatagtct cagttacgtt taccaacaac acagatgtac
     1801 cttctggaat tttccataat tgttccaatg ttttccatag gaaagtaact tcaattgaca
     1861 tcacttcgct atctaccggc acatggcgat caacttcttc tgtagagcca taagcatcag
     1921 ttgaaatggc aaataaatca gctcttggca actttcctat agcggatccg tcacgcacac
     1981 tatatacaac aatttcggca tattcaccga acaaactttc tacttcttct gcatatgacg
     2041 caccagccaa tggatccaag actactaccg aaatttgttt tttcataaac atgaatatct
     2101 attcccttca tatttgtata gactcaaaaa tcaataatca attatttgat cacatttttt
     2161 caacaactcc aaaagccttc aaccattgtc ttgctattaa tgcatgtcct gcttgtgtag
     2221 gatgaactcc atccaaagtc catttctcca taggctggat tgttgctgct cttgcaaata
     2281 taccatctag aggaataaat tcagcattga actctcttgc tagagatctt actacatgga
     2341 ttttagggtc taagtcttct ctccatttat cctgcccagc agaccagcct tctgattctt
     2401 caattacagg taataagaaa ggttccataa tgataatctt agcttctaat ttttgtttta
     2461 tattcgtaag aatctgtcta tatgtaattt caaagctatc aactgaagta gggtcattac
     2521 tatcatatct acgccagcaa tcattgatac ctatcaatat ggaaactact tctggtctta
     2581 ggtcgatgca atcttcttgc cacctttttt taaggtctga tactctatta ccgcttattc
     2641 ctctattaag aaatcgtaat tgtttttctg gatgtaatgc tgttaaccat gatgcaacca
     2701 tattagcata accaaaacca agttctaaat attcattact tgtccttcca caatcagtaa
     2761 cactgtctcc ttgaaataag attaatgaat catctttgac attatttatc atatatatta
     2821 ctcctttcat ttattcgttt ttttccatct aataaatatt agcctcatta taacatgatt
     2881 atattatatt taatatccta catattcaat tattacactt agatatttat ttagaaatct
     2941 attatttatt gtttacatcc ataattaaaa ttaatattct tccaattgta gaatattctt
     3001 cttatgatta gcccaagata aatatgaaga aaccataaaa acaatattta ggaggatgta
     3061 tatatggaca atgctatgtt ttgttatcaa tgcgaacaaa cagcaggggg taaaggttgt
     3121 actaaaatgg gcatttgcac caaagacccg aatgtagcta aaatgcagga cgttctaatt
     3181 ttcctattaa aaggcttagg ttactatgca acaaaattaa ttgaagatgg acaggttata
     3241 cctagagaat taggagagtt ttgtacggag tgtgtattcg caacacttac caatgttaac
     3301 tttgcaccag aaagattcgt tgaatatatc aaaaaaacca attactacaa aaaagactta
     3361 atgaataaag cttcaacttc tgatgcacct gaaggagcag attatattgc tcctgaaaca
     3421 aaagaagaga ttctcagtat tcccaatatg aaaaacttag gtgttatgga cgacgaagac
     3481 ttagatatgg atattcgttc tttaagagag ttgttaatat atgggataaa aggtatggga
     3541 gcttattttc atcatgcata cgtacttgga aaatatgatg ctgaaatagc taatttcatg
     3601 tttaaggctc ttagttctac ccttgataga gatttaaccg ttgaagatta tttcaacctt
     3661 aacatggaac ttggcaagac caatttcaaa tgtatggagc tgctagatgc agcaaatact
     3721 ggtgcttttg gtgatccaga acccactgaa atgctcataa ccaagaaaaa aggacctttt
     3781 attgtagtgt caggtcatga tctaaatgac ttaggagatt tacttgaaca aactgaaggt
     3841 aaaggtatca atatatatac ccatggagaa atgcttcctt gtaatgctta tccaggatta
     3901 aagaaataca aacatctaat aggaaatttt ggtggtgctt ggcaagatca acaaaaagag
     3961 tttgataatt tgcctggtgc aatattaatg acaagtaatt gcttaatgaa acctagaaaa
     4021 agttataaag acaggttatt cacttcaagt attgttggct ggcctgatgt aacccacata
     4081 cctactgttg atggtcataa ggattttaca cctgttatag aaaaagcttt aaaattagaa
     4141 ggcttcactg cagatgaacc agaaaaaaga atacctatgg gatttgccag aaacgctgtc
     4201 ctaagtaatg cagatacaat tgttaatgct gtcaaagagg gtaaaataag gcatttcttc
     4261 ttgattggtg gctgcgatgg agctagacct ggaagaaatt attatacaga atttgctgaa
     4321 aagacaccaa aagatactat tatattaact cttgcatgtg gtaaatatag attcaacaaa
     4381 ttagaccttg gttctatagg tccattccca aggatactgg atgtaggtca atgtaatgat
     4441 gcttattcag ctattaagat tgctttagct ttatcagaag catttgaatg tgatgtgaat
     4501 gatcttccat tgtcctatat tataacatgg tatgaacaaa aagcggttgt ggtattactc
     4561 acaatgttat accttggttt gaaagatatt tatcttggac ctacattacc tgctttcata
     4621 actccaaata ttcttcaagt attggttgat aaattcaatc tacagtctat ctcaacacca
     4681 gaccatgatt tacaaaccat tcttggttaa gataagacaa gttcatattg ctccaaatat
     4741 aaaagcacag atttctctgt gcttttatat tttattatcc ttctatacat atatgatatc
     4801 tgaataatta tcttcttcca tgccatatag tctgcctctg cctcttcctc tatatggtct
     4861 gtaataaggt cttccataat agtaaggtct tccataatag taaggtcttc catagtaata
     4921 aggtcttcta taatatggat atcttacata ataggggttt cttctataat agtagggata
     4981 tctcctgtat gaatatggat aatacctagg gtatctgtat cggtaaggac gtctgcctct
     5041 gccgaatctg gtagcttcaa tttcttcgtt aaacatatat tatccttctg ctttttttac
     5101 tattatatgc atttgacatt actaaagtga aagagcctaa catatatact aaaacataca
     5161 ataactattg ttaaataagt tttttgtttt ataatttaat taaatgatat tatttatgtt
     5221 ataggctttt attaaaaagt ataatttgat acaataccag taacgattat ctctacgtta
     5281 taaaaagtta tgaaaggatg tatgaaaatg gctgaaatta cagtaaatga acgtatagaa
     5341 ttattacgtc aagaaatgaa gaaggaaggc ttatctgcct atattatccc cagtgctgac
     5401 ccccatcaaa gcgaatacgt agctgaatac tacaagagca gagcttacat atcaggattt
     5461 accggttcag taggaacagt tatcattact atgtcagaaa gttgtctatg gactgatggc
     5521 agatatttta ttcaggctga aaaacaactc agtgatagtg aagttgttct atataaaatg
     5581 cttgaaccag gtgtacctac atatcaggaa tggttgaaag ataacattaa ggctggtgaa
     5641 aaaataggat tcgaccagcg tttattctca gtgaatgaca tgaaaatgct taaaaatgta
     5701 ataaataatg ataaaataga gcttgtaggc aatatagacc ttatatcaaa tatatggaag
     5761 aacagaccag ctctacctac tgacaaagtt ttttatcatg atataaaata tacaggttca
     5821 acagctgctg aaaaaattga ttcaatacga aatgaaatga aaaagaaaga ttcagaaata
     5881 tatttgatca gctctctcaa tgatattgct tggctattta atattagagg taatgatatc
     5941 atatacaccc ctatcccata tgcttatgga ataataactt tgaccgaagc tattctatat
     6001 atacaacttg ataaagttcc tgaagatgtt cgagcaatac tggaagaaca aaatattgtc
     6061 ataaaagctt atgaggatat atttgatgat ataaaaatat atactaagga tttaacagtt
     6121 acctatgacc ctactaagtt aaattacggt ctaaagtcaa tgattgattc ttcaagccgt
     6181 attgtagaga cacttgaacc tacagctatt gtaaaagcta aacttaatga tactgaaatc
     6241 atgaatttga aggaatgtga aataaaagat ggtgttgcac tagtaaaatt cttgtattgg
     6301 ttagaaaaag ctgttccaag tggagatata acagaaatta ctgcagcaga gaaattagca
     6361 agtttcagaa aagaaaatcc tctatatata gaagatagtt ttgcaacaat cccagcttat
     6421 caagaaaatg cggcaatgat gcattataaa cctgatgtgg caactaccaa gacattaaaa
     6481 ccaaaaggat ttttcttact tgattccggt ggacaatatc atgatggtac tactgatata
     6541 acccgtacca ttgttttggg tgatataaca gaagaagaac gacatgatta tactctagtt
     6601 gtgaaggcac atattgctct tgcacgtcta gtattcttac atggttctac tggttctaat
     6661 cttgatgtta tagcaagaca gcctatttgg caagaatata tggattacaa gtgtggaact
     6721 ggtcattcag taggtttctt attaggtgta cacgaaggac ctgctagaat ccgtaaagga
     6781 tctagtgatg tagttattga agaaggaatg tatcttacta acgagcctgg tatctacaaa
     6841 gaaaataaac atggtatacg tatagaaaac tctatactag tcaaagaagt aatgaataat
     6901 tctgatggcc gttttatggc atttgacaca atatcctatt gtcctataga cttaaaaggt
     6961 attgatgtta caatacttac ctgtgatgaa aaagattggc taaacaacta ccaccaggaa
     7021 gtgtataata agctttctcc tcatcttaac gaagatgagt gcttatggct tcaatctcag
     7081 acaaagagta tataatatat atggtatgat tacaacaacc ttatccacta gactaaagcc
     7141 tagctttagt ctagtttttt tattaccttt gtccccatta aaatacctgc gataattgct
     7201 gttattggtg ctactattac taacccaata cttccgatca gtgttctcat tatctctgct
     7261 gatattattt tcatgtttat gattcttgta aagcttgaat cccttatctg aaatagcata
     7321 agtaatgtta ggtaaccccc agagtatgca agaagtaatg tggttgtcat tgtacctatt
     7381 acgtctctgc ctacattgaa tcctgatttt ataagttctc tttgggtaat attctttttt
     7441 ttgtttttta tctcctggca ggctgaagat acatccatcg ctatatccat tgcagctcct
     7501 gaagacccta ttataatggc tacataaaaa atatatttca tattaaggtc aaaatatcca
     7561 ctgaatacaa ttgtttctgc atatggagat gtcattccca ttaatcctaa tttatcccca
     7621 actaccatag tcagtactag agttatcaac aaacctgata aagtacctaa gaatgctgat
     7681 ataccctttt tattgaatcc tgctactgtg aataatataa tggcagataa agcgaaaaga
     7741 gttataaagg ctattatcaa tggatttttt ccttgtaata gattaggtat caaaaatttc
     7801 cataatatga acatagtaca tataaatgaa agtaaggctt taactccaat acttctagca
     7861 tatataatta gtaaaatcac aaataccaaa aagatgaatc ctagataatt ctgtctatat
     7921 agatccacag cttttgcatc aatgatttta tcattttccg tcttgactgc aataatgatt
     7981 atgtcaccaa tcttataata gttatcataa tccagtttac ctacaagctg attttctaca
     8041 tctatggtct cacctttata gttactattc cctgcaataa ccttcaattc ttgaaaccca
     8101 attgctgaaa cacctgcttt tacaacatta ctatcatcta cttcaataac tttggctttt
     8161 atttctctaa cattcttatt atacttgtct gaggatttat tggattggat gaaaagcaga
     8221 aatataatta tgcataatat accgtatata aatgatactc taattttttt attcattatt
     8281 ataactcctt tatgtctctc tgaaactata taaattaagg aactgttaat aatgctcttg
     8341 tcattattca gccccttaat gtaagaaata ctgtgtagta tttagattag gttaatttaa
     8401 ttctaatcct gctatttttg cagtaatttc agctatggtt gtattatcca taaaaccatt
     8461 ataattctct gctcccacac caatagctga cataggtatt tgagttgctg tatgtgcata
     8521 agatgtccaa taaataccag ctcgctctga taatacatgt gttactgcca ttgctgcttc
     8581 atcgtattta taagcattgc caggatcaat tatctcttta tctaccatgt ccattccttt
     8641 atcaataata gctttttctt catctgataa ctcagtcaaa ccaaatttct caccaatcaa
     8701 attgtaatat tcttttctat caccagtata actgccttga aattcttcta ttgacattat
     8761 tgctttttca agctcttgaa gattcaagaa ataatcagta ttaacgccca ttccaagacc
     8821 acctgtctca tggtcgccaa caacgataat caacgtgtct tgtggatgtt ttttatagaa
     8881 ttcatatgct tcctctactg ctttatcaaa agcaagcgta tccataatag ttcctgatgg
     8941 gtcatttggg tgacaggcat ggtcaatacg tccaccttca atcataaaga agaatccatc
     9001 ttcatctttt gataataagt ctataccttt gctagtaatc tctgctaatg ttggtacatg
     9061 atatttatca ttattttcat catctattgt gtatggtaaa tgtgaagctg tgaatagatt
     9121 aaggtattta tcaccttttt taaatacatc attcctaaac tcttctgctc cttttactcc
     9181 gtatcttact gtgtatcctt catttctgaa atctgctagt acatttttgt catctttacg
     9241 ttttgaatag atttttccac cgaatgcatc tgtttgatta tctgtaaagt ccataggtaa
     9301 gaaatgtctt actccaccac caacaatata atcaactcca ctatccaaaa aatcaactgc
     9361 tatgtcattt tcgttacctc tgctctcatt atgtgatgca aaaacagcag gtgttgcatg
     9421 agttatacgt gttgttgatg ctaatccagt tgccatgcct ttttcttctg cactctctat
     9481 aagagttttt aagttatttc cctcaacatc ttttgatatt accccgttat tagttttatg
     9541 accagtagca agtgctgtac ctgcagctgc tgaatcagtt attaatgtat taagggaatg
     9601 tgttgtgttt atggctgaat gaggaaatgt attcattaca agtttcttgt ctttatcccc
     9661 tgatatctct tgtagatagt actctgatat ctgtctttga gaagtaccca ttccgtctcc
     9721 aataaaataa aatatgtact ttggtgtttt cacgcttgtg ttagctaata cagtgctatt
     9781 tactgctttt aatatgtcat ttgattgtag ggataatgat aatatcatca tagtcattaa
     9841 agcaatacct ataattttct ttttcattaa ttctgcctcc ttggtttatt tactatatta
     9901 atgtaactta tcagtataaa gttattatta tatagttgtt aaatgaatgt aaaattatgg
     9961 tataaaaaaa gaggctatgc ctcatcttca tctaaaatta tcaccttatc aaaaatatta
    10021 aatcccaatc tgtatcctgt tcctgtatca atcctattaa tactgtaaat actccagctg
    10081 ctccatctag taatccagct atatcctgct tatctgaaga ttctttttcc tgatatccat
    10141 aaagctcttc tggattccat aaattcagta cttgttctaa taacttatcc cgtaattctc
    10201 caataatttt atctccactt tcagagtaca ttctctgtac catttgaagt aatcctgctc
    10261 tcccgtgaca aaatgtatca gattctatat tccatttact ctttggtctc atggcagtcc
    10321 ctctgaatgt ttctagtgcc acactcttcc attcttcgtt gttaactgca atgccgctta
    10381 accaaagtgc acgtgcaatt ccaggacctc catagcacca agcttctctt ggaacaacat
    10441 ttcttgattt acctttctta ttctcttccc atgagattct agctggccaa agtggtccat
    10501 attcatcatt ttctttccac tttataatcc agttagcaat cttatgtata gcttcacgct
    10561 gaccagatac ttctactccc ttcatcaaag ctatggacat caaagcaaga acaccaggta
    10621 taccatgtga cattccacag ttgaagtgac cattgggata ttctttacta tcatatccag
    10681 tacatctatc agacgataca taccagccag gtacaactaa tcctttatgc tctttatctg
    10741 cacataactt caccagatat tcaagaatct gttccattgc cagtctcatc tctttttcct
    10801 ctatgaaaca aagtacatag cgcccaatac cgctcaaccc ttgaataaca tcaaactctt
    10861 ttagagaaat accttgtttt agtcttgatt ccatatactg catcatacta ggaaatgact
    10921 ttatgaaaaa tgaattcaat tcttttatga aggtctcata tctggttcca tctcgtgata
    10981 atgctcttgc tgctattatt acaccaccaa taccagtcca aagactaaat tctctgatcc
    11041 cctctttcat gattactctc tgtatctttt gtaagtaggg atgtccaata ctatcccatc
    11101 ccccttgggg atacgcccta tccaaagctc caaacatcac acaaaaacca ctataccctc
    11161 tagctaaatc aataggtgac caaggtatgt aatcttttcc agattcttta cgtatgttaa
    11221 ttaattcaag catatccttt tgaatctgct ctggattaac taatctatgt gctccatcat
    11281 caacaatccg ttgtatctta ttacgaattt cttcatctgt cacctgagac catttcatat
    11341 tgtacttcct ccttatcatt atcactatat gcagatagct gcattttata tagataagca
    11401 tacatactgt cttttttcat caattcaata tggcttcctt gttcaacaac ctctccctga
    11461 tccatcatga ttatatggtc tgcatacttt attgaggtat atcgatgtga aatgaatata
    11521 cctatatgct ggtgaatcag ttctctgaat ttctcaaaca cttggagttc agattctggg
    11581 tctaacatgg aactaggttc atcaagtata tacaaatcag ccttacgcat aaatgcacgg
    11641 gcaatcgcaa ccctctgcca ttgtcctcca gataattgac taccctgatc gaacaacctt
    11701 ccaatctggg tatccaatcc atgtggtaac tgatctacca aatcatctat tccagctctt
    11761 cttgctgatt ctaacaattc gtcatcacgt tcaagtctat tgacattacc aaatcctatg
    11821 ttgtgcctca tattaagttc atactgaaca aagtcctgac aaactacagc catatgattg
    11881 cgtaatgctt cttgattaaa tgaacgtatg gatattccat taataaggat gtcacctttg
    11941 aaatcatcat ataatccagt taatatcttc atgagtgtag ttttacctga accgtttcgt
    12001 ccaacgattg ccattgtttc tccacgcttc aacttgaaac ttacattatt aagagcatat
    12061 ctattagtat ctggatacat gaaagataca tttttaaact caacggtctc aatttccatt
    12121 atatcagtac gtttaccttt atcattctta ctgactttca agtccaagaa tataaatagc
    12181 tgttttagaa aaaggttatg ttgacataat gaaagtatcc cagatataag tgcttgtgag
    12241 ttactctgtg tcatagttat agtctgagtc aatgccacta cagttccgat ttctatctcc
    12301 ctaagaaatg cagacctaag tacaactacc atcattaata cgttagcaat aacgttaata
    12361 acttgaaata taattcctgt actcaacctt tttttggcaa ttttcttatc ttctttatag
    12421 aagcttttga atagaccatt gtaacatctt tgaagatatt tccctagttg atacagtttc
    12481 acttctttga agttcttatc gtttgtcatt agataagaat aataccacgc cttcctcatc
    12541 ttaggtatac gattatactg tactagaaac tcttgctgtc ctatacgaag aaaagaataa
    12601 aatgatgtaa atggtataat aagcaatata aaagccatcc accatctgaa aattatcagc
    12661 attcctgccg cagagataag tgttacaata ccgcttatta atgacatcat ctgctgcata
    12721 atctgatatg gacgatgacc tgcttcattt tgagcaagct tcaaagcatc ttgaacttcc
    12781 gagttctcaa aatccttcaa tgataatgat actgattttt ccattattag cttatttatt
    12841 ctattcatca aaaggacttt gaataagctc tctatataac tctgaatcag attcagcaac
    12901 tgacttaaca gtgtaaatgc aactagtatg gcaaatgcct taaggattac attaaagcct
    12961 tcggtccatg aataagtaat ggagttaatc aagtctttgg tcaatatcaa aacaatgatt
    13021 ggtgaaatac catgaaatag attcaaaatc attattgcaa tcaaactttt tgcatctgta
    13081 gcccataaca gccccatgat acgaggccaa tacctaaacg attttaatat attagctata
    13141 gacattacac ttgaatcctc tctatctacc gccattatgt tcacctcctg cgaatgtata
    13201 ctaaattgtg tagcgtatga cgtaccaaag taagtactct cgtttcatca cctctatcaa
    13261 taccgtataa tctgtttata tgaagatgga ttatactatg cattgcatca atggatttaa
    13321 cataataatc tccactaagc tctttcttag ataattgttc tccataataa ttcaatgtat
    13381 tacttcttgc ctgcaatgct ggtaataaga attgtcctgc ttcatgtctc ctaagctctg
    13441 caaatccatc tcttgtatcg cctaatttca tatacagtga cctctttgac ctaaatagat
    13501 caagataatt tttatagtta acaatcttat ccaagaaagc aagttgttct tcaaaagtca
    13561 atccaaattg ctccatgata tcaataatac ttataactgc caataaatct ttttctatag
    13621 gtaaaatacc ttgttcattt aattttatcc aatccattac aattttgctg tctatgcaaa
    13681 accactgctc tgcgatgttt attaattccc gaccaccata tcgttcaatt tcagggtcat
    13741 atgtatcaat aaccatacgt gaaagcatac cttccttcaa acaattattg gcaaaaatat
    13801 tgagttgtgg taaaaactca ctttgtaatt tcttaggttc accaaaaaaa cgtaacctta
    13861 tatgtccatc agggtcagca tatctcatat agaaactaga cccaatccaa ccattctgct
    13921 ctgctttata acagaattct cttaatcgac ctcccaaaaa ttcctctata cgattccagg
    13981 ctccatacca tttaacatac atccattcac ttcctgggag cttaaaacgt tcagcaaggt
    14041 caattggttt atactgcctt ttaggtattg attccctatt ttttattgca ggatttctaa
    14101 tgattggaaa aacaaattct gtataataac taccctcttg acttttagga agggctccta
    14161 attcatgccc caattcagtt aaaataattc cttgcccaaa cccaagctta gcgaattctc
    14221 tccgtatttc gtcaatatgc tcactctcat tcaaatccaa caataatcta ttatctgttt
    14281 gagtcaagta gacatacctt ggaagtcgca attctttttt gtatgtatca aatttttcta
    14341 tccattcttc tttattcata ttatcttcaa tagggaatgt ttccttatta ataatccatc
    14401 tagcagggga taaaatacaa cgtccatatt ttatacgagg caaaaatggc aatgaattaa
    14461 attctcccca atgtaaattt tcaatattcc tctgcctctc catagacaat tctctaagga
    14521 atctatagac attaggtgaa ttagatccat tgaacatatg attaactaca gttataacct
    14581 ctttaccaag ttttaatgac ctaagataga atcctctctt atctatgcca accaccaaat
    14641 ctgataaagg aataatattc tctggtttct tagaagatgt tgtccccata acaatctcgt
    14701 agttacgatt atcataggtt aatactacat tagctgctct gccatctatg ggtaagtaaa
    14761 ccaattcggc taatattcca tctgaacaca tctcttgttc tgatttccca aattttttta
    14821 gctcatcttg aaactcagaa cccataatgt cagtaaatct cccaattgac cttcctgcac
    14881 cataggaaag ggctgttgct ccacttataa gagtataatc tcctgcttct acactttctt
    14941 ttgaatcagc agccaatgaa aaaaagagtt caaaagagcg aggggcatag cggctgtcaa
    15001 cctcttctcc tgctaattct tctattttct catcatctag aacaatttct tgttctccct
    15061 ttaataaggt catagttaac cattgtgata acaaatactt cttccgttgc tgaaactcag
    15121 ttctattttc ctttgggttt cttttggaag gtggatattc atatgtagct ggtgaaccta
    15181 atcctatctc ttcatccaat aactctaata atggaacctc tcttgatgat ccatattttt
    15241 ttatgaaatc atttctgtat tccaagaagt gtgataatcc gtattcatta tcactgattt
    15301 tccacagtac ttctgctgct ttttccactt cttctttaat agaaatgggt aagactactt
    15361 catccttttg aatcttaaga tcaacctgta gataattttt actttcggct atttttttca
    15421 tcttcttaat tatgtttcga tataattctt cgccttctcc taatagggtt ctatcataca
    15481 tatctatcat gaaggatatt tcttgtaact gagcttttaa tttatctatc ccttttatat
    15541 cttctatacg ttgtaatagg taatttaatg gatttgcctc tattagaggt ggacgtaaat
    15601 tggaaattaa cagctcttgt ttaaataact gataaacaaa ttggtttatt tgctcgcgtg
    15661 gcgtatctgg atattcaaca tttaacttat taactaattc tttgtaggtc ataggtttct
    15721 ctgataagtt aagggcttgt ttgacagcgc ttgtagtccg tactgatgta cgttccattt
    15781 cattgccttt ccccttagcc tgacctaaat tcgttaagta tggaaggtat gttctattac
    15841 ccactttata agccatagta tttgccatta ctattagttg cttgattagg ttagggtcat
    15901 tctccatttg tgctattatc ttgaataacc agtccatatc aggacgagta cgcttttcat
    15961 gatactcagt actccttaat gcaactttgt aataatctcc gtactctcca tacgccactc
    16021 cagaaaataa accaaaaggt gttggtctag tagacattct tatcaaataa cgtaaaaaag
    16081 ctctggcaac ttgttctctt ttacgggatg gactatctgg tgaaaggtta gttagagcat
    16141 ccagaagtga tatactcgaa acagctattg cttctctgat taagggatct tgtgtaaatt
    16201 cccataattc atctaaaata ggtgcattaa aggatgttaa cttattttca aatacatttg
    16261 tagatagtat aggcgttcgt aatataaaaa aatcaagaca tttgaatata ctctgattac
    16321 tcattattat ctcctttcat tccatataaa catcaaaaaa catcactaag atgttttttg
    16381 atgtttaata ttactttact ctatacatta acaacttgaa gtatgagtgt atccacacat
    16441 attttgacca gtatagcagt cagatgaata acaagtagat gtatagcaag tagatgtata
    16501 acaagatgat gtgtaacaag tagacgtata aagaccgtct aattctgcac cattaatttt
    16561 atcaacttta acttctaaat caaatggatt ttttgccatc gtcaatcccc ctttcatttg
    16621 taaagttcct tacataagga cacaagatta atgagattat gtactcacct tgtaattatc
    16681 ccttaaaaat gcatgcacaa atattataca tagtatgata ttaaaagtca attattaatt
    16741 ttttttattt tcttgttatt ttgacaaaat aacccattat ctttttcaaa gtcagatttt
    16801 ataaatatta ttggttaatt tcaggtatga tttttatata tagctaattt tttgaatttt
    16861 gcagttaatg taaggcaata aaaatatccc tgccagatag acagggatac atataataat
    16921 ttaatactaa ttacatgttt taatttaaat ttatcctata taagaatctt gatctaaata
    16981 tagttttgct tgattatgag ttctaataat tgatactgga acctcttctg taatttctcc
    17041 cttaagcaat ttattgattg cttgatgctt cagttttcca gggactatgc aaaatatttg
    17101 attagcactc attaatgctg gaatagtcaa tgttatagct tgttttggta cttcatccag
    17161 tgaggaaaag catccatcat tcacttgttg aatacggcat gcttcatcaa gtgtaatctc
    17221 ttttatcaat tctttatcct ggaaattggc tacatgtggg tcattaaaag cgatatgtcc
    17281 attttctcct gctccacaaa taactatatc tattttattg ttttttagta ttttttgata
    17341 tttagcaatt atttcttctt ttgtttcatc tcgttctttt agataatata tatttttcaa
    17401 attgatgttg gaaaataatt ctcgctctag aaaattagcg aactttgcac tatggttatt
    17461 attcaaggta tgatattcat ccatatgcat tgcatttact cttctccaat ctacatcatc
    17521 tgcttctttt agatacttga atacgtctgt ttgggatgga gcagcagcaa aaataatgtt
    17581 aacctcttct tgttttttta gtaggttttt gattgaatca gcaatatctt tccctgcggc
    17641 ttttcccatt aactctctat ttccgtagac ttcaaccact agtttatctt tttgaaattt
    17701 cattattgtc tccctcgtta tattttattt atatttatat ctcccataac catcactaac
    17761 gaaatttctt gcttatcatc aaaaataata atatcagcat ctttacctat ttctattgaa
    17821 cctttttgat cttcaatatt tagtaatgtt gcaggattta ttgtcaacat gtttactact
    17881 tcgtccaatg atgcacttgt gttataatac attgttttca gaagaatatc tgaggttgct
    17941 acacttccag caaaagcact tcgatctgtc aattttgcca cattatcttc tacaactact
    18001 tcatatcctg aatctttacc gcctaaggta tataaaccat caggcattcc tgcggctctc
    18061 attgaatctg ttactaaaca tattctatct tttctcttga tcttgtatat taattctaat
    18121 agttctttag gtaaatggct tccgtcagca ataacttcta catagatatc atcaagtaaa
    18181 taacctgctt cgacagctcc tgctactcta tatgcatttt tcctaataac actattcata
    18241 ccactataga aatgaacaag acatatatac ccattttcat aagccttctt aacctcttca
    18301 catgttgcct cagtatgagc tatagaacaa ttgattttct tttcttttaa tacttgtgca
    18361 aattcaagtg ctccttcaag ctctggtgct aaagaccatc taatgattcg atcagttaat
    18421 gaaagaatct tattatactc ttctggttct ggattcctta gatatcttgg atcttgagct
    18481 ccacgttgtc cataagaaaa ataaggacct tcaagatgta atccaagaat atttggataa
    18541 ccttttttgt ttagatcaat gttattaaag atgttcatga aagtgtttag gttctcttta
    18601 gtattggtca aggtagttgg aacaatgcta gttgttccat gtaccatatg tgcataaaca
    18661 gccttatata tagcttcttc agtgttatcc ataaaatcat gccctccacc accgtgggta
    18721 tgtatatcta tgaatccagg agatatatat tgttcttttg catctattac catgtcataa
    18781 ttacaattga aatcttctgt ataaaatatt tgttcaattt ttttatcttt aattagtaca
    18841 gaaccttttt taataccgtc tttttctatt atattcccat tttttattaa tattgttttc
    18901 atctacaaca ccttaatttt atctttgaat tttccaagga attgattatt ccattcatct
    18961 ccgccatcag catttccact catccatact ggaggtttga ttccttgttt cactaacatg
    19021 tcaattgctt caatcactat acaattcatc acatatgcat ttgcaaaggt acttaatgca
    19081 cctatctttt gttcgaaatt atctaatttt attactgcat ctccaacttg tattttacta
    19141 tcaatagcat aatcaactat ttcatggaga ttcttctttg atggatgacg agcaatatga
    19201 tcttgtggtg tactttcagc atgctcaaat gaacagatac ctattgtcgt agcaccattt
    19261 tctttggatt ctaacgctgc ctcaattgtt gcagcattaa ttccatatgc attaactata
    19321 attactaagt ctccttctcc tattccataa tcattgatga caacttttcc ataaccaggc
    19381 agtctttcga tttgcattga acgaagtgcc ccatgattaa gcatggttcc cccatccaat
    19441 atagcattaa tatgcattaa tcccccagct cgaaagaaaa tctccattgt agctaggtta
    19501 gaatgtccac caggtcccca aacatagact aacttatctt tttttatgtg ttctgctata
    19561 acctgagcaa cttttaaaat tctgtctttt tcctcattat gaatacgatt gataattcca
    19621 aaaacatgtt catgatattg attcattaca ctcataactc aatcctccaa tatttttctt
    19681 atttctacct ttatttcttc ctcattttta cattctagct gaccactcaa agcaaagtac
    19741 caagttgaac cttctggttc atatccacct tctttcaatt gtattgaagt cggaatatag
    19801 cctatcattc cattggtata acctatggat aatacgtctt tgtcagtaat tttcttggca
    19861 aaccttgaat actctccaga catttctcca ttatatccaa gaatcgtaag ttctttacca
    19921 aaacagattt ctgtaataac tagcgtttca taatttctgt ttttcttctt aataatagct
    19981 tttgaccatt gacgtttcag ctcatcttca ctagtaagct ctttttctag ttctcggtca
    20041 ttcaagtatg gatttatgtt aagatttaac atatgttttt ttatagttaa ttcatctaat
    20101 tcaaggtttt catatttcag tctttcttct tgagtaataa ttgagtcata gaactgattg
    20161 gctaactgct caaccctttc aatatctcct gagaaaaatt catttcctac tataatcttt
    20221 ggtcgaatat ctcctgtaca cccttgcagg aacatgcttg ttgtattgta atgattatct
    20281 agtaatttca tcaatactcc tgggtaatca ccatttatat aattaatatt agcaacatta
    20341 gcatgacaag gataatgtac aataaaacca actgggttat cttcttggtt cacgaatttt
    20401 aacaacgtaa ctgttttatc tactttcact tcaagattag gcatcatctt gatttcatta
    20461 tcaatatcta ctcttctata tacattgata tcaagacaat attccgcttt ctttaagttt
    20521 acttcctgca tatttttttg ggattcatta atagcagtta acactttttc ttgtaattcc
    20581 atcaaatatt cactgtctac ttcttccaat aattctgtaa aattttcact tgtacctggt
    20641 cctgagtgat tatgtgatgc agtaaaaact atattttcat aacttagatt aaatctttga
    20701 cttattcgct tattcattgt atctatgaag tcactgcccc accaaagcaa atcaccataa
    20761 ataattactt tatcttcatc gcttgtccta aagtaataaa ctactgtata aatatcatgt
    20821 ataacatcaa taaacggctc aagacgattt gcataacctg caagtcttat tttttttgac
    20881 ggtgtaatac taatttttga tacccctaac tgcattatca ttcctcactc tcaataatct
    20941 taatgaaggc tctcataata tgaaatgggt cttttacagg caaagctaca actttttcta
    21001 gtggagaccc atctctaagt ctgatttgaa tccattctcc aatttcttca tttggaaaaa
    21061 ttctaaatac ataatcctta atcttattat atctttcgag atatttttca tttccagtta
    21121 attgatataa tttatggaat atgactaatg cttctgattg gggccaccat attttcatat
    21181 catgtgtatc cattatcaga ttctcgaatg aagtttcctg tgattctcct ttgggaactc
    21241 ctccctctct atctacaaat cttaagagtc ctccgaattc ttcatcccat cctatatcaa
    21301 atgattttat tgaaatatct ccaattgtat ctatgtgttt cctgatatcc tgatattttt
    21361 caagatattc aataatgaac cacatacttt caagggcatg acctggagta acatgacgat
    21421 ctaacagtct cttattcttt gacccctttt tatatacaaa ttctcttatc aatccatctt
    21481 cacacaactt atacaatata gtatttatca tattattagc ctgctccaca tatttatcat
    21541 acttcatact atatttatca agtgtttgta tcacttcata taatgtattc accattatca
    21601 tgttaacagc atgagtttca tatccttctg gaataggata tggttctgta tagaagtgtt
    21661 tacttgatat cttattagtt gtgttattca agatattcaa tattgtttta actaaagatt
    21721 catcctctat attttgaaca tatttacaga ttccaataat gataaaacag tctgagtata
    21781 tgcttgtatc atatctacct gtttttttat cttttattct tgtaccatct ctttctagta
    21841 agaatacagt actataatcc tcaaggagac aattatcaag aatgaatctt aaatttccat
    21901 ccatataatt tttcaatcta tttttgtcaa tatccaatat accttttatt gatagttcat
    21961 aaagtgaact taatatccat aaaaatcttc cttgagacca tgaatacttt ttttcattaa
    22021 ttattttgtc accataatta tttatgcaat tcaatacacc accgtaagta gtatctatat
    22081 atttctccca atatggccaa aaatcttttt ctatctgttc tttataataa cctgtttctc
    22141 tcatattaac accaccttga aattaatgaa tatgagaatt gttccttctc atattcacta
    22201 atatatatta tgattactcg gatagagatt tcataagttc ttcaacttct ggtttaactt
    22261 ctttgtcttt gttgatgaca aatgcaaaca agcaatatat gataaaggat actgctaatg
    22321 gtgcaatcaa gttaatagtt ggatgaatag ttactaatcc taagttagta aacgcaaata
    22381 ctgccaatcc cccaattatt gagctgactg ctgcctttcc atctgctttt ttgaattgtg
    22441 gcatcaaacc aagtaacaac ggaatcgcag ttggtccaag tagagcagcg aaccacttga
    22501 gtacaagtcc aattacatct ccaaagacat ctctataaag agcaaaaatg atagttaaag
    22561 ctgtaaatgc aatggtagta atacgtgcat agtataatga tcttttacct gttaagtttt
    22621 taaacttatc acttatttct ggtaatatgt ctctagtaag aaccgctgaa atagtatttg
    22681 catctgaagt acacattgaa agtgtattag caaacattga agcaagtact aatccaacaa
    22741 gcccttgagg taggaacatc ttagtcaatc ctggatataa ctgtgcagca ggatcttcta
    22801 accccggcat tattactggt ccagcccaca ttgggaagaa taggatcaac ggccatatta
    22861 agtataatat tgctgataga cgtcctgctt ttttagcagc tacatcatct tttacagaaa
    22921 taaaacgggt tgctagattc caagtaccac cactataact taatagaata acgaaaaaga
    22981 atagtattga ccatacgaat gaatacgaac ctgtaccttc gacaaacatt cttgaattct
    23041 ctgcgggcaa ctgtttccaa atattgaata ttgaatcaat tccacctaaa tgtataatag
    23101 ttgaaacaaa caatacaagt cccgcaacaa tttgaacaac aaattgtgca aagtcagtcc
    23161 acaagtcagc aatcaagcca cctactgcaa tataaataag tgatacaaca cttgatatga
    23221 taatgcctgt ccatacagga agccctgtga aaccatttaa taaaagaccc atggctgccc
    23281 attttgcacc tacatcaaat aattttacta taactccagc aattgcaata attagctgtg
    23341 atgctttatt ataacggagt tttagatatt cagttggtga ttgaatccct aatgcacgtc
    23401 ttagttttgg ccaacgaggt atgaataatt tggaaccaat aattacagca agagctatat
    23461 ttacacccca ccaaaaatat aaggacaatc catattggta tgctactcct gcataagcta
    23521 caaatactac cccactataa cctgatacat gatgagaaat acctgataac caccatggta
    23581 ttttacctcc cccaacaaag aaatcttctg agtttttaac acttttaagc gagtagaatc
    23641 caattcctag catgaccaca aagaaaccta ttactgctac ataatctaaa gtttgcatat
    23701 gtttttcccc ttttcaagat ttttttttcg tgctctaact acaccttcat agataccgac
    23761 tttatcctcg tttacacctc ctatatattt ttcagtaaca tcaatataat cggtaacctc
    23821 agaataggaa tacattgata gtaattcgtt atctaatttt tcttcaaccc ttgatacata
    23881 gttattaaac cacttaatat tgccaatgac agaaagcaca atcattgtag gtattaacca
    23941 cattttcaag ttagaactaa caatatgtac caattcaata tttatatgaa tagataacaa
    24001 aaacaaattt actacaataa atgtaggcca taacaaaatc atcattgatt tcaaataata
    24061 attttctctg actcttttaa cctcagatct aataagcatc tctattattg actttttatt
    24121 atttgcataa aatgcttgac ttatgacaat ataagtattt ttatcaaata tattcagaac
    24181 aacatctttt ggatgaatca taaaatcaac ttcatcaagt gtctttgatt gataaacttt
    24241 tatattttta tcattaatac ctaattggga aatctctatt tcttttccta attcatattt
    24301 ctttaatttc attggcatat tactaaactt caatactaaa actatgccaa ctacaacaaa
    24361 tagtattgtc ataaaaatat aaattatatt ttgctctctt aataaaaatg ataagatagc
    24421 tgcactaatg ataaatggta ttaagatgat aagatataat acactatgct tgttcatcat
    24481 aatcaacctt tcaatatttg actttataca acacttgaac aaagtgttta taagttaact
    24541 atcaatatct atatccaaca atatgtataa cctttaagaa aaataattat attatcataa
    24601 tacactatat ttcaacttaa ttcaatacct gaattaagtt tttttataaa tatccattat
    24661 ttgatttgct taaaaatgtt ttttttctta taatagtagg tgtattctat atttttacag
    24721 taagaggtga attaatgaaa ggcttatcaa atcgaacact ccgaccttta tatagacgaa
    24781 aagtaataaa aactcttttg caatatggtc ctatatcacg aactgatata gctgcaaaat
    24841 taaatatatc taaagcaact gtttcttcga tttcagagga attgcttaaa aagaacttaa
    24901 tcgcagaatc cagtatcgca gcatcaactg gaggcagaaa agccatttta tatgacatta
    24961 atagaaatgg aggatatatc attagcttgg agattactcc cacatacata agtggtactc
    25021 ttcttgatct acatgttaat atgatctccg atacttgttc tgaaacaaac aaagaatatt
    25081 cttcttcttt taatataata ttagaaacaa ttaattcatt aatcaaggaa atgccaaaag
    25141 agcaacccat aataggaata tctataaatt ttagaggtac cgtatcaaaa gataatgtga
    25201 taaagtattt tgattatgac tcttggcgat ccaggaatct tttagaagat ttatcaaaac
    25261 attactcttg tctaataaat ctgaacaacg aagctaatgc tcgtgcctat tataatagtg
    25321 ttcatttaga caatagtgac ctaactttga ttacaatggg aactggagtt ggtctaggga
    25381 ttgtggaaga taatcagata tatttaggtt atcatggtta cgctggtgaa atcggacata
    25441 ttattgttga accagatggt attccatgtc catgtggtaa taagggatgt cttgagagtt
    25501 atattagtac tattgaaatt ttgaaaagat tgtctactaa aaagaataag gctataacca
    25561 taaatgattt taaatatttg tatagtcaaa atgatattga cgtacttgag gtggtaaatg
    25621 atttttataa atatcttgcc attgcaacca ataatgttat aaatattttc aatcctaaat
    25681 atatgatttt atcaagtgaa attattgatt ccattcctaa ttttatagag attttcaaac
    25741 agaagttgaa ttcaaaagta tctgattatg aacgtttgat tattttttct aataatagat
    25801 ctggagcaat aggaggtgct tatttacttc ttagggattt ttttgatata gaattttata
    25861 ttaagaatgg taataagtga tagtttattg tggttgtgtt agtggttaag aaatatttac
    25921 cacgttttta atataagata taataagata atatatctta tatatactcc attttaatta
    25981 agttatttct taaaaaatgt aggttatata tatgtttcaa aatgtagaaa taacccaagg
    26041 aattggtggt ataataattg tgttggttga aaatttcata cattaaaggt catactttat
    26101 atggaagtag tgacatttca gaaatactct aagtattagt agtaataatg attaacttag
    26161 agatatcagt caaaattagc atatcctaat atttctccta ccttttatta actggaagaa
    26221 acaataagtc aaattggatt tataagctga ataactcaat agaaaaacca acgtgttttc
    26281 aattagctag ctgtttaaaa cacattgatt tattattatt ggta
//
