LOCUS       NZ_CP047645            26356 bp    DNA     circular CON 23-JUN-2024
DEFINITION  Bacillus subtilis strain PMB102 chromosome.
ACCESSION   NZ_CP047645
VERSION     NZ_CP047645.1
KEYWORDS    RefSeq.
SOURCE      Bacillus subtilis
  ORGANISM  Bacillus subtilis
            Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
REFERENCE   1  (bases 1 to 4103088)
  AUTHORS   Wu,J.-J., Huang,J.-W. and Deng,W.-L.
  TITLE     Bacillus subtilis PMB102 suppresses Alternaria leaf spot on Chinese
            cabbage
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 4103088)
  AUTHORS   Wu,J.-J., Huang,J.-W. and Deng,W.-L.
  TITLE     Direct Submission
  JOURNAL   Submitted (13-JAN-2020) PhD program in microbial genomics, National
            Chung Hsing University and Academia Sinica, No. 145, Xingda Rd.,
            Taichung 40227, Taiwan
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 07-JAN-2019
            Assembly Method                   :: Canu v. 1.8; Pilon v. 1.23
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 120.97x
            Sequencing Technology :: Oxford Nanopore MiniION; Illumina GAIIx
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_018141065.1-RS_2024_06_23
            Annotation Date                   :: 06/23/2024 04:52:35
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 4,262
            CDSs (total)                      :: 4,141
            Genes (coding)                    :: 3,965
            CDSs (with protein)               :: 3,965
            Genes (RNA)                       :: 121
            rRNAs                             :: 10, 10, 10 (5S, 16S, 23S)
            complete rRNAs                    :: 10, 10, 10 (5S, 16S, 23S)
            tRNAs                             :: 86
            ncRNAs                            :: 5
            Pseudo Genes (total)              :: 176
            CDSs (without protein)            :: 176
            Pseudo Genes (ambiguous residues) :: 0 of 176
            Pseudo Genes (frameshifted)       :: 121 of 176
            Pseudo Genes (incomplete)         :: 64 of 176
            Pseudo Genes (internal stop)      :: 21 of 176
            Pseudo Genes (multiple problems)  :: 27 of 176
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 05:29:07
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3346175
            Orig. end                         :: 3372531
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP047645.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Ph.D. Program in Microbial
            Genomics, National Chung Hsing University and Academia Sinica, No.
            145, Xingda Rd., Taichung 40227, Taiwan.
FEATURES             Location/Qualifiers
     region          1..26356
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="8"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..26356
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..26356
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:16356](-)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..16356)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(812..826)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     strong, score: 25.92"
                     /tool="antismash"
     gene            1048..1605
                     /gene="opcR"
                     /gene_synonym="yvbF"
                     /locus_tag="GSN02_RS17385"
                     /old_locus_tag="GSN02_17390"
     CDS             1048..1605
                     /codon_start=1
                     /gene="opcR"
                     /gene_synonym="yvbF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391264.1"
                     /locus_tag="GSN02_RS17385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17390"
                     /product="opuC operon transcriptional regulator OpcR"
                     /protein_id="WP_003228345.1"
                     /transl_table=11
                     /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNRK
                     PMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISLFA
                     ANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLSRLI
                     EFFESEEVFRYVPKTKESSSLK"
     gene            complement(1623..2258)
                     /gene="yvbG"
                     /locus_tag="GSN02_RS17390"
                     /old_locus_tag="GSN02_17395"
     CDS             complement(1623..2258)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /codon_start=1
                     /gene="yvbG"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391265.1"
                     /locus_tag="GSN02_RS17390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17395"
                     /product="NAAT family transporter"
                     /protein_id="WP_010886614.1"
                     /transl_table=11
                     /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARKA
                     AILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHHDE
                     HKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALTFLF
                     FHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS"
     gene            2408..3022
                     /gene="yvbH"
                     /locus_tag="GSN02_RS17395"
                     /old_locus_tag="GSN02_17400"
     CDS             2408..3022
                     /codon_start=1
                     /gene="yvbH"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391266.1"
                     /locus_tag="GSN02_RS17395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17400"
                     /product="PH domain-containing protein"
                     /protein_id="WP_003228342.1"
                     /transl_table=11
                     /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFLI
                     KTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIKFK
                     LGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHTRPE
                     HVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYMNN"
     gene            3154..3852
                     /gene="yvbI"
                     /locus_tag="GSN02_RS17400"
                     /old_locus_tag="GSN02_17405"
     CDS             3154..3852
                     /codon_start=1
                     /gene="yvbI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391267.1"
                     /locus_tag="GSN02_RS17400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17405"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_038829386.1"
                     /transl_table=11
                     /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHPAQTGAAAKQAAKQ
                     FGSFVLSVLKRPYQECKATGGEQLISAVITLVLFSLLTPLMFYILFSDGPGSVSFTAIF
                     LEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFFLLH
                     TDICFTILAVGLIGAFFAIPPAMLGSYQHSYKGKIDVIYSTIVIYLIICVTFQLIIEHY
                     VKEIFRYMLF"
     gene            complement(3888..5705)
                     /gene="yvbJ"
                     /locus_tag="GSN02_RS17405"
                     /old_locus_tag="GSN02_17410"
     CDS             complement(3888..5705)
                     /codon_start=1
                     /gene="yvbJ"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391268.1"
                     /locus_tag="GSN02_RS17405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17410"
                     /product="zinc ribbon domain-containing protein"
                     /protein_id="WP_101501470.1"
                     /transl_table=11
                     /translation="MFFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQA
                     PRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIATLL
                     TPVNDNLKLTKNSVKPFLTYLKDHPDKKDELFASLREETAQKDIVYAEKDGKSLLVFDH
                     YDLKVAPVYFEVTSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLKNDVV
                     DLVKKEDIQAVGDNSFRVDLSLEADDVTFSLADDIKSGKGDLLINGKSIHKDPFKSVTY
                     GPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIVKTTKQY
                     SKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFALSQKNDG
                     TWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAESTFQSAGT
                     NIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQADAVNQNNFS
                     LMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITIKTYEEFYITK
                     SGGSPKLRTYNWTYTGVVKNGRIYLTSIQ"
     misc_feature    5753..5766
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.83"
                     /tool="antismash"
     gene            5825..6292
                     /gene="yvbK"
                     /locus_tag="GSN02_RS17410"
                     /old_locus_tag="GSN02_17415"
     CDS             5825..6292
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="yvbK"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391269.1"
                     /locus_tag="GSN02_RS17410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17415"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_077671075.1"
                     /transl_table=11
                     /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTAW
                     AGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKELGADTIEIGT
                     GNSSIHQLSLYQKCGFRIQAIDHDFFVRHYDEDIFENGIQCRDMVRLYLDL"
     gene            complement(6346..7268)
                     /locus_tag="GSN02_RS17415"
                     /old_locus_tag="GSN02_17420"
                     /pseudo=""
     CDS             complement(6346..7268)
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611387.1"
                     /locus_tag="GSN02_RS17415"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="GSN02_17420"
                     /product="integrase core domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MRLAGVLMKEIMQKFNIKNKPQV"
     gene            complement(7646..7816)
                     /locus_tag="GSN02_RS17420"
                     /old_locus_tag="GSN02_17425"
     CDS             complement(7646..7816)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="GSN02_RS17420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="GSN02_17425"
                     /product="hypothetical protein"
                     /protein_id="WP_163136571.1"
                     /transl_table=11
                     /translation="MKNYKGDGAVFLVIGFCLGLFMGVVFDILPYGLSLGILIGSLIDF
                     YFYARYKNNKK"
     gene            complement(7857..10004)
                     /locus_tag="GSN02_RS17425"
                     /old_locus_tag="GSN02_17430"
     CDS             complement(7857..10004)
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="GSN02_RS17425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17430"
                     /product="peptidase domain-containing ABC transporter"
                     /protein_id="WP_101501471.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 2.7e-36, bitscore:
                     122.3, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVKKKKRIPIVKQLQQTECGLCCCAMLIRFYNSNETLFELRSFL
                     EAGRDGLTIKQLKNLLVHKGFKADIYKSTIPGLKKINVPFIAYWNNEHFIVVEKTKKNF
                     YYIIDPANGRRKLTEEEFRKGFSSYILYAVPSENFTPNKRKDKNVWFGVLKNITNYKLL
                     FSIIVFLSLISYLLTLYVPILVQKLIDTSIEHNNLNSISNIVWITFLISILYGMFVLFR
                     GLKMISLNIFLSKNLVVDTFAHLLKLPFKFFDLRSPGDLLFRLNSMNGFRELLSTQLIS
                     GLIDLGAVVFILAYMFFKSIPLTLITILIFAINTIFMFLTRPAVAQAIDDEVAEQSKSQ
                     AIQIESIFSIAAIKISGMENEIFSTWNNSFNDVIKRFKKRSILQNIVNTVTQVFQTIAP
                     LVILILELLLFFDNKFTMGEVIAYHSLSVTFFGLTTSLFGTYTQFILATSYLERVKDIT
                     ETECEKNFENAVNLKLRGNVKLENVSFSYTKHSPKVLKNISLEIREGQKIAIVGSSGSG
                     KSTLSKLIMGLYDPTEGQICFDSIPLEKLDKKQLYKQMGIVPQDITLFNSSILKNITLN
                     NKNTSIEKVRKVAKAAQIDKEIESMPMKYNTPISEMGMNLSGGQRQRIVLARALLNDPK
                     ILILDEATSSLDLVNETLISKYLSEMGCTRVVIAHRLSTIMDSDFIIVLDKGEVVEIGK
                     HEELIALEGVYSNLYRSQMKR"
     gene            complement(10001..12949)
                     /locus_tag="GSN02_RS17430"
                     /old_locus_tag="GSN02_17435"
     CDS             complement(10001..12949)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="GSN02_RS17430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17435"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_163136660.1"
                     /sec_met_domain="DUF4135 (E-value: 1.3e-86, bitscore:
                     289.0, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 9e-58, bitscore:
                     193.6, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDISYENNNFIRDAVINFSSPTNEVEKLRIKNKDYFGNFYTFFLD
                     FYQQRLFNTLENASKENNLKLNKQKIISSALEAFSQELIQLCIRTLIVDINDRKEKGLL
                     EGKDSKLRYKNYNNLIFKSEYVAEILNKYPVLTYLISSRISNKILYLKEVLENLRKNRQ
                     DIYRELRIEFDEVSNIYFSSGDTHNGGKNVLIIETNQGKIVYKPHSLSPDILFNSIVDY
                     VNNSDKILKKIYKIRTLNYKDYGYQEFIDYKECETSEKLNFYFYRVGVSLSIFHIIGCD
                     DLHHENLIAHGEYPVVIDLETLIKNNSIYKPRNNNLIDNFHEDINYSVLGTMLLPLNLQ
                     TSIFDFDLGGISNDENQTSEIWKSYIIDFEGTDEIQLTKKSVIMNSTQNRATYNGKAAD
                     PKNYIEEILKGFTDCYNFVLENISGFHDLVKKVGSSNLEVRQVLRATSIYARFLEASTH
                     PNYLSSFEERKKLFKKINIAEGVTDKFSKKNLYELESLMCNDVPYFSTMYNSLDLICNK
                     STSIVNFFRESLLDVVLNKIKSISKASLKKQQYYIRMSLTTTIKDSWKKTNKHNKKYRP
                     KLFGNNNKNYLECATEIGDLFLETAIWNNDRSKCTWVAPIISENNKVKLGPLNFDLYEG
                     GGVILFLALLGKENGKKEYFDLALAGMRGIEELFLSDDKMDDRLSLFTGIGSLSYIYYH
                     LYTHTNDYKYYEKFKKYIKKINEMNISGDIALDIVGGVSSLIVFLLNLYKETKLDILNS
                     VCCKLGNTLYQCLENDKHNYLTGLSHGYSGFTWALCYLGHITKEEKYTTLGKELLKIEN
                     KFFDLHTSNWKDLRVGEGNSDPVYWCHGAGGIALSRAFLKDLLKNKENVVDKEIDKEVD
                     RDLSSAICKLLSDGFKKTTDHSLCHGSFGNIDILLKLSEFLNDIDLQEVAFKEAQNAIN
                     YIRDKGFIPGLQDHFDLNTFMLGLGGVGYSLLRLHNPVNPSLLAMEVRSYNE"
     gene            complement(13018..13218)
                     /locus_tag="GSN02_RS17435"
                     /old_locus_tag="GSN02_17440"
     CDS             complement(13018..13218)
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038161.1"
                     /locus_tag="GSN02_RS17435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17440"
                     /product="class II lanthipeptide, LchA2/BrtA2 family"
                     /protein_id="WP_090557569.1"
                     /transl_table=11
                     /translation="MKKDMVKNASGFIEEDELISLANGENATGGGTPVTAIITALTGTT
                     FTVTLSAASCPTSACTNLCNK"
     CDS_motif       complement(13129..13218)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKKDMVKNASGFIEEDELISLANGENATGG"
                     /locus_tag="GSN02_RS17435_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(13018..13128)
                     /prepeptide="core"
                     /locus_tag="GSN02_RS17435_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-5.20"
                     /molecular_weight="3296.8"
                     /monoisotopic_mass="3294.8"
                     /core_sequence="GTPVTAIITALTGTTFTVTLSAASCPTSACTNLCNK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKDMVKNASGFIEEDELISLANGENATGG"
                     /leader_location="[13128:13218](-)"
                     /alternative_weights="3314.8"
                     /alternative_weights="3332.8"
                     /alternative_weights="3350.8"
                     /alternative_weights="3368.9"
                     /alternative_weights="3386.9"
                     /alternative_weights="3404.9"
                     /alternative_weights="3422.9"
                     /alternative_weights="3440.9"
                     /alternative_weights="3459.0"
                     /alternative_weights="3477.0"
     gene            complement(13270..16356)
                     /locus_tag="GSN02_RS17440"
                     /old_locus_tag="GSN02_17445"
     CDS             complement(13270..16356)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03897.1"
                     /locus_tag="GSN02_RS17440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17445"
                     /product="type 2 lanthipeptide synthetase LanM family
                     protein"
                     /protein_id="WP_101501473.1"
                     /sec_met_domain="DUF4135 (E-value: 1.1e-96, bitscore:
                     322.2, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 2.1e-66, bitscore:
                     222.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTNKYNLQYWMKMFPEVNDKDELQKIFLNVSGKTIHSLIRDDTN
                     IEQNTNIIDIDRVLDHKKSDFLVRNSEEFLEHNPFFHFFSPFLSCKIEEFIVKVRIEDA
                     VDNEDEFVKKVIKHILDLMFEKAFRVLVLEVNIARLEGKLEGTTPEERLNHFLAVSLND
                     ESFLKSVYKEYEVLTSLLCVTIDDYFTYVMEIIKNTKREISSLNSKFNSDNDLGAITNI
                     TTGLGDTHQKGKSVSTIYFKSGKKIIYKPRDLTLEQGFQEVLYWLDGKNIPGILNFKRV
                     QIHTVNDSGWMEHIDYKSCFNKNEANDFYTRSGNLLCLLYLLNAVDFHHENLIAHGSFP
                     VLVDLESLFHARLKVDQIDKKSAFVTATELVDNSVQSISLLPTKISKRVGDKDISLDIG
                     GLGAYKEQLSPHKSLVIENAGTDTIKILRKNTFIKPQLNNPSIKTGSYLYSENYTGQIK
                     DGFESLYSWVMLNKDEFWDKISQTFKETNSRFIFRPTYLYTQLLRISSHPDFMRDTYRR
                     KIILHRIGIDYIQEYKDILNSEYKDLLTGDVPFFRSSIEHEHLIDSRGGKIHNILEEPP
                     IKTVKQKIFNLSKEDLKRQIDFIEMSYISNEKRLKEVTDIKFSKAANLNKIKSENWIDE
                     ATQIGEFIVENSVCGINKKQKDRMWIGPSLEGIEEDIWNANVLGFDIYNGNSGIALFLG
                     YLGEILNRQDFKQAAIETMRPIQKFISEIKEDHPYLIGAFQGISGYFYTLNKLSNLFED
                     SELRKTTLENISVLSKLGKFDKVYDLIGGSLGSLAVMLSIIPNITEENNKKEILKISHI
                     HCDHILSVAKNFEEQISWPGKFSAAYSGFSHGNSGFIAYLYKFFKLTNDEQLLEVIQRA
                     LRFERRLYSEDHNNWYTTENKDKLANGWCHGAPGILLSKLILKDNGFEDEYIEKEISTA
                     IDSSIHNGIGNNPTYCHGDLGVLSILNYASDLTNNINLKNRCLRTYQDLFENVLAMKWR
                     KRDLVCTRSYSLMIGLSGIGYSMIKNYAPEIVPNFLWLE"
     gene            complement(16428..16658)
                     /locus_tag="GSN02_RS17445"
                     /old_locus_tag="GSN02_17450"
     CDS             complement(16428..16658)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mature_ha"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_000884148.1"
                     /locus_tag="GSN02_RS17445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17450"
                     /product="plantaricin C family lantibiotic"
                     /protein_id="WP_101501474.1"
                     /sec_met_domain="mature_ha (E-value: 1.7e-06, bitscore:
                     25.5, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGAFNTWNT
                     TTTSVGTILVSEVFGNKGKVCTGTKECQGTC"
     CDS_motif       complement(16542..16658)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGA"
                     /locus_tag="GSN02_RS17445_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16428..16541)
                     /prepeptide="core"
                     /locus_tag="GSN02_RS17445_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-3.20"
                     /molecular_weight="3715.1"
                     /monoisotopic_mass="3712.9"
                     /core_sequence="FNTWNTTTTSVGTILVSEVFGNKGKVCTGTKECQGTC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKKTKILKTPELKVTKDLNLIDPCGDVLEEIKEHEVSGA"
                     /leader_location="[16541:16658](-)"
                     /alternative_weights="3733.2"
                     /alternative_weights="3751.2"
                     /alternative_weights="3769.2"
                     /alternative_weights="3787.2"
                     /alternative_weights="3805.2"
                     /alternative_weights="3823.3"
                     /alternative_weights="3841.3"
                     /alternative_weights="3859.3"
     misc_feature    16808..16821
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 22.67"
                     /tool="antismash"
     misc_feature    complement(16899..16911)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 20.68"
                     /tool="antismash"
     misc_feature    17168..17181
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 18.59"
                     /tool="antismash"
     gene            complement(17248..17822)
                     /locus_tag="GSN02_RS21300"
                     /pseudo=""
     CDS             complement(17248..17822)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001994360.1"
                     /locus_tag="GSN02_RS21300"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="DJ-1/PfpI family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAELNMGSFKKDAASLKVMTIG"
     misc_feature    17807..17821
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 18.09"
                     /tool="antismash"
     gene            complement(18016..19308)
                     /gene="eno"
                     /locus_tag="GSN02_RS17450"
                     /old_locus_tag="GSN02_17455"
     CDS             complement(18016..19308)
                     /EC_number="4.2.1.11"
                     /GO_component="GO:0000015 - phosphopyruvate hydratase
                     complex [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004634 - phosphopyruvate hydratase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="eno"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391270.1"
                     /locus_tag="GSN02_RS17450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17455"
                     /product="phosphopyruvate hydratase"
                     /protein_id="WP_003228333.1"
                     /transl_table=11
                     /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTGE
                     YEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTENKG
                     KLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNVDIQ
                     EFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEALQTI
                     VEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEELVSKY
                     PIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGNSILIKV
                     NQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTGAPSRTDR
                     VAKYNQLLRIEDQLAETAQYHGINSFYNLNK"
     gene            complement(19338..20873)
                     /gene="gpmI"
                     /locus_tag="GSN02_RS17455"
                     /old_locus_tag="GSN02_17460"
     CDS             complement(19338..20873)
                     /EC_number="5.4.2.12"
                     /codon_start=1
                     /gene="gpmI"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391271.1"
                     /locus_tag="GSN02_RS17455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17460"
                     /product="2,3-bisphosphoglycerate-independent
                     phosphoglycerate mutase"
                     /protein_id="WP_003228330.1"
                     /transl_table=11
                     /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQTL
                     TASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAISNA
                     KENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTAKTY
                     INQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALDVVDD
                     SYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKDFRDFD
                     RGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAETEKYPHV
                     TFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKHDAIILNF
                     ANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADILITESGEP
                     HTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSLIQK"
     gene            complement(20866..21627)
                     /gene="tpiA"
                     /locus_tag="GSN02_RS17460"
                     /old_locus_tag="GSN02_17465"
     CDS             complement(20866..21627)
                     /EC_number="5.3.1.1"
                     /GO_function="GO:0004807 - triose-phosphate isomerase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="tpiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391272.1"
                     /locus_tag="GSN02_RS17460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17465"
                     /product="triose-phosphate isomerase"
                     /protein_id="WP_003243394.1"
                     /transl_table=11
                     /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPAL
                     FLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMFAE
                     TDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVAASV
                     IAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPANIKEY
                     MAESDIDGALVGGASLEPQSFVQLLEEGQYE"
     gene            complement(21658..22842)
                     /gene="pgk"
                     /locus_tag="GSN02_RS17465"
                     /old_locus_tag="GSN02_17470"
     CDS             complement(21658..22842)
                     /EC_number="2.7.2.3"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004618 - phosphoglycerate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006096 - glycolytic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pgk"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391273.1"
                     /locus_tag="GSN02_RS17465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17470"
                     /product="phosphoglycerate kinase"
                     /protein_id="WP_003243051.1"
                     /transl_table=11
                     /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTIK
                     HLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQIS
                     EMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIAEHL
                     PAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIGGGLA
                     YTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDANVKIV
                     PISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAVAEALAE
                     AKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALNDK"
     misc_feature    complement(23082..23091)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.98"
                     /tool="antismash"
     gene            complement(23159..24166)
                     /gene="gap"
                     /locus_tag="GSN02_RS17470"
                     /old_locus_tag="GSN02_17475"
     CDS             complement(23159..24166)
                     /GO_function="GO:0016620 - oxidoreductase activity, acting
                     on the aldehyde or oxo group of donors, NAD or NADP as
                     acceptor [Evidence IEA]"
                     /GO_function="GO:0050661 - NADP binding [Evidence IEA]"
                     /GO_function="GO:0051287 - NAD binding [Evidence IEA]"
                     /GO_process="GO:0006006 - glucose metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="gap"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391274.1"
                     /locus_tag="GSN02_RS17470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17475"
                     /product="type I glyceraldehyde-3-phosphate dehydrogenase"
                     /protein_id="WP_003219957.1"
                     /transl_table=11
                     /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHLL
                     QYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTKRA
                     DAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPFAKV
                     LNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSLVLPE
                     LKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYSEEPLV
                     SGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKGL"
     gene            complement(24213..25235)
                     /gene="cggR"
                     /locus_tag="GSN02_RS17475"
                     /old_locus_tag="GSN02_17480"
     CDS             complement(24213..25235)
                     /codon_start=1
                     /gene="cggR"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:NP_391275.1"
                     /locus_tag="GSN02_RS17475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="GSN02_17480"
                     /product="gapA transcriptional regulator CggR"
                     /protein_id="WP_017695173.1"
                     /transl_table=11
                     /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASLE
                     ISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLKER
                     LNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMMTPD
                     SKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSIIEEP
                     SVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFNADGEV
                     VHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAKKLLRDE
                     "
     misc_feature    25330..25343
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.01"
                     /tool="antismash"
ORIGIN
        1 ccgtcaccgg cgttctgttc atcatttgct ctacccgctc gatatccggt cttgactgaa
       61 tcaggcgctc tttcccgata aattcttcaa caaactcatt tgccgggttt cgaagaatct
      121 catcaggtgt gccgacttga acgatttctc ccgcttttaa tatcacaatc ctgtcagcaa
      181 gcttaatcgc ttcatccata tcgtgggtta caaacacaat cgttttgttt aaggttctct
      241 gcagtttttt gaattcttcc tgaagggaat cacgcgtaat cggatcaagc gctccgaacg
      301 gttcatccat taaaatgaga gggggttccg ctgccagggc gcgcagcacg ccgattctct
      361 gctgctgtcc gccgctgagc tcatgcggat aacggtctaa atactccggg cccatatcca
      421 caagctttaa cagctcgcgc gcccgttctt tccgtttttc ctcaggccat ttcagcagct
      481 ttggtacgag tgagatgttc tgctggatgg tcatatgggg gaacaaacca atctgctgaa
      541 tcacatagcc gatttttctc ctcagctcaa ccgggtcctg ttccataata ttttctccgt
      601 cgataaagat ccttccagac gatggttcta tcagtctgtt gatcatcttc atcgttgtcg
      661 tttttccgca gccgctcggg ccgataaaac agataaattc acctttggca atatctaaat
      721 caatgctgtt cacagctttt ttgccgcctt tatatatttt tgacacttgt tccaatttca
      781 gcaatccgtg cacctccgca ggtttccttt aaattttctg aaaagtataa tccttattat
      841 agtttgaact ttgtaaaata aaaagtttac aatgtgttga aattatatgt tatttataga
      901 ttatttattg ttatgaccga gacggaaagg gtgttcttac aattacgccg gatacctccc
      961 acttcctctg cattcagcta ttttcaacac caggaagaaa tatgatatat tgacaccatc
     1021 aattgccatt tgaagggatg atcagctgtg aaaaaaaccg ctctcgacat cattgaacat
     1081 gctgaagagc atctcattga gaaaattgcc gagaatatgc atacgtttgg aatgccttca
     1141 actgtcggac gtgtgctcgg aattatttat atgaatcgaa aaccaatgac cttaagcgag
     1201 ctctctgagg caacgggcat gagcaaaaca cggatgagcc aggttgtccg ggaaatgatc
     1261 gatgccaata tcgccgaaaa ggtgtttgaa aaaggcgtac gaaaagacct ttatgacgtc
     1321 gagcaggatt attatcaaac cttcatttct ttatttgcgg cgaattggac aaaggtcgtg
     1381 agcaaaaaca aagtgctgta taaaaaatta aaccgggagc tgagtgatct tttacaaagg
     1441 gacgggctta ccccggaagc ggaagagaaa gtcaatcagc tgctgaatga attaaaagaa
     1501 tggcttcatt actatgattg gctaagcagg ttgattgaat tttttgagag tgaggaagtc
     1561 tttcggtatg tgccgaaaac aaaagaaagc agctctctaa aataagagag ctgctttttg
     1621 catcatgagg ttaagaccgg aaacatgcct ttcagcccgg caccaatcat cccgaccgca
     1681 accacggcta agattaatcc catcagtctg gtaatcacat tcatctcggt ttttccgagt
     1741 ttgctgctga taaaagcaga atagtggaaa aagagaaagg tcagggcaat aacggcggct
     1801 atgccgatca tgacagccgc ataatgacca atgccgctat gaccggcgga aaggctcatc
     1861 actgttgcaa tcgttccggg cccagcaata atcggaatgg ataaaggtgt gactgatata
     1921 tccgcttttt ccttgctttc cttatgttca tcatggtgaa gagattgcac gtgtgattct
     1981 ttcgcattca atagattata ggcaatgccg aaaatgaata tgccgcccgc cactcggagc
     2041 gcgtgaatgt tgatatcaaa cagtttaaag ataagatggc cgaaaaccaa aaaagccgcg
     2101 agaataaaaa aggataaaat agctgccttc cgggcaatcg cttttctttc cgctgcagta
     2161 tagccttctg tcagcgtcag aaatatcggt acgtttccga ttggattcga tactgcgaat
     2221 aaagaaatga agacgtgaac gatgaatgag aacatcatat acctccttgt tgatagtctc
     2281 tgcacaggaa atagaatgat tctccaccct tttacccgga ggcgatttcc cggtaaacct
     2341 ttatagcctg tcagaaacgc gccatgctac aatgaagtga caaattgaat aggaaggacg
     2401 tatgcagatg ttcaaaaaaa ttgcggcaga tgccttgggc ttatctgata tcggaaaaat
     2461 tatcgaacct caggactatg acaaaacaga cgcagatgat tatgtcatgc atgaagataa
     2521 tgagaaaatt tatttcttga ttaaaacaaa agcagacgag tattgcttta cgaacctggc
     2581 cctgatccat gtagacggcg aacgcgccac ttcctcgaaa cgaacgttga aacgctatcc
     2641 ttattcgcaa tataaaatct ctgacgtttt tcttgaaact gccggaaaag tggatttgga
     2701 tgttgaaatt aagttcaagc tgggcggaga acaattcgac attgatgtcc acaaagatca
     2761 gattgaaaaa ttaaaagacc tttataaagc tcttctccgc atcgctgaaa caacctatga
     2821 aaatgacatt ttaatcaatc aagcggagca aagcttagat aaagcagtga cgattcttca
     2881 ccatacccgc cctgagcacg tcaatattga aacgcaatat aaagaactga ccgaattcgg
     2941 attcacttgg ctgacatccg ttcgctcgca gtatcatatc aaggattttg gggatgtatt
     3001 tgagaaatat atgaataact agataaaaaa gacacagctg ctatcgggct cgtgtctttt
     3061 ttttgtatga atattgatta ctttacaact tttttctttt ataataaaac tattagtcta
     3121 ttttccctat attacaggta aaggagttat tttatgtatt gtcctcaatg cggccatcaa
     3181 acagatggcg gaaatttttg tgagaaatgc ggatcaccgc tccccggtca atcaggccac
     3241 cagcatccag ctcaaactgg agccgctgca aagcaagcag caaaacagtt cggttcattt
     3301 gtcttatccg tcctgaaacg cccttatcag gaatgtaaag caacaggcgg agagcagttg
     3361 atcagcgcgg tgattacgct ggttcttttc agtttgctga cccctttgat gttttatatt
     3421 cttttttcag acggtcccgg aagcgtaagc tttacagcaa tctttttaga gccaaccatt
     3481 tattttattt tatttctatt tggcctgcat gcatgcatct ttttcgccct gaaaatcgcg
     3541 ggaaaccaag tatctttcaa ggattcattc tcaagattcg gagcgtttct cataccgttt
     3601 acggctattt tgattcttgc ccttttcttc tttttattac atacagacat ttgctttacc
     3661 atattagccg ttggtttaat cggtgcattc ttcgccattc ctcctgcgat gctgggcagt
     3721 taccagcatt catataaagg gaaaattgat gtcatttact caacgattgt gatttatctg
     3781 atcatctgcg ttacatttca gcttattatc gaacactatg tcaaagaaat tttccgttat
     3841 atgctctttt aaaaacaacc ccatcacctg ctggtgatgg ggttgtttta ttgaatagac
     3901 gttaagtaaa ttcttccgtt cttcactacg ccggtgtagg tccagttata tgttctgagc
     3961 tttggactgc cgcctgattt tgtgatatag aattcttcat acgtcttaat cgtgatagcc
     4021 gacccatttt ggctccagct tttcacttca tagttattaa agtcttctgt tgtcccctct
     4081 ttatttaatt tcgacacgag atgctgctgg tcggaataaa gggaactgcc tttttcaagg
     4141 ctgtcttcca tcagtgagaa attattttga ttcacggcat ctgcctgact ttgcagataa
     4201 ctgcccataa ataatgtcac ttgttcatct gtaacatcgc cgcttgcaga gctttcactg
     4261 cctttgtttt tcgagccagc ccaggcggaa gtgtatgtct ctggtttatc atttttgatt
     4321 ttctttatat ttgtgcctgc agattggaat gttgattctg catcttcgaa aatccacttt
     4381 ttctgttttt tatcatatga aagaagatat tcataactcg gactgtcgtc agtcatttca
     4441 gattttgtat agtcgttata cgaagaagac tggtgaagtt cttttcctgt tacagatacc
     4501 tgccacgttc cgtcgttttt ctgagagagg gcaaatgtgt ccaggtcaaa atcagtttcc
     4561 aagtatctat cttttaagta tgaatccgcg cttttcatag aatcaacggt gtccttcgtc
     4621 tctgccttcc aattggcact tgcctctgtc atctgggctg tattcccatc agatagagct
     4681 ttggagtatt gttttgttgt tttgacaatt gtgttcataa tctgttcctg tgtatcttga
     4741 tcaggaatta acgttaactc catttcttta tcatcgatcg gaacgccggc agtttttgtt
     4801 tttccccacg gaaattctgc ctcgactgaa gctgtcattg atccatctgt cagcagcgga
     4861 ccgtatgtta cggatttgaa tgggtcttta tgaatcgact tgccgttaat cagcaaatct
     4921 cccttcccgc tcttgatgtc atccgctaag ctgaatgtca catcgtctgc ttccaatgag
     4981 agatcaacac gaaagctgtt atcgccaacc gcctgaatgt cttccttttt cacaaggtca
     5041 acgacatcgt ttttcagttt ggctgagact gtatattcgc cgggaatgta cggaccgagg
     5101 gtttgtgctt gatctgcttt ctttacagat ccggcttcct ctttattgac atataaatcg
     5161 gtatttttat aattgctggt cacttcaaaa taaacaggtg ctacctttaa gtcgtaatgg
     5221 tcaaatacca gcaggctttt tccgtctttt tctgcgtata cgatatcctt ctgggctgtt
     5281 tcctcacgga gcgatgcaaa aagttcatct tttttgtctg gatgatcctt caaatatgta
     5341 agaaacggtt ttacactatt tttagtgagt ttaagattgt catttaccgg tgtaagcaga
     5401 gtcgcgattt ggtcctgatc cccatcattt acggcctgtt caaacttgtc tactaaccta
     5461 tcctttgaag taaaatacgc tccggtttta tatgcggcga ataatataac gcacgccgcg
     5521 gcaatgctgc tccataaaat gatggttttc ttagggatcg gttttcgcgg agcctgcctc
     5581 gtttctgcag tgctagctgt ttcttgattt gcctgtttgc taccccctcc gatcggggtg
     5641 ccgcattgtt tacaaaactt ggctccttca ttattctggg agccgcaatt cttacaaaaa
     5701 aacatgactt tcctcctatt ctactaattt gataacattt actgcttttc atattttata
     5761 ataaaacaga atgaaattgg gaacgaatga aaaaattaaa tgtctatcag actaaaaagg
     5821 tggaatgaat atgcaaaagc tcaggattga attaggagaa gaaacaaatg acgaactata
     5881 tgatctattg ctgctcgccg atccatcgaa agacattgta gatgaatatc ttgagagggg
     5941 agaatgttac acagcttggg ccggtgatga gcttgcaggt gtttatgtat tgctaaaaac
     6001 aaggccgcaa acagttgaaa ttgtaaatat tgcggtaaaa gaatctcttc agaagaaagg
     6061 ctttggcaaa cagcttgtac ttgacgccat cgaaaaagcg aaggagctgg gggcggacac
     6121 gattgaaatc ggcacgggga attcgagcat tcatcagctt tccctctatc aaaaatgcgg
     6181 attccgcatt caggcgatcg accacgattt ctttgtcaga cattatgatg aggacatttt
     6241 tgaaaacggg attcaatgcc gcgatatggt aaggctttat ttggatcttt aataaaagag
     6301 ctgccgtggg ctaccccgtt tttgagacag ggattaaaac accttttaaa cagccaattg
     6361 ccgacagttt atcggtgatt ggctgtttag tttcgtttga atacggaata ttattataat
     6421 aaatgtagtc tttgacattg cgttctacaa tgatggtcga ggttcgttca atgctgttaa
     6481 ggtataacgt tttagatttt agtgaggaat gaaacgattc gatgaaagca ttatcatcgg
     6541 gcgtttcttt gcgggacatg ctcatagtaa ttcctttttt taacagctga aacacataag
     6601 atgtattaca gaaccttgat catttgtaac acgtagctct caggcatcgt tggcagctga
     6661 tctagtgtgt gtaagacaaa gtctgtgtcc tgtttatctc caatcgcaaa ggcatatggc
     6721 tgcccatttt tcttgctttt cttgatctta atccggcatc gccactgaat ttctaaataa
     6781 tacgctaaac catttaatgg ttaatgctca tttcctattt ttaataggtc agtgattttc
     6841 cgagatccat atcgatactt gtgctttagg cacaattcgc taattgtttc tctaaatgcc
     6901 gtttggagtg atctttcttc agattctttt ccaacgataa taagacgctc gtgagatacc
     6961 taaatgaata cagatatcct gcacgctcat tgtgctgtgc aattcttcta caagttcgac
     7021 tgacgtttgg ctatcaactt ccttttttta attcattgtt cattctgttg cctcagatat
     7081 ctattctctg cctgcagttt ctctaatttg acgcatactt gacctttttt gtaagtgtat
     7141 tgctttctaa cagactgttc gaacgggtgt gtatctccaa atcatctaac ccatgtctaa
     7201 acctgtggct tattcttgat attaaatttc tgcatgatct ctttcataag cacgcccgcc
     7261 aatctcattt ctacagcttt ctgttacact tcaactagat aactcactct tgtcaccata
     7321 gaaaaaacac ctccaagtct aatgtcggat aacaatcatc cgtatcaaac tggaagatgt
     7381 ttttatttgt ctcattttat aggtcagtct cccttgtttt tttctaaaag acataaaatt
     7441 gcaatgaata atcttttttt attggtagga acatcaaata atagattgat acttattaat
     7501 ccataaaatt tctgttcttt ataccattct aacattaaca attattaaaa taaaattgaa
     7561 ttttaacgtt aattcctcag tttctgtttc ctactaaaag agttaatatc ttatcattaa
     7621 tcttgatgtt aagattacat tatacttatt ttttattatt tttgtatcta gcataaaaat
     7681 aaaagtcaat taacgatcca atcaatattc ctagggaaag accgtacggt aaaatatcga
     7741 aaacaactcc cataaaaaga cctaaacaaa aacctattac tagaaatacc gctccatctc
     7801 ctttatagtt tttcaaatta gacaactcct taatagtaat tgatacgcta tgttttttat
     7861 cttttcattt gtgaacgata tagattacta tatacccctt ctaaagcaat cagttcttca
     7921 tgtttgccaa tctccaccac ttcaccttta tctaggacaa ttataaaatc tgaatccata
     7981 attgttgaca atctatgcgc gataaccact cttgtgcatc ccatttcact taaatattta
     8041 gaaatcaatg tttcattcac caaatctaat gaacttgtag cctcatctaa aattaaaatt
     8101 ttagggtcat ttaaaagtgc tctggctagt acgatccttt gtcgctggcc acctgataaa
     8161 ttcataccca tttctgaaat aggtgtatta tatttcattg gcatgctttc aatttcttta
     8221 tcaatttgtg ctgctttcgc tacttttctc actttttcta tactagtatt tttattattc
     8281 aatgtaatat ttttcagtat agaactatta aacaaggtaa tgtcctgggg tacaattccc
     8341 atttgtttgt acaactgttt tttatctaat ttttcaagag ggatactatc aaaacaaatt
     8401 tgtccttcag tcggatcata aagccccatt attaacttac taagagtact tttacctgaa
     8461 ccagatgaac ctactatagc aattttctgt ccttctctta tttccaaaga aatattctta
     8521 agcacctttg gagaatgttt agtataagaa aaagaaacat tttcaagctt tacatttcct
     8581 cttaatttaa ggtttactgc attttcaaaa tttttttcac attcagtctc tgtaatatct
     8641 ttaactcttt ctaagtaaga agtagctaag ataaactgag tataagtacc aaataaagaa
     8701 gttgttaatc cgaaaaaagt aacagataaa gaatgatatg cgataacctc tcccatggta
     8761 aatttattat caaaaaataa tagcagttct aatattaaaa taaccaaggg agcaattgtt
     8821 tgaaaaacct gagttactgt attaactata ttttgtaaaa ttgatctttt tttgaatcgc
     8881 tttattacat cattaaaact gttattccaa gttgagaaaa tttcattttc cattcccgaa
     8941 attttaatgg ctgcgataga aaaaatagac tcgatttgaa ttgcttgaga tttactttgc
     9001 tcagctactt catcatcgat ggcctgtgcg acagcaggtc tagtcaaaaa catgaatatc
     9061 gtgttaattg caaatattaa tattgttatc aaggttaatg gtatagattt aaagaacata
     9121 tacgctaaaa taaaaactac cgctcctaaa tcaattaggc cagaaattag ttgagtcgat
     9181 aaaagctctc tgaatccatt catgctattt aacctaaata acaagtcacc aggtgatcta
     9241 agatcaaaga atttaaaagg aagttttaga agatgagcaa atgtgtcaac aacaagattt
     9301 ttactaagga atatattgag gcttatcatt ttgagccctc taaataaaac aaacattcca
     9361 tacaatattg atattaaaaa tgttatccaa acaatattac ttattgaatt taagttatta
     9421 tgctcaatac ttgtatctat aagcttctgt accaaaatag gtacatacag cgtcaataaa
     9481 taacttatta gcgataaaaa tactataata gaaaatagca atttatagtt tgtaatattt
     9541 ttcaatacac caaaccatac atttttatct tttcttttat taggcgtgaa attttctgaa
     9601 ggaactgcat atagaatgta ggacgagaaa cctttcctaa actcttcttc ggttaatttt
     9661 cttcgtccat tagccggatc tataatataa taaaaatttt tttttgtttt ttcaacgact
     9721 ataaaatgtt cattattcca ataagcaata aaaggaacat taattttttt taatcctgga
     9781 atagtggatt tgtatatatc cgccttaaat cctttatgaa ctaataagtt ttttaactgc
     9841 ttaatagtaa gtccgtctct tccagcctct aaaaatgatc ttaactcaaa aagagtttcg
     9901 ttactgttat aaaaacggat caacatagca caacagcaaa gtccacattc agtttgttgc
     9961 aattgtttta cgataggtat tctctttttt ttctttacta tcattcattg taactcctta
    10021 cttccattgc taacaatgaa ggatttacag gattatgtaa tcttaataag ctgtagccta
    10081 cgcctccaag tccgagcata aacgtattta aatcaaaatg atcctgtaaa cctggaataa
    10141 aacctttatc tcttatataa ttaattgcgt tttgagcttc tttaaatgct acttcctgaa
    10201 gatctatgtc attgagaaat tcacttagtt tcaataatat atctatatta ccaaaactgc
    10261 catgacataa gctatgatcg gttgtttttt taaatccatc ggaaaggagc ttgcatatag
    10321 ctgaacttaa atctctatca acttctttat caatctcttt atcaactacg ttctctttat
    10381 tcttcaacag gtcttttaaa aaagctcttg atagagctat acctcccgca ccatgacacc
    10441 aatatactgg atcagagttt ccctctccca ctctcaaatc tttccaattt gaggtgtgca
    10501 aatcaaaaaa cttattttct attttcaata actcttttcc caaagtcgtg tatttttcct
    10561 ctttagtaat atgaccaaga taacaaagag cccacgtaaa accagaatac ccatgtgaaa
    10621 gccctgttag ataattatgt ttatcattct ctaagcattg atataaagta ttacctagtt
    10681 tacaacacac ggagtttaaa atatctaatt tagtttcctt atataggttt aataaaaaaa
    10741 caataagact agatactccc cctacaatat ccaatgctat atctcctgaa atattcattt
    10801 catttatctt cttaatatat tttttaaatt tttcatagta tttataatca tttgtatggg
    10861 tgtataagtg gtaatatata taggataagg aacctattcc tgtaaatagt gataaccggt
    10921 catccatctt atcatcactc aaaaaaagtt cttcaatgcc tctcatccct gcaagggcta
    10981 aatcaaagta ctctttttta ccattttctt ttccaagtaa agctaagaat aatattactc
    11041 ctccaccttc atataagtca aagttcaatg gacccaattt tactttatta ttctcagata
    11101 ttataggtgc tacccaagta catttgcttc tatcattatt ccatattgct gtttctaaaa
    11161 ataagtctcc tatttctgtt gcacactcta aataattttt attattattt ccaaataatt
    11221 taggacgata tttcttattg tgtttgtttg tttttttcca actgtctttt atagttgtag
    11281 taagtgacat tcgaatataa tattgctgtt tttttaaact tgccttactt atacttttaa
    11341 ttttgtttaa tacaacatct agtagacttt ctctaaaaaa atttactata cttgtacttt
    11401 tattacaaat caaatccaaa gaattataca ttgttgaaaa atacggaaca tcattacaca
    11461 ttaaagattc caactcatat aaattcttct tgctaaattt atctgttact ccttccgcaa
    11521 tatttatttt tttaaataac ttctttcttt cctcaaaact agataaataa tttggatgag
    11581 tggaagcttc taaaaacctt gcatatatac tggtagctct taaaacttgc cttacttcca
    11641 ggttgctgct tcctactttt ttcaccaaat catgaaaacc actaatattt tctaaaacaa
    11701 aattataaca atctgtaaaa ccttttaata tttcttcaat ataattttta gggtctgcag
    11761 ctttcccatt atatgtagct ctgttttgag tactgttcat tattactgat tttttagtta
    11821 actgaatttc atcagttcct tcgaaatcta taatatacga tttccatatt tctgatgttt
    11881 gattttcatc atttgatatt ccgccaaggt caaaatcaaa tatagaagtt tgtaaattta
    11941 atgggagaag catagtgcca agaactgagt aattaatatc ctcatgaaag ttatcaatta
    12001 aattattatt tcttggttta tatatagaat tattttttat cagagtctcc aaatcaataa
    12061 caacaggata ttcgccatgt gcaattaagt tttcatgatg caaatcatcg catcctataa
    12121 tatgaaaaat agataaactt acacctactc tataaaaata gaagttaagt ttttcggaag
    12181 tctcacattc tttataatca ataaactctt gatagccata gtctttataa ttaagcgttc
    12241 taattttata aatttttttt agaattttat ctgaattatt aacatagtca actatactat
    12301 taaataagat atcaggagat aaactatgcg gtttatatac aattttccct tgatttgttt
    12361 caattattaa gacatttttc cctccattat gagtgtctcc gctgctaaaa taaatattgg
    12421 agacttcatc aaattcaatt cttaattctc tataaatgtc ttggcgattt tttcttaaat
    12481 tctctagaac ttctttcaag tacaagattt tattagatat tctactagaa attaaatagg
    12541 ttaaaacagg atacttattc aaaatttcag caacatattc gctcttaaaa attagattat
    12601 tataattctt atagcgtaac tttgaatctt ttccttctaa taaacctttt tcttttctat
    12661 cattaatatc cacgattaaa gttcttatac ataactgaat taattcctgg ctaaaagcct
    12721 ctaacgcact acttataatt ttttgtttgt taagttttaa attattttcc ttacttgcgt
    12781 tttctaaagt attaaataat ctttgttgat aaaaatctaa aaagaatgta taaaagttgc
    12841 caaagtaatc tttgtttttt attcttaatt tttctacttc atttgtcggc gaactgaaat
    12901 taattacagc atccctgatg aaattattgt tttcatagct aatatccatt tataacctct
    12961 ccaaaagaat taatagagaa ttgtttggta aaacaattct ctattaacac attgtgttta
    13021 tttgttacac agatttgtac acgctgatgt tggacatgat gctgcactta aagtaactgt
    13081 aaaagtcgtt ccagtaagtg cagttataat ggctgttacc ggagtacctc ctccagtagc
    13141 attttcacca ttagctaacg atataagttc atcttcttca ataaaacctg aagcattttt
    13201 gaccatatct ttcttcataa tttttctcac ctcctttcaa gtatgacttt gaataagagt
    13261 gtatagaact tattctagcc ataaaaaatt aggaacaatt tccggagcat aattcttgat
    13321 cattgagtaa cctattcctg ataatccgat cattaaacta tatgatctag tacagactaa
    13381 gtctctcttt ctccatttca tggccaaaac attttcaaat aagtcttgat aagttcttaa
    13441 acatctattc ttcaaattaa tattgttagt taaatcagaa gcataattta atatagaaag
    13501 cacacctaaa tctccatgac aatatgtagg gttattgcca atgccattat gaatagaaga
    13561 atctattgca gtcgatattt ctttttcaat gtactcgtct tcaaaaccat tatcttttaa
    13621 aatcaattta cttaaaagta tacctggagc tccgtgacac catccattag ctaacttatc
    13681 tttattttct gtggtatacc aattattgtg gtcttcagag tacaatctcc tttcaaatct
    13741 taaggccctt tgaatgactt ccaataattg ttcatcattt gttaacttaa aaaatttata
    13801 taagtatgcg ataaaaccag aattaccatg tgaaaaccca gaatatgctg ctgaaaattt
    13861 tcctggccaa gatatttgct cctcaaaatt tttcgctaca cttaaaatat gatcacagtg
    13921 gatatgtgag atctttaaaa tttccttttt gttattctct tcagtaatat ttggtattat
    13981 ggaaagcata actgctaaac tacctaaaga acctcctatt aaatcgtata ctttatcgaa
    14041 tttacctaac ttcgataaaa cactgatatt ttcaagtgtg gtcttcctta attctgaatc
    14101 ttcgaataaa ttagataact tgtttaatgt ataaaagtat cctgaaatac cttggaatgc
    14161 acctattaaa tatgggtgat cttcttttat ttcagagata aacttctgta ttggtctcat
    14221 agtttcaata gctgcttgtt taaaatcttg tctgttgagg atttcgccca agtaccctaa
    14281 aaatagagca atccctgaat taccattata tatatcgaat cccaatacat ttgcattcca
    14341 aatgtcttcc tcaataccct caagactagg acctatccac attctatctt tttgtttttt
    14401 atttatacca catacactgt tttcaactat aaattcgcct atctgggttg cttcatctat
    14461 ccaattttct gacttaattt tatttaagtt tgcagcttta gagaatttta tatcagtaac
    14521 ttcttttaat cttttttcat tactaatgta agacatttca ataaaatcaa tctgtctttt
    14581 caaatcttct ttcgatagat taaaaatctt ttgctttact gtttttattg gaggttcttc
    14641 cagaatattg tgaatttttc cccctctaga atctattaaa tgttcatgtt caatagagga
    14701 tctaaaaaat ggaacgtctc cagttaataa atctttatat tctgagttca atatatcttt
    14761 atactcttgt atataatcaa taccgattct atgtaaaata atcttacgtc tataggtatc
    14821 tctcataaaa tctggatgac ttgaaattct taaaagctga gtgtataagt aagtaggtct
    14881 gaagataaac ctgctatttg tttctttaaa agtttgagaa attttatccc agaattcatc
    14941 tttatttaac atcacccaac tatataaact ttcaaaacca tctttaattt gtcccgtata
    15001 attttctgaa tataagtagg accctgtttt aatggaaggg ttatttaatt gaggtttaat
    15061 gaaagtattt tttcttaaaa ttttaatagt atctgttcct gcattttcaa ttactaatga
    15121 tttatgagga gagagttgtt ccttataggc acctaatccc cctatatcta gacttatgtc
    15181 tttgtctcct actctcttag aaatttttgt aggcaataaa cttattgact gtacagagtt
    15241 atcaactaat tcagttgctg taacaaaagc tgacttttta tcaatttggt caacctttag
    15301 tcttgcatga aataatgatt ctaggtcaac taatactggg aaagaaccat gggctattaa
    15361 attttcatga tgaaaatcta ctgcatttag aagatacagt aaacaaagaa gattacctga
    15421 acgagtataa aaatcatttg cttcattttt attaaaacaa cttttataat ctatgtgctc
    15481 catccaaccc gaatcattta ctgtatgtat ttgaactctt ttgaaattta aaattcccgg
    15541 tatgtttttc ccatccaacc aatataatac ttcctggaaa ccttgttcaa gcgttaaatc
    15601 tctaggttta taaattattt tcttaccact tttaaaatat attgttgaaa cagattttcc
    15661 tttttgatga gtatctccta gaccggtggt tatatttgtt attgcaccta aatcgttatc
    15721 agagttgaat ttagagttta atgaactaat ttctcgtttt gtgtttttta ttatttccat
    15781 tacatatgtg aaataatcat caatcgttac acataataaa cttgttaata cttcatattc
    15841 tttataaaca ctttttaaaa atgattcatc atttaaagat acagctaaaa aatgatttag
    15901 tctttcttcc ggagtagtcc cctctaactt cccctctaat cttgcaatat tcacttccaa
    15961 aacaagaacc ctaaaagctt tttcaaacat taaatccaat atatgtttaa ttaccttttt
    16021 cacaaattca tcctcattat ctactgcatc ttcaattctt acttttacta tgaattcttc
    16081 aattttgcag ctaagaaaag gagaaaaaaa atgaaaaaat ggattatgct ctaaaaattc
    16141 ttcagaattt ctcactaaaa aatcactttt tttatgatct aagactctat caatatctat
    16201 aatgtttgta ttttgctcaa tattagtatc gtctctaatt aatgaatgaa tcgtcttacc
    16261 agatacattt aaaaaaatct tttgcaattc atctttgtcg ttaacctcag gaaacatttt
    16321 catccaatat tggagattat atttgttagt tttcaaagtt aatgatccta ccttaatgat
    16381 tttttacaaa ataggcagtc aattccactg cctattttgt acttatttca gcaagtgcct
    16441 tgacattctt tagtacctgt acaaacctta cctttatttc caaaaacttc acttactaaa
    16501 atagtcccca cgctagtagt tgttgtattc caggtattga aagctcctga aacttcatgt
    16561 tctttaattt cttcaagaac atctccacat gggtctatca aatttaaatc ttttgtcact
    16621 ttcaattctg gtgttttcaa tatctttgtc ttcttcatac tatctacctc cttatttttt
    16681 actggataat gtttctatta acctgtccaa taaaaatcta ccatattttc ctatagaaaa
    16741 caatgggttt tatgtaattt tttatatttt tgaatacata agaatttctt gcatttcact
    16801 ttattttatt ttttaaaaaa gaactcttca gttttttgtg aatgtcactt ttaaatgctt
    16861 tagcaagaaa ccaaaacgat tttcaaatta ttatttcatt gcaaaacgta agccctactt
    16921 ttgcaagtaa aagaaccaac atacagttat gttacatact tttatttaaa gaagtaatta
    16981 ttttcctttg aagctataaa atcaaatagg aatataagta actatcattt tatacaacca
    17041 gctactacct taactattta taagtattat atgcagttaa ttctgagctg ccgtcgacca
    17101 ttgtttttta cccgtaggac ttagctaatt actctccgtc cctatctgag accgctgaat
    17161 tactgatata actatccgtg atcacaagat tgttcacttc tcgttttagg gaatactgga
    17221 gtgaataaac catgctttga caatcctcta aatactagtt atgatcatgg tcttacattt
    17281 attgattgag tttattaact taaagaagtg ttcgagttga tgggtcttat tgagttgata
    17341 ccatgaatcg aatgtataca tttcaaacac ggttaatttt ttcagtactt ccctctgagt
    17401 tcgagacagc tcacacttga tgcagtaacc agattcccac caaatacctc gggttccata
    17461 tcataaagtg gttctccttt atcatgtgga cagatcattt tcatatatgc cattattgct
    17521 tgtatgtttt cttgattcca agcatccgtt atttgctgaa cccacagtta cacgtaaatt
    17581 gtggcaacca tcacgcaaag ttttaaagct ttgctggcca ttttcaagga aactcttcac
    17641 cccaagtatt ccctccaagt aatattaata aatctgtact cttgagcatc cactcatcaa
    17701 gggagatatt cggttttata cgcagtgctc catcgtagtt atcattactt tattcatcct
    17761 attgtcatga cttttaaaga tgctgcatct tttttgaaac ttcccatgtt cagttcggcc
    17821 attaaatata tctaatctga tattgtagga aatgcgtaaa gataagctgg tttcgactgt
    17881 attcaaaaac aatgcaattg aaatctatac aattattata ctcaaaaacc ctgacactct
    17941 tgtcaggata aaagaaattc agctctttca cactaaaaag agcttggccg catctgcagc
    18001 caagctctaa tatgcttact tgtttaagtt gtagaaagag ttgataccgt ggtattgagc
    18061 agtttcagcc aactgatctt cgatgcgaag aagctggttg tatttcgcaa cacggtccgt
    18121 acgagacgga gcacctgttt tgatttgtcc tgcgtttgtt gccacagcga tgtcagcgat
    18181 tgtgctgtct tcagtttcac cagaacggtg agagataaca gctgtgtagc ctgcgcgttt
    18241 cgccatttcg atcgcatcga atgtttcagt caatgtaccg atttggttta ctttgatcag
    18301 gatagagttg cctacgccgt ttttaatacc ttcagaaagt tttttcgtgt ttgtaacgaa
    18361 gaggtcgtca ccaacaagct gaactttttt gccaagacgc tcagtaagaa gcttgtggcc
    18421 ttcccagtcg ttttcatcaa gtccgtcttc gatagagatg attgggtatt tagaaacaag
    18481 ctcttcatac cagtcaacca tttcagcaga tgttttcaca acgccttcgc cagacagatg
    18541 gtatttgccg tcttctttgt tgtagaactc agaagatgca gcatccatag caagtttaac
    18601 ttcttcgcca ggtttgaagc cggctttttc gattgcttca acgattgttt gaagcgcttc
    18661 ttcgttagaa ccaaggtttg gagcgaatcc gccttcgtca cctacagcag tgtttaagcc
    18721 ttttgcgctt aatactgatt tcaggctgtg gaagatttga gcgcccatgc gaagtgcttc
    18781 acggaagtta ggagcaccta caggcatgat catgaattct tgaatatcca cgttgttatc
    18841 agcatgctct ccgccgttta cgatgttcat catcggtaca ggaagcgttt ttgagttgaa
    18901 tcctccaagg tattggtaaa gaggaatctg taagaaatca gcagcagcac gcgcacaagc
    18961 catagatacg ccaaggattg cgttcgcacc aagtttgcct ttgttttcag taccgtcaag
    19021 ctcgattaaa agctgatcga ttgcgttttg ttcagttaca tcaaagccaa gaagctctgg
    19081 agcaatgatt tcgtttacgt tgttaacagc tgttaacacg ccttttccaa ggtaacggtc
    19141 tttgtcgccg tcacgaagct caaccgcttc gtattcacct gtagaagctc cgcttggcac
    19201 taatgcgcgg ccgaaagctc ctgtttctgt atatacttca acttcaactg ttgggttgcc
    19261 gcgggagtct aatacttcgc gtgcataaac atcaacaatg tatggcatga gttttgtctc
    19321 tccttttgat tttcaaatta tttttgaatt aaagatgttc ctgtcatttc tttcggtttt
    19381 tcaacaccaa gaaggtctaa taacgttggt gcaaggtcgc ctaggattcc gccttcacgc
    19441 agcgtaatgc cttctttcgt tacaatcaca gggactgggt ttgttgtatg cgcagtgtgc
    19501 ggttcgcctg attctgtaat cagaatgtca gcattaccgt gatcagcggt aatgatggca
    19561 tgtccgcctt tagcaagaat cgcgtcaacg acttcgccca agcattcgtc cactgcttca
    19621 attgctttaa ttgttggttc aaccattccg gagtggccga ccatatcagg gtttgcgaag
    19681 ttaagaatga tcgcgtcatg cttgtcagct tcaatttctt tgacaagcgc gtctttcact
    19741 tcataagcac tcatctcagg cttcaagtca tacgttgcaa ctttaggcga gttgatgaga
    19801 atacgctctt cacccgggaa ttcagcttca cggccgccgc tcataaagaa cgtgacgtgc
    19861 ggatactttt cagtttctgc aattcgaagc tgttttaatc cgtgctgaga taatacttct
    19921 ccgactgtgt tatcaagatt tatcggttta aacgctacat agccgtcaac tgtttcactg
    19981 aagtgagtca ggcagacgaa atacaggttc tttggataat tctcgccgcg gtcgaagtca
    20041 cggaagtctt tgtttgtgaa cgtgttggaa atctggatgg cgcggtccgg tctgaaatta
    20101 tagaaaatca cagaatcgcc gtcttggatt ttcgcaacag gctcaccgtt ttcttttgtg
    20161 atgacagatg gaatcacgaa ttcatcgtag ataccatttg catatgaatc atcaacaaca
    20221 tccagggcgc tgcggtaaga tgggccttcg ccgtacgcca ttgcgcggta cgctttttct
    20281 acacggtccc agcgtttgtc gcggtccata gagtagtaac gtccggaaat gctggcgatt
    20341 tcacctacac cgatttcctt gatttgatcg ttcaactggt tgatgtacgt tttcgctgtc
    20401 tgcggaccta catcacggcc gtcaaggaag ccatggatat aaacctttgt cagcccttct
    20461 tttttcgcaa gctttaacag tgcgaataaa tggttgatat ggctgtgcac gcctccgtca
    20521 gataaaagac cgaacaggtg caaggctttg ttgttttctt tcgcgttgct gatcgcgtca
    20581 aggaatgttt gattgcgttc gaactctcct tcgcgaatgg caacatttac gcgtgttaag
    20641 ctttggtaca caatacgtcc cgcaccgata tttaagtgac ctacttcgga gttccccatt
    20701 tgcccttcag gaagacctac agcctcgcct gaagcagtca atgtttgatg aggatactgg
    20761 ttccaatagc ggtcaaaatt cggttttttc gctaaagcga ctgcgttccc tactgtttcg
    20821 ttacgtaatc cgaacccatc aagaatgatg agtgcagctg gttttttact catattgacc
    20881 ttcctccaat aattgaacga atgactgtgg ctcaaggctc gcgccgccga ccaaagcacc
    20941 gtcaatatcg gactctgcca tatattcttt aatgtttgca ggctttacgc ttccgccata
    21001 ttggatgcga agcttgtctg cagcttcttg gctgaagctt tcagcgacgg ttttacggat
    21061 atgcgcacac acgtcattcg catctttcgc tgtagaagat ttgcctgttc cgattgccca
    21121 gattggctca tacgcaataa cagaagcagc aacttgttct tcagaaagac cagcaaggcc
    21181 ttttttcact tggtcagcaa caagatcatt tgttttgccg gcttcacgct cttcaagcgt
    21241 ttcacctaca cagatgatcg gcacaatgcc gtgtttgaaa gctgcgtgtg cttttttgtt
    21301 aactgtttca tcagtttcag cgaacatttc acggcgctca gagtggccga tgacgcagta
    21361 gtcaacgcca aggtctttca gagcaaccgg gctgatttcg cctgtgaacg cgccgctttc
    21421 ttcgaagtgc atgttttgag cgccgacttt taggtcagtg cctttcacag cagaagcaag
    21481 cttttctaag aaaagcgctg gcgcgcaaac aacagcttca gctttgtctg ctgctggaat
    21541 ggaagatttc acttcttcaa cgaagctgac agcttcgccg agtgttttgt tcattttcca
    21601 gttaccggcg ataattggtt ttctcatctg ttccacttcc ttatagcagt tttgagatta
    21661 tttatcgttc agtgcagcta cccctggaag ctctttgcct tccataaact caagggatgc
    21721 gccgccgcct gttgagatgt ggctcatttt gtcagcaagg ccgaattttt caaccgctgc
    21781 cgcagagtct cctccgccga tgacagagta tgtatctttc gcctctgcca atgcttccgc
    21841 aaccgctttt gttccttgag cgaacaagtc gatttcgaat acgcccattg gtccgttcca
    21901 cacgacaagt ttgctgtttt tgatgacgtc agcatacgtt tcgcgtgttt tcgtaccaat
    21961 gtcgattgct tctaaatcac tagggatttc agagatcggc acaattttca cgtttgcatc
    22021 gttagagaaa tcatctgcaa cgagtacatc ttcaggcatg tagaagttaa cgcctttttc
    22081 tttagcgcgg tccataaatg atttcgcaag ctcgatttta tcctcttcaa gaagagattt
    22141 accgacttca tagccaagcg cttttacgaa agtataagca agacctccgc cgatgatcag
    22201 gttgtctact ttatcaagaa gactctcgat tacaccgatt ttgtctttta ctttcgctcc
    22261 gccgatgatc gctgtgaacg ggcggtcagg attggaaacc gcttttccaa gtacatcaag
    22321 ctctttttcc attaagaaac ctgcaactgc tggcagatgc tcggcaattc cagctgtaga
    22381 tgcgtgagca cggtgggcag caccgaatgc gtcatttaca tatacatctg caagctcagc
    22441 aaatgctttt gcaagctcag ggtcattttt ctcttcacca ggatagaaac gtacgttttc
    22501 caatacaaga acgtctccgt ccttcatctc ggaaatttgt gcttttacag catcgccgta
    22561 tgcttcatcc gcttttttca cttctttgcc aagcagttcg ccgagacgtg cagcgacagg
    22621 agttaaacga agctcctcaa ccacttcgcc tttcgggcgg cctaagtggc tcgcaagaag
    22681 gacttttgcg ccttggtctg caaggtgttt gattgttgga agcgcagcac ggatacgtgt
    22741 atcgtctgtt acttccccgt ctttcattgg aacgttaaag tcaacgcggc agaatacaac
    22801 tttgcctttt acgtcgatgt ctttgagagt ttttttattc atgcctagga gatcctcctt
    22861 caaaatggtt tgcatacagc acgaaaaacg tgaaaccgtc tgttcaagcg ataactccgc
    22921 tagggcagat cgcagtcttt ttcggcacag ggcagttcgt ctaaaagcca gggcagcggc
    22981 tttaggcgaa agcgccggca aagctgctta aaacgcggtc gtttctctat cacagagcgt
    23041 tttctgaaag ccggtcttca tggaaaaagg gaaagggagt ccgtcccctt cccttgtccg
    23101 ctttcattat agcgcttcta ttcgaaagaa ccaagtcagg tcctttttca gctataaatt
    23161 aaagaccttt ttttgcgatg taagctgcaa ggtcaacaac gcggttagag tagccgcttt
    23221 cgttatcgta ccaagagatt acttttacca tgctgccttc cataaccatt gtagaaagag
    23281 catcgattgt agaagagttt ttgtttccgt tgtagtcgcc agaaactaat ggctcttcgc
    23341 tgtagccaag gattccttta aggtcgcctt cagccgcttc tttaagagct gcgtttactt
    23401 cttcagctgt tacttcttgg ttcagttcag caaccaagtc aactagagaa acgtttggag
    23461 ttggaacacg cattgctcca ccgttcagtt tgccttttag ttcaggaaga actagagaaa
    23521 ctgctttagc agcaccagtt gatgttggga tgatgttttc agctgctgca cgcgcacgac
    23581 ggtagtcttt gtgcggaaga tcaaggattt gctgatcgtt tgtgtaagag tgaacagttg
    23641 tcatcatacc gcgtttgatg ccgaatttat cgttaagtac ttttgcaaac ggcgcaaggc
    23701 agtttgttgt gcaagatgcg ttagagataa catcgtggtt agccgcatcg tatttatctt
    23761 cgttaacacc cataacgatt gtgatatctt cttcgttagc aggagcagag atgattactt
    23821 ttttcgcgcc agcttctaag tgtttcgcag cgtctgcgcg ttttgtgaag aaaccagtag
    23881 attcaactac gatttcaacg ccttgtttgc cccagctaag tttagcagga tcgcgttctg
    23941 cagaaacttc aattgttttg ccgttaacaa caaggttgtt accgtcaact gaaacttcag
    24001 cgtctaattt tccgtgtaca gaatcatatt gtaaaaggtg agccagcatg ttagcatctg
    24061 ttaaatcgtt aaccgctact acctcaactt caggattgtt taatgctgcg cggaatacgt
    24121 tacgtccaat acgaccaaaa ccgttaatac cgacttttac tgccatgatt gtttcctcct
    24181 ttaaataagt gagagatatt tatattgagg gattattcat cccttaataa cttctttgcg
    24241 gctccttcgt ctgtgacgag aaccgtgttg cgcggctttt taaagtaagc ctcgatcgct
    24301 tcggcttttg atgatccgcc cgctaccgca ataatatcgg ggatggcgtc tatgtcatcc
    24361 agctgcattc cgacagaatg cactttgtga accacttcgc cgtccgcgtt aaaatagtag
    24421 ccgaacgctt ctgtcaccgc gtcgttatca tctattttct ttaagtcttc taaaggcgtg
    24481 tttctgcgct gagccatagt tttagcttcg ccgattccgt gaaccagcat actcgctgat
    24541 ttaatggtgt tcagcacctc tttgacagaa ggctcttcaa taatagatga ataggcgcct
    24601 tgtgacagct gtcccggaac aaacaaaagc cggtaagtgc ctgaagcctt ctccgccata
    24661 tgcgcgcata tggtgttcgc ctggtttttc acgtcttcgc ctaaaccgcc tcttgcaggc
    24721 acaaacaaaa gctcgcggtt tttagaatcc ggcgtcatca tttcggcgac agcttcaatt
    24781 gtcgtaccgc cagttacagc gacgatattt ttgcctgaaa atcttttttt catacatgcg
    24841 acagccgctc ttcccatttc ttttttgacc catggggatt gatcgctgtc tccggatacg
    24901 ataatggcat ccttcagatt taaacgttct tttaatgtct tttccaaaag agtcaaacct
    24961 aaaacatctt tcatcgtatc ttccaaaaca gaaagcagtt catagccctc ttctgtcaat
    25021 gtcatgccgt ttgtcttaat atcgaccagg ttctgttcct ttaaaaactg aacctcgccc
    25081 ctcagcacac gctcgctgat ttcgagactg gcagacaggc ttcttcgccc gatgggttct
    25141 gtcagcctga tatactgcaa gatttcaaac ctcttttgca taacgagcag aagatcaggc
    25201 aataattttt tttgagcttg tattaactgg ttcatgactc aaacgttcct tccttttttg
    25261 ctggacatta tatgtcccgc tatgacaaaa aacgtcccgt catagccaaa aaaaatcatt
    25321 tctgctttct ttaattattt taacagggtg gaattgttta ttcaactgtt aagagccaat
    25381 tcatcgacaa tattcgcaga gttttcatgc cgcgtcgttt tatccagcaa tattttatcc
    25441 tatatatctt tatcttatac agaaagcgcc aaatggtgca tcccaatata aacagccctt
    25501 cccgtagaaa gggctgtttc attaaagcgt tttcatttta tccaaagctt ttcaatttcc
    25561 tcgagcgatt tgttcttcgt ttccggacag atcgtaacga caaacaggaa acaaaagatg
    25621 ttaatcaccg caaagatcca aaatgtatag gcgagcccga aagaatcgat catcattggc
    25681 acaaactgtc cgatcgccca gtttgctccc cataaaaaga tggtcgcaat gcccgcggcc
    25741 cgcgcacgca gatggttcgg gaagatttca gaaatcataa tccatgtgat cggtccgacc
    25801 gagacacaga aagcagcgac aaaacctaat ataaggacga tcatcatgat cccgcttgtt
    25861 aactcaaaat aaaacgacgt cccgattaaa atcataaaaa tagccataaa agcagaaccg
    25921 atggacatca gtttttttcg tccgacttta tcaatcagca ataccgcaat aacggtaaag
    25981 atgacttcta caaccccgac gatacaagtc gtcacaaatc cggcgttttg cccgaatccc
    26041 atcattttaa agatttccgg cccgtagtaa gtaatcgcgt tcatgccaat gacttggtta
    26101 aacagcgcca gcaggattcc aatgacaagc gcctttctga gacccggctt aaacagctgg
    26161 gagagcgacc ccatttgttc tatttttaat gagttctcaa tgttctttaa ttcttctttt
    26221 gcaacagttt ctccattaat acgtgtcagg atctttaaag cttcatttgt tttgcccgct
    26281 ttcgccagcc atctcggact ttccgggacg acgagaagga caaggaaaaa gatgacggac
    26341 ggcaccattc cataag
//
