LOCUS       NZ_CP072827            22629 bp    DNA     linear   CON 18-JAN-2024
DEFINITION  Streptomyces mobaraensis NBRC 13819 = DSM 40847 chromosome, complete
            genome.
ACCESSION   NZ_CP072827
VERSION     NZ_CP072827.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces mobaraensis NBRC 13819 = DSM 40847
  ORGANISM  Streptomyces mobaraensis NBRC 13819 = DSM 40847
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 7574085)
  AUTHORS   Li,P.
  TITLE     Telomere system of Streptomyces mobaraensis DSM40847 linear
            chromosome
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 7574085)
  AUTHORS   Li,P.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-MAR-2021) Institution of Microbiology, Jiangxi Academy
            of Science, Changdong Road 7777, Nanchang 330012, China
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly         :: AORZ00000000
            Genome Coverage                   :: 60.0x
            Sequencing Technology             :: Illumina NovaSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Date                   :: 01/18/2024 06:31:43
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.6
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,545
            CDSs (total)                      :: 6,448
            Genes (coding)                    :: 6,310
            CDSs (with protein)               :: 6,310
            Genes (RNA)                       :: 97
            rRNAs                             :: 7, 7, 7 (5S, 16S, 23S)
            complete rRNAs                    :: 7, 7, 7 (5S, 16S, 23S)
            tRNAs                             :: 73
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 138
            CDSs (without protein)            :: 138
            Pseudo Genes (ambiguous residues) :: 0 of 138
            Pseudo Genes (frameshifted)       :: 23 of 138
            Pseudo Genes (incomplete)         :: 120 of 138
            Pseudo Genes (internal stop)      :: 5 of 138
            Pseudo Genes (multiple problems)  :: 9 of 138
            CRISPR Arrays                     :: 5
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 02:35:41
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2022575
            Orig. end                         :: 2045204
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP072827.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22629
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="12"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22629
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22629
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12629](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12629
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     gene            complement(759..1280)
                     /locus_tag="J7W19_RS08215"
                     /old_locus_tag="J7W19_08215"
     CDS             complement(759..1280)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060022.1"
                     /locus_tag="J7W19_RS08215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08215"
                     /product="SAV_6107 family HEPN domain-containing protein"
                     /protein_id="WP_004946558.1"
                     /transl_table=11
                     /translation="MARSRNDVRPSPRPAAPGVWDVPPPAHAVAPPAAAEHLAQARRAL
                     VEAAALDAPHERFATAHLAALRTAAAVLAARGRPETTAGRRHRIRSAWEVLPEAVPELA
                     EWSALFAAGAARRARAEAGIASAANEREADELLRAAAMFLRLVERGLVLQPRLPAQPAP
                     GRGGVGVNGG"
     misc_feature    1423..1438
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 16.6"
                     /tool="antismash"
     misc_feature    1427..1436
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.14"
                     /tool="antismash"
     misc_feature    1434..1449
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.65"
                     /tool="antismash"
     gene            1509..2237
                     /locus_tag="J7W19_RS08220"
                     /old_locus_tag="J7W19_08220"
     CDS             1509..2237
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018555512.1"
                     /locus_tag="J7W19_RS08220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08220"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_004946561.1"
                     /transl_table=11
                     /translation="MDRTSLGAAVAARGLGVAGPRGWTFRAVDVAAAPGDLVAVEGPSG
                     SGRTCLLLTLTGRMRPTAGTAEVGGLPLPRRMAAVRRITALAQIAGVCEPEGALSVGEH
                     LRERVLLCRRFTGGPRALFRPPAEAAERAEAALATVGLDPDALPAGPRTLARDLGRPES
                     LRLSLALALIGGPRLIAVDDADLKLGPADRADAWALLRSVAASGPTVLAVCGEAPEDAD
                     AVVTTHGKETADAFAAAGRA"
     gene            2209..4344
                     /locus_tag="J7W19_RS08225"
                     /old_locus_tag="J7W19_08225"
     CDS             2209..4344
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010039317.1"
                     /locus_tag="J7W19_RS08225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08225"
                     /product="YhgE/Pip domain-containing protein"
                     /protein_id="WP_004946565.1"
                     /transl_table=11
                     /translation="MRSPRLAALELRKFGRGALPRAALVALLLLPLLYGALYLWSFWDP
                     YGRLDKVPVALVNADRGATVDGKRLTAGDSIVDGLRDSRTFRWRETGAEEARKGLEDGT
                     YYLSLTIPADFSRRIASSAGDSPETGALQVRTNDANNYIVGSISRTVFSEVRAAASRKA
                     SRSFYDRIFVSFSTLHGKTQEAAEGADKLGDGIGTARKGAGDLKDGLDKAAEGSGRLRS
                     GVGELYGGAGKLDDASGRLADGAGKVAAGTRKLADRVNGAAASPDARYVKEHAREIGED
                     ARKVAAEARTLRRHLDDLPSAATTAKLARGSAAGAEVLGDSYAELCERAAEPPAFCPKL
                     RKALFAARQSALGARELDTLVQNRNGELDAFPAKLDALRSGAEKLRDKAPTLASEIDAA
                     VRDVNALDSGAHRVADGAGKLHDGAGKLRDGLGTASKGAAGLDDGLGKLRDGADRLQGG
                     MVKLSDGSSKLAGGLHDGAKRIPDYGKDERDARTGVMADPVGLASRATHKAPNYGTGFA
                     PYFIPLSLWVGAMVAYMLFPPLNRRALAAGAPAWRTALAGWLPVVAVGVLQAAALLAVL
                     CWGLGLHLARAAGTIGFLCLVTASFAAIVQWLNARFGPAGRILVLMLLMLQLTSAGGTY
                     PVQTSPGFFNALHPFLPMSYVVDGLRHLITGGDPAAVWRACAVLAAFAAGALALTAWTA
                     RRRQVWTVRDLHPELSL"
     misc_feature    complement(4394..4409)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 15.24"
                     /tool="antismash"
     gene            4407..5021
                     /locus_tag="J7W19_RS08230"
                     /old_locus_tag="J7W19_08230"
     CDS             4407..5021
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983725.1"
                     /locus_tag="J7W19_RS08230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08230"
                     /product="TetR family transcriptional regulator"
                     /protein_id="WP_004946568.1"
                     /transl_table=11
                     /translation="MDSSSTRRGRTRRRLFEAAVTLIAEQGFSSTTVDEIAERAGVAKG
                     TVYYNFASKTVLFEELLRDGIELLTVSLRQAADDTAARGGGRVDALDAMVRAGLDFIAR
                     YPALMQLYVAELWRTNRAWQSTLMQVRQKAIAVIEGVLAEAVAEGELSPEIDVPLTASA
                     LFGMVLVAALDWQSFQPERSVEEVHAALSRLLQGRVGGHAC"
     gene            5215..5826
                     /locus_tag="J7W19_RS08235"
                     /old_locus_tag="J7W19_08235"
     CDS             5215..5826
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010350426.1"
                     /locus_tag="J7W19_RS08235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08235"
                     /product="DUF4126 domain-containing protein"
                     /protein_id="WP_004946572.1"
                     /transl_table=11
                     /translation="MSVLPMVFTSGWASGINAYAVVLLLGLFGRAGVGGDVPEALQRPE
                     VLIVAGVLFLCEAVADKIPYVDTVWDAVHTLVRPACGAMVGALLAGQSGGSLSEAAYGA
                     LGGTTALVMHLVKMSTRMAVNTSPEPLSNILLSAAEDLGVAALVVFALFHPAVAAGIAG
                     TLLVLGIGTVVVLWRRVRAFWRRRKERKAARREGRATAPA"
     misc_feature    5251..5264
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.74"
                     /tool="antismash"
     misc_feature    5860..5874
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.56"
                     /tool="antismash"
     gene            5876..7336
                     /locus_tag="J7W19_RS08240"
                     /old_locus_tag="J7W19_08240"
     CDS             5876..7336
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015576837.1"
                     /locus_tag="J7W19_RS08240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08240"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_040890320.1"
                     /transl_table=11
                     /translation="MARIAVIGAGMGAMAAAARLAVAGHTVTVYERGETHGGGVGRFAR
                     DGFVFDTGPQLLHLPAVYRDLFVKTGKESLEQSVGLTQVDPASAHLFADGTAFALPNAS
                     RAGVVRALDEAVGTGAGERWSELVNRAREAWDATRRPLLEEPLSADPAERAALARDAYP
                     ARRGLFRRSAPATLAAVAARELRDPRLTALLESHALAYGLDPRTAPASATVLPYLEQTF
                     GSWYVAGGLRGLADALHRRCVARRVEFRFGAEVAGVVEEDGRAAGVRLADGTVEEAAFV
                     VTGAPDAASAPSSPGRFTVFLALRGERPAGVAHRTVVHAASRERELAGVFDAAGPDYAP
                     TVTVLRPDDPAVRPDAGHEAITLTATVAPHGRVDWADAEVVTAFADRMLLAAEAAVPGL
                     AERVVWREVRTPADTERVTGAPGGGVPAPALSGGGGAFLFPGNAAELTGLYRVGGFAHP
                     GGGLAHAGMSGALVAGLIVEGEGFRGSQ"
     gene            complement(7553..8431)
                     /locus_tag="J7W19_RS08245"
                     /old_locus_tag="J7W19_08245"
     CDS             complement(7553..8431)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019885556.1"
                     /locus_tag="J7W19_RS08245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08245"
                     /product="hypothetical protein"
                     /protein_id="WP_004946578.1"
                     /transl_table=11
                     /translation="MGWTVLYIAFGVVGLWLLGEVLFQYKARLRWRLLAFTGFLGVVAG
                     VVIPSVAVIAVGAVAFAIGQVYVTLSFRRGFSAGWALRRKGRDEAGPAASGPAPGSRSR
                     SASRGGGGRRRGRPERGATAAPAASDAPPAPGTPGAGRKRLTAAEAGAATAMMPTVPQQ
                     PTDEHGMPGPAAPGPGDTAAFPVVEEAASVFGGGGYGYGQGQEQYPAYSDPYIGAGAGV
                     QPAPGYEQPYDAYGQQGAYPQQYGQQQGQQYGQYGQYDMDTPPGGVWVPQQRQGGGEGQ
                     VPPAPPQGYGY"
     gene            complement(8472..9389)
                     /gene="metF"
                     /locus_tag="J7W19_RS08250"
                     /old_locus_tag="J7W19_08250"
     CDS             complement(8472..9389)
                     /EC_number="1.5.1.20"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014060028.1"
                     /locus_tag="J7W19_RS08250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08250"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_051072631.1"
                     /transl_table=11
                     /translation="MALGTASTRTDHARTVRDLLASGERSYSFEFAAPKTEKGERTLWN
                     AIRRIEAVAPTFVSVTYGAGGSSREGTVRATERIATDTTLTPVAHLTAVNHSVAELRNV
                     IGQYADVGIRNMLALRGDPPGDPTGEWVRHPQGLHYAVELVRLIKESGDFCVGVAAFPE
                     MHPRSTDWDTDVRHFVDKCRAGADFAITQMFFHADDYLRLRDRVHAAGCETPIIPEIMP
                     VTNVRQIERFAQLSNAAFPADLAERIRAVEDDPAAVRSIGIEYATELCARLMAEETPGL
                     HFITLNHSTATLEIYENLGLHQRS"
     misc_feature    9619..9634
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 17.84"
                     /tool="antismash"
     misc_feature    complement(9697..9711)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 13.9"
                     /tool="antismash"
     gene            9866..9976
                     /locus_tag="J7W19_RS08255"
                     /old_locus_tag="J7W19_08255"
     CDS             9866..9976
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015656044.1"
                     /locus_tag="J7W19_RS08255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08255"
                     /product="keywimysin-related RiPP"
                     /protein_id="WP_106429645.1"
                     /transl_table=11
                     /translation="MKKTYEAPTLVKRGTFRAKTGLLRTSGNDRLILSKN"
     gene            10001..11077
                     /locus_tag="J7W19_RS33630"
     CDS             10001..11077
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="J7W19_RS33630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_275450989.1"
                     /sec_met_domain="Asn_synthase (E-value: 7.5e-14, bitscore:
                     50.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTPREAGGAGPGAASFVVLPDCDDALTAARSLIRQDTRDSQDIQ
                     DIQAPHYTRTIPHPSGRPWIAGRWHDEDVTAVRAGRAALAVIGCCPVRPEELRRRAEAL
                     RDLTALDALARALPGRFHLVAALDGAVRVQGTASGLRLVHRATVGGVEVAASDALPLAR
                     ALDSTPDEEELAVRLLWPVPHPLFATSPWRGVTAVPAEDALYVSRDGRTVRHSRWWTPP
                     EPVRSMAGGAPLVRQALTEAVAARTHRGSTVSCDLSGGLDSTSVCFLAAASPARVIAST
                     WPGRDPADSDLAWARRAARHLPHVEHVVWDADESPLVYTDLLDIDEPMDEPTIGVMDRA
                     RVRCTTSRSSPAAAVRRT"
     gene            11083..11874
                     /locus_tag="J7W19_RS33635"
     CDS             11083..11874
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012936.4"
                     /locus_tag="J7W19_RS33635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_275450990.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.3e-21, bitscore:
                     76.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGDHVAWCSEGYYHRLLRTRPWFALRQLRGFRTLYQWPLAPAVR
                     TLADSRPYGRWLAGTAARLRDPLPPGVEGALGWGTAPRLFPWVTPEAAEAARRALLRAA
                     ATAEPLHRDRGLHQDLEQIRICTRIVRQWDLMAARTGLPTASPFFDDRVIEACLAVDPR
                     ARVTPWAYKPLLGAAMRGIVPDACLARTDKAHASMDASNGLREHRGDLVKLWEDSSLAR
                     LGLVDAGELTALAQRPATPGLGDAILYSTIGCEVWLRTLAR"
     aSDomain        11932..12084
                     /aSDomain="Lasso_Fused_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing fused peptidase in a lasso
                     peptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_J7W19_RS08265_Lasso_Fused_RRE.1"
                     /evalue="1.50E-09"
                     /identifier="RREFam003.1"
                     /label="J7W19_RS08265"
                     /locus_tag="J7W19_RS08265"
                     /protein_end="51"
                     /protein_start="0"
                     /score="28.8"
                     /tool="antismash"
                     /translation="MALRFAPDVATAETEYGTVLLDQRKGRYWELNPTGTLVVRTLLDG
                     GGEADA"
     gene            11932..12186
                     /locus_tag="J7W19_RS08265"
                     /old_locus_tag="J7W19_08265"
     CDS             11932..12186
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lasso_Fused_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638601.1"
                     /locus_tag="J7W19_RS08265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08265"
                     /product="lasso peptide biosynthesis PqqD family chaperone"
                     /protein_id="WP_004946593.1"
                     /sec_met_domain="Lasso_Fused_RRE (E-value: 3.5e-07,
                     bitscore: 28.8, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 9e-25,
                     bitscore: 85.1, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 2.4e-14, bitscore: 51.9,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALRFAPDVATAETEYGTVLLDQRKGRYWELNPTGTLVVRTLLDG
                     GGEADAVEALVGAFAVDRERAAADVAALVALLRDAGLAA"
     aSDomain        11935..12180
                     /aSDomain="Stand_Alone_Lasso_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="Stand-alone RRE protein in a lasso peptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_J7W19_RS08265_Stand_Alone_Lasso_RRE.1
                     "
                     /evalue="3.90E-27"
                     /identifier="RREFam002.1"
                     /label="J7W19_RS08265"
                     /locus_tag="J7W19_RS08265"
                     /protein_end="83"
                     /protein_start="1"
                     /score="85.1"
                     /tool="antismash"
                     /translation="ALRFAPDVATAETEYGTVLLDQRKGRYWELNPTGTLVVRTLLDGG
                     GEADAVEALVGAFAVDRERAAADVAALVALLRDAGLA"
     gene            12183..12629
                     /locus_tag="J7W19_RS08270"
                     /old_locus_tag="J7W19_08270"
     CDS             12183..12629
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003990137.1"
                     /locus_tag="J7W19_RS08270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08270"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_004946594.1"
                     /sec_met_domain="PF13471 (E-value: 7.4e-27, bitscore: 92.3,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTPSALVRPSDVPFPRRLAARLALAVAFPLALLPPHRLRAVLAV
                     LRRGAAPASYERAGAARRAVCAVSLYCAGPRGCLPRSLGTALLCRFGGCWPTWCTGVRK
                     VPPFSAHAWVEAEGRPVDEGVPDDYFGRLLTVAPGPSPRKRPLP"
     gene            12626..14413
                     /locus_tag="J7W19_RS08275"
                     /old_locus_tag="J7W19_08275"
     CDS             12626..14413
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016638599.1"
                     /locus_tag="J7W19_RS08275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08275"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_004946595.1"
                     /transl_table=11
                     /translation="MTPAGTGRRDGPGAVRTVFRLTAGHRAALTTAIVLTLVGSALGLA
                     QPLLAQRIVDASADGRPLWPLVFLAVLFAAEAGTASVGRFLQERMGEGVVRGLRHRLTG
                     RLLRLEMREYEHHRTGDLVSRVTVDTTVLREVLSQALVDLVTGSLASAGAVALMLWLDP
                     LLLLLVALTVAAAAAVVTGVLSGLRTASERTQHAVGAIAADLERALGALPMVRVHRAEE
                     REAARIGERVDAAYGAGVRTARLAAVMSPAVELAVHGSFLLVLVIGGLRVDGRTHSLGD
                     LVAFLLYASYLVVPLSSVFHAAGLLQRGVGALGRVEEALALPVEPAGAEPPGPDEPCAP
                     APSPVSPAPSSPPVLALEDVRFGYRPGRPVLRGVSLEVPPHRQVALVGRSGAGKSTVFA
                     LAARFYEPDAGRLLFDGRPAAGMTRAECRARIAVVDQNTHVVHGSLWDNITYTAPGASR
                     AEVRRVVELARLDEVVDRLPGGLDGPVGERGASLSGGERQRVALARALLTRPALLLLDE
                     PTSQLDAVNELALGRVMREITEECALLVIAHRLSTVQNADRIVVLHEGRAVASGRHEDL
                     LSGCAAYRELAAAQMLRTG"
     gene            complement(14431..14910)
                     /locus_tag="J7W19_RS08280"
                     /old_locus_tag="J7W19_08280"
     CDS             complement(14431..14910)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="J7W19_RS08280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="J7W19_08280"
                     /product="hypothetical protein"
                     /protein_id="WP_004946599.1"
                     /transl_table=11
                     /translation="MRKAAQITGAALIAAVLMTGCSSGSDDKDGKKDEAKPARSAGQSA
                     APSEGAKGAGAEDKLISSPGGAYLAQSAEGPVALTIVAGQAALASDGGKRTCSGTVSGK
                     SLTLKCSDGGDKRTRGIIEKSDATSMVVSWEGGPKETFARQSGGAKLPGLPKLGG"
     gene            complement(14981..15658)
                     /gene="thiE"
                     /locus_tag="J7W19_RS08285"
                     /old_locus_tag="J7W19_08285"
     CDS             complement(14981..15658)
                     /EC_number="2.5.1.3"
                     /GO_function="GO:0004789 - thiamine-phosphate
                     diphosphorylase activity [Evidence IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1280: thiamine-phosphate pyrophosphorylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018848777.1"
                     /locus_tag="J7W19_RS08285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08285"
                     /product="thiamine phosphate synthase"
                     /protein_id="WP_004946602.1"
                     /transl_table=11
                     /translation="MSATARTLPHAPTAREALAGARLYLCTDARKRQGDLPEFLDAVLA
                     GGVDVVQLRDKGMEAGEELEHLAVLADAARRHGRLLAVNDRADVAHAIRSDVLHLGQGD
                     LPVPAARAVLGDDVLIGRSTHSEAEAEAAMREPGVDYFCTGPCWPTPTKPGRPAPGLSL
                     VRHTAALRPERPWFAIGGIDERNLDEVLDAGARRVVVVRALTEADDPGDAAARLARRIR
                     ERD"
     gene            complement(15737..16102)
                     /locus_tag="J7W19_RS08290"
                     /old_locus_tag="J7W19_08290"
     CDS             complement(15737..16102)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020129955.1"
                     /locus_tag="J7W19_RS08290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08290"
                     /product="Rv2175c family DNA-binding protein"
                     /protein_id="WP_004946605.1"
                     /transl_table=11
                     /translation="MTEIDTKIDALVSEWLTLPDIAEMLDVEVTRVRQLVKEGQLIAVR
                     RGENRVLQVPAAFIGEGKVVKGLAGTLTLLKDDGFTDEEMLEWLFTPDPTLPGTPAQAL
                     RENRGTEVKRRAQALAV"
     gene            complement(16268..17437)
                     /locus_tag="J7W19_RS08295"
                     /old_locus_tag="J7W19_08295"
     CDS             complement(16268..17437)
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175: pyridine nucleotide-disulfide oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019885561.1"
                     /locus_tag="J7W19_RS08295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08295"
                     /product="FAD-dependent oxidoreductase"
                     /protein_id="WP_233478246.1"
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.2e-50, bitscore:
                     170.9, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGVQTAVALREQGWEGTITLLGAEPHPPYDRPPLSKAVLLGKAD
                     GSAFEVDFASLDIELRLGLEVTGLRPADHEVDTPGGPVPYDVLVVATGAEPVRLPGAED
                     LPGVHLLRTLDDAERLRPLLERKGDVVAVGAGWIGAEFATAAREAGCRVTVVEAADRPL
                     AGALPAEVAAHMADWYGQSGARLLTGARVAALEPGAVLLADGTRLTADAVVVGIGARPA
                     TGWLAGSGVELAADRSVVTDDRLRTSVPDVYAVGDCASFPSARYGERLLVHHWDNALQG
                     PKTVAANIVHGPAEGPVYDPVPYFWSEQFGRFVQYAGHHAAADELVWRGDPAGAAWTVC
                     WLRGGVLVAVLAVGRPRDLAQGRKLIEKGAVVDRERVADPAVPLKSAVG"
     regulatory      17683..17795
                     /bound_moiety="thiamine pyrophosphate"
                     /db_xref="RFAM:RF00059"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00059"
                     /inference="COORDINATES: profile:INFERNAL:1.1.4"
                     /note="TPP riboswitch; Derived by automated computational
                     analysis using gene prediction method: cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17752..17765)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.18"
                     /tool="antismash"
     misc_feature    17784..17797
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.42"
                     /tool="antismash"
     gene            17793..18989
                     /gene="thiO"
                     /locus_tag="J7W19_RS08300"
                     /old_locus_tag="J7W19_08300"
     CDS             17793..18989
                     /EC_number="1.4.3.19"
                     /GO_function="GO:0016647 - oxidoreductase activity, acting
                     on the CH-NH group of donors, oxygen as acceptor [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="thiO"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1103: FAD dependent oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014180425.1"
                     /locus_tag="J7W19_RS08300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08300"
                     /product="glycine oxidase ThiO"
                     /protein_id="WP_004946610.1"
                     /sec_met_domain="DAO (E-value: 3.5e-67, bitscore: 226.0,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHASTRTGPYDVLVIGGGIIGLVTAWRAAQRGLRTAVADPSPGGG
                     AALVAAGMLAAVTELHYGEQALLALNLASARRYPDFTAELEEASGRDTGYRACGTLAVA
                     LDADDRAHLRELGAFQRRCGLEAEWLTGRECRRLEPMLAPGVQGGLRVDGDHQTDPRRL
                     AAALLTACERAGVTLRRAAVARVLLDGDRAAGAELADGERIAAGQTVLAAGSHSARVAG
                     LPDAVLPPVRPVKGQTLRLRIPEAYRPFLSRTVRAVVRGNPVYLVPRENGELVIGATTE
                     ELGWDTTVTAGGVYELLRDAHELVPGLTELPLAETSAGLRPGSPDNAPLLGPTDLPGLH
                     LATGHHRNGVLLTPLTGDVMAEALTTGRLPEEARPFTPRRFAAPAGPRPASPVQEPSA"
     gene            18986..19207
                     /gene="thiS"
                     /locus_tag="J7W19_RS08305"
                     /old_locus_tag="J7W19_08305"
     CDS             18986..19207
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009228 - thiamine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="thiS"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014156720.1"
                     /locus_tag="J7W19_RS08305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08305"
                     /product="sulfur carrier protein ThiS"
                     /protein_id="WP_004946612.1"
                     /transl_table=11
                     /translation="MTDVHTVHVNGERRAVPSGTTLATLVAGLTGRPDSPGGVAAAVNE
                     AVVPRGRWADTPLRDGDRVEVLTAVQGG"
     gene            19209..20012
                     /locus_tag="J7W19_RS08310"
                     /old_locus_tag="J7W19_08310"
     CDS             19209..20012
                     /EC_number="2.8.1.10"
                     /GO_function="GO:1990107 - thiazole synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018557084.1"
                     /locus_tag="J7W19_RS08310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08310"
                     /product="thiazole synthase"
                     /protein_id="WP_004946614.1"
                     /transl_table=11
                     /translation="MADDVLTIAGTPFTSRLIMGTGGAPSLDVLERALLASGTELTTVA
                     MRRLDPAVRGSVLSVLERHGIRVLPNTAGCFTAGEAVLTARLAREALGTDWVKLEVIAD
                     ERTLLPDPIELLDAAEILVDDGFTVLPYTNDDPVLARRLEDVGCAAIMPLGSPIGSGLG
                     IRNPHNFQLITERAKVPVILDAGAGTASDAALAMELGCAAVMLASAVTRAQEPVLMAEA
                     MRHAVEAGRLAHRAGRIPRRHFAEASSPTAGMAVLDPERPAFSAR"
     gene            20307..22271
                     /gene="pknB"
                     /locus_tag="J7W19_RS08315"
                     /old_locus_tag="J7W19_08315"
     CDS             20307..22271
                     /GO_function="GO:0004672 - protein kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006468 - protein phosphorylation [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="pknB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983714.1"
                     /locus_tag="J7W19_RS08315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="J7W19_08315"
                     /product="Stk1 family PASTA domain-containing Ser/Thr
                     kinase"
                     /protein_id="WP_004946616.1"
                     /sec_met_domain="Pkinase (E-value: 3.1e-53, bitscore:
                     179.3, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTTLPDPLVDRLLDGRYRIQARVAAGGMATVYRALDTRLDRVLA
                     VKVMHPALAADKVFVERFIREAKSAARLDHPNVVSVYDQGTDGGYVYLAMEYVAGCTLR
                     DVLRERGALQPRAALDIAEPVLAALGAAHRAGLVHRDMKPENVLIGDDGRVKVADFGLA
                     RTVGTNSATNTGSILGTVSYLAPEQIEHGTADTRTDVYACGVVLYEMLTGVKPHSGASP
                     AQILYQHLHRDVPPPSQEVPGLAPELDDLVTVATARDPELRPSDAVGMLGLVRAARATL
                     TREQLDARPPLAAGPAVAGDDEEATSVLPRPVTAQPLPPAEAPEPDPMDMTARFDGPPE
                     PPPPPAPPARPRRFAALRRRPRRAVLVVAGVLLALLAGTGVWYINAGQFTSVPAVLDLT
                     QAQAEKKLDKAGLKVRVQPEFSDTVERGHVMSTDPKPGERIRNTGRVTVVVSRGPERAE
                     VPNVVGMRLDDAKKRITQAGLTVGDVRTQFSDETPQGEVLSSDPRGGDERRPDSPVSLI
                     VSKGEPVEVPDVSGLSPDDAQSTLSDAGLRIRVSDAQVYSDREKGDVAEQSPARGVQVA
                     KGDTVTVTLSKGKEMLTVPDVTGRSEADAKRILTSAGFQVRVDRPFFFPKDSVESQSVR
                     AGDKAARGDTVTIRLKGAL"
     misc_feature    20335..20350
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.12"
                     /tool="antismash"
     misc_feature    22447..22461
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.53"
                     /tool="antismash"
ORIGIN
        1 cggcgaccag ctccgacagc tggtcggcgg tgaagcggcg cggtacgggg tcgccggcgc
       61 cccagtgccc cgcggggtcg gtgagggcct gccgggcctc ggcgaagtgg ccggcgaggg
      121 cgcgggcgag gaccgccccg ccgaggccgg cggcgagcag gctgagcacg ccggaggggc
      181 gcagggcggc ggcgacggcc cgcaggccct cggcggggtc gtccacgtac tccaggacgc
      241 cgtggcagag gacggcgtcg tacgcgccgc ggccgaccac gtcgaacagg ttctgggtgt
      301 cgccctggac cccgcgcacc cggtcggcga cgccggcctc ggcggcccgg cgctccagcg
      361 cgaacagcgc gttggggctg gggtccacga cggtgacccg gtgaccgagg cgggcggcct
      421 cgacggcgaa ctggccgctg ccgccgcccg cgtccaggac ctccagtccg gcaccggcac
      481 cgccgccggt acccccgccg gcactctgac cgaccgcagc ccgccggtcg agggcgtccc
      541 gcaggacctc ccagaccacg gcggtacgca gggacgcacg ggggcgcgat ggggtctccc
      601 cacccaggga aggctcggac acggcgggtg gctcctcggc gcgggtggcg gcaccgccgg
      661 tgcggcggtg gcggatgacg gtcgtcggcg gtcccagcct aatgggccgg gtcccggccg
      721 cccgcacgcc gctcccccgt gggccgcggc gggcccggtc acccgccgtt cacccccacc
      781 ccgccgcggc cgggggcggg ttgcgcgggg agccggggct ggaggaccag cccccgttcg
      841 acgagccgca ggaacatcgc cgccgcgcgc agcagctcgt cggcctcccg ttcgttcgcc
      901 gccgacgcta tcccggcctc ggcccgggcc cggcgggcgg ccccggcggc gaacagggcg
      961 ctccactccg cgagttcggg aacggcctcg ggcaggacct cccaggcgct gcggatccgg
     1021 tgccgccggc cggccgtggt ctccggccgg ccccgggcgg cgagcacggc ggcggcggtg
     1081 cgcagcgcgg cgaggtgggc ggtggcgaac cgctcgtgcg gggcgtcgag ggcggcggcc
     1141 tccaccaggg cccgccgggc ctgggcgagg tgctcggcgg cggcgggcgg cgcgacggcg
     1201 tgggcgggcg ggggtacgtc ccagacgccc ggggcggccg ggcgcgggga agggcggacg
     1261 tcgttcctgc tgcgggccat gacgaacctc cttcgtcggg gcggtccggg cggatgcccg
     1321 taccaccgtc tgcccttatc gtcctgcacc ccactgacaa tcggcctgac ctgcaaggac
     1381 attgggaatg ccaccccgcc ggcgggggca ggggaagggt gcgccatact ttttgcactg
     1441 actggtcagt gcaagtgcag gacgctcacg caagccgcac caccgccacg tcacctggag
     1501 gccgtcgtat ggaccgcacc tcgctcgggg ccgccgtcgc ggcccgcgga ctcggcgtcg
     1561 ccgggccccg cggctggacg ttccgcgccg tggacgtcgc cgccgccccc ggcgacctcg
     1621 tcgccgtcga aggcccgtcc ggctcgggcc gtacctgtct tctgctcacg ctcaccggaa
     1681 gaatgcgccc caccgccggg acggccgagg tcggcggcct gccgctgccc cgccggatgg
     1741 ccgctgtccg ccggatcacg gcgctcgccc agatcgccgg cgtctgcgaa ccggagggcg
     1801 cgctgagcgt cggggagcac ctgcgggaac gggtgctgct gtgccgccgg ttcaccggtg
     1861 gcccccgcgc gctgttccgt cctccggccg aggccgccga gcgcgccgag gcggccctcg
     1921 cgaccgtcgg cctcgacccg gacgcgctgc ccgccggccc ccgtaccctc gcccgcgacc
     1981 tcggccggcc ggagtcgctg cggctgtccc tcgccctggc cctgatcggc ggcccgcgcc
     2041 tgatcgccgt cgacgacgcc gacctcaaac tcggccccgc cgaccgcgcg gacgcctggg
     2101 cgctgctgcg gtccgtcgcg gcgtccggcc ccaccgtgct cgccgtctgc ggcgaggcgc
     2161 cggaggacgc cgacgccgtc gtcaccaccc acgggaagga gacggcggat gcgttcgccg
     2221 cggctggccg cgcttgagct caggaagttc ggcaggggcg ccctgccgcg cgccgcgctc
     2281 gtcgcgctgc tgctcctccc gctgctctac ggggccctgt acctctggtc gttctgggac
     2341 ccctacgggc ggctcgacaa ggtacccgtg gcgctggtga acgccgaccg gggcgccacc
     2401 gtggacggca agcggctcac cgccggcgac tccatcgtcg acggcctgcg cgacagcagg
     2461 acgttccggt ggcgggagac cggtgccgag gaggcccgga agggcctgga ggacggcacg
     2521 tactacctgt cgctcaccat ccccgccgac ttcagccggc ggatcgcctc cagcgccggg
     2581 gactccccgg agaccggggc gctccaggtc cggacgaacg acgccaacaa ctacatcgtc
     2641 ggctccatat cccgcaccgt cttctccgag gtccgcgccg ccgcctcgcg caaggcgtcc
     2701 cgctccttct acgaccggat cttcgtctcc ttctccaccc tgcacgggaa gacccaggag
     2761 gccgccgagg gcgcggacaa gctgggcgac ggcatcggca ccgcccgcaa gggcgcaggc
     2821 gacctcaagg acggcctgga caaggccgcg gagggcagcg ggcggctgcg gagcggcgtc
     2881 ggcgaactgt acggcggcgc cgggaagctg gacgacgcct cggggcgact cgccgacggc
     2941 gcgggcaagg tggcggccgg cacccggaag ctcgccgacc gggtcaacgg cgcggcggcg
     3001 agcccggacg cccgctacgt gaaggagcac gcccgcgaga tcggcgagga cgcccgcaag
     3061 gtggccgccg aggcgcggac gctccgccgg cacctggacg acctgccgtc cgccgccacc
     3121 accgcgaagc tcgcccgggg cagcgcggcc ggcgccgagg tgctcggcga ctcctacgcc
     3181 gagctctgcg aacgggccgc cgaacccccg gcgttctgcc cgaagctgcg caaggcgctg
     3241 ttcgccgccc ggcagtccgc cctgggcgcc cgcgagctcg acaccctcgt acagaaccgg
     3301 aacggcgaac tcgacgcgtt cccggccaaa ctggacgccc tccgctccgg cgccgagaag
     3361 ctgcgcgaca aggcgcccac gctggcgtcc gagatcgacg ccgccgtccg cgacgtcaac
     3421 gccctcgact ccggcgccca ccgcgtcgcc gacggcgcgg ggaagctgca cgacggcgcc
     3481 gggaagctgc gcgacggcct cggcaccgcg agcaagggcg ccgccggcct cgacgacggg
     3541 ctcgggaagc tgcgcgacgg cgccgacagg ctccagggcg gcatggtcaa gctctccgac
     3601 ggctcgtcca agctggccgg cgggctgcac gacggtgcca agcggatccc cgactacggc
     3661 aaggacgagc gcgacgcccg gaccggcgtc atggccgacc cggtcggact cgcctcccgc
     3721 gccacccaca aggcgcccaa ctacggcacc ggcttcgccc cgtacttcat cccgctctcc
     3781 ctctgggtcg gcgcgatggt ggcctacatg ctgttcccgc cgctcaaccg gcgcgccctg
     3841 gccgcgggtg ccccggcctg gcggaccgcc ctcgcgggct ggctgccggt cgtcgcggtc
     3901 ggggtgctcc aggccgccgc gctgctggcc gtcctgtgct gggggctggg cctgcacctg
     3961 gcccgcgcgg cgggcacgat cggcttcctg tgcctggtga cggcgtcctt cgccgcgatc
     4021 gtgcagtggc tcaacgcccg cttcggcccg gccggccgga tcctcgtcct gatgctgctg
     4081 atgctccagc tgacgtcggc gggcggcacc tacccggtgc agaccagccc cggcttcttc
     4141 aacgcgctgc accccttcct gcccatgagc tacgtggtcg acgggctgcg ccacctcatc
     4201 accggcggcg atccggcggc cgtgtggcgg gcctgtgccg tgctggccgc gttcgccgcg
     4261 ggcgccctgg cgctcaccgc gtggacggcc cggcgccggc aggtgtggac ggtacgggac
     4321 ctgcatccgg agctgagcct gtgaggcccg tgcgtcccgt ggggcccgta ccggaggaca
     4381 cggtgcgtac agggagaatc acccgcatgg acagcagcag tacgcgccgc ggcagaaccc
     4441 ggcgccgcct cttcgaggcg gccgtcaccc tcatcgccga acagggcttc tcctccacca
     4501 ccgtcgacga gatcgccgaa cgcgccgggg tggccaaggg caccgtctac tacaacttcg
     4561 cgagcaagac ggtcctcttc gaggagctcc tgcgggacgg catcgagctg ctgaccgtct
     4621 ccctccggca ggccgcggac gacacggcgg cccgcggcgg cggccgggtg gacgcgctcg
     4681 acgcgatggt gcgggcgggc ctggacttca tcgcccgcta cccggcgctg atgcagctgt
     4741 acgtcgcgga gctgtggcgc accaaccggg cctggcagtc gacgctgatg caggtgcggc
     4801 agaaggcgat cgccgtgatc gagggggtgc tggcagaggc cgtcgccgag ggcgagctga
     4861 gcccggagat cgacgttccg ctgacggcgt cggcgctgtt cgggatggtg ctggtggccg
     4921 cgctggactg gcagtcgttc cagccggagc ggtcggtgga ggaggtgcac gcggcgctgt
     4981 cgcggctgct ccaggggcgc gtgggcgggc acgcctgcta gccggcgggt gacgggcgcc
     5041 cggccccgcg cgcggcgccc gttccgccgc cccgtgccgg cggtgcgggc gccgcgctcc
     5101 cccacggccc cactcttccg cccgccgggg cgggggctca tccgtaccgc tactcacccc
     5161 gtactcaacc cgaggcgtcc ggcgggctga gtacgcccgc ctacgatcgt ccccatgtcc
     5221 gtactcccca tggtgttcac cagcggctgg gcgagcggga tcaacgccta cgcggtggtc
     5281 ctgctgctcg gcctgttcgg cagggccggc gtcggcggcg acgtgcccga ggcgctgcag
     5341 cgtcccgagg tgctgatcgt cgccggtgtg ctgttcctct gcgaggccgt cgccgacaag
     5401 atcccgtacg tggacacggt gtgggacgcc gtccacaccc tggtccggcc cgcctgcgga
     5461 gcgatggtcg gggcgctgct ggccgggcag agcggcggtt cgctctcgga ggcggcctat
     5521 ggggcactgg gcgggacgac ggcgctggtg atgcacctgg tgaagatgag cacgcggatg
     5581 gcggtcaaca cctcgccgga gccgctgagc aacatcctgc tgagcgccgc ggaggatctg
     5641 ggcgtcgccg ccctcgtggt cttcgccctg ttccacccgg cggtcgccgc gggcatcgcg
     5701 gggacgctgc tggtcctggg gatcgggacg gtggtggtcc tgtggcgccg ggtgcgcgcg
     5761 ttctggcgac ggcgcaagga gcggaaggcg gcgcggcggg aggggcgcgc gacggccccg
     5821 gcgtaggcgg aggcggcccc cggcggcgtt tccggttccg gatagggtcg gccgcatggc
     5881 acgaattgcg gtgatcggcg ccggcatggg cgccatggcg gctgccgccc ggctggccgt
     5941 cgccggccac acggtgacgg tgtacgagcg cggcgagacc cacggcggag gcgtcgggcg
     6001 gttcgcccgg gacggcttcg tcttcgacac gggaccgcag ctgctgcacc tgcccgccgt
     6061 ctaccgcgac ctcttcgtca agaccggcaa ggagtccctg gagcagagcg tcggcctcac
     6121 ccaggtggac ccggcgagcg cccatctctt cgccgacggg acggcgttcg cgctgcccaa
     6181 cgcctcgcgc gcgggcgtcg tccgggcgct ggacgaggcg gtgggcacgg gcgcgggcga
     6241 gcgctggagc gagttggtca accgggcccg ggaggcgtgg gacgcgacgc ggcgcccgct
     6301 gctggaggaa ccgctgagcg cggaccccgc ggagcgggcg gccctggccc gcgacgcgta
     6361 cccggcccgg cgcggcctct tccggcgcag cgcgccggcc accctcgcgg ccgtcgccgc
     6421 ccgggaactg cgcgaccccc ggctcaccgc cctgctggag agccacgcgc tggcctacgg
     6481 cctcgacccg cgcaccgcgc cggcgagcgc gaccgtcctg ccgtacctgg agcagacctt
     6541 cggcagctgg tacgtggccg gcgggctgcg cggcctcgcc gacgcgctgc accggcggtg
     6601 cgtggcccgg cgggtggagt tccggttcgg cgccgaagtg gccggtgtgg tcgaggagga
     6661 cggccgcgcg gcgggcgtcc ggctcgcgga cgggacggtc gaggaggcgg cgttcgtcgt
     6721 caccggcgcc ccggacgcgg cttccgcgcc gtcgtccccc ggccggttca ccgtcttcct
     6781 cgccctgcgc ggggagcggc cggcgggggt cgcgcaccgc acggtcgtcc acgcggcgtc
     6841 gcgggaacgc gagttggcgg gcgtcttcga cgccgccggc cctgattacg ccccgacggt
     6901 caccgtcctc cgccccgacg acccggccgt ccggcccgac gccgggcacg aggcgatcac
     6961 cctgacggcg acggtcgctc cgcacggccg cgtcgactgg gcggacgccg aggtcgtcac
     7021 cgcgttcgcc gaccggatgc tcctggccgc cgaggcggcc gttcccgggc tggcggagcg
     7081 ggtggtgtgg cgggaggtgc ggacgccggc cgatacggag cgggtcacgg gggctccggg
     7141 cgggggcgtg cccgcgcccg cgttgagcgg gggtgggggt gcgttccttt tccccggcaa
     7201 cgcggccgag ttgaccgggt tgtaccgggt gggtgggttt gcccatccgg ggggtgggct
     7261 ggcgcacgcg gggatgtcgg gggcgttggt ggcggggttg atcgtggagg gggaagggtt
     7321 tcggggttcg cagtgagggt gccccggccc caccctttca ccgtttcttg caggggctcc
     7381 gcccccgcac ccccgaaacc gcgctccgcg cggttgtcct caaacgccgg acgggctgga
     7441 gtgggcaccc cattcagccc gtccggcgtt tgaggacgag cggcgaagcc gcgaaagcgg
     7501 ggtctggggc gcagccccag gaaacggcga aagggaggga ccggggcacc cctcaatacc
     7561 cgtacccctg cggcggagcc ggcggcacct gcccctcgcc accgccctgc cgctgctgcg
     7621 gcacccacac cccacccggc ggggtgtcca tgtcgtactg cccgtactga ccgtactgct
     7681 gaccctgctg ctggccgtac tgctgcggat aggcaccttg ctgcccgtac gcgtcgtacg
     7741 gctgctcgta ccccggcgcc ggctgcacgc cggccccggc cccgatgtac ggatcggagt
     7801 acgccgggta ctgctcctgg ccctggccgt agccgtatcc gccgccgccg aacacggaag
     7861 ccgcctcctc gacgaccggg aaggccgccg tgtcgccggg ccccggcgcc gcgggcccgg
     7921 gcatcccgtg ctcgtcggtc ggctgctggg gcaccgtcgg catcatggcc gtcgccgcgc
     7981 ccgcctccgc cgccgtcagc cgcttgcggc cggcgcccgg ggtgccgggg gcgggaggcg
     8041 cgtcggacgc ggccggggcc gcggtcgcgc cgcgctcggg gcggccgcgc cggcgcccgc
     8101 cgccgccccg ggaggcggag cgggaacgag aaccgggagc cggaccggaa gcggccggcc
     8161 cggcctcgtc ccggcccttg cgccgcagcg cccagcccgc ggagaagccg cgccggaacg
     8221 acagcgtgac gtagacctgt ccgatcgcga acgcgacggc gccgacggcg atgacggcca
     8281 cggacgggat gacgacaccg gccaccaccc cgaggaagcc ggtgaacgcg agcagccgcc
     8341 accgcagccg ggccttgtac tgaaacagca cttcgccgag cagccacagc ccgacgacgc
     8401 cgaacgcgat gtagaggacc gtccagccca tgaatcgccc ctccagtccg gccgccgcga
     8461 ccggcgggcc gtcaggaccg ctggtgcagt cccaggttct cgtagatttc caaggtggcc
     8521 gtggagtggt tcagggtaat gaagtgcagc cccggagtct cctcggccat caaccgggca
     8581 cacagctccg tcgcgtactc gatcccgatc gagcgtacag ccgccggatc gtcctccacc
     8641 gcgcggatcc gctccgcgag gtccgcgggg aaggcggcgt tgctgagctg cgcgaaccgt
     8701 tcgatctgcc ggacgttggt gacgggcatg atctcgggga tgatcggggt ctcgcagccg
     8761 gcggcgtgga cccggtcgcg gagccgcagg tagtcgtcgg cgtggaagaa catctgggtg
     8821 atggcgaagt cggcgcccgc ccggcacttg tcgacgaagt ggcggacgtc ggtgtcccag
     8881 tcggtggagc gcgggtgcat ctcggggaag gccgcgacgc ccacgcagaa gtcgccggac
     8941 tccttgatga gccgcaccag ttcgacggcg tagtgcagcc cctgggggtg acgcacccac
     9001 tccccggtgg ggtcgccggg cgggtcgccg cgcagggcga gcatgttgcg gatgccgacg
     9061 tccgcgtact ggccgatgac gttgcgcagt tcggccacgg agtggttgac ggcggtgagg
     9121 tgggcgacgg gggtgagggt ggtgtcggtc gcgatgcgct cggtcgcccg tacggtgccc
     9181 tcgcgggagg agccgccggc gccgtaggtc acggagacga aggtcggcgc gaccgcttcg
     9241 atccgccgga tggcgttcca gagcgtccgt tcccccttct cggtcttcgg ggccgcgaac
     9301 tcgaaggagt acgaacgctc gccggacgcg agcaggtcac gcacggtacg ggcgtgatcc
     9361 gtcctggtgg aggcagtgcc tagggccata ccggtcaagt taaccagcgt ggcgacgatc
     9421 ttcccaagcg gtgtccacga tctggccgtt tcccggcccc gggtgtccgg tacacccttc
     9481 tccgaacctt ccccaaacac cgactttccg gattttcccg gaccggcggg cgagattccg
     9541 gattcccgtc cagacgaatt cgcgtccgct cttcgaagag aatacccccg cgggaatgac
     9601 tcgcgaagcc gcacccactt tccctttctt tcacgaccga cacattccgt cccagtgacc
     9661 gacgcacggg ccacaccgca ctcccgattc ggccatgatt atctgacttg aaatgcgatg
     9721 aatcgttttg gcgtgcctag tatggccata cgccctacgg ccgaaccgga taccgacccg
     9781 ctgccggggc gcctctctcc aagggagcac ggccggccgg acggatttcg gggcgaaaaa
     9841 gggtactccc atcaaaggag acgtcatgaa gaagacgtac gaagctccca ccctggtcaa
     9901 gcgcggcacc ttccgggcca agaccggcct gctccgcacc tcgggcaacg accgtctgat
     9961 cctcagcaag aactgacgac ggccggagac agagggctga atgcctacgc ctcgcgaggc
    10021 ggggggagcg ggcccgggcg ccgcgtcctt cgtggtcctt ccggactgcg acgacgcgct
    10081 caccgcggcc cgctccctca tccgccagga cacccgggac agccaggaca tccaagacat
    10141 ccaggcccct cactacaccc ggaccatccc ccacccctcc ggccggccct ggatcgccgg
    10201 ccgctggcac gacgaggacg tcaccgccgt acgggccggc cgggccgccc tggcggtcat
    10261 cggctgctgc cccgtccggc ccgaggaact ccgccgacgg gcggaggcgc tgcgcgacct
    10321 gaccgccctg gacgccctgg cccgggccct gcccggccgc ttccacctgg tggccgcgct
    10381 ggacggtgcc gtccgcgtcc agggcacggc gtccggtctc cggctcgtcc accgcgccac
    10441 cgtcggcggc gtcgaggtgg ccgcgagcga cgccctgccg ctggcccgcg ccctggactc
    10501 cacgcccgac gaggaggagc tggccgtccg cctgctgtgg ccggtcccgc accccctctt
    10561 cgccacgtcg ccctggcgcg gcgtcaccgc cgtccccgcc gaggacgccc tgtacgtgtc
    10621 ccgcgacggg cgtaccgtcc ggcactcccg ctggtggacg ccgcccgagc cggtgcgctc
    10681 gatggccggc ggcgcgcccc tcgtgcgcca ggcgctcacc gaggccgtgg cggcccgcac
    10741 ccaccggggc tccacggtca gctgcgacct gtccggcggg ctggactcca cctccgtctg
    10801 cttcctggcc gcggcctccc cggcccgggt gatcgcgagc acctggccgg ggcgcgaccc
    10861 cgccgacagc gacctggcct gggcccgccg cgccgcccgc cacctgccgc acgtcgagca
    10921 cgtggtgtgg gacgcggacg agtcgccgct cgtctacacc gacctgctgg acatcgacga
    10981 gccgatggac gagccgacca tcggcgtgat ggaccgggcc cgcgtgcgct gcaccacctc
    11041 ccggagctcg cccgccgcgg cagttcgacg cacctgacgg gcatcggcgg cgaccacgtc
    11101 gcctggtgtt cggagggcta ctaccaccgg ctgctgcgga cgcgcccgtg gttcgcgctg
    11161 cggcagttgc gcggcttccg caccctctac cagtggccgc tcgcgccggc cgtgcgcacg
    11221 ctcgccgact cccgccccta cggccgctgg ctggcgggca cggcggcgcg gctgcgcgat
    11281 ccgctcccgc ccggcgtgga gggggcgctg ggctggggca ccgcgccccg gctgttcccc
    11341 tgggtcaccc ccgaggccgc cgaggccgcc cggcgggccc tgctccgggc cgccgcgacc
    11401 gccgagccgc tccaccgcga ccgcgggctc caccaggacc tggagcagat ccggatctgc
    11461 acccggatcg tccgccagtg ggacctgatg gccgcgcgga cgggcctgcc gacggcgtcg
    11521 ccgttcttcg acgaccgggt gatcgaggcg tgcctggccg tcgacccgcg cgcccgcgtc
    11581 accccctggg cgtacaagcc gctgctgggg gcggcgatgc gcgggatcgt cccggacgcc
    11641 tgcctggccc gcaccgacaa ggcgcacgcc tcgatggacg cctcgaacgg cctgcgggag
    11701 caccggggcg acctggtgaa gctctgggag gactcgtcgc tggcccggct ggggctggtc
    11761 gacgcgggcg agctgaccgc cctcgcccag cggcccgcca cgcccggcct gggcgacgcg
    11821 atcctctact ccacgatcgg ctgcgaggtg tggctccgga ccctcgcccg ctgaccgccc
    11881 accggatcga ccgcggacga cggcgtccgc aggacaggaa gggaaggctc catggcactg
    11941 cggttcgccc cggacgtcgc caccgcggag acggagtacg gcacggtcct gctcgaccag
    12001 cgcaagggcc gctactggga gctcaacccc accggcacgc tcgtcgtccg cacgctgctg
    12061 gacggcggcg gggaggcgga cgcggtggag gcgctcgtcg gcgcgttcgc cgtggaccgg
    12121 gagcgggccg ccgcggacgt cgccgcgctg gtcgcgctgt tgcgggacgc ggggctggcc
    12181 gcatgaccac gcccagcgcc ctggtccggc cgtcggacgt gccgttcccc cggcggctgg
    12241 ccgcccggct cgccctggcc gtcgccttcc cgctggccct gctgccgccg caccggctcc
    12301 gcgcggtcct cgccgtgctc cgccggggtg ccgcccccgc ctcgtacgag cgggccggcg
    12361 cggcgcggcg cgcggtgtgc gcggtcagcc tgtactgcgc ggggccgcgc ggctgcctgc
    12421 cgcggtcgct gggcacggcg ctgctgtgcc ggttcggcgg ctgctggccg acgtggtgca
    12481 ccggcgtgcg caaggtgccg ccgttcagcg cgcacgcctg ggtggaggcg gagggccggc
    12541 cggtggacga gggggtgccg gacgactact tcggccggct gctcaccgtg gcccccggcc
    12601 cgtcgccccg gaagcggccg ctgccgtgac gccggccggg accggacggc gggacgggcc
    12661 gggcgcggtc cgcacggttt tccggctcac cgccggccac cgcgcggcgc tgaccaccgc
    12721 catcgtcctc accctggtgg ggtcggcgct ggggctggcg cagccgctgc tcgcccagcg
    12781 gatcgtggac gcgagcgcgg acggccggcc gctgtggccg ctggtgttcc tggccgtgct
    12841 gttcgcggcc gaggccggca cggcgtcggt gggccgcttc ctccaggagc ggatgggcga
    12901 gggcgtcgtc cgcgggctgc gccaccggct gaccggccgg ctgctgcggc tggagatgcg
    12961 ggagtacgag caccacagga ccggcgacct cgtctcccgc gtcaccgtcg acaccaccgt
    13021 cctgcgcgag gtcctctccc aggcgctggt ggacctggtc accggttcgc tggcgtcggc
    13081 gggggcggtg gccctgatgc tctggctcga cccgctgctg ctgctcctgg tcgccctcac
    13141 ggtggcggcg gcggccgcgg tcgtgaccgg tgtcctcagc gggctccgca cggcctccga
    13201 acggacgcag cacgccgtcg gggccatcgc ggccgacctc gaacgggccc tgggcgccct
    13261 gccgatggtc cgggtgcacc gggcggagga gcgggaggcg gcccggatcg gggagcgggt
    13321 ggacgcggcg tacggcgcgg gggtccgcac cgcgcggctg gcggcggtga tgagcccggc
    13381 ggtcgaactg gccgtccacg gctcgttcct gctcgtcctg gtcatcggcg ggctgcgggt
    13441 ggacgggcgc acgcacagcc tcggcgacct ggtcgccttc ctgctgtacg ccagttatct
    13501 ggtggtgccg ctgtcgtcgg tgttccacgc ggcggggctg ctccagcggg gcgtgggggc
    13561 gctcgggcgg gtggaggagg cgctcgcgct tccggtggaa ccggcggggg cggagccgcc
    13621 cggcccggac gagccgtgcg cacccgctcc ctcccccgtc tctcctgccc cgtcctcccc
    13681 gcccgtcctg gccctggagg acgtccggtt cggctaccgc cccggccggc cggtgctgcg
    13741 cggcgtctcg ctggaggtgc cgccgcaccg gcaggtcgcg ctggtgggca ggtcgggggc
    13801 ggggaagagc acggtcttcg cgctggccgc ccgcttctac gaaccggacg ccggccggct
    13861 gctgttcgac ggccgcccgg ccgccgggat gacccgcgcc gagtgccggg cgcgcatcgc
    13921 cgtcgtcgac cagaacaccc acgtcgtcca cgggtccctg tgggacaaca tcacctacac
    13981 cgcaccgggg gcgagccggg ccgaggtgcg gcgggtggtc gaactcgccc ggctcgacga
    14041 ggtggtggac cggctgccgg gcgggctcga cgggccggtc ggggagcggg gcgcctccct
    14101 gtcgggcggc gagcggcagc gggtcgccct ggcccgggcg ctgctcaccc gccccgcgct
    14161 gctgctgctg gacgaaccca cgtcccagct cgacgcggtc aacgagctgg cgctggggcg
    14221 ggtgatgcgg gagatcaccg aggagtgcgc gctgctggtg atcgcccacc ggctgtccac
    14281 cgtgcagaac gccgaccgca tcgtcgtcct gcacgagggc cgggccgtcg cctccggccg
    14341 gcacgaggac ctgctgtccg gctgtgccgc ctaccgcgag ctggcggcgg cacagatgct
    14401 gcggacgggc tgagggcggg gccgagaggg tcagccgccg agcttcggca ggccgggcag
    14461 cttggcgccg ccgctctgcc gcgcgaaggt ctccttcggc ccgccctccc aggagacgac
    14521 catggaggtg gcgtcggact tctcgatgat tcccctcgtg cgcttgtcgc cgccgtccga
    14581 gcacttgagg gtgagggact tcccgctgac ggtgccggag caggtgcgct tgccgccgtc
    14641 ggacgccagg gccgcctgcc cggcgacgat cgtcagggcg accggtccct cggcggactg
    14701 cgccaggtag gcgcccccgg gagagctgat gagcttgtcc tcggccccgg cgcccttcgc
    14761 gccctcgctc ggagcggcgg actgccccgc cgaccgcgcc ggcttggcct cgtccttctt
    14821 gccgtccttg tcgtcgctcc cgctggagca ccccgtcatc agcacagcgg cgatgagagc
    14881 cgcccccgtg atctgtgccg ccttgcgcac tgcgcgttct ccttcgtcgt gttcgtcgcc
    14941 gtccatgatt gaacgcggac acgacaacct accggaggcg tcagtcgcgc tcgcggatcc
    15001 ggcgggccag ccgggccgcc gcgtcaccgg ggtcgtcggc ctcggtgagg gcgcggacga
    15061 cgacgacgcg ccgggccccg gcgtccagga cctcgtcgag gttgcgctcg tcgatgccgc
    15121 cgatggcgaa ccacggccgc tcgggccgca gcgcggcggt gtgccgcacc agggacaggc
    15181 cgggcgcggg gcggccgggc ttggtgggag tgggccagca ggggccggtg cagaagtagt
    15241 ccacgcccgg ttcgcgcatc gccgcctcgg cctcggcctc gctgtgcgtg gagcggccga
    15301 tcagcacgtc gtcgccgagg acggcgcgcg cggcgggcac gggcaggtcg ccctggccca
    15361 ggtgcaggac gtcggagcgg atggcgtggg cgacgtcggc gcggtcgttc accgcgagca
    15421 gccggccgtg ccggcgggcg gcgtcggcca ggacggccag gtgctccagc tcctcaccgg
    15481 cctccatgcc cttgtcgcgg agctgcacga cgtccacacc gccggcgagg acggcgtcca
    15541 ggaactccgg caggtcgccc tggcgcttgc gggcgtcggt gcacaggtac agccgggcgc
    15601 cggcgagggc ctcccgggcc gtcggggcgt gcgggagcgt acgggcggtg gcggacatcg
    15661 ggtttccccc cggggtcggc ggtgcgcgga cgggacgggc ccgcccgcgc accgcgggct
    15721 gttcactgcg gaacggtcag acggcgagcg cctgggcgcg ccgcttcacc tccgtgccgc
    15781 gattctcccg cagcgcctgc gcgggcgtgc ccggcagggt ggggtccgga gtgaacagcc
    15841 actccagcat ctcctcgtcg gtgaacccgt cgtccttgag cagcgtcagg gtcccggcca
    15901 ggcccttcac caccttgccc tcgccgatga aggcggcggg cacctgcagc acccggttct
    15961 ccccgcggcg cacggcgatc agctggccct ccttcaccaa ctgccgtacg cgcgtcacct
    16021 ccacgtcgag catctcggcg atgtcgggga gggtgagcca ctcggagacg agggcatcga
    16081 tcttcgtgtc aatctcggtc acgggacaag cgtgccatcc tccacggaca gccggtaccc
    16141 ggggacaccc gggggtgtcg cccctccagc ccgtccggcg tttgaggaca accgcgcgga
    16201 gcgcggtttc agggggtccg gggggcttgc cccccgggaa acggcgaaag ggcgggaccg
    16261 gggcccctca ccccaccgcc gacttcagcg gcaccgccgg atcggccacc cgctcccggt
    16321 ccaccaccgc ccccttctcg atcagcttcc gcccctgcgc cagatcccgc ggccgtccca
    16381 ccgccagcac cgccaccagc accccgcccc gcaaccagca caccgtccac gcggcccccg
    16441 ccggatcccc ccgccacacc agctcgtcgg cggcggcatg atgccccgcg tactgcacga
    16501 accgcccgaa ctgctcggac cagaagtagg gcaccgggtc gtagaccggc ccctcggccg
    16561 gcccgtgcac gatgttcgcg gcgacggtct tcggcccctg gagggcgttg tcccagtggt
    16621 ggacgaggag ccgttcgccg taccgcgcgg aggggaagga ggcgcagtcc ccgaccgcgt
    16681 acacgtccgg gacggacgtc cgcagccggt cgtcggtgac gacggagcgg tccgccgcga
    16741 gttcgacgcc cgagccggcc agccagccgg tggcgggccg cgcgccgatg cccacgacga
    16801 cggcgtcggc ggtgagccgg gtgccgtcgg ccagcagcac ggcgccgggc tccagggcgg
    16861 ccacccgggc gccggtgagc agccgggcgc cgctctgccc gtaccagtcg gccatgtgcg
    16921 cggcgacctc ggcgggcagc gcgccggcca gcgggcggtc ggcggcctcg acgacggtca
    16981 cccggcagcc ggcctcgcgg gcggcggtgg cgaactcggc gccgatccag ccggccccga
    17041 cggcgaccac gtcgcccttc cgctccagca gcggacgcag ccgctccgcg tcgtccaggg
    17101 tgcgcagcag atgcacgccg ggcaggtcct cggcaccggg cagccggacc ggctcggcgc
    17161 cggtggccac caccaggacg tcgtacggaa ccgggccgcc cggcgtgtcc acctcgtggt
    17221 cggcgggccg cagcccggtg acctcgagac cgagccggag ctcgatgtcc agcgacgcga
    17281 agtcgacctc gaaggcggac ccgtccgcct tgccgagcag caccgccttg gacagcggcg
    17341 gccggtcgta gggcggatgg ggttcggcgc cgagcagggt gatcgtgccc tcccagccct
    17401 gctcgcggag ggcgacggcg gtctgcacac cggccatgcc ggcgccggcg acgacgacgc
    17461 gccgccgcgc cgcgcccccg gccgtctgct cggaccgctc ggcggccgta ccactgcggg
    17521 tgttcgtctg ctcactcacc cgatcactgt aggcgggcgg acgaggtctc ccggagcacc
    17581 gtgcggcgag acctccgaca caacacggcc gcgccgcgcg cccccggacc ggtccccgcc
    17641 gccttccgcc gcgttcgcgg cccgtactag ggtggccggt gcacaagcac tcgcgggagc
    17701 ccggacggac cgggctgaga gggaggctgg acggcctccg accgtacgaa cctgatccgg
    17761 gtcatgccgg cgaagggagg ggctggacgc ccatgcacgc gtctacgcgc accggaccgt
    17821 acgacgtcct ggtgatcggc ggcgggatca tcggcctggt gaccgcctgg cgggccgccc
    17881 agcggggcct gcggaccgcc gtcgccgacc cgtcgcccgg cggcggggcc gccctggtgg
    17941 cggccgggat gctggccgcc gtcaccgaac tgcactacgg cgagcaggcg ctgctcgccc
    18001 tcaacctggc ctcggcccgc cgctaccccg acttcacggc cgagttggag gaggcgagcg
    18061 gccgggacac cggctatcgc gcctgcggca ccctcgccgt cgccctcgac gccgacgacc
    18121 gcgcccacct gcgcgaactc ggcgcgttcc agcggcgctg cgggctggag gcggagtggc
    18181 tgaccggccg cgagtgccgc cgcctggaac cgatgctcgc cccgggcgtc cagggcggcc
    18241 tgcgggtgga cggtgaccac cagaccgacc cccggcggct ggccgccgcc ctgctgaccg
    18301 cctgcgaacg cgccggcgtg accctgcgcc gcgcggccgt cgcccgggtg ctgctcgacg
    18361 gcgaccgggc cgcgggcgcc gaactcgccg acggggagcg gatcgccgcc ggccagaccg
    18421 tgctggcggc cggcagccac agcgcccggg tggccgggct gcccgacgcc gtcctgccgc
    18481 cggtccgccc ggtgaagggc cagaccctgc ggctgcggat ccccgaggcg taccggccgt
    18541 tcctctcccg caccgtccgc gcggtcgtcc gcggcaaccc cgtctacctg gtcccccggg
    18601 agaacggcga gctggtgatc ggcgcgacca ccgaggagct cggctgggac accaccgtca
    18661 ccgccggcgg cgtctacgaa ctgctgcgcg acgcgcacga gctggtgccc ggcctcaccg
    18721 aactgccgct cgccgagacg tccgccgggc tgcggcccgg ctcccccgac aacgcgcccc
    18781 tcctcggccc gacggacctg cccggcctcc acctggccac cggccaccac cgcaacggcg
    18841 tcctgctgac cccgctcacc ggggacgtca tggccgaagc gctcaccacc gggcggctgc
    18901 ccgaggaggc ccgcccgttc accccccgcc ggttcgccgc cccggccggc ccccgcccgg
    18961 cctcccccgt tcaggagccc tccgcatgac cgacgtccac accgtccacg tcaacggcga
    19021 gcggcgcgcc gtcccgtccg ggacgaccct cgccacgctc gtcgccggcc tcaccggccg
    19081 ccccgactcc ccgggcggcg tggccgccgc cgtcaacgag gccgtcgtcc cgcgcggccg
    19141 ctgggcggac acgcccctgc gcgacggcga ccgcgtcgag gtcctcaccg cggtgcaggg
    19201 aggctgacgt ggcggacgac gtgctcacca tcgccggcac cccgttcacc tcccgcctga
    19261 tcatgggaac gggcggggcg cccagcctcg acgtcctgga acgggccctg ctcgcctccg
    19321 gcaccgaact gaccaccgtc gccatgcgcc gcctcgaccc ggcggtccgc ggctcggtcc
    19381 tgtcggtcct ggagcggcac ggcatccggg tactgcccaa caccgccggc tgcttcaccg
    19441 ccggcgaggc cgtcctcacc gcccggctgg cccgcgaggc gctgggcacc gactgggtga
    19501 agctggaggt catcgccgac gagcggaccc tgctgcccga cccgatcgag ctgctcgacg
    19561 cggcggagat cctcgtcgac gacggcttca ccgttctccc ctacaccaac gacgacccgg
    19621 tcctcgcccg ccgcctggaa gacgtcggct gcgccgcgat catgccgctg ggctccccca
    19681 tcggctccgg cctcggcatc cgcaacccgc acaacttcca gctcatcacc gagcgggcga
    19741 aggtcccggt gatcctggac gcgggcgcgg gcacggcgtc ggacgcggcg ctcgccatgg
    19801 agctcggctg cgcggcggtg atgctcgcgt cggcggtgac gcgcgcccag gagccggtgc
    19861 tgatggcgga ggcgatgcgc cacgcggtcg aggcggggcg cctcgcgcac cgggcgggac
    19921 ggatcccgcg ccgccatttc gcggaggcgt cgtcgccgac ggcgggtatg gcggtgttgg
    19981 atccggaacg gccggcgttc agcgcgcgct gagggggtgg agccccggcc ccgccctttc
    20041 tccgtttctt gcgggggcca gcccccgcac ccccgaaacc gcgctccgcg cggttgtcct
    20101 caaacgccgg acaggctgat attcagcccg tccggcgttt gaggacgagc ggcggagccg
    20161 cgaaaggggg gtctgggggc gcagccccca ggaatcggcg aaggggcggg ccaggggcaa
    20221 ccccaatgtc accgttccgc acccgtagct ccggacggcc ccacgaaagc acagccgacc
    20281 gtcgatcact cgtagactcg tcaaccgtgg atacgaccct gccggacccc ctcgtcgacc
    20341 ggctgctcga cggccgctac cgcattcagg cgcgggtggc cgcaggcggc atggccacgg
    20401 tgtaccgggc tctggacacc cggctcgacc gggtgctcgc cgtgaaggtg atgcaccccg
    20461 ccctcgccgc ggacaaggtc ttcgtcgaac gcttcatccg ggaggccaag tccgcggccc
    20521 gcctggacca cccgaacgtg gtgagcgtct acgaccaggg gacggacggc gggtacgtct
    20581 acctcgcgat ggagtacgtg gccggctgca ccctgcggga cgtgctgcgc gagcggggcg
    20641 cgctccagcc gagggcggcg ctggacatcg cggagccggt gctggccgcg ctgggcgccg
    20701 cccaccgcgc gggcctggtg caccgcgaca tgaagccgga gaacgtgctg atcggcgacg
    20761 acggcagggt gaaggtcgcc gacttcggcc tcgcccgcac cgtgggcacc aacagcgcca
    20821 ccaataccgg ctccatcctg ggtacggtct cctacctcgc ccccgagcag atcgagcacg
    20881 gcacggcgga cacccgcacc gacgtctacg cctgcggcgt cgtcctctac gagatgctca
    20941 ccggcgtcaa gccgcacagc ggcgccagcc cggcccagat cctctaccag cacctgcacc
    21001 gggacgtgcc gccgccgtcg caggaggtcc cggggctggc cccggagctg gacgacctgg
    21061 tgaccgtggc caccgcccgc gatccggagc tgcgcccgtc ggacgcggtc ggcatgctgg
    21121 gcctggtccg ggccgcccgc gcgaccctga cccgcgagca gctggacgcc cggccgccgc
    21181 tggccgcggg tccggccgtg gcgggcgacg acgaggaggc gacgagcgtc ctgccgcgcc
    21241 cggtcaccgc gcagccgctg cccccggcgg aggcgcccga gccggacccg atggacatga
    21301 cggcgcggtt cgacggcccg cccgagcccc cgccgccgcc cgctcccccg gcccgccccc
    21361 ggcgcttcgc cgccctgcgg cggcggccgc ggcgcgcggt gctggtcgtg gccggtgtgc
    21421 tgctggcgct gctggccggg acgggcgtct ggtacatcaa cgccgggcag ttcacctccg
    21481 tcccggcggt gctggacctc acccaggcgc aggcggagaa gaagctggac aaggcggggc
    21541 tcaaggtccg cgtccagccc gagttcagcg acaccgtcga gcgcggccac gtgatgtcga
    21601 ccgaccccaa gcccggcgag cgcatccgga acaccggccg ggtgaccgtc gtcgtctccc
    21661 gcggcccgga gcgggccgag gtccccaacg tcgtcggcat gcggctggac gacgcgaaga
    21721 aacggatcac ccaggcgggc ctgacggtcg gcgacgtccg gacgcagttc agcgacgaga
    21781 ccccgcaggg cgaggtcctc tccagcgacc cccgcggcgg ggacgagcgc cgccccgact
    21841 ccccggtgtc gctgatcgtc agcaagggcg agccggtgga ggtgccggac gtgtccggcc
    21901 tgtcgcccga cgacgcccag tccacgctga gcgacgcggg cctgcggatc agggtctcgg
    21961 acgcgcaggt gtactccgac cgggagaagg gcgacgtcgc cgagcagtcc cccgcccggg
    22021 gcgtgcaggt ggccaagggc gacaccgtga ccgtcaccct gtccaagggc aaggagatgc
    22081 tcaccgtccc ggacgtcacc ggccgcagcg aggccgacgc caagcggatc ctgacctccg
    22141 ccggcttcca ggtccgggtg gaccggccgt tcttcttccc caaggactcc gtggagagcc
    22201 agtccgtccg ggccggcgac aaggccgccc gcggcgacac ggtcaccatc cgcctcaagg
    22261 gagcactgtg atgtccggcg ctgtgacggc gggcataccc cgcaaccccg tcggcggtca
    22321 cgtcccggtg gccggcgggc tggcccgcac cggcctgccg tacgcccgcg agatcggcgc
    22381 cgaggccgtg caggtcttcg tcgccaaccc gcgcggctgg gcgaccccgc ccggcagccc
    22441 gccgcaggac gaggagttcc gcgcgggctg cgcggcggcc ggactgccgg tgtacgtcca
    22501 cgcgccgtac ctgatcaact tcggttccca cacggaggcg accgccgaac ggtccgtgga
    22561 ctccctccgc cactccctcc gccgaggccg ccggatcgga gcccgcggcg tcgtcgtcca
    22621 caccggctc
//
