GCF_017655765.1 - 7 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP040417.1 (Dolosigranulum pigrum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	lanthipeptide-class-ii	153,558	176,056	Low	bovicin HJ50	ribosomal:RiPP:Lanthipeptide
Region 2	RiPP-like	377,287	389,443
Region 3	terpene-precursor	500,465	521,355
Region 4	lanthipeptide-class-ii	1,124,430	1,147,072	High	enterocin W α/enterocin W β	ribosomal:RiPP:Lanthipeptide
Region 5	RiPP-like	1,410,770	1,422,923
Region 6	azole-containing-RiPP	1,821,326	1,849,702
Region 7	lanthipeptide-class-ii	1,875,883	1,903,626

NZ_CP040417.1 - Region 1 - lanthipeptide-class-ii

Download region GenBank file

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Location: 153,558 - 176,056 nt. (total: 22,499 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

FE328_RS00760: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001787.3	0.64	ribosomal	suicin 3908	Streptococcus suis
BGC0000498.5	0.64	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000626.3	0.61	ribosomal	thuricin	Bacillus thuringiensis
BGC0000561.5	0.61	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000548.4	0.51	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000547.5	0.49	ribosomal	salivaricin 9	Streptococcus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001787.3	0.64	ribosomal	suicin 3908	Streptococcus suis
BGC0000498.5	0.64	ribosomal	bovicin HJ50	Streptococcus equinus
BGC0000626.3	0.61	ribosomal	thuricin	Bacillus thuringiensis
BGC0000561.5	0.61	ribosomal	thermophilin 1277	Streptococcus thermophilus
BGC0001210.5	0.52	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000548.4	0.51	ribosomal	salivaricin A	Streptococcus salivarius
BGC0000528.5	0.51	ribosomal	michiganin A	Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.5	0.50	ribosomal	nukacin ISK-1	Staphylococcus warneri
BGC0000521.3	0.49	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000547.5	0.49	ribosomal	salivaricin 9	Streptococcus salivarius

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FE328_RS00760

FE328_RS00745

Leader:

MEQKQSVAIETEQLELVQAVSDERLEVLVGG

Core:

KGPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

Core with dehydrations:

KGPGLLKDhbLDhbKDCysPGDhbVDhaDVCysVNLAVVDhaDhbCysKKCysE

antiSMASH-DB 4.0 matches for FE328_RS00745

100.0%

NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptideNZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide

Lanthipeptides: FE336_RS03450_lanthipeptide

1

KGPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

KGPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

1

KGPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

58.8%

NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

33

G G +KTLTKDCPG +S+VCVN+ +S CK C

2

GSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

33

58.8%

NZ_AQQB01000068.1and 6 others:

NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptideNZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptideNZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptideNZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptideNZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptideNZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide

Lanthipeptides: K738_RS01000000110290_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

33

G GL+KTLTKDCPG +S++CVN+ +S CK C

2

GSGLVKTLTKDCPGFLSNICVNIGFISGCKNC

33

with 44 more sequence matches

Only the first 10 are displayed here.

50.0%

NZ_CP040409.1and 3 others:

NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide

Lanthipeptides: FE336_RS03460_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

GPGL++TLTKDCP V VC + CK C

2

GPGLVRTLTKDCPNVVPKVCFD----GNCKYCR

30

50.0%

NZ_CP040414.1:

Lanthipeptides: FE331_RS04030_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

GPGL++TLTKDCP V VC + CK C

2

GPGLVRTLTKDCPNVVPKVCFD----GKCKYCR

30

50.0%

NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

33

GPG ++TLTKDCP V CV + CKKC

2

GPGWVETLTKDCPWNVPVACVTIMGQRICKKC

33

50.0%

NZ_KB976165.1:

Lanthipeptides: ICC_RS24850_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

GPG ++TLTKDCPG C+ +A + CKKC

2

GPGWVETLTKDCPGYKPYACITIAGQTICKKCR

34

47.1%

NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

33

GPG ++TLTKDCP CV + CKKC

2

GPGWVETLTKDCPWKQPAACVIIMGQKICKKC

33

47.1%

NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

GPG ++TLTKDCP + CV + CKKC

2

GPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

34

47.1%

NZ_CM000758.1and 1 other:

NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide

Lanthipeptides: BTHUR0013_RS15850_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

GPG + TLTKDCP C+ +A + CKKC

2

GPGWIATLTKDCPANKPYACITIAGQTICKKCR

34

47.1%

NZ_CP036053.1and 7 others:

NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptideNZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptideNZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptideNZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptideNZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptideNZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptideNZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide

Lanthipeptides: EXW64_RS27135_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

33

GPG ++TLTKDCP CV + CKKC

2

GPGWVETLTKDCPWKQPGACVIIMGQKICKKC

33

47.1%

NZ_CP036100.1and 1 other:

NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide

Lanthipeptides: EXW47_RS29185_lanthipeptide

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKC

33

GPG ++T+TKDCP V CV + CKKC

2

GPGWVETVTKDCPWNVPVACVTIMGQRICKKC

33

47.1%

NZ_CP058255.1:

Lanthipeptides: HW369_RS18920_lanthipeptide

6

LKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

+ T+TKDCP TVS VCV +S CK C+

2

VPTITKDCPNTVSSVCVTFPFISACKNCD

30

MIBiG 4.0 matches for FE328_RS00745

17.6%

BGC0000563.4 (AEA03263.1):

Lanthipeptide: venezuelin

4

GLLKTLTKDCPG

15

GLL L C G

7

GLLTLLNTVCIG

18

14.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

TLTKDC

13

TLTK+C

20

TLTKEC

25

8.8%

BGC0002144.3 (RCCGEPOP_RS37510):

LAP: phazolicin

28

STCKKCE

34

+TC +C+

1

ATCARCD

7

FE328_RS00755

Leader:

MEKYNDENKKAQKTVEVIKDKELEQMIGG

Core:

VGPGLVRTLTKDCPNVVPKVCFDGNCKYCR

Core with dehydrations:

VGPGLVRDhbLDhbKDCysPNVVPKVCysFDGNCysKYCysR

antiSMASH-DB 4.0 matches for FE328_RS00755

100.0%

NZ_CP040409.1and 3 others:

NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide

Lanthipeptides: FE336_RS03460_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVCFDGNCKYCR

30

VGPGLVRTLTKDCPNVVPKVCFDGNCKYCR

1

VGPGLVRTLTKDCPNVVPKVCFDGNCKYCR

30

96.7%

NZ_CP040414.1:

Lanthipeptides: FE331_RS04030_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVCFDGNCKYCR

30

VGPGLVRTLTKDCPNVVPKVCFDG CKYCR

1

VGPGLVRTLTKDCPNVVPKVCFDGKCKYCR

30

50.0%

NZ_CM000748.1and 1 other:

NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide

Lanthipeptides: BTHUR0003_RS30910_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVCF----DGNCKYCR

30

+GPG V TLTKDCP +P C CK CR

1

IGPGWVETLTKDCPWNMPVACVTIMGQRICKKCR

34

with 36 more sequence matches

Only the first 10 are displayed here.

50.0%

NZ_CM000758.1and 1 other:

NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide

Lanthipeptides: BTHUR0013_RS15850_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVCF----DGNCKYCR

30

VGPG + TLTKDCP P C CK CR

1

VGPGWIATLTKDCPANKPYACITIAGQTICKKCR

34

50.0%

NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptideNZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptideNZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptideNZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide

Lanthipeptides: FE336_RS03450_lanthipeptide

2

GPGLVRTLTKDCPNVVPKVCFD----GNCKYCR

30

GPGL++TLTKDCP V VC + CK C

2

GPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE

34

50.0%

NZ_CP058255.1:

Lanthipeptides: HW369_RS18920_lanthipeptide

6

VRTLTKDCPNVVPKVC----FDGNCKYC

29

V T+TKDCPN V VC F CK C

2

VPTITKDCPNTVSSVCVTFPFISACKNC

29

50.0%

NZ_KB976165.1:

Lanthipeptides: ICC_RS24850_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVCF----DGNCKYCR

30

+GPG V TLTKDCP P C CK CR

1

IGPGWVETLTKDCPGYKPYACITIAGQTICKKCR

34

48.5%

NC_017621.1and 16 others:

NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptideNZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptideNZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptideNZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptideNZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptideNZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptideNZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptideNZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptideNZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptideNZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptideNZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptideNZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptideNZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptideNZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptideNZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptideNZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide

Lanthipeptides: SSUD12_RS06540_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVC----FDGNCKYC

29

G G V+TLTKDCP + VC F CK C

1

AGSGFVKTLTKDCPGFLSNVCVNIGFISGCKNC

33

48.5%

NZ_AQQB01000068.1and 6 others:

NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptideNZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptideNZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptideNZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptideNZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptideNZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide

Lanthipeptides: K738_RS01000000110290_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVC----FDGNCKYC

29

G GLV+TLTKDCP + +C F CK C

1

AGSGLVKTLTKDCPGFLSNICVNIGFISGCKNC

33

41.2%

NZ_FNYB01000007.1and 1 other:

NZ_KB976303.1 Lanthipeptides: IGY_RS28100_lanthipeptide

Lanthipeptides: BMZ34_RS15340_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVCFDGN

25

+GPG + TLTKDCP V P++C N

1

IGPGYIETLTKDCPRVTPQICVPIN

25

41.2%

NZ_JH792312.1and 1 other:

NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide

Lanthipeptides: IIG_RS24665_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVC

21

GPG V TLTKDCP VP C

1

AGPGWVETLTKDCPWNVPVAC

21

38.2%

NZ_CM000731.1and 2 others:

NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptideNZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide

Lanthipeptides: BCERE0020_RS28875_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVC

21

GPG V TLTKDCP P C

1

AGPGWVETLTKDCPWKQPAAC

21

38.2%

NZ_CP036053.1and 7 others:

NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptideNZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptideNZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptideNZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptideNZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptideNZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptideNZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide

Lanthipeptides: EXW64_RS27135_lanthipeptide

1

VGPGLVRTLTKDCPNVVPKVC

21

GPG V TLTKDCP P C

1

AGPGWVETLTKDCPWKQPGAC

21

MIBiG 4.0 matches for FE328_RS00755

16.7%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

8

TLTKDC

13

TLTK+C

20

TLTKEC

25

5.9%

BGC0002120.3 (NQE92413.1):

Lanthipeptide: nocathioamide A

15

NVVPKVCFD

23

N++ FD

21

NIIDSSMFD

29

allorf_0172499_0172609

Leader:

MIGGGRKMTFG

Core:

VYGSCALNDCLIYSCIALNWGVNWG

Core with dehydrations:

VYGDhaCysALNDCysLIYDhaCysIALNWGVNWG

antiSMASH-DB 4.0 matches for allorf_0172499_0172609

100.0%

NZ_CP040409.1and 4 others:

NZ_CP040414.1 Lanthipeptides: allorf_0825879_0825989_lanthipeptideNZ_CP040415.1 Lanthipeptides: allorf_0731332_0731442_lanthipeptideNZ_CP040417.1 Lanthipeptides: allorf_0172499_0172609_lanthipeptideNZ_CP040424.1 Lanthipeptides: allorf_0727752_0727862_lanthipeptide

Lanthipeptides: allorf_0745435_0745545_lanthipeptide

1

VYGSCALNDCLIYSCIALNWGVNWG

25

VYGSCALNDCLIYSCIALNWGVNWG

1

VYGSCALNDCLIYSCIALNWGVNWG

25

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.44 out of 18.16

Confidence: strong

Additional weak hits (2):

HipB

Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 25.02 out of 33.14

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FE328_RS00745 - Class II

Cleavage pHMM score: 0.20

RODEO score: 0

Monoisotopic mass: 3397.8 Da

Molecular weight: 3400.0 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3418.1 Da N = 1; 3436.1 Da N = 2

FE328_RS00755 - Class II

Cleavage pHMM score: 4.30

RODEO score: 0

Monoisotopic mass: 3244.6 Da

Molecular weight: 3246.8 Da

Number of bridges: 2

allorf_0172499_0172609 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 2697.2 Da

Molecular weight: 2699.1 Da

Number of bridges: 2

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator

NZ_CP040417.1 - Region 2 - RiPP-like

Download region GenBank file

Download region SVG

Location: 377,287 - 389,443 nt. (total: 12,157 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: deacetylase

FE328_RS09365: polysaccharide deacetylase

smcogs: SMCOG1235: polysaccharide deacetylase

Ligases: synthase

FE328_RS01705: pseudouridine synthase

smcogs: SMCOG1279: pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002577.2	0.40	ribosomal	lactococcin G	Lactococcus lactis
BGC0000590.5	0.40	ribosomal	microcin N	Escherichia coli
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001887.3	0.40	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001861.4	0.39	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0000484.5	0.39	ribosomal	glycocin F	Lactobacillus plantarum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0000558.5	0.43	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0001555.4	0.41	ribosomal	colicin V	Escherichia coli chi7122
BGC0002577.2	0.40	ribosomal	lactococcin G	Lactococcus lactis
BGC0000590.5	0.40	ribosomal	microcin N	Escherichia coli
BGC0002674.2	0.40	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0001887.3	0.40	ribosomal	huazacin	Bacillus thuringiensis serovar huazhongensis BGSC 4BD1
BGC0001861.4	0.39	ribosomal	bacillicin BAG2O	Bacillus cereus BAG2O-1
BGC0000484.5	0.39	ribosomal	glycocin F	Lactobacillus plantarum

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.64 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description

NZ_CP040417.1 - Region 3 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 500,465 - 521,355 nt. (total: 20,891 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FE328_RS02280: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Hydrolases: peptidase

FE328_RS02325: methionine aminopeptidase

smcogs: SMCOG1172: methionine aminopeptidase

Ligases: synthetase

FE328_RS02295: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001456.3	0.36	terpene	isorenieratene	Streptomyces argillaceus
BGC0001605.3	0.35	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000665.5	0.35	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000639.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC260
BGC0000641.3	0.38	terpene	carotenoid	Enterobacteriaceae bacterium DC416
BGC0000642.3	0.37	terpene	carotenoid	Enterobacteriaceae bacterium DC413
BGC0001456.3	0.36	terpene	isorenieratene	Streptomyces argillaceus
BGC0001605.3	0.35	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000665.5	0.35	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0000527.5	0.34	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

FE328_RS02295: PT_FPPS_like

Domain 1 (29 - 276): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26

Confidence: medium

Additional weak hits (2):

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 30.11

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.23 out of 30.11

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein

NZ_CP040417.1 - Region 4 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,124,430 - 1,147,072 nt. (total: 22,643 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Hydrolases: protease

FE328_RS05280: alkaline serine protease, subtilase family

smcogs: SMCOG1075: alkaline serine protease, subtilase family

Lyases: cyclase

FE328_RS05320: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

FE328_RS05330: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

FE328_RS05335: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000505.3	0.94	ribosomal	enterocin W α, enterocin W β	Enterococcus faecalis
BGC0000623.3	0.66	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0000500.5	0.49	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000588.5	0.48	ribosomal	microcin L	Escherichia coli

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000505.3	0.94	ribosomal	enterocin W α, enterocin W β	Enterococcus faecalis
BGC0000623.3	0.66	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0000525.5	0.53	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0001555.4	0.51	ribosomal	colicin V	Escherichia coli chi7122
BGC0002698.2	0.51	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000504.5	0.51	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0001210.5	0.50	ribosomal	pseudomycoicidin	Bacillus pseudomycoides DSM 12442
BGC0000622.5	0.50	ribosomal	megacin	Bacillus megaterium
BGC0000500.5	0.49	ribosomal	carnolysin A1, carnolysin A2	Carnobacterium maltaromaticum
BGC0000588.5	0.48	ribosomal	microcin L	Escherichia coli

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FE328_RS05320

FE328_RS05340

Leader:

MTELNKRLQLKRDVSTENSLKKISNTDEIHGG

Core:

VTTSIPCTVMVSAAVCPTLVCSNKCGGRG

Core with dehydrations:

VDhbDhbDhaIPCysDhbVMVDhaAAVCysPDhbLVCysDhaNKCysGGRG

antiSMASH-DB 4.0 matches for FE328_RS05340

100.0%

NZ_CP040417.1and 2 others:

NZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptideNZ_SIYN01000015.1 Lanthipeptides: EY674_RS12755_lanthipeptide

Lanthipeptides: FE328_RS05340_lanthipeptide

1

VTTSIPCTVMVSAAVCPTLVCSNKCGGRG

29

VTTSIPCTVMVSAAVCPTLVCSNKCGGRG

1

VTTSIPCTVMVSAAVCPTLVCSNKCGGRG

29

82.8%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02455_lanthipeptide

Lanthipeptides: B5772_RS02455_lanthipeptide

1

VTTSIPCTVMVSAAVCPTLVCSNKCGGRG

29

+TTSIPC VM S A+CPTLVCSNKCGGRG

1

ITTSIPCAVMASTAICPTLVCSNKCGGRG

29

62.1%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS21840_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06730_lanthipeptide

Lanthipeptides: BKP57_RS21840_lanthipeptide

2

TTSIPCTVMVSAAVCPTLVCSNKCGGRG

29

TT++PC V S A+CPTL CS+KCG RG

1

TTTVPCAVAASIALCPTLACSSKCGERG

28

with 97 more sequence matches

Only the first 10 are displayed here.

42.4%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21840_lanthipeptide

Lanthipeptides: CN325_RS21840_lanthipeptide

2

TTSIPC----TVMVSAAVCPTLVCSNKCGGRG

29

+T++PC T+ +S A CPT C+ +CG RG

2

STTVPCGIGSTITISIAYCPTSKCTERCGTRG

33

41.4%

NZ_LT630004.1:

Lanthipeptides: BQ5796_RS18310_lanthipeptide

2

TTSIPC---TVMVSAAVCPTLVCSNKC

25

TT++PC TV +S ++CPT C+++C

1

TTTLPCVGITVTISVSMCPTTKCTSQC

27

37.9%

NZ_CP025249.1and 1 other:

NZ_CP025249.1 Lanthipeptides: CWT12_RS00390_lanthipeptide

Lanthipeptides: CWT12_RS00390_lanthipeptide

3

TSIPCTVMVSAAVCPTLVCSNKC

25

+S PC + ++ VCPT CS+KC

5

SSWPCGIGITTTVCPTAACSSKC

27

36.7%

NZ_FOBE01000018.1:

Lanthipeptides: BMW61_RS21935_lanthipeptide

1

VTTSIPCTVMVSAAVCPTLVCSNKC

25

V ++P T+ S A CP++ CS+KC

6

VPITVPITIAASTAFCPSIKCSSKC

30

36.7%

NZ_MJEJ02000054.1and 3 others:

NZ_MJEJ02000054.1 Lanthipeptides: BH683_RS28810_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptideNZ_QJSP01000005.1 Lanthipeptides: DFR67_RS30760_lanthipeptide

Lanthipeptides: BH683_RS28810_lanthipeptide

3

TSIPCTVMVSAAVCPTLVCSNKCGGRG

29

T+I +S A+CPT C+ GG G

4

TTISLASALSVALCPTFKCTGVDGGCG

30

36.4%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07810_lanthipeptide

Lanthipeptides: NW953_RS00175_lanthipeptide

9

VMVSAAVCPTLVCSNKCGGR

28

V S A CPTL CS++CG R

12

VAASTAQCPTLACSSRCGKR

31

35.5%

NC_018499.1and 5 others:

NC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27845_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27840_lanthipeptideNC_018499.1 Lanthipeptides: BCK_RS27835_lanthipeptide

Lanthipeptides: BCK_RS27845_lanthipeptide

2

TTSIPCTVMVSAAVCPTLVCSNKC

25

T + P V VS +CPT C++KC

8

TPATPTIVAVSLGICPTTKCTSKC

31

35.5%

NZ_AP026714.1and 21 others:

NZ_AP026714.1 Lanthipeptides: PO853_RS06520_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP028724.1 Lanthipeptides: C7I31_RS11270_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_CP092907.1 Lanthipeptides: MK744_RS03990_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KB944759.1 Lanthipeptides: WOA_RS09815_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845892.1 Lanthipeptides: EB42_RS00090_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_KZ845958.1 Lanthipeptides: EB53_RS07695_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607361.1 Lanthipeptides: FN738_RS03740_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LR607378.1 Lanthipeptides: FN751_RS00125_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_LSFS01000007.1 Lanthipeptides: AW733_RS07745_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMP01000002.1 Lanthipeptides: A5830_RS04680_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptideNZ_NGMV01000001.1 Lanthipeptides: A5824_RS07985_lanthipeptide

Lanthipeptides: PO853_RS06520_lanthipeptide

2

TTSIPCTVMVSAAV----CPTLVCSNKC

25

T +IP ++ VS + CPT VC+ C

4

TITIPISIAVSGWISDKTCPTSVCTRAC

31

35.5%

NZ_MLKL01000042.1:

Lanthipeptides: BKK45_RS27405_lanthipeptide

2

TTSIPCTVMVSAAVCPTLVCSNKC

25

T + P V VS +CPT VC+ C

8

TPATPTIVAVSVKLCPTGVCTKSC

31

35.3%

NZ_JACSPO010000013.1and 1 other:

NZ_JACSPO010000013.1 Lanthipeptides: H9624_RS14885_lanthipeptide

Lanthipeptides: H9624_RS14885_lanthipeptide

2

TTSIPCTV-----MVSAAV---CPTLVCSNKC

25

TT++PC + +SAA+ CPT C+ +C

3

TTTVPCAIGGGVIAISAALPDFCPTGACTTRC

34

MIBiG 4.0 matches for FE328_RS05340

27.0%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

9

VMVSAAVCPTLVCSNKC

25

V VSAA CPT C+++C

21

VGVSAAFCPTTKCTSRC

37

20.7%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

15

VCPTLVCSNKC

25

CPT C++KC

16

FCPTTKCTSKC

26

FE328_RS05345

Leader:

MKKEELVGT

Core:

AKEDFLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCNA

Core with dehydrations:

AKEDFLNVICysENDNKLENDhaGAKCysPWWNLDhaCysHLGNDGKICysDhbYDhaHECysDhbAGCysNA

antiSMASH-DB 4.0 matches for FE328_RS05345

100.0%

NZ_CP040417.1:

Lanthipeptides: FE328_RS05345_lanthipeptide

1

AKEDFLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCNA

51

AKEDFLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCNA

1

AKEDFLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCNA

51

96.1%

NZ_CP040938.1and 1 other:

NZ_CP040938.1 Lanthipeptides: B5772_RS02450_lanthipeptide

Lanthipeptides: B5772_RS02450_lanthipeptide

1

AKEDFLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCNA

51

AKE+FLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCN

1

AKENFLNVICENDNKLENSGAKCPWWNLSCHLGNDGKICTYSHECTAGCNV

51

52.9%

NZ_CP017762.1and 3 others:

NZ_CP017762.1 Lanthipeptides: BKP57_RS02100_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptideNZ_CP073011.1 Lanthipeptides: KBP50_RS06725_lanthipeptide

Lanthipeptides: BKP57_RS02100_lanthipeptide

22

KCPWWNLSCHLGNDGKICTYSHECTAGCNA

51

KCPW+NLSCHLGNDGKICT+SHECT GCNA

1

KCPWYNLSCHLGNDGKICTFSHECTGGCNA

30

with 89 more sequence matches

Only the first 10 are displayed here.

47.1%

NZ_CP102975.1and 1 other:

NZ_FMOE01000002.1 Lanthipeptides: BJT27_RS07805_lanthipeptide

Lanthipeptides: NW953_RS00170_lanthipeptide

21

AKCPWWNLSCHLGNDGKICTYSHECTAGCN

50

KC WWNLSCHLGN+GK+CT SHEC AGCN

1

GKCSWWNLSCHLGNNGKLCTVSHECAAGCN

30

39.2%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21845_lanthipeptide

Lanthipeptides: CN325_RS21845_lanthipeptide

23

CPWWNLSCHLGNDGKICTYSHECTAGCN

50

C WWN+SCHLGNDGK CT S EC CN

2

CSWWNVSCHLGNDGKYCTASKECMPTCN

29

35.3%

NZ_CP036016.1:

Lanthipeptides: allorf_075467_075682_lanthipeptide

23

CPWWNLSCHLGNDGKICTYSHECTAGC

49

C WW+LSCHLGNDG CT S EC C

2

CTWWDLSCHLGNDGSTCTLSVECRPAC

28

33.3%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06310_lanthipeptide

Lanthipeptides: EG886_RS06310_lanthipeptide

23

CPWWNLSCHLGNDGKICTYSHECTAGCN

50

C WWN+SCHLGN G+ CT + EC CN

1

CDWWNISCHLGNTGQFCTLTKECQPSCN

28

33.3%

NZ_CP034118.1and 1 other:

NZ_CP034118.1 Lanthipeptides: EG886_RS06305_lanthipeptide

Lanthipeptides: EG886_RS06305_lanthipeptide

23

CPWWNLSCHLGNDGKICTYSHECTAGCN

50

C WWN+SCHLGN G+ CT + EC CN

1

CDWWNISCHLGNTGRFCTLTKECQPNCN

28

31.4%

NZ_NTSF01000026.1and 1 other:

NZ_NTSF01000026.1 Lanthipeptides: CN325_RS21835_lanthipeptide

Lanthipeptides: CN325_RS21835_lanthipeptide

23

CPWWNLSCHLGNDGKICTYSHECTAGC

49

C +WN+SCHLGNDG +CT + EC C

2

CNFWNISCHLGNDGSVCTLTKECRPAC

28

31.4%

NZ_QORY01000016.1and 1 other:

NZ_QORY01000016.1 Lanthipeptides: DT250_RS18255_lanthipeptide

Lanthipeptides: DT250_RS18255_lanthipeptide

28

LSCHLGNDGKICTYSHECTAGCN

50

+S LGN G+ICTY+ ECTAGCN

15

MSKILGNKGRICTYTLECTAGCN

37

29.4%

NC_002570.2and 3 others:

NC_002570.2 Lanthipeptides: AYT26_RS02480_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptideNZ_CP040441.1 Lanthipeptides: FED51_RS02600_lanthipeptide

Lanthipeptides: AYT26_RS02480_lanthipeptide

23

CPWWNLSCHLGNDGKICTYSHECTAGCN

50

C W+N+SC LGN G CT + EC CN

5

CAWYNISCRLGNKGAYCTLTVECMPSCN

32

29.4%

NZ_JACHKG010000014.1and 1 other:

NZ_JACHKG010000014.1 Lanthipeptides: allorf_027480_027638_lanthipeptide

Lanthipeptides: allorf_027480_027638_lanthipeptide

20

GAKCPWW------NLSC-----HLGNDGKICTYSHECTAGCN

50

GA P W +L+C +GN G +CT + EC CN

1

GAAQPQWAEVIITSLACAAASYFMGNPGHVCTLTVECQKSCN

42

29.4%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS01720_lanthipeptide

Lanthipeptides: EL241_RS01720_lanthipeptide

25

WWNLSCHLGNDGKICTYSHECTAGCN

50

WWN+S +LGN G+ICT + EC + CN

1

WWNVSKNLGNKGRICTLTKECQSMCN

26

MIBiG 4.0 matches for FE328_RS05345

29.4%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

23

CPWWNLSCHLGNDGKICTYSHECTAGCN

50

C W+N+SC LGN G CT + EC CN

1

CAWYNISCRLGNKGAYCTLTVECMPSCN

28

23.5%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

26

WNLSCHLGNDGKICTYSHECTAGCN

50

++LS LGN+G CT + EC CN

6

FSLSNALGNNGGWCTLTKECQPNCN

30

13.7%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

39

CTYSHECTAGCN

50

CT S EC CN

28

CTLSKECQPNCN

39

with 2 more sequence matches

7.8%

BGC0000503.5 (cinA):

Lanthipeptide: cinnamycin

29

SCHLGNDGKIC

39

SC G +C

4

SCSFGPFTFVC

14

7.8%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

45

CTAGCN

50

CT GC

7

CTPGCK

12

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.46 out of 29.25

Confidence: medium

AbrC3

Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 15.51 out of 18.16

Confidence: strong

Additional weak hits (2):

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.36 out of 20.01

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 22.89 out of 29.38

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FE328_RS05340 - Class II

Cleavage pHMM score: -0.00

RODEO score: 0

Monoisotopic mass: 2727.4 Da

Molecular weight: 2729.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 2747.3 Da N = 1; 2765.3 Da N = 2; 2783.3 Da N = 3

FE328_RS05345 - Class II

Cleavage pHMM score: -6.80

RODEO score: 0

Monoisotopic mass: 5524.5 Da

Molecular weight: 5528.1 Da

Number of bridges: 5

TFBS definitions

Regulator	Description
AbrC3	Antibiotic production activator
SypG	Regulator of biofilm formation and host colonization

NZ_CP040417.1 - Region 5 - RiPP-like

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Location: 1,410,770 - 1,422,923 nt. (total: 12,154 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

No tailoring functions detected.

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001555.4	0.48	ribosomal	colicin V	Escherichia coli chi7122
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.45	ribosomal	microcin L	Escherichia coli
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000558.5	0.48	ribosomal	sublancin 168	Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2	0.48	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0001555.4	0.48	ribosomal	colicin V	Escherichia coli chi7122
BGC0002674.2	0.46	ribosomal	enterocin F4-9	Enterococcus faecalis
BGC0000590.5	0.46	ribosomal	microcin N	Escherichia coli
BGC0000588.5	0.45	ribosomal	microcin L	Escherichia coli
BGC0001862.4	0.45	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000617.5	0.44	ribosomal	coagulin	Bacillus coagulans
BGC0000504.5	0.43	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0002306.2	0.43	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ArcA

Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.05 out of 21.55

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 23.16 out of 29.25

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
ArcA	Repressor of carbon oxidation
SypG	Regulator of biofilm formation and host colonization

NZ_CP040417.1 - Region 6 - azole-containing-RiPP

Download region GenBank file

Download region SVG

Location: 1,821,326 - 1,849,702 nt. (total: 28,377 nt) Show pHMM detection rules used

azole-containing-RiPP: ((YcaO or TIGR03604) and (((thio_amide and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or thiostrepton or TIGR03602)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Azole RiPPs

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FE328_RS08775: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: aminotransferase

FE328_RS08770: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000607.5	0.49	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001146.5	0.48	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000605.5	0.48	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000569.5	0.46	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.46	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000628.4	0.46	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03
BGC0000541.5	0.46	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001145.5	0.45	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.45	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000564.5	0.44	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000607.5	0.49	ribosomal	micrococcin P1	Macrococcus caseolyticus
BGC0001146.5	0.48	ribosomal	cyclothiazomycin C	Streptomyces sp. NRRL WC-3908
BGC0000605.5	0.48	ribosomal	GE37468	Streptomyces sp. ATCC 55365
BGC0000569.5	0.46	ribosomal	plantazolicin	Bacillus velezensis FZB42
BGC0001173.5	0.46	ribosomal	plantazolicin	Bacillus pumilus ATCC 7061
BGC0000628.4	0.46	ribosomal	lactocillin	Lactobacillus paragasseri JV-V03
BGC0000541.5	0.46	ribosomal	paenicidin A	Paenibacillus polymyxa
BGC0001145.5	0.45	ribosomal	cyclothiazomycin b1	Streptomyces mobaraensis NBRC 13819 = DSM 40847
BGC0000603.5	0.45	ribosomal	cyclothiazomycin	Streptomyces hygroscopicus
BGC0000564.5	0.44	ribosomal	clostridiolysin S	Clostridium botulinum A str. ATCC 3502

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 22.36 out of 26.85

Confidence: medium

Additional weak hits (2):

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 26.18 out of 36.54

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 19.72 out of 32.38

Confidence: weak

(Thi)azol(in)e containing peptide predictions

No core peptides found.

TFBS Finder

Azole RiPPs

TFBS definitions

Regulator	Description
RutR	Regulator of the pyrimidine and purine metabolism

Core peptide predictions

No core peptides found.

NZ_CP040417.1 - Region 7 - lanthipeptide-class-ii

Download region GenBank file

Download region SVG

Location: 1,875,883 - 1,903,626 nt. (total: 27,744 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

FE328_RS09080: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Lyases: cyclase

FE328_RS09045: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

FE328_RS09055: lanthionine synthetase C family protein

smcogs: SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.55	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000521.3	0.53	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000552.3	0.52	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000527.5	0.50	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000517.4	0.49	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.48	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000504.5	0.48	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000554.4	0.55	ribosomal	SRO15-3108	Streptomyces filamentosus NRRL 15998
BGC0000521.3	0.53	ribosomal	lacticin 481	Lactococcus lactis subsp. lactis
BGC0000552.3	0.52	ribosomal	SmbA, SmbB	Streptococcus mutans
BGC0001391.3	0.51	ribosomal	thusin	Bacillus thuringiensis serovar rongseni
BGC0000525.5	0.50	ribosomal	lichenicidin VK21 A1, lichenicidin VK21 A2	Bacillus licheniformis
BGC0000527.5	0.50	ribosomal	mersacidin	Bacillus sp. HIL-Y85/54728
BGC0002698.2	0.50	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000517.4	0.49	ribosomal	haloduracin β, haloduracin α	Bacillus halodurans C-125
BGC0002110.3	0.48	ribosomal	birimositide	Streptomyces rimosus subsp. rimosus WC-3908
BGC0000504.5	0.48	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for FE328_RS09045

FE328_RS09035

Leader:

MKQSDKDTVQGNKEHLVEKNFKIYDEVTDEDLQENGG

Core:

VAWTSLVPISLAICPSTKCASITRPCNK

Core with dehydrations:

VAWDhbDhaLVPIDhaLAICysPDhaDhbKCysADhaIDhbRPCysNK

antiSMASH-DB 4.0 matches for FE328_RS09035

100.0%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide

Lanthipeptides: FE328_RS09035_lanthipeptide

1

VAWTSLVPISLAICPSTKCASITRPCNK

28

VAWTSLVPISLAICPSTKCASITRPCNK

1

VAWTSLVPISLAICPSTKCASITRPCNK

28

56.7%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCN

27

WT ++PISLA CP+T+CASI PCN

5

WTIIIPISLAACPTTRCASIVSPCN

29

53.3%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCN

27

WT ++PISLA CP+T+CASI CN

5

WTIIIPISLAACPTTRCASIVSSCN

29

with 64 more sequence matches

Only the first 10 are displayed here.

53.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCNK

28

WT +PISLA CP+T+CASI PCN

7

WTVTIPISLAACPTTQCASIVSPCND

32

51.4%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

3

WTSL---VPISLAICPSTKCASITRPCN

27

WT L +PISLA CP+TKCASI PC

7

WTPLTVTIPISLAGCPTTKCASIVSPCK

34

50.0%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

4

TSLVPISLAICPSTKCASITRPCNK

28

T +PIS AICP+T+CASI RPCN

9

TVTIPISAAICPTTQCASIVRPCNN

33

45.5%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

5

SLVPISLAICPSTKCASITRPCN

27

+++P+SLAICP+TKCAS+ +PCN

10

TIIPVSLAICPTTKCASVVKPCN

32

45.5%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

5

SLVPISLAICPSTKCASITRPCNK

28

+++P+SLAICP+TKCAS+ +PCN

10

TIIPVSLAICPTTKCASVVKPCND

33

44.1%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide

Lanthipeptides: BK581_RS20095_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCN

27

WT +PIS A CP+T+CAS+ +PCN

9

WTITIPISAAACPTTQCASVVKPCN

33

42.9%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

3

WTSLVPISLAICPSTKCASITR

24

WT VP+S+A+CP+ KC S R

3

WTVTVPLSIALCPTAKCTSKCR

24

41.2%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

5

SLVPISLAICPSTKCASITRPCN

27

+++P+SLAICP+T+CASI CN

11

TIIPVSLAICPTTRCASIVESCN

33

38.9%

NC_023073.1and 147 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

10

SLAICPSTKCASITRPCNK

28

SLA CP+TKCASI PCN

18

SLAGCPTTKCASIVSPCND

36

36.8%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

4

TSLVPISLAICPSTKCASITRPCNK

28

T +PIS CP+TKCAS+ PCN

14

TVTIPISAWGCPTTKCASVVEPCND

38

MIBiG 4.0 matches for FE328_RS09035

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

VPISLAICPSTKCAS

21

V +S A CP+TKC S

21

VGVSAAFCPTTKCTS

35

21.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

13

ICPSTKCAS

21

CP+TKC S

16

FCPTTKCTS

24

10.7%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

9

ISLAIC

14

+SL +C

5

VSLLVC

10

FE328_RS09040

Leader:

MNKDFDKELLNISGNLKEELSEADLEQISGA

Core:

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

Core with dehydrations:

GVGKWIRKLDhaKGNDhbGKVCysDhbLDhbWECysGICysPDhaHDhbCysFL

antiSMASH-DB 4.0 matches for FE328_RS09040

100.0%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

34

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

34

61.8%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

6

IRKLSKGNTGKVCTLTWECGICPSHTCF

33

++ LS+GN GKVCTLTWECG+CP+HTCF

3

VQGLSQGNDGKVCTLTWECGLCPTHTCF

30

58.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

3

GKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

G R +S+GN GK+CTLTWECG+CP+HTC+

2

GAEQRGISQGNDGKLCTLTWECGLCPTHTCW

32

with 99 more sequence matches

Only the first 10 are displayed here.

57.9%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

G G R +S+GN GK+CTLTWECG+CP+HTCF

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCF

37

55.9%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

+K+SKGN GK CTLTWEC ICP+ TC+

4

KKISKGNDGKWCTLTWECSICPTKTCW

30

55.3%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

G G R +S+GN GK+CTLTWECG+CP+HTC+

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

52.9%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R LS+GN G CT+TWECG+CP+HTC+

6

RGLSQGNDGDYCTITWECGMCPTHTCW

32

52.9%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R +S+GN GK CTLTWEC +CP+ TCF

4

RGISQGNDGKYCTLTWECSVCPTLTCF

30

50.0%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

9

LSKGNTGKVCTLTWECGICPSHTCF

33

+S+GN GK CT+TWEC ICP+HTC+

7

ISQGNDGKYCTITWECSICPTHTCW

31

50.0%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R +S+GN G CT+TWEC ICP+HTC+

4

RGISQGNDGHQCTITWECSICPTHTCW

30

50.0%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

9

LSKGNTGKVCTLTWECGICPSHTCF

33

+S+ N GK CTLTWEC ICP+HTC+

7

ISEDNDGKYCTLTWECSICPTHTCW

31

50.0%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R +S+GN G CT+TWECG+CP+HTC+

6

RGISQGNDGDYCTITWECGMCPTHTCW

32

50.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

6

IRKLSKGNTGKVCTLTWECGICPSHTCF

33

++ +S+GN GK CT+TWEC ICP+HTC+

3

VQGISQGNDGKYCTITWECSICPTHTCW

30

MIBiG 4.0 matches for FE328_RS09040

26.5%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

12

GNTGKVCTLTWEC

24

GN G CTLT EC

11

GNKGAYCTLTVEC

23

26.5%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

12

GNTGKVCTLTWEC

24

GN G CTLT EC

13

GNNGGWCTLTKEC

25

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTLTWEC

24

CTL+ EC

28

CTLSKEC

34

allorf_1876713_1876829

Leader:

MIHLLHIYCHVRTLSNAPFG

Core:

YYTIHLFLSLFIYRCLKS

Core with dehydrations:

YYDhbIHLFLDhaLFIYRCysLKDha

antiSMASH-DB 4.0 matches for allorf_1876713_1876829

100.0%

NZ_CP040417.1and 1 other:

NZ_CP040421.1 Lanthipeptides: allorf_0553117_0553233_lanthipeptide

Lanthipeptides: allorf_1876713_1876829_lanthipeptide

1

YYTIHLFLSLFIYRCLKS

18

YYTIHLFLSLFIYRCLKS

1

YYTIHLFLSLFIYRCLKS

18

Lanthipeptide(s) for FE328_RS09055

FE328_RS09035

Leader:

MKQSDKDTVQGNKEHLVEKNFKIYDEVTDEDLQENGG

Core:

VAWTSLVPISLAICPSTKCASITRPCNK

Core with dehydrations:

VAWDhbDhaLVPIDhaLAICysPDhaDhbKCysADhaIDhbRPCysNK

antiSMASH-DB 4.0 matches for FE328_RS09035

100.0%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09035_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02890_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02830_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02865_lanthipeptide

Lanthipeptides: FE328_RS09035_lanthipeptide

1

VAWTSLVPISLAICPSTKCASITRPCNK

28

VAWTSLVPISLAICPSTKCASITRPCNK

1

VAWTSLVPISLAICPSTKCASITRPCNK

28

56.7%

NZ_BQME02000001.1and 3 others:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04090_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptideNZ_BQME02000001.1 Lanthipeptides: MFF31_RS04080_lanthipeptide

Lanthipeptides: MFF31_RS04090_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCN

27

WT ++PISLA CP+T+CASI PCN

5

WTIIIPISLAACPTTRCASIVSPCN

29

53.3%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04085_lanthipeptide

Lanthipeptides: MFF31_RS04085_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCN

27

WT ++PISLA CP+T+CASI CN

5

WTIIIPISLAACPTTRCASIVSSCN

29

with 64 more sequence matches

Only the first 10 are displayed here.

53.1%

NZ_CP063142.1and 5 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21455_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01475_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22255_lanthipeptide

Lanthipeptides: HPB58_RS21455_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCNK

28

WT +PISLA CP+T+CASI PCN

7

WTVTIPISLAACPTTQCASIVSPCND

32

51.4%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15520_lanthipeptide

3

WTSL---VPISLAICPSTKCASITRPCN

27

WT L +PISLA CP+TKCASI PC

7

WTPLTVTIPISLAGCPTTKCASIVSPCK

34

50.0%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09140_lanthipeptide

Lanthipeptides: NP440_RS09140_lanthipeptide

4

TSLVPISLAICPSTKCASITRPCNK

28

T +PIS AICP+T+CASI RPCN

9

TVTIPISAAICPTTQCASIVRPCNN

33

45.5%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18000_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20955_lanthipeptide

Lanthipeptides: KJS43_RS18000_lanthipeptide

5

SLVPISLAICPSTKCASITRPCN

27

+++P+SLAICP+TKCAS+ +PCN

10

TIIPVSLAICPTTKCASVVKPCN

32

45.5%

NZ_LT745762.1and 1 other:

NZ_LT745762.1 Lanthipeptides: B2C77_RS21505_lanthipeptide

Lanthipeptides: B2C77_RS21505_lanthipeptide

5

SLVPISLAICPSTKCASITRPCNK

28

+++P+SLAICP+TKCAS+ +PCN

10

TIIPVSLAICPTTKCASVVKPCND

33

44.1%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS20095_lanthipeptide

Lanthipeptides: BK581_RS20095_lanthipeptide

3

WTSLVPISLAICPSTKCASITRPCN

27

WT +PIS A CP+T+CAS+ +PCN

9

WTITIPISAAACPTTQCASVVKPCN

33

42.9%

NZ_LR134483.1and 1 other:

NZ_LR134483.1 Lanthipeptides: EL241_RS13590_lanthipeptide

Lanthipeptides: EL241_RS13590_lanthipeptide

3

WTSLVPISLAICPSTKCASITR

24

WT VP+S+A+CP+ KC S R

3

WTVTVPLSIALCPTAKCTSKCR

24

41.2%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23705_lanthipeptide

Lanthipeptides: WH45_RS23705_lanthipeptide

5

SLVPISLAICPSTKCASITRPCN

27

+++P+SLAICP+T+CASI CN

11

TIIPVSLAICPTTRCASIVESCN

33

38.9%

NC_023073.1and 147 others:

NC_023073.1 Lanthipeptides: U722_RS19995_lanthipeptideNC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNC_023073.1 Lanthipeptides: U722_RS19990_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19795_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19790_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016371.1 Lanthipeptides: A5891_RS19785_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20390_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS20385_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22070_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS22065_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20995_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS20990_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20685_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS20680_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21470_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS21465_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19555_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS19550_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19745_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS19750_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS19595_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20480_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS20485_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21120_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS21125_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21095_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS21090_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20030_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS20025_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20965_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS20960_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19660_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS19655_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16410_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16405_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06635_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06630_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18905_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18900_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06410_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06405_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16755_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16750_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06125_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06120_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12965_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12970_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17635_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17630_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06080_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06075_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06260_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06255_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03440_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03445_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05880_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05875_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01825_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01820_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11645_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11640_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10245_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptideNZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10240_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00590_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00595_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02970_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02965_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122695_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS1000000122690_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19740_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS19735_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS19355_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18855_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS18860_lanthipeptide

Lanthipeptides: U722_RS19995_lanthipeptide

10

SLAICPSTKCASITRPCNK

28

SLA CP+TKCASI PCN

18

SLAGCPTTKCASIVSPCND

36

36.8%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114655_lanthipeptide

Lanthipeptides: G475_RS0114655_lanthipeptide

4

TSLVPISLAICPSTKCASITRPCNK

28

T +PIS CP+TKCAS+ PCN

14

TVTIPISAWGCPTTKCASVVEPCND

38

MIBiG 4.0 matches for FE328_RS09035

24.3%

BGC0001229.4 (SBI_06989):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

7

VPISLAICPSTKCAS

21

V +S A CP+TKC S

21

VGVSAAFCPTTKCTS

35

21.4%

BGC0002110.3 (QKV49894.1):

Lanthipeptide: birimositide

13

ICPSTKCAS

21

CP+TKC S

16

FCPTTKCTS

24

10.7%

BGC0000553.3 (SSGG_RS09925):

Lanthipeptide: SRO15-2212

9

ISLAIC

14

+SL +C

5

VSLLVC

10

FE328_RS09040

Leader:

MNKDFDKELLNISGNLKEELSEADLEQISGA

Core:

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

Core with dehydrations:

GVGKWIRKLDhaKGNDhbGKVCysDhbLDhbWECysGICysPDhaHDhbCysFL

antiSMASH-DB 4.0 matches for FE328_RS09040

100.0%

NZ_CP040417.1and 7 others:

NZ_CP040417.1 Lanthipeptides: FE328_RS09040_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040419.1 Lanthipeptides: FE326_RS02895_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040421.1 Lanthipeptides: FE324_RS02835_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptideNZ_CP040422.1 Lanthipeptides: FE323_RS02870_lanthipeptide

Lanthipeptides: FE328_RS09040_lanthipeptide

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

34

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCFL

34

61.8%

NZ_KQ040792.1and 1 other:

NZ_KQ040792.1 Lanthipeptides: WH45_RS23330_lanthipeptide

Lanthipeptides: WH45_RS23330_lanthipeptide

6

IRKLSKGNTGKVCTLTWECGICPSHTCF

33

++ LS+GN GKVCTLTWECG+CP+HTCF

3

VQGLSQGNDGKVCTLTWECGLCPTHTCF

30

58.8%

NZ_CP016371.1and 7 others:

NZ_CP016371.1 Lanthipeptides: A5891_RS06120_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP027429.1 Lanthipeptides: C6P48_RS12845_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_CP033967.1 Lanthipeptides: EG882_RS17885_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptideNZ_KN050798.1 Lanthipeptides: BR62_RS0113960_lanthipeptide

Lanthipeptides: A5891_RS06120_lanthipeptide

3

GKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

G R +S+GN GK+CTLTWECG+CP+HTC+

2

GAEQRGISQGNDGKLCTLTWECGLCPTHTCW

32

with 99 more sequence matches

Only the first 10 are displayed here.

57.9%

NZ_JAGGQH010000006.1and 1 other:

NZ_JAGGQH010000006.1 Lanthipeptides: J7E20_RS10220_lanthipeptide

Lanthipeptides: J7E20_RS10220_lanthipeptide

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

G G R +S+GN GK+CTLTWECG+CP+HTCF

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCF

37

55.9%

NZ_JAMDLZ010000027.1:

Lanthipeptides: M5W82_RS15515_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

+K+SKGN GK CTLTWEC ICP+ TC+

4

KKISKGNDGKWCTLTWECSICPTKTCW

30

55.3%

NC_023073.1and 65 others:

NC_023073.1 Lanthipeptides: U722_RS06170_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP010556.1 Lanthipeptides: SB45_RS05930_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP016395.1 Lanthipeptides: BBJ33_RS06540_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP017775.1 Lanthipeptides: BK055_RS07100_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP018295.1 Lanthipeptides: BHE96_RS06300_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023075.1 Lanthipeptides: CK238_RS06735_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP023133.1 Lanthipeptides: CJP14_RS04225_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP025341.1 Lanthipeptides: CXR48_RS06135_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP028440.1 Lanthipeptides: DA378_RS05125_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP031694.1 Lanthipeptides: DXY21_RS18530_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP035393.1 Lanthipeptides: ES966_RS07170_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044133.1 Lanthipeptides: F3129_RS06725_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP044444.1 Lanthipeptides: F7V86_RS13675_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP048002.1 Lanthipeptides: GWK37_RS15585_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059405.1 Lanthipeptides: H1Q60_RS16390_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP059495.1 Lanthipeptides: H2N74_RS06615_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP064091.1 Lanthipeptides: IRJ21_RS18885_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP065790.1 Lanthipeptides: I8N72_RS06390_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP072310.1 Lanthipeptides: J4774_RS16735_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP074685.1 Lanthipeptides: KH263_RS06105_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP075054.1 Lanthipeptides: KH277_RS12985_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP083716.1 Lanthipeptides: LAZ96_RS17615_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP088300.1 Lanthipeptides: LQ763_RS06060_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP090905.1 Lanthipeptides: L0961_RS06240_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP092110.1 Lanthipeptides: LGL65_RS03460_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP094618.1 Lanthipeptides: MTX90_RS05860_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP116013.1 Lanthipeptides: PF986_RS01805_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_CP119675.1 Lanthipeptides: PX690_RS11625_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAJNPN010000001.1 Lanthipeptides: LQ568_RS00610_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_JAQEMJ010000002.1 Lanthipeptides: PGW53_RS02950_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_KB206086.1 Lanthipeptides: A154_RS0102805_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_LN999829.1 Lanthipeptides: BAMMD1_RS05930_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptideNZ_PVRO01000002.1 Lanthipeptides: C6354_RS06030_lanthipeptide

Lanthipeptides: U722_RS06170_lanthipeptide

1

GVGKWIRKLSKGNTGKVCTLTWECGICPSHTCF

33

G G R +S+GN GK+CTLTWECG+CP+HTC+

5

GGGAEQRGISQGNDGKLCTLTWECGLCPTHTCW

37

52.9%

NZ_AUCI01000015.1and 1 other:

NZ_AUCI01000015.1 Lanthipeptides: G475_RS0114640_lanthipeptide

Lanthipeptides: G475_RS0114640_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R LS+GN G CT+TWECG+CP+HTC+

6

RGLSQGNDGDYCTITWECGMCPTHTCW

32

52.9%

NZ_BQME02000001.1and 1 other:

NZ_BQME02000001.1 Lanthipeptides: MFF31_RS04105_lanthipeptide

Lanthipeptides: MFF31_RS04105_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R +S+GN GK CTLTWEC +CP+ TCF

4

RGISQGNDGKYCTLTWECSVCPTLTCF

30

50.0%

NZ_BOSN01000007.1and 3 others:

NZ_BOSN01000007.1 Lanthipeptides: KJS43_RS18005_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptideNZ_JAHHXV010000040.1 Lanthipeptides: KM914_RS20960_lanthipeptide

Lanthipeptides: KJS43_RS18005_lanthipeptide

9

LSKGNTGKVCTLTWECGICPSHTCF

33

+S+GN GK CT+TWEC ICP+HTC+

7

ISQGNDGKYCTITWECSICPTHTCW

31

50.0%

NZ_CP063142.1and 10 others:

NZ_CP063142.1 Lanthipeptides: HPB58_RS21475_lanthipeptideNZ_FOXX01000007.1 Lanthipeptides: BM012_RS26100_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_JALAMS010000001.1 Lanthipeptides: MOC86_RS01460_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LVYL01000023.1 Lanthipeptides: A3863_RS12035_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAG01000015.1 Lanthipeptides: A4R27_RS06450_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptideNZ_LWAI01000057.1 Lanthipeptides: A4U60_RS22240_lanthipeptide

Lanthipeptides: HPB58_RS21475_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R +S+GN G CT+TWEC ICP+HTC+

4

RGISQGNDGHQCTITWECSICPTHTCW

30

50.0%

NZ_CP101913.1and 1 other:

NZ_CP101913.1 Lanthipeptides: NP440_RS09135_lanthipeptide

Lanthipeptides: NP440_RS09135_lanthipeptide

9

LSKGNTGKVCTLTWECGICPSHTCF

33

+S+ N GK CTLTWEC ICP+HTC+

7

ISEDNDGKYCTLTWECSICPTHTCW

31

50.0%

NZ_FOXD01000022.1and 1 other:

NZ_FOXD01000022.1 Lanthipeptides: BM124_RS15270_lanthipeptide

Lanthipeptides: BM124_RS15270_lanthipeptide

7

RKLSKGNTGKVCTLTWECGICPSHTCF

33

R +S+GN G CT+TWECG+CP+HTC+

6

RGISQGNDGDYCTITWECGMCPTHTCW

32

50.0%

NZ_KV917378.1and 1 other:

NZ_KV917378.1 Lanthipeptides: BK581_RS07320_lanthipeptide

Lanthipeptides: BK581_RS07320_lanthipeptide

6

IRKLSKGNTGKVCTLTWECGICPSHTCF

33

++ +S+GN GK CT+TWEC ICP+HTC+

3

VQGISQGNDGKYCTITWECSICPTHTCW

30

MIBiG 4.0 matches for FE328_RS09040

26.5%

BGC0000517.4 (BAB04173.1):

Lanthipeptide: haloduracin β or haloduracin α

12

GNTGKVCTLTWEC

24

GN G CTLT EC

11

GNKGAYCTLTVEC

23

26.5%

BGC0002110.3 (QKV49893.1):

Lanthipeptide: birimositide

12

GNTGKVCTLTWEC

24

GN G CTLT EC

13

GNNGGWCTLTKEC

25

12.8%

BGC0001229.4 (SBI_06990):

Lanthipeptide: SBI-06990 A1 or SBI-06989 A2

18

CTLTWEC

24

CTL+ EC

28

CTLSKEC

34

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.26 out of 26.06

Confidence: strong

CRP

Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.19 out of 19.26

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.38 out of 28.19

Confidence: medium

Additional weak hits (4):

DosR

Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 19.39 out of 29.51

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 25.95 out of 39.62

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 26.44 out of 39.62

Confidence: weak

CelR

Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 18.87 out of 30.11

Confidence: weak

Lanthipeptides

TFBS Finder

Core peptide predictions

FE328_RS09035 - Class II

Cleavage pHMM score: -0.70

RODEO score: 0

Monoisotopic mass: 2832.5 Da

Molecular weight: 2834.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2852.4 Da N = 1; 2870.4 Da N = 2; 2888.5 Da N = 3; 2906.5 Da N = 4

FE328_RS09040 - Class II

Cleavage pHMM score: -0.80

RODEO score: 0

Monoisotopic mass: 3613.9 Da

Molecular weight: 3616.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3634.3 Da N = 1; 3652.3 Da N = 2

allorf_1876713_1876829 - Class II

Cleavage pHMM score: -6.20

RODEO score: 0

Monoisotopic mass: 2225.2 Da

Molecular weight: 2226.7 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 2244.7 Da N = 1; 2262.7 Da N = 2

FE328_RS09035 - Class II

Cleavage pHMM score: -0.70

RODEO score: 0

Monoisotopic mass: 2832.5 Da

Molecular weight: 2834.4 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2852.4 Da N = 1; 2870.4 Da N = 2; 2888.5 Da N = 3; 2906.5 Da N = 4

FE328_RS09040 - Class II

Cleavage pHMM score: -0.80

RODEO score: 0

Monoisotopic mass: 3613.9 Da

Molecular weight: 3616.3 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3634.3 Da N = 1; 3652.3 Da N = 2

TFBS definitions

Regulator	Description
CRP	Cyclic AMP receptor protein
MogR	Repressor of flagellar motility genes
ZuR variant 1	Zinc-responsive repressor