LOCUS       NZ_CP040414            22499 bp    DNA     circular CON 23-APR-2024
DEFINITION  Dolosigranulum pigrum strain KPL3090 chromosome, complete genome.
ACCESSION   NZ_CP040414
VERSION     NZ_CP040414.1
KEYWORDS    RefSeq.
SOURCE      Dolosigranulum pigrum
  ORGANISM  Dolosigranulum pigrum
            Bacteria; Bacillota; Bacilli; Lactobacillales; Carnobacteriaceae;
            Dolosigranulum.
REFERENCE   1  (bases 1 to 2009643)
  AUTHORS   Flores Ramos,S.Z., Brugger,S.D., Skeete,C.A., Cotton,S.,
            Eslami,S.M., Gao,W., Bomar,L., Fernandez Escapa,I., Roberts,R.J.,
            Johnston,C.D. and Lemon,K.P.
  TITLE     The nasal commensal Dolosigranulum pigrum exhibits stable synteny
            and highly similar strain circulation over a 20-year span
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2009643)
  AUTHORS   Flores Ramos,S.Z., Brugger,S.D., Skeete,C.A., Cotton,S.,
            Johnston,C.D. and Lemon,K.P.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAY-2019) Microbiology, Forsyth Institute, 245 First
            Street, Cambridge, MA 02142, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 02-AUG-2018
            Assembly Method                   :: HGAP v. 4.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 423x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017655685.1-RS_2024_04_23
            Annotation Date                   :: 04/23/2024 02:23:56
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 1,936
            CDSs (total)                      :: 1,864
            Genes (coding)                    :: 1,836
            CDSs (with protein)               :: 1,836
            Genes (RNA)                       :: 72
            rRNAs                             :: 4, 4, 4 (5S, 16S, 23S)
            complete rRNAs                    :: 4, 4, 4 (5S, 16S, 23S)
            tRNAs                             :: 56
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 28
            CDSs (without protein)            :: 28
            Pseudo Genes (ambiguous residues) :: 0 of 28
            Pseudo Genes (frameshifted)       :: 9 of 28
            Pseudo Genes (incomplete)         :: 15 of 28
            Pseudo Genes (internal stop)      :: 6 of 28
            Pseudo Genes (multiple problems)  :: 2 of 28
            CRISPR Arrays                     :: 1
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 07:01:46
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 806937
            Orig. end                         :: 829436
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP040414.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            This genome has a base modification file available.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22499
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-ii"
                     /region_number="2"
                     /rules="cds(LANC_like and DUF4135)"
                     /tool="antismash"
     cand_cluster    1..22499
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(LANC_like and DUF4135)"
                     /kind="single"
                     /product="lanthipeptide-class-ii"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22499
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12499](+)"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12499
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(LANC_like and DUF4135)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-ii"
                     /protocluster_number="1"
     misc_feature    complement(264..273)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 17.44"
                     /tool="antismash"
     misc_feature    complement(743..760)
                     /note="TFBS match to HipB, Bacterial antitoxin HipB,
                     confidence: weak, score: 23.05"
                     /tool="antismash"
     misc_feature    complement(796..809)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.25"
                     /tool="antismash"
     gene            complement(847..1314)
                     /locus_tag="FE331_RS03980"
                     /old_locus_tag="FE331_03935"
     CDS             complement(847..1314)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004636451.1"
                     /locus_tag="FE331_RS03980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03935"
                     /product="universal stress protein"
                     /protein_id="WP_077862252.1"
                     /transl_table=11
                     /translation="MLQEYQRILVAVDGSESANRALRKAVAVAKRNDATLFITHVIDTR
                     AFQPYEAFDASVSKSAKSEANSTLNACKLYAENHGLNDVHLLLEHGSPKKLIARDLPND
                     YDIDLIMLGATGLNTVERFFIGSVSENVVRSALCDVLVVRTDAENNYEIGH"
     ncRNA           complement(1433..1615)
                     /db_xref="RFAM:RF00013"
                     /gene="ssrS"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00013"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /locus_tag="FE331_RS03985"
                     /ncRNA_class="other"
                     /note="Derived by automated computational analysis using
                     gene prediction method: cmsearch."
                     /old_locus_tag="FE331_03940"
                     /product="6S RNA"
     gene            complement(1433..1615)
                     /gene="ssrS"
                     /locus_tag="FE331_RS03985"
                     /old_locus_tag="FE331_03940"
     gene            complement(1716..2981)
                     /locus_tag="FE331_RS03990"
                     /old_locus_tag="FE331_03945"
     CDS             complement(1716..2981)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004636450.1"
                     /locus_tag="FE331_RS03990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03945"
                     /product="replication-associated recombination protein A"
                     /protein_id="WP_077862253.1"
                     /transl_table=11
                     /translation="MKQPLAYRMRPESIDEVVGQQHLVGEGKIIWRMVEAKRLSSMILY
                     GPPGIGKTSIASAIAGSTKYAFRMLNAATESKSDLNVVVEEAKMSGTVILLLDEIHRLN
                     KPKQDFLLPHLESGRIIMIGATTENPYLSIHPAIRSRSQIFELNPLQEADIISALNRAL
                     DDDTNGLGHLELTVDEAALRHFARATNGDLRSSLNALELAAESTAPTNGSIHITLSIAE
                     ECIGRQALTHDKDGDAHYDVISAFQKSIRGSDVDASLHYLARLMVAGELEVACRRLMVT
                     AYEDIGLANPAGAARAVTAVQAALRLGLPEARIPLANAVVELALSPKSNTAYKALDQAI
                     SDIREGKAGEVPKHLKDTHYSGADSLGRGQGYKYPHNYDNAWVKQDYLPDRLAKAQYYM
                     PKTNSKFESAIARQFEKFNTDQ"
     gene            complement(3026..4009)
                     /locus_tag="FE331_RS03995"
                     /old_locus_tag="FE331_03950"
     CDS             complement(3026..4009)
                     /EC_number="6.3.4.15"
                     /GO_function="GO:0004077 - biotin-[acetyl-CoA-carboxylase]
                     ligase activity [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00121.1"
                     /locus_tag="FE331_RS03995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03950"
                     /product="biotin--[acetyl-CoA-carboxylase] ligase"
                     /protein_id="WP_208967998.1"
                     /transl_table=11
                     /translation="MHSHLIFQLNKQFPNPVPTETLSQQFNCSAAEITEAVEELRALGL
                     VIHSYNSGFQLASPLYSIPGIKTYLNTQTFGTQGLYLFETIDSTHTYVSNNLSTIDHGS
                     VLLAYSQTAGRGRRGRKWSSPIGKSLSLSIVLKEFSAQMKPTLLTQLTAAALQQALSET
                     GLPVAIKWPNDLLINRRKVAGVLTEAMFERQVLQAITIGIGINLNQSQSDFPTEIHTKA
                     TSLALETESLFFADKLIAQFLKIFEQFYQDYQQSLDPEPFLSICRQESAVIGEIVTVVQ
                     GDKRRDVEVLGIEATGELLVRDLSSQEKMTLISSEVSLRNPDGSYI"
     gene            4131..5813
                     /locus_tag="FE331_RS04000"
                     /old_locus_tag="FE331_03955"
     CDS             4131..5813
                     /EC_number="3.1.-.-"
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0004540 - RNA nuclease activity [Evidence
                     IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004636448.1"
                     /locus_tag="FE331_RS04000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03955"
                     /product="ribonuclease J"
                     /protein_id="WP_077862255.1"
                     /transl_table=11
                     /translation="MSNVKIIPLGGVRENSKSLYVVEVDAQIFVLDCGLMFPEGELYGI
                     DAVIPDFTYLKQNKERIAGVFLSHGHEDAIGALPYFIDEFNVPVFGSELTIELARLQVE
                     SVIGKGNFSDYHVVDSSLAIDFGEVKVHFFQVTHTIPDAMGISIETPEGHVVYTGNFKF
                     DQSADGPYRTNLNHISDIGKERVLALLSSSLGAESLEENAPDKRVQSVVTEIFQDAPTR
                     IIVAAVQSNLLRIQQIINAAHATNRKVFISSSKSQDIINVAIDLGKLTLPKKDILQSIS
                     DLEKFHDDETVILETGSSGEPIKALREMATNQHPNIGIRNEDTVFIATNPSVAMEVEVA
                     ECENLIYRSGGEVVKLSNQIKASGHATPNDLQLMMNLLHPEYFIPVQGEYRVLAAHARL
                     AHETGIPHEHIFTLSNGDVVEYKKGKMHSTGTVPADNTLVDGIGIGDVGNIVLRDRRLL
                     SNDGIFVAVVTIDRRKQKIVAKPHIVTRGFVFVKANYDLINESTTIVEKVIQQNLKHND
                     FDWGSIKSEIRNELSDYLFKETKRRPIILPVIMEVNQRRWYDK"
     gene            5907..7361
                     /gene="cls"
                     /locus_tag="FE331_RS04005"
                     /old_locus_tag="FE331_03960"
     CDS             5907..7361
                     /GO_function="GO:0008808 - cardiolipin synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0032049 - cardiolipin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cls"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015381020.1"
                     /locus_tag="FE331_RS04005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03960"
                     /product="cardiolipin synthase"
                     /protein_id="WP_004636447.1"
                     /transl_table=11
                     /translation="MSYISTIFWWFIIINSTLAIFTIFRDKTRDIASIWAWLLALIMLP
                     GIGFIAYLFFGRGMSDKDIYDIKQQDQIGLRELKDTLTERYEHQHEARDEVFSNNKKEM
                     VSLFQGLDNAALTRDNEVDIYSDGKEKFDQLLEDIKQAKHHIHLVYYIFRGDKIGRAIV
                     DALEEKANQGVEVRVLYDPVGTRWMTRSFFKKLKSFGGQACPSFGERMHILNMRLNYRN
                     HRKIVVIDGKIGYTGGFNVGDDYLGEYPEMGYWRDTHVRIVGNGVLPLQTRFLTDWNAS
                     ADEAQQVPYDNQYFPIQETTGDVDLQIVSSGPDSTEQQIKKGFIKMISLARESVYIQTP
                     YLVPDDAVLETIDIASKSGVEVHVMIPNKPDHPFIYQATLSYAEQLVEYGAHVHIYDGG
                     FLHAKTIIVDDEMLSIGTANFDIRSFKLNFEVNTFMYSEKLAQAYHAQYMSDLQHAYEL
                     TPDIIANYSLWERFKQQFSRLFSPIL"
     gene            complement(7448..7801)
                     /locus_tag="FE331_RS04010"
                     /old_locus_tag="FE331_03965"
     CDS             complement(7448..7801)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004636446.1"
                     /locus_tag="FE331_RS04010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03965"
                     /product="DUF2200 domain-containing protein"
                     /protein_id="WP_077862257.1"
                     /transl_table=11
                     /translation="MGRHKIFDMAVSAVYPHYVNKAEKKGKTAEQVDELMCWLTGYSQD
                     ELHEQLEANVSFEKFFDQAPKLHPNRTLIKGVICGKRVEDIEDPLMQNIRYLDKLIDEL
                     ARGKKFENIKRTQ"
     misc_feature    complement(7856..7869)
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: medium, score: 21.21"
                     /tool="antismash"
     gene            7982..8395
                     /locus_tag="FE331_RS04015"
                     /old_locus_tag="FE331_03970"
     CDS             7982..8395
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FE331_RS04015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FE331_03970"
                     /product="hypothetical protein"
                     /protein_id="WP_142970426.1"
                     /transl_table=11
                     /translation="MNPESQHQNLQLQLQETITHLDKITDQLESAKRWSWADLLGGEFI
                     TSMVKRKKMKNISEDLQQLQPKLQHLKHALEDANIQVDSAIDHSTSRQFFDTFFDNIIT
                     DLKVQGEIKDMLAELKELRQALTTYQQQIDSGV"
     gene            8618..8815
                     /locus_tag="FE331_RS04020"
                     /old_locus_tag="FE331_03975"
     CDS             8618..8815
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF016486.4"
                     /locus_tag="FE331_RS04020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03975"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_208967999.1"
                     /sec_met_domain="L_biotic_A (E-value: 1e-09, bitscore:
                     34.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRQSVAIETEQLELVQAVSDERLEVLVGGKGPGLLKTLTKDCP
                     GTVSDVCVNLAVVSTCKKCE"
     CDS_motif       8618..8710
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEQRQSVAIETEQLELVQAVSDERLEVLVGG"
                     /locus_tag="FE331_RS04020_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8711..8815
                     /prepeptide="core"
                     /locus_tag="FE331_RS04020_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="0.20"
                     /molecular_weight="3400.0"
                     /monoisotopic_mass="3397.8"
                     /core_sequence="KGPGLLKTLTKDCPGTVSDVCVNLAVVSTCKKCE"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEQRQSVAIETEQLELVQAVSDERLEVLVGG"
                     /leader_location="[8617:8710](+)"
                     /alternative_weights="3418.1"
                     /alternative_weights="3436.1"
     gene            8912..9622
                     /locus_tag="FE331_RS04025"
                     /old_locus_tag="FE331_03980"
     CDS             8912..9622
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FE331_RS04025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FE331_03980"
                     /product="hypothetical protein"
                     /protein_id="WP_111950663.1"
                     /transl_table=11
                     /translation="MKTLLKKEFNTHGQNKLLYIVLLVVGIMQVFLARSLFGAEGGGAL
                     AKTIFQDNSIIYSLVATIFTPIIAGVLGYYFISSEFEQRTWEMYFLGIKNKSKILWTKY
                     VVCLFYWIAYNICVWGIFLGLSAFYWQRQVDLFFVWLIPISTTLLGLFLFTAQLSMHFL
                     IPNTQISISIVMVFIGIVGMVLESWLIYVLPLSSGFYLNHIDQFNNLEYMRLIIQNIIF
                     SIILISIVVKRFHL"
     gene            9713..9892
                     /locus_tag="FE331_RS04030"
                     /old_locus_tag="FE331_03985"
     CDS             9713..9892
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) L_biotic_A"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014294876.1"
                     /locus_tag="FE331_RS04030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03985"
                     /product="type A2 lanthipeptide"
                     /protein_id="WP_208968000.1"
                     /sec_met_domain="L_biotic_A (E-value: 2.1e-11, bitscore:
                     40.4, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKYNDENKKAQKTVEVIKDKELEQMIGGVGPGLVRTLTKDCPNV
                     VPKVCFDGKCKYCR"
     CDS_motif       9713..9799
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MEKYNDENKKAQKTVEVIKDKELEQMIGG"
                     /locus_tag="FE331_RS04030_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9800..9892
                     /prepeptide="core"
                     /locus_tag="FE331_RS04030_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="4.30"
                     /molecular_weight="3260.9"
                     /monoisotopic_mass="3258.7"
                     /core_sequence="VGPGLVRTLTKDCPNVVPKVCFDGKCKYCR"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MEKYNDENKKAQKTVEVIKDKELEQMIGG"
                     /leader_location="[9712:9799](+)"
     gene            10001..12499
                     /locus_tag="FE331_RS04035"
                     /old_locus_tag="FE331_03990"
     CDS             10001..12499
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: DUF4135"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-ii: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1070: lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF024964.4"
                     /locus_tag="FE331_RS04035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03990"
                     /product="DUF4135 domain-containing protein"
                     /protein_id="WP_208968001.1"
                     /sec_met_domain="DUF4135 (E-value: 1.8e-58, bitscore:
                     195.3, seeds: 79, tool: rule-based-clusters)"
                     /sec_met_domain="LANC_like (E-value: 1.1e-24, bitscore:
                     83.7, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEDTQLINKKNSFDQVIDEITTYYFQQIKIVNIFNVNTIKQQLLD
                     EVRKLYLPALVDDINHYRLNVDESSTPEEQYMTYCRLFNREKLTELHTKYPLLDKWVHN
                     TVERYKTNLKFLSDAIAIDYDEIVKVFNLSQEAKDNIEVMSFVGDVHHGSQAIQFKLAG
                     KEFYLKRNGQLVLELVEKLKETIIASSQFDFPKTYLGEQYFIQEAVQQEPCQSEGDIAD
                     FYFNMGMLLSFVYMLNGSDMHNENVIASGKTPYVVDIETLINPVDFSNDSCIEQSIFQT
                     AMLPMKYNPTFEGIVDCSSIGEVVTVRKKIFEAENPFSSRIRLKLKDVYYEDIATHLPL
                     YDSEYHSVGSYLHKVEEGFTVGYRTIIGNKKNLINIVEQYSVAVQCRLVMRNTIVYSEL
                     LKRLNSPDLLVSISQSRQFLHHFLWDIRYITQNKQEYINEEINQLLEGEVPYFTYGNEG
                     TILSKDVESLASIKESLLMKIEQFSEEDLSFQLDLLRVAFNIDNYNFTRLQMSHLKESV
                     NDLIHESIYDETILTIQKDPKGNYVYNAIGLGVYEGQLGLWLTDKCFHRHISYDDVIRD
                     IINSKDIGGINGYASLCVCQRLLGLPLSNVMIDETKIAQIDVIDGLAGLILVLYSDYRE
                     SPSKSKLTQLINLLELFEKNYNVDEINCLGFAHGISGIKIIFYIMSQLLDTTFRDNYRE
                     IDKLDNSEDYLSATWCNGLTGHLIAEYILYKISGDANHMNNVTKQLPKLVQLAYNMDDY
                     CLCHGLFGVLDFLLTVKREGKLSSDMIRKYYELERYAYRYLDEHDVLSKDISLFTGLGG
                     ISYYLNRKESDIKSVLMFGY"
     gene            12519..14564
                     /locus_tag="FE331_RS04040"
                     /old_locus_tag="FE331_03995"
     CDS             12519..14564
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="FE331_RS04040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_03995"
                     /product="cysteine peptidase family C39 domain-containing
                     protein"
                     /protein_id="WP_208968002.1"
                     /sec_met_domain="Peptidase_C39 (E-value: 1e-32, bitscore:
                     109.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYVPEIIQFNQNDCGPCCLSMLLNYYGYESDIEELTELKSAIYG
                     WSMLDIKRIGEKFGLESNVYNVQTIQPLKQVKLPAILFWEHSHFVVLEKIIADEIIIVN
                     PSVGRQTVNKKVFWEKFTGYIMEVSLGQSFQKKKIPWYDKVQLYMNKDIWNFKIKWQYV
                     ALLIVYSALLFISPLAVSEVISSVGLDHIPYGKIMALVGVVIATGITNYLLDKRRQREK
                     LDLEESSTLKLYNEISKKSKVEFSKYHSGDTLSRLHVNSDICQFITIGIPNMLLSIGLF
                     MVVTIYLLIRVGMMSLILSGVILLIALINGLFIVPLMKMAQTESYKFSDFRTVLSDGII
                     SHNYFINSGIGGTYTEKVTHSLKDYLNVSYDRSKIEAKSNTVQQMTSTFFSLILSVLGM
                     GLILIFPNDRSNISLLMTTGMILYSPAMSVLSTVLTVSRVAPHMKRLNEMIKNNQQNYT
                     TKRLKDGSIKVKDLTFQYENTADPIINDRSFRLNHGEKLVICGESGSGKTTLIDLLLGL
                     NKQYDKGEVVVGGVNTKEYDLNLKEDVCYITQPTKLFKGTLKDNLKLYLDHYDVEQLIE
                     ITADMELDTLGRECDLSNHLILEDGLNFSQGQKQRLGLLRLFLGKYKIIIVDEPTSNLD
                     DRLARKIFSMIDELNTTKIIITHDEKYIQQADKVLNLGDDEHEYQV"
     gene            14548..15456
                     /locus_tag="FE331_RS04045"
                     /old_locus_tag="FE331_04000"
     CDS             14548..15456
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004636443.1"
                     /locus_tag="FE331_RS04045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_04000"
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_208968003.1"
                     /transl_table=11
                     /translation="MNIKFNNVNKTYGRKQVLQDINITIPEGKIYGFIGANGAGKTTAM
                     KILTGLTPASSGTVTFDEKELNQLENKAKAFGAFISTPTYYKNLTAYENLAIIQDVLEE
                     PKDEIDRVLEIVGLADAKSKTIAEYSFGMKQRLGLAFSFLNDPDILILDEPTNGLDPKG
                     IVEIRELLYSLSKEQGKTIFISSHNISELESIADMIGIIQNGKLIFEGELDELYVSGES
                     SYLLEIDDIDQAKTVLSEEGISFTNKEHKFQIKSSKQRIPEVVKALLDRDIAIFEITPN
                     KNLERIFLDLTDGDDEHVDTH"
     gene            15440..16165
                     /locus_tag="FE331_RS04050"
                     /old_locus_tag="FE331_04005"
     CDS             15440..16165
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024141.4"
                     /locus_tag="FE331_RS04050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_04005"
                     /product="ABC transporter permease"
                     /protein_id="WP_181503605.1"
                     /transl_table=11
                     /translation="MWTLIKHEFKTHGTQPILYLILGIMGLLQVFLTTIMIKTTDTVSI
                     QGSYIQTVFQTNNAIFLSNSIIFIFSVGAVIGYYIISVEYQNNTWEMLLLGTGSKSKVL
                     WAKYIVSTLYYLSYQVLFYSLFLLVQSTYFNLQIEISFSLLMLVSIMFLSLVLFTAQIA
                     CHYLIKNGTTAIACAVGFLIMLVILPSTDLFRYVIRLLTPGYLAGLDEFSVTGFVSVVA
                     LNIIVASSMMSLVVKQFKL"
     gene            16178..16876
                     /locus_tag="FE331_RS04055"
                     /old_locus_tag="FE331_04010"
     CDS             16178..16876
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FE331_RS04055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FE331_04010"
                     /product="hypothetical protein"
                     /protein_id="WP_208968004.1"
                     /transl_table=11
                     /translation="MFLKLELLKFKRRISVGALCLFMLLVVGLQTFIAMRTPELETNVF
                     YIGSLEWFSGIIFPALAPVFITLSVYADTEYKGIQNFVLKGVKPQKLSQSTWKFFLVAL
                     PLLYLSYVMIPFVFMFFRGGLTSEGIWSVVIYSGLSVISIVSLVNISFIIYRITMNDFL
                     PVIIAVAGVMLAFAPFGQDMWLVNPYLYMYYSAGHSGFNWYHYAVIIGLCAVSFAVYAY
                     VSYYKKTKRA"
     gene            16881..18365
                     /locus_tag="FE331_RS04060"
                     /old_locus_tag="FE331_04015"
     CDS             16881..18365
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1048: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FE331_RS04060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FE331_04015"
                     /product="hypothetical protein"
                     /protein_id="WP_185908145.1"
                     /transl_table=11
                     /translation="MEKWTPKIDVIYHIVFSVLAVYLFLGYKGVSYLPLMMSLWLLLLL
                     FDYMMMTIIGVRTQIARLIVWTFRLAQVQSISLMTTIQLPLVIRYVLLMMLLNLLCQCI
                     TSLLTQYVDNRLLMRRLGIGLVVGIGLWTDYANILFIAYIVYVLFSTILAIKQRINHHV
                     YTKNKHTGYWVLVAAFSLQLIPLLGLVILVVLSSQLFTQVWLFFMAVASTLLMLIAGFN
                     HKAVVGQASKWLSLIFCTLLYIYIFVLILGLNLSLVLFILYIIVSIMYILTLTDVFGNH
                     QVNAVRLIKREEALKQDFSNYLHDDVLQDINVLIKMTTLEPSEKTQAFLREQLSALNDQ
                     LRQQMNQYSPQLSKHLTLQENYRLLVRSLEQTYPNQAVSTSFSMNRNLTLPGPYDVLVY
                     RWLRELIHNVYKHAGASQLDIHVAAYDELIIVLVEDDGCFKKGSHLEIGHGLYVIQEQV
                     EAIGGQLYIEANRPRGLRMRVEFSVMGGEIIEDFVN"
     gene            18346..18945
                     /locus_tag="FE331_RS04065"
                     /old_locus_tag="FE331_04020"
     CDS             18346..18945
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1016: LuxR family
                     DNA-binding response regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004636437.1"
                     /locus_tag="FE331_RS04065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_04020"
                     /product="response regulator transcription factor"
                     /protein_id="WP_112768042.1"
                     /transl_table=11
                     /translation="MKILLIDDHKLFSQSLALVLDQTTSDVQVDMINSEGELPDDLSEL
                     TVYDVLVLDINLDKGFSEDGFELAERVRAVAVDLPILMLTGFDLPVYEYQAHKLELSGF
                     VNKNIGTEDLLSLLKHVKDGGRHFTTENWFIDELTPRERELLGAIATGRKRKIIAEEMY
                     ISERTLTNHMQSIMDKLEVNSTIEAIQKARELGYLK"
     CDS             18942..19052
                     /gene="allorf_0825879_0825989"
                     /locus_tag="allorf_0825879_0825989"
                     /protein_id="allorf_0825879_0825989"
                     /tool="antismash"
                     /transl_table=1
                     /translation="MISGGRKMTFGVYGSCALNDCLIYSCIALNWGVNWG"
     CDS_motif       18942..18974
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MISGGRKMTFG"
                     /locus_tag="allorf_0825879_0825989_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       18975..19052
                     /prepeptide="core"
                     /locus_tag="allorf_0825879_0825989_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class II"
                     /score="-6.80"
                     /molecular_weight="2699.1"
                     /monoisotopic_mass="2697.2"
                     /core_sequence="VYGSCALNDCLIYSCIALNWGVNWG"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MISGGRKMTFG"
                     /leader_location="[18941:18974](+)"
     gene            19073..19255
                     /locus_tag="FE331_RS04070"
                     /old_locus_tag="FE331_04025"
     CDS             19073..19255
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FE331_RS04070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FE331_04025"
                     /product="hypothetical protein"
                     /protein_id="WP_111974584.1"
                     /transl_table=11
                     /translation="MMKYAPYSLLALAGILVYLTVNRYITMHSINVVPPIGAILCVIFF
                     FVWRNHLKQQGYYDD"
     gene            19778..20122
                     /locus_tag="FE331_RS04075"
                     /old_locus_tag="FE331_04030"
     CDS             19778..20122
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="FE331_RS04075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="FE331_04030"
                     /product="hypothetical protein"
                     /protein_id="WP_208968005.1"
                     /transl_table=11
                     /translation="MKVECTAVERLIQSGVNIKHKQLPKICFWLGVVVFTVAVLLPTDL
                     FQSITWIEKILGELKPVGLATIFLLPIIGSVGVVGSIMNKSVLYGSLNVALILSFPLMI
                     LVSNIVQALF"
     gene            20205..20432
                     /locus_tag="FE331_RS09690"
                     /old_locus_tag="FE331_04035"
                     /pseudo=""
     CDS             20205..20432
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039402.3"
                     /locus_tag="FE331_RS09690"
                     /note="internal stop; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_04035"
                     /product="DUF6290 family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTIVSVRLNKEEEKAINSYATLTG"
     gene            complement(20549..21178)
                     /locus_tag="FE331_RS04080"
                     /old_locus_tag="FE331_04040"
     CDS             complement(20549..21178)
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006152256.1"
                     /locus_tag="FE331_RS04080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="FE331_04040"
                     /product="tetratricopeptide repeat protein"
                     /protein_id="WP_236654080.1"
                     /transl_table=11
                     /translation="MINQAWGQFSRGNIPKAKQLVDDYINEQATTDYNALNLLGYIYLE
                     DGKIDKAESTYQQWLQLSRKNHDIEQEHIALHQLAMVYRMREDYGQALELIQQEARIIE
                     QHFPNNLLKQSVNNYEQGYLRMKLQQLNEAVSFMAQSLTQAEQTDDLIAQACAQRGMGE
                     ICVAQHKPSLARKYFKRAIQLFEQGGDTIGAQEVQLLMSQLLTDKT"
     misc_feature    complement(21269..21285)
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.32"
                     /tool="antismash"
     misc_feature    21616..21628
                     /note="TFBS match to MatP, Cell cycle regulator,
                     confidence: weak, score: 19.7"
                     /tool="antismash"
     misc_feature    21952..21969
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: medium, score: 19.05"
                     /tool="antismash"
ORIGIN
        1 gacagtttgg aaaagagggg ctttttcttg ccaagcggtt tcccaagctt caagaacttt
       61 ggcgcgttct ttaggagtct cagcggatgt tagtaagtta tcagcttgtg ctgcagagta
      121 ctcttttagc tcaccatcgc gttcaatttt aacggtaaca gaagcgacta aatcatcata
      181 catatcgctc cacccattga atccgtcaac ggataattga ttgatcgctg attctaaatc
      241 taagctgagt agttctttgg cttggtcgcg ttcttcattt aaacggaaag caatggactg
      301 gaagggttca tctgccagta gagcttgcca atcatcatta ctgatagttt ctattttttt
      361 cgtcaattca gttgagtaat tgctgaattg agtggcaagt aagcttaatt tgttaatgtg
      421 aataggagcg tgcgggtcat cttgcttagc tgatagatgc gccatagaga atgtaaagcc
      481 ttgtgatagg ccgttagaga tgtcatcaga taagttgaaa atagttgcta gtttatcagc
      541 gtgaaccgcg ccttcttctg gggtccattt ttttaccaat tcaccgaaac ggtcaatatc
      601 agtttgtaat gcttcaattt tttcttttaa ttcaggagaa ttactaccgc ctgaaaagac
      661 ggattctaaa tcccaaactt gttcataagt cataattatc atcctttcgt atgttcatta
      721 ttgtacacta agcctatgtt aatatccact ttaagggttg ttatctgcct ggttttataa
      781 aaaagcagcc agccatcacg aagagtgaga cagctagctg cttaaatgat gaatctataa
      841 tatcgattag tgtccaattt cataattgtt ttccgcatca gttcgaacga caaggacatc
      901 acaaagagca gaacggacaa cattttcgga gacggagccg atgaagaagc gctcaacagt
      961 gtttagtccg gttgcaccaa gcataattag gtcaatatca tagtcatttg gtaaatcacg
     1021 ggcgatcaac ttcttcggtg agccgtgttc taagaggaga tgtacatcat tcagtccatg
     1081 gttttcggca tataacttgc atgcatttaa ggtagagtta gcttcggatt tcgctgattt
     1141 ggagacgcta gcgtcgaagg cttcataggg ctggaaggca cgtgtatcaa ttacatgagt
     1201 aataaataac gtggcatcat tacgtttggc gacagcaacc gcttttcgca atgcacggtt
     1261 agcactctca gacccatcaa ctgcaacaag tattcgttga tattcttgca acatttgtct
     1321 cattcctttc acttaattgt tatgtacagt ataccaaaaa tcaaacggtt tcacaaaaga
     1381 taataataaa aagccactga tataagataa tcagtgacca ttttttatgt acgaggtatc
     1441 cactggtgcc gatccgttgt ctgaaaggtt gtacccgcta tttgcaggtg ggcttctcca
     1501 ctcacgcatc tgacgtccaa gtgaaaaggc ttgtcatgaa catgagcttt cgaatcccaa
     1561 tgtataaatg ttcggtcaac tcgttaaata gacaactcga acacctcaga tacctcacct
     1621 atatattagc atgtcagtga aaaaatgtca attgctctta ccaattcttt caaatcggaa
     1681 gcattctctg tgtgactacg tacttaaata gcacattatt gatccgtgtt aaatttctca
     1741 aattgtctag cgatggctga ctcgaatttg ctatttgttt ttggcatgta atattgtgct
     1801 ttagcgaggc gatcaggtaa ataatcttgc ttaacccacg cattatcata gttatgagga
     1861 tatttgtatc cttggccgcg tccgagtgaa tcggctcctg aataatgagt atcttttaag
     1921 tgcttgggaa cttcaccggc ttttccttct ctaatatcac taatagcttg atccagtgct
     1981 ttataagctg tattagattt aggggagagg gcgagttcga cgaccgcatt ggctagtgga
     2041 atccgagctt caggtaagcc taggcggaga gctgcttgaa cagcagtcac tgctcgggca
     2101 gcaccggctg gattagctaa gccgatatct tcataagctg tcaccattaa gcgtcgacag
     2161 gctacttcta gctcaccagc gaccattagt cgagctaaat aatggagtga tgcatccaca
     2221 tcactgccac gaattgattt ttggaaggcg gagataacat catagtgagc atccccatcc
     2281 ttatcatggg tgagtgcttg gcgaccaata cattcttcag cgattgacaa ggtaatatga
     2341 atcgatccgt tagtgggagc agttgattca gccgccaatt ctaatgcatt caagctactt
     2401 cttaagtcac cgttcgttgc acgggcaaag tgtctgagtg ctgcttcatc cactgttagt
     2461 tccaaatgcc ctaatccatt cgtgtcatca tctagagcac ggtttagcgc tgagataata
     2521 tcagcttctt gcaaggggtt gagttcaaaa atctgacttc gacttcgaat agccgggtga
     2581 atggataagt atggattttc cgttgttgct ccaatcataa taatacgtcc actctctaag
     2641 tgtggcagga gaaaatcttg ttttggcttg tttaagcggt gaatttcatc aagaagcaaa
     2701 ataacagtcc cactcatttt ggcttcttct acgaccacat ttaagtcaga tttggattca
     2761 gtggctgcat tcagcattcg gaaggcatat ttggtcgaac ccgcaatggc gctggcgatg
     2821 ctggttttac caatacctgg gggaccatag agaatcatcg agctcagacg cttggcttcc
     2881 accattcgcc aaattatttt accttcaccg acaagatgtt gctgtccgac gacttcatca
     2941 atagattcgg gtcgcatgcg ataagctaag ggttgtttca tctgaattat cctttcttag
     3001 atagtcataa atcaaggttt aaaagttata tataactacc atcgggattg cgcaaggata
     3061 cttcagaact aatcaatgtc atcttttctt gcgatgagag atcgcgtacg agaagttctc
     3121 cggttgcttc aatgcctaac acctcaacat ctcggcgctt atctccctga acaacagtga
     3181 caatttcgcc tataaccgct gattcttgcc gacaaataga taaaaagggt tctggatcga
     3241 gggattgctg gtagtcttgg taaaattgtt caaaaatttt caaaaactgt gcaattaatt
     3301 tatctgcaaa aaaaagggac tccgtttcta aggcgagtga tgttgctttt gtatggattt
     3361 cagtggggaa gtctgactga gactgattca ggttaatccc aataccgatt gtaatagctt
     3421 gtaaaacttg gcgttcaaac atggcttcag ttaaaacgcc cgctactttt cgtcggttga
     3481 taagtaaatc attgggccat tttattgcta caggtagacc ggtttctgac agagcttgtt
     3541 gcagagcagc agccgttagt tgcgttaaga gagttggttt catctgagca gagaactcct
     3601 tcaacacgat gctgagagag agacttttac caataggact agaccatttt cgcccgcgac
     3661 gtccacgccc agctgtctga ctgtatgcta agagaacact gccatgatcg atggtcgata
     3721 agttattact aacatatgta tgcgtagaat caatcgtttc aaagagatat aacccctgag
     3781 tgccgaaagt ttgtgtgttg agataggtct taatgccagg gatggaatag agaggcgaag
     3841 ctaattggaa gccactattg tatgaatgaa tgacgagacc tagcgctcgc aattcttcca
     3901 ccgcttcggt aatctcagca gcagaacaat tgaattgttg acttagtgtt tctgttggta
     3961 cggggttagg gaattgttta tttaattgaa aaataagatg agaatgcata agaactcctt
     4021 ctaaattatg aaaattagtc agtctatgct ataattataa ggacgaaatg aactgtagtc
     4081 aatgaatatg agaatataga taaaagtaga tcaaataaag gagaattatt gtgtcaaatg
     4141 ttaaaattat ccccttaggt ggggttcgcg aaaatagtaa aagtttgtat gtggtggagg
     4201 tggacgccca aatattcgta ttagactgtg gattgatgtt cccagaaggt gaattatatg
     4261 gtatcgatgc cgtgattcct gacttcactt atttaaagca aaataaagag cgcattgccg
     4321 gcgtattttt atcacacggt catgaggatg cgataggagc gcttccgtac tttatcgatg
     4381 aattcaatgt gcctgtattc gggtctgagt tgacgattga gctggctcgc ttacaagttg
     4441 aatcagtgat tgggaaaggt aacttctctg attatcatgt tgtagattcc agtctggcga
     4501 ttgacttcgg tgaggtgaag gtgcatttct tccaagtgac gcacacgatt cctgatgcaa
     4561 tgggaatctc tattgaaaca ccagaaggac atgttgttta tacggggaac tttaagtttg
     4621 atcagagtgc agatggtccg taccgtacga acttaaacca tatttcagat attgggaaag
     4681 aacgcgttct agcgttgctc agttcatcgc tgggagcgga aagtcttgaa gagaatgcac
     4741 cagataaacg agttcaaagt gttgtgacag agatcttcca agatgcgccg actcgtatta
     4801 ttgtagcagc tgtccagagt aacttactgc gcatccagca aattattaat gcagcccacg
     4861 cgacgaatcg taaagtcttt atctctagct cgaaatccca agatattatt aatgtagcca
     4921 ttgacttagg aaaactaacg ttgccgaaaa aagacatctt acaatctata tcggacttgg
     4981 agaagttcca cgatgatgag actgttatct tggaaactgg ctcaagtgga gaaccgatta
     5041 aagctttacg cgagatggca actaatcaac atcctaacat tggtattcgc aatgaagata
     5101 ctgtctttat cgcgaccaac ccatcagtag cgatggaagt ggaagtggct gaatgtgaga
     5161 acttgattta tcgttcagga ggcgaagtgg tcaagttatc caaccaaatt aaggcaagtg
     5221 gacatgcaac accgaatgat ctgcaattga tgatgaactt acttcacccg gaatacttta
     5281 ttcccgtcca aggagagtac cgcgtcttag ccgcccacgc tcgcttagca catgagacag
     5341 gtattccaca cgaacatatt ttcaccttaa gcaatgggga tgttgtggag tacaaaaaag
     5401 gcaaaatgca cagtaccgga acggttccgg ctgataatac tttagttgac ggtataggta
     5461 ttggcgatgt gggcaatatt gtcttacgtg atcgtcgcct actatctaac gacggaattt
     5521 tcgtggctgt cgtaacgatt gaccgtcgca aacaaaagat tgttgccaag ccccacattg
     5581 ttacacgagg ctttgtcttt gtgaaagcta attatgacct tattaatgaa tcgactacaa
     5641 ttgtggaaaa agtgatccaa caaaacttga agcataatga tttcgattgg ggttcgatta
     5701 agtcagagat tcgcaatgaa ttgagcgatt acctctttaa agaaacgaaa cggcgcccaa
     5761 ttatcttacc ggttattatg gaagtgaacc aaagacgctg gtatgataaa taattgagga
     5821 ctgtttgtat cctataaaat atagtcaaag ggagagcgga gcttctaagt tagctctgct
     5881 cttatctaca taaaaaggag attaatatgt catatatctc aactattttt tggtggttta
     5941 taatcatcaa ctcgacctta gctatcttta ccatcttccg tgacaagacc cgtgatatag
     6001 cctcgatttg ggcatggctt ttagccctta ttatgctacc tggtattgga tttattgctt
     6061 atttgttctt cggtcgagga atgagtgata aagatattta cgatattaag caacaggatc
     6121 agattggatt acgcgaattg aaagacacct taaccgaacg atacgaacat caacatgaag
     6181 caagggatga agtattttct aataataaaa aggaaatggt ttctctgttc caaggattgg
     6241 ataatgcagc actaacccgt gataatgaag ttgatattta ttcggatggt aaggaaaagt
     6301 tcgatcagtt actggaagat attaagcaag ccaagcatca tattcatctc gtttattata
     6361 tttttcgagg ggataagatt ggtcgtgcca ttgtggatgc gctggaagag aaggccaatc
     6421 aaggtgtcga agtgcgtgtt ctatacgatc cggtgggtac tcggtggatg acgcgatcct
     6481 tttttaagaa attaaaatca ttcggtgggc aagcctgtcc atcattcggt gaacggatgc
     6541 atattttaaa tatgcgcttg aactatcgta atcaccgcaa aatagttgta attgatggaa
     6601 agattggcta cacgggaggc ttcaatgtcg gggatgatta cttaggagaa tatccggaaa
     6661 tgggttattg gcgtgacacg catgtccgaa ttgtcggtaa tggggtactc ccattgcaga
     6721 cccgcttttt aaccgattgg aatgcatcag ctgatgaggc acaacaagtt ccttacgata
     6781 accagtattt tcctattcaa gagacaacag gtgatgtcga tttgcaaatt gtctctagcg
     6841 gtccggatag caccgaacaa cagatcaaaa aaggctttat taagatgatc agcttagcac
     6901 gtgaatctgt ttatatccag acaccgtact tagtgccaga tgatgccgtg ttagagacga
     6961 ttgatatcgc ctctaagtca ggggtagagg ttcatgtcat gattccaaac aaaccggatc
     7021 atccctttat ttatcaggca acgttgagtt atgccgagca attagttgaa tacggcgctc
     7081 atgtgcatat ttacgatggg ggcttcttgc atgcgaagac tataattgta gatgatgaga
     7141 tgttaagtat cggaacagct aatttcgata tccgtagctt caagttgaac ttcgaagtta
     7201 ataccttcat gtatagtgaa aaactagccc aagcttatca tgctcaatat atgagtgact
     7261 tacaacatgc ttatgaatta acgccggata ttattgccaa ctactcactc tgggaacgct
     7321 tcaagcaaca attctctcgc ttattcagtc ctatcttata atatatacaa agctccgtat
     7381 catcattgtt tcgatgagta cggagttttc agtatgtata aacaaggatg ccccctgttg
     7441 atgtgtatca ttgggtacgt ttgatatttt caaatttttt gcctcgtgca agttcatcta
     7501 ttaatttgtc caagtagcga atattttgca ttagcggatc ttcgatatct tcaacacgtt
     7561 tcccacagat aactcctttg attaatgtac gatttggatg taacttaggc gcttggtcga
     7621 agaatttttc gaatgataca ttagcctcca attgttcatg caactcatct tggctgtagc
     7681 ctgttagcca acacatcagc tcatccactt gctcagcagt cttgcccttc ttctcagcct
     7741 tgttgacata atgcggatac accgcactca ccgccatatc aaaaatttta tgtcgtccca
     7801 taatgttacc atctcctttc tttctattct aacatacgaa actgacataa tataacaaac
     7861 taacatttgt ttcctaaatt agaagtattt agccgagttg ccgaaattac tcatagattt
     7921 agttgagtga tgtggtaaaa taaggctaga gatagcaacg acagacaagg agatgcttaa
     7981 catgaaccca gaatcacaac accaaaacct acaattgcaa ctgcaggaga caatcactca
     8041 cctggataag attaccgatc aactggaatc agccaaaaga tggtcgtggg cggatctgct
     8101 agggggtgaa tttatcacga gtatggtaaa gcgtaagaaa atgaaaaaca ttagcgaaga
     8161 cttacagcaa ctccaaccaa aactacagca cttgaagcac gcactggaag atgccaatat
     8221 tcaagttgat agcgccattg atcactcaac atcgcgtcag tttttcgata cgttcttcga
     8281 taacatcatc accgacttga aagtacaagg cgagatcaaa gacatgctgg cagaactcaa
     8341 agaactccgc caagcattga cgacgtatca acagcagatt gatagtggtg tctaatttag
     8401 aaaatatcta aaagtagcta gaaaaaagct agttgctttt tgtgactcaa tcattgatta
     8461 aaattccaaa agtatggtcc agtagaagaa tataacattg cctaatttac tcatgagcgc
     8521 cgatcgatgt atggggtaga atataactgt aataaaagga aatgcacggt ggcgattatt
     8581 gtaagaaaaa acaataaacc caaaggagtc ggtgtaaatg gaacaaagac aaagcgtggc
     8641 aattgagaca gaacagttag agttggttca agcagtatct gatgagaggt tagaagtgtt
     8701 ggtaggtggg aaaggccccg gactgttaaa gacacttaca aaagactgtc ctggtacagt
     8761 ttccgatgtt tgtgtaaatt tagcagttgt tagcacctgt aaaaaatgtg agtaaataga
     8821 gataaaaatg atatcgtgca taatcccacc agtaatatgg tgggtttcct tttttgatat
     8881 gcagaaagaa ttatacagaa aggactaaaa aatgaaaaca ctactaaaaa aagaattcaa
     8941 tacacacggg caaaataaat tattgtatat tgttctacta gtcgttggca taatgcaagt
     9001 gtttcttgcg agatcgttat ttggagcaga agggggagga gcactagcta aaacgatatt
     9061 tcaggacaac agcatcatct attctctagt agctacgata tttacgccga taatcgcggg
     9121 agttttgggt tattatttca tttcaagcga gttcgaacaa agaacttggg agatgtattt
     9181 tttaggcata aaaaacaagt caaaaatctt atggacaaag tatgtggtat gcttgttcta
     9241 ttggatagca tataatattt gcgtttgggg aatatttcta gggttatctg cattttattg
     9301 gcagcgtcaa gttgaccttt tttttgtttg gttgatccct attagcacta ctctattagg
     9361 actatttctg ttcacagcac aattgagtat gcatttttta atacccaata ctcaaatatc
     9421 aatttctata gtgatggtat ttattggaat tgttggaatg gttttagaat catggctaat
     9481 ttatgttttg ccattgtcat ccggatttta tttgaatcat atagatcaat ttaataattt
     9541 agagtatatg cgcttaatta ttcaaaatat tattttttca atcatcttaa tatctattgt
     9601 agttaaaaga ttccatttat aattaccttt tttactcatg atttttttga aaagtcacta
     9661 taaaatatat acggagtcat cgaagtcaca caaaaagaaa ggttgatata tcatggaaaa
     9721 atacaatgat gaaaataaga aagcacagaa aactgtcgag gttatcaaag acaaagaatt
     9781 agagcaaatg atcggtggag taggaccggg acttgttaga acactaacaa aagattgtcc
     9841 taatgttgtt ccaaaggttt gttttgatgg aaaatgtaag tattgtagat agagtaaagg
     9901 gttaacaatt aatcgatgac tttaggctct gtacaaataa gtgcagagca ttacatagaa
     9961 aaatgttcgt atgtaattgg atgttgaggg agtaatgata atggaagata cacaattgat
    10021 aaataaaaaa aatagttttg atcaagttat tgatgaaatt acaacttatt atttccagca
    10081 gataaaaatt gtaaatatct ttaatgtcaa cacaattaaa cagcaattat tagatgaagt
    10141 tagaaagtta tatttacctg cattagttga tgatatcaat cattatcgat taaatgttga
    10201 tgaatcttct acgccagaag aacagtatat gacgtattgc aggttgttta atagagaaaa
    10261 attaactgag ttgcatacaa agtacccgtt actggataaa tgggtacaca atacggtcga
    10321 aagatataag actaatttaa aattcttatc agatgcaatc gcaattgatt atgatgagat
    10381 cgttaaagta tttaacttat ctcaagaggc aaaagacaat atagaagtca tgtcatttgt
    10441 tggagatgtg catcatggca gccaagcaat tcaatttaaa ttagctggca aggaatttta
    10501 tcttaaaaga aatgggcaat tagtactaga gctagttgaa aaattgaaag agactattat
    10561 agcatcaagt caatttgatt tccctaagac atacttaggt gaacaatatt ttatccaaga
    10621 agcggtgcaa caagaaccat gtcaatcaga aggagatatt gctgattttt atttcaatat
    10681 gggaatgttg ttgtcatttg tctatatgtt aaatggaagt gatatgcaca acgaaaatgt
    10741 aatagctagt ggtaaaacac cgtatgtcgt ggatattgaa acattgatta atccagttga
    10801 tttttccaat gattcttgca ttgaacaaag tatcttccaa acggctatgc ttccaatgaa
    10861 gtataatcca acatttgaag gaatagttga ttgtagttca attggtgaag ttgtcacagt
    10921 aaggaagaaa atttttgaag cggaaaatcc atttagttca cgtattagat taaaactgaa
    10981 agatgtgtac tatgaggata ttgcaactca tctaccattg tatgatagtg aataccatag
    11041 tgttggtagt tatttgcata aagtagaaga gggatttaca gttggatata gaactattat
    11101 aggcaacaag aaaaacctaa taaatatcgt cgaacaatat agtgtagcag ttcaatgtcg
    11161 attagtgatg cggaatacca tagtttatag tgaattattg aagcgactta attctccaga
    11221 cttattggta tctatcagcc aatctcgaca atttctgcat cactttttat gggatattcg
    11281 ctacatcacc caaaataaac aagaatatat taatgaagaa attaatcagt tgttagaggg
    11341 agaagtacca tattttacgt atgggaacga aggaactatc ctgtcaaaag acgttgagtc
    11401 acttgcttca ataaaagaat cactgctaat gaagatcgaa caattttctg aagaagattt
    11461 gtcgtttcaa ttagatttac tgagagtagc attcaatata gataattaca attttacacg
    11521 tttgcagatg agtcatctga aagaatctgt gaatgacctt attcatgaat cgatatatga
    11581 tgagacgata ttgactattc agaaagatcc gaaaggtaat tatgtctata atgctattgg
    11641 gttaggcgta tatgaagggc agttaggact atggctcact gataaatgtt tccatcgaca
    11701 tatttcttat gatgatgtta taagagacat tattaacagt aaagatattg gtggaatcaa
    11761 tgggtatgca tcattatgtg tatgccaacg actattaggt cttccattat caaatgtaat
    11821 gattgatgag acaaagattg ctcaaataga tgtgattgat ggtttagcag ggttaatttt
    11881 ggtactttat agcgactaca gagaatctcc atcaaaaagc aagttgactc aattgattaa
    11941 tctacttgaa ctatttgaaa agaactataa tgttgatgag attaattgtt taggatttgc
    12001 ccatggtata tcggggataa aaattatctt ctatattatg agtcaattgc tagatacaac
    12061 ttttagagac aattacagag aaattgataa gttagataat tcagaagact acttatctgc
    12121 aacgtggtgc aatggcttga caggacattt aatagctgag tatattctgt ataaaatatc
    12181 tggtgatgca aaccacatga ataatgtgac taagcaacta cctaaactag ttcaattagc
    12241 atataacatg gatgattatt gcttgtgtca tgggctattt ggagtgttag actttttatt
    12301 aacagtgaaa agagaaggaa aactatcatc agatatgatt aggaaatatt acgaattaga
    12361 aagatatgca tacaggtatt tagatgaaca tgatgtattg agtaaggata tttcattatt
    12421 tacaggattg ggaggaatca gttattacct taatcgcaaa gagtctgata tcaaatcggt
    12481 gttaatgttt ggctactaaa agaaaggagc ttgcggttat gaagtatgtg ccagaaatta
    12541 tccagtttaa tcaaaatgat tgtggtccat gttgtttgtc catgttactc aattattatg
    12601 gttatgagtc agatatagaa gaattaactg aattgaaatc agcaatatat ggttggagca
    12661 tgttggatat aaagagaatt ggagaaaaat ttggattaga aagtaatgtt tacaatgtgc
    12721 agacaattca accattaaaa caagtgaaac tgccagctat tttgttttgg gaacattctc
    12781 atttcgttgt gttagagaag ataatagctg atgaaataat cattgttaac ccaagtgtgg
    12841 gcagacaaac agtcaacaaa aaagtatttt gggaaaagtt tacgggctat attatggaag
    12901 tttcgttagg gcaatcattt caaaagaaaa agattccttg gtatgataaa gtacagttat
    12961 atatgaataa agacatatgg aattttaaga taaaatggca gtatgtagca ttacttattg
    13021 tatatagtgc attgttattt atatcaccat tagctgttag cgaagtaatt agttcagtgg
    13081 ggctagatca tattccgtat gggaaaataa tggcattagt tggtgtagtt attgcgacag
    13141 gtatcactaa ttatttgtta gataagagaa gacaacgtga aaaattagac ttagaagaat
    13201 catcgacttt gaaattatat aacgaaatat caaaaaaatc gaaagtagaa ttttcgaaat
    13261 atcatagtgg cgatacttta tccagattac atgtaaacag tgatatttgt caatttatta
    13321 cgataggtat ccctaatatg ttactatcaa tcggattatt tatggtagta acaatctatt
    13381 tattgattag agtaggaatg atgtcactta ttttaagtgg agttatttta ctaatcgcat
    13441 taatcaatgg gttgttcatt gtaccattga tgaagatggc tcagactgag agttacaaat
    13501 tttcggattt tcgaacggta ttatcggatg ggatcatatc gcataattac ttcatcaatt
    13561 caggaattgg cggaacatat acggagaaag taactcatag tttgaaagat tatctcaatg
    13621 tttcttatga tcggtcaaag atagaggcaa aatcaaatac tgtacaacaa atgaccagta
    13681 cgttcttttc attgatatta tcggttttgg gaatggggct tatccttata ttccctaacg
    13741 atcgcagtaa tatatcattg ttaatgacaa cgggaatgat tctctattca ccagcgatgt
    13801 ctgtgttatc aactgtattg actgtatcga gagtagctcc gcatatgaaa cgattaaatg
    13861 aaatgataaa aaataaccag caaaactata caactaagag attgaaagac ggttcaataa
    13921 aggtaaaaga cttaaccttt caatacgaga atacagcgga tcctattata aacgatagaa
    13981 gtttcagatt gaaccatgga gaaaaattag ttatttgtgg tgaatcgggc agtggaaaaa
    14041 cgactttaat tgatttgtta ttaggattaa ataaacagta cgataaaggt gaggttgtgg
    14101 taggtggtgt gaatacaaag gaatatgatt tgaatttaaa agaagatgtg tgctatatta
    14161 cccaaccaac gaaattgttt aaagggactt tgaaagataa tttaaaatta tacttagatc
    14221 attatgatgt tgaacaatta attgaaataa cagctgatat ggagttagac acattgggta
    14281 gagagtgtga tttatcaaat catctcatat tagaagacgg gcttaatttt tcgcaaggtc
    14341 aaaaacaacg cttaggctta ttgcgactgt ttcttgggaa gtacaaaata attattgtag
    14401 atgaaccaac aagtaatctt gatgatagat tagcacgaaa aattttcagt atgattgatg
    14461 agctaaatac aaccaaaatt attattacac atgatgagaa gtatatacaa caagctgata
    14521 aagtactaaa tctaggagat gatgaacatg aatatcaagt ttaacaatgt caacaaaaca
    14581 tacgggcgta aacaggtctt gcaagatatt aacattacca ttccagaagg caagatttat
    14641 gggtttatcg gagcgaatgg tgcggggaaa acgacggcga tgaagatttt aaccggattg
    14701 acacctgcaa gcagtggcac agtcacattt gatgagaagg aattgaacca gctagagaat
    14761 aaggcaaaag cgtttggtgc ctttatcagt acgccgacgt attacaagaa tctaacggcg
    14821 tatgaaaact tagcaattat ccaagatgtc ttagaagaac ccaaagatga gattgatcgc
    14881 gtactggaga ttgttgggtt ggccgatgcg aagagtaaaa cgattgctga gtactcattt
    14941 ggaatgaagc aacggctggg attagcgttc tccttcttga atgatccgga tatcttgatt
    15001 ttagatgagc caacgaatgg acttgacccc aaaggtattg tggagattcg agaattactg
    15061 tattcattgt cgaaagagca agggaagaca atttttatct cgagtcataa tatttcagag
    15121 ttggagtcga ttgctgatat gattggcatt atccaaaatg gtaaattgat ttttgaagga
    15181 gagcttgatg aattatatgt aagtggcgaa agttcttact tattggagat agacgacatc
    15241 gatcaagcca agacagtgct tagcgaagaa ggcatttcat ttaccaacaa ggaacacaaa
    15301 ttccaaatta aatcgtctaa gcaacgtatt cctgaagtag ttaaagcatt gttagatcgt
    15361 gatattgcta tatttgagat aacaccgaac aagaacttag agcggatttt cttagattta
    15421 acggatggag atgacgaaca tgtggacact cattaaacat gaatttaaga cacatggcac
    15481 tcaaccgatc ttgtatttaa tattaggaat tatgggatta ctacaagttt ttctcacaac
    15541 aatcatgatt aaaacaacag atactgtatc gatacagggg agttatattc aaacagtttt
    15601 tcaaacaaac aatgcgatat ttctcagcaa ctcaattatt tttattttca gtgtaggtgc
    15661 tgtgatagga tactatataa tatcagtcga gtatcagaat aacacatggg agatgttact
    15721 attaggaaca ggtagtaaat caaaagtatt atgggccaag tatatcgtat ctaccttata
    15781 ttatcttagt tatcaggtat tgttttattc attgtttttg ttggtgcaat cgacatattt
    15841 caaccttcaa attgagatat cctttagcct attgatgcta gtatcgatta tgtttttatc
    15901 acttgtgcta tttacagcac agatagcgtg tcactactta attaaaaatg gcacaacggc
    15961 tattgcctgt gcagttggat tccttataat gcttgtgatt ttaccatcaa cagatttgtt
    16021 tagatatgtg atacggttat tgactccagg atatttagcg ggattagacg agtttagcgt
    16081 cacgggattt gtaagtgtcg ttgcattaaa catcatcgtt gcatctagca tgatgtcact
    16141 tgttgttaaa caattcaaat tataggaggc gaagcaaatg ttcttaaaac tggaattatt
    16201 gaaattcaaa cgaagaatta gtgttggtgc gttatgttta tttatgttgc tagttgtggg
    16261 acttcaaacg tttatagcga tgagaactcc agaattagag acgaatgtat tttatattgg
    16321 tagtttagaa tggtttagtg gaattatttt cccagcgttg gctcccgtgt ttattacgtt
    16381 atctgtttat gcagatacgg aatataaggg tatacaaaat tttgtgttaa aaggggttaa
    16441 accccagaaa ttatctcaat cgacgtggaa attcttcctt gttgcgttac ccttgctgta
    16501 tttaagttat gtgatgatac catttgtctt tatgtttttt cgaggaggcc taacaagtga
    16561 aggaatttgg tctgttgtga tatacagtgg tttgtccgtt atcagcattg tgtcacttgt
    16621 taatatcagt tttattatct acagaataac gatgaatgac tttttacctg tgattattgc
    16681 cgttgcgggt gtgatgttag cttttgcccc atttggacaa gatatgtggt tagttaatcc
    16741 gtatttatat atgtactaca gtgcgggaca tagtgggttt aattggtatc attatgccgt
    16801 tatcatagga ctttgtgcgg tcagtttcgc cgtgtatgcg tatgtaagct attataaaaa
    16861 gacaaaaagg gcgtaatcat gtggaaaagt ggacacccaa aatagatgtt atttaccaca
    16921 ttgtattttc agtattagct gtgtatttgt ttttaggcta taagggagtg tcttatctcc
    16981 ctcttatgat gagtttatgg ctgttattac tactttttga ttatatgatg atgacgatta
    17041 taggcgtgcg tacgcagatt gcccgactga ttgtctggac attccgactc gcacaggtgc
    17101 aatcaatatc attaatgaca actattcaac tgcctctcgt gatcagatat gtgttattaa
    17161 tgatgctgtt gaatttatta tgccaatgta tcactagttt attaacgcaa tatgtcgata
    17221 atcgtttatt gatgagacgc ttagggattg gcttagttgt tggtatcggt ttatggacgg
    17281 attatgccaa tattttgttc attgcttata ttgtttatgt gctgttttca accattttgg
    17341 caatcaaaca gcgaattaat caccatgtgt atactaaaaa taaacacaca ggttattggg
    17401 tactcgtcgc ggcgttttcg ttgcaattaa ttccactact cggactagtt atattggtgg
    17461 tgttgtctag tcagttattt actcaggtat ggttattttt tatggctgtt gcttcaacac
    17521 ttcttatgct aattgctggc tttaatcata aagctgttgt gggtcaggca tcgaaatggt
    17581 tgagcttaat attctgtact ttactctata tttatatttt tgtgcttatt ttagggttaa
    17641 atctaagttt agtgttattt atattatata ttatcgtaag tattatgtat atattgacat
    17701 taactgacgt atttggcaat catcaagtga atgctgtcag gttaattaaa cgggaagagg
    17761 ctctaaaaca agatttctcc aattatttac acgatgatgt tttgcaagat attaatgtat
    17821 tgatcaagat gacaacgttg gagccgtctg agaagacaca agcgttcttg cgggagcaac
    17881 tgtcagcttt aaatgatcaa ttgcgccagc agatgaatca gtatagtcca caattatcca
    17941 agcacttaac tttgcaagag aactatcgtc tgcttgtgag gtcactggaa cagacgtatc
    18001 cgaatcaagc tgtgtcgaca tctttttcga tgaatcggaa tttgacttta cctggaccgt
    18061 atgatgtgtt ggtttatcgg tggctcaggg agttgattca taatgtgtac aagcatgcag
    18121 gagcgagtca gttggatatt catgtggcag cgtacgatga gttgataatt gtgttggtgg
    18181 aagatgatgg gtgctttaag aagggctcac atcttgagat tggtcatggg ttgtacgtga
    18241 tccaagagca agtggaagca attggtggcc aactgtatat agaggcgaat cgtccacggg
    18301 ggttgcggat gcgggttgag ttcagtgtga tgggaggcga gataattgaa gattttgtta
    18361 attgatgatc ataagttatt ttcgcaaagt ttggcattag ttctagatca gacaacaagt
    18421 gatgtgcaag tggatatgat taatagtgaa ggggagttac ctgatgatct aagcgagttg
    18481 acagtatatg atgtgttagt gttggatatt aatttagata agggattcag tgaagatggg
    18541 ttcgagttgg cagaacgggt gcgtgctgta gcggtagatt tgccaatttt gatgttgact
    18601 ggttttgatt tgccggtcta tgaatatcag gcgcataaat tggaattaag tggatttgtc
    18661 aataaaaata ttggtaccga agatttattg agcctactca agcatgtgaa agatggtggg
    18721 cggcatttta caacggagaa ttggtttatt gatgagttga caccacgcga gcgagagttg
    18781 ttaggggcta tcgcgactgg gagaaagagg aaaataattg ctgaagaaat gtatatttct
    18841 gagcgcacgc tgaccaatca tatgcagagc attatggaca agctagaagt gaactccacg
    18901 attgaagcga tccagaaagc ccgggagtta ggttatttga agtgatcagt ggcgggagaa
    18961 agatgacttt tggggtatac ggatcttgcg ctttgaatga ttgcttgatt tactcatgca
    19021 ttgcgctgaa ttggggagta aactgggggt aggttagcta atggaggaga ttatgatgaa
    19081 atatgcaccg tatagtctgc tagccttagc aggtatatta gtttatctga cagtgaatcg
    19141 ctatattaca atgcacagca ttaatgtcgt tcccccgatt ggcgcaatct tgtgtgttat
    19201 tttctttttc gtctggcgca atcacttgaa acagcaaggg tattatgatg attaaataga
    19261 tgaagtctca gtgaaggtgc tgaggctttt ttattggagt agacttaaga taatatcaag
    19321 cagctgctgg gtgacttctt cgagtgtgtc taggggaatg gtggatagct ctaatagcaa
    19381 tgggaagtga tcactgtcaa gtgagttggg caggtggtgt cgttggcagg ttttgattaa
    19441 gtcacgcagg ttgatgtgat tagggagcgg cagatgtgtc ttgagagcgc gcggcggtag
    19501 gtagggtaag tgctggttaa ttgggtgatt ggcaacgata gagtggaaca gctctaattt
    19561 cgcactgtaa tgttggtgga gttgctttaa gtggctatcc agcatgcggt tgtcgatgag
    19621 atagagttgg gacgatttgt tggccggcag tgagttatcc aaaggtagat aattagtttg
    19681 tgtggtattg agatatttaa ttgaagtata aaaaaactat gaccaaagtg ttgtaaccgg
    19741 attctttaag tggtaaactg ttgttggaaa caaattaatg aaagtagaat gtaccgctgt
    19801 cgaacgatta attcaaagtg gtgttaatat caaacataaa cagttaccta agatatgttt
    19861 ttggttagga gttgttgtgt ttactgtagc cgtgctgctt ccaactgatt tattccaaag
    19921 catcacctgg attgagaaaa tacttggtga attaaaacca gtcggattag cgaccatatt
    19981 tttgttgcca attatcggga gtgtaggagt ggttgggtcc attatgaaca aatccgtctt
    20041 gtacggcagt ttgaatgttg cattgattct gtcattcccg ttgatgatat tggtttctaa
    20101 tattgtgcag gcattgtttt aaatgatcaa aaataagtta tccataaaag aaaaagaaaa
    20161 tattagattt tctctgaata atgtattacg aaggagagat aaggatgact attgtatcag
    20221 taagattgaa caaagaagaa gagaaagcga taaatagcta tgccacatta acgggatagc
    20281 cagtatcaca actgcttaaa caagcacttc ttagagagat tgaagacaag gtagattata
    20341 caattggagt agaagcgcta gaagaacacg agaaagatct acagacattt acgattgatg
    20401 aagtagctgg ggaactagga attgagttgt gagttgatcg tattagctct agcagttggg
    20461 cacggtaaag ctatttacaa gtagtaccag ttacaataaa aagacaagct atcagagaga
    20521 tgtctcagtg gcttgttttt ttaatatgtc aagttttgtc agtgagcaac tgactcatta
    20581 atagctgaac ttcttgggcg ccaatagtat cgccaccttg ttcaaataat tgaatcgctc
    20641 gcttgaaata tttccttgca agagacggct tgtgttgggc gacgcatatt tcacccatac
    20701 cacgctgagc gcatgcttga gcaattaaat catctgtttg ttctgcttgt gttaaacttt
    20761 gagccataaa agagactgct tcgtttagtt gttgcaattt cattcttaag tagccttgtt
    20821 cgtagttatt gacggactgt ttaagtaagt tattaggaaa gtgctgttca ataatacgtg
    20881 cttcttgttg aatcaattcc aatgcttgtc cgtaatcttc acgcatgcga tagaccatcg
    20941 ccagttgatg taatgctata tgttcttgtt ctatatcatg atttttacgg cttaattgta
    21001 gccactgttg gtaagtagat tcagctttat ctattttacc gtcttctaga tagatatagc
    21061 cgagtaagtt caatgcattg taatcagtcg ttgcttgttc atttatataa tcatcaacga
    21121 gttgtttggc ttttgggata tttccacgcg aaaattgtcc ccatgcttga tttatcattt
    21181 atttcactcc atttgtctat tgatttatta tactggattc agaataatat ttcgagtatt
    21241 tattaaaaat aattatttta ttataactat attatgttat aataaaatta ataaaaataa
    21301 ggaacaaaca tcaaaggcat ttattcctac aaaatttggt gaaagagcag ccttttacta
    21361 cggtgttgac tagatagaat caatattttt ttacaatctg attacttttg aaataacaaa
    21421 gtaatcagat tgtatttata gatagataga aagaagaatg agcaatgata aagaaaatat
    21481 ttgtcgtagt atctgttttt ttgactttag tattgttatt aacaggaata aattcacata
    21541 agcatcaact ggatttctca caatataagg cagttaatat atttggtatt caagaagatg
    21601 tacatgtagc tgatcgtgaa actgtaactg aacgattaga acaatttgct agggagcatg
    21661 atattgtgat tgctagacgt attgttgaac cgaatgaaac tggtgaagta ttttttacgt
    21721 atgatgtgta tggtcaaggt gacctccccg atgaattaga agtagcttca gaagaaagtg
    21781 caggaaaaag tgacctggcc aatagttatt taattgtctc aggtgaagtt gatacggagc
    21841 tgttgagaag tgaatttgat agtatgggat tcctagcgat tactagtgga gaagcttcgc
    21901 ctataaatct tattatgctt ttaatagcag aaatgtcaac gttaattagt tttgttatat
    21961 ttatattaac ctttgccgct ttaaccatca tctatcgagt aaaagattta aagttagcag
    22021 gcattcgatt gttagcagga gaatcttcat ggcaagtaac gctacgacca gtgaaagaag
    22081 atttgatcct aattgtatca tcatatgtga ttaatttgat gattggatta gtttctttat
    22141 tcgctcttga tcttgcaacc atgcttaata tcagtcttat agcaataggt ctgctggttc
    22201 ttcccctaat gtattcaggg atatcagtgg gcttgagtat aatttattta atgagtttga
    22261 gacgacatat gttagttgat ctacttaaag ggaaacttcc attgtaccgt ttaattagct
    22321 taatgttagt tggtcagatg atatcagtcg ttgtcgttgg atggagtatt aatgaaacga
    22381 ttgttgctac tagcaagtat caagaattat tatctggtca acagatttgg caaagcaatc
    22441 ctgatttagt gactttatca gctggaatgt cagcagatgg ggggaatgcc tccgaaagt
//
