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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP040414.1 (Dolosigranulum pigrum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | RiPP-like | 149,417 | 161,570 |
Region 2 | lanthipeptide-class-ii | 806,938 | 829,436 | Low | bovicin HJ50 | ribosomal:RiPP:Lanthipeptide
Region 3 | terpene-precursor | 1,141,076 | 1,161,966 |
Region 4 | lanthipeptide-class-ii | 1,231,711 | 1,254,455 |

NZ_CP040414.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 149,417 - 161,570 nt. (total: 12,154 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000500.5 |  | 0.42 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002700.2 |  | 0.42 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000624.3 |  | 0.42 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000558.5 |  | 0.48 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168
BGC0002579.2 |  | 0.48 | ribosomal | carnobacteriocin XY | Carnobacterium maltaromaticum
BGC0002674.2 |  | 0.46 | ribosomal | enterocin F4-9 | Enterococcus faecalis
BGC0000590.5 |  | 0.46 | ribosomal | microcin N | Escherichia coli
BGC0000617.5 |  | 0.44 | ribosomal | coagulin | Bacillus coagulans
BGC0002306.2 |  | 0.43 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000500.5 |  | 0.42 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0002700.2 |  | 0.42 | ribosomal | bacinapeptin | Bacillus nakamurai
BGC0000624.3 |  | 0.42 | ribosomal | salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide | Lactobacillus salivarius
BGC0000486.4 |  | 0.41 | ribosomal | butyrivibriocin AR10 | Butyrivibrio fibrisolvens

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
RpoN
Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 17.55 out of 18.46
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.93 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.30 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.35 out of 26.06
Confidence: medium
Additional weak hits (7):
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.62 out of 25.75
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 24.12 out of 28.14
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.79 out of 30.22
Confidence: weak
DosR
Description: Hypoxia stress response regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 20.35 out of 29.51
Confidence: weak
ANR
Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 20.06 out of 26.33
Confidence: weak
ClgR
Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.55 out of 30.22
Confidence: weak
NrdR
Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 21.66 out of 27.18
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes
RpoN | Regulator of nitrogen assimilation and virulence

NZ_CP040414.1 - Region 2 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 806,938 - 829,436 nt. (total: 22,499 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
FE331_RS04035: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001787.3 |  | 0.64 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000498.5 |  | 0.63 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000626.3 |  | 0.61 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000561.5 |  | 0.60 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000548.4 |  | 0.51 | ribosomal | salivaricin A | Streptococcus salivarius
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000521.3 |  | 0.49 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000547.5 |  | 0.49 | ribosomal | salivaricin 9 | Streptococcus salivarius

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0001787.3 |  | 0.64 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000498.5 |  | 0.63 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000626.3 |  | 0.61 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000561.5 |  | 0.60 | ribosomal | thermophilin 1277 | Streptococcus thermophilus
BGC0001210.5 |  | 0.52 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000548.4 |  | 0.51 | ribosomal | salivaricin A | Streptococcus salivarius
BGC0000528.5 |  | 0.51 | ribosomal | michiganin A | Clavibacter michiganensis subsp. michiganensis NCPPB 382
BGC0000539.5 |  | 0.50 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000521.3 |  | 0.49 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000547.5 |  | 0.49 | ribosomal | salivaricin 9 | Streptococcus salivarius

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage
Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for FE331_RS04035

FE331_RS04020
Leader:
MEQRQSVAIETEQLELVQAVSDERLEVLVGG
Core:
K G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
Core with dehydrations:
K G P G L L K Dhb L Dhb K D Cys P G Dhb V Dha D V Cys V N L A V V Dha Dhb Cys K K Cys E

#### antiSMASH-DB 4.0 matches for FE331_RS04020

100.0%
NZ_CP040409.1 and 4 others:
NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptide NZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptide NZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptide NZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide
Lanthipeptides: FE336_RS03450_lanthipeptide
1
K G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
K G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
1
K G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
58.8%
NC_017621.1 and 16 others:
NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptide NZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptide NZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptide NZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptide NZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptide NZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptide NZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptide NZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptide NZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptide NZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptide NZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptide NZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptide NZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptide NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptide NZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide
Lanthipeptides: SSUD12_RS06540_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C
33
G G +K T L T K D C P G +S+V C V N+ +S C K C
2
G S G F V K T L T K D C P G F L S N V C V N I G F I S G C K N C
33
58.8%
NZ_AQQB01000068.1 and 6 others:
NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptide NZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptide NZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptide NZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptide NZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptide NZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide
Lanthipeptides: K738_RS01000000110290_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C
33
G G L+K T L T K D C P G +S++C V N+ +S C K C
2
G S G L V K T L T K D C P G F L S N I C V N I G F I S G C K N C
33
with 44 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_CP040409.1 and 3 others:
NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptide NZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptide NZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide
Lanthipeptides: FE336_RS03460_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
G P G L++T L T K D C P V V C + C K C
2
G P G L V R T L T K D C P N V V P K V C F D----G N C K Y C R
30
50.0%
NZ_CP040414.1:
Lanthipeptides: FE331_RS04030_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
G P G L++T L T K D C P V V C + C K C
2
G P G L V R T L T K D C P N V V P K V C F D----G K C K Y C R
30
50.0%
NZ_JH792312.1 and 1 other:
NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide
Lanthipeptides: IIG_RS24665_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C
33
G P G ++T L T K D C P V C V + C K K C
2
G P G W V E T L T K D C P W N V P V A C V T I M G Q R I C K K C
33
50.0%
NZ_KB976165.1:
Lanthipeptides: ICC_RS24850_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
G P G ++T L T K D C P G C+ +A + C K K C
2
G P G W V E T L T K D C P G Y K P Y A C I T I A G Q T I C K K C R
34
47.1%
NZ_CM000731.1 and 2 others:
NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptide NZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide
Lanthipeptides: BCERE0020_RS28875_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C
33
G P G ++T L T K D C P C V + C K K C
2
G P G W V E T L T K D C P W K Q P A A C V I I M G Q K I C K K C
33
47.1%
NZ_CM000748.1 and 1 other:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide
Lanthipeptides: BTHUR0003_RS30910_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
G P G ++T L T K D C P + C V + C K K C
2
G P G W V E T L T K D C P W N M P V A C V T I M G Q R I C K K C R
34
47.1%
NZ_CM000758.1 and 1 other:
NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide
Lanthipeptides: BTHUR0013_RS15850_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
G P G + T L T K D C P C+ +A + C K K C
2
G P G W I A T L T K D C P A N K P Y A C I T I A G Q T I C K K C R
34
47.1%
NZ_CP036053.1 and 7 others:
NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptide NZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptide NZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptide NZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptide NZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptide NZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptide NZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide
Lanthipeptides: EXW64_RS27135_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C
33
G P G ++T L T K D C P C V + C K K C
2
G P G W V E T L T K D C P W K Q P G A C V I I M G Q K I C K K C
33
47.1%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide
Lanthipeptides: EXW47_RS29185_lanthipeptide
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C
33
G P G ++T+T K D C P V C V + C K K C
2
G P G W V E T V T K D C P W N V P V A C V T I M G Q R I C K K C
33
47.1%
NZ_CP058255.1:
Lanthipeptides: HW369_RS18920_lanthipeptide
6
L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
+ T+T K D C P T V S V C V +S C K C+
2
V P T I T K D C P N T V S S V C V T F P F I S A C K N C D
30

#### MIBiG 4.0 matches for FE331_RS04020

17.6%
BGC0000563.4 (AEA03263.1):
Lanthipeptide: venezuelin
4
G L L K T L T K D C P G
15
G L L L C G
7
G L L T L L N T V C I G
18
14.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
8
T L T K D C
13
T L T K+C
20
T L T K E C
25
8.8%
BGC0002144.3 (RCCGEPOP_RS37510):
LAP: phazolicin
28
S T C K K C E
34
+T C +C+
1
A T C A R C D
7
FE331_RS04030
Leader:
MEKYNDENKKAQKTVEVIKDKELEQMIGG
Core:
V G P G L V R T L T K D C P N V V P K V C F D G K C K Y C R
Core with dehydrations:
V G P G L V R Dhb L Dhb K D Cys P N V V P K V Cys F D G K Cys K Y Cys R

#### antiSMASH-DB 4.0 matches for FE331_RS04030

100.0%
NZ_CP040414.1:
Lanthipeptides: FE331_RS04030_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C F D G K C K Y C R
30
V G P G L V R T L T K D C P N V V P K V C F D G K C K Y C R
1
V G P G L V R T L T K D C P N V V P K V C F D G K C K Y C R
30
96.7%
NZ_CP040409.1 and 3 others:
NZ_CP040415.1 Lanthipeptides: FE330_RS03440_lanthipeptide NZ_CP040417.1 Lanthipeptides: FE328_RS00755_lanthipeptide NZ_CP040424.1 Lanthipeptides: FE321_RS03455_lanthipeptide
Lanthipeptides: FE336_RS03460_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C F D G K C K Y C R
30
V G P G L V R T L T K D C P N V V P K V C F D G C K Y C R
1
V G P G L V R T L T K D C P N V V P K V C F D G N C K Y C R
30
50.0%
NZ_CM000748.1 and 1 other:
NZ_JAIPUK010000011.1 Lanthipeptides: K9P71_RS26815_lanthipeptide
Lanthipeptides: BTHUR0003_RS30910_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C F----D G K C K Y C R
30
+G P G V T L T K D C P +P C C K C R
1
I G P G W V E T L T K D C P W N M P V A C V T I M G Q R I C K K C R
34
with 35 more sequence matches
Only the first 10 are displayed here.
50.0%
NZ_CM000758.1 and 1 other:
NZ_MOOT01000057.1 Lanthipeptides: BK765_RS20265_lanthipeptide
Lanthipeptides: BTHUR0013_RS15850_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C F----D G K C K Y C R
30
V G P G + T L T K D C P P C C K C R
1
V G P G W I A T L T K D C P A N K P Y A C I T I A G Q T I C K K C R
34
50.0%
NZ_CP040409.1 and 4 others:
NZ_CP040414.1 Lanthipeptides: FE331_RS04020_lanthipeptide NZ_CP040415.1 Lanthipeptides: allorf_0721024_0721203_lanthipeptide NZ_CP040417.1 Lanthipeptides: FE328_RS00745_lanthipeptide NZ_CP040424.1 Lanthipeptides: FE321_RS03445_lanthipeptide
Lanthipeptides: FE336_RS03450_lanthipeptide
2
G P G L V R T L T K D C P N V V P K V C F D----G K C K Y C R
30
G P G L++T L T K D C P V V C + C K C
2
G P G L L K T L T K D C P G T V S D V C V N L A V V S T C K K C E
34
50.0%
NZ_CP058255.1:
Lanthipeptides: HW369_RS18920_lanthipeptide
6
V R T L T K D C P N V V P K V C----F D G K C K Y C
29
V T+T K D C P N V V C F C K C
2
V P T I T K D C P N T V S S V C V T F P F I S A C K N C
29
50.0%
NZ_KB976165.1:
Lanthipeptides: ICC_RS24850_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C F----D G K C K Y C R
30
+G P G V T L T K D C P P C C K C R
1
I G P G W V E T L T K D C P G Y K P Y A C I T I A G Q T I C K K C R
34
48.5%
NC_017621.1 and 16 others:
NZ_CP039462.1 Lanthipeptides: E8M06_RS05390_lanthipeptide NZ_JABTZM010000032.1 Lanthipeptides: HRQ47_RS09675_lanthipeptide NZ_JAEVFQ010000010.1 Lanthipeptides: JNO64_RS06375_lanthipeptide NZ_JAFFHD010000003.1 Lanthipeptides: JN532_RS02075_lanthipeptide NZ_JAGFVG010000007.1 Lanthipeptides: J5581_RS04225_lanthipeptide NZ_JAIJZO010000001.1 Lanthipeptides: K5Q34_RS00965_lanthipeptide NZ_JAIMDS010000024.1 Lanthipeptides: K6V32_RS10650_lanthipeptide NZ_JAJUWV010000001.1 Lanthipeptides: LZF89_RS05505_lanthipeptide NZ_JAMDIS010000017.1 Lanthipeptides: M5P45_RS08180_lanthipeptide NZ_JAMYIU010000001.1 Lanthipeptides: NKE44_RS01780_lanthipeptide NZ_JAMYIX010000001.1 Lanthipeptides: NKE54_RS02675_lanthipeptide NZ_JAMYIY010000001.1 Lanthipeptides: NKE64_RS02785_lanthipeptide NZ_JAMYJP010000014.1 Lanthipeptides: NKE68_RS07350_lanthipeptide NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS03955_lanthipeptide NZ_VZMP01000023.1 Lanthipeptides: F6P50_RS09295_lanthipeptide NZ_VZNS01000007.1 Lanthipeptides: F6P79_RS05700_lanthipeptide
Lanthipeptides: SSUD12_RS06540_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C----F D G K C K Y C
29
G G V+T L T K D C P + V C F C K C
1
A G S G F V K T L T K D C P G F L S N V C V N I G F I S G C K N C
33
48.5%
NZ_AQQB01000068.1 and 6 others:
NZ_BCEY01000024.1 Lanthipeptides: GOZ53_RS05100_lanthipeptide NZ_BCEZ01000067.1 Lanthipeptides: GOZ55_RS11230_lanthipeptide NZ_BCFC01000053.1 Lanthipeptides: GOZ35_RS07920_lanthipeptide NZ_BCFG01000017.1 Lanthipeptides: GOZ50_RS03220_lanthipeptide NZ_BCFI01000009.1 Lanthipeptides: GOZ54_RS02495_lanthipeptide NZ_CP019557.1 Lanthipeptides: BZG42_RS05725_lanthipeptide
Lanthipeptides: K738_RS01000000110290_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C----F D G K C K Y C
29
G G L V+T L T K D C P + +C F C K C
1
A G S G L V K T L T K D C P G F L S N I C V N I G F I S G C K N C
33
41.2%
NZ_JH792312.1 and 1 other:
NZ_QNRN01000010.1 Lanthipeptides: DET63_RS17570_lanthipeptide
Lanthipeptides: IIG_RS24665_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C
21
G P G V T L T K D C P V P C
1
A G P G W V E T L T K D C P W N V P V A C
21
38.2%
NZ_CM000731.1 and 2 others:
NZ_CP043834.1 Lanthipeptides: F0362_RS30375_lanthipeptide NZ_NVOB01000050.1 Lanthipeptides: CON62_RS29235_lanthipeptide
Lanthipeptides: BCERE0020_RS28875_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C
21
G P G V T L T K D C P P C
1
A G P G W V E T L T K D C P W K Q P A A C
21
38.2%
NZ_CP036053.1 and 7 others:
NZ_JAOPRA010000024.1 Lanthipeptides: OCE16_RS27090_lanthipeptide NZ_KB976667.1 Lanthipeptides: IG5_RS06165_lanthipeptide NZ_LDKD02000003.1 Lanthipeptides: ABH17_RS27060_lanthipeptide NZ_NUAO01000019.1 Lanthipeptides: CN544_RS19345_lanthipeptide NZ_NVFH01000027.1 Lanthipeptides: COL40_RS24675_lanthipeptide NZ_NVHY01000021.1 Lanthipeptides: COM05_RS26660_lanthipeptide NZ_NVOV01000033.1 Lanthipeptides: CON78_RS26470_lanthipeptide
Lanthipeptides: EXW64_RS27135_lanthipeptide
1
V G P G L V R T L T K D C P N V V P K V C
21
G P G V T L T K D C P P C
1
A G P G W V E T L T K D C P W K Q P G A C
21
38.2%
NZ_CP036100.1 and 1 other:
NZ_CP072062.1 Lanthipeptides: J5V93_RS29280_lanthipeptide
Lanthipeptides: EXW47_RS29185_lanthipeptide
2
G P G L V R T L T K D C P N V V P K V C
21
G P G V T+T K D C P V P C
2
G P G W V E T V T K D C P W N V P V A C
21

#### MIBiG 4.0 matches for FE331_RS04030

16.7%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
8
T L T K D C
13
T L T K+C
20
T L T K E C
25
5.9%
BGC0002120.3 (NQE92413.1):
Lanthipeptide: nocathioamide A
15
N V V P K V C F D G K
25
N++ F D +
21
N I I D S S M F D D E
31
allorf_0825879_0825989
Leader:
MISGGRKMTFG
Core:
V Y G S C A L N D C L I Y S C I A L N W G V N W G
Core with dehydrations:
V Y G Dha Cys A L N D Cys L I Y Dha Cys I A L N W G V N W G

#### antiSMASH-DB 4.0 matches for allorf_0825879_0825989

100.0%
NZ_CP040409.1 and 4 others:
NZ_CP040414.1 Lanthipeptides: allorf_0825879_0825989_lanthipeptide NZ_CP040415.1 Lanthipeptides: allorf_0731332_0731442_lanthipeptide NZ_CP040417.1 Lanthipeptides: allorf_0172499_0172609_lanthipeptide NZ_CP040424.1 Lanthipeptides: allorf_0727752_0727862_lanthipeptide
Lanthipeptides: allorf_0745435_0745545_lanthipeptide
1
V Y G S C A L N D C L I Y S C I A L N W G V N W G
25
V Y G S C A L N D C L I Y S C I A L N W G V N W G
1
V Y G S C A L N D C L I Y S C I A L N W G V N W G
25

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 17.44 out of 18.16
Confidence: strong
PsrA
Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 21.21 out of 25.88
Confidence: medium
ArcA
Description: Repressor of carbon oxidation
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.05 out of 21.55
Confidence: medium
Additional weak hits (4):
HipB
Description: Bacterial antitoxin HipB
Species: Escherichia coli BL21(DE3)
Score: 23.05 out of 33.73
Confidence: weak
BldD
Description: Development and antibiotic global regulator
Species: Streptomyces coelicolor
Score: 19.25 out of 23.43
Confidence: weak
MatP
Description: Cell cycle regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 19.70 out of 25.75
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.32 out of 33.14
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

FE331_RS04020 - Class II
  Cleavage pHMM score: 0.20
  RODEO score: 0
  Monoisotopic mass: 3397.8 Da
  Molecular weight: 3400.0 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    3418.1 Da N = 1
    3436.1 Da N = 2
FE331_RS04030 - Class II
  Cleavage pHMM score: 4.30
  RODEO score: 0
  Monoisotopic mass: 3258.7 Da
  Molecular weight: 3260.9 Da
  Number of bridges: 2
allorf_0825879_0825989 - Class II
  Cleavage pHMM score: -6.80
  RODEO score: 0
  Monoisotopic mass: 2697.2 Da
  Molecular weight: 2699.1 Da
  Number of bridges: 2

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
ArcA | Repressor of carbon oxidation
PsrA | Oleic acid responsive regulator

NZ_CP040414.1 - Region 3 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,141,076 - 1,161,966 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
FE331_RS05480: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Hydrolases: peptidase
FE331_RS05525: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
FE331_RS05495: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.35 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.35 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
FE331_RS05495: PT_FPPS_like
Domain 1 (29 - 275): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  DMAPP, IPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06
Confidence: medium
Additional weak hits (3):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.23 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 19.12 out of 30.11
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
MogR | Repressor of flagellar motility genes

NZ_CP040414.1 - Region 4 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,231,711 - 1,254,455 nt. (total: 22,745 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Lyases: cyclase
FE331_RS05880: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000588.5 |  | 0.48 | ribosomal | microcin L | Escherichia coli
BGC0000521.3 |  | 0.47 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000547.5 |  | 0.46 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000504.5 |  | 0.45 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000501.3 |  | 0.44 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.44 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000500.5 |  | 0.44 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000496.5 |  | 0.44 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002698.2 |  | 0.50 | ribosomal | phaeornamide | Pseudophaeobacter arcticus DSM 23566
BGC0000588.5 |  | 0.48 | ribosomal | microcin L | Escherichia coli
BGC0000521.3 |  | 0.47 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis
BGC0000547.5 |  | 0.46 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0001210.5 |  | 0.45 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0000504.5 |  | 0.45 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000501.3 |  | 0.44 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000519.4 |  | 0.44 | ribosomal | labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3 | Actinomadura namibiensis
BGC0000500.5 |  | 0.44 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0000496.5 |  | 0.44 | ribosomal | AmfS | Streptomyces griseus subsp. griseus NBRC 13350

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for FE331_RS05880

FE331_RS05840
Leader:
MKKLSKFLTVVLAA
Core:
G T L A A C S N G A N D A A E E P A V D E P A V E E T V E D P A A D E T V D P A E D S A A D D A T D P A A D D A A D D K Q
Core with dehydrations:
G Dhb L A A Cys Dha N G A N D A A E E P A V D E P A V E E Dhb V E D P A A D E Dhb V D P A E D Dha A A D D A Dhb D P A A D D A A D D K Q

#### antiSMASH-DB 4.0 matches for FE331_RS05840

100.0%
NZ_CP040414.1:
Lanthipeptides: FE331_RS05840_lanthipeptide
1
G T L A A C S N G A N D A A E E P A V D E P A V E E T V E D P A A D E T V D P A E D S A A D D A T D P A A D D A A D D K Q
61
G T L A A C S N G A N D A A E E P A V D E P A V E E T V E D P A A D E T V D P A E D S A A D D A T D P A A D D A A D D K Q
1
G T L A A C S N G A N D A A E E P A V D E P A V E E T V E D P A A D E T V D P A E D S A A D D A T D P A A D D A A D D K Q
61
FE331_RS05905
Leader:
MNKNSRIDFKELERLSKFGG
Core:
A D N G A D N F G Q D R A V T P V V S A S L K F C A P A I S A V T T F L S C N R S C G W G C K K K K K
Core with dehydrations:
A D N G A D N F G Q D R A V Dhb P V V Dha A Dha L K F Cys A P A I Dha A V Dhb Dhb F L Dha Cys N R Dha Cys G W G Cys K K K K K

#### antiSMASH-DB 4.0 matches for FE331_RS05905

100.0%
NZ_CP040414.1:
Lanthipeptides: FE331_RS05905_lanthipeptide
1
A D N G A D N F G Q D R A V T P V V S A S L K F C A P A I S A V T T F L S C N R S C G W G C K K K K K
51
A D N G A D N F G Q D R A V T P V V S A S L K F C A P A I S A V T T F L S C N R S C G W G C K K K K K
1
A D N G A D N F G Q D R A V T P V V S A S L K F C A P A I S A V T T F L S C N R S C G W G C K K K K K
51
35.3%
NZ_JAQEHQ010000019.1 and 1 other:
NZ_JAQEHQ010000019.1 Lanthipeptides: PGR68_RS12855_lanthipeptide
Lanthipeptides: PGR68_RS12860_lanthipeptide
10
Q D R A V T P V V S A S L K F C A P A I S A V T T F L S C N R S C G
43
+ ++++ V V S A+L K C P A+S+V T S C N R+C G
7
E P Q S I S A V V S A T L K I C L P A V S S V T A L F S C N R T C G
40
27.5%
NZ_JACSPZ010000014.1:
Lanthipeptides: H9635_RS18390_lanthipeptide
15
T P V V S A---S L K F C A P A I S A V T T F L S C N R S C
42
T P++S A S K C A I S A++ +S N+ C
9
T P I L S A A T K S S K K C L G A I S A I S G L V S Y N K D C
39
with 9 more sequence matches
25.5%
NZ_FQZK01000006.1 and 2 others:
NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS32515_lanthipeptide NZ_FQZK01000006.1 Lanthipeptides: BUE45_RS32515_lanthipeptide
Lanthipeptides: BUE45_RS32515_lanthipeptide
9
G Q D R A V T P V V S A S L K F C A P A I S A V T--T F L S C N R S C G
43
G D R P + + C P + V T T +S C C G
3
G G D R P--P A T I S Y I T I C G P T M P V V T M L T V V S C G G G C G
37
23.5%
NZ_CP094446.1:
Lanthipeptides: L3476_RS23825_lanthipeptide
9
G Q D R A V T P V V S A S L K F C A P A I-S A V T T F L S C N R S C
42
G + V+ S K C A I S A++ +S N+ C
7
G T P A T I V S A V T R S S K P C I S A I G S A I S G I I S H N K D C
41
23.5%
NZ_KB976303.1 and 1 other:
NZ_KB976303.1 Lanthipeptides: IGY_RS26035_lanthipeptide
Lanthipeptides: IGY_RS26045_lanthipeptide
14
V T P V V S A S L K F C A P A I S A V T T F L S C N R S C
42
V V A S K C +S A++ L S N+ C
11
V I V V S R A S S K A C M S G V S A I S G L L S Y N K D C
39
21.6%
NZ_CP045729.1:
Lanthipeptides: allorf_1568662_1568871_lanthipeptide
3
N G A D N F G Q D R A V T P V V S A S L K F C A P A I S A V T
33
N G A++ Q + P+ A S C A +S A++
6
N G A E S-A Q T S P L I P I S K A S S V R C A K W V S A I S
35
19.6%
NZ_JHWP01000013.1:
Lanthipeptides: T535_RS0110485_lanthipeptide
14
V T P V V S A S L K F C A P A I S A V T T F L S C N R S C G
43
V+P V ++L + +V T+ +S +R C G
1
V S P A V V S A L T A I S G L S H S V T S H V S K H R K C G
30
17.6%
NZ_LT969517.1 and 1 other:
NZ_QVLV01000012.1 Lanthipeptides: DXC51_RS29565_lanthipeptide
Lanthipeptides: C1733_RS32195_lanthipeptide
24
F C A P A I S A V T T F L S
37
F A P A++A T F L S
21
F E A P A V T A S T G F L S
34
15.7%
NZ_KN125582.1:
Lanthipeptides: DJ91_RS27550_lanthipeptide
25
C A P A I S A V T T F L S C N R S C
42
C A I S A++ +S N+ C
22
C A S T I S A I S G L V S Y N K D C
39
13.7%
NZ_MSTN01000008.1 and 1 other:
NZ_MSTN01000008.1 Lanthipeptides: BVF97_RS19715_lanthipeptide
Lanthipeptides: BVF97_RS19720_lanthipeptide
13
A V T P V V S A S L K F C A P A
28
A V T P++ S+ C P+
10
A V T P L L G L S M A L C F P S
25
9.8%
NZ_BMRY01000001.1 and 16 others:
NZ_BNBJ01000011.1 Lanthipeptides: IE304_RS20740_lanthipeptide NZ_CP013738.1 Lanthipeptides: WQO_RS36570_lanthipeptide NZ_CP029361.1 Lanthipeptides: DIJ69_RS35105_lanthipeptide NZ_CP079114.1 Lanthipeptides: KV381_RS21260_lanthipeptide NZ_CP084357.1 Lanthipeptides: LEL86_RS33035_lanthipeptide NZ_CP090837.1 Lanthipeptides: LZ559_RS20475_lanthipeptide NZ_JALDPQ010000041.1 Lanthipeptides: MQC87_RS04410_lanthipeptide NZ_JAMFLF010000024.1 Lanthipeptides: M1212_RS34580_lanthipeptide NZ_KL573566.1 Lanthipeptides: BG84_RS1000000140120_lanthipeptide NZ_KZ819178.1 Lanthipeptides: DBP20_RS35670_lanthipeptide NZ_KZ819182.1 Lanthipeptides: DBP21_RS35710_lanthipeptide NZ_LIVT01000009.1 Lanthipeptides: AMK24_RS34305_lanthipeptide NZ_LIXK01000001.1 Lanthipeptides: AMK23_RS37735_lanthipeptide NZ_ML123117.1 Lanthipeptides: EES46_RS36000_lanthipeptide NZ_NNBN01000001.1 Lanthipeptides: CG717_RS33060_lanthipeptide NZ_WWGD01000043.1 Lanthipeptides: GTY72_RS37555_lanthipeptide
Lanthipeptides: IE140_RS05545_lanthipeptide
38
C N R S C G W G C
46
C R+C W C
1
C T R T C T W T C
9

#### MIBiG 4.0 matches for FE331_RS05905

11.8%
BGC0001155.5 (AGY49587.1):
Thiopeptide: GE2270
37
S C N R S C G W G C K
47
S C N C G+ C
1
S C N C V C G F C C S
11
7.8%
BGC0002130.3 (QKI29070.1):
Lanthipeptide: cacaoidin
37
S C N R S C G W G C
46
S + + W G C
14
S I S A T A S W G C
23
allorf_1238568_1238780
Leader:
MGAVQDMVMFS
Core:
S T K N L S T H T I I L R R S F D L L G Y F V A F H A I F G I S I Y A N Q F I Y G K I G V G H C G L S P I L L R G L I
Core with dehydrations:
Dha Dhb K N L Dha Dhb H Dhb I I L R R Dha F D L L G Y F V A F H A I F G I Dha I Y A N Q F I Y G K I G V G H Cys G L Dha P I L L R G L I

#### antiSMASH-DB 4.0 matches for allorf_1238568_1238780

100.0%
NZ_CP040414.1:
Lanthipeptides: allorf_1238568_1238780_lanthipeptide
1
S T K N L S T H T I I L R R S F D L L G Y F V A F H A I F G I S I Y A N Q F I Y G K I G V G H C G L S P I L L R G L I
59
S T K N L S T H T I I L R R S F D L L G Y F V A F H A I F G I S I Y A N Q F I Y G K I G V G H C G L S P I L L R G L I
1
S T K N L S T H T I I L R R S F D L L G Y F V A F H A I F G I S I Y A N Q F I Y G K I G V G H C G L S P I L L R G L I
59

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CcpA
Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 19.13 out of 20.97
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.71 out of 26.06
Confidence: medium
ZuR variant 1
Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 22.96 out of 28.19
Confidence: medium
Additional weak hits (3):
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.17 out of 32.74
Confidence: weak
FuR variant 2
Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.95 out of 32.74
Confidence: weak
NuR
Description: Nickel-responsive regulator
Species: Streptomyces coelicolor
Score: 23.78 out of 30.98
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

FE331_RS05840 - Class II
  Cleavage pHMM score: -2.90
  RODEO score: 0
  Monoisotopic mass: 5919.5 Da
  Molecular weight: 5922.8 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5940.9 Da N = 1
    5958.9 Da N = 2
    5976.9 Da N = 3
    5994.9 Da N = 4
    6012.9 Da N = 5
FE331_RS05905 - Class II
  Cleavage pHMM score: -4.00
  RODEO score: 0
  Monoisotopic mass: 5202.7 Da
  Molecular weight: 5205.9 Da
  Number of bridges: 4
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    5224.0 Da N = 1
    5242.0 Da N = 2
    5260.0 Da N = 3
    5278.0 Da N = 4
allorf_1238568_1238780 - Class II
  Cleavage pHMM score: -6.60
  RODEO score: 0
  Monoisotopic mass: 6376.6 Da
  Molecular weight: 6380.5 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    6398.5 Da N = 1
    6416.5 Da N = 2
    6434.5 Da N = 3
    6452.6 Da N = 4
    6470.6 Da N = 5
    6488.6 Da N = 6
    6506.6 Da N = 7

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CcpA | Catabolite control protein A
MogR | Repressor of flagellar motility genes
ZuR variant 1 | Zinc-responsive repressor