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Overview
1.1
1.2
1.3
1.4

### Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP040411.1 (Dolosigranulum pigrum)

Region | Type | From | To | Similarity Confidence | Most similar known cluster
--- | --- | --- | --- | --- | ---
Region 1 | RiPP-like | 344,187 | 354,483 |
Region 2 | terpene-precursor | 642,562 | 663,452 |
Region 3 | lanthipeptide-class-ii | 1,454,543 | 1,476,999 |
Region 4 | lanthipeptide-class-ii | 1,650,760 | 1,673,504 |

NZ_CP040411.1 - Region 1 - RiPP-like
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 344,187 - 354,483 nt. (total: 10,297 nt) Show pHMM detection rules used
RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
No tailoring functions detected.
Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | RiPP-like | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000571.3 |  | 0.36 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001787.3 |  | 0.36 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0001289.5 |  | 0.36 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000501.3 |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0001638.4 |  | 0.40 | ribosomal | klebsazolicin | Klebsiella pneumoniae subsp. ozaenae
BGC0001639.3 |  | 0.40 | ribosomal | klebsidin | Klebsiella pneumoniae
BGC0000571.3 |  | 0.36 | ribosomal | burhizin | Paraburkholderia rhizoxinica HKI 454
BGC0001787.3 |  | 0.36 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000551.5 |  | 0.36 | ribosomal | SapB | Streptomyces coelicolor A3(2)
BGC0001289.5 |  | 0.36 | ribosomal | penisin | Paenibacillus ehimensis
BGC0000513.3 |  | 0.36 | ribosomal | Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3 | Saccharopolyspora erythraea NRRL 2338
BGC0000501.3 |  | 0.35 | ribosomal | catenulipeptin | Catenulispora acidiphila DSM 44928
BGC0000504.5 |  | 0.35 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.83 out of 26.06
Confidence: strong
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.28 out of 26.06
Confidence: medium
Additional weak hits (3):
ArgR
Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.50 out of 20.01
Confidence: weak
PerR
Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.59 out of 28.14
Confidence: weak
ZuR variant 2
Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.87 out of 33.14
Confidence: weak
TFBS Finder
TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
MogR | Repressor of flagellar motility genes

NZ_CP040411.1 - Region 2 - terpene-precursor
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 642,562 - 663,452 nt. (total: 20,891 nt) Show pHMM detection rules used
terpene-precursor: (PT_FPPS_like and not PT_HPP)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Terpene
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: dehydrogenase
FE334_RS02960: 3-hydroxyisobutyrate dehydrogenase

smcogs
  SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

Hydrolases: peptidase
FE334_RS03005: methionine aminopeptidase

smcogs
  SMCOG1172: methionine aminopeptidase

Ligases: synthetase
FE334_RS02975: Polyprenyl synthetase

smcogs
  SMCOG1182: Polyprenyl synthetase

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | terpene-precursor | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.35 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0002397.2 |  | 0.47 | terpene | astallatene | Arabidopsis thaliana
BGC0002400.2 |  | 0.44 | terpene | boleracene | Brassica oleracea var. oleracea
BGC0002398.2 |  | 0.38 | terpene | (-)-ent-quiannulatene | Arabidopsis thaliana
BGC0000641.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC416
BGC0000639.3 |  | 0.38 | terpene | carotenoid | Enterobacteriaceae bacterium DC260
BGC0000642.3 |  | 0.37 | terpene | carotenoid | Enterobacteriaceae bacterium DC413
BGC0001456.3 |  | 0.36 | terpene | isorenieratene | Streptomyces argillaceus
BGC0001605.3 |  | 0.35 | terpene | gibberellin | Sinorhizobium fredii NGR234
BGC0000665.5 |  | 0.35 | other (other), terpene | xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C | Streptomyces sp. HKI0576
BGC0000527.5 |  | 0.34 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Detailed terpene predictions
Detailed information for terpene domains. Shows possible products of a terpene cluster and lists the subtype and expected reactions for each terpene-related domain.
Product predictions:

Class | Subclass | Product name | Chain length | Initial cyclisations | Functional groups
--- | --- | --- | --- | --- | ---
sesquiterpene precursor |  | FPP | C15 | acyclic | PP

Genes with terpene domains:
FE334_RS02975: PT_FPPS_like
Domain 1 (29 - 275): Prenyltransferase; Farnesyl diphosphate synthase like
Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:
  IPP, DMAPP → FPP

Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
CRP
Description: Cyclic AMP receptor protein
Species: Escherichia coli str. K-12 substr. MG1655
Score: 17.13 out of 19.26
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.28 out of 26.06
Confidence: medium
MogR
Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.97 out of 26.06
Confidence: medium
Additional weak hits (2):
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.81 out of 30.11
Confidence: weak
CelR
Description: Cellobiose uptake repressor
Species: Streptomyces coelicolor
Score: 20.23 out of 30.11
Confidence: weak
Terpene
TFBS Finder
Glossary
Glossary showing acronyms and their full names.

Acronym | Full name
--- | ---
DMAPP | Dimethylallyl diphosphate
FPP | Farnesyl diphosphate
IPP | Isopentenyl diphosphate
PP | Diphosphate

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
CRP | Cyclic AMP receptor protein
MogR | Repressor of flagellar motility genes

NZ_CP040411.1 - Region 3 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,454,543 - 1,476,999 nt. (total: 22,457 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
TFBS Finder
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Hydrolases: glucosidase hydrolase
FE334_RS06785: alpha/beta hydrolase domain-containing protein

smcogs
  SMCOG1066: alpha/beta hydrolase domain-containing protein

FE334_RS06860: Alpha-glucosidase

smcogs
  SMCOG1257: Alpha-glucosidase

Lyases: cyclase
FE334_RS06815: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.58 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.52 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000539.5 |  | 0.52 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002005.2 |  | 0.52 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000500.5 |  | 0.50 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001787.3 |  | 0.49 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000626.3 |  | 0.49 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000498.5 |  | 0.49 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000504.5 |  | 0.58 | ribosomal | cytolysin ClyLl, cytolysin ClyLs | Plasmid pAD1
BGC0000554.4 |  | 0.52 | ribosomal | SRO15-3108 | Streptomyces filamentosus NRRL 15998
BGC0000539.5 |  | 0.52 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0002005.2 |  | 0.52 | ribosomal | RaxX | Xanthomonas oryzae pv. oryzae
BGC0000525.5 |  | 0.51 | ribosomal | lichenicidin VK21 A1, lichenicidin VK21 A2 | Bacillus licheniformis
BGC0000500.5 |  | 0.50 | ribosomal | carnolysin A1, carnolysin A2 | Carnobacterium maltaromaticum
BGC0001787.3 |  | 0.49 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000626.3 |  | 0.49 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000498.5 |  | 0.49 | ribosomal | bovicin HJ50 | Streptococcus equinus
BGC0000558.5 |  | 0.49 | ribosomal | sublancin 168 | Bacillus subtilis subsp. subtilis str. 168

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.

#### Lanthipeptide(s) for FE334_RS06815

FE334_RS06825
Leader:
MKNKVNNWKTPVYEKEEDYDNPAGDIFRELKSDDIDKVMASG
Core:
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
Core with dehydrations:
Dhb A N Dhb Y Cys R Cys Y Dha G R H Dha Cys G R A Cys Dhb I Dhb A E Cys P V F Dhb V A Cys Cys

#### antiSMASH-DB 4.0 matches for FE334_RS06825

100.0%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: FE334_RS06825_lanthipeptide NZ_CP040422.1 Lanthipeptides: FE323_RS09430_lanthipeptide NZ_JH601103.1 Lanthipeptides: HMPREF9703_RS02710_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: B8A46_RS06295_lanthipeptide
Lanthipeptides: FE336_RS08590_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
73.5%
NZ_JADNMH010000005.1:
Lanthipeptides: I2E99_RS07105_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N T Y C C Y S G+ S C G R C T I T E C P+ T V C C
2
T A N T Y C H C Y S G K D S C G R R C T I T T E C P I A T V V C C
34
73.5%
NZ_JADPCZ010000011.1 and 1 other:
NZ_OW659477.1 Lanthipeptides: NMG62_RS06660_lanthipeptide
Lanthipeptides: I4W03_RS06785_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N T Y C C Y S G+H S C G R A C T+T E C P+ T+ C C
2
T A N T Y C H C Y S G K H S C G R A C T V T T E C P I A T I I C C
34
with 79 more sequence matches
Only the first 10 are displayed here.
69.7%
NC_011900.1 and 2 others:
NZ_NCVD01000002.1 Lanthipeptides: B7702_RS00350_lanthipeptide NZ_NCVL01000015.1 Lanthipeptides: B7694_RS04515_lanthipeptide
Lanthipeptides: SPN23F_RS06435_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A +Y C C Y S G H S C G R C T I T E C P T C C
1
T A R S Y C A C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
69.7%
NZ_CP102135.1:
Lanthipeptides: NQZ98_RS01500_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A +Y C C Y S G H S C G R C T I T E C P T C C
1
T A R S Y C G C Y S G E H S C G R G C T I T T E C P F L T F I C C
33
69.7%
NZ_FQTY01000002.1:
Lanthipeptides: BUB33_RS04605_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N+Y C C Y S + S C G C T I T E C P V T V C C
1
T A N S Y C H C Y S N K D S C G H G C T I T T E C P V A T V I C C
33
67.6%
NZ_LR595858.1:
Lanthipeptides: FQT45_RS03330_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N+Y C C Y S G+ S C G R C T I T E C P+ T+ C C
2
T A N S Y C H C Y S G K D S C G R G C T I T T E C P I A T I I C C
34
66.7%
NZ_JVCZ01000028.1:
Lanthipeptides: ADG88_RS11420_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A +Y C C Y S G +S C G R C T I T E C P T C C
1
T A R S Y C A C Y S G E N S C G R G C T I T T E C P F L T F I C C
33
64.7%
NZ_GG666304.1:
Lanthipeptides: HMPREF0077_RS09155_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N T+C C Y S G+ S C G C T I T E C P T+ C C
2
T A N T H C H C Y S G K D S C G H G C T I T T E C P F A T L I C C
34
64.7%
NZ_JAESIP010000017.1 and 3 others:
NZ_LT907978.1 Lanthipeptides: EHLA_RS12685_lanthipeptide NZ_QRYY01000029.1 Lanthipeptides: DWW21_RS18370_lanthipeptide NZ_SPFW01000044.1 Lanthipeptides: FGQ81_RS16590_lanthipeptide
Lanthipeptides: JMK14_RS12260_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C C
33
T A N T+C C Y S S C G R C T T A E C P+ T+ C C
2
T A N T H C N C Y S E D A S C G R L C T G T A E C P I M T I I C C
34
47.1%
NZ_LMFO01000023.1:
Lanthipeptides: allorf_629531_629758_lanthipeptide
1
T A N T Y C R C Y S G R H S C G R A C T I T A E C P V F T V A C
32
+ N T Y C Y S + S C G C T T E C P + C
3
S P N T Y N S C Y S K Q K S C G N F C T F T T E C P F L S F C C
34
36.4%
NZ_CP043317.1 and 1 other:
NZ_CP043317.1 Lanthipeptides: FYC74_RS17680_lanthipeptide
Lanthipeptides: FYC74_RS17680_lanthipeptide
1
T A N T Y C R C Y S-G R H S C G R A C T I T A E C
25
T N T+ S G H G C T+T E C
2
T T N T F S L S D S L G N H--G G W C T L T K E C
25
36.4%
NZ_JAQDBP010000004.1 and 18 others:
NZ_JAQDBP010000004.1 Lanthipeptides: PGY07_RS07085_lanthipeptide NZ_JAQEAL010000002.1 Lanthipeptides: PGU65_RS02165_lanthipeptide NZ_JAQESL010000010.1 Lanthipeptides: PG840_RS09145_lanthipeptide NZ_JAQEUC010000007.1 Lanthipeptides: PG788_RS06860_lanthipeptide NZ_QRHW01000005.1 Lanthipeptides: DW641_RS05035_lanthipeptide NZ_QROS01000011.1 Lanthipeptides: DW021_RS13630_lanthipeptide NZ_QRPQ01000001.1 Lanthipeptides: DWZ74_RS02490_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QRZZ01000003.1 Lanthipeptides: DWV87_RS03165_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSJW01000012.1 Lanthipeptides: DW767_RS16350_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QSKF01000004.1 Lanthipeptides: DW740_RS06305_lanthipeptide NZ_QTZB01000014.1 Lanthipeptides: DXC15_RS13895_lanthipeptide NZ_QUCI01000011.1 Lanthipeptides: DW648_RS10830_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUJJ01000004.1 Lanthipeptides: DW748_RS03630_lanthipeptide NZ_QUKU01000006.1 Lanthipeptides: DXC27_RS05470_lanthipeptide
Lanthipeptides: PGY07_RS07085_lanthipeptide
14
S C G R A C T I T A E C-P V F T V A C C
33
S G C T I+ E C +F T+A C C
12
S S G V V C T I S V E C G S I F T L A C C
32

#### MIBiG 4.0 matches for FE334_RS06825

18.2%
BGC0000517.4 (BAB04173.1):
Lanthipeptide: haloduracin β or haloduracin α
16
G R A C T I T A E C
25
G C T+T E C
14
G A Y C T L T V E C
23
18.2%
BGC0002110.3 (QKV49893.1):
Lanthipeptide: birimositide
16
G R A C T I T A E C
25
G C T+T E C
16
G G W C T L T K E C
25
10.3%
BGC0001229.4 (SBI_06990):
Lanthipeptide: SBI-06990 A1 or SBI-06989 A2
19
C T I T A E C
25
C T++ E C
28
C T L S K E C
34
allorf_1455891_1455998
Leader:
MSFDRVVSAS
Core:
S R R S I L C G V S F L F I L G K I K T I S Q K E
Core with dehydrations:
Dha R R Dha I L Cys G V Dha F L F I L G K I K Dhb I Dha Q K E

#### antiSMASH-DB 4.0 matches for allorf_1455891_1455998

100.0%
NZ_CP040409.1 and 4 others:
NZ_CP040411.1 Lanthipeptides: allorf_1455891_1455998_lanthipeptide NZ_CP040412.1 Lanthipeptides: allorf_1876575_1876682_lanthipeptide NZ_CP040422.1 Lanthipeptides: allorf_2017756_2017863_lanthipeptide NZ_CP040939.1 Lanthipeptides: allorf_0419830_0419937_lanthipeptide
Lanthipeptides: allorf_1849829_1849936_lanthipeptide
1
S R R S I L C G V S F L F I L G K I K T I S Q K E
25
S R R S I L C G V S F L F I L G K I K T I S Q K E
1
S R R S I L C G V S F L F I L G K I K T I S Q K E
25
17.5%
NZ_JAFHCX010000012.1 and 1 other:
NZ_LR738722.1 Lanthipeptides: STREPSUIS_RS04075_lanthipeptide
Lanthipeptides: JXW96_RS06965_lanthipeptide
9
V S F L F I L G K I K T I
21
V S F F +G +K T+
24
V S F A F S V G V V K T V
36
allorf_1471108_1471185
Leader:
MRVAMTGS
Core:
F S Y R H I C C G V F L I N K I M
Core with dehydrations:
F Dha Y R H I Cys Cys G V F L I N K I M

#### antiSMASH-DB 4.0 matches for allorf_1471108_1471185

100.0%
NZ_CP040409.1 and 6 others:
NZ_CP040411.1 Lanthipeptides: allorf_1471108_1471185_lanthipeptide NZ_CP040412.1 Lanthipeptides: allorf_1893493_1893570_lanthipeptide NZ_CP040422.1 Lanthipeptides: allorf_2032974_2033051_lanthipeptide NZ_CP040939.1 Lanthipeptides: allorf_0436749_0436826_lanthipeptide NZ_JH601103.1 Lanthipeptides: allorf_0572098_0572175_lanthipeptide NZ_NAQX01000046.1 Lanthipeptides: allorf_46890_46967_lanthipeptide
Lanthipeptides: allorf_1865049_1865126_lanthipeptide
1
F S Y R H I C C G V F L I N K I M
17
F S Y R H I C C G V F L I N K I M
1
F S Y R H I C C G V F L I N K I M
17
11.9%
NZ_JAGPXN010000019.1:
Lanthipeptides: allorf_013625_013804_lanthipeptide
2
S Y R H I C C G V F L
12
+ R++C C G+ L
31
A R R Y L C C G L R L
41

#### Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine
Transcription Factor Binding Sites
Detailed information for Transcription Factor Binding Site hits, including surrounding genes where applicable.
The strand of the match is shown by an arrow underneath the match.
Detailed documentation is available here.
Binding sites found:
AbrC3
Description: Antibiotic production activator
Species: Streptomyces coelicolor
Score: 16.05 out of 18.16
Confidence: strong
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.88 out of 27.78
Confidence: medium
CodY
Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.19 out of 27.78
Confidence: medium
CatR
Description: H2O2-responsive repressor
Species: Streptomyces coelicolor
Score: 21.97 out of 25.31
Confidence: strong
DasR
Description: N-acetylglucosamine dependent repressor
Species: Streptomyces coelicolor
Score: 24.72 out of 27.04
Confidence: strong
Additional weak hits (1):
DmdR1
Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 23.09 out of 36.53
Confidence: weak
Lanthipeptides
TFBS Finder
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.

FE334_RS06825 - Class II
  Cleavage pHMM score: -5.60
  RODEO score: 0
  Monoisotopic mass: 3420.5 Da
  Molecular weight: 3422.9 Da
  Number of bridges: 7
allorf_1455891_1455998 - Class II
  Cleavage pHMM score: -6.20
  RODEO score: 0
  Monoisotopic mass: 2732.6 Da
  Molecular weight: 2734.3 Da
  Number of bridges: 1
  Alternative weights
    (assuming N unmodified Ser/Thr residues)
    2752.3 Da N = 1
    2770.3 Da N = 2
    2788.3 Da N = 3
    2806.4 Da N = 4
allorf_1471108_1471185 - Class II
  Cleavage pHMM score: -5.70
  RODEO score: 0
  Monoisotopic mass: 2025.0 Da
  Molecular weight: 2026.5 Da
  Number of bridges: 1

TFBS definitions
Shows descriptions for Transcription Factor Binding Site models

Regulator | Description
--- | ---
AbrC3 | Antibiotic production activator
CatR | H2O2-responsive repressor
CodY | Regulator of stationary phase and virulence in Gram-positive bacteria
DasR | N-acetylglucosamine dependent repressor

NZ_CP040411.1 - Region 4 - lanthipeptide-class-ii
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
More detailed help is available here.
Download region GenBank file
Download region SVG
Location: 1,650,760 - 1,673,504 nt. (total: 22,745 nt) Show pHMM detection rules used
lanthipeptide-class-ii: cds(LANC_like and DUF4135)

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
binding site
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
Gene overview
Tailoring
MIBiG comparison
KnownClusterBlast
SubClusterBlast
Lanthipeptides
Gene/CDS overview
A brief tabular summary of genes/CDS features within the region.
Filtering the table will also search biosynthetic profiles and gene function data. If enabled, the overview will then zoom to show the area covered by the filtered selection.
Genes selected in the region drawing above will be marked in the table with an indicator to the left of the gene name.
Filter:
Automatically zoom to filtered/selected features

Identifier | Product | Length | Function | Sequence | NCBI Blast | Filter details
--- | --- | --- | --- | --- | --- | ---
|  | NT | AA |  | NT | AA |  |

No genes match the given filter
Tailoring functions
Tailoring enzymes detected in this region
Oxidoreductases: oxidoreductase
FE334_RS07770: oxidoreductase

smcogs
  SMCOG1079: oxidoreductase

Lyases: cyclase
FE334_RS07795: lanthionine synthetase C family protein

smcogs
  SMCOG1070: lanthionine synthetase C family protein

Ligases: synthase
FE334_RS07845: 3-oxoacyl-(acyl carrier protein) synthase III

smcogs
  SMCOG1084: 3-oxoacyl-(acyl carrier protein) synthase III

Similar gene clusters
Shows areas that are similar to the current region to a reference database.
Mouseover a score cell in the table to get a breakdown of how the score was calculated.The MIBiG database.
Click on an accession to open that entry in the MIBiG database.
Analysis type:

Reference | lanthipeptide-class-ii | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000526.5 |  | 0.44 | ribosomal | macedocin | Streptococcus macedonicus
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001787.3 |  | 0.43 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000626.3 |  | 0.43 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000527.5 |  | 0.43 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000539.5 |  | 0.42 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000547.5 |  | 0.42 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000521.3 |  | 0.42 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Reference | Aggregated | Similarity score | Type | Compound(s) | Organism
--- | --- | --- | --- | --- | ---
BGC0000526.5 |  | 0.44 | ribosomal | macedocin | Streptococcus macedonicus
BGC0001226.4 |  | 0.44 | ribosomal | streptocollin | Streptomyces collinus Tu 365
BGC0001210.5 |  | 0.44 | ribosomal | pseudomycoicidin | Bacillus pseudomycoides DSM 12442
BGC0001787.3 |  | 0.43 | ribosomal | suicin 3908 | Streptococcus suis
BGC0000626.3 |  | 0.43 | ribosomal | thuricin | Bacillus thuringiensis
BGC0000527.5 |  | 0.43 | ribosomal | mersacidin | Bacillus sp. HIL-Y85/54728
BGC0002306.2 |  | 0.42 | ribosomal | freyrasin | Paenibacillus polymyxa ATCC 842
BGC0000539.5 |  | 0.42 | ribosomal | nukacin ISK-1 | Staphylococcus warneri
BGC0000547.5 |  | 0.42 | ribosomal | salivaricin 9 | Streptococcus salivarius
BGC0000521.3 |  | 0.42 | ribosomal | lacticin 481 | Lactococcus lactis subsp. lactis

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.

No significant matches found.

Similar subclusters
Shows sub-cluster units that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.

No significant matches found.

Lanthipeptide predictions
Shows the possible core peptides for each biosynthetic enzyme.
Includes CompaRiPPson results for any available databases, with a detailed explanation here.
Lanthipeptides - No core peptides found.
Lanthipeptides
Core peptide predictions
Lists the possible core peptides in the region. Each core peptide lists the number of lanthionine bridges, possible molecular weights, and the scores for cleavage site prediction and RODEO.
No core peptides found.