LOCUS       NZ_JAGFWR010000046      9182 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Micromonospora antibiotica strain MMS20-R2-23 contig46, whole genome
            shotgun sequence.
ACCESSION   NZ_JAGFWR010000046
VERSION     NZ_JAGFWR010000046.1
KEYWORDS    WGS; RefSeq.
SOURCE      Micromonospora antibiotica
  ORGANISM  Micromonospora antibiotica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 9182)
  AUTHORS   Lee,D.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2021) Microbiology & Molecular Biology, Chungnam
            National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, South
            Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 79.63x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017599305.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 02:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,561
            CDSs (total)                      :: 6,498
            Genes (coding)                    :: 6,378
            CDSs (with protein)               :: 6,378
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 20 of 120
            Pseudo Genes (incomplete)         :: 107 of 120
            Pseudo Genes (internal stop)      :: 2 of 120
            Pseudo Genes (multiple problems)  :: 9 of 120
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:14:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 0
            Orig. end                         :: 9182
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAGFWR010000046.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     gene            <1..2925
                     /locus_tag="JQN83_RS32350"
                     /old_locus_tag="JQN83_32345"
     CDS             <1..2925
                     /NRPS_PKS="Domain: PKS_DH (51-215). E-value: 1.5e-58.
                     Score: 189.8. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32350_PKS_DH.1"
                     /NRPS_PKS="Domain: PKS_KR (532-712). E-value: 1.6e-57.
                     Score: 186.4. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32350_PKS_KR.1"
                     /NRPS_PKS="Domain: PKS_PP (806-890). E-value: 1.4e-28.
                     Score: 91.1. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32350_PKS_PP.1"
                     /NRPS_PKS="Domain: PKS_Docking_Cterm (899-971). E-value:
                     3.7e-22. Score: 71.0. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32350_PKS_Docking_Cterm.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018729034.1"
                     /locus_tag="JQN83_RS32350"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_32345"
                     /product="type I polyketide synthase"
                     /protein_id="WP_307800017.1"
                     /sec_met_domain="adh_short (E-value: 8.3e-64, bitscore:
                     202.4, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.7e-15, bitscore:
                     45.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FVAGVEVDWRRVVGAGRLVDVPTYAFQGERYWLEAPRNTGDLSAA
                     GLDQAGHPMLGAAVVLAGDAGTLFTGRVSLTTHPWLADHLVGGTVLLPGAAFVDLALHC
                     AAYAGLAMVDDLTLHAPLALPAHGVVDLQVVASAPDDTGRRRVTIHGRSADTDSGQDWT
                     LHASGVLTPVADPAGTALTSWPPAGVVPVDLTGLYDRLAEHGYGYGTAFRGLTGLWRDP
                     DHCYAEITLPEGTDPTGHRLHPALLDAALHPLLALALADNDGPLPLRIPFSWQGVTAAD
                     VTPARLRVRWDASGGETVRMDIADDTGNPVGSVRALTLREIDPARLAALRTDRLPLYEI
                     RWNPVETPAGADATQDHVLVGADGHHLRDLPGVDPADYPDVESLRAAVADGRPAPSTVL
                     VSCVGPAPGAGVDPTVTGLPTRQVLDTVQGWLACGELAQSKLVVVTSGALPLPGDTDVD
                     LAMAPVAGLLRTARAENPGAVVHIDVDADSGPALPGALATGESEIALRNGVGLVPRLVV
                     RRSAEPAGPPRLDPDGTVLITGATGALGALVARHLVATYGVRHLLLLSRRGADAPGAGD
                     LLADLTAQGATARLVACDVGDRESVAAALATVPADHPLTAVVHAAGVIDDGVLPSLTPH
                     RLDVVWRPKVQAALHLHELTADADLAAFVLFSSVAGQLGNLGQGNYAAANVALDALAEH
                     RRAAGLAGTSLVWGLWGETDGTGAGAAAKLDRAALDRVSRGGLLPLSLDEGLALFDDAL
                     AAGPAVLVTARFDIAGLSARTETDNVPPRLSGLTRTARRPAGGQQASQPLVTRLAGLPV
                     GEQQKIVLDLVRRNVVAVLGGDRVARVDDDRSFKELGFESLSAVELRNRLSAATGLQLP
                     ATMVFDHPRPTSLADFIRETAAPADAEGPVLAELDRLSAAMAAASSDRGLRRLVAARLE
                     SMLADWKTTPADRSAGPEANARIESASVDEIFDLIDQEFGTVPQ"
     source          1..9182
                     /collection_date="2018-03-14"
                     /db_xref="taxon:2807623"
                     /geo_loc_name="South Korea: Sejong-si"
                     /isolation_source="riverside soil"
                     /mol_type="genomic DNA"
                     /organism="Micromonospora antibiotica"
                     /strain="MMS20-R2-23"
                     /submitter_seqid="contig46"
                     /type_material="type strain of Micromonospora antibiotica"
     region          1..9182
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /tool="antismash"
     cand_cluster    1..9182
                     /SMILES="C(C)C(=O)CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..9182
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[2969:>9182](+)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2970..>9182
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     aSDomain        157..648
                     /ASF="catalytic triad H,G,P inconclusive"
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32350_PKS_DH.1"
                     /evalue="1.50E-58"
                     /label="JQN83_RS32350_PKS_DH.1"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="215"
                     /protein_start="51"
                     /score="189.8"
                     /tool="antismash"
                     /translation="HPMLGAAVVLAGDAGTLFTGRVSLTTHPWLADHLVGGTVLLPGAA
                     FVDLALHCAAYAGLAMVDDLTLHAPLALPAHGVVDLQVVASAPDDTGRRRVTIHGRSAD
                     TDSGQDWTLHASGVLTPVADPAGTALTSWPPAGVVPVDLTGLYDRLAEHGYGYGTAFRG
                     L"
     aSModule        157..2673
                     /domains="nrpspksdomains_JQN83_RS32350_PKS_DH.1"
                     /domains="nrpspksdomains_JQN83_RS32350_PKS_KR.1"
                     /domains="nrpspksdomains_JQN83_RS32350_PKS_PP.1"
                     /incomplete
                     /locus_tags="JQN83_RS32350"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       241..315
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32350_0001"
                     /evalue="5.60E-10"
                     /label="PKSI-DH_m2"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="104"
                     /protein_start="79"
                     /score="31.7"
                     /tool="antismash"
                     /translation="WLADHLVGGTVLLPGAAFVDLALHC"
     aSDomain        1600..2139
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32350_PKS_KR.1"
                     /evalue="1.60E-57"
                     /label="JQN83_RS32350_PKS_KR.1"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="712"
                     /protein_start="532"
                     /score="186.4"
                     /specificity="KR activity: active"
                     /specificity="KR stereochemistry: (unknown)"
                     /tool="antismash"
                     /translation="GTVLITGATGALGALVARHLVATYGVRHLLLLSRRGADAPGAGDL
                     LADLTAQGATARLVACDVGDRESVAAALATVPADHPLTAVVHAAGVIDDGVLPSLTPHR
                     LDVVWRPKVQAALHLHELTADADLAAFVLFSSVAGQLGNLGQGNYAAANVALDALAEHR
                     RAAGLAGTSLVWGLWGE"
     CDS_motif       1603..1704
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32350_0002"
                     /evalue="1.70E-08"
                     /label="PKSI-KR_m1"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="567"
                     /protein_start="533"
                     /score="27.1"
                     /tool="antismash"
                     /translation="TVLITGATGALGALVARHLVATYGVRHLLLLSRR"
     CDS_motif       1984..2091
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32350_0003"
                     /evalue="1.20E-18"
                     /label="PKSI-KR_m4"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="696"
                     /protein_start="660"
                     /score="59.6"
                     /tool="antismash"
                     /translation="AAFVLFSSVAGQLGNLGQGNYAAANVALDALAEHRR"
     aSDomain        2422..2673
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32350_PKS_PP.1"
                     /evalue="1.40E-28"
                     /label="JQN83_RS32350_PKS_PP.1"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="890"
                     /protein_start="806"
                     /score="91.1"
                     /tool="antismash"
                     /translation="LAGLPVGEQQKIVLDLVRRNVVAVLGGDRVARVDDDRSFKELGFE
                     SLSAVELRNRLSAATGLQLPATMVFDHPRPTSLADFIRE"
     aSDomain        2701..2916
                     /aSDomain="PKS_Docking_Cterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32350_PKS_Docking_Cterm.
                     1"
                     /evalue="3.70E-22"
                     /label="JQN83_RS32350_PKS_Docking_Cterm.1"
                     /locus_tag="JQN83_RS32350"
                     /protein_end="971"
                     /protein_start="899"
                     /score="71.0"
                     /tool="antismash"
                     /translation="PVLAELDRLSAAMAAASSDRGLRRLVAARLESMLADWKTTPADRS
                     AGPEANARIESASVDEIFDLIDQEFGT"
     gene            2970..6092
                     /locus_tag="JQN83_RS32355"
                     /old_locus_tag="JQN83_32350"
     CDS             2970..6092
                     /NRPS_PKS="Domain: PKS_Docking_Nterm (4-31). E-value:
                     2.8e-11. Score: 34.8. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32355_PKS_Docking_Nterm.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (36-461). E-value:
                     3.1e-175. Score: 575.1. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32355_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (569-870). E-value: 3.4e-112.
                     Score: 366.6. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32355_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_PP (954-1036). E-value: 3.8e-22.
                     Score: 70.4. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32355_PKS_PP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788142.1"
                     /locus_tag="JQN83_RS32355"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_32350"
                     /product="type I polyketide synthase"
                     /protein_id="WP_208570953.1"
                     /sec_met_domain="mod_KS (E-value: 2.4e-220, bitscore:
                     719.3, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 4.5e-90, bitscore:
                     289.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.7e-113, bitscore:
                     366.6, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 8.4e-16, bitscore:
                     46.1, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGDEAKLLNYLKRMTIELRDAQERIRDLEESRHEPIALVGMSCQ
                     YPGGVQTPDELWDLVAGEVDAVAGFPTDRGWDLDGLYDPDPDTVGTSYAREGGFLYDAA
                     EFDAGLFAITPREALSIDPQQRLLLEHAWQSIERGGVDPRSLRGSDTGVFVGVMYNDYG
                     SRLMPAPEGFEGYVGNGSAASIASGRIAYSLGFEGPAITVDTACSSSLVAIHLACQSLR
                     WGECSLALAGGVTVMATPGVFIEFSRQRGLSPGGRCRSFSAGADGAGWAEGVGVVMLER
                     YSDALRNGHPVLGLIRGSAVNQDGASNGLTAPSGPAQERVIFNALADARLTPADLDAVE
                     GHGTGTTLGDPIEVRALQAVYGAGRDAQRPLWLGSLKSNIGHSQAAAGVGGLIKMVQAM
                     RNEVLPRTLHADPPTPHVDWSSGAVRLLREAVTWPVADRPRRVGISSFGISGTNAHLIL
                     EESPPPPAGEHGSAPVVTPDRPTAWPLSGNSPKALRDQARRLAAHLRRRPLRPVDVAYT
                     LNRRPLFAHRAVLLGTDPAELLTGLDRLAGGSGSAQVVRGRPAPPGGRTLAMIFSGQGS
                     QHVGMGRDLYPAFPAFAAALDAACAALDAHLPVALRDVLFAPAGTDLAALLDQTRFAQP
                     AIFAVEVALFRLLERFGIRPQRLVGHSVGEFAAAHVAGVLTLADAATLVTARGRLMQEL
                     PAGGAMVAVQATEAEVTPMLVDRAAEVAVAAVNGPSSVVVAGDEAAVAEIEAAWAAQGR
                     RTSRLRVSHAFHSPRMEPMLDEFRRVAASLTYRPPTVELVSTVTGRPVGPGELEDPQYW
                     VAHARRPVRFADAVRALAAAEVTEYLEVGPDSVLSAVVTENLGVAGTTGAVLPLLRRDV
                     DEPVAFLTGVANWYCRGGGVDWDALADGLAPTTVDLPTYAFQRKHYWLDAVAPMVATRR
                     APTPPDSLTDGSDEAEPSLAVTLLRLPAAERRATLLMALRGLAAEVMRLDRADDVAADV
                     PLLELGFTSLMAIDLRNRAAAATGVDLPAALVYEHPTFEAIVDYVDTLITV"
     aSDomain        2982..3062
                     /aSDomain="PKS_Docking_Nterm"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32355_PKS_Docking_Nterm.
                     1"
                     /evalue="2.80E-11"
                     /label="JQN83_RS32355_PKS_Docking_Nterm.1"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="31"
                     /protein_start="4"
                     /score="34.8"
                     /tool="antismash"
                     /translation="EAKLLNYLKRMTIELRDAQERIRDLEE"
     aSDomain        3078..4352
                     /ASF="found active site cysteine: True, scaffold matched
                     GSSS: True"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32355_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="3.10E-175"
                     /label="JQN83_RS32355_PKS_KS.1"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="461"
                     /protein_start="36"
                     /score="575.1"
                     /tool="antismash"
                     /translation="IALVGMSCQYPGGVQTPDELWDLVAGEVDAVAGFPTDRGWDLDGL
                     YDPDPDTVGTSYAREGGFLYDAAEFDAGLFAITPREALSIDPQQRLLLEHAWQSIERGG
                     VDPRSLRGSDTGVFVGVMYNDYGSRLMPAPEGFEGYVGNGSAASIASGRIAYSLGFEGP
                     AITVDTACSSSLVAIHLACQSLRWGECSLALAGGVTVMATPGVFIEFSRQRGLSPGGRC
                     RSFSAGADGAGWAEGVGVVMLERYSDALRNGHPVLGLIRGSAVNQDGASNGLTAPSGPA
                     QERVIFNALADARLTPADLDAVEGHGTGTTLGDPIEVRALQAVYGAGRDAQRPLWLGSL
                     KSNIGHSQAAAGVGGLIKMVQAMRNEVLPRTLHADPPTPHVDWSSGAVRLLREAVTWPV
                     ADRPRRVGISSFGISGTNAHLILEES"
     aSModule        3078..6077
                     /complete
                     /domains="nrpspksdomains_JQN83_RS32355_PKS_KS.1"
                     /domains="nrpspksdomains_JQN83_RS32355_PKS_AT.1"
                     /domains="nrpspksdomains_JQN83_RS32355_PKS_PP.1"
                     /locus_tags="JQN83_RS32355"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       3561..3608
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0001"
                     /evalue="4.90E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="213"
                     /protein_start="197"
                     /score="21.5"
                     /tool="antismash"
                     /translation="GPAITVDTACSSSLVA"
     CDS_motif       3984..4028
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0002"
                     /evalue="1.70E-03"
                     /label="PKSI-KS_m5"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="353"
                     /protein_start="338"
                     /score="10.9"
                     /tool="antismash"
                     /translation="VEGHGTGTTLGDPIE"
     CDS_motif       4089..4133
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0003"
                     /evalue="2.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="388"
                     /protein_start="373"
                     /score="10.8"
                     /tool="antismash"
                     /translation="GSLKSNIGHSQAAAG"
     aSDomain        4677..5579
                     /ASF="Malonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32355_PKS_AT.1"
                     /evalue="3.40E-112"
                     /label="JQN83_RS32355_PKS_AT.1"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="870"
                     /protein_start="569"
                     /score="366.6"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="IFSGQGSQHVGMGRDLYPAFPAFAAALDAACAALDAHLPVALRDV
                     LFAPAGTDLAALLDQTRFAQPAIFAVEVALFRLLERFGIRPQRLVGHSVGEFAAAHVAG
                     VLTLADAATLVTARGRLMQELPAGGAMVAVQATEAEVTPMLVDRAAEVAVAAVNGPSSV
                     VVAGDEAAVAEIEAAWAAQGRRTSRLRVSHAFHSPRMEPMLDEFRRVAASLTYRPPTVE
                     LVSTVTGRPVGPGELEDPQYWVAHARRPVRFADAVRALAAAEVTEYLEVGPDSVLSAVV
                     TENLGVAGTTGAVLPLLRRD"
     CDS_motif       4680..4727
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0004"
                     /evalue="3.70E-06"
                     /label="PKSI-AT-M_m1"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="586"
                     /protein_start="570"
                     /score="19.3"
                     /tool="antismash"
                     /translation="FSGQGSQHVGMGRDLY"
     CDS_motif       4854..4910
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0005"
                     /evalue="1.80E-03"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="647"
                     /protein_start="628"
                     /score="11.6"
                     /tool="antismash"
                     /translation="QTRFAQPAIFAVEVALFRL"
     CDS_motif       4923..5045
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0006"
                     /evalue="2.10E-22"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="692"
                     /protein_start="651"
                     /score="71.4"
                     /tool="antismash"
                     /translation="GIRPQRLVGHSVGEFAAAHVAGVLTLADAATLVTARGRLMQ"
     CDS_motif       5139..5177
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0007"
                     /evalue="7.40E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="736"
                     /protein_start="723"
                     /score="12.8"
                     /tool="antismash"
                     /translation="AAVNGPSSVVVAG"
     CDS_motif       5400..5435
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32355_0008"
                     /evalue="5.00E-04"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="822"
                     /protein_start="810"
                     /score="13.5"
                     /tool="antismash"
                     /translation="YWVAHARRPVRF"
     aSDomain        5832..6077
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32355_PKS_PP.1"
                     /evalue="3.80E-22"
                     /label="JQN83_RS32355_PKS_PP.1"
                     /locus_tag="JQN83_RS32355"
                     /protein_end="1036"
                     /protein_start="954"
                     /score="70.4"
                     /tool="antismash"
                     /translation="RLPAAERRATLLMALRGLAAEVMRLDRADDVAADVPLLELGFTSL
                     MAIDLRNRAAAATGVDLPAALVYEHPTFEAIVDYVDT"
     gene            6148..>9182
                     /locus_tag="JQN83_RS32360"
                     /old_locus_tag="JQN83_32355"
     CDS             6148..>9182
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (11-421). E-value:
                     1.5e-154. Score: 506.9. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32360_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (525-821). E-value: 1.1e-109.
                     Score: 358.4. Matches aSDomain:
                     nrpspksdomains_JQN83_RS32360_PKS_AT.1"
                     /NRPS_PKS="Domain: ACP (914-985). E-value: 5.5e-23. Score:
                     73.1. Matches aSDomain: nrpspksdomains_JQN83_RS32360_ACP.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021: malonyl CoA-acyl carrier protein transacylase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF012901.5"
                     /locus_tag="JQN83_RS32360"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_32355"
                     /product="type I polyketide synthase"
                     /protein_id="WP_208570954.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 9.3e-75, bitscore:
                     239.1, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 7.7e-156, bitscore:
                     506.9, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 5.4e-111, bitscore:
                     358.4, seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.6e-10, bitscore:
                     28.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPQTRDFSEDAIAVVGMSCRLPGAANPAAFWALLASGGNAIGAAP
                     ADRSGPTAPPGGFLDDVAGFDAAFFGISPREATAMDPQQRLMLELAWEAFEDARLAPDQ
                     LAGRPAAVYVGAIQDDYAQLAGRVPATVHTLTGLHRSVVANRISYTLGLTGPSVVVDSG
                     QSSALVAVHQACESLRAGTVSLALAGGVNLILEPGSTARVGEFGGLSPDGTAWVFDARA
                     NGYVRGEGGGLVVLKRLADAVADGDDISCVILGGAVNNDGGGAGLTVPDGDGQADVIRR
                     AHRQAGTDPAHVGYVELHGTGTPVGDPVEAGALGATIGVHRPADAPLAVGSAKTNVGHL
                     EGAAGLVGLLKLALSARHGQIPASLNFSTVNPRIDLVALNLQVQCALGPWPADAAGDGD
                     ALAGISSFGMGGTNAHLVVGRAPRPTGDRTDAPTPPHTAPWVVSAQNPAALRAQAATLH
                     RFLTTGGDVAGVDLGYSLATTRAALRHRAAIRAGDRADMLAALAALAAGDDRPDLVVGR
                     AQPGRVVFVFPGQGSQWEAMARGLYADSAVFRDRLDECADALAAYTDWDLRDVLLGGDV
                     DQLARVDVVQPVLFAVMVSLAALWRAHGVEPDAVVGHSQGEIAAACVAGALTLPDAARV
                     VALRSRAIRALAGTGAMASVAASAERLLPVLEQWSDQVAIGAINGPDSTVLSGAVDVLP
                     QVLAELTAQGLRCRAIPVDYASHSPQVETVRDEVLAQLTPITPTSAPVTFYSSVTGTPV
                     DTAGLDAAYWYRNLRQTVRFEPAATALLDDGYTTFIECSPHPVLAVGLRETFAAAGQPA
                     SVVPTLRRDEGGLDRFRQAVGHAYVVGVPVDWTTSFPGAQRISLPTYAFQRRPFWIDAP
                     ATDPGPTTVRPDVDAPVTEEPVGDGAWATDLRELPAERRLDVALELVRRRAAGILGHSN
                     ATDVDPETTFKELGFSSLTVVELRDRLVADTALPLPSSLAYDFPTPVLVAERLVGLVVG
                     LGSGVGVAGVGVGEAVAIVGMG"
     aSDomain        6181..7410
                     /ASF="found active site cysteine: False, scaffold matched
                     GSSS: False"
                     /ASF="found active site histidines: True"
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32360_PKS_KS.1"
                     /domain_subtypes="Hybrid-KS"
                     /evalue="1.50E-154"
                     /label="JQN83_RS32360_PKS_KS.1"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="421"
                     /protein_start="11"
                     /score="506.9"
                     /tool="antismash"
                     /translation="IAVVGMSCRLPGAANPAAFWALLASGGNAIGAAPADRSGPTAPPG
                     GFLDDVAGFDAAFFGISPREATAMDPQQRLMLELAWEAFEDARLAPDQLAGRPAAVYVG
                     AIQDDYAQLAGRVPATVHTLTGLHRSVVANRISYTLGLTGPSVVVDSGQSSALVAVHQA
                     CESLRAGTVSLALAGGVNLILEPGSTARVGEFGGLSPDGTAWVFDARANGYVRGEGGGL
                     VVLKRLADAVADGDDISCVILGGAVNNDGGGAGLTVPDGDGQADVIRRAHRQAGTDPAH
                     VGYVELHGTGTPVGDPVEAGALGATIGVHRPADAPLAVGSAKTNVGHLEGAAGLVGLLK
                     LALSARHGQIPASLNFSTVNPRIDLVALNLQVQCALGPWPADAAGDGDALAGISSFGMG
                     GTNAHLVVGRA"
     aSModule        6181..9102
                     /complete
                     /domains="nrpspksdomains_JQN83_RS32360_PKS_KS.1"
                     /domains="nrpspksdomains_JQN83_RS32360_PKS_AT.1"
                     /domains="nrpspksdomains_JQN83_RS32360_ACP.1"
                     /locus_tags="JQN83_RS32360"
                     /monomer_pairings="mmal -> Me-mal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       6799..6837
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0001"
                     /evalue="3.00E-05"
                     /label="PKSI-KS_m4"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="230"
                     /protein_start="217"
                     /score="16.8"
                     /tool="antismash"
                     /translation="FDARANGYVRGEG"
     CDS_motif       7030..7077
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0002"
                     /evalue="2.30E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="310"
                     /protein_start="294"
                     /score="13.2"
                     /tool="antismash"
                     /translation="YVELHGTGTPVGDPVE"
     CDS_motif       7138..7182
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0003"
                     /evalue="2.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="345"
                     /protein_start="330"
                     /score="10.8"
                     /tool="antismash"
                     /translation="GSAKTNVGHLEGAAG"
     CDS_motif       7717..7773
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0004"
                     /evalue="4.40E-09"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="542"
                     /protein_start="523"
                     /score="28.0"
                     /tool="antismash"
                     /translation="VFVFPGQGSQWEAMARGLY"
     aSDomain        7723..8610
                     /ASF="Methylmalonyl-CoA specific"
                     /ASF="found active site serine: True, scaffold matched
                     GHGE: True"
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32360_PKS_AT.1"
                     /evalue="1.10E-109"
                     /label="JQN83_RS32360_PKS_AT.1"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="821"
                     /protein_start="525"
                     /score="358.4"
                     /specificity="substrate consensus: mmal"
                     /specificity="PKS signature: Methylmalonyl-CoA"
                     /specificity="Minowa: mmal"
                     /tool="antismash"
                     /translation="VFPGQGSQWEAMARGLYADSAVFRDRLDECADALAAYTDWDLRDV
                     LLGGDVDQLARVDVVQPVLFAVMVSLAALWRAHGVEPDAVVGHSQGEIAAACVAGALTL
                     PDAARVVALRSRAIRALAGTGAMASVAASAERLLPVLEQWSDQVAIGAINGPDSTVLSG
                     AVDVLPQVLAELTAQGLRCRAIPVDYASHSPQVETVRDEVLAQLTPITPTSAPVTFYSS
                     VTGTPVDTAGLDAAYWYRNLRQTVRFEPAATALLDDGYTTFIECSPHPVLAVGLRETFA
                     AAGQPASVVPTLRRD"
     CDS_motif       7885..7953
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0005"
                     /evalue="9.10E-12"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="602"
                     /protein_start="579"
                     /score="36.7"
                     /tool="antismash"
                     /translation="ARVDVVQPVLFAVMVSLAALWRA"
     CDS_motif       7957..8067
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0006"
                     /evalue="4.10E-20"
                     /label="PKSI-AT-mM_m3"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="640"
                     /protein_start="603"
                     /score="63.5"
                     /tool="antismash"
                     /translation="GVEPDAVVGHSQGEIAAACVAGALTLPDAARVVALRS"
     CDS_motif       8176..8211
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0007"
                     /evalue="8.90E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="688"
                     /protein_start="676"
                     /score="12.6"
                     /tool="antismash"
                     /translation="AINGPDSTVLSG"
     CDS_motif       8281..8313
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0008"
                     /evalue="1.20E-04"
                     /label="PKSI-AT-mM_m6"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="722"
                     /protein_start="711"
                     /score="14.6"
                     /tool="antismash"
                     /translation="VDYASHSPQVE"
     CDS_motif       8419..8466
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0009"
                     /evalue="2.20E-06"
                     /label="PKSI-AT-mM_m8"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="773"
                     /protein_start="757"
                     /score="19.4"
                     /tool="antismash"
                     /translation="LDAAYWYRNLRQTVRF"
     CDS_motif       8509..8538
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JQN83_RS32360_0010"
                     /evalue="2.00E-03"
                     /label="PKSI-AT-mM_m9"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="797"
                     /protein_start="787"
                     /score="10.7"
                     /tool="antismash"
                     /translation="FIECSPHPVL"
     aSDomain        8890..9102
                     /ASF="found active site serine: True"
                     /ASF="non-beta-branching ACP"
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JQN83_RS32360_ACP.1"
                     /evalue="5.50E-23"
                     /label="JQN83_RS32360_ACP.1"
                     /locus_tag="JQN83_RS32360"
                     /protein_end="985"
                     /protein_start="914"
                     /score="73.1"
                     /tool="antismash"
                     /translation="LELVRRRAAGILGHSNATDVDPETTFKELGFSSLTVVELRDRLVA
                     DTALPLPSSLAYDFPTPVLVAERLVG"
ORIGIN
        1 tttgttgcgg gggtggaggt tgattggcgt cgggtggtgg gtgcgggtcg gttggtggat
       61 gtgccgacgt atgcgttcca gggggagcgg tactggttgg aggcaccccg caacaccggc
      121 gacctgagcg ccgccggtct ggaccaggcc ggccacccga tgctcggcgc cgcggtcgtg
      181 ctcgccggtg acgccgggac cctcttcacc ggccgggtct cgctcaccac ccacccgtgg
      241 ctcgccgacc acctggtcgg cggcaccgtc ctcctgcccg gcgcggcctt cgtcgacctg
      301 gccctgcact gcgccgcgta cgccggactg gccatggtcg acgacctgac cctgcacgcg
      361 ccgctcgcgc tgcccgcgca cggcgtcgtg gacctccagg tcgtcgcgtc cgccccggac
      421 gacaccggcc gccgccgggt gacgatccac ggccggtcgg ccgacaccga ctccggtcag
      481 gactggaccc tgcacgccag cggtgtcctg accccggttg ccgacccggc cggcacggcg
      541 ctgaccagtt ggccgcccgc cggcgtggtg cccgtcgacc tcaccggcct gtacgaccgg
      601 ctcgccgagc acggctacgg ctacggcacc gccttccggg gcctgaccgg gctgtggcgg
      661 gacccggacc actgctacgc cgagatcacc ttgccggagg ggaccgaccc caccggccac
      721 cggctgcacc cggcgctgct cgacgcggcc ctgcaccccc tgctggcgct cgcgctcgcc
      781 gacaacgacg gcccgctgcc gctgcggatc ccgttctcct ggcagggggt gacggccgcc
      841 gacgtgacgc ccgcccgact gcgggtgcgg tgggacgcct ccggcggcga aaccgtccgg
      901 atggacatcg ccgacgacac cggcaacccg gtcggatcgg tacgcgcgct gaccctccgc
      961 gagatcgacc cggcccggct cgccgcgctg cgtaccgacc ggctgccgct ctacgagatc
     1021 cgctggaacc ccgtcgagac cccggccggg gcggacgcca cccaggacca tgtcctcgtc
     1081 ggtgcggacg gccaccacct gcgtgacctg ccgggcgtcg atccggcgga ctacccggac
     1141 gtcgagtcgc tgcgggcggc ggtcgccgac ggccgaccgg caccgtccac cgtgctggtc
     1201 tcctgcgtgg gcccggcacc cggtgccggg gtcgacccga ccgtcaccgg gctacccacc
     1261 cggcaggtgc tcgacacggt gcagggctgg ctcgcctgcg gtgaactggc gcagtcgaag
     1321 ctggtcgtgg tgaccagcgg ggcgttgccg ctgcccggtg acaccgacgt cgacctggcc
     1381 atggcaccgg tcgccggcct gctgcgtacc gcgcgggcgg agaaccccgg cgcggtggtg
     1441 cacatcgacg tcgacgccga ttcgggcccg gccctgcccg gcgcgttggc caccggggag
     1501 tcggagatcg cgctgcgaaa cggcgtcggc ctcgtacccc ggttggtggt acgccggtcg
     1561 gcggagcctg ccgggccgcc gaggctcgac ccggacggca cggtcctgat caccggggcc
     1621 accggggcgc tcggcgctct cgtcgcccgg cacctggtgg cgacctacgg cgtgcggcac
     1681 ctgctgttgc tgagccggcg cggcgcggac gcccccggtg ccggtgacct gctcgccgac
     1741 ctcaccgcgc agggggcgac ggcccggctg gtcgcctgcg acgtcgggga ccgcgaatcc
     1801 gtcgccgcgg cgctcgccac ggtgccggcc gaccacccgc tcaccgcggt cgtgcacgcc
     1861 gccggggtca tcgacgacgg ggtgctgccc agcctcaccc cgcaccgcct cgacgtcgtc
     1921 tggcggccga aggtgcaggc agccctgcac ctgcacgagc tgaccgcgga cgccgacctg
     1981 gccgcgttcg tgctgttctc ctcggtggcg ggtcaactcg gcaacctcgg tcagggcaac
     2041 tacgcggcgg ccaacgtcgc cctcgacgcg ctcgccgaac accgccgggc cgccggcctg
     2101 gccggcacct ccctggtctg ggggttgtgg ggcgagaccg acggcaccgg ggccggcgcg
     2161 gcggcgaaac tcgaccgggc ggcgctggac cgggtcagcc ggggcggtct gctgccgctg
     2221 tcgctcgacg aggggctggc cctcttcgac gacgcgctgg ccgccggccc ggcggtgctg
     2281 gtcaccgccc gcttcgacat cgccggcctc agcgcccgca ccgagaccga caacgtgcca
     2341 ccccggctgt ccgggctgac ccgtacggcc cgccgccccg ccggtggcca acaggcgtcc
     2401 caaccgctgg tcacccggct cgccgggctg ccggtcggcg aacaacagaa gatcgtgctg
     2461 gacctggtac gcaggaacgt cgtcgccgtc ctcggcggcg accgggtggc gcgcgtcgac
     2521 gacgaccggt ccttcaagga actcggcttc gagtcgctgt ccgcggtcga gttgcgcaac
     2581 cggctcagcg ccgccaccgg tctgcaactg cccgccacga tggtcttcga ccatccacgg
     2641 cccacctcgc tggccgactt catccgggag accgccgcgc cggccgacgc cgagggcccg
     2701 gtcctcgccg aactcgaccg gctgtccgcc gccatggcgg cggcctcctc cgaccggggg
     2761 ctgcgccggc tggtcgccgc ccggctggag agcatgctcg ccgactggaa gacgaccccg
     2821 gcggaccggt cggccggccc ggaagccaac gcgcgcatcg agtccgcgtc cgtggacgag
     2881 atcttcgacc tgatcgacca ggagttcggc acggtgccgc agtgagcggc caccggccgc
     2941 aggagtcaac gagagcgggt gtccagcgca tgtcaggtga cgaggcgaag ctcctcaact
     3001 acctcaagcg gatgaccatt gagctgcgcg acgcccagga acgcatccgg gatctcgaag
     3061 agagccgcca cgagccgatc gcgctcgtcg ggatgagctg ccagtacccc ggcggggtgc
     3121 agaccccgga cgagttgtgg gacctggtcg ccggtgaggt cgacgccgtg gccgggttcc
     3181 ccaccgaccg ggggtgggac ctcgacgggc tctacgaccc ggacccggac accgtcggca
     3241 ccagctacgc ccgcgagggt ggtttcctct acgacgcggc cgagttcgac gccgggctgt
     3301 tcgccatcac cccccgcgag gcgctgtcca tcgaccccca gcagcgccta ctgctcgaac
     3361 acgcctggca gtcgatcgag cggggcggcg tcgacccccg gtcgctgcgt ggtagcgaca
     3421 ccggcgtgtt cgtcggggtg atgtacaacg actacgggtc gcggctgatg ccggcaccgg
     3481 agggcttcga ggggtacgtc ggcaacggca gcgcggcgag catcgcctcc ggccggatcg
     3541 cctactcgtt gggcttcgag gggccggcga tcaccgtcga caccgcctgc tcgtcgtcgc
     3601 tggtggcgat ccacctggcc tgccagtcgc tgcgctgggg cgagtgttcc ctggccctgg
     3661 ccggaggcgt cacggtgatg gcgacaccgg gggtgttcat cgagttctcc cggcagcgcg
     3721 gcctgtcgcc cggcggccgg tgccggtcct tctccgccgg ggccgacggc gccggctggg
     3781 ccgagggcgt cggagtggtc atgttggagc ggtactccga cgcgctgcgc aacgggcacc
     3841 cggtgctcgg tctgatccgg ggcagcgcgg tcaaccagga cggcgccagc aacggcctca
     3901 ccgccccgag cgggcctgcc caggaacgtg tcatcttcaa cgccctcgcc gacgcccggc
     3961 tcacccccgc cgacctcgac gcggtggagg ggcacggcac cggcaccacc ctcggcgacc
     4021 cgatcgaggt acgcgccctg caagccgtgt acggcgccgg ccgggacgcg caacgccccc
     4081 tctggctggg ctcgctcaag tccaacatcg ggcacagcca ggccgctgcc ggagtcggcg
     4141 gcctgatcaa gatggtgcag gcgatgcgga acgaggtgct gccccggacc ctgcacgccg
     4201 acccaccgac cccccacgtg gactggtcct cgggcgcggt acgcctgctg cgtgaggccg
     4261 tgacctggcc ggtcgccgat cggccacgtc gcgtcggcat ctcctccttc gggatcagcg
     4321 gcacgaacgc ccacctgatc ctggaggagt cgccaccccc gcccgccggg gaacacgggt
     4381 ccgcgccggt ggtgacaccc gaccgcccga ccgcctggcc actgtcggga aactcgccca
     4441 aggcactgcg ggaccaggca cgacggctcg ccgcccacct gcggcgtcga ccgctgcggc
     4501 cggtcgacgt ggcgtacacc ctgaatcgtc gtccgctgtt cgcccaccgt gccgttctgc
     4561 tcgggaccga cccggccgag ctgctcaccg gtctggaccg gttggccggc ggctcaggct
     4621 ccgcccaggt ggtgcggggc cgccccgccc cgcccggcgg tcgtaccctc gccatgatct
     4681 tctcgggcca gggttcgcag cacgtgggca tgggccgcga cctctacccg gcgttcccgg
     4741 ccttcgccgc ggccctcgac gcggcgtgcg cggccctcga cgcgcacctg ccggtggcgc
     4801 tgcgcgacgt gctcttcgcc ccggcgggca ccgacctcgc cgcactgctc gaccagaccc
     4861 ggttcgccca acctgccatc ttcgccgtgg aggtggcgct gttccggctc ctcgaacggt
     4921 tcggcatccg gccccaacgg ctcgtcgggc actcggtcgg cgagttcgcc gccgcccacg
     4981 tcgccggagt gctcacgctg gccgacgcgg ccaccctggt caccgcacgc ggacgactca
     5041 tgcaggaact gccggccggc ggcgcgatgg tggcggtgca ggccaccgag gccgaggtta
     5101 caccgatgct ggtggaccgg gccgccgagg tcgccgtcgc cgccgtgaac ggaccgtcct
     5161 ccgtcgtggt cgccggtgac gaggcggcgg tcgccgagat cgaggcggcc tgggccgccc
     5221 agggccggcg gaccagccga ctgcgggtca gccacgcctt ccactccccc cggatggagc
     5281 ccatgctcga cgagttccgg cgggtggcgg cgagcctgac ctaccggccg ccgaccgtcg
     5341 agctggtgtc caccgtgacc ggtcgaccgg tcggcccggg tgaactggag gacccgcaat
     5401 actgggtggc gcacgcccgc cggccggtcc gcttcgccga cgccgtccgg gcgctggccg
     5461 ccgccgaggt caccgagtac ctcgaagtcg gcccggacag tgtgctgagc gcggtggtca
     5521 ccgagaacct cggtgtcgcc ggcacgaccg gtgcggtgct gccgttgctg cgccgcgacg
     5581 tcgacgagcc ggtggcgttc ctgaccgggg tcgcgaactg gtactgccgg ggtggcggcg
     5641 tcgactggga cgcgctggcc gacgggctgg ccccgaccac cgtcgacctg cccacctacg
     5701 cgttccagcg caagcactac tggctggacg cggtcgcacc gatggtggcc acccgccggg
     5761 cacccacgcc gcccgactcg ctcaccgacg gcagtgacga ggcggagccg tcgctggccg
     5821 tcaccctgct gcggctaccg gccgccgaac gccgggcgac cctgctgatg gccctgcgcg
     5881 ggctggccgc cgaggtgatg cggctcgacc gggccgacga cgtcgccgcc gacgtccccc
     5941 tgctcgaact cgggttcacc tcgctgatgg cgatcgacct gcgcaaccgg gccgccgccg
     6001 ccaccggagt ggacctgccc gccgcgctgg tctacgagca cccgacgttc gaggcgatcg
     6061 tcgactacgt cgacaccctg atcaccgtct aagaccctcc gcccaccccc gatggcccgc
     6121 gatcgacgca gaatgaggtc agttgtcatg ccgcagaccc gtgacttttc cgaggacgcg
     6181 atcgctgtcg tcggcatgtc ctgccgcctg cccggcgcgg cgaacccggc cgcgttctgg
     6241 gccctgctcg ccagcggggg caacgcgatc ggcgcggcac ccgccgaccg gtcggggccg
     6301 accgcgcccc ccggcggctt cctcgacgac gtcgccgggt tcgacgccgc cttcttcggc
     6361 atctccccgc gcgaggccac cgcgatggac ccgcagcagc ggctgatgct ggagctggcg
     6421 tgggaggcgt tcgaggacgc ccggctggca cccgaccagc tggccgggcg gcccgcggcg
     6481 gtctacgtcg gcgccatcca ggacgactac gcccaactgg ccggccgggt gcccgccacc
     6541 gtccacaccc tcaccgggct gcaccgcagc gtcgtggcca accggatctc ctacacgctc
     6601 ggcctgaccg ggcccagcgt ggtcgtcgac tccgggcagt cgtcggcgct ggtcgccgtg
     6661 caccaggcct gcgagagcct gcgcgccggg accgtctcgc tggccctggc cggcggcgtg
     6721 aacctcatcc tggaaccggg gagcaccgcc cgggtcggcg agttcggcgg tctctccccg
     6781 gacggcaccg cctgggtctt cgacgcgcgc gccaacggct acgtacgcgg tgagggcggc
     6841 ggcctggtcg tgctcaagcg gctcgccgac gcggtggccg acggcgacga catctcctgc
     6901 gtgatcctcg gcggggccgt caacaacgac ggtggcggcg ccggcctgac cgtcccggac
     6961 ggcgacgggc aggccgacgt gatccggcgg gcgcaccggc aggcgggcac cgacccggcc
     7021 cacgtcggat acgtcgagct gcacggcacg ggcacgcccg tcggcgaccc ggtcgaggcc
     7081 ggcgcgctgg gtgcgacgat cggcgtgcac cggccggcgg acgctccgct ggccgtcggt
     7141 tcggccaaga ccaacgtcgg gcacctcgaa ggggccgccg gtctggtcgg cctgctcaag
     7201 ctcgcgttga gcgcccggca cgggcagatc ccggcgagtc tgaacttcag caccgtcaac
     7261 ccgcgcatcg acctggtcgc gctgaacctg caggtgcagt gcgcgctcgg gccgtggccg
     7321 gcggacgccg ccggtgacgg cgacgccctg gccggcatct cgtcgttcgg aatgggcggc
     7381 accaacgccc acctcgtcgt cgggcgggcg ccccggccca ccggcgaccg gaccgacgcg
     7441 ccgacgcccc cgcacaccgc tccctgggtg gtgtccgctc agaaccccgc cgcactgcgc
     7501 gcccaggcgg ccacgctgca ccggttcctc accaccggtg gcgacgtcgc gggcgtcgac
     7561 ctcggctact cgctcgcgac gacccgggcc gcgctgcggc accgggcggc gatccgcgcc
     7621 ggtgaccgcg ccgacatgct cgccgccctc gccgcgctcg ccgccggtga cgaccgaccc
     7681 gacctggtcg tcggccgcgc ccagcccggc cgggtggtct tcgtcttccc cggccagggc
     7741 tcgcagtggg aggcgatggc ccgtggcctg tacgccgact ccgcggtgtt ccgcgaccgc
     7801 ctcgacgaat gtgccgacgc gctggccgcg tacaccgact gggacctgcg cgacgtcctg
     7861 ctcggcgggg acgtcgacca gttggcgcgg gtcgacgttg tccagccggt gctgttcgcc
     7921 gtgatggtgt cgctggcggc actgtggcgg gcgcacgggg tggaacccga cgcggtggtg
     7981 gggcactccc agggtgagat cgccgccgcg tgcgtggccg gcgcgctgac cctgccggac
     8041 gcggcccggg tggtggccct gcgcagtcgg gcgatccggg ccctggccgg cacgggcgcg
     8101 atggcgtcgg tggcggcctc ggccgagcgg ctgctgccgg tgctggagca gtggagcgac
     8161 caggttgcga tcggggcgat caacggcccc gactcgaccg tcctgtccgg agcggtggac
     8221 gtgctgccgc aggtgctcgc cgagctgacc gcgcaggggt tgcggtgccg ggccatcccg
     8281 gtggactacg cctcccactc cccgcaggtc gagacggtcc gcgacgaggt gctcgcccag
     8341 ctcaccccga tcacgcccac cagtgccccg gtcaccttct actcgtcggt gaccggcacg
     8401 cccgtcgaca cggccggtct ggacgccgcc tactggtacc gcaacctacg gcagaccgtc
     8461 cggttcgagc cggccgccac ggcgttgctc gacgacgggt acaccacgtt catcgagtgc
     8521 agcccgcacc cggtgctggc cgtcggcctg cgggagacct tcgccgcagc cgggcagccg
     8581 gcgtccgtcg tgcccaccct gcggcgcgac gagggcggcc tcgaccgctt ccggcaggcc
     8641 gtcggccacg cgtacgtcgt gggtgtcccg gtcgactgga ccacgtcctt cccgggcgca
     8701 cagcggatct ccctgcccac ctacgcgttc cagcgcaggc ccttctggat cgacgcgccc
     8761 gcaacggacc cgggcccgac gaccgtacgg cccgacgtcg acgcgccggt gaccgaggag
     8821 cccgtcggcg acggggcctg ggcgaccgac ctgcgggagc tgccggcgga gcgtcgcctc
     8881 gacgtcgccc tggagctggt ccggcggcgg gccgccggca tcctcggtca ttcgaacgcc
     8941 accgacgtgg acccggagac gacgttcaag gaactcggct tctcctcgct caccgtcgtg
     9001 gaactacgcg accggctggt cgccgacacc gccctgccgc tgccgtcctc gctcgcctac
     9061 gactttccga ctccggtgtt ggtggcggag cggttggtgg gtttggtggt gggtttgggt
     9121 tcgggtgtgg gtgttgcggg tgtgggtgtg ggtgaggcgg tggcgattgt ggggatgggg
     9181 tg
//
