LOCUS       NZ_JAGFWR010000040     11063 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Micromonospora antibiotica strain MMS20-R2-23 contig40, whole genome
            shotgun sequence.
ACCESSION   NZ_JAGFWR010000040
VERSION     NZ_JAGFWR010000040.1
KEYWORDS    WGS; RefSeq.
SOURCE      Micromonospora antibiotica
  ORGANISM  Micromonospora antibiotica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 29488)
  AUTHORS   Lee,D.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2021) Microbiology & Molecular Biology, Chungnam
            National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, South
            Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 79.63x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017599305.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 02:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,561
            CDSs (total)                      :: 6,498
            Genes (coding)                    :: 6,378
            CDSs (with protein)               :: 6,378
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 20 of 120
            Pseudo Genes (incomplete)         :: 107 of 120
            Pseudo Genes (internal stop)      :: 2 of 120
            Pseudo Genes (multiple problems)  :: 9 of 120
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:14:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 18425
            Orig. end                         :: 29488
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAGFWR010000040.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11063
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phenazine"
                     /region_number="1"
                     /rules="phzB"
                     /tool="antismash"
     cand_cluster    1..11063
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="phzB"
                     /kind="single"
                     /product="phenazine"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11063
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[10000:10489](+)"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10489
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="phzB"
                     /neighbourhood="10000"
                     /product="phenazine"
                     /protocluster_number="1"
     misc_feature    67..82
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.2"
                     /tool="antismash"
     gene            413..766
                     /locus_tag="JQN83_RS31885"
                     /old_locus_tag="JQN83_31880"
     CDS             413..766
                     /EC_number="3.5.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020522599.1"
                     /locus_tag="JQN83_RS31885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31880"
                     /product="RidA family protein"
                     /protein_id="WP_208570873.1"
                     /transl_table=11
                     /translation="MGFNQGEVVSGQTRTLYVSGQTSMSPEGKPEHDGDIAAQLALCVD
                     NLEAVLKEAGMTLANLIRLNVYTTDVDQLFPHYGVLAGRLGSAGVAPTTTMLGVTRLAI
                     PGQLVELEGTAVA"
     gene            829..2076
                     /locus_tag="JQN83_RS31890"
                     /old_locus_tag="JQN83_31885"
     CDS             829..2076
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF033540.1"
                     /locus_tag="JQN83_RS31890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31885"
                     /product="IS701 family transposase"
                     /protein_id="WP_208570863.1"
                     /transl_table=11
                     /translation="MTLVAKSLPPGWASRLRQLTDRVGHVFARPEPRVVFHDLVEGLLS
                     DLPKKNCWSLSERAGHSHPGRMQALLSRGAWSADALEAEVRSYVIEHLGDPDAMLVIRD
                     AQVIKRGDKSVGVGPQHCTLTNRIENCQVAVMLAYAAPAGTAYVGHRLHLPRTWIADSV
                     RRTKAGIPADVAYASRPEQAVELLAEAVDAAVPFSWVSLDDGYAQHPQVRDWCVQRALP
                     YIAAVPATLPLIRVGATRSSTTTGPEQILGHIADSYWHRRTERATGRTHDWALVGLGGS
                     LLVGGEVPTRGFAQSLMVRRSVDNPHDVAYFVAHARRRTPASVLIGAAERRHRAGQPEQ
                     PGDELIGLDQYQVRTWTAWHHTITTCMLAHAFRTVQRATAPDARTAVRRPRQVAACRPG
                     VGTGAASHPLRSGSGH"
     misc_feature    complement(2560..2574)
                     /note="TFBS match to ZuR_variant_1, Zinc-responsive
                     repressor, confidence: weak, score: 17.34"
                     /tool="antismash"
     gene            2625..3263
                     /locus_tag="JQN83_RS31895"
                     /old_locus_tag="JQN83_31890"
     CDS             2625..3263
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQN83_RS31895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQN83_31890"
                     /product="nuclear transport factor 2 family protein"
                     /protein_id="WP_208570864.1"
                     /transl_table=11
                     /translation="MHEIKRTIPIVAAGGILLAAGTLFGANSAYGQTDTNNPQQTHANH
                     SVDHRAHARVPGFVAPTTTAVPTPATNTAALQAGAQSPAELINLLGQRIVAKDVDGIVA
                     LQEREAAIIDWDGSVIRGHAAIRAFYVEWFESDPILQVSPLQIVEAGGTRVGNKVIGRS
                     ASVMGTYTLEQDGPDGTRVSFSGNFCDIVRQQLNGTWLYIQDNPYPPHS"
     misc_feature    3408..3423
                     /note="TFBS match to CRP, Cyclic AMP receptor protein,
                     confidence: medium, score: 16.24"
                     /tool="antismash"
     gene            3409..4611
                     /locus_tag="JQN83_RS31900"
                     /old_locus_tag="JQN83_31895"
     CDS             3409..4611
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018812033.1"
                     /locus_tag="JQN83_RS31900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31895"
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_307800000.1"
                     /transl_table=11
                     /translation="MNTISLDVPPVEAAEQQPEWEDPAQVAQIRDVLASLPPLIEAESL
                     PTFQSSLADVAAGHAQVLQAGDCAEDPAECTAEHVRRKVDLLDALAATMSAATGRPVVR
                     VGRIAGQYAKPRSRPTEQVDGVDLPVYRGHLVNDPAATRPARRPDPQRLLAGYRSARRT
                     LSELGTVRAAGAPVWTSHEALLLDYEVPMLRRDRAGRVALTSTHWPWIGERTRQLDGAH
                     VALLAQVVNPVACKVGPTMTVVDLLALCARLDPLREPGRLTLIARLGADVVADRLPPLV
                     RAVRAAGHPVVWLVDPLHGNTVTAATGRKTRILSTILREVTAFQIAVHAEGGVAGGVHL
                     ETTPDDVTECLDDGHSSEPARLRYTSLCDPRLNPRQAQTVVSAWRASPLTNRAEEKPCR
                     A"
     gene            4599..5222
                     /locus_tag="JQN83_RS31905"
                     /old_locus_tag="JQN83_31900"
     CDS             4599..5222
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013053.5"
                     /locus_tag="JQN83_RS31905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31900"
                     /product="isochorismatase family protein"
                     /protein_id="WP_208570866.1"
                     /transl_table=11
                     /translation="MPGLTPIAAYPLPTTGELPVSIAQWTPDASRAALLVHDMQRYFLG
                     PFDPSVREALVRNCVRLRQRCGELRVPTYYTAQPGGMTEQERGLLKDIWGPGMSGQPGD
                     REIVTELAPGPADHVLTKWRYSAFHRSDLLTRLRRQGRDQLIVCGVYGHVGVLATALDA
                     FTNDIQPFLVADAIGDFSADHHQLTLDYAATRCAVVTTTEEVFP"
     misc_feature    4782..4784
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            5219..7135
                     /locus_tag="JQN83_RS31910"
                     /old_locus_tag="JQN83_31905"
     CDS             5219..7135
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1018: isochorismate synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018251454.1"
                     /locus_tag="JQN83_RS31910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31905"
                     /product="anthranilate synthase family protein"
                     /protein_id="WP_208570867.1"
                     /transl_table=11
                     /translation="MNAARLLRQLVDPGREAFALLHRPESVGGDRVEILSGRISTVARL
                     ADVPLPDAPLHEAGPDDEALHETLVLVPHQQITERGFTAVMDGSPLITLSVTEQGSMTR
                     AEAFEHLPDDPISLTNGGFDTDDGSYADTVRAVLANEISTGAGANFVIKRSYVTTVTGY
                     SPRTALSLFRRLLARETGAYWTFLVHTGTRTFVGATPERHVSLRGGVAAMTPISGTYRY
                     PRTGPVLAEVLDFLTDGKETDELYMVLDEELKMMARVCDGGGRVVGPFLRQMAWLAHTE
                     YNIEGPSSLDPRDILRETMFAPTVTGSPLENAFRVIARYEPHGRGYYGGIAALIGRDAG
                     GARTMDAAIMIRTADIRPSQTDDSARVEVGVGATLVRHSDPDAEVAETHAKAAGVLSAL
                     GIGERLDGHPLIRQALDRRNTAIASFWLSDAQTRRRPQPALAGRRALIVDAEDAFSAML
                     AHQLRALGLAVQVARADTRPGFDAHDLVVLGPGPGDPRDAADPRMSHLTEAIDQLLARR
                     TPFLAVCLSHQLLCRHLGLPLRRRDIPNQGVQREIDLFGTPARVGFYNSFVAYARMEQF
                     HSPRAGEVRVSHDPTTGEVHALRGAHFSSVQFHPESVLTQDGERVLGDLLASLTHIEEV
                     MNA"
     gene            7132..7479
                     /locus_tag="JQN83_RS31915"
                     /old_locus_tag="JQN83_31910"
     CDS             7132..7479
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) thio_amide"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQN83_RS31915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQN83_31910"
                     /product="hypothetical protein"
                     /protein_id="WP_208570868.1"
                     /sec_met_domain="thio_amide (E-value: 9.2e-20, bitscore:
                     61.2, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKAAVSWWDLAESTQTIDSLRHYLREEGVQPWERVHGMRLKFWIS
                     DRETNRWGAVMLWDATADLTAPLPPNRATELIGYPPTVRMMTEVEAIVEGLHAGPSDDR
                     GLAFGPVRNPS"
     gene            7476..8093
                     /gene="phzG"
                     /locus_tag="JQN83_RS31920"
                     /old_locus_tag="JQN83_31915"
     CDS             7476..8093
                     /EC_number="1.10.3.16"
                     /GO_function="GO:0016682 - oxidoreductase activity, acting
                     on diphenols and related substances as donors, oxygen as
                     acceptor [Evidence IEA]"
                     /codon_start=1
                     /gene="phzG"
                     /inference="COORDINATES: protein motif:HMM:NF038138.1"
                     /locus_tag="JQN83_RS31920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31915"
                     /product="phenazine biosynthesis FMN-dependent oxidase
                     PhzG"
                     /protein_id="WP_208570869.1"
                     /transl_table=11
                     /translation="MSTSAQQLGVDVFATPPDEPMGLLRSWLDAARADAVREPGALALA
                     TADADGRPSTRMVQVLAVRDNGLLFATHSGSRKGRELAANRWASGVLYWREVARQVVVG
                     GPTGPLGADEADALWTARPVATHPMSVASQQSAPLTDEDALREQARRLGDRGMPLPRPD
                     AWLAYLLEPDSVEFWESDPGRLHRRLRFDRDGTGWRSGRLQP"
     gene            8133..9968
                     /gene="asnB"
                     /locus_tag="JQN83_RS31925"
                     /old_locus_tag="JQN83_31920"
     CDS             8133..9968
                     /EC_number="6.3.5.4"
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="asnB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018222377.1"
                     /locus_tag="JQN83_RS31925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31920"
                     /product="asparagine synthase (glutamine-hydrolyzing)"
                     /protein_id="WP_208570870.1"
                     /sec_met_domain="GATase_7 (E-value: 1.3e-48, bitscore:
                     154.6, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 1.1e-87, bitscore:
                     285.5, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MCGIAGWVSYDRDLTRHQADLDAMTATMACRGPDASGVQLDRHAG
                     LGHRRLAVIDVDGGTQPMAVQTDDGTVTITYSGEAYNFGELRGELRRRGHRFRTRSDTE
                     VVLHGYLEWGEAVAERLNGMYAFAVWDSRVDKLVLIRDRLGVKPLYYYRTDDGVLFGSE
                     PKAILANPLAERAVDLAGIRELVSFTQTPGSAVWCGMNEVLPGGVVTVDRAGLREHRYW
                     TLPSRPHTDDLPTTIANVRSLLRDVVERQLVSDVPRCTLLSGGLDSSAITALAAAKLGE
                     RGEKVRSFAVDFTGREDDFVADELRATTDAPYAREVGAHVGSLHESVVLNHRDIADPAV
                     RRAVITARDSPLSLGDMDTSLYLLFQAIRQHSTVALSGESADEVFGGYRWFFQPEAQAA
                     ATFPWMAVFVSGAKAQVSDRFNADITAALDLPSYIRDRYAEALTEIERVDGESDHEFRM
                     REMCYLHLTRFVRMLLERKDRVSMAVGLEVRVPFCDHRLVEYVYNTPWSMKTFDGREKS
                     LLRAATADLLPRSVLDRVKAPYPATLDPMYTSALLQQCRDLLATDDPVFNLVDRAYLEG
                     ITRESGALPIEIRNGMERVLDLSTWLDIYRPELRF"
     gene            10001..10489
                     /locus_tag="JQN83_RS31930"
                     /old_locus_tag="JQN83_31925"
     CDS             10001..10489
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phenazine: phzB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF015255.5"
                     /locus_tag="JQN83_RS31930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31925"
                     /product="PhzA/PhzB family protein"
                     /protein_id="WP_208570871.1"
                     /sec_met_domain="phzB (E-value: 2.5e-65, bitscore: 211.1,
                     seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTETQLPGFTDQVDLRARNRATVTDYMSRKGENRLTRYLLFTED
                     GSAGLWTTDTGQPVASQGHELLRAHGEWSLRMFPDWEWTNVEIFETQDPNRFWVECDGE
                     GQIRYPAYPPGHYRNHFIHSFELDDGKIRRQREFMNPFQQLRALGIEVPTIDRGGIPT"
     gene            10499..10909
                     /locus_tag="JQN83_RS31935"
                     /old_locus_tag="JQN83_31930"
     CDS             10499..10909
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020519602.1"
                     /locus_tag="JQN83_RS31935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_31930"
                     /product="VOC family protein"
                     /protein_id="WP_208570872.1"
                     /transl_table=11
                     /translation="MTARLNPYIAFNGNAREALEFYREILGGELEIGTFTEYGASDVMA
                     ADKIMHAVLTTPDGFTLMAWDVPERVPFHPGNNVALYLGGDDPALRGYFQRLSVGGTVT
                     MPLNKQVWGDEAGSFIDQFGIFWMVNITRPKG"
ORIGIN
        1 agctcggcac gaaagccggg tagcagagcg acgcctccgt ggcggccgcg ctcggtgtag
       61 acgggcacgc cggcggcgga cagcgcttcg acgtcgcgca gcaccgtacg cgtggagacc
      121 tcgagttccc gcgccaaggt gtcgacggtc agctgaccac gctggcggag gagcagcatc
      181 agcgagacaa gccgatcggc gcgcacggga caactctagc cagggaccgc ccggaatacc
      241 tgacacaggg tgtcgtgatt acttgtgaca ctcgtcggca ggagctcgac atgccgcctg
      301 ttcgggcggc gggacgaacg cgtcctcgac cgagctcgtc ctcaattgag tctagggagt
      361 aactgtggca gcagagcgta tcgcggtcaa cccggtgaac tggtccctcg agatgggctt
      421 caaccagggt gaagtcgttt ctggtcagac ccggacgctg tacgtctcgg ggcagacgtc
      481 gatgagcccg gagggcaagc ccgagcacga cggcgacatc gccgcacagc tcgcgctgtg
      541 cgtcgacaac ctggaggccg tgctgaagga agcgggcatg accctggcga acctcatccg
      601 cttgaacgtc tacaccaccg acgtcgacca actgttcccc cactacggcg tgctcgccgg
      661 gcgactgggg tctgcgggtg tcgcgccgac cacgacgatg ctcggggtga cgcgcctggc
      721 gatccccggc cagctggtcg agctcgaggg caccgccgtc gcctgagccg acctcgccac
      781 gctcgctgct cgtgccggtt cgtccggcgc gggcagctgg cagattgggt gaccctggtg
      841 gccaagagcc tgccccccgg ctgggcgtcg cgactgcgac aactgacgga ccgtgtcggg
      901 cacgtgttcg cccgccccga gccccgcgtc gtcttccacg acctggtcga agggctgctg
      961 tcggacctgc cgaaaaagaa ctgctggtcc ttgtccgaac gggccgggca cagccacccg
     1021 ggccgaatgc aggcgctgtt gtcgcggggc gcgtggagcg ccgacgccct ggaggccgag
     1081 gtccgctcgt acgtcatcga gcacctgggt gacccggacg ccatgctcgt catccgcgac
     1141 gcccaggtga tcaagcgggg tgacaagtcc gtcggggtgg ggccgcagca ctgcacgctc
     1201 accaaccgca tcgagaactg ccaggtcgcg gtcatgctgg cgtacgccgc gcccgccggg
     1261 acggcgtacg tcgggcatcg gctccacctg ccgcgtacct ggatcgccga ctcggtgcgc
     1321 cgcacgaagg cgggcatccc cgccgacgtc gcgtacgcct cccggccgga gcaggccgtc
     1381 gagctgctgg cggaggcagt ggatgcggcg gtgccgttca gctgggtcag cctcgacgac
     1441 ggatacgccc aacatccgca ggtccgggac tggtgcgtgc agcgcgccct gccgtacatc
     1501 gcggccgtgc cggcgacgct acccctgatc agggtcggtg cgaccaggtc gtccaccacg
     1561 accggccccg aacagatcct cggccacatc gccgacagtt actggcaccg ccggaccgaa
     1621 cgggcgactg gacgcacgca cgactgggcg ctcgtcgggc tcggcggcag cctgctggtc
     1681 ggtggcgagg tccccacccg cgggttcgcc cagtcgctca tggtgcggcg gtcggtcgac
     1741 aacccgcacg atgtcgccta cttcgtggcc cacgcgcgcc gacgcacacc cgcgtccgtc
     1801 ctgatcggtg cggcggagcg gcgacaccgc gcggggcagc cggagcaacc cggcgacgaa
     1861 ctgatcggtc tcgaccagta ccaggtgcgc acctggaccg catggcacca cacgatcacc
     1921 acgtgcatgc tcgcccacgc gttccgcacg gtgcagcgcg caacggcacc cgatgcccgc
     1981 accgccgtcc gcaggccccg gcaggtcgcg gcctgccgcc ccggggtggg caccggggca
     2041 gcgagccacc cactgcgcag cggctcgggg cactagcgga cgtcgtgcgg gcggggccga
     2101 ccgggtaccg gtcggcccct cgggcggcgg caggggcggg gagccaggcc gtgacagcac
     2161 accggcggca ccgtccgaat cggaccatca ctctcatctg agttccagcc tggctgtcgt
     2221 catccggtat ttatgcccgg ttcacgacac gtgacatcac ctgcgccgaa ggaattcgca
     2281 aaacgccgcg aggccaccat gagtccaaga tccgcaactg tagtcgacaa cttcggccgg
     2341 cgcgttttgg gggcatcctt ccggaaggag aaaatcgagg gttcgcgttt tggctggtag
     2401 taagcacgag tcagcagcac aacgtcccac caagcgattc atgatgttga aatattgtcg
     2461 ccgcccgagc ttaatgcgtc ttgacagagc cagatgtggg ctgttgtatc aatgccatca
     2521 ggccgccgga acgacaaacc ggggaccatg aaacgtgccc gtaaatgacg gtcagatgag
     2581 cgactcaaac cctagtaacc acttccaatt agggggagac agtcatgcac gaaatcaagc
     2641 gcacgatacc cattgtcgcc gccggcggca tcctgctggc cgccggcacg ctcttcgggg
     2701 ccaactccgc ctatggccaa accgacacga acaatcccca gcagacacac gcgaatcact
     2761 ccgtcgacca ccgggcgcat gcccgcgtgc ccggattcgt cgcgccgacc accaccgccg
     2821 tgccgacccc cgccaccaac accgccgccc tccaggccgg cgcccagagc cccgccgagc
     2881 tgatcaatct cctcggtcag cggatcgtgg cgaaggacgt ggacgggatc gtcgcgctcc
     2941 aggagcgcga ggcagccatc atcgactggg acggatcggt cattcgcggg catgccgcca
     3001 ttcgcgcatt ctacgtcgag tggttcgaat cagacccgat cctccaggtg agcccgctcc
     3061 agatcgtgga ggccggcgga acacgcgtcg gaaacaaggt gattggccgt tcagcgtccg
     3121 tgatgggcac ctacacactc gaacaggacg ggcccgacgg cacccgggtg agcttctcgg
     3181 ggaacttttg cgacatcgtc cgccagcaac tgaacggcac ctggctctac atccaggaca
     3241 atccctaccc gccgcacagc tgatctgccc atccactgac cgcgtccctc tcacgcactc
     3301 caccgcccgt cggtaagtga gcccgtagcc gattagccag cctaatcggc tacgggccac
     3361 acccgaagta accagcgaat gccgagatgt ccgaggttgg gagagagtgt gaacaccatc
     3421 tcactcgatg ttccaccggt cgaggccgcc gagcagcaac ctgaatggga agacccggcg
     3481 caggtcgcgc aaatccgcga cgtcctggcg agccttcctc cactcatcga ggcggagtca
     3541 cttcccacgt tccagagttc actcgccgac gtcgccgccg ggcacgccca ggtactgcag
     3601 gccggtgact gtgccgagga ccctgcggaa tgcaccgcgg aacacgtcag gcgcaaggtg
     3661 gacctgctcg acgccctcgc cgccaccatg agcgccgcca ccggccgacc cgtcgtccgg
     3721 gtgggccgca tcgccggcca gtacgccaag ccacggtcga ggcccaccga acaggtcgac
     3781 ggcgtcgacc tgcccgtcta ccgcggccac ctggtcaacg atcctgcggc gacccgcccg
     3841 gcacgccggc ccgacccgca gcggctgctc gcgggatacc ggtcggcgag acggaccctc
     3901 agcgaactcg ggaccgtccg tgccgccggg gcgcccgtct ggaccagcca cgaggcactg
     3961 ctgctcgact acgaggtgcc gatgctgcgc cgtgaccgcg ccggccgggt cgcgctcacc
     4021 tccacccact ggccgtggat cggtgagcgg acccggcagc tcgacggtgc ccacgtcgcc
     4081 ctcctcgccc aggtggtgaa cccggtcgcg tgcaaggtcg ggccgacgat gacggtcgtc
     4141 gacctgctcg cgctgtgcgc acggctcgat ccgctacggg aaccgggacg cctcaccctg
     4201 atcgcccgac tgggcgccga cgtggtcgcc gaccggctac cgccgctcgt gcgggccgta
     4261 cgcgcggccg ggcacccggt ggtctggctg gtcgatcccc tgcacggcaa caccgtcacc
     4321 gcagccaccg gacgtaagac gcgcatcctg tcgaccatcc tccgggaggt caccgcgttc
     4381 cagatcgcgg tgcacgccga aggtggggtc gcgggcggcg tacacctcga gacgaccccc
     4441 gacgacgtga ccgagtgcct cgacgacggg cacagcagcg agccggcccg cctgcggtac
     4501 acctcgctct gcgacccgcg gctcaatccc cgccaggcgc agaccgtggt ctccgcctgg
     4561 cgggcgtcac ccctgacgaa ccgggctgag gagaaaccgt gccgggcctg acaccgatcg
     4621 ccgcctaccc gcttccgacc acgggcgaac tgcccgtcag catcgcgcag tggactcccg
     4681 acgccagccg ggcagcgctg ctcgtccacg acatgcagcg ttacttcctc ggcccgttcg
     4741 acccgtcggt acgcgaggca ctggtccgca actgcgtccg gttacgccag cggtgcggcg
     4801 aactccgcgt gccgacctat tacacggccc agcccggagg catgaccgag caggagcgcg
     4861 gcctgctcaa ggacatctgg ggtcccggga tgagcgggca acccggcgac cgggagatcg
     4921 tcaccgaact cgcgcccgga ccggcggacc acgtgctcac caagtggcgc tacagcgcgt
     4981 tccaccgttc ggacctgctg acccggctac gccggcaggg tcgcgaccag ctcatcgtct
     5041 gcggggtcta cgggcacgtc ggagtgctcg ccaccgccct cgacgcgttc accaacgaca
     5101 tccagccctt cctcgtcgcc gacgccatcg gtgacttctc cgccgaccac caccagttga
     5161 cgctcgacta tgcggccacg cgttgcgcgg tggtcaccac cacggaggag gtcttcccgt
     5221 gaacgcggcc cgcctgctcc ggcagctcgt cgatcccggc cgggaggcat tcgccctgct
     5281 gcaccgcccc gagtcggtgg gcggcgaccg ggtggagatc ctgtccggcc ggatcagcac
     5341 cgtcgcgcgg ctcgccgacg tcccactgcc cgacgccccg ctccacgagg ccgggccgga
     5401 cgacgaggcg ctgcacgaga cgctggtgct ggtgccccac cagcagatca ccgagcgggg
     5461 attcaccgcc gtcatggacg ggtcaccgct gatcaccctg tcggtgaccg aacagggctc
     5521 gatgaccagg gccgaagcgt tcgaacacct tccggacgac ccgatcagcc tcaccaacgg
     5581 cggcttcgac accgatgacg gcagctacgc cgacacggta cgtgcggtac tcgccaacga
     5641 gatcagcacc ggtgccggtg cgaacttcgt catcaagcgg tcgtacgtca ccaccgtcac
     5701 ggggtactcc ccgcgcacgg cgctgagcct gttccgccgg ctgctcgccc gggagaccgg
     5761 cgcctactgg accttcctcg tgcacaccgg cacccggacg ttcgtgggcg ccaccccgga
     5821 acggcacgtc agcctgcgtg gcggcgtggc ggcgatgacc ccgatcagcg ggacctaccg
     5881 ctacccgagg accggaccgg tcctggcgga ggttctcgac ttcctcaccg acggcaagga
     5941 gaccgacgag ctgtacatgg tcctcgacga ggagctcaag atgatggccc gggtgtgcga
     6001 cggcgggggc cgggtggtcg gcccgttcct gcggcagatg gcctggctcg cgcacaccga
     6061 gtacaacatc gagggcccca gcagcctgga cccccgggac atcctccggg agaccatgtt
     6121 cgccccgacc gtgacgggca gcccgttgga gaacgccttc cgggtgatcg cccgctacga
     6181 accgcacggc cgcggctact acggcggcat cgcggccctg atcggccggg acgccggtgg
     6241 cgcacggacc atggacgccg ccatcatgat ccgcaccgcc gacatccgtc cctcgcagac
     6301 cgacgacagc gcccgcgtcg aggtcggtgt cggtgccacg ctcgtccggc actccgatcc
     6361 cgacgccgag gtcgccgaga cccacgccaa ggccgccggg gtgctctccg cgttgggcat
     6421 cggcgaacgc ctcgacgggc acccactgat ccggcaggcg ctcgaccgcc gcaacacggc
     6481 gatcgcgagc ttctggctca gcgacgcgca gacccgcagg cggccgcagc ccgccctggc
     6541 cggccgccga gccctgatcg tcgatgccga ggacgccttc agcgcgatgc tggcccacca
     6601 gctacgggca ctcggcctgg cggtgcaggt ggcccgggcc gacacccgcc ccgggttcga
     6661 cgcccacgac ctcgtcgtcc tcggccccgg cccgggtgac ccgcgcgacg ccgccgatcc
     6721 acggatgagc cacctcaccg aggcgatcga ccagctcctc gcccggcgta ccccgttcct
     6781 ggcggtgtgc ctgagccacc agctgctgtg ccggcacctc ggcctgccgc tgcggcggcg
     6841 ggacatcccc aaccagggcg tccaacgtga gatcgacctg ttcggcaccc cggcacgggt
     6901 cggcttctac aactccttcg tcgcgtacgc gcggatggag cagttccaca gtcccagggc
     6961 gggcgaggtg cgcgtcagcc acgaccccac caccggtgag gtgcacgccc tacgcggagc
     7021 ccacttcagc tcggtgcagt tccacccgga gtcggtcctc acccaggacg gcgaacgcgt
     7081 gctgggcgac ctgctggcat cgctgacaca catcgaggag gtcatgaacg catgaaggcc
     7141 gccgtctcct ggtgggacct cgccgagtcc acccagacca tcgactcact gcgccactac
     7201 ctgcgcgagg agggcgtgca gccgtgggag cgggtgcacg gaatgcggct caagttctgg
     7261 atctccgacc gggagaccaa ccgctggggc gcggtcatgc tgtgggacgc caccgccgac
     7321 ctgaccgcgc cgctgccgcc gaaccgggcc accgagctga tcggataccc gcccaccgta
     7381 cggatgatga ccgaggtcga ggccatcgtg gaagggctgc acgccggacc gtccgacgac
     7441 cgtgggctgg cattcggacc ggtccggaac ccgtcgtgag tacgtcggca cagcagttgg
     7501 gcgtcgatgt cttcgccacc ccgcccgacg aaccgatggg gctgctgcgg agctggctgg
     7561 acgcggcacg ggcggacgcc gtccgcgagc ccggcgcgct ggcgctggcg accgccgacg
     7621 ccgacggtcg cccgtcgacc cggatggtgc aggtcctcgc cgtgcgcgac aacggactgc
     7681 tgttcgccac ccactccggc agtcgcaagg gccgggagtt ggcggcgaac cgctgggcgt
     7741 cgggtgtcct ctactggcgg gaggtggccc gccaggtggt cgtcggcggg ccgaccggcc
     7801 cgctgggagc cgacgaggcc gacgccctgt ggacggcccg gcccgtcgcc acccacccga
     7861 tgtcggtggc gtcgcagcag agcgcgcccc tcaccgacga ggacgcgttg cgcgagcagg
     7921 cgcggcggct cggcgaccgg ggcatgccgt tgccccgccc ggatgcctgg ctggcctacc
     7981 tgctggagcc ggattcggtc gagttctggg agtccgaccc gggccggttg caccgtcggc
     8041 tgcgcttcga ccgcgacggc accgggtggc ggtccggtcg ccttcaaccc tgaccacccg
     8101 gacagttcgc tcgagaggaa caggtagacg agatgtgtgg aattgcaggc tgggtctcgt
     8161 acgatcggga tctcacgcga caccaggccg acctggacgc gatgacggcg accatggcct
     8221 gccggggtcc ggacgcatcc ggtgtccagc tggaccggca cgccgggctc ggtcaccgca
     8281 ggctcgccgt gatcgacgtc gacggcggca cccagccgat ggcggtgcag accgacgacg
     8341 gcaccgtgac gatcacctac agcggcgagg cgtacaactt cggggagctg cgcggcgaac
     8401 tgcgacgccg cggtcaccgc ttccggaccc gcagcgacac cgaggtggtg ctgcacggct
     8461 acctggaatg gggcgaggcg gtcgccgaac ggctcaacgg catgtacgcc ttcgccgtgt
     8521 gggactcccg ggtcgacaag ctggtgctga tccgggaccg gctcggcgtc aagccgctct
     8581 actactaccg caccgacgac ggggtgctct tcggttccga gcccaaggcg atcctcgcca
     8641 acccgctggc cgaacgtgcc gtcgacctgg cggggatccg ggaactggtc agcttcaccc
     8701 agacgcccgg cagcgccgtc tggtgcggga tgaacgaggt gctacccggc ggggtcgtca
     8761 ccgtcgaccg cgccgggctg cgcgagcacc gctactggac gctgccgagc cgcccacaca
     8821 ccgacgacct gccgaccacc atcgccaacg tccgctcgtt gctcagggac gtggtggaac
     8881 gccaactggt ctccgacgtg ccgcgctgca ccctgctgtc cggcgggctc gactccagcg
     8941 cgatcaccgc cctcgccgcc gccaagctcg gcgaacgcgg tgagaaggtg cgcagcttcg
     9001 cggtggactt caccggacgc gaggacgact tcgtcgccga cgagctgcgc gccaccaccg
     9061 acgccccgta cgcgcgggag gtgggcgcgc acgtcggctc gctgcacgag tcggtggtcc
     9121 tcaaccaccg ggacatcgcc gaccccgcgg tccgacgggc ggtgatcacc gcccgggaca
     9181 gtccgctcag cctcggcgac atggacacct cgttgtacct gctgttccag gcgatccgtc
     9241 agcactccac ggtggccctg tccggggagt ccgccgacga ggtcttcggc ggctaccggt
     9301 ggttcttcca accggaggcc caggccgcgg cgaccttccc ctggatggcg gtgttcgtca
     9361 gcggcgcgaa ggcccaggtg tcggaccggt tcaacgccga catcacggcc gccctcgacc
     9421 tgcccagcta catccgggac cggtacgccg aagcgctcac cgagatcgag cgggtcgacg
     9481 gcgagagcga ccacgagttc cggatgcgcg agatgtgcta cctgcacctg acccgcttcg
     9541 tcaggatgct gctcgaacgc aaggaccggg tcagcatggc cgtcggtctg gaggtccggg
     9601 tgccgttctg cgaccaccgg ctggtcgagt acgtctacaa caccccgtgg tcgatgaaga
     9661 cgttcgacgg gcgggagaag agcctgctgc gggccgcgac cgccgacctg ctcccccgtt
     9721 cggttctcga ccgggtgaag gccccgtatc cggccacgct cgacccgatg tacacgagcg
     9781 ccctgttgca gcagtgcagg gacctgctcg ccaccgacga cccggtgttc aacctggtcg
     9841 accgcgccta cctggagggc ataacccgtg agtcgggcgc cctgccgatc gagatccgca
     9901 acggcatgga gcgggtgctc gacctgagca cctggctgga catctaccgc cccgagcttc
     9961 ggttctgacc tgaccgccac cggctgagaa gggacttccg ttgacgaccg agacccagct
    10021 tccggggttc accgaccagg tggacctgcg ggcccgcaac cgcgcgaccg tcaccgacta
    10081 catgagccgc aagggcgaga accggctgac ccgctacctg ctgttcaccg aggacggcag
    10141 cgccggcctg tggaccaccg acaccggcca gccggtcgcc tcccagggcc acgaactgct
    10201 ccgggcgcac ggcgagtggt cgctgcggat gttccccgac tgggagtgga cgaacgtcga
    10261 gatcttcgag acgcaggacc cgaaccggtt ctgggtcgag tgcgacggcg agggtcagat
    10321 ccgctacccg gcgtacccgc ccgggcacta ccgcaaccac ttcatccact cgttcgagtt
    10381 ggacgatgga aagatccgcc gccagcggga attcatgaac ccgttccagc agctccgggc
    10441 gctgggcatc gaggtgccga cgatcgaccg cggcggaatc cccacctagg agcagcagat
    10501 gaccgctcgg ctcaacccgt acatcgcctt caacggcaac gcccgggagg cactggagtt
    10561 ctaccgtgag atcctcggcg gtgagttgga gatcggcacg ttcaccgagt acggcgcgtc
    10621 cgacgtgatg gccgccgaca agatcatgca cgcggtgctc accaccccgg acggtttcac
    10681 cctgatggcc tgggacgtcc ccgaacgggt gccgttccac ccgggcaaca acgtcgccct
    10741 ctatctcggc ggcgacgatc ccgcgttgcg cgggtacttc cagcggctgt cggtcggagg
    10801 cacggtgacg atgccgctca acaagcaggt gtggggcgac gaggccggct cgttcatcga
    10861 ccagttcggg atcttctgga tggtcaacat cacccggcca aagggctgac cggccacacc
    10921 tgacggatcc ggcacgccag cccccgttac ctttttgatc gtccccagcc ggggaccctc
    10981 ggtcgcccgg cccggtatga ctttctgccc ctgtcgtttg catgatccgg ggggtgttgt
    11041 cgccgggtcg ggtggcgtcg gcg
//
