LOCUS       NZ_JAGFWR010000021     11312 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Micromonospora antibiotica strain MMS20-R2-23 contig21, whole genome
            shotgun sequence.
ACCESSION   NZ_JAGFWR010000021
VERSION     NZ_JAGFWR010000021.1
KEYWORDS    WGS; RefSeq.
SOURCE      Micromonospora antibiotica
  ORGANISM  Micromonospora antibiotica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 111393)
  AUTHORS   Lee,D.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2021) Microbiology & Molecular Biology, Chungnam
            National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, South
            Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 79.63x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017599305.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 02:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,561
            CDSs (total)                      :: 6,498
            Genes (coding)                    :: 6,378
            CDSs (with protein)               :: 6,378
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 20 of 120
            Pseudo Genes (incomplete)         :: 107 of 120
            Pseudo Genes (internal stop)      :: 2 of 120
            Pseudo Genes (multiple problems)  :: 9 of 120
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:14:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 100081
            Orig. end                         :: 111393
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAGFWR010000021.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11312
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene-precursor"
                     /region_number="2"
                     /rules="(PT_FPPS_like and not PT_HPP)"
                     /tool="antismash"
     cand_cluster    1..11312
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_FPPS_like and not PT_HPP)"
                     /kind="single"
                     /product="terpene-precursor"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11312
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[10000:11083](+)"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11083
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PT_FPPS_like and not PT_HPP)"
                     /neighbourhood="10000"
                     /product="terpene-precursor"
                     /protocluster_number="1"
     gene            394..930
                     /locus_tag="JQN83_RS25850"
                     /old_locus_tag="JQN83_25845"
     CDS             394..930
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020511934.1"
                     /locus_tag="JQN83_RS25850"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25845"
                     /product="FMN-binding protein"
                     /protein_id="WP_208569753.1"
                     /transl_table=11
                     /translation="MRRITIWLLSTVTALVLLFSYRTSTMGVGGGTSAVAVDRGGTTPG
                     SGDTPTGTGPGSGVPGGDTGEGANTGQGGNTGDSASTGDSGGGSYDGSVAQTRWGPVQV
                     RITVAGGRITDVTALQVPDGNFRDQQINDYAVPILRQAALTAQSARIDTVSGATVTSDG
                     YRESLQAAIDAAHLR"
     gene            927..1751
                     /locus_tag="JQN83_RS25855"
                     /old_locus_tag="JQN83_25850"
     CDS             927..1751
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017013 - protein flavinylation [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014477.5"
                     /locus_tag="JQN83_RS25855"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25850"
                     /product="FAD:protein FMN transferase"
                     /protein_id="WP_208569754.1"
                     /transl_table=11
                     /translation="MSTPTGRTVELDRRAWVVQVMGLPVSVHLRGPDVHDDAVAARVER
                     FFTWLRAADATFSTYRPESEIGRLAGREPDPATASPLVREVAELCELARTRTGGRFDAR
                     RLPLPTGGAGYDPSGLVKGWAVQRAAGWLADLAGHDLCLNAGGDVVLHAGADRPAWRVG
                     IEDPDRPGHLLDVLDRRDGAVATSGTARRGAHIVDPRTGRPATALRSVTVVGPDLLWAD
                     VYATAAMTRDADDALTWLTGLADHEALLVTADGRIRATGHWPGTRPGSPPAR"
     gene            1811..2299
                     /locus_tag="JQN83_RS25860"
                     /old_locus_tag="JQN83_25855"
     CDS             1811..2299
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018742850.1"
                     /locus_tag="JQN83_RS25860"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25855"
                     /product="YbaK/EbsC family protein"
                     /protein_id="WP_208569755.1"
                     /transl_table=11
                     /translation="MQSHPNVQAVQRALDEAGARDGSGAASRVRLLPEAAHTAAAAADA
                     LGVTVGAIANSLVFEADGTPLLVLTSGAHRVDTAGLAAQLGVTHLRRATPDFVREHTGQ
                     VIGGVAPVGHPGPLRTLVDTALTGHPQVWAAGGVPQAVFPTTYPELLRITGGTPAEVA"
     gene            2296..3015
                     /locus_tag="JQN83_RS25865"
                     /old_locus_tag="JQN83_25860"
     CDS             2296..3015
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007463074.1"
                     /locus_tag="JQN83_RS25865"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25860"
                     /product="monooxygenase"
                     /protein_id="WP_208569756.1"
                     /transl_table=11
                     /translation="MNTTPELVTLHVWRVPRAAVGRALARMARHPWQLRRTPGVRFGKL
                     LGTGTGTGFGPGDADLTRWAALVVWESPAAAAGFDASPVGRSWARIAHASARLELRPVT
                     SRGEWSGRRPFGDPAGGRVDGPVLALTRARLRPRRALTFWRAVPPVAAALHAAPGLLAR
                     FGVGEAPLGWQGTVSVWRDPTDLVAFAYRHPEHRAAITRTPTEGWYAEELFARFEVRAV
                     VGDRSVLGWVADGDPQP"
     gene            3026..3595
                     /locus_tag="JQN83_RS25870"
                     /old_locus_tag="JQN83_25865"
     CDS             3026..3595
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0008080 - N-acetyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018807935.1"
                     /locus_tag="JQN83_RS25870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25865"
                     /product="GNAT family N-acetyltransferase"
                     /protein_id="WP_208569757.1"
                     /transl_table=11
                     /translation="MRLVRWTPEDLVRRLDDVVAVYGEAMGYRSDLLEARRGYIATHAR
                     RPGFRAVASLTSEGHLAGFGYGYLGAGGQWWHDQVYRALDPDARQRWLTHCFEVVELHV
                     RPPAQGHGLGARQLTALLSIAEGGTTLLSTPEADEQASRAWRLYRRFGFVDVLRHFRFP
                     GDERPFGVLGRDLPLPRPDTSGPASS"
     gene            3592..4518
                     /locus_tag="JQN83_RS25875"
                     /old_locus_tag="JQN83_25870"
     CDS             3592..4518
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013735113.1"
                     /locus_tag="JQN83_RS25875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25870"
                     /product="carotenoid biosynthesis protein"
                     /protein_id="WP_208569758.1"
                     /transl_table=11
                     /translation="MTRRHVPWLLLALLVLIQICYPLTTGVTRARLTVATVVLGYLLSV
                     GHALLTRGARTAAALVAVATGGGFAIEALGVATGFPFGSYDYSGELGPKLAGVPLIIPL
                     AWTWMAWPAWLAAVRLTTRAGRLTTSAGRMPGTASTTGRMPGTVSTAGRTPGTLTPAGH
                     VGRVALATVGLAGWDLFLDPQMVAEGYWVWRDATPALPGLPGIPVSNYLGWLLFAVLLM
                     SALRPLAGPAVAVTDSRDDPMFALYLWTYFSSVLAHAVFLRLPASALWGAVGMAVVAVP
                     LAVTLLRARRRPADRPAPRRRGVDTPA"
     gene            4619..5743
                     /locus_tag="JQN83_RS25880"
                     /old_locus_tag="JQN83_25875"
     CDS             4619..5743
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013475766.1"
                     /locus_tag="JQN83_RS25880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25875"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_208569771.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.1e-13,
                     bitscore: 44.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVALVLAVAVTALTAHTWVNARYWLRRPADGPVGVNETVAVLLPL
                     RDEADRVTPCLRALLAQQGVSDLRIVVLDDGSTDGTAGVVRAVVGDDPRVTLHTGVTPP
                     PGWLGKPYACHQLAGHAGPDATVYAFVDADVVLTPYAVAAAVTELRAARATLLSAYPRI
                     LVRTVGDRLVQPLLQWLWLTFLPLRAMERSPRPSLAAAGGQFLLVDRAGYERAGGHAAV
                     ADRVLEDIELARAVKRAGGRIALADGSRLAACRMYETWPQLRDGYTKSLWATFGHPGAA
                     ATVVAALLLLYTAPPLLAVTALAAGSPPAAGLALTGYAVGVAGRVVAARATGGRAWPDA
                     LAHPGSVVVLGWLTLRSYHLRKRRRLSWRGRPVS"
     gene            5754..7241
                     /locus_tag="JQN83_RS25885"
                     /old_locus_tag="JQN83_25880"
     CDS             5754..7241
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012014459.1"
                     /locus_tag="JQN83_RS25885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25880"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_208569759.1"
                     /sec_met_domain="DAO (E-value: 3.3e-11, bitscore: 35.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARIVVIGAGVGGLATAARLAVSGHEVTVFERSDTVGGKLGRYVH
                     DTPAGSFHFDTGPSLLTLPQVFHDLFEATGAKLDEYLDLTPLDPIVRHVFPGGGPALDS
                     CADPDEFAARIGVALGDRAAADWRRLWRRAARVWTASHRDILRRTVDSPRDLAALAWRL
                     GDLAAIGPGRTLRGLGRSHLSDPRLRMLLDRYATYTGADPRRAPAALVAVPYAELTFGG
                     WYLRGGLGTLADALLSRCLDLGVTVRTGETVTRIDAAGGRVHGVRLAGVHAPVPADVVV
                     ANADALTVYRDLLPHPGRLAALTDRSLAGFVLLLGVRGDSGLAHHNVFFPTDYHAEFDA
                     VFGDPGRGVRARPATDPTIFVTVADDPTARPTGHEAWFVLVNAARHGTAPDAVNWRRPG
                     LADAYADRILDVLAARGVDVRDRLVFRETRTPADLDAATAAPGGSIYGTAGGLLRPANR
                     GPVHGLWLVGGSTHPGGGLPMVTLSAQIVADEIGPAW"
     gene            complement(7278..7967)
                     /locus_tag="JQN83_RS25890"
                     /old_locus_tag="JQN83_25885"
     CDS             complement(7278..7967)
                     /EC_number="2.7.8.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /GO_process="GO:0008654 - phospholipid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287633.1"
                     /locus_tag="JQN83_RS25890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25885"
                     /product="CDP-alcohol phosphatidyltransferase family
                     protein"
                     /protein_id="WP_208569760.1"
                     /transl_table=11
                     /translation="MVGTQLKWDEYATAWARLHGGFDPRVAAPVVRAWLRFAYHVGYVL
                     GRLRVTPTAVTVGGVLLCLCVPLFSVRSAQGPIVGALFVLLASVADSVDGAVAVATGRT
                     TRLGYVYDSVADRLGEIAWLAAFWLIGAPGALVVAAGALSWLHEYVRARAVAAGMREIG
                     AVTVGERPTRVCVALVGLLLAGLTGLIDLDLTAGTITMATAVWVLLAGFGLGQLLSTVR
                     RALLDAG"
     gene            complement(8012..8929)
                     /gene="metF"
                     /locus_tag="JQN83_RS25895"
                     /old_locus_tag="JQN83_25890"
     CDS             complement(8012..8929)
                     /EC_number="1.5.1.20"
                     /GO_component="GO:0005829 - cytosol [Evidence IEA]"
                     /GO_function="GO:0004489 - methylenetetrahydrofolate
                     reductase (NAD(P)H) activity [Evidence IEA]"
                     /GO_process="GO:0009086 - methionine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="metF"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018785290.1"
                     /locus_tag="JQN83_RS25895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25890"
                     /product="methylenetetrahydrofolate reductase [NAD(P)H]"
                     /protein_id="WP_208569761.1"
                     /transl_table=11
                     /translation="MALGLPSVLPNPQPAIGELIRARQPTFSFEFFPPKTAQGERLLWQ
                     AIRELESLRPSFVSITYGAGGSTRDTTVAVTERIATETTLLPMAHLTAVNHSVAELRNV
                     IGRLAGVGVRNVLAVRGDPPGDPGGEWIRHPEGVDYAEDLVRLVREAGDFSVGVAAFPY
                     KHPRSADVDSDTAHFVRKCRAGAEFAITQMFFDADDYLRLRDRVAAAGCDTPILAGVMP
                     VTQIGTIERSVQLSGAPFPPALAERFARVADDPEAVRRLGIEQASEMCARLLDEGVPGI
                     HFITLNRSPATREVWRSLRADARV"
     gene            9214..9966
                     /locus_tag="JQN83_RS34390"
                     /old_locus_tag="JQN83_25895"
     CDS             9214..9966
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.5"
                     /locus_tag="JQN83_RS34390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25895"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_208569762.1"
                     /transl_table=11
                     /translation="MTPSDPSLLGPLIAQLRLARGWSQQRLADELCATAGTPTLTRHEV
                     SRWERAVRVPGDRWRRQLAVVLDAPIGSLAGGPPRDRKAAPTRRADPTRRADPTRRADP
                     TRRATPTRQTDPTRPATPTRQAAPTRRATPTRQAAPKPTRAGNAAPGRWIEPGPDGPTP
                     QRRRTGPTPGKGPGSGGGPVSGGGPVSGGGPVSGGGPVLGKGPVSGGGPVSGKGPGSGN
                     GPCRPAGHPGRPVGRGRGGDRDDAPSRW"
     gene            10001..11083
                     /locus_tag="JQN83_RS25905"
                     /old_locus_tag="JQN83_25900"
     CDS             10001..11083
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene-precursor: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007072192.1"
                     /locus_tag="JQN83_RS25905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_25900"
                     /product="polyprenyl synthetase family protein"
                     /protein_id="WP_208569763.1"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.8e-50, bitscore:
                     164.2, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHAAPVSPVDRAGLRQRVDKALTEFLSGRRSWMAGIDEALAPVA
                     EAIEGFVLGGGKRLRPAFAYWGFRGAGGVDADPVVTALAALEFFQASALIHDDLMDRSD
                     TRRGEPAVHRRFATRHRASGWHGDPDSFGDAAAILLGDLCLVWSDELLHSAGLAPHTVA
                     RARPVFDEMRGEVTVGQYLDVLTQATGEVSLERAGKVARYKSAKYTVERPLLLGAALAD
                     ASPDVRTAYSAYGLPLGEAFQLRDDVLGVFGDPAQTGKPAGDDLREGKRTYLVAAAVEV
                     ADEAGRDLLLSRLGDPELDEDGVARLRELISATGALARTEQRIVTLTDTALAALAGVDL
                     DTEARQALVDLAIAATRRAD"
ORIGIN
        1 cctgcgggat cggcgtcacc ccgctgctgg ccctgctccg ggagctgccg tacgcacccg
       61 ggcaggcggt gctgctctac cgcgtgcgta ccccgcagga gctggccttc cgggcggagc
      121 tggagcagct cgcggtcgac cgcggggtgt cggtccacta cctggtcggt ccgcgcggcc
      181 ggcaaccctc ctggctaccc ggttacgcgg ccgggctccc ggacgccgag gcgctgcgcc
      241 ggctctcccc cggcatcgcc gaccacgacg tctacctgtg cggcccggac ggttgggtcg
      301 acgcggtgca ggccgcgacc cgggccgccg gggtgcccga gcggcacgtc catcacgaac
      361 gcttcgcctg gtgacgggcg ggaaggggga accgtgcgac ggatcaccat ctggctgctc
      421 tccacggtga ccgccctggt gctgctgttc agctaccgga ccagcaccat gggcgtcggc
      481 ggggggacca gcgccgtcgc cgtcgaccgc ggcggcacca cccccggctc cggggacacg
      541 cccaccggca ccggcccggg ctcgggcgtg ccgggcggag acaccggcga gggcgcaaac
      601 accggccagg gtggaaacac cggcgacagc gcaagcaccg gcgacagcgg cggcggaagc
      661 tacgacgggt cggtggcgca gacccggtgg gggccggtgc aggtccggat caccgtggcg
      721 ggcgggcgga tcaccgacgt cacagcgctc caggtgcccg acggcaactt ccgggaccag
      781 cagatcaacg actacgcggt accgatcctg cggcaggcgg cgctcaccgc gcagagcgcc
      841 cggatcgaca ccgtgtccgg ggcgaccgtc accagcgacg gttaccgcga gtccctccag
      901 gccgccatcg acgcggcgca cctgagatga gcacgccgac gggccggacg gtggagctgg
      961 accggcgggc ctgggtggtg caggtgatgg ggctgccggt gagcgtgcac ctgcgcggcc
     1021 cggacgtgca cgacgacgcg gtcgccgccc gggtggagcg gttcttcacc tggctgcgcg
     1081 cggccgacgc gacgttcagc acctaccggc cggagagcga gatcggacgg ctggccgggc
     1141 gggaacccga tccggccacc gcgagcccgc tggtgcggga ggtggcggag ctgtgcgagc
     1201 tggcccggac gcgcaccggc ggccggttcg acgcccggcg gctgccgctg cccaccggcg
     1261 gtgccggcta cgacccgtcc gggctggtca aggggtgggc ggtacagcgg gcggccgggt
     1321 ggctggccga tctggccggg cacgacctct gtctcaacgc cggtggggac gtggtgctgc
     1381 acgccggggc ggaccggccg gcctggcggg tcggcatcga ggacccggac cgccccggcc
     1441 acctgctgga cgtgctggac cggcgcgacg gcgcggtcgc cacctcgggc accgcccggc
     1501 gcggcgcgca catcgtggac ccgcgtaccg gccgaccggc gaccgcgctg cggtcggtca
     1561 ccgtggtcgg gccggacctg ctctgggccg acgtgtacgc caccgcggcg atgacccgcg
     1621 acgccgacga cgcgctgacc tggctgaccg gcctggccga ccacgaggcg ctgctggtga
     1681 ccgccgacgg ccggatccgg gccaccgggc actggcccgg cacccgtccc gggtcgccgc
     1741 ccgcccgctg acccgccacg gtgggcggcc gggtgcgggg tgtcggggcg taccggggag
     1801 aatgggccgc atgcagtcac acccgaacgt gcaggcggtg cagcgggcgc tcgacgaagc
     1861 gggcgcgcgg gacggttccg gtgcggccag ccgggtccgt ctgctacctg aggcggcgca
     1921 caccgccgcc gcggcggccg acgcgctcgg cgtcaccgtc ggcgcgatcg ccaactcgct
     1981 ggtcttcgag gccgacggca cgccgctgct ggtgctcacc tccggcgcgc accgggtcga
     2041 caccgccggc ctggccgccc agctcggggt gacccacctg cgccgggcca cccccgactt
     2101 cgtccgggag cacaccggcc aggtgatcgg cggggtcgcc ccggtcggcc accccgggcc
     2161 gctgcgcacc ctcgtcgaca ccgccctgac cgggcacccg caggtgtggg ccgccggtgg
     2221 cgtaccgcag gcggtcttcc ccaccaccta cccggagctg ctgcggatca ccggcggcac
     2281 ccccgccgag gtggcgtgaa caccaccccg gagctggtca ccctgcacgt gtggcgggtg
     2341 ccccgggccg ccgtcggtcg ggcgttggcc cggatggccc ggcatccgtg gcagctgcga
     2401 cgcacccccg gcgtacggtt cggcaagctg ctcggcaccg ggaccggcac cggcttcggc
     2461 ccgggggacg ccgacctgac ccggtgggcg gcgctggtgg tgtgggaatc ccccgccgcg
     2521 gcggccggct tcgacgcctc cccggtcggc cgttcctggg cccggatcgc ccacgcgtcg
     2581 gcccggctgg agctgcgccc ggtgaccagc cggggcgagt ggtcgggccg acggccgttc
     2641 ggcgatccgg cgggcggccg ggtcgacggg ccggtgctgg cgctgacccg ggcccggctg
     2701 cgtccccgcc gggcgctcac cttctggcgg gccgtcccgc cggtcgccgc cgcactgcac
     2761 gccgcgccgg ggctgctcgc ccggttcggt gtcggtgagg ccccgctggg ttggcagggc
     2821 acggtcagcg tgtggcgcga cccgacggac ctcgtggcct tcgcgtaccg tcacccggag
     2881 caccgcgcgg cgatcacccg cacccccacc gaagggtggt acgcggagga gttgttcgcg
     2941 cgcttcgagg tgcgcgcagt ggtcggggac cggtcggtgc tgggctgggt cgccgacggt
     3001 gatccgcaac cgtgagagga cgcgcatgag gttggtgcgg tggacgccgg aggatctcgt
     3061 ccggcggctc gacgacgtgg tcgcggtgta cggggaggcg atgggctacc gcagcgacct
     3121 gctggaggcc cgacgcggct acatcgccac ccacgcccgc cggcccgggt tccgcgccgt
     3181 cgccagcctc accagcgagg gccacctggc cggcttcggg tacggctacc tcggcgcggg
     3241 tggacagtgg tggcacgacc aggtctaccg ggcgctggac ccggacgccc ggcagcgctg
     3301 gctgacccac tgcttcgagg tggtcgagtt gcacgtccgg ccgcccgcgc aggggcacgg
     3361 cctgggcgcc cggcagctca ccgccctgct cagcatcgcc gagggcggca ccaccctgct
     3421 gtccaccccg gaggccgacg agcaggcgtc gcgggcctgg cggctctacc ggcggttcgg
     3481 cttcgtcgac gtgctgcggc acttccgctt ccccggcgac gaacgaccgt tcggggtgct
     3541 cggccgggac ctgccgctgc cccgacccga cacgtccggc ccggcctcgt cgtgacccgc
     3601 cggcacgtcc cgtggctgct gctggccctg ctggtgctga tccagatctg ctacccgctc
     3661 accaccgggg tcacccgggc ccggctcacc gtcgccacgg tcgtgctggg ttacctgctg
     3721 tcggtggggc acgcgctgct cacccggggt gcccgtacgg cggcggcgct ggtcgcggtg
     3781 gccaccggcg gcgggttcgc catcgaggcg ctgggggtgg cgacgggctt cccgttcggc
     3841 agctacgact actcggggga gttggggccg aagctggccg gggtgccgtt gatcatcccg
     3901 ctggcctgga cctggatggc ctggcccgcc tggctggccg ccgtccggct gaccacgcgc
     3961 gccggccgac tgaccacgtc cgccggccgg atgcccggca ccgcgtcgac caccggccga
     4021 atgcccggca ccgtgtcgac cgccggccgg acgcccggca ccctgacgcc ggcggggcac
     4081 gtcgggcggg tggcgttggc caccgtcggg ctggccggct gggacctctt cctcgacccg
     4141 cagatggtgg ccgagggcta ctgggtgtgg cgcgacgcca ccccggcgct gcccggactg
     4201 cccggcatcc cggtcagcaa ctacctgggc tggttgctgt tcgcggtgct gctgatgagc
     4261 gcgctgcgcc cgctggccgg gccggccgtc gcggtcaccg actcccgcga cgacccgatg
     4321 ttcgccctct acctgtggac gtacttctcc agcgtgctgg cgcacgcggt cttcctccgg
     4381 ctgcccgcct cggcgctctg gggtgcggtg ggcatggcgg tggtggcggt gccgctggcg
     4441 gtgaccctgc tgcgcgcccg ccgacggccc gccgaccggc cggcaccgcg gcggcgcggc
     4501 gtcgacaccc cggcatgagc ggcacccgcc ccggccgacc cgccccgcca ccgcgccggc
     4561 acccgacgcc gggacgacga ccgcacccgg cctggtcggt gggggcgcgg cggtgaccgt
     4621 ggtcgcgctc gtgctcgccg tcgcggtgac cgcgctgacc gcgcacacct gggtcaacgc
     4681 ccggtactgg ctgcgccggc ccgccgacgg gccggtcggg gtcaacgaga cggtggcggt
     4741 gctgctgccg ctgcgcgacg aggccgatcg ggtcaccccg tgcctgcgcg cgctgctcgc
     4801 ccaacagggg gtgtccgacc tgcggatcgt ggtgctcgac gacggttcga ccgacggcac
     4861 cgccggggtg gtccgcgcgg tcgtcggtga cgacccccgg gtcaccctgc acaccggggt
     4921 caccccgcca ccgggctggc tgggcaagcc gtacgcctgc caccagctcg ccgggcacgc
     4981 cggaccggac gccaccgtgt acgccttcgt cgacgcggac gtggtgctca ccccgtacgc
     5041 ggtggcggcg gcggtgaccg agctgcgggc ggcgcgggcg acgctgctgt cggcgtaccc
     5101 gaggattctg gtgcggacgg tgggtgaccg gctggtgcag ccgctgttgc agtggttgtg
     5161 gttgaccttc ctgccgctgc gcgcgatgga acgctcgccg cggccgtcgc tggccgccgc
     5221 cggtgggcag ttcctgctgg tggaccgggc cggctacgag cgggccggcg ggcacgccgc
     5281 agtcgccgac cgggtgctgg aggacatcga gctggcccgc gcggtgaaac gcgcgggcgg
     5341 ccggatcgcg ctggccgacg gctcccggct ggccgcctgc cggatgtacg agacctggcc
     5401 gcagctgcgc gacggctaca ccaagtcgct ctgggccacc ttcggccacc cgggggccgc
     5461 cgcgaccgtg gtcgccgcgc tgctgctgct ctacaccgcg ccaccgctgc tggcggtgac
     5521 ggcgctggcg gcgggttcac cgccggccgc cgggctggcc ctgaccgggt acgcggtggg
     5581 agtcgccggg cgggtggtcg ccgcccgcgc caccggcggc cgggcctggc ccgacgcgct
     5641 ggcccacccc ggctcggtcg tggtgctcgg ttggctgacc ctacggtcgt accatctgcg
     5701 gaagcggcgt cgcctgtcct ggcgtggccg cccggtcagc taggaggcgc ggcatggcgc
     5761 ggatcgtggt catcggcgcc ggcgtgggcg ggctggccac cgccgcccgg ctcgccgtca
     5821 gcgggcacga ggtgaccgtc ttcgaacggt ccgacaccgt cggcggcaaa ctcggcaggt
     5881 acgtccacga caccccggcc ggcagcttcc acttcgacac cgggccgagc ctgctcaccc
     5941 tgccgcaggt cttccacgac ctgttcgagg ccaccggcgc gaaactcgac gagtacctcg
     6001 acctgacccc gctggacccg atcgtgcggc acgtcttccc cggcggcggg ccggccctcg
     6061 actcgtgcgc cgacccggac gagttcgccg cccgcatcgg cgtcgccctc ggcgaccggg
     6121 ccgccgccga ctggcggcgg ctgtggcggc gggccgcccg ggtgtggacc gcatcgcacc
     6181 gggacatcct gcggcgtacc gtcgactcgc cgcgcgacct ggcggcgctg gcctggcggc
     6241 tgggtgacct ggccgccatc gggcccggcc gcaccctgcg cgggctgggc cgcagccacc
     6301 tgtccgaccc ccggctgcgg atgctgctcg accggtacgc cacctacacc ggcgcggacc
     6361 cacgccgggc cccggccgcg ctggtcgccg tcccctacgc cgagctgacc ttcggcggct
     6421 ggtacctgcg cggcgggctg ggcaccctgg ccgacgcgct gctgtcccgc tgcctggatc
     6481 tgggcgtgac ggtccgcacc ggggagaccg tcacccggat cgacgccgcc ggtggccggg
     6541 tgcacggggt acgcctcgcc ggggtccacg cgcccgtccc cgccgacgtg gtcgtcgcca
     6601 acgccgacgc gctcaccgtc taccgggacc tgctgccgca cccggggcgg ctggccgccc
     6661 tcaccgaccg cagcctggcc ggtttcgtgc tgctgctcgg ggtacgcggc gactccgggc
     6721 tggcccacca caacgtcttc ttccccaccg actaccacgc cgagttcgac gccgtcttcg
     6781 gtgaccccgg gcggggggtg cgggcccgac cggcgaccga cccgacaatc ttcgtcaccg
     6841 tggccgacga cccgaccgcc cgcccgaccg ggcacgaggc gtggttcgtg ctggtcaacg
     6901 ccgcacgcca cggcaccgcc ccggacgccg tcaactggcg tcggccgggg ctcgccgacg
     6961 cgtacgccga ccggatcctc gacgtgctcg ccgcgcgcgg ggtcgacgtc cgcgaccggc
     7021 tggtgttccg cgagacccgt acccccgccg acctggacgc cgcgaccgcc gcgcccggcg
     7081 ggtcgatcta cggcacggcc ggtgggctgc tccgccccgc caaccggggg ccggtgcacg
     7141 ggttgtggct ggtcggcggc tccacccacc ccggcggcgg cctgcccatg gtcaccctgt
     7201 cggcgcagat cgtcgccgac gagatcggcc ccgcctggta ggccaccgcc cctgcccggc
     7261 ccgtcggggc gggcgggtca gccggcgtcg agcagggcgc ggcggacggt ggacagcagc
     7321 tgccccaggc cgaagccggc cagcagcacc cagacggcgg tggccatggt gatggtgccg
     7381 gcggtcaggt cgaggtcgat gagcccggtc aacccggcca gcagcagccc gaccagggcg
     7441 acgcagaccc gggtgggccg ctcccccacg gtgaccgcac cgatctcccg catcccggcg
     7501 gcgaccgcgc gggcccgcac gtactcgtgc agccaggaca acgcgccggc cgcgaccacc
     7561 agcgcaccgg gcgctccgat cagccagaac gccgccaacc aggcgatctc accgagccgg
     7621 tcggcgaccg agtcgtagac gtagccgagc cgggtggtcc ggccggtggc gaccgcgacc
     7681 gccccgtcga cactgtcggc gaccgaggcc aacagcacga acagcgcgcc gacgatcggg
     7741 ccctgcgccg accggacgct gaacagcggc acgcacaggc agagcagcac cccgccgacg
     7801 gtcaccgcgg tcggggtcac ccgcagccgt cccagcacat agccgacgtg gtacgcgaaa
     7861 cgcagccagg cccggaccac cggcgccgcg acccgggggt cgaagccgcc gtgcagccgc
     7921 gcccacgcgg tcgcgtactc gtcccatttc agctgtgtgc ccaccatcgg tcaaccgtcg
     7981 cggcctggtc gaggtgtcgg ggtcgacgcg ttcacacccg ggcgtcggcc cgcaggctgc
     8041 gccacacctc ccgggtcgcg ggagaacggt tgagggtgat gaagtggatg ccgggcaccc
     8101 cctcgtcgag caaccgggcg cacatctcgc tggcctgttc gatgccgagc cggcggaccg
     8161 cctccgggtc gtcggcgacc cgggcgaacc gctcggccag cgcgggcggg aagggcgctc
     8221 cggacaactg caccgaacgt tcgatggtgc cgatctgggt caccggcatc accccggcca
     8281 ggatcggggt gtcgcagccg gccgccgcga cccggtcgcg cagccgcagg tagtcgtcgg
     8341 cgtcgaagaa catctgggtg atggcgaact ccgcgccggc ccgacactta cgcacgaagt
     8401 gcgcggtgtc gctgtccacg tcggccgagc ggggatgctt gtaggggaag gcggccaccc
     8461 cgacgctgaa gtcgccggcc tcccggacca gccggaccag gtcctcggcg tagtcgacgc
     8521 cctccgggtg ccggatccac tcccctcccg ggtcaccggg cgggtcaccc cggacggcga
     8581 gcacgttgcg cacccccacg ccggccagcc gtccgatcac gttgcgcagc tcggcgacgg
     8641 agtggttgac ggcggtcagg tgcgccatcg gcagcagcgt ggtctcggtg gcgatccgtt
     8701 cggtcaccgc gaccgtggtg tcccgggtcg aaccaccggc cccgtaggtg atcgacacga
     8761 acgacgggcg caacgactcc agctcccgga tggcctgcca gagcagccgc tcgccctgcg
     8821 ccgtcttggg cgggaagaac tcgaacgaga acgtcggctg gcgggcgcgg atcagctccc
     8881 cgatcgccgg ctggggattg ggaaggacag agggaagacc gagcgccacg tgacgactct
     8941 agcgggcgac gcggcccgac cccacgcact tcccaccaga gcatcgacac ccgccgaaac
     9001 ccggccgacc gacgccgtcg ccacgcggcg gcgcacgtcg tgaccccggg gtggaaacgt
     9061 cgtacgccgg gggtagaacg gacgggcgcg ggtggcgtcg gtcggtgccg acgcccgggg
     9121 tcacgcgcgg gggtcggcca ccgtgaccgg cggcatcccg gccgtgctgt ggggcggacg
     9181 ggcacggccg cgtcgacacc caccggagga ccgatgaccc cgtccgaccc gagcctgctc
     9241 gggccgctga tcgcccaact gcggctggcc cgtgggtgga gccagcagcg gctcgccgac
     9301 gagctgtgcg ccaccgccgg cacacccacc ctgacccggc acgaggtgtc ccggtgggaa
     9361 cgggcggtac gggtgccggg cgaccgctgg cgacggcagc tcgccgtcgt cctcgacgct
     9421 ccgatcgggt ccctggccgg cggcccgccc cgcgaccgga aggccgctcc gacccggcgg
     9481 gccgacccga cccggcgggc cgacccgacc cggcgggccg acccgacccg gcgagccact
     9541 cccacccggc agaccgaccc cacccgacct gccactccca cccggcaggc cgctccgacc
     9601 cggcgagcca ctccgacccg gcaggccgct ccgaagccga cccgggccgg caacgccgcc
     9661 ccgggtcgat ggatcgagcc gggtccggac gggccgacac cacagcggcg tcggaccggt
     9721 ccgacgccgg gcaagggacc ggggtcgggc ggcggtcccg tgtcgggcgg cggtcctgtg
     9781 tcgggtggcg gtcctgtgtc gggcggcggt cccgtcttgg gcaagggacc cgtgtcgggt
     9841 ggcggtcccg tgtcgggcaa gggaccgggg tcgggcaacg gtccgtgccg tccggcggga
     9901 caccccggcc gcccggtcgg gcggggtcgg ggtggcgacc gggatgacgc gccgagccgc
     9961 tggtgaggcg gcggcggtgg ggaccggcta gcgtcgtggc gtgacccacg ctgctcccgt
    10021 ctcccctgtc gaccgtgccg gcctgcggca gcgcgtcgac aaggcgttga ccgagttcct
    10081 gtccggccgg cgcagctgga tggccggcat cgacgaggca ctggccccgg tcgccgaggc
    10141 catcgagggg ttcgtgctcg gtggcggcaa gcggctgcgt ccggccttcg cgtactgggg
    10201 gttccggggt gccggcgggg tggacgccga cccggtggtg accgccctgg cggcactgga
    10261 gttcttccag gccagcgcgc tgatccacga cgacctgatg gaccggtcgg acacccggcg
    10321 cggtgagccg gcggtgcacc gacggttcgc cacccgacac cgggcgtccg gctggcacgg
    10381 tgatccggac agcttcggcg acgcggcggc gatcctgctc ggtgacctct gcctggtctg
    10441 gtccgacgag ctgctgcact ccgccggact ggccccgcac acggtggccc gggcccggcc
    10501 ggtcttcgac gagatgcgcg gcgaggtcac cgtcgggcag tacctcgacg tgctcaccca
    10561 ggcgaccggg gaggtctcgc tggagcgggc cggcaaggtg gcccggtaca agtcggccaa
    10621 gtacaccgtc gagcggccgt tgctgctcgg cgccgcgctc gccgacgcgt cgcccgacgt
    10681 gcgtaccgcc tactcggcgt acgggttgcc gctcggtgag gcgttccagc tccgcgacga
    10741 cgtgctggga gtgttcggcg acccggcgca gaccggcaag ccggccgggg acgacctgcg
    10801 cgagggtaag cgcacctacc tggtggcggc ggcggtggag gtcgccgacg aggccggccg
    10861 ggacctgctg ctcagccggc tcggcgatcc ggagctggac gaggacgggg tggcccggct
    10921 ccgcgagctg atcagcgcca ccggcgcgtt ggcccgcacc gagcagcgca tcgtcaccct
    10981 caccgacacc gccctggccg ccctggccgg cgtcgacctc gataccgagg cccgccaggc
    11041 cctggtcgac ctggccatag ccgccacccg ccgcgccgac taaccccctc cccctccccc
    11101 tcccctgcct ccctccccgc cccaccccga ccgcccgacc gcccgcccgc ccaatcacgt
    11161 tgatcaagag gtttcggtca cgaatgggcc ggcggtttct aggcttcagt gcaactgatc
    11221 ttgggttggg ttggaggtcc tggtggcgaa gccgggtgtg ttgacgttcg ggcatcggca
    11281 ggtgttggag catctgtggg cttcgggtcg ga
//
