LOCUS       NZ_JAGFWR010000016     10819 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Micromonospora antibiotica strain MMS20-R2-23 contig16, whole genome
            shotgun sequence.
ACCESSION   NZ_JAGFWR010000016
VERSION     NZ_JAGFWR010000016.1
KEYWORDS    WGS; RefSeq.
SOURCE      Micromonospora antibiotica
  ORGANISM  Micromonospora antibiotica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 138765)
  AUTHORS   Lee,D.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2021) Microbiology & Molecular Biology, Chungnam
            National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, South
            Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 79.63x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017599305.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 02:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,561
            CDSs (total)                      :: 6,498
            Genes (coding)                    :: 6,378
            CDSs (with protein)               :: 6,378
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 20 of 120
            Pseudo Genes (incomplete)         :: 107 of 120
            Pseudo Genes (internal stop)      :: 2 of 120
            Pseudo Genes (multiple problems)  :: 9 of 120
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:14:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8525
            Orig. end                         :: 19344
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAGFWR010000016.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..10819
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..10819
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..10819
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[5000:5819](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5819
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     gene            1105..1353
                     /locus_tag="JQN83_RS22660"
                     /old_locus_tag="JQN83_22660"
     CDS             1105..1353
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287422.1"
                     /locus_tag="JQN83_RS22660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22660"
                     /product="DUF2630 family protein"
                     /protein_id="WP_208569169.1"
                     /transl_table=11
                     /translation="MDDKTILHRISELVDEEHRLRSAAQDHESGTDDEAKEHLRALEES
                     LDQCWDLLRRRRAAREAHGDPEAQGARPVSEVERYLQ"
     gene            complement(1401..2330)
                     /locus_tag="JQN83_RS22665"
                     /old_locus_tag="JQN83_22665"
     CDS             complement(1401..2330)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788255.1"
                     /locus_tag="JQN83_RS22665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22665"
                     /product="serine protein kinase RIO"
                     /protein_id="WP_208569170.1"
                     /transl_table=11
                     /translation="MREHDLPAPQRRGRGRSRFDDDETTFLTYGRQPAGTAPEDEPEPE
                     PEDHWSSWDEAVHGPEPHPPWLVTELAARDTELGVLKTGKEADVHLVRRAVPDTDRSCL
                     LAVKRYRDAQHRLFHRDAGYLEGRRVRRSRENRAMAGRTAFGRQMIAGQWAAAEFAALS
                     RLWEIGAESGRIAVPYPVQLLGTELMLEFVGDPDEGTAAPRLAQVRPDPAPLRSLWEQL
                     VDALVVLARAGYAHGDLSPYNLLVHAGRLVMIDLPQVVDVVANPQGPEFLARDVRVVAT
                     WFTARGLPAADTDPAALTELLLREAGVR"
     gene            complement(2488..3135)
                     /locus_tag="JQN83_RS22670"
                     /old_locus_tag="JQN83_22670"
     CDS             complement(2488..3135)
                     /EC_number="3.1.3.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287424.1"
                     /locus_tag="JQN83_RS22670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22670"
                     /product="HAD family hydrolase"
                     /protein_id="WP_208569171.1"
                     /sec_met_domain="HAD_2 (E-value: 4.3e-13, bitscore: 42.6,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPLLLLDLDNTLLDRAGPFRAWAESFLAEIGAPATDIDWLLSIDA
                     DGLTDRWDIADAIRDRYALRIPSIDLVEELHDGVVGYTRLDPLVACALRIADDAGWLPV
                     VVTNGSVRLEDAKIRQTGLDRYVADWVISEEAGVSKPNPRIFALAAQRARLPLRGAWVV
                     GDSPEADIGGAAAVGLPSVWLHRGRSWTDGRFAPTRTVDSLIAAVSVVLAGG"
     gene            3367..3939
                     /locus_tag="JQN83_RS22675"
                     /old_locus_tag="JQN83_22675"
     CDS             3367..3939
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018788252.1"
                     /locus_tag="JQN83_RS22675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22675"
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_208569172.1"
                     /transl_table=11
                     /translation="MPRVSQDQLDARRQEILGAARACFARHGYEGATVRRLEEATGLSR
                     GAIFHHFRDKDSLFLAVAEDDAAVMVSTVARHGLVQVMRDLLARAVSPDTTGWLGSQLE
                     VSRRLRTDPAFARRWAERSAAIAEATRDRLARQRDAGVLREDIDIDVLAQFLELAYDGL
                     VLHLAMGRPAGDLGPVLDLVEEAVRRH"
     gene            4057..5004
                     /locus_tag="JQN83_RS22680"
                     /old_locus_tag="JQN83_22680"
     CDS             4057..5004
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018583042.1"
                     /locus_tag="JQN83_RS22680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22680"
                     /product="TIGR04222 domain-containing membrane protein"
                     /protein_id="WP_208569173.1"
                     /transl_table=11
                     /translation="MNTLAAQGDTWGIPGPLFLKLYLLVAVVAVVGTLLHRRRTTAGPD
                     TVTTDQLGPQQVAYLNGGDQLAIWAALGGLRGAGAIDVTSNGRLVAVGSTPSGLTPLDH
                     AIRHAARQSVATRELRRNGGVTRALEELRQGLEQRGLLIDADGVRALRRGRNLLLVLLA
                     LGVVRLVAGLFNGRPVGWLLLALAGLAVAFALVARTPRRTRTANVMMSRLRSSNHHLAP
                     DAAPAYATYGPAGAAMGVALFGTVSLYALDPGFAAQAEIQRQALNASSGSGYTGSTGVT
                     CGGSTSSGDSGSSCGGGSSCGGGGGCGGGGGCGG"
     gene            5001..5819
                     /locus_tag="JQN83_RS22685"
                     /old_locus_tag="JQN83_22685"
     CDS             5001..5819
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: DUF692"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018802926.1"
                     /locus_tag="JQN83_RS22685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22685"
                     /product="DUF692 domain-containing protein"
                     /protein_id="WP_208569174.1"
                     /sec_met_domain="DUF692 (E-value: 4.4e-81, bitscore: 264.9,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGPQGVGIGWRSEIAGFVAELPGLRFVEVVAESLSPGNPLPAGL
                     AGLRERGVTVVPHGVRLSLGGADPVDPARVTHLARVAELVDAPLVSEHIAFVRAGGLEA
                     GHLLPLPRTREAVAAVVANVRRARAELPVPLALEPIAALFDWPDDELDEADFLTEILDA
                     TDAELLLDVANVYANARNRGEDPHALLDRLPLDRIAYVHVAGGAEYGGLYHDTHTDPVP
                     TEVLELVGALCAGRRPPALLLERDGHYPPADVLRAELDALATAAGHPVVT"
     gene            5816..6301
                     /locus_tag="JQN83_RS22690"
                     /old_locus_tag="JQN83_22690"
     CDS             5816..6301
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018223393.1"
                     /locus_tag="JQN83_RS22690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22690"
                     /product="hypothetical protein"
                     /protein_id="WP_208569175.1"
                     /transl_table=11
                     /translation="MSPTHPVESAPPPGPVGLAARQAALVAALVAGAPLPAGFATDRVD
                     AARRALLRKRAGEVARHWPLLAAGLGDTWPATFTDWASGRPTVGSLRDGWDLARGLRDR
                     DALPPLGAQELAAREATHRYDGRHPPRRRRLPALARSGDAVALQVAGRVRLLRPARR"
     gene            6364..7116
                     /locus_tag="JQN83_RS22695"
                     /old_locus_tag="JQN83_22695"
     CDS             6364..7116
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018815297.1"
                     /locus_tag="JQN83_RS22695"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22695"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_208569176.1"
                     /transl_table=11
                     /translation="MDLGLTDRVYVLTGASRGLGFATAQCLVADGARVVLSARTPERVA
                     GAVDRLGGPDHAIGLVADLADPSLPERLVIAAGEHFGRLDGALVSVGGPPPGTAAQVSD
                     AQWRESFETVFLGTVRTARTVAAALTDGGAIGMVLSTSARTPITGLGISNGLRPGLAGV
                     AKDLSDEYGPRGVRVLGLLPGRFLTDRNRELLGDDAAARAAAEAGIPLRRIGDPAEFGR
                     VAAFLLSPAAGYVTGVSVPVDGGALRSL"
     gene            7299..7955
                     /gene="mug"
                     /locus_tag="JQN83_RS22700"
                     /old_locus_tag="JQN83_22700"
     CDS             7299..7955
                     /EC_number="3.2.2.28"
                     /GO_function="GO:0000700 - mismatch base pair DNA
                     N-glycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006285 - base-excision repair, AP site
                     formation [Evidence IEA]"
                     /codon_start=1
                     /gene="mug"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013287431.1"
                     /locus_tag="JQN83_RS22700"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_22700"
                     /product="G/U mismatch-specific DNA glycosylase"
                     /protein_id="WP_208569177.1"
                     /transl_table=11
                     /translation="MSDPVGPSAGPTRAGVAQVRRPDRAGTPQVRRPDRAELAAAADRT
                     IPDVIGPGLTVLFVGINPGLWSAATGWHFARPGNRFWPALHRGGFTPRRLHPSEQDTLP
                     GYGLGITNMVARASARADELTPAELVAGARTLTDKVARYRPTWVAVVGVTAYRIGFARP
                     KAGFGPQPHPLAGARLWVLPNPSGLNAHFTPQTLGAAFGELRAVIAGHPPADRSA"
     misc_feature    complement(8162..8177)
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: medium, score: 24.54"
                     /tool="antismash"
     misc_feature    8163..8176
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 18.46"
                     /tool="antismash"
     misc_feature    complement(8179..8196)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 17.31"
                     /tool="antismash"
     misc_feature    complement(8211..8228)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.23"
                     /tool="antismash"
     gene            8255..8692
                     /locus_tag="JQN83_RS22705"
                     /old_locus_tag="JQN83_22705"
     CDS             8255..8692
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQN83_RS22705"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQN83_22705"
                     /product="hypothetical protein"
                     /protein_id="WP_208569178.1"
                     /transl_table=11
                     /translation="MPQVRSSRSIRLLAAGAAGAAAVAMFPAVSAQAGTSSINVSVKGG
                     YNNTQSLGTATGTVTGTTGSTQASYSVTLCGQSTYPSASVTIQGGTATATHTVYYQNCE
                     TFTGDLVSSYGFTNVQVSVSGSTFYPGSQYTTYTKTKAVYF"
     misc_feature    complement(9178..9192)
                     /note="TFBS match to MexT, Global virulence regulator,
                     confidence: weak, score: 15.76"
                     /tool="antismash"
     misc_feature    9444..9458
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.46"
                     /tool="antismash"
     misc_feature    9767..9782
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.45"
                     /tool="antismash"
     misc_feature    complement(10319..10332)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 18.11"
                     /tool="antismash"
     misc_feature    10474..10485
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.46"
                     /tool="antismash"
ORIGIN
        1 ccactcctgc tcggtcagcg gcagggtggt gcccgaccgg gcctgctgga tcacccggtc
       61 ctccagcagc cggaaccggg ccaccgcgtc cgagccggcg agctggtcgt agcggacccg
      121 gtcggccggg gacagctcgg cgaccgcctc cgccgtctgg tagcgctggg cgccgaccag
      181 ttgggtgaag cgggcgtact cttcgccggt catccggccg gccgcgagca cgccggtgat
      241 cagggcatcc tgttgggaga tcagctcccg cacctggtag aggtcgacca gggtctcgct
      301 ctccgcggcg atccgcgtgt cgtcgagctg ccccagcgag ccgtacatcc gcagcacccc
      361 ggcgaggacc ccggtgtacg cggcggacgc ctcggcccgg gtcatcccgg cgtcgcgcac
      421 cgactcccgg atgccggtca ggccactcag gccggtcagc acctcgtcga cccggcggcg
      481 ggtgtcctcg ccggtggcca gctcggcctg ccaactgccc accgaggtgc cgaactcgtc
      541 cgccacctgg tcggtgcgct gccactgggt gctcaacgcg tcgagttgcc gctgggcccg
      601 ctcacccagg taggcgttgg cgagccgccg ctcctcctgg agcgcggtga gcagcgactc
      661 cccggggtcg gccacccggc tgttgagggt ctgcacccag agcaggttga agccgtcacc
      721 gacggtcacc caggcggcga aggaccagag cgcgacgagg gaggtgagca gggccacgat
      781 cttggtacgc agacgcgtgc tgccggaacc catcacaccg cccccgggcc ggaccgtggc
      841 caccggacgc ccgacgcgtc acggcacacc tgaacccggc gcacgctagc agtcggcacc
      901 accatcgctc aagccatgct gatcatggag gcggggccgg tgccgcaggt cctggggcga
      961 tggtgaccac cgtggatggt gccggcaccc catgaggcag ccgacccggc gaccacccgg
     1021 cgcgggccac ggccgcctgg ccgccggcgg accggccggc cccgaacacg ggcgcgggcg
     1081 atcctgctgt gccaggctca tggcatggac gacaagacca tcctgcaccg gatctcggaa
     1141 ctggtcgacg aggagcaccg gctccgctcg gccgcccagg accacgaatc cggcaccgac
     1201 gacgaggcca aggaacacct gcgcgcgctg gaggagtcgc tggaccagtg ctgggacctg
     1261 ctgcgccgcc gccgggcggc ccgggaggcg cacggcgacc cggaggccca gggggcccga
     1321 ccggtgtcgg aggtcgagcg ttacctccag tgacgccccg acgtcccgga cggccggttg
     1381 ccgtccggga cgtcacccgt tcagcgcacc cccgcctcgc gcagcagcag ctcggtgagg
     1441 gcggccgggt cggtgtcggc ggcgggcagc ccccgggcgg tgaaccaggt cgccaccacc
     1501 cgcacgtcgc gggccaggaa ctccggtccc tgcgggttgg ccaccacgtc gaccacctgc
     1561 ggcaggtcga tcatgacgag ccgcccggcg tgcaccagca ggttgtacgg cgacaggtcg
     1621 ccgtgggcgt agccggcccg ggccagcacc accagggcgt ccaccagttg ctcccagagg
     1681 gagcgcagcg gggccgggtc ggggcgtacc tgggccagcc ggggtgcggc ggtcccctcg
     1741 tcggggtcgc cgacgaactc cagcatcagc tcggtgccga gcagctgcac cgggtacggc
     1801 acggcgatcc gcccggattc cgcaccgatc tcccagagcc gggacagcgc ggcgaactcg
     1861 gccgccgccc actgcccggc gatcatctgc cggccgaacg ccgtccggcc ggccatcgcc
     1921 cggttctccc gggaccggcg cacccggcgt ccctccaggt agccggcgtc gcggtggaag
     1981 agccggtgct gggcgtcgcg gtaccgcttg acggccagca ggcaggaccg gtcggtgtcg
     2041 ggcaccgccc ggcggacgag gtgcacgtcc gcctccttgc cggtcttgag cacaccgagt
     2101 tcggtgtccc gggcggccag ctcggtgacc agccacggcg ggtgcggttc gggaccgtgc
     2161 acggcctcgt cccaggagga ccagtggtcc tcgggctcgg gctcgggttc gtcctcgggt
     2221 gcggtgccgg ccggctgccg gccgtacgtc aggaaggttg tctcgtcgtc gtcgaagcgg
     2281 cttctgccgc ggccacggcg ctgcggcgcc gggaggtcgt gttcgcgcac ggtgctggtg
     2341 atcccttggt cgaggctggt gagggcaggt ggtacgaccc tgcaaagacg gccatgaccg
     2401 acctcctctc ctcgaccggg ccccgcccgg ctgcgcgctc ccgcgcgggc ccatgctgac
     2461 cgataccccg cccggcgcac aaccggatta ccccccggcg agcaccaccg agaccgccgc
     2521 gatcaacgag tcgacggtac gggtgggggc gaaccgcccg tcggtccagc tgcgcccccg
     2581 gtgcagccag acgctgggca ggccgaccgc ggcggccccg ccgatgtccg cctccgggct
     2641 gtcgcccacc acccacgcgc cgcgcagcgg caaccgggcc cgttgggcgg ccagcgcgaa
     2701 gatccggggg ttgggcttgc tcaccccggc ttcctcggag atcacccagt cggcgacgta
     2761 gcggtcgagg ccggtctgcc tgatcttggc gtcttccagc cggaccgagc cgttggtgac
     2821 caccaccggc agccacccgg cgtcgtcggc gatccgcagc gcgcaggcga ccagcgggtc
     2881 cagccgggtg tagccgacca ccccgtcgtg cagctcctcg accaggtcga tggaggggat
     2941 gcgcagcgcg tagcggtccc ggatggcgtc ggcgatgtcc caccggtcgg tgaggccgtc
     3001 ggcgtcgatg gacagcagcc agtcgatgtc ggtggccggg gcgccgatct cggccaggaa
     3061 actctcggcc caggcgcgga acggcccggc ccggtcgagc agggtgttgt ccaggtcgag
     3121 caggagcaac ggcactgagg caccttacgg gaggaaggac cgccgccgac agggtcgaac
     3181 cgcccgccgg cgaccgtcgg gctgccgggg ccggatgggg gcggtgggcg ggtaggggga
     3241 ggtgaccggg gctgtcggca ccggccgatc ctaaccggac gggcgttcgg caggacgagg
     3301 tgacgacccg atagcaagcc gtacgtacgg tttgccttgc ggagggtcac ctgcgacgat
     3361 cgacccgtgc ccagagtaag tcaggaccag ctcgacgcgc gccggcagga gatcctgggc
     3421 gcggcccggg cctgtttcgc ccggcacggc tacgagggtg ccaccgtgcg ccggctggag
     3481 gaggcgaccg gcttgtcccg gggcgcgatc ttccaccact tccgcgacaa ggactcactc
     3541 ttcctcgccg tcgccgagga cgacgccgcc gtgatggtct ccacggtggc ccgccacggc
     3601 ctcgtccagg tgatgcggga cctgctcgcc cgcgcggtct cccccgacac caccggctgg
     3661 ctgggcagcc aactggaggt gtcccggcgg ctgcggaccg acccggcctt cgcccgccgg
     3721 tgggcggaac gctccgccgc catcgccgag gcgacccggg accggctcgc ccggcaacgc
     3781 gacgccgggg tgctccgcga ggacatcgac atcgacgtgc tggcccagtt cctggagctg
     3841 gcgtacgacg ggctggtgct gcacctggcg atgggccggc ccgccggtga cctggggccg
     3901 gtgctcgacc tggtcgagga ggccgtccgc cggcactgac ccacccgggc cggcagcccg
     3961 gatctcggct cggtaactcg cccaccgccc cggtgccggc gtggcggggc tgctccacaa
     4021 tgaggccgcg accccctcgc gcgacaggag cagctcatga acacgcttgc cgcacagggc
     4081 gacacctggg gcatccccgg gccgctcttc ctgaagctct acctgctggt ggccgtcgtc
     4141 gccgtggtcg gcacgctgct gcaccgccgc cgcacgaccg ccggccccga cacggtcacc
     4201 acggaccagc tcggacccca gcaggtggcc tacctcaacg gtggcgacca gctcgccatc
     4261 tgggcggcgc tgggtgggct acgcggcgcc ggcgcgatcg acgtcacatc gaacggccgg
     4321 ttggtcgccg tcgggtcgac acccagcggg ctcactccgc tcgaccacgc gatccggcac
     4381 gccgcccgcc agtcggtcgc cacccgcgag ctgcgccgca acggcggggt gacccgcgcc
     4441 ctggaggagc tgcggcaggg gttggagcag cgcggcctgc tgatcgacgc cgacggggta
     4501 cgggccctgc ggcgcggacg gaacctgctg ctggtgctcc tggccctggg tgtggtgcgg
     4561 ctggtcgccg gcctgttcaa cggccggccg gtcggctggc tactgctcgc cctggccgga
     4621 ctcgccgtgg cgttcgccct ggtggcccgt acgccccggc ggaccaggac ggcgaacgtg
     4681 atgatgagtc gcctgcgcag cagcaaccac cacctcgccc ccgacgccgc cccggcctac
     4741 gcgacctacg gtccggccgg cgcggcgatg ggggtggccc tgttcggcac cgtctccctc
     4801 tacgcgctcg accccggctt cgccgcgcag gcggagatcc agcggcaggc gttgaacgcc
     4861 agcagcggca gcggctacac cggttccacg ggtgtcacgt gcggcggcag cacctcgtcg
     4921 ggcgacagcg gctcgtcgtg cggtggcggc agctcctgcg gcggcggagg aggatgcggc
     4981 ggcgggggcg ggtgcggcgg atgaccgggc cgcagggggt gggcatcggc tggcggtcgg
     5041 agatcgccgg tttcgtcgcc gagctgcccg ggctgcgctt cgtcgaggtg gtagcggagt
     5101 cgctcagccc gggcaacccc ctgccggccg ggctggccgg gctgcgggag cgcggcgtga
     5161 ccgtcgtacc gcacggggtg cggctctccc tcggcggcgc ggacccggtc gacccggccc
     5221 gggtgacgca cctggcccgg gtggccgagc tggtcgacgc gccactggtc agcgagcaca
     5281 tcgcgttcgt ccgggccggc ggcctggagg ccgggcacct gttgccgttg ccgcgcaccc
     5341 gggaggcggt ggcggcggtg gtggcgaacg tccgccgggc ccgggcggag ctgccggtgc
     5401 ccctggcgtt ggagccgatc gccgcgctgt tcgactggcc cgacgacgag ctggacgagg
     5461 cggacttcct caccgagatc ctcgacgcca ccgacgcgga gctgctgctc gacgtggcaa
     5521 acgtgtacgc caacgcccgc aaccggggcg aggacccgca tgccctgctg gaccggctgc
     5581 cgctggaccg gatcgcctac gtacacgtgg ccggtggggc cgagtacggc gggctctacc
     5641 acgacacgca caccgatccg gtgcccaccg aggtgttgga gctggtcggc gcgctctgtg
     5701 ccggccgccg accgccggcc ctgctgctcg aacgcgacgg ccactaccca cccgccgacg
     5761 tgctgcgggc cgagttggac gccctcgcca ccgctgccgg ccacccggtc gtcacatgag
     5821 cccgacgcac cccgtcgagt cggccccgcc gcccggaccg gtggggctgg ccgcccgaca
     5881 ggccgcgctg gtcgccgccc tggtcgcggg ggccccgctg ccggcaggct tcgccaccga
     5941 ccgggtcgac gccgcccggc gggcgctgct gcgcaagcgg gccggcgagg tcgcccgcca
     6001 ctggccgctg ctcgccgccg gcctcgggga cacctggccg gccaccttca ccgactgggc
     6061 gtccggccga cccaccgtcg ggtcgctgcg cgacggttgg gacctcgcac gtgggctgcg
     6121 cgaccgggac gccctccccc cgctcggcgc gcaggagctg gccgcccgcg aggccaccca
     6181 ccgctacgac gggcggcacc cgccccgccg ccgccggttg ccggccctgg cccgcagcgg
     6241 cgacgccgtc gccctccagg tcgccggccg ggtacgcctg ctgcgaccgg cccgccgctg
     6301 accaccgggt cgcctccccg gcccgccgcg ccacccaccg ccggatgcgg caggatcggt
     6361 ggcatggatc tcggactcac cgatcgggtg tacgtgttga ccggcgcttc ccgggggctc
     6421 ggcttcgcga ccgcacagtg cctggtcgcg gacggggcac gggtggtcct gtcggcccgc
     6481 acgccggagc gggtcgccgg ggcggtcgac cggctcggtg ggccggacca cgcgatcggt
     6541 ctcgtcgccg acctggccga cccgagcctg cccgagcggc tggtgatcgc cgccggagaa
     6601 cacttcggcc gcctcgacgg ggcgctcgtc tcggtcggtg ggccgccccc gggcaccgcc
     6661 gcgcaggtca gcgacgcaca gtggcgggag tccttcgaga cggtcttcct gggcaccgtc
     6721 cggacggccc ggacggtggc cgccgcgctc accgacggtg gcgcgatcgg tatggtgctg
     6781 tccacctcgg cccggacgcc gatcaccggc ctcggcatct ccaacggcct gcggcccggc
     6841 ctggccggcg tggccaagga cctgtccgac gagtacggcc cacgcggggt gcgggtgctg
     6901 ggcctgctgc ccgggcgctt cctgaccgac cgcaaccggg aactgctcgg cgacgacgcg
     6961 gcggcccgtg ccgctgcgga ggccggcatt ccgctgcgcc gcatcggcga tccggccgag
     7021 ttcgggcggg tggcggcctt cctgctctcc cccgccgccg gctatgtcac cggggtcagc
     7081 gtgcccgtcg acggcggcgc gctgcgcagc ctgtgacccc gcgacgccgc tcgaccagcc
     7141 ccgccgccgc ccccgaaccg gccccggccg ccgaaccggg ccgcaccgcc ccagaaccgc
     7201 ctcccgccgt cgcggcctcc gaaccggccc gtcgtcgggg caccggcggg cggccctccc
     7261 cggcccctgc cgagcgcccg tccacgaccg tcgacgcgat gtccgacccg gtcgggccct
     7321 ccgccggccc gacccgggcg ggcgtggcgc aggtacggcg accggaccgg gcgggcacgc
     7381 cgcaggtacg gcggccggac cgggcggagc tggcagcggc ggcggaccgc accatcccgg
     7441 acgtgatcgg ccccgggttg acggtgctct tcgtcgggat caacccgggc ctgtggtcgg
     7501 cggccaccgg gtggcacttc gcccggccgg gcaaccggtt ctggccggcc ctgcaccggg
     7561 gcggcttcac cccgcgccga ctgcacccga gcgagcagga caccctgccc gggtacggcc
     7621 tgggcatcac caacatggtg gcgcgggcca gcgcccgggc ggacgaactg actccggcgg
     7681 agctggtggc gggcgcgcgg acgctgaccg acaaggtggc ccggtaccgg ccgacctggg
     7741 tcgccgtggt cggggtgacc gcctaccgga tcgggttcgc ccggccgaag gccggtttcg
     7801 gcccgcagcc gcacccgctg gccggcgcgc ggctctgggt gctgcccaac cccagcggcc
     7861 tgaacgccca cttcaccccg cagaccctgg gggccgcctt cggcgagctg cgcgccgtca
     7921 tcgccggcca cccgccggct gaccggtcgg cgtgaccacc ctgacgagat gaacccttcc
     7981 cgtaccgcgt gaacaccgcc gcgaaccacc gggacggctg gccgggaacg gccagccgtc
     8041 cactccgcgt gccggctcac gctgtccgtg gggtggcgcg ttcacgatgt gtcgggtaaa
     8101 gggtgaaatt gaggcaataa attgctcccc cgactcacca ccctattgac gaagatttat
     8161 ttcgaacgtg ctttcgactt caccttggtc taacattggg cccgcaatcg gttacacgtc
     8221 gttaacgcaa ttctccagca gatcaggagc agttatgcct caagtccgtt cttcccgctc
     8281 catccgcctg ctcgccgcag gcgccgccgg ggcggccgcg gtggccatgt tccccgcggt
     8341 cagcgcccag gcgggcacgt catcgatcaa cgtctcggtc aagggtggct acaacaacac
     8401 ccagtccctc ggcaccgcca ccgggaccgt caccgggacg acgggcagca cccaggcaag
     8461 ctactcggtg acactgtgcg ggcagagcac ctacccgagc gccagcgtca ccatccaggg
     8521 cggaaccgcc acggccaccc acaccgtcta ctaccagaac tgcgagacct tcaccggcga
     8581 tctcgtctcc agttacggat tcaccaacgt ccaggtcagt gtgtccggtt ccaccttcta
     8641 cccgggcagc cagtacacca cgtacacgaa gaccaaagcg gtgtacttct gagttaccgt
     8701 cgcacctgat gacggaacag gcaccgaatt gacgatcgcc gcctcgggca gccgccgcgc
     8761 cggcagcccg tgagtcgtgc cgacggccgg tgggacgtgt cgtcggcacc cggcgtgggg
     8821 agcgccgtcg gaatgcgaga ccaggccagg gcccgctccc cctggcctga cctcgtttca
     8881 ctggcggcag caggcagccg aggtgtgccc cgaacccggt ccgcagaaca cgagtcgggt
     8941 cagcacggtg gtcgcttccg ggacggggtc ccgtcagttg gccacggccg ggggcagcgc
     9001 ctcctgcgcg acgtaggtgc ccatcggcac ggtggtgatg atcggctcgg gctggtccgc
     9061 ctcggcgtac ggggcaggcg agtcgacgac ggcgaactgg gtgcggtaca gctcggcgta
     9121 gagcccaccg accgcgacca gttcctcgtg gcggccccgc tccacgatcc ggccaccatc
     9181 gaggaccagg atctggtcgg cgtcacggac ggtggagagt cggtgcgcga tcaccagcgc
     9241 ggtacgcccg gccaacgcca cggacagggc ccgctgcacc gccgcctcac tctccgagtc
     9301 gagatgggcg gtggcctcgt ccaggatcac gatcgacggg gccttgagca ggagccgggc
     9361 gatggcgatg cgttgcttct cgccgccgga gaagcggtag ccgcgctcgc cgacggtcgt
     9421 ctccagcccg tcgggcaggg cgcggaccag gtcggccacc tgcgcaccgg ccagcgccgc
     9481 ccagatctcg tcgtccgtgg cgtccggctt ggcgtaccgc aggttctcgg cgatcgtctc
     9541 gtggaacagg tgggagtcct gggtgaccac accgatctcg tcgcgcagcg aggcgagggt
     9601 ggcgtcccgg acgtcgaccc cgccgacccg caccgcgccg tcggtgacgt cgtagatccg
     9661 tgagatcagc atggacagcg tggacttgcc ggccccggac ggcccgacca gcgccaccat
     9721 ctgccccggc tcgacgcgga acgagacgcc cttgagcacc ggctcgttgg ccgtccggtc
     9781 gagggtggcg acctcctcca gcgaagccaa cgagacgtcg gcggcagccg ggtagcggaa
     9841 ccggacatcg cggaactcga cccggccggc gccccggggg accggcaccg cgtcgggctt
     9901 ctcctcgatg ccggggcgca ggtcgagcac ctcgaagacc cggtcgaagg agaccagggc
     9961 gctcatcacg tcgacccgga cgttggacag cgcggtcagc ggaccgtaga ggcgggtgag
    10021 cagcagggcg agggtgacca cggtgcccgc gctgaccgcc ccggtgaccg ccagccagcc
    10081 gccgagcccg taggtgagcg cctgggccag cgacgcgacc agcagcatcg ccacgaagaa
    10141 ggtgcgtgag tacatcgccg actggatgcc gatgtcgcgg acccgttcgg cccgcgcggc
    10201 gaatcggccc gcctccacct caggcgtgcc gaacagcttg accagcagcg cgcccgccac
    10261 cccgaaccgc tcggtcatgg tggcgttcat cttggcgtcg aggtcgtacg actcccgggt
    10321 gatctcggcc aaccgccggc cgacccgccg cgccggcacc acgaagatcg gcaacaggac
    10381 cagcgacagc agggtgatct gccaggagag ggtgaacatc accccggcgg tgagcaccag
    10441 ctggatgacg ttgctgacca cccccgacag ggtggaggtg aacgcccgct gggcgcccat
    10501 cacgtcgttg ttgagccggc tgaccaacgc accggtctgg gtccgggtga agaactgcaa
    10561 cggcatccgc tgcacgtggt cgtagacccg ggtgcgcagg tcgaggatga tgccctcgcc
    10621 gatacgcgcc gaataccacc gctggaccag ggagaacagc gcgtcggcga cggccagcgc
    10681 gccgatgatc agggcgagcc ggacgacgac cgcacccgcc tcggggccac ccccgctgat
    10741 cgcgttgatc acgtggccgg ccagcaccgg ggtggccacc ccgatcacgg cggcgatgac
    10801 cacggtcacc aggaagacg
//
