LOCUS       NZ_JAGFWR010000005     11935 bp    DNA     linear   CON 29-AUG-2024
DEFINITION  Micromonospora antibiotica strain MMS20-R2-23 contig5, whole genome
            shotgun sequence.
ACCESSION   NZ_JAGFWR010000005
VERSION     NZ_JAGFWR010000005.1
KEYWORDS    WGS; RefSeq.
SOURCE      Micromonospora antibiotica
  ORGANISM  Micromonospora antibiotica
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Micromonospora.
REFERENCE   1  (bases 1 to 373542)
  AUTHORS   Lee,D.-H.
  TITLE     Direct Submission
  JOURNAL   Submitted (22-MAR-2021) Microbiology & Molecular Biology, Chungnam
            National University, 99, Daehak-ro, Yuseong-gu, Daejeon 34134, South
            Korea
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Method                   :: SPAdes v. 3.13.0
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 79.63x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017599305.1-RS_2024_08_29
            Annotation Date                   :: 08/29/2024 02:05:54
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.8
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,561
            CDSs (total)                      :: 6,498
            Genes (coding)                    :: 6,378
            CDSs (with protein)               :: 6,378
            Genes (RNA)                       :: 63
            rRNAs                             :: 4, 1, 1 (5S, 16S, 23S)
            complete rRNAs                    :: 3, 1, 1 (5S, 16S, 23S)
            partial rRNAs                     :: 1 (5S)
            tRNAs                             :: 54
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 120
            CDSs (without protein)            :: 120
            Pseudo Genes (ambiguous residues) :: 0 of 120
            Pseudo Genes (frameshifted)       :: 20 of 120
            Pseudo Genes (incomplete)         :: 107 of 120
            Pseudo Genes (internal stop)      :: 2 of 120
            Pseudo Genes (multiple problems)  :: 9 of 120
            CRISPR Arrays                     :: 8
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-12 22:14:58
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 237762
            Orig. end                         :: 249697
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAGFWR010000005.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..11935
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193 or (YcaO or TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..11935
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..11935
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[5000:6935](+)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..6935
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193 or (YcaO or
                     TIGR03604))"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     misc_feature    complement(16..29)
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 21.65"
                     /tool="antismash"
     misc_feature    726..739
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: medium, score: 21.28"
                     /tool="antismash"
     misc_feature    881..896
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.91"
                     /tool="antismash"
     misc_feature    complement(1289..1298)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 14.29"
                     /tool="antismash"
     misc_feature    complement(1372..1386)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 15.83"
                     /tool="antismash"
     misc_feature    1436..1449
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 14.39"
                     /tool="antismash"
     misc_feature    complement(1561..1574)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.01"
                     /tool="antismash"
     misc_feature    1561..1575
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.0"
                     /tool="antismash"
     gene            1599..2933
                     /locus_tag="JQN83_RS12870"
                     /old_locus_tag="JQN83_12870"
     CDS             1599..2933
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1020: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF017760.5"
                     /locus_tag="JQN83_RS12870"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_12870"
                     /product="MFS transporter"
                     /protein_id="WP_208567345.1"
                     /transl_table=11
                     /translation="MTAAPSQETKPANSPHRGRDFRLYWIAGAIDQLGSQASGIVLPLV
                     TLAVTGSPAAAGLVGALALAGRLVAAPVAGVLADRLPRKRMMVSSLLVAAAAMSTIFFV
                     LVADVATLGLLAAAAFVEGIAQSGYEAAGSGAIRRLLPADDQKALSRLEARNHAARLTG
                     PLLGGVLYQLARWLPFLADVLSYLLAAALVATIRTDLTPERAERTSFRTDLRVGLRFVW
                     RQPFLRFVTIWAAGINFTFGALVYYAILTAGRQGAPAASIGLILTIASVGGLSGALAAP
                     MIFSRVRPTTVIVFASWAMVGLVVAMSQARQTWSYGLLFGLVFLLSPLLGVIFQSRVIA
                     LTPDELQGRVATVMGTVGEALQTPAPLLAGVLVAWYSPGTVALVFAAALALLATYTTVS
                     LRQLRAGAGATAGTDPGPTDGTGPTDGTDPGPAAGAAPDPEEARR"
     gene            2930..4747
                     /locus_tag="JQN83_RS12875"
                     /old_locus_tag="JQN83_12875"
     CDS             2930..4747
                     /EC_number="3.4.-.-"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012546.5"
                     /locus_tag="JQN83_RS12875"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_12875"
                     /product="S9 family peptidase"
                     /protein_id="WP_208567346.1"
                     /sec_met_domain="Peptidase_S9 (E-value: 3.1e-33, bitscore:
                     109.3, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRGHRLFYPALPVVAEHAPHRAVYVGDAGGRCEILTWDRLAGTA
                     RQVTDRAAGTIRAALDPTGSTIWWFDDDLGGVGTWRTCDFDQPDRSVAALPSVPPARHA
                     GIAMATDGTTAIGLSDDGGMTLFLRTGDGRVSERTHVTGYAYLVDLDPAGRLAVIGADA
                     ATDAAVTVVTTDGVRVAGIAGCADGRVWALGFAPGSGPARLLLVIEDEGGYLPATWTEE
                     EGLVRHDWCRFDTEVTAGWFPDGRRLLVRQDRHARSLLHEVDLAGRTRAVVDTPTGSIL
                     DAAVWPDGDVAYVWTDSVTPPQLRSVRGVQLPEHPGGQPDVGGPDPVATPVEHRREEIR
                     VPGPGGPIPALVALPADRQGPRPAVFLVHGGPFQHARDAYDPLVEILVSTGCAVVRVNY
                     RGSSGYGATWRNDFSAGVGLTQLADLAAVRAHLVAAGVVEDRRTALWGTSWGGYLTLLA
                     LGRQPELWRLGIAISPVADYVAAFEAATPAVRALDVLLFGGTPDEVPQRYARSSPITYV
                     DQVRAPVLLAVSTGDVRCPPAPVEHYARLLAERRIPHQVVRRRAGHEDFDAQSHLALMQ
                     TVLLFMQRHFDGVRDEGTPVALAMARPAG"
     gene            5001..6935
                     /locus_tag="JQN83_RS12880"
                     /old_locus_tag="JQN83_12880"
     CDS             5001..6935
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR03975"
                     /gene_functions="other (smcogs) SMCOG1277: Radical SAM
                     domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007076102.1"
                     /locus_tag="JQN83_RS12880"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_12880"
                     /product="RiPP maturation radical SAM C-methyltransferase"
                     /protein_id="WP_372444020.1"
                     /sec_met_domain="TIGR03975 (E-value: 1.5e-181, bitscore:
                     599.1, seeds: 14, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLVNMPWTSIDVPSLAIGILTNSVRQKMPDAEVEAVHANLDFVDW
                     VVDRTEFGLSDYYYYSLFTYFAGCGDWVFSSALYDDPQWRVQEFTDRVRTQMTERELAL
                     NLELHRLAPEFVAELADRIVAQAPDVVGFTSTFQQNAAALATARAIKKRSPGIRTVMGG
                     ANCDGEQGAAIHRNFSFVDFVVRGEGETAFPRLLAALDPARSAAVGAEPAGGLADIEGL
                     CWGGPDGRSVANPMSTTPLPPAEIVAPDYAGYFERLAASRAQHWVEPRLVVEGARGCWW
                     GEKHHCTFCGLNGSFMQFRSKHPGRFYDEIIELVERHQVLDMFVVDNILDMSYVTSLLP
                     RLTESDYDLRLQYEIKSNMKGPQVQALADAGLVSVQPGIESLNSRVLKLMDKGVSGCLN
                     IRMLRDAETSGITIAWNYLYGFPGETEDDYLPVIAQMPALHHLCPADGSTRIAIERFSP
                     FFVRPELGFTDLRPAAQYRLIYDLPESELMDLAYLFDVPPQGIGGETADRLDRAVTEWQ
                     HEYARSRLTHHDLGDEIVLVSRRRHFDWHVLRLTDPVEVAVFRQLDQPHSVSALARRLS
                     VDEPVLTALLRRWRGLGLVYEDAGQFIQIAPQAMNQDLLRIDHLHLEREAAETRAAAEA
                     GEPAALSAV"
     gene            6947..7630
                     /locus_tag="JQN83_RS12885"
                     /old_locus_tag="JQN83_12885"
     CDS             6947..7630
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039872.4"
                     /locus_tag="JQN83_RS12885"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_12885"
                     /product="DUF5825 family protein"
                     /protein_id="WP_208567348.1"
                     /transl_table=11
                     /translation="MSTIDAGLRPILVGLARDHDPAVLSIPGMTIGPAELREPAADAVA
                     RWRSAGVRRVDLPDVVDLTVTGDDATAVDTVRRLVLVRELTSHGIAVDWRLRLPGVEAD
                     EWLPYSHLRAPVELLPAPGGEGDPVAQLDAWVKGFYFDKCTYRRGPGFVQVRDRRAGRL
                     NLLTIDDPAYLAVLDQLLDGAAVTGVDLSIARDFGAEGLVTKIGELLVWLPHRLRRWPL
                     PSMVI"
     misc_feature    complement(7874..7888)
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 16.51"
                     /tool="antismash"
     gene            8111..9142
                     /locus_tag="JQN83_RS12890"
                     /old_locus_tag="JQN83_12890"
     CDS             8111..9142
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013286852.1"
                     /locus_tag="JQN83_RS12890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_12890"
                     /product="glycoside hydrolase family 11 protein"
                     /protein_id="WP_208567349.1"
                     /transl_table=11
                     /translation="MSDTSTRPRRSGRLRLLLSAACAAALAVTGTFIASPNAYAENDRT
                     LTSNLTGTHNGYFFSFWKDSGNASMTLRADGRYSSSWDRSTNNWVGGKGWATGTRRTVS
                     YSGSYNPGNNNTYLALYGWTRNPLIEYYVVENFGSYNPSSGATRMGTVTTDGGTYDILR
                     SLRVNAPSIDGNQTFYQYWSVRQQKRSSGTITTANHFDAWARAGLNLGTNHSYQIMATE
                     GYQSQGSSDITVREGGGSNPTSGPTGNPTTPPAGGNCTAVLSAAEQWGDRFNLNVAVSG
                     TSNWVVSLGLNGGQSIQNSWNASVSGTTGTVTARPNGNGNNFGITIMANGNWTWPTVSC
                     RTA"
     gene            complement(9227..11668)
                     /locus_tag="JQN83_RS12895"
                     /old_locus_tag="JQN83_12895"
     CDS             complement(9227..11668)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007455118.1"
                     /locus_tag="JQN83_RS12895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQN83_12895"
                     /product="ricin-type beta-trefoil lectin domain protein"
                     /protein_id="WP_208567350.1"
                     /transl_table=11
                     /translation="MFSARSRRHDGEPRRRPGRSAWRPRRLTASVLGVVVTAAAVLTGF
                     AAPAQAATAITINGGSGGRTLDGIGAVSGGGGNSRLLVDYPEPQRSDILDYLFKPGYGA
                     AMQLMKVEIGGDTNSTSGAEPSHEHTRGSINCNRGYEWWLMEQARTRNPNIALVGLAWG
                     APGWIGNGNFWSTDSIDYLVAWLDCAGTHGLTINYLGGWNEKGYNTTWYKNLRSTLNAR
                     GYSSVKIVASDDFGWGAADDSLRDPAFGNAVQVFGSHYVCGYRSAQTNCPSSNNAVSTG
                     KSLWASENGSDDYNAGAQALARGINRGYLDGKMTGYINWPVIAAITPNIPWATTGVAVA
                     QQPWSGAYSIGKNAWVMAQTTQFTAPGWRYLDASSGYIGGNRNNGSYVSLKSTNNSDYS
                     TIVETMDAGGAQTLDFTVTGGLSTGTVRVWSTNVRSNNTADHFVRGSDITPNGGRFSLT
                     VQPGYVYSITTTNGQGKGTATSPAQGNLQLPYADTFDSYATGREARYLMDQQGSFEVVG
                     CAAGRTGQCVRQMSEQAPIYWTSGQAEPYTLLGDLTWRNYTVSSDVLLEKSGYAQLIGR
                     GNTYNHQGPQNMNGYYFRVTDGGAWSIRSNNTSGNWRTLASGNTSALGTGRWHNLSFTL
                     NGSTLTAAIDGTTVGTATDSTWVAGQIGYGTGQGVTAQFDNLSVTAVGSPGTPTGEIRG
                     AGSNRCLDVNGASQTDGAVVQIWDCNGGANQRWSLSSTNQLTVYGNKCLDVPSAASGTR
                     ARIWSCTGGTNQQWRLNADGTIVGVASGLCLDINGGATANGSAVQLWTCNGGTNQQWIR
                     G"
ORIGIN
        1 cccgaatcac gaagatcgcg cagcgtgacg ccaagtccgg tttcgccggt gtggtcgccg
       61 accccaccgc ccgtaagctg caggtcttct ggaagggcga ggcaccggcc agcctggtgg
      121 cgaccagccg ggccaccgtg ccgaccgagg tgctgcccgc cgcgtacacc cgacgggagc
      181 tggacgtcgc ggcggccaag ctgcgccgct cggccggcaa caagatcacc acggtcggcc
      241 cgcgcgccga cggcgccggc ctcctcgtcg gtacgcagag cggcctgctc ggcgcggcca
      301 gcatggccgg cgtcccggtg accgtgcaga ccggggtctc cgccacgccc gccacccggt
      361 gggacgacac cgccccgtgg tggggcggcg gcgcatggcg caacaccgcc accggtggcg
      421 gctgctcgac cggcttcggc gtgttccgca acggcgtcgc gcggctgctc accgccgcgc
      481 actgcgccaa catcaacgtc gtcgcggccg acccgaccgg tcagacgatc ggcgcggtcg
      541 gcatccgcaa caccggcacc gacaccctgc tgctgaccac cagcgcgggc ggccgggtct
      601 tcaacaacag caccgacgcc aacggcgcgg tggtcagcga gttcagcaac caggtgatcg
      661 gcgcgcaggc cagccaggtc ggcaacttcg tctgcacctc cggggcgtac tcggggaccc
      721 gctgctcgat ccaggtcaag gcccgcgacc tgtgcatcaa cgtacgtgac ttcgccacgg
      781 tctgcggcca ggtgcaggcg gagagcacca cccgtaccaa cgcggtcggc cagggcgaca
      841 gcggcggccc ggtggagatc gtcaacgcgg cgaacaccct ccaggtctgg gccaccggca
      901 ccaacaccgc catcgacgac gtcaacacgc tgacggcgtg caccggctac gttcccgcca
      961 accgcaagtg cgcctggcgg atgtactacg aggacatcaa ctccgggatg ttcggcgtca
     1021 gcgccacggg cgtggtcctc ggctgacgga cccggtcccc ggtcgacgag ggctggcgga
     1081 ggagggtcgg tcggcggggc aggctccgca accgtcgatc gacccggcgg ccgggtcggc
     1141 gtgcgtccag cacgccggcc cggccgttcg tcgtccaccg gcccggccgt tcgtcgtcca
     1201 ccgggcaggc gggcgcggtg gcgcgtcagg cgttcgggcg tcgggggccg gaccaccgcg
     1261 ggcggtcgac gccactgcgg cgacgccgtc gaaaatcacg aattcagcgg agattgtcgt
     1321 caatgaaacg gtcgactccg ggcactgttc ggaggttcgg cgcgtagcgc ggattatccg
     1381 aacagagacg tacaagcctc tcatcatccc cacaacccaa taaccaccga acaactagac
     1441 gtatttgaat ccttgcgttc ggcacacggc attgttaacc tcatacgcac cccactccac
     1501 attggggtaa aggaattcag ccccggatcg cgcgaactcg taccgaaaaa cctcgcaccg
     1561 atatttggga aaatcatgag cacaatgcgg ccagggcaat gacggctgcc cccagccagg
     1621 aaacaaaacc cgcaaatagc ccccaccggg gccgtgattt ccgcctctac tggatcgccg
     1681 gcgcaatcga ccaactcggg tcgcaggcgt ccgggatcgt tcttcccctg gtcaccctgg
     1741 ccgtgaccgg ctcaccggcg gcggccggac tggtcggcgc cctcgccctc gccgggcggc
     1801 tcgtcgccgc tccggtggcg ggggtgctgg ccgaccggct gccgcgtaaa cgcatgatgg
     1861 tcagctcgct gctggtcgcc gccgccgcga tgtcgacgat cttcttcgta ctggtggccg
     1921 acgtggcgac cctcggcctg ctggccgccg cagcgttcgt cgaggggatc gcgcagagcg
     1981 gctacgaggc ggccggctcc ggtgccatcc gccgcctgct gccggccgac gaccagaagg
     2041 cactgtcgcg gttggaggcc cgcaaccacg ccgcccggct caccggcccg ttgttgggcg
     2101 gggtgctcta ccagctcgcc cgctggctgc cgttcctggc ggacgtgctg tcctacctgc
     2161 tcgcggcagc tctcgtcgcc accatccgga ccgacctgac acccgaacgc gccgagcgca
     2221 cctcgttccg caccgacctg cgcgtcgggc tgcgcttcgt gtggcggcag ccgttcctgc
     2281 ggttcgtcac gatctgggcg gccggcatca acttcacctt cggcgccctc gtctactacg
     2341 ccatcctgac cgctggtcgg cagggtgccc ccgcggcgtc gatcggcctg atcctcacca
     2401 tcgccagcgt cggtggcctg agcggcgcgc tggccgctcc gatgatcttc agccgggtcc
     2461 ggccgacgac cgtcatcgtg ttcgcctcgt gggccatggt cggcctcgtc gtcgcgatgt
     2521 cccaggcccg gcagacctgg agctacgggc tgttgttcgg gttggtcttc ctgctcagcc
     2581 cgctgctcgg ggtcatcttc cagtcccggg tgatcgcgtt gacgcccgac gaactccagg
     2641 gtcgggtggc gaccgtgatg ggcaccgtcg gcgaggcgct ccagacgccc gcgccgctgc
     2701 tcgccggggt gctggtggcc tggtacagcc cgggcaccgt cgccctggtc ttcgccgccg
     2761 cgctggcgct gctggccacg tacaccaccg tcagcctgcg ccagctccgc gccggcgccg
     2821 gtgcgacggc cggcaccgac cccggcccga ccgacggcac cggcccgacc gacggcaccg
     2881 atcccggccc ggccgccggt gccgcccccg accccgagga ggcccgccga tgagtcgtgg
     2941 tcaccggctg ttctatccgg cgctgccggt cgtcgccgag cacgcgccgc accgggcggt
     3001 ctacgtcggt gacgccgggg ggcgctgcga gatcctcacc tgggaccggc tcgccggcac
     3061 cgcccggcag gtgaccgacc gggcggccgg cacgatccgg gcggcgctcg acccgaccgg
     3121 gtccaccatc tggtggttcg acgacgatct cggcggcgtc ggcacctggc ggacgtgcga
     3181 cttcgaccag cccgaccggt ccgtcgcggc gctgccgtcg gtgccgccgg cccgccacgc
     3241 cggcatcgcc atggccaccg acggcaccac cgcgatcggc ctgtccgacg acggcgggat
     3301 gaccctgttc ctgcgcaccg gcgacggccg ggtgagcgaa cggacccacg tcaccggcta
     3361 cgcctacctg gtcgatctcg atccggccgg gcggctcgcc gtgatcggcg ccgatgccgc
     3421 caccgacgcg gcggtcacgg tggtcaccac cgacggcgtc cgggtggccg gcatcgccgg
     3481 ttgcgccgac gggcgggtgt gggccctcgg tttcgccccc ggctccggcc cggcccggct
     3541 gctgctggtg atcgaggacg agggcggcta cctcccggcg acctggaccg aagaggaagg
     3601 tctggtccgg cacgactggt gccgcttcga caccgaggtc accgccggtt ggttcccgga
     3661 cgggcggcgg ctgctcgtcc ggcaggaccg gcacgcccgc agcctgctgc acgaggtgga
     3721 cctcgccggg cggacccggg cggtcgtcga cacccccacc ggcagcatcc tggacgccgc
     3781 ggtgtggccc gacggggacg tcgcctacgt gtggaccgac tcggtgaccc cgccccagct
     3841 gcgttccgtg cgtggggtgc agctgccgga gcaccccggc ggtcagcccg acgtgggcgg
     3901 gccggacccc gtcgcgacgc cggtggagca ccgccgcgag gagatccggg tgccgggccc
     3961 cggtgggccg atccccgcgc tggtcgccct gccggccgac cggcagggac cgagaccggc
     4021 cgtcttcctg gtccacggcg ggccgttcca gcacgcccgc gacgcctacg acccgctggt
     4081 cgagatcctg gtcagcaccg gctgcgcggt ggtccgggtc aactaccggg gctccagcgg
     4141 gtacggcgcg acctggcgca acgacttctc cgccggggtc ggcctcaccc agttggcgga
     4201 cctcgccgcg gtccgggccc acctggtcgc cgcgggcgtc gtcgaggacc ggcgcaccgc
     4261 cctgtgggga acgtcgtggg gcggctacct gaccctgctc gcgctcggcc ggcaaccgga
     4321 gctgtggcgg ctcgggatcg cgatcagccc cgtcgccgac tacgtcgccg cgttcgaggc
     4381 ggccaccccg gcggtacggg cgctggacgt gctgctgttc ggcggcaccc ccgacgaggt
     4441 gccgcagcgg tacgcccggt cctccccgat cacctacgtc gaccaggtcc gggccccggt
     4501 gctgctggcc gtctccacgg gtgacgtgcg ctgcccgccg gcaccggtgg agcactacgc
     4561 gcggctgttg gccgagcgcc gcattcccca ccaggtggtc cggcggcggg ccggtcacga
     4621 ggacttcgac gcgcagagcc acctggctct gatgcagacc gtgctgctgt tcatgcagcg
     4681 gcacttcgac ggcgtgcggg acgaaggcac accggtggcg ctcgcgatgg cgcgaccggc
     4741 gggctgaccc cggcacgtga cccgatcccc tcgataacgg aaaggaggtg aacgacatgc
     4801 gcaagaacgt tgtcgagaac gacccgatca acggcaaccg cgaccagctc cgggcctcga
     4861 acgtcacggt cacggtcacg gtcaaggtca gcttctagcg gccgtacggg gtggggccac
     4921 ccgcccgggc aggtggcccc accccgtatc cgtcatccgg tccgaacagc tcacgagaga
     4981 ggagaggtta cgtgcgggtc atgctggtca atatgccatg gacttccatc gacgtccctt
     5041 cgttggcgat tggaatcctc accaacagtg tccggcagaa aatgccggat gccgaagtgg
     5101 aggccgtcca cgcgaatctc gacttcgtcg actgggtggt cgaccggacc gagttcggat
     5161 tgagcgacta ctactactat tcgctgttca cctatttcgc gggctgtggt gactgggtct
     5221 tctcctcggc cctgtacgac gatccccaat ggcgggtgca ggagttcacc gaccgggtcc
     5281 ggacccagat gaccgaacgg gaactcgcgc tcaacctgga gctgcaccgg ctggccccgg
     5341 aattcgtcgc ggaactggcc gaccggatcg tcgcccaggc accggacgtc gtcggcttca
     5401 cctccacgtt ccagcagaac gccgccgccc tcgccaccgc ccgggcgatc aagaagcggt
     5461 cacccggcat ccgtaccgtc atgggcggcg cgaactgcga cggtgagcag ggtgccgcga
     5521 tccaccgcaa cttctcgttc gtcgacttcg tggtccgggg tgagggcgag accgcgttcc
     5581 cccggctgct cgccgcgctc gacccggccc ggtcggcggc cgtcggggcg gagccggcgg
     5641 gcgggctcgc cgacatcgaa gggctgtgct ggggcggccc ggacggccgg tccgtggcga
     5701 atccgatgag caccacaccc ctgcccccgg ccgagatcgt cgccccggac tacgcgggct
     5761 acttcgagcg gttggccgcg tcccgggcgc agcactgggt cgagccccgg ctggtcgtcg
     5821 agggcgcccg gggctgctgg tggggcgaga agcaccactg cacgttctgc ggcctcaacg
     5881 gatcgttcat gcagttccgc agcaagcacc cgggcaggtt ctacgacgag atcatcgagc
     5941 tggtcgagcg gcaccaggtc ctggacatgt tcgtcgtgga caacatcctc gacatgagct
     6001 acgtgacctc gctgctaccc cggctcaccg aatccgacta cgacctgcgg ttgcagtacg
     6061 agatcaagtc gaacatgaag ggcccgcagg tgcaggcgct ggccgacgcc ggtctggtca
     6121 gcgtgcagcc cggcatcgag agcctcaaca gccgggtgct caagctgatg gacaaggggg
     6181 tcagcggctg cctcaacatc cggatgctgc gtgacgccga gaccagcggg atcaccatcg
     6241 cctggaacta cctgtacggg ttccccggcg agaccgagga cgactacctg ccggtgatcg
     6301 cgcagatgcc ggcgctgcac cacctgtgcc cggccgacgg gagcacccgc atcgccatcg
     6361 agcggttcag ccccttcttc gtccgccccg aactcggctt caccgacctg cggccggcgg
     6421 cccagtaccg gctgatctac gacctgcccg agtcggagct gatggacctg gcgtacctgt
     6481 tcgacgtacc gccgcagggc atcggcggcg agacggccga ccggctggac cgggcggtca
     6541 ccgagtggca gcacgagtac gcccgcagcc ggctcaccca ccacgacctc ggcgacgaga
     6601 tcgtgctggt cagccgacgc aggcacttcg actggcacgt cctgcggctg accgacccgg
     6661 tggaggtggc cgtgttccgg cagctcgacc agccgcacag cgtcagcgcg ctggcccggc
     6721 ggctgtcggt cgacgagccg gtccttacgg cgttgctgcg gcgctggcgc ggtctcggcc
     6781 tggtctacga ggacgccggg cagttcatcc agatcgcccc gcaggccatg aaccaggatc
     6841 tgctgcgcat cgaccacctg cacctggaac gtgaagccgc cgagaccagg gccgccgccg
     6901 aggcgggcga gccggccgcg ctcagcgcgg tctgagggga gggaacgtgt ccaccatcga
     6961 cgccggtctg cggcccatcc tggtcggtct cgcccgggac cacgacccgg ccgtcctgtc
     7021 catccccggc atgaccatcg gtccggccga gctgcgtgag ccggccgccg acgcggtcgc
     7081 ccgctggcgt tctgcggggg tccgtcgggt cgaccttccc gacgtggtgg acctgacggt
     7141 caccggggac gacgcgacgg ccgtcgacac ggtccgccgg ctggtgctgg tccgggagct
     7201 gaccagccac ggtatcgccg tggactggcg gctgcggctg cccggtgtcg aggccgacga
     7261 gtggctcccg tacagccacc tgcgggcgcc ggtcgaactg ctccccgcgc cggggggcga
     7321 gggcgacccg gtcgcgcagc tcgacgcctg ggtgaagggt ttctacttcg acaagtgcac
     7381 ctaccgtcgg ggcccggggt tcgtccaggt gcgggaccgc cgcgccggtc ggttgaacct
     7441 gctgaccatc gacgatccgg cctacctggc ggtgctcgac cagttgctgg acggtgccgc
     7501 cgtcaccggg gtcgacctct ccatcgcccg ggacttcggc gcggagggcc tggtcaccaa
     7561 gatcggcgag ctgctggtgt ggctgccgca ccggctgcgc cgctggcccc tgccgtcgat
     7621 ggtgatctga ccgcccggcg ccggccgcgt caccgaccgc ccgaccgccc gcccgcgacc
     7681 ccgggccggg tgggcgggcg gtctcgcgtt cgccccggct ggcggttccc gaaagtttcg
     7741 ggtatacagg gaaggcggct ccgttgaggt cgaattaata cctccccctc gcgggcccat
     7801 ctcggtgaca gccgacgtca acccgtcgaa atccgccccg cgtccggccg ccgctcgggg
     7861 cgatgtttcg ggaagatttc cgaaacttgt tgacaggtgg agcatcgaca ccctaccgtc
     7921 gccatcgacg gcactcgatg ctgtcgacac cacccaccgc gacccgtccc cccggttctg
     7981 ctggacgacc ggcccaccac cgcgtggtga cacccaccgc atggccggct gccgtacctg
     8041 gccacggaca gtccaccggg tcgtaccgcg tcgctggcgt ccgccagctg tcacgaggag
     8101 gaacacgtac atgagcgaca cctcgacccg accgcgaagg agcggtcgcc tgcggctgct
     8161 gctcagcgcc gcgtgcgccg cggcgctcgc cgtcaccggc acgttcatcg cctcgcccaa
     8221 cgcgtacgcg gagaacgacc ggaccctcac ctccaacctc accggcacgc acaacggcta
     8281 cttcttctcg ttctggaagg acagcggcaa cgccagcatg acgctgcgcg ccgacggccg
     8341 ctacagcagc agctgggacc gcagcaccaa caactgggtc ggcggcaagg gctgggccac
     8401 cggcacccgg cggacggtca gctactcggg cagctacaac ccgggcaaca acaacaccta
     8461 cctggccctg tacggctgga cccgcaaccc gctcatcgag tactacgtgg tggagaactt
     8521 cggcagctac aacccgagca gcggcgccac ccggatgggc acggtgacca ccgacggcgg
     8581 cacctacgac atcctgcgca gcctgcgggt caacgccccg tcgatcgacg gcaaccagac
     8641 gttctaccag tactggagcg tccggcagca gaagcgcagc agcggcacca tcaccaccgc
     8701 caaccacttc gacgcctggg cccgcgccgg cctgaacctc ggcaccaacc acagctacca
     8761 gatcatggcg accgagggtt accagagcca gggcagctcc gacatcaccg tccgcgaggg
     8821 tggcggcagc aacccgacca gcgggccgac cggcaacccg accaccccgc ccgccggcgg
     8881 caactgcacc gcggtgctct cggccgccga gcagtggggt gaccggttca acctcaacgt
     8941 cgcggtcagc ggcaccagca actgggtggt cagtctcggg ctcaacggcg gccagagcat
     9001 ccagaacagt tggaacgcct cggtcagcgg caccaccggc accgtcaccg ccaggccgaa
     9061 cggcaacggc aacaacttcg gcatcaccat catggcgaac ggcaactgga cctggcccac
     9121 ggtcagctgt cgaacggcct gaccccgacc agttcctgag cgcacgcgac ggcgggcggt
     9181 cccggtgcca ccgggaccgc ccgcttgctg cgtcaggtgt cgctggtcag ccgcgtatcc
     9241 actgttggtt ggtgccgccg ttgcaggtcc agagctggac ggcggagccg ttggcggtgg
     9301 ccccgccgtt gatgtccagg cacagcccgg aggcgacccc gacgatggtg ccgtcggcgt
     9361 tgagccgcca ctgctggttg gtgccaccgg tgcagctcca gatccgggcc cgggtcccgg
     9421 atgcggcgct cggcacgtcg aggcacttgt tgccgtagac ggtgagctgg ttggtggagc
     9481 tgagcgacca gcgctggttg gcgccgccgt tgcagtccca gatctgcacc accgcgccgt
     9541 cggtctggct ggccccgttg acgtcgaggc accggttcga gcccgcgccc cggatctcac
     9601 cggtcggggt gcccggggag ccgacggcgg tcaccgagag gttgtcgaac tgggcggtga
     9661 cgccctggcc ggtgccgtac ccgatctggc cggcgaccca ggtggagtcg gtggccgtgc
     9721 cgacggtggt gccgtcgatg gcggcggtca gggtgctgcc gttgagcgtg aacgacaggt
     9781 tgtgccaccg cccggtgccc agcgccgagg tgttgccgct ggccagggtg cgccagttgc
     9841 cgctggtgtt gttgctgcgg atcgaccagg ccccgccgtc ggtgacccgg aagtagtacc
     9901 cgttcatgtt ctgcgggccc tggtggttgt aggtgttgcc gcgcccgatg agctgcgcgt
     9961 agccggactt ctccagcagc acgtcggagg agaccgtgta gttgcgccag gtcaggtcgc
    10021 ccagcagggt gtacggctcg gcctgcccgg aggtccagta gatcggggcc tgctcggaca
    10081 tctgccgcac gcactgcccg gtgcggccgg cggcacaccc gacgacctcg aacgagccct
    10141 gctggtccat caggtaccgc gcctcgcggc cggtggcgta cgagtcgaag gtgtcggcgt
    10201 acggcagctg caggttgccc tgcgccgggc tggtcgcggt gcccttgccc tgcccgttgg
    10261 tggtggtgat gctgtagacg tagccgggct ggacggtgag cgagaagcgc ccgccgttcg
    10321 gggtgatgtc gctgccccgg acgaagtggt cggcggtgtt gttggagcgc acgttcgtcg
    10381 accagacccg taccgtgccg gtggacaggc cgccggtgac ggtgaagtcg agggtctgcg
    10441 cgccaccggc gtccatcgtc tcgacgatgg tgctgtagtc gctgttgttg gtggacttca
    10501 gcgagacgta gctgccgttg ttgcggttgc cgccgatgta cccgctcgac gcgtcgaggt
    10561 agcgccagcc cggtgcggtg aactgggtgg tctgcgccat cacccaggcg ttcttgccga
    10621 tcgagtaggc gccggaccag ggctgctggg ccaccgccac gcccgtggtc gcccacggga
    10681 tgttgggggt gatggcggcg atgaccggcc agttgatgta gccggtcatc ttgccgtcga
    10741 ggtagccccg gttgatgccg cgggcgagcg cctgcgcgcc cgcgttgtag tcgtcggagc
    10801 cgttctcact ggcccacagc gacttgccgg tggagacggc gttgttggag ctggggcagt
    10861 tggtctgggc gctgcggtag ccgcagacgt agtggctgcc gaagacctgc acggcgttgc
    10921 cgaaggccgg gtcgcgcagc gagtcgtcgg ccgcgcccca gccgaagtcg tccgaggcga
    10981 cgatcttgac gctgctgtag ccacgggcgt tgagggtgga gcgcaggttc ttgtaccagg
    11041 tggtgttgta gcccttctcg ttccacccgc ccaggtagtt gatggtcagc ccgtgggtgc
    11101 ccgcgcagtc cagccaggcc accaggtagt cgatcgagtc ggtggaccag aagttgccgt
    11161 tgccgatcca gcccggcgca ccccaggcca ggccgaccag ggcgatgttg gggttacggg
    11221 tacgggcctg ctccatcagc caccactcgt agccccggtt gcagttgatg ctgccccggg
    11281 tgtgctcgtg gctgggctcg gcgccggagg tggagttggt gtcgccgccg atctccacct
    11341 tcatcagctg catcgccgcg ccgtagcccg gcttgaacag gtagtccagg atgtcgctgc
    11401 gctgcggctc ggggtagtcg accagcagcc ggctgttgcc accgccgccg ctgaccgcgc
    11461 cgatgccgtc cagcgtccgt ccgccggacc cgccgttgat cgtgatggcg gtcgccgcct
    11521 gtgcgggtgc ggcgaagccg gtcagcaccg ccgccgccgt caccaccact cccagcaccg
    11581 atgcggtcaa ccgacgcgga cgccacgcgc tgcgccccgg tctgcggcgt ggctcgccgt
    11641 cgtgtcgacg gctgcgtgca ctgaacatgt gactcgcctc cccagccggt ctccgacctc
    11701 gaagcggtac ggcacacgtc gaactgtcgc accccgcgca gcacggaaat cggcgaacat
    11761 caatgataag acgtcgtatg ttaggcaccg cagcgcttac cggtcaacgt cctgttcgga
    11821 gggaaataat ccatactcac ccgcaccgca cccacctggg aatcccgaat agatcagatg
    11881 tatggactct gctgtgacgg gcgggaaaac gggacacgcc gccgacccgg acgcc
//
