LOCUS       NZ_JAFJXZ010000017     24557 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Paenibacillus polymyxa strain Hob6 Scaffold_17, whole genome shotgun
            sequence.
ACCESSION   NZ_JAFJXZ010000017
VERSION     NZ_JAFJXZ010000017.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 2906550)
  AUTHORS   Mahmoud,M. and Jabaji,S.
  TITLE     Draft genome sequence of Paenibacillus polymyxa strain Hob6,
            isolated from hemp (Cannabis sative) seeds' oil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 2906550)
  AUTHORS   Mahmoud,M. and Jabaji,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-FEB-2021) Plant Science Departement, McGill
            University, 21111 Lakeshore, te-Anne-de-Bellevue, Quebec H9X 3V9,
            Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 22-JUL-2020
            Assembly Method                   :: SPAdes v. 3.12.0; Medusa v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly :: GCA_000507205.2; GCA_014706575.1;
            GCA_000164985.2; GCA_000597985.1; GCA_002893885.1
            Genome Coverage                   :: 266.29x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017589695.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 02:57:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,119
            Genes (coding)                    :: 5,024
            CDSs (with protein)               :: 5,024
            Genes (RNA)                       :: 156
            rRNAs                             :: 21, 9, 15 (5S, 16S, 23S)
            complete rRNAs                    :: 19, 2 (5S, 16S)
            partial rRNAs                     :: 2, 7, 15 (5S, 16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 44 of 95
            Pseudo Genes (incomplete)         :: 63 of 95
            Pseudo Genes (internal stop)      :: 13 of 95
            Pseudo Genes (multiple problems)  :: 21 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 706731
            Orig. end                         :: 731288
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAFJXZ010000017.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..24557
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="2"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..24557
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24557
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14557](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14557
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(118..1743)
                     /locus_tag="JYU28_RS14085"
                     /old_locus_tag="JYU28_14120"
     CDS             complement(118..1743)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312216.1"
                     /locus_tag="JYU28_RS14085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14120"
                     /product="ferredoxin--nitrite reductase"
                     /protein_id="WP_039271414.1"
                     /transl_table=11
                     /translation="MAYEPIWNAHPDKLNKFELVKLEKDGLDVIRTIIENYANEGYDSI
                     SADDMDRFKWAGVYQQKPKDGHFMMRVRINTGIMTSAQAHALADISALYGRGLVDVTTR
                     QAIQFHWLTVESLPDIFERLEKVNLYSFEACGDCPRTIVGNPLAGIDPNELVDTQEIVD
                     EVNRFFLLNRDFSNLPRKYKMSISGNTYNNAQAEINDLSFTPATKILDGKEVIGFHVMV
                     GGGLSAKPHMAQSLDLFVRPEEVLKVAIAVTTIFRDYGYREKRHHARLKFLVVDWGPDK
                     FLAKLTEYIGEMPGRGEDKTIGWQAAYFDGVHPQAQKGLNYVGLNVPVGRLSADELHEL
                     AELADRYGDGQIRTTMSQNILLSGVPDEQVDELLEAPVLQRLTPRPKHFMSRTVSCTGN
                     EFCNLAIVETKKRAVDVAEYLDQHVQLDEKVRIHFIGCPNSCGQKHIADIGLQGSLIKT
                     PEGLVDAFDIAVGGALGAGAQFNKALKGRVRGDQVGPVLAELILFYKENRSAGESFYAY
                     VQRVGIPTFQEKLSAILQSSHVAS"
     gene            2103..3347
                     /locus_tag="JYU28_RS14090"
                     /old_locus_tag="JYU28_14125"
     CDS             2103..3347
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010349608.1"
                     /locus_tag="JYU28_RS14090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14125"
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_029514532.1"
                     /transl_table=11
                     /translation="MRKMGKRAVVLALGSALCVSGTAGAASSGTALKAKVINGGVYVNV
                     SDMNKALGTSGAYNSANGTYTLSAGRVPQVVKNVSPSVVGIIGRSATGETVAGGDRYNL
                     AHGTGVIIRTDGWIVTNAHVIEGLGDAVVVTSDGKSYGITDSYSDPISDLALVKIKASG
                     LKPATLAASTNSLQVGEQVVAIGTPISFSLRNSATSGVVSGLNRGVNAAYRLIQSDTAI
                     NPGNSGGPLVNLKGEVIGINTMKFSAVGIENMGFSIPADTVKYVIGQFFKYGEVRRASL
                     GLGLEESWSAIVGLPTEDPLKVTKITSANAVQAKIKEGDELYSINGKRVASAIDVNELL
                     KNYQPGQTVSVLMQSDGDIVKRKLVLTQDNGEIYESIQSGEDSEDSNGSEAAEDGGVAP
                     SKEASEPAQGATTGK"
     gene            3397..5310
                     /locus_tag="JYU28_RS14095"
                     /old_locus_tag="JYU28_14130"
     CDS             3397..5310
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312214.1"
                     /locus_tag="JYU28_RS14095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14130"
                     /product="stalk domain-containing protein"
                     /protein_id="WP_029514531.1"
                     /transl_table=11
                     /translation="MKHIQRKMMRKLGVGAVALSLLLSALPAVAADHDKTMLELRLQSG
                     SNTAIVNGHNANITKPYSKSGALMVPAGVFKKAFNSKIRLAEDNVVKITSGTHVVSLTI
                     GSRTAWVRGHKVTLPAPPEMSSGILMVPLRQVAEGLGGKLEKNGAGIIIRMEAQEEAGT
                     VAEETPNIDNDEGKTQIGNSYYDWSMNYPTGLVIGQGGGDESISTFMDENSAYYMEVHT
                     ASQPVPLNADDLLQQLVQAAKETGETVIDRKSFPKAKVPYARVITKDGDGVLWENRQYY
                     DNGRLYVVYFSDAKATNYKDLAQYAGLLNSFKTSFNAQDKSIKDLSTVVGGTREAGNPD
                     YGVSLSIPAGWKMDDQRMQYESNDGSSFRVKVTSAPADGKLENWGQQLQKWLSDSFVST
                     AYEAQKTYPLEVAGVQGLVQEYRYNFGDGWVKEYNVLIQQNGYRYLAEYAVPEKVSKGN
                     DQFNALISSLQIDFQTVASNFGQLEEDDYLTDKTKTVKKTSKAYEYTVNIPRYWTAISD
                     QFELGDVEYQFTGGRFSIKIDNDQSFELTVSQLKDFYDKQAKNYKNLKVEEVKDVTFAG
                     VPAVSFTFHRIEEGIGYTGHQLVLERDGKTYTVTTTLNDANNTAIQSNALDSTLNSFNF
                     VK"
     misc_feature    5568..5577
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 16.42"
                     /tool="antismash"
     misc_feature    5604..5619
                     /note="TFBS match to ClgR, Caseinolytic protease gene
                     regulator, confidence: weak, score: 21.31"
                     /tool="antismash"
     gene            6064..8574
                     /locus_tag="JYU28_RS14100"
                     /old_locus_tag="JYU28_14135"
     CDS             6064..8574
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822969.1"
                     /locus_tag="JYU28_RS14100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14135"
                     /product="U32 family peptidase"
                     /protein_id="WP_029514530.1"
                     /transl_table=11
                     /translation="MKSVVRREDVELLAPAGDWDCMRAAVANGADAIFFGVEKFNARAR
                     ANNFRMEELPEIMAFLHSYGVKGFLTFNILVFENELEDAKELVDACIDAGVDALIVQDM
                     GLVKMIRDISPDFPIHGSTQMTITSPEAVEFTKPYNMERVVLGRENNLKQIQKIGDQAR
                     LPMEVFVHGALCVSYSGQCLTSEMWGGRSANRGECAQACRLPYDLMVDGEQKPMADVTY
                     LLSPKDLAAIDLMPELIDAGVVSFKIEGRLKTPEYVANVVSKYRKAIDKYFDGDTSKTS
                     KEDIRELQQSFSRGFTHGFLEGTNNKKLVDGTFPKSRGVYLGRVEQILRDGVVCRIDAP
                     LKRGDGIVFDAGDPTQKEEGGRVYDIRRKGVKIEGEAGEGWIIDIVAGRNDVDLRRVHV
                     GDRIWKTNDPALDKRLRQSYDTDKPYRVFPVHVRVSGSPGQPLSTWWTDVQKGTTVRVD
                     SELELEIAQKRPMTHELLEEQFGRLGGTVFQLEELDVHLHGDVIVPMRELNGIRRQAVE
                     LLAGERPKPPVYTKRAVEVYDDASTPASSVARGQAELTALCRSLPQVEAALEAGVEFIY
                     ADFEFIKQFPAAVEAVHAAGRRIALATPRIHMPGENGYHNNILRLKPDAVLVRNPGALY
                     FYLRHRLENPDAHHPQLIGDFSLNIANHKAADLFLDSGCDLVTPSYDLNIQQMVDMLRR
                     TRTDKLEIVIQQHMPMFHTEHCVYCTFMSEGTDYTNCGRPCEDHRASLRDRIGMSHPVR
                     VDEGCRNTVYNAIEQSGAEYLSNFLELGVSRYRVEFLEETPEQVHEVIDLYNRALRGEI
                     SGTQVWKTLKATNQLGVTRGQLVK"
     gene            8770..9660
                     /gene="galU"
                     /locus_tag="JYU28_RS14105"
                     /old_locus_tag="JYU28_14140"
     CDS             8770..9660
                     /EC_number="2.7.7.9"
                     /GO_function="GO:0003983 - UTP:glucose-1-phosphate
                     uridylyltransferase activity [Evidence IEA]"
                     /GO_process="GO:0009225 - nucleotide-sugar metabolic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="galU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064: glucose-1-phosphate
                     adenylyl/thymidylyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312210.1"
                     /locus_tag="JYU28_RS14105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14140"
                     /product="UTP--glucose-1-phosphate uridylyltransferase
                     GalU"
                     /protein_id="WP_069010697.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 4.1e-09, bitscore:
                     34.2, seeds: 297, tool: rule-based-clusters)"
                     /sec_met_domain="Glycos_transf_2 (E-value: 1.7e-06,
                     bitscore: 25.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEEAV
                     ASGIEDIIIVTGKGKRAIEDHFDYSFELEHNLTAKEKWNLLNEVRKPSEMADIHYIRQK
                     EPKGLGHAIWCARKFIGDEPFAVLLGDDIVESENPCLKQMIDVFDEYQRSVVGVKQVNW
                     NEVHRYGIVEGHALTSKISEAERLVEKPKKEETNSNLAIMGRYILTPDIFDILGQQSAG
                     VGGEIQLTDALSKLGEKSPILAYEFDGNRHDVGEKLGFIETTIHYALQHNEIKDEVLAY
                     MRQVIEGIDENITKL"
     gene            9762..9926
                     /locus_tag="JYU28_RS14110"
                     /old_locus_tag="JYU28_14145"
     CDS             9762..9926
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="JYU28_RS14110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14145"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_176715693.1"
                     /transl_table=11
                     /translation="MNSLELFVLEQEDTLDLDLQVNAFSSEPVTMACTGTVTCAVSACY
                     DTYVTCNCC"
     CDS_motif       9762..9854
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNSLELFVLEQEDTLDLDLQVNAFSSEPVTM"
                     /locus_tag="JYU28_RS14110_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9855..9926
                     /prepeptide="core"
                     /locus_tag="JYU28_RS14110_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-1.30"
                     /molecular_weight="2244.6"
                     /monoisotopic_mass="2242.9"
                     /core_sequence="ACTGTVTCAVSACYDTYVTCNCC"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNSLELFVLEQEDTLDLDLQVNAFSSEPVTM"
                     /leader_location="[9761:9854](+)"
     gene            10001..13213
                     /locus_tag="JYU28_RS14115"
                     /old_locus_tag="JYU28_14150"
     CDS             10001..13213
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016822973.1"
                     /locus_tag="JYU28_RS14115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14150"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_069010698.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.4e-179,
                     bitscore: 593.9, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 1.7e-12,
                     bitscore: 45.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 5.4e-36, bitscore:
                     121.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGIRHRNENRNLFRALDFFLVRIPLLPVEMYNELFYEPSYENLR
                     NKLLHMVKEPIVCEALLIASPSLMHSVNQILDNSNSKKADKIIKAIAHYMIRLSTRATP
                     YGVFAGVAMGSFESESRLVIGDLSFHRKIARPDMQWLMDLVKGLERIRHVVEQVEVRTN
                     SILYTSGSRVKLPYLNYIDHFDSSDEMKSSSIRISKFVDYVIHCAKQPVPILKLMDKMK
                     EEFPTINQEQLFGLLLKLVEQEFLISNLRPPLSIRNSELPFEYIKGQLASMTGIDDLKA
                     SIQKIYNYIQQYNQTSVGEGEELYTNICSSINEMFPSKDPLQIDMETAITNATLSHEIA
                     EEVAIAAEVLWRLSNNVCNPHLATYRGAFIEKYGVHRQIPLLELLDEDMGLGAPPDYKY
                     PMSKRSWEKSTANADRDKHLARWVAEAIKQGSIEIELTDEKIRKIECAPSELSPPPSLE
                     MYVTVATSDATALEGGDYKLIVNPNSGGTGAGKTFGRFGPILDGSAQKQISSIYKIQSD
                     QNPNVIFAELIYLTINSRHSNVVITNRSCSHQIILGTNDYTDDRASTISLADLYVGCTH
                     DSFYLMSRSLNKRVIPVATNMLNYYKAPNVYRFLREMEQEGQRNVSMFQWGNHLSELPF
                     LPRIRYGNTILSLASWSLNADMKAFQNCHTKSDWRNAFERLKKEWSIPRYVYITIADNR
                     LLIDTTHDFCISELYDKYQKLTDSASIWLTECGFEWSEVWGESTKGHHIAEYVIPLVKT
                     NKVGQSRSKDLIQPDMMQNPISTRSMDVYFPGSEWLYVKLYGMSERKEEFIGNYLRPFC
                     ELAEKQKIVDQHFIIRYKDPDDHVRVRFHGDAAMLCAQLIPAIQTWANKLKKEGLLNQL
                     VYDTYEQEVERYGGGSFIQLAEEVFAADSKLASEFIYLHYNKKWNMPLEDIALISVIDM
                     LNQWMPSLAKQVEWSQQKEWHNHHIKEFQKNRTWYMSICDVSDRWSSLRACNYGEFMIE
                     RFQPRREKLKQYKERFFQKKKETCWDGPLLDIMESFIHMHLNRLLGTDRMKEAKIMSLL
                     SHALYHLNHAQKYTKRMNYKEC"
     aSDomain        10487..10759
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JYU28_RS14115_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-14"
                     /identifier="RREFam001.1"
                     /label="JYU28_RS14115"
                     /locus_tag="JYU28_RS14115"
                     /protein_end="253"
                     /protein_start="162"
                     /score="45.2"
                     /tool="antismash"
                     /translation="NSILYTSGSRVKLPYLNYIDHFDSSDEMKSSSIRISKFVDYVIHC
                     AKQPVPILKLMDKMKEEFPTINQEQLFGLLLKLVEQEFLISNLRPP"
     gene            13217..14557
                     /locus_tag="JYU28_RS14120"
                     /old_locus_tag="JYU28_14155"
     CDS             13217..14557
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019688744.1"
                     /locus_tag="JYU28_RS14120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14155"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_069010699.1"
                     /sec_met_domain="LANC_like (E-value: 2.2e-65, bitscore:
                     218.0, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MITTGISEDLRQTILEIVHEVGRRLADSDYVTAMCSSDSNRTDLQ
                     LDYKWDEISLASGYPAVSLLYGRLGTVFREETFTRYAHQYLVNTREALKLKENISLSLW
                     SGLSGIGFTAYALSDNLRKYRSFIEQINHLILRYGAALLESSRNNLKAGVIFHDYDVIS
                     GWSGIGRYLLLFKDVPEMRDLLKDVLEYLVMLSEERAWNGEVLPGWYIPVHNLPPHEQQ
                     RYPEGYFNMGLAHGIPGPLALLSIAWHHDVRVSGHKKAIERFGSWLSHWKQQNDFGWYW
                     PNNISYREYMNGIIFDETEREAWCYGTPGVARSLWLAGRALENEKLEALAVDAFKSIYA
                     RPRERWSIYSPSVCHGYSGLIKLTHQMYLDTGDAELRDYAQGLLLEVVNMFDRGAAFGF
                     WDIVKDTQSVKHLDFVGVLDGVAGIVMTLLDTLESEESIWGRSLLIT"
     gene            complement(14671..17130)
                     /locus_tag="JYU28_RS14125"
                     /old_locus_tag="JYU28_14160"
     CDS             complement(14671..17130)
                     /GO_process="GO:0009103 - lipopolysaccharide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Wzy_C"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013373313.1"
                     /locus_tag="JYU28_RS14125"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14160"
                     /product="O-antigen ligase family protein"
                     /protein_id="WP_069010700.1"
                     /sec_met_domain="Wzy_C (E-value: 2.5e-16, bitscore: 57.4,
                     seeds: 81, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNPVYGKQAKTSTHDDKRPAMFWVLIVGMILFLAWSPFQAALFN
                     GQMLEFEKPLYCALIISMILLILGIATYYKKFKLEDQRDWLAVLVMLLPLTYVLSLISA
                     ASHYLAMNMVVVQCIYASLFIITLYALRDRLSNRIIQTAIMTIAYLIIGFGFINWFGQW
                     VLAGRLVGWFAAWVLNNRYIDAIWVDANGPRLTSVFQYANTYAAFLMAFLFAAVFCLMK
                     SKTWYGKGIHGFMLVPIFISLFLTLSRGGLVMLPVVFVLLLLFFKPARQILWILHFAIA
                     GLASFVILSPITSWGLQLIQTYNGAKAAQAWGVLLTTSAVTTLVLWFVQSYLSPRLEKG
                     LQGLASRKLSNLWLPIGAVVITGLFAFLLVGTGLKSLLPANMESRLENINFRQHSVLER
                     ITFYRDASKLIADYPLIGAGGGGWATLYEKYQDYGYTSAQAHNFFMQYLVEVGIIGFVI
                     FMAFILYIFYKYIKGYIKTDDENRDSYFLYLILAMSILLHSLLDFNMSYVFMGILVFVS
                     LGGMAAAMDSKSLKRLSMSASGFRIMYSSVIGILSIVVLFAGLRFLQSANAATYAKRIM
                     AVSTSFEEIQSAINKDLALRPTHPDSVLRLAALYKNVYEQTKKEEFYNAAIEVLNTGLK
                     AEPYNKTMINSKVSLLQMKGENEQAFSILENNISNFNWDNDWYNMLITQAYTIGNKARE
                     QKDTTKEQKYFQAGLAAYQKVLDGVAHIKTVPPEIELTRTFEVTPGIALSTGKIEFMSG
                     KPAEAASILKSGLKDDLSDATNREVARYYIVALQQQGQDDKALYDKLIKADPKEKEQIE
                     QLKALKL"
     misc_feature    complement(17188..17203)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.14"
                     /tool="antismash"
     gene            17275..18213
                     /locus_tag="JYU28_RS14130"
                     /old_locus_tag="JYU28_14165"
     CDS             17275..18213
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: NAD_binding_4 (67-212). E-value:
                     1.6e-11. Score: 35.7. Matches aSDomain:
                     nrpspksdomains_JYU28_RS14130_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018764033.1"
                     /locus_tag="JYU28_RS14130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14165"
                     /product="NAD-dependent epimerase/dehydratase family
                     protein"
                     /protein_id="WP_069010701.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 8.4e-26, bitscore:
                     88.0, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 1.1e-11,
                     bitscore: 41.7, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNIVDLLVKHNHKVAIIDNLSTGKRENINPFA
                     EFFEADIRDTNSLDYIFSNVDPEIVIHHAAQISVQESFRDPYLDAQININGTINILNQC
                     VSHNVRKIIYASSAAVYGVPQYVSINEQHPVSPISFYGISKYAPEEYIKLYSVSYGLKH
                     TILRYANVYGIRQDPKGEGGVISIFLNQLLQKHVPVIYGSGEQTRDFVYVKDIALANLA
                     ALTTAHNEVLNISTDREVTINELYNIIASLLQSSIRPEYRNERTGDILRSALTNQKAAE
                     LLNWIPRHSLEEGLALTLDYYQKELSNGGKN"
     aSDomain        17476..17910
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JYU28_RS14130_NAD_binding_4.1"
                     /evalue="1.60E-11"
                     /label="JYU28_RS14130_NAD_binding_4.1"
                     /locus_tag="JYU28_RS14130"
                     /protein_end="212"
                     /protein_start="67"
                     /score="35.7"
                     /tool="antismash"
                     /translation="EIVIHHAAQISVQESFRDPYLDAQININGTINILNQCVSHNVRKI
                     IYASSAAVYGVPQYVSINEQHPVSPISFYGISKYAPEEYIKLYSVSYGLKHTILRYANV
                     YGIRQDPKGEGGVISIFLNQLLQKHVPVIYGSGEQTRDFVY"
     gene            18197..18991
                     /locus_tag="JYU28_RS14135"
                     /old_locus_tag="JYU28_14170"
     CDS             18197..18991
                     /GO_component="GO:0043190 - ATP-binding cassette (ABC)
                     transporter complex [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013312208.1"
                     /locus_tag="JYU28_RS14135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14170"
                     /product="ABC transporter permease"
                     /protein_id="WP_069010702.1"
                     /transl_table=11
                     /translation="MAARTSIIKPQLKLIFELAKNDFKTRYAGSYLGMFWAFIQPFMTI
                     AVYWFVFEVGFRSGSRPDGTPFILWLTCGMIPWFFFSEALLTSSNSFPEYSYLVKKVSF
                     RIGFLPIVKIISSFFIHLFFLLFLIVILFYFGYNPDIVYIQVFYYLFCLFYLLIGITLI
                     TSSLVVFMKDALQVLGIFVQIGFWLIPIVWSPEIISDKLIKWFKLNPAYYIVEGYRDTF
                     IHHVWFWHRYNQTAYFWILSTFIMLLGIYLFKKLKPHFADVL"
     gene            19007..20281
                     /locus_tag="JYU28_RS14140"
                     /old_locus_tag="JYU28_14175"
     CDS             19007..20281
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015256637.1"
                     /locus_tag="JYU28_RS14140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14175"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_069010703.1"
                     /transl_table=11
                     /translation="MEEVAIELKRIYKKYKLYSKPTDRIKEAVNIFGGSYHTDFFALKD
                     VSLNVKRGETLGIIGKNGSGKSTLLKIITGVLTQTDGDRLVNGQISALLELGTGFNPEY
                     TGIENIYLNGTMRGFSKEEMNSKLEQIIEFADIGEFIHQPVKTYSSGMFARLAFSVMIS
                     FKPEILIVDEALSVGDVFFQQKCNRYMKEEMSDITKLLVTHDLSSIANMADRVIVLSNG
                     EIVFEGDPLKGIEYYTKSVHSEVFKANSETNSLALELNKETSIPLNWIPVNEESLGGAQ
                     EVIIKALDFSVNSEKYKGYISANDLVEIDMLIEAHKTTDELIVGYLVNDKYGNAIFGEN
                     TTGSNIFSGSVTKGKSYLVKLQFRWPEIQENEYFVTLGLGEGFHEMQHTIQCWAHNVIQ
                     LKNIVFTSIHAIFNNKIEHVAIEEL"
     gene            20309..>20947
                     /locus_tag="JYU28_RS26490"
                     /pseudo=""
     CDS             20309..>20947
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_001104034.1"
                     /locus_tag="JYU28_RS26490"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSTPTFESDQINEKLKVAPWEGHRWFAYDYINFIEPNTIVELGTH
                     YGCSFFSFCQAVKDFNLNTKLIAIDTWAGDEQAGYYDEEVYRTVKSTVAAHFSHLNIDL
                     KRMTFDNALSEVNEGTADLIHIDGLHTYEAVKHDFETWLPKLSKDGVIFFHDVFSPLEY
                     GSNVFWSEVKQKYSYLEFKHSWGLGILFPKGDKVYNLLLDQNIEDKINLY"
     misc_feature    complement(21382..21397)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 21.99"
                     /tool="antismash"
     gene            21428..23695
                     /locus_tag="JYU28_RS14150"
                     /old_locus_tag="JYU28_14185"
     CDS             21428..23695
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024811.4"
                     /locus_tag="JYU28_RS14150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_14185"
                     /product="HAD hydrolase-like protein"
                     /protein_id="WP_208332590.1"
                     /sec_met_domain="HAD_2 (E-value: 1.9e-06, bitscore: 25.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MENLIHTVLEKNKKIAFFDVFDTIILRHVEPEYVKKIWAKRVSIY
                     FGDSIDYEELYRLRNNMEAEMCKDNANSGFDMEFNYSNLLSSMYVVLINKGLLNNDIDK
                     DTFISICEKIEIETEMAVQYIDPKWLEVVVQLLKHNIKIYCVSDFYLSQKLIAELFAKH
                     GILQYINEIYVSSEYLLTKKSGKLFTKIVGDNNFNPSDIIMVGDNEHSDYKVPLSQGID
                     AYYIDRKQQHAFYSEFRKRVESETHYANELTAMARDMSHVGRFLEISCSLFFYIVMLHK
                     SLMKNGVKNVFFLSREGEFLLKLFDLYQEKEGYKDTFYVKPHYLKVSRKSTFLPSLLPL
                     DSEKFEILFRQYIHISLYDFLSSLSFEEKVIEEISHKLNIDAKLKIENFPSSKIFTDLR
                     NDSTFIEKYEESRLQQRDNFYSYIENFTVNIKKQGFHLVDVGWKGTIQDNIYRIYNENV
                     SVHGYYLGLIASGDARENNKKQGLLFSSIPYRTPYFNVYNENRALYEIVLGASHGSANK
                     YIRDDYNHRIEVETVQTDMEKKLFDEVISPLQSQIYDFFERLCNLFCNRGVKLEYYTEQ
                     IAKVHSRMVLFPTKAEINFFNGLYHYENFGVFEYSTFNTKNKFDLIKTIKNTFILTRNP
                     RAILEKGFWGPITLSSHGLGYLVPIYGRYKYNKSFKGGSNHQIGTVVSANDRQLVEELK
                     RSLDEKDRTILDLTQMIDDRDEAIKKMTQMIDDRDAAIKSMTQMIDERDEVIEKLSKSK
                     HD"
     misc_feature    complement(24131..24144)
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: strong, score:
                     18.25"
                     /tool="antismash"
ORIGIN
        1 gtaatccggt gtcttttttt tgtgaaagtg agggagacga tattgcgggg ctgtatggcg
       61 ataagaaaca gcctgcttgt atatgggata caagcaggct gttaataggc tctatattta
      121 ggatgcaacg tggctggact gtaaaatggc agacagcttt tcctggaaag tcggaatacc
      181 tacacgctgt acatatgcgt aaaagctttc gccagcgctc ctgttttctt tgtagaacag
      241 aatgagctcc gccagcacag gtccaacctg atccccacgt acgcgacctt tgagcgcctt
      301 gttaaactgg gcgcctgccc caagcgctcc gccgacagcg atgtcgaacg cgtcgaccaa
      361 gccttccggt gtctttatga gcgagccttg cagaccgatg tccgcaatat gcttttgacc
      421 gcaggaattt gggcaaccga taaaatgaat gcgcaccttt tcatccaatt gtacgtgctg
      481 atccaaatac tcggcaacgt caaccgcccg ttttttggtt tccacaatcg ccagattgca
      541 aaactcattt cctgtgcacg ataccgtacg actcataaaa tgcttgggtc gtggtgtcag
      601 gcgttgcagc acgggagctt ccagtagttc atccacttgc tcatccggca cgccgctcag
      661 caaaatattt tgcgacatcg tggtacgaat ctgaccatcg ccatagcggt cagccagttc
      721 ggccagttca tgcaactcgt cagcgctaag gcgaccgaca ggcacgttca gaccgacata
      781 gttcaggcct ttttgggctt gaggatgcac accgtcaaaa taggcggctt gccagccaat
      841 cgttttgtcc tcgcctcttc cgggcatttc accgatatac tcggtgagct tagccagaaa
      901 tttgtctggg ccccaatcga caaccaggaa tttcaagcga gcatggtgcc gcttttcccg
      961 atagccgtaa tcacggaaaa tggtggtgac agcaatagca accttcagca cttcctctgg
     1021 acgaacaaac aaatccagag actgtgccat atgcggcttg gcggacaaac ctccaccaac
     1081 catcacatgg aagccgatca cttcttttcc gtcgaggatc ttggtggccg gagtgaagga
     1141 caggtcgtta atttcagcct gtgcattgtt gtacgtatta ccggagatag acattttgta
     1201 cttacgcggc agattggaga agtctcgatt taataagaaa aaacggttta cttcatctac
     1261 aatctcttgg gtatccacca attcattggg atcaatacca gccagcggat taccgacaat
     1321 ggtacgcggg cagtctccac aggcttcgaa ggaatacaag ttgacttttt ccagtctttc
     1381 aaaaatatcg ggcaagcttt cgactgtcag ccagtggaat tgaatcgcct ggcgagtggt
     1441 gacgtccaca agaccgcgtc cgtatagcgc ggatatgtct gccagtgcat gtgcttgtgc
     1501 tgaagtcatg atccctgtgt tgatgcggac tcgcatcatg aaatgaccat ccttgggctt
     1561 ttgctgatat accccagccc atttgaaacg atccatatcg tccgcagaga tcgagtcata
     1621 gccttcgttg gcatagtttt caataatggt acggataacg tcgagaccgt ccttttccag
     1681 cttgactaac tcgaatttgt taagcttatc gggatgagcg ttccagattg gttcgtaggc
     1741 cattctttta acctcctgta ggtgcttatt tatactttag tgttttggat agaggactca
     1801 tgattttatt ctttatttcc gacaataaaa ctaagatata atgtgatggt atcatagttg
     1861 gttatgcccg taaatgaagg aatgacctaa acggtataac gattatttat cgtttttgct
     1921 tatttttttg atataaggat ttggaaaatt tataatataa atagcatgag aggacaggga
     1981 tgcagcaaac ggcgcctttt agaaaaagat agggcttaaa gcgattgtat acgtgtcccc
     2041 tctatggtag atttggacta actgatagaa cagggtcatg taagagaggg aatggtgagt
     2101 atatgcgtaa gatggggaaa agggcagttg ttctggcttt gggcagcgct ctatgtgttt
     2161 ctggtacggc aggtgcagcc agcagtggga ctgcgttaaa ggccaaagtc attaatggtg
     2221 gggtctatgt taacgtaagc gatatgaata aggcattagg aaccagcggc gcatataaca
     2281 gcgcaaatgg tacatatacg ttatcggccg gtcgtgtgcc gcaggtggtt aaaaatgtat
     2341 ctccttctgt ggtcggtatt attggccgtt cagccacggg agagaccgta gcaggaggag
     2401 atcgatacaa cctggctcac ggcacgggtg tcatcattcg tacagatgga tggattgtga
     2461 cgaatgcgca tgttatcgaa ggattaggtg atgccgtggt cgtaacctcg gacggaaaat
     2521 cttacggaat caccgacagc tatagcgatc cgatcagtga tttggcatta gttaaaatca
     2581 aggcaagcgg cctcaaaccc gctaccttgg cagcttcaac gaacagtcta caggtagggg
     2641 agcaggtagt ggctattggt acgcctatat ccttttcact tcgcaattcg gcaacctcag
     2701 gtgtggttag cgggctgaac cgtggtgtca acgctgctta tcgtttgatc caaagtgata
     2761 ccgcgatcaa tcctggtaac agcggcggtc cgctggtcaa tctcaagggt gaggtcattg
     2821 ggatcaatac gatgaaattc tcggcggtcg gcattgaaaa tatgggcttt tcgattccgg
     2881 cggatacggt gaaatatgtc atcggccaat ttttcaaata cggagaggtt cggcgcgcta
     2941 gtcttggtct agggctggaa gaaagctggt cagctatcgt cggattacct accgaggatc
     3001 ctttgaaagt tacgaaaatt acttcagcca atgccgttca ggccaaaatc aaggaaggcg
     3061 atgagctgta tagtattaac ggtaagcgtg tagcttccgc tattgatgtc aatgaactgc
     3121 ttaaaaacta tcaaccaggt caaacggtga gtgtacttat gcagtctgac ggtgatattg
     3181 tgaagcgcaa gctggtactg acacaggata atggtgaaat ctatgagtcc attcagtctg
     3241 gagaagatag tgaagattcg aacggttcgg aagccgctga agatggtggt gtagcgcctt
     3301 ctaaggaagc atcggagcca gctcaaggag caactactgg aaagtgaaca ataatgcctc
     3361 ttgaatctat aaaataaagc taaagggaga tttactgtga agcatattca aagaaaaatg
     3421 atgcgtaagc tgggggtcgg cgctgtcgca ttgtcccttc tgctttccgc tttgccagca
     3481 gttgcagcag atcatgataa aaccatgctg gaattacggt tgcaaagcgg cagcaataca
     3541 gccatcgtga acggtcataa tgccaatatt acgaagccgt attccaaaag tggtgcactg
     3601 atggttccgg ctggtgtgtt taaaaaggca tttaacagca aaattcgatt agctgaagat
     3661 aatgtggtta aaatcactag cggaactcat gttgtatcgc taaccattgg tagccgtaca
     3721 gcgtgggtga gaggtcacaa ggtgacactt ccagctccac cggaaatgtc atcaggtatt
     3781 ctcatggtgc ctctgcgtca agtagcagaa gggcttggcg gtaagttgga gaagaatggt
     3841 gccggaatca ttattcggat ggaagcacaa gaagaggcag gcacggtagc tgaagagaca
     3901 ccgaacattg ataatgatga gggtaagaca cagatcggga acagttacta tgactggtct
     3961 atgaactatc caacagggct cgtcatcggt cagggaggtg gagatgagag tatttccaca
     4021 tttatggacg agaacagtgc gtattatatg gaagtgcaca cagcgtcaca gccggttcca
     4081 ctgaatgcgg acgatctgct gcaacaattg gtgcaggcag ccaaggaaac gggagaaact
     4141 gtgatcgatc gaaaatcctt cccgaaagcg aaggtacctt atgctcgtgt cattacgaag
     4201 gatggggacg gcgtgctgtg ggaaaatcgt cagtactatg acaacggacg attgtatgta
     4261 gtttattttt ccgatgctaa agcaacgaat tataaagatc tggcccagta tgcgggactt
     4321 ttaaattcct tcaagacctc ctttaatgcg caggataaaa gtattaaaga cttgtctact
     4381 gtcgtaggag gcacacgcga ggccgggaat ccagactacg gtgtgtcact cagcataccc
     4441 gcaggctgga aaatggacga tcaacggatg caatatgaaa gtaatgatgg atcgagcttc
     4501 cgtgtgaaag taacctcagc tccagcagat ggaaaattgg agaactgggg ccagcagctg
     4561 caaaaatggc tgagcgattc atttgtgtcc acggcttatg aggcacagaa gacgtatccg
     4621 ctggaggttg caggcgttca agggttagta caggagtacc gctataattt tggcgatgga
     4681 tgggtcaaag agtacaatgt gctgattcag caaaatggat accgctactt ggctgaatac
     4741 gcagtgcctg aaaaagtaag caaaggaaat gatcagttca acgcgctcat ttcctcgctt
     4801 caaatcgatt ttcaaaccgt agcgagtaac tttggacagt tggaagaaga cgactatttg
     4861 acagacaaaa cgaaaacggt caaaaagacg tcaaaagcct atgagtatac agtgaatatc
     4921 ccacgatatt ggaccgcgat tagcgatcaa tttgaattgg gcgatgtaga gtaccagttt
     4981 accggaggac gtttttccat caaaatcgac aacgaccaat catttgaact aacggtatcc
     5041 cagctcaagg acttctacga taagcaagca aagaactaca aaaacctcaa agttgaggag
     5101 gttaaggacg taacatttgc tggtgttccg gcagtgtcct ttacattcca tcgtatcgag
     5161 gaaggcattg gctacacagg ccaccaattg gttttagaac gtgacggaaa aacgtatacc
     5221 gtgacaacga cattgaatga tgcgaacaac acggctattc agtctaacgc actggattcg
     5281 acgttaaatt cgtttaattt tgtgaagtaa gagggtgtag gtaagagatt agcgagttat
     5341 ggtgagagcg ctacgcgtgc cttttgatcc tacgatcgct gttgacccgg gattcttgga
     5401 ttgtataagg atttaatatg taagaatccc gggtcaaagg cgaacgctga cgcttctacg
     5461 gattcaaatg gcccgcttcg ctggcgcccg ccaaatacca ccaatctttt gatgagtgag
     5521 gtaagcaggg aagagcgaag gcagatattt acggtactta gatcagcgaa cgcgaacgcc
     5581 ttttttcgga ttcattgtcg agtacgctgg taccgcacaa ggctgccgtt ttctaaaagg
     5641 gcgaggtaag gcttaatagc gcgtctaagt tgccagtctt catctccatt tggcttcctt
     5701 tactacgttg ttcctcttgt tctataggat tcttcacctc caaagttccg tttgacggaa
     5761 ttggaggtgt ttttgtatgg tttggtaaga gttttttacg aggaatcgct tggaaagtgt
     5821 agaagcttgg gacgcagtct ggtacactag attagttaca agataagaat aactatgccg
     5881 caaatgttcg tgatgcggat tttttgagtt ggatgccatt tatccctcga gccagtggtt
     5941 cagagtgggg atgatcggat aggatgataa ttcatagggc tataaaataa gcagcatcgc
     6001 tgctctggaa aataacttta actcaaggtt aatcagttat ttctccatat agggaggaca
     6061 aaaatgaaat cagtagtacg aagagaagat gttgagcttc tggcaccagc cggtgactgg
     6121 gattgtatgc gtgcggcggt ggcaaacggg gctgatgcga tctttttcgg ggtggaaaag
     6181 ttcaacgcac gggcacgggc gaataatttc cgcatggagg aactgcctga aattatggcg
     6241 tttttgcata gctatggggt taaaggtttt ttaacattca atatattggt atttgaaaac
     6301 gagttggagg acgctaagga gctggtcgat gcctgtattg atgctggagt cgatgcttta
     6361 attgtccagg atatgggcct ggtgaaaatg atccgcgaca tttcaccgga ttttccgatt
     6421 catggttcta cccaaatgac gattacctcg ccggaagcgg tagagtttac aaagccgtac
     6481 aatatggaac gggtcgtgct tggacgtgaa aacaacctga aacagatcca aaaaataggc
     6541 gatcaggcga gacttccaat ggaggtattc gtacatggag cattatgcgt atcttattct
     6601 ggccaatgcc tgacttcaga aatgtggggc ggccgctctg ctaaccgtgg tgagtgtgca
     6661 caggcatgtc gtttgcctta cgatctgatg gtggatggag agcagaagcc aatggcagat
     6721 gtgacgtatc tgctgtcacc taaggatcta gcagcgattg acctgatgcc tgaactgatc
     6781 gacgcgggtg tggtttcttt taaaattgaa gggcgactga aaacacctga atatgtggca
     6841 aatgtggtca gcaagtaccg caaggccatt gataagtatt ttgatggcga tacgtccaag
     6901 acgagcaaag aagatatccg cgagctgcag cagagctttt cacgcggctt tacgcacggt
     6961 tttctcgaag gaaccaataa caagaagctg gttgacggga cgttcccgaa aagccggggg
     7021 gtgtatctgg gccgagtgga acaaatcctt cgtgatggcg tagtgtgccg tattgatgca
     7081 ccgctcaagc gtggcgatgg tattgtattc gatgcgggag atcccacgca aaaagaagaa
     7141 ggcggacgcg tatacgatat ccgtcgcaag ggcgtgaaga ttgaaggcga agccggagaa
     7201 ggctggatca ttgacatcgt agcgggacgc aacgatgttg atctgcgccg tgtacacgtg
     7261 ggcgatcgca tttggaagac caacgacccg gcgctggaca agcgtctgcg ccagtcgtac
     7321 gacacggaca agccgtaccg ggtcttccca gtacatgtgc gggtcagcgg ctccccagga
     7381 caaccgctgt cgacatggtg gaccgacgtg cagaaaggca caacggtccg cgtggactcc
     7441 gagctggaac ttgaaattgc ccagaagcgt ccgatgacgc acgagctgct cgaagagcag
     7501 ttcggccgac tgggcggaac ggtgttccag ctggaagagc tggacgtcca tctgcatggg
     7561 gacgtcatcg tgccgatgcg cgagctgaat ggtatccgcc gtcaggcggt ggaactgctc
     7621 gcgggcgagc gccccaaacc gcccgtgtac acgaagcggg cggtcgaggt gtatgacgat
     7681 gcatcgactc cggcatcgtc tgtggcacgc ggtcaggcag agctgaccgc gttgtgccgc
     7741 agcctccctc aggtggaggc tgcgctcgag gccggcgtgg agttcatcta cgccgacttc
     7801 gagttcatca agcaattccc ggcagccgta gaggcagtgc acgctgcagg ccgccgaatt
     7861 gcgctggcga ccccgcgtat tcacatgccg ggtgaaaatg gctatcacaa caacatcctg
     7921 cgcctaaagc cggatgctgt gctggtacgc aatccagggg cactgtattt ctacttgcga
     7981 catcggttgg agaacccgga cgcacatcac ccgcaattga ttggtgactt ctcgctgaac
     8041 atagccaatc ataaagcggc tgatctgttc ttggattctg gctgcgacct ggttacgccg
     8101 tcgtacgatc tgaacatcca gcaaatggtc gatatgctca gacgtacgcg taccgataag
     8161 ctggagatcg tgatccagca gcatatgcca atgttccata ctgaacattg cgtatactgt
     8221 acctttatga gtgaaggcac cgactacacg aactgtggac gtccgtgtga ggaccatcgc
     8281 gcatccctgc gtgatcgaat tggtatgtct catccggtcc gtgtggacga aggctgccgc
     8341 aacacggtat acaacgcgat tgagcaatct ggcgcggagt acctgtccaa cttcctggag
     8401 ctgggcgtgt cccgttaccg tgtggaattt ttggaggaga caccggagca agtgcatgag
     8461 gttattgatc tctataaccg tgccctgcgc ggagaaatca gcggaacaca agtatggaag
     8521 acgctgaaag cgacgaatca gttgggtgtt acacgtggtc agctggtgaa gtaaataact
     8581 gtatatttgt tcgggagcca gaaagattcc ggcagcataa tatatttata tagaaagcta
     8641 gtgattggaa gacatgttct ctttgaggga agatgtcttc ttctttaatc tattacaata
     8701 attgaccttc ctgttataat catagacagt atatcttacc gttatattga tgacaaagga
     8761 gtttaaccta tgaaaatccg taaagcgatt attcctgctg cgggattagg aacccggttc
     8821 cttcctgcta cgaaagcgat gcctaaagag atgcttccca ttgtagacaa accaacaatt
     8881 caatatatta ttgaagaagc tgttgcatct ggtatagagg atatcattat cgttactggt
     8941 aaaggcaaaa gggcgattga ggatcatttt gactactcct ttgagctgga gcataatttg
     9001 actgcgaagg aaaaatggaa cctgctcaat gaagtgcgta aaccatcaga gatggcagat
     9061 atccactata ttcgtcaaaa ggaacctaaa gggttggggc atgccatatg gtgtgcacgt
     9121 aagtttatcg gtgacgaacc ttttgccgtc cttttagggg atgacatcgt tgagtctgag
     9181 aatccatgcc tcaaacagat gattgacgtg ttcgatgagt atcagcgttc tgttgtaggt
     9241 gtaaaacaag taaattggaa cgaggtacat cgttacggga tagttgaagg ccatgcactt
     9301 acttccaaaa tctctgaggc ggaacgattg gtagaaaagc caaagaagga agaaaccaac
     9361 tccaacttgg cgattatggg acgttatatc ttgacgcctg atatttttga tatcctgggt
     9421 cagcaatctg cgggagtagg cggggagatt caactgacgg acgcattgtc caaactggga
     9481 gaaaagagcc ccattctggc ctacgaattt gatggcaatc gccacgatgt tggcgagaaa
     9541 ttgggattca ttgaaacgac cattcattat gctctacagc ataacgagat aaaggatgaa
     9601 gtactggctt atatgagaca ggttattgaa gggattgatg aaaatataac aaaattgtaa
     9661 ttgtatgcga taaaaagaag ttttggattt tttagttctt cttttaaaat gagagagtaa
     9721 tattccaaat aatctcttat tctatcgaag gaggaacaaa gatgaactct ttagaactat
     9781 tcgttttgga acaagaagac actcttgatt tggacttaca ggttaatgct ttctcatctg
     9841 aaccggttac tatggcatgt actggtactg ttacttgtgc tgtctctgct tgctacgata
     9901 cttatgtaac ttgtaactgc tgttaattgt gttaaaacta accccagata tgctttgtat
     9961 atctggggtt ttcttatgta aagaaggagg gctactagct atgaagggta taagacacag
    10021 gaatgaaaat aggaatttgt ttagagcgtt agattttttt ttggttagaa ttccgttgtt
    10081 gcctgtagag atgtacaatg aactatttta tgagccttca tatgaaaatt tacgtaacaa
    10141 gttgcttcat atggtaaaag agccaattgt ctgcgaagcg cttttaattg caagtccctc
    10201 attaatgcac tctgttaatc aaatactgga caattcaaat tcaaagaaag cagataaaat
    10261 tatcaaagca atagctcatt atatgattag gctttcaaca cgcgctaccc cttacggtgt
    10321 ttttgctgga gttgccatgg gttcttttga aagtgaaagc aggctggtaa taggagactt
    10381 gagctttcat cgaaaaatag cacgcccaga tatgcaatgg ttaatggatc ttgtaaaggg
    10441 tttggaacgt ataaggcacg tcgttgaaca agtcgaagtt cgtacgaact cgatcctcta
    10501 tacttccggc tcacgtgtga agttacctta tctcaattat atagatcatt ttgattcctc
    10561 tgatgaaatg aaaagtagct caatccgaat ttctaaattt gtagactatg ttattcactg
    10621 cgcgaaacag cccgttccta tcttaaagct aatggacaaa atgaaagaag agttcccgac
    10681 tataaatcaa gagcaactat ttggtttgtt attgaagtta gtagaacaag agtttttaat
    10741 aagtaattta agacccccct tatccatacg taattctgaa ttgccatttg aatatataaa
    10801 agggcaactc gcatccatga caggcataga cgatctcaaa gcctcaattc agaagattta
    10861 taactacatt cagcaatata atcaaacctc tgtaggtgag ggggaagagc tatatacgaa
    10921 catatgcagc agcatcaatg aaatgttccc cagcaaagat ccgcttcaaa ttgacatgga
    10981 aacagctata acaaacgcga ctttaagtca cgaaatagcg gaagaggtcg caatagcggc
    11041 cgaagtctta tggagactat cgaataatgt atgcaatccg catcttgcga cctatcgagg
    11101 cgcctttatt gagaagtacg gagtacatcg tcagattccc ttgttagaac tgttggatga
    11161 agatatggga ttaggagccc ctcctgatta taaatatcct atgagcaaac gtagctggga
    11221 aaagtctact gcgaatgcag acagagataa acatttagca cgctgggttg cagaagctat
    11281 caaacaaggt agtatcgaaa ttgagcttac agatgaaaaa atcagaaaaa tagaatgtgc
    11341 cccttcggag ctttctcctc caccatcact ggagatgtac gttaccgtcg ccacttcgga
    11401 tgccaccgct ctcgaaggtg gggactataa attgattgtt aaccccaatt caggcggcac
    11461 aggtgcaggt aaaacatttg ggagattcgg tccgattcta gatggttctg cacaaaaaca
    11521 aatctccagt atttataaaa tacagtcaga tcaaaatcca aatgtgattt ttgcggagct
    11581 tatctatctt acgattaata gtagacattc caacgttgtg ataacgaatc gttcctgttc
    11641 tcatcagatt atccttggga ccaatgatta tacagatgac cgtgcgtcta ctatttcttt
    11701 agccgattta tatgtaggtt gtacccatga ctctttttat ctaatgtcac gctctttgaa
    11761 taaaagggta atcccggtag ccacaaatat gttgaattac tacaaagcgc cgaatgttta
    11821 tcgatttttg cgtgaaatgg agcaggaagg acagaggaat gtttcaatgt ttcagtgggg
    11881 gaatcactta tcagagttgc cttttcttcc ccgcataaga tacggcaata ccattctgtc
    11941 attagcgtcg tggtctttaa atgcagatat gaaggctttc cagaattgtc ataccaagag
    12001 tgattggcgc aatgcatttg aaaggctgaa aaaagaatgg agtattccga gatacgtgta
    12061 tataactatt gcagataaca gattgttaat tgacactaca catgattttt gcatatccga
    12121 actatatgat aaatatcaaa agcttacaga ttcagcctcc atatggttga ctgaatgcgg
    12181 ttttgagtgg agtgaagtat ggggagagtc cacgaaagga caccacattg cagagtatgt
    12241 cattcctttg gtgaaaacga ataaagtagg ccaatcgaga tcaaaggacc ttattcaacc
    12301 agatatgatg caaaacccta tcagtacccg ttcgatggat gtttattttc caggcagtga
    12361 atggctgtac gttaaattat atggtatgtc tgaacggaag gaggagttta ttggaaatta
    12421 tctcagacct ttttgtgaac tggcagaaaa acaaaaaata gtcgatcaac attttattat
    12481 tcgatataaa gatcctgatg atcatgtacg agtgagattt catggggatg cagcgatgtt
    12541 gtgtgcgcaa ctgattcctg ctattcagac gtgggcgaac aagcttaaga aggaaggact
    12601 gctaaaccaa cttgtgtatg atacatacga gcaagaggtg gaaagatatg gggggggaag
    12661 cttcattcaa ctggctgagg aagtttttgc tgcagattcc aagctcgctt ctgaattcat
    12721 ttatttgcac tacaacaaaa aatggaatat gccattagaa gacattgcat tgattagtgt
    12781 gattgatatg ttaaatcaat ggatgccttc actagctaag caggttgaat ggtcccaaca
    12841 gaaagagtgg cataaccatc atatcaaaga gttccaaaag aatcgtacat ggtacatgtc
    12901 gatatgcgat gtttccgatc gatggagttc attgagagct tgtaattatg gtgagtttat
    12961 gatagaacgc tttcaacctc gaagggaaaa actgaaacaa tataaggaga ggttctttca
    13021 gaaaaaaaag gaaacatgct gggacggacc tttattggat attatggaaa gttttattca
    13081 catgcatctg aacagattac taggcacgga tcgaatgaag gaggcgaaaa taatgtcact
    13141 attaagccac gctctttatc atctaaacca tgctcagaag tatacaaagc gaatgaatta
    13201 taaggagtgc tgaggcatga ttacaacggg aatatcagaa gatttgcgtc agactatttt
    13261 ggagattgta catgaggttg gaagaagatt ggcagattcg gattacgtaa cggcaatgtg
    13321 ctcatcggac tcgaatcgaa cagatttaca attggattac aaatgggatg agattagtct
    13381 tgcgagtggc tatccagcgg tgagtctact atacggaagg ctgggtactg tattccgcga
    13441 ggagacgttt acccgatacg cacatcagta tcttgtgaat acaagagaag cactcaagct
    13501 gaaggaaaac atatctttat cgctgtggag cgggctatcg ggtattggat ttacggccta
    13561 cgcactgtct gacaatctgc gcaaataccg aagttttatt gaacagatca atcatttaat
    13621 ccttcgttat ggtgctgctc tgttggaaag ttcaagaaat aatctaaaag cgggagtcat
    13681 ttttcatgac tatgatgtta tttcgggatg gagtgggata ggtagatacc tgttattgtt
    13741 caaagatgtg cctgagatga gagatctcct taaagatgtt cttgaatatc ttgtcatgtt
    13801 aagtgaagag agggcttgga atggtgaagt tctaccaggc tggtatatcc ccgttcacaa
    13861 tctgccccca catgagcagc agaggtatcc tgaaggatac ttcaacatgg ggttggctca
    13921 tggaattcct ggaccgttgg ccttactatc aatagcttgg catcacgatg tgagagtgtc
    13981 aggacataaa aaggcaatag aacgcttcgg ttcatggttg agtcattgga agcaacagaa
    14041 tgattttggg tggtattggc ccaataatat aagctataga gaatatatga atggaattat
    14101 tttcgatgaa acagaacgtg aagcctggtg ttatggaact ccaggggttg ccaggagctt
    14161 atggctagca gggagggctc tggagaacga aaaattagag gcgctcgctg tggatgcttt
    14221 caaatccata tacgcacgtc cccgtgaacg ttggagcata tattctccat cggtatgtca
    14281 tggatattcg ggattaataa agctcacgca tcagatgtat ctggatacgg gagatgccga
    14341 gttgcgtgat tatgctcagg gcttgctttt agaagtcgtt aacatgttcg atagaggggc
    14401 agcattcggt ttttgggata tcgtaaagga tactcaatcg gtcaaacatt tggatttcgt
    14461 aggcgtattg gatggggttg caggcattgt tatgacttta ctagatactc tagagtccga
    14521 ggaaagtatt tggggaagaa gcttattaat cacatagcgg aaggaagtaa aacttaggat
    14581 ataaaggaag gaacgctaga agtgaaaaac ttctgcgttc cttttttggt gggtgcattt
    14641 ttgtatttgc gttcaatgtt aaacgtatac ctagagcttt aaggccttta actgctcaat
    14701 ttgctctttt tccttcggat cagccttaat cagcttatcg tacaaagctt tgtcatcttg
    14761 tccctgctgt tgcagagcga cgatataata gcgagcgacc tcacgatttg tagcatcact
    14821 caggtcgtct ttcaagccgc ttttgaggat gcttgcagcc tcagcaggct tacctgacat
    14881 gaactctatt ttaccagtac tgagcgcaat acctggagtc acttcaaaag tacgtgtcaa
    14941 ctcaatttca ggtggaaccg tcttaatatg agctacccca tccagaacct tctgataagc
    15001 agcaagacct gcttggaaat acttctgttc tttggtggtg tctttttgct cacgtgcctt
    15061 attaccaatg gtgtaagctt gggtaatcaa catattgtac cagtcattgt cccagttaaa
    15121 gttggaaatg ttattttcca aaatactaaa ggcttgctca ttctcgcctt tcatttgtaa
    15181 gagggaaact ttagagttga tcatagtttt gttatacggc tctgctttca aacccgtatt
    15241 tagcacctct attgcagcat tataaaattc ttcttttttc gtttgctcat aaacattctt
    15301 atacagtgca gccagtctca gaacagaatc cgggtgtgta ggacgaagtg caagatcttt
    15361 attaatagca ctttggattt cttcaaatga tgtgctgacc gccatgatcc gtttagcata
    15421 tgtggcagca ttagccgatt gcaagaagcg gagacctgca aaaagcacca cgatgcttag
    15481 aatgccaatg actgaactat acataattcg gaatccggaa gcactcattg acaggcgttt
    15541 aagcgacttg ctgtccatag cagcggccat accaccaaga ctcacaaata ctagtatgcc
    15601 catgaacaca taactcatat taaagtccaa tagactatgg agcaaaatgg acatcgccaa
    15661 aatcaggtat aggaagtagc tatctcggtt ttcatcgtcg gttttgatgt aacctttaat
    15721 atatttataa aaaatataaa ggataaacgc cataaaaata acgaatccaa tgataccaac
    15781 ctctaccaga tactgcatga agaagttatg agcttgtgcg cttgtgtagc catagtcttg
    15841 atatttttca tacagcgtag cccaaccgcc accacctgca ccaatcaacg gatagtcagc
    15901 aattagtttg gaagcatcgc gataaaaggt tatacgttcc agtacactat gctgtcggaa
    15961 gttgatattt tccagacgtg actccatgtt agctggaaga agggatttca gtcccgtgcc
    16021 aaccagcagg aacgcgaaaa gtccagtaat taccacagct cctataggta gccacagatt
    16081 agacagtttg cgtgaagcca gaccttgaag acccttttct agacgcggac tcagatagct
    16141 ttgtacgaac cataaaacaa gagtagtcac ggcagaagtg gtaaggagta ccccccaggc
    16201 ttgagcagct tttgcaccgt tgtaggtttg aataagttgt aatccccagc tagtaatcgg
    16261 gcttaaaata acaaaagagg ccaaacctgc tatagcgaaa tgcaaaatcc ataaaatttg
    16321 tcgtgcaggt ttaaaaaaca aaagtaacag gacaaatact acgggcagca ttacgagacc
    16381 accacgtgag agagttagga acaacgatat aaaaataggt accaacataa agccgtgaat
    16441 cccttttcca taccatgtct ttgacttcat cagacaaaag acagccgcaa acaaaaacgc
    16501 catcaaaaac gccgcgtatg tattcgcgta ctggaagaca gatgtgagac gtggaccgtt
    16561 agcatctacc catatcgcat caatgtaacg attgttaagt acccaagcag cgaaccaacc
    16621 caccaagcgt ccagccaata cccactgccc gaaccagtta atgaacccaa agcctataat
    16681 aaggtaggct atggtcataa tggccgtctg gatgatgcgg ttgctcaacc gatcccgtaa
    16741 ggcgtacaat gtaatgatga ataatgaggc atagatgcac tgcacaacta ccatattcat
    16801 cgcgagataa tgagaagcag cggaaatcaa tgatagtacg tacgtcaacg ggagtaacat
    16861 aacaagtact gccagccagt ctctttgatc ttccaatttg aatttcttat aataggttgc
    16921 gattcccaaa atcaatagaa tcatgctgat gatcaaagca caataaagtg gcttctcaaa
    16981 ttcgagcatt tgcccattaa atagtgcagc ctggaaggga gaccaagcta aaaacagaat
    17041 catgccaaca attaacaccc aaaacatagc cggcctttta tcgtcatggg tcgacgtttt
    17101 ggcctgtttc ccgtatactg gattcgacaa ggtttacaat ctccttttct tgtagatacg
    17161 tcaacatttt agcatagaga aaatgagtta accagttgtt caaagtactt ttgtaattat
    17221 attcaaaaag ataaacttat ttgtagtata tattcgaaaa aaaggagaag ttttatgaaa
    17281 gttatagtaa ctggaggagc aggatttatt ggctctaaca tcgtggattt acttgtaaaa
    17341 cacaatcata aggttgcaat tattgataac ctttctacag gtaagcgaga aaatataaat
    17401 ccttttgctg aattcttcga agctgatatt cgtgatacta atagtttgga ctatattttt
    17461 tcaaatgtag atccagaaat tgtaattcat cacgctgctc aaataagtgt gcaagaatca
    17521 tttagagatc cgtacttaga tgcacaaata aatataaacg ggacaattaa tattttaaat
    17581 caatgtgttt ctcacaatgt taggaaaatt atatatgcct cttctgctgc agtatacgga
    17641 gtgcctcaat atgtaagtat taacgagcaa catcctgttt ctcccatttc tttttatggg
    17701 atttctaagt atgcacctga agagtatata aaactgtatt ctgtttctta tggcttaaag
    17761 cacacaattt tacggtatgc aaatgtatat gggataagac aggaccctaa aggtgaaggt
    17821 ggagtcattt caattttctt gaatcagttg ctacagaagc acgtacctgt gatatatgga
    17881 agtggagagc aaactaggga ttttgtctac gttaaggata tcgctttggc aaacctagct
    17941 gctttaacta cagcccacaa tgaagtttta aatataagta ctgatagaga agtaacaata
    18001 aatgaacttt ataatataat agcttcttta ttacagtcca gtatccgacc tgaatatcgt
    18061 aatgaaagaa cgggtgatat tctgaggagt gctttgacta accaaaaagc ggctgaactt
    18121 ttgaattgga tcccgagaca tagtttggaa gaagggctag cattaacctt ggattactat
    18181 cagaaggagt tatcaaatgg cggcaagaac tagcattatt aaacctcaac taaaacttat
    18241 ttttgagcta gctaaaaatg attttaaaac tagatatgca ggatcctatc ttgggatgtt
    18301 ttgggctttt attcaacctt tcatgactat agcagtgtac tggttcgtct ttgaagttgg
    18361 atttcgttct ggtagtagac ccgatgggac cccgtttatt ttatggctca cttgtggaat
    18421 gattccgtgg ttcttttttt cagaagctct acttacttct tcaaatagtt ttccagagta
    18481 tagttattta gtaaagaagg tctcgttccg tattggcttt cttccgattg ttaagataat
    18541 atcttcgttt tttattcatt tattcttttt gttgtttctt attgttatac ttttttattt
    18601 tggttataac ccagatattg tttatataca ggtattttat tatctgtttt gtttatttta
    18661 tttattaatt ggaataacgc ttattacgtc ttctctagtt gtttttatga aagacgcatt
    18721 gcaagttttg gggattttcg ttcagattgg attttggttg attccgattg tgtggtcacc
    18781 tgaaattatc tcagataagc tcattaaatg gtttaagctt aatccggcat actacattgt
    18841 tgagggttat cgcgatactt ttatacatca tgtttggttt tggcaccgat ataatcaaac
    18901 tgcatatttc tggattcttt ctacatttat catgctttta ggcatatatt tatttaaaaa
    18961 gttaaagcct cattttgcgg atgtgctata agttgtggag gttattatgg aagaagtagc
    19021 tatagaatta aaaagaatat ataaaaagta taagttgtat tcaaaaccga ctgacaggat
    19081 taaggaagct gtgaatattt ttggtggatc ctatcatact gatttttttg ctttgaaaga
    19141 tgtatctctg aacgttaaga ggggggagac actaggtatc ataggtaaga atggttctgg
    19201 taagtccact cttttgaaaa taattactgg ggttttgaca caaactgatg gtgatagact
    19261 ggttaatggt cagatttcag cacttttaga gcttggaact ggatttaacc ctgaatatac
    19321 tgggatagag aacatttatc taaatggaac aatgcgtggc ttttcgaaag aagaaatgaa
    19381 tagtaaattg gaacagatta ttgagtttgc tgatattggg gagtttatcc accaaccggt
    19441 taagacatac tcaagtggta tgtttgcccg attagcattt tcagtaatga tcagttttaa
    19501 gccagagatt ctcatagttg acgaagcatt atcagtagga gatgtttttt ttcagcagaa
    19561 atgcaatcga tatatgaaag aggaaatgtc agatatcaca aaattgctcg tgacacatga
    19621 tctcagttct attgctaata tggcagatag agttattgtt ctttcaaatg gggagattgt
    19681 atttgagggg gatcccttga aagggattga atactatact aaatccgtac attctgaggt
    19741 gtttaaagct aactcggaga caaattccct cgctttggaa ttgaataaag aaacaagtat
    19801 tcctttaaac tggatacctg ttaatgaaga gtcattaggt ggagcacaag aagtcataat
    19861 caaagctttg gacttcagtg tgaatagcga aaagtataaa ggatatattt cagcgaatga
    19921 tctagttgag attgatatgt tgatagaagc tcataaaaca acagatgaat tgatcgttgg
    19981 ttatcttgtg aatgataagt atggaaatgc tatttttgga gaaaatacaa ccggttcaaa
    20041 tatattttca ggttctgtaa caaaaggtaa gtcttatctt gtcaagttac agtttagatg
    20101 gcctgagatt caagaaaacg agtatttcgt gactcttggt ttaggtgagg ggtttcatga
    20161 gatgcaacat actatacaat gctgggccca taatgtcatt caactcaaaa atattgtatt
    20221 cacttcaatc catgcgatct ttaataataa aattgagcat gttgcaattg aagaattata
    20281 aggagagatc gatttgaata aatgggatat tagcacgcca acattcgaat ccgaccagat
    20341 caacgagaag ttgaaagtgg ccccatggga aggtcatcgt tggtttgcat acgattatat
    20401 taactttatt gaaccaaata caattgtaga gctgggaacc cattatggat gttcattttt
    20461 ttcattctgt caggctgtta aggatttcaa cttaaacaca aagcttattg ctatagatac
    20521 ttgggctgga gatgagcagg ctgggtatta tgacgaagaa gtataccgta ctgtgaaaag
    20581 tacagtagcg gctcatttta gtcatttaaa tattgacttg aaaaggatga cgtttgataa
    20641 tgcattatct gaagtgaatg agggcacagc tgatttaatc cacatagatg gtctacacac
    20701 ctatgaagcg gtgaagcatg attttgagac atggctacct aagttgtcta aagacggtgt
    20761 tatcttcttt catgatgttt ttagtcctct tgagtatggt tcaaatgttt tctggagtga
    20821 ggtaaagcaa aaatattctt acttggagtt taaacacagt tgggggttgg ggattctatt
    20881 tcctaaggga gataaagtat ataatttatt acttgatcaa aatattgagg acaagataaa
    20941 tctgtatact tataaggctc tatattcatt tgagcaaata aaaacaaatg atctctcttt
    21001 gatggttgaa gaacgtgata aaataataaa cgacaactca cggatgattg ctgaaaggga
    21061 tgaggcaata aaaagcaatg ggatgatgat atccgaacgt gataaaacga ttagaagtaa
    21121 tgaaattatg atatccgaac gtgatgaagt cataaagaag aatgagagtt tgatttatga
    21181 acgggatgtt gccctggaag cgactgaaag tttggtgaag gaacgggatc aattaatacg
    21241 caatatggaa aagatgattg aggaaagaga acagttatgt aatcagtacc aaaatgaaat
    21301 tcaaaactta agggcgaata ttgtggactt gtataagaga attgagctct tagaaactaa
    21361 agttaactat tacgaaagta agaaaataat ttttaatttc agaaacaaag cggattaagg
    21421 agcctacatg gaaaatttaa ttcatacggt actggaaaaa aataaaaaaa tagctttctt
    21481 tgatgtgttt gatacaataa ttctccgtca tgtagaaccg gaatatgtga agaaaatatg
    21541 ggctaaacga gttagcattt attttggcga ttcaattgat tatgaagaat tatatagatt
    21601 gagaaataat atggaagccg aaatgtgtaa agataatgca aattcaggtt ttgacatgga
    21661 atttaactac tccaatttgc tatcctcgat gtatgtagtt ctgattaata aaggactttt
    21721 gaacaatgat atcgataagg atacatttat ttctatatgt gaaaaaattg aaattgaaac
    21781 agaaatggca gttcaataca ttgatccaaa atggctcgaa gtagtagttc agttacttaa
    21841 gcacaatatt aaaatttatt gtgtttcgga tttttatctc tcgcaaaagt taatagctga
    21901 gttatttgct aaacatggaa ttcttcagta cattaatgag atttatgtat ccagtgagta
    21961 tttgctgact aagaaaagcg gtaaactatt cacaaaaata gttggtgata ataacttcaa
    22021 tccctcagac attattatgg taggcgataa tgaacactca gattacaaag tgcctctttc
    22081 tcaggggatt gatgcttatt atatagatag gaaacaacag catgctttct atagtgaatt
    22141 tcgtaagcgg gttgagagcg agactcatta tgctaatgag ttaaccgcga tggcaaggga
    22201 tatgtcacat gtggggagat ttctagaaat atcctgttct ttgttttttt atatcgttat
    22261 gcttcacaaa tctctaatga aaaatggcgt gaaaaatgta ttctttttgt caagagaagg
    22321 agaatttctg ttaaagttat ttgacctata tcaggaaaaa gagggataca aagatacttt
    22381 ttatgttaag cctcattact tgaaagtatc tagaaaatct acatttttac cgagcttact
    22441 gcctcttgac agtgaaaagt ttgagatttt gtttagacaa tatattcata tttcgttata
    22501 cgattttttg tcaagtttaa gttttgagga aaaagtaata gaagaaattt ctcataaact
    22561 taatatagat gccaagttga aaattgaaaa tttccctagt agcaagattt ttacggattt
    22621 aagaaatgat tcgacgttta ttgaaaaata tgaagaatca aggcttcagc aacgagataa
    22681 tttttacagt tatatagaaa atttcactgt gaatataaaa aaacagggct ttcatttagt
    22741 tgatgtgggt tggaagggca ctatacaaga taatatatat agaatataca atgaaaatgt
    22801 atcagtacat ggatactatt tagggttaat tgcctcagga gatgctcgag aaaataataa
    22861 aaagcaggga ctcctattct cttctattcc ttatagaact ccttatttta atgtatacaa
    22921 tgaaaacaga gcattatacg aaatagtgtt gggtgcttct catggaagtg ctaataaata
    22981 tattcgtgat gattataatc ataggattga agtcgaaacc gtccaaacag atatggaaaa
    23041 gaaattattc gatgaggtaa taagcccatt acagagccaa atatatgatt tttttgagag
    23101 attgtgtaat ctcttctgca atagaggtgt aaaacttgaa tattacactg aacaaattgc
    23161 taaagttcat tctagaatgg tcttatttcc aacaaaagcg gagataaatt tctttaatgg
    23221 tctgtatcat tatgagaatt ttggggtatt cgagtattct acttttaata caaaaaataa
    23281 gtttgactta atcaaaacga ttaaaaatac ttttatattg acacgaaacc cgagagctat
    23341 tcttgaaaag ggcttttggg ggccaataac acttagtagt catggacttg gctatttagt
    23401 gcctatttat ggacgttaca aatataataa aagttttaaa ggtgggagta atcatcaaat
    23461 tggcacggtc gtttccgcaa acgataggca gcttgtggaa gagcttaaaa ggtcattgga
    23521 tgaaaaggat aggaccattt tagacctgac gcaaatgata gatgatcgag atgaagcaat
    23581 aaaaaaaatg acacaaatga tagatgatcg agatgctgct attaaaagta tgacacaaat
    23641 gattgatgaa agagatgagg ttatagaaaa gttatcaaaa tcaaaacatg attaggggaa
    23701 gaagaaaatg aaatgggctt tcttattagg atctcctgat attagtggag gttcgtatgt
    23761 aatttttgaa catgcaataa aagcaacaaa aaaaggtgta cttgtaacaa ttattactga
    23821 agaaaaaatt aatatggaga gattacattg gcatcctgaa gctaggtctt taatttggaa
    23881 aacatacaaa gaagtcgaaa atgataaatt tgatgtatgt attgcaactt ggtggagaac
    23941 tgtttacgaa ctatatcgag tgaccgcaga aacatatgct tattttgttc agtctattga
    24001 atcaagattt tatgatgaga atgagagatc actacggcat ttggtagact ctacctatca
    24061 gcttcccttg cacataatta ccgaagcaaa atggatacaa aagcatttaa atgaacactt
    24121 taataaagat gcaaaattag tgcccaatgg tattagaaaa gatatttatt cgattgaagg
    24181 tgttagacat caggcaagag aagaggggaa acttagggtt ttagtagaag ggccgataga
    24241 cgtgcctttc aagaatgttc caaaaacgat agaaatctgc aaacaatctg acgctgatga
    24301 agtttggtta ttaacttcaa gtccgataag ttcttatcct ggagtagaca aggtattctc
    24361 ccaagttcct atttttgaaa cagctcaaat ttacagatct tgtgatgtta ttatcaaact
    24421 cagttatgtg gaaggaatgt ttggtcctcc tctcgagatg ttccattgtg gtggtacctc
    24481 gataacatat aatgttacag gccatgatga atatattgtt tcagatcaga atgctttggt
    24541 tgctgcaaaa gatgatg
//
