LOCUS       NZ_JAFJXZ010000012     27353 bp    DNA     linear   CON 03-JUN-2024
DEFINITION  Paenibacillus polymyxa strain Hob6 Scaffold_12, whole genome shotgun
            sequence.
ACCESSION   NZ_JAFJXZ010000012
VERSION     NZ_JAFJXZ010000012.1
KEYWORDS    WGS; RefSeq.
SOURCE      Paenibacillus polymyxa
  ORGANISM  Paenibacillus polymyxa
            Bacteria; Bacillota; Bacilli; Bacillales; Paenibacillaceae;
            Paenibacillus.
REFERENCE   1  (bases 1 to 1543484)
  AUTHORS   Mahmoud,M. and Jabaji,S.
  TITLE     Draft genome sequence of Paenibacillus polymyxa strain Hob6,
            isolated from hemp (Cannabis sative) seeds' oil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 1543484)
  AUTHORS   Mahmoud,M. and Jabaji,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (24-FEB-2021) Plant Science Departement, McGill
            University, 21111 Lakeshore, te-Anne-de-Bellevue, Quebec H9X 3V9,
            Canada
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 22-JUL-2020
            Assembly Method                   :: SPAdes v. 3.12.0; Medusa v. 1.6
            Genome Representation             :: Full
            Expected Final Version            :: No
            Reference-guided Assembly :: GCA_000507205.2; GCA_014706575.1;
            GCA_000164985.2; GCA_000597985.1; GCA_002893885.1
            Genome Coverage                   :: 266.29x
            Sequencing Technology             :: Illumina HiSeq
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017589695.1-RS_2024_06_03
            Annotation Date                   :: 06/03/2024 02:57:45
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,275
            CDSs (total)                      :: 5,119
            Genes (coding)                    :: 5,024
            CDSs (with protein)               :: 5,024
            Genes (RNA)                       :: 156
            rRNAs                             :: 21, 9, 15 (5S, 16S, 23S)
            complete rRNAs                    :: 19, 2 (5S, 16S)
            partial rRNAs                     :: 2, 7, 15 (5S, 16S, 23S)
            tRNAs                             :: 107
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 95
            CDSs (without protein)            :: 95
            Pseudo Genes (ambiguous residues) :: 0 of 95
            Pseudo Genes (frameshifted)       :: 44 of 95
            Pseudo Genes (incomplete)         :: 63 of 95
            Pseudo Genes (internal stop)      :: 13 of 95
            Pseudo Genes (multiple problems)  :: 21 of 95
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:07:16
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 114810
            Orig. end                         :: 142163
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            JAFJXZ010000012.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
FEATURES             Location/Qualifiers
     region          1..27353
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     cand_cluster    1..27353
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="lanthipeptide-class-i"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..24366
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24366
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:14366](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14366
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(277..849)
                     /locus_tag="JYU28_RS03580"
                     /old_locus_tag="JYU28_03595"
     CDS             complement(277..849)
                     /EC_number="2.7.1.71"
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0004765 - shikimate kinase activity
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0008652 - amino acid biosynthetic process
                     [Evidence IEA]"
                     /GO_process="GO:0009073 - aromatic amino acid family
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819867.1"
                     /locus_tag="JYU28_RS03580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03595"
                     /product="shikimate kinase"
                     /protein_id="WP_029517614.1"
                     /transl_table=11
                     /translation="MQNNSEIPLKEQNIVLIGFMGVGKTTIGSHLARKLYRDFVDIDQE
                     IEQEYNMPTTEIFKTYGEKRFREIEKEHILKLCSNTRLKIISVGGGAFLQEEVKQACLA
                     SSIVFFLDLNWDSWKDRLKMLIDTRPNLQNKTLGEIEDLFRSRQDIYAVNHSKIDTDQL
                     DAEEVADYIIQTLNLGWELYEPTRGLN"
     misc_feature    complement(1258..1273)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 22.59"
                     /tool="antismash"
     gene            1404..2096
                     /locus_tag="JYU28_RS03585"
                     /old_locus_tag="JYU28_03600"
     CDS             1404..2096
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819868.1"
                     /locus_tag="JYU28_RS03585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03600"
                     /product="pectate lyase"
                     /protein_id="WP_029517613.1"
                     /transl_table=11
                     /translation="MKTNTANVLKKGISIALSGMLVALFVGNYSAHAAPEVVHKTILVK
                     AGEVYDGKGKTVVADPDTLGDGSQKEAQKPIFKLENNATLKNVIIAAPAADGVHVYGNG
                     TISNVTWEDVGEDALTLKEPGTVNITGGGAFHAYDKVFQINAEGTINIKNFRADDIGKL
                     VRQLGGSTFRVNMTLDNSDISNVKDSILRSDGPNSKAKITNTRYHNVKQLFKGFKSSNT
                     SESGNTQY"
     gene            2243..3280
                     /locus_tag="JYU28_RS03590"
                     /old_locus_tag="JYU28_03605"
     CDS             2243..3280
                     /EC_number="2.7.1.-"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013308931.1"
                     /locus_tag="JYU28_RS03590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03605"
                     /product="aminoglycoside phosphotransferase family protein"
                     /protein_id="WP_029517612.1"
                     /sec_met_domain="APH (E-value: 4.6e-13, bitscore: 46.0,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIVLLHFIQKSWVAMNPLYQYVNVDGTLNDTLVQNREILYTGTNG
                     RHVERFYVSSSESYIFKPLTNDDQKGRERWVYEHVLPALSPIYPRLLAWSDAGVDGGEE
                     WMVFEDLGPLHHLHADETLLRAVRLVAWWHALPTDRFAGIPLRGPKPLIQEMVSELYTR
                     KPDVLQLCSSLGLSKQQMQRMYVQLEHVSFSQQLVLSHGDLHPGNYALSGERLMVLDWE
                     HTHLNTPLWDVYHLIDMSHPLFPRRMTSELRIRILDTYVEQLELLGIRVDRTAFMLEYG
                     MFAVVFSLWMLLLITSDLQRIGTHLHRNGDKWSKEQLESQLDETLACLNQCAAMMDWGQ
                     AQRCR"
     misc_feature    2259..2272
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.72"
                     /tool="antismash"
     gene            3335..4333
                     /locus_tag="JYU28_RS03595"
                     /old_locus_tag="JYU28_03610"
     CDS             3335..4333
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014279969.1"
                     /locus_tag="JYU28_RS03595"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03610"
                     /product="glycosyltransferase"
                     /protein_id="WP_069012910.1"
                     /sec_met_domain="Glycos_transf_1 (E-value: 7.7e-12,
                     bitscore: 41.6, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVGLVMRKIQFAEAQGPRIFAERLKQIGLELGVNIVFVSPERH
                     VSSHDWLPGYEHEKGDLVNYDVVLDQLHEQQIEHVIYTVSGFTYLNMFFKNSVLFPHSF
                     PDPALTGYEMMKPFYQIVDKAIVQTAFLKQEMASKFGVTDVTVIPIGFNERLVEKHFDP
                     SQVVENRVMWIGRDEENRRPDLVLEYARHNPDKDVYMVFGGERYKESMKKYDIPDNVKL
                     QFALTQDEVFALMNTAKVYWSCSKFDTFAMPLTEALAMGKIVVKPEHPCYGHISSTHSF
                     SGNEKNWFELVNMAAASPRRVSTENQAYAMEQFSSQVMKQGYRDFFDHWLS"
     gene            complement(4458..4967)
                     /locus_tag="JYU28_RS03600"
                     /old_locus_tag="JYU28_03615"
     CDS             complement(4458..4967)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF018037.4"
                     /locus_tag="JYU28_RS03600"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03615"
                     /product="DUF1036 domain-containing protein"
                     /protein_id="WP_081317628.1"
                     /transl_table=11
                     /translation="MRKEVCMMSLFFTNNTSNTIYAAYAYPDSDCHPMNYSKMGWYRLE
                     PGDTREVWSGSVGGTTFYYYAENHSNRWRGTYRTRLPRSTDHDFHWCWNDSSGSSRRVG
                     MRRLAIDSSVDNYTVEFSRTNQSLLSTKKTRRALPSKSEDSGINRIPRRPVRFKKGTPV
                     PVKSKR"
     gene            complement(5079..6287)
                     /locus_tag="JYU28_RS03605"
                     /old_locus_tag="JYU28_03620"
     CDS             complement(5079..6287)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1184: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369570.1"
                     /locus_tag="JYU28_RS03605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03620"
                     /product="MFS transporter"
                     /protein_id="WP_029517609.1"
                     /transl_table=11
                     /translation="MSTQENMTANRFPPSLLWLTLGAFAIGMTEFVIMGLLPNVAHDLH
                     VTIPQAGQLITSYALGVAIGAPVLTVLTHKVPQKKLLCLLMIIFILGNLFSVIAPNYEF
                     LIAARMATALSHGTFLGAGSLIAARLVRPDKRAGAISMVLTGLTVANIIGVPFGTFIGQ
                     QLGWRASFGAIVVIGLISLFGIIRYIPVIHQDKPSSLKQEVRSLFNPKVLLMLLTGAVG
                     CGSLFTVFTYITPLLTDISGFAEHSITWILVLFGLGVTIGNIVGGKLADWKLLPSLIAN
                     YAVLAIILAILTFTLQNKVLAVITVFIWGIAAFGIMPGIQVRIMNLAYEAPLLASTSSH
                     SALNLGNAGGAFIGGVVINQMGLAAIPWVASLITVGGLLLMVVSYIVDRKTAHTEAIAE
                     IQS"
     gene            6504..7427
                     /gene="cysK"
                     /locus_tag="JYU28_RS03610"
                     /old_locus_tag="JYU28_03625"
     CDS             6504..7427
                     /EC_number="2.5.1.47"
                     /GO_function="GO:0004124 - cysteine synthase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006535 - cysteine biosynthetic process
                     from serine [Evidence IEA]"
                     /codon_start=1
                     /gene="cysK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819871.1"
                     /locus_tag="JYU28_RS03610"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03625"
                     /product="cysteine synthase A"
                     /protein_id="WP_069012911.1"
                     /sec_met_domain="PALP (E-value: 3.2e-71, bitscore: 236.5,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAPKVVYSITDLIGDTPCVRLQRLTGPQDAEVYVKLEYFNPSGSV
                     KDRAAGNLIAEAEKAGHLKPGGTIIEPTSGNTGIGLAMNAAARGYRAILVMPSNMTKER
                     VNILKAYGAEVVLTPAEERMPGAIRKALELGAEIDGSFIPHQFENEANPDIHRTTTALE
                     ILEQTEGKLDVFVASSGTGGTITGTGEVLRQHLPDLRIVVVEPKGSPVLSGGKPGPHKL
                     VGTSPGFVPTVLNTEVYDEIVQVSDEDAIAMTRAIAAQEGILVGPSSGATIWTAIQEAR
                     RLGAGKRVLCIAPDTGERYLSMGIFG"
     cand_cluster    6757..27353
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    6757..27353
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[16756:17353](+)"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      16757..17353
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     gene            complement(8372..8578)
                     /locus_tag="JYU28_RS03615"
                     /old_locus_tag="JYU28_03635"
     CDS             complement(8372..8578)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JYU28_RS03615"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JYU28_03635"
                     /product="hypothetical protein"
                     /protein_id="WP_141695547.1"
                     /transl_table=11
                     /translation="MAYACKNPICSYTGVSYKSAEEEMLSMKRSSYGYDVLALVDELRF
                     KQDMTVKELTDALQASQQVPKIC"
     misc_feature    8612..8621
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     gene            8842..8988
                     /locus_tag="JYU28_RS03620"
                     /old_locus_tag="JYU28_03640"
     CDS             8842..8988
                     /codon_start=1
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF038155.1"
                     /locus_tag="JYU28_RS03620"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03640"
                     /product="FDLD family class I lanthipeptide"
                     /protein_id="WP_226888859.1"
                     /transl_table=11
                     /translation="MFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCICTGSCS
                     NCK"
     CDS_motif       8842..8895
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MFDLDLRKSYEASELSPQ"
                     /locus_tag="JYU28_RS03620_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       8896..8988
                     /prepeptide="core"
                     /locus_tag="JYU28_RS03620_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="14.70"
                     /molecular_weight="2943.6"
                     /monoisotopic_mass="2941.6"
                     /core_sequence="ASIIKTTIKVSKAVCKTLTCICTGSCSNCK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MFDLDLRKSYEASELSPQ"
                     /leader_location="[8841:8895](+)"
                     /alternative_weights="2961.6"
                     /alternative_weights="2979.6"
                     /alternative_weights="2997.7"
                     /alternative_weights="3015.7"
     gene            9055..9996
                     /locus_tag="JYU28_RS03625"
                     /old_locus_tag="JYU28_03645"
     CDS             9055..9996
                     /GO_function="GO:0008236 - serine-type peptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075: alkaline serine protease, subtilase family"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686236.1"
                     /locus_tag="JYU28_RS03625"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03645"
                     /product="S8 family serine peptidase"
                     /protein_id="WP_209018268.1"
                     /sec_met_domain="Peptidase_S8 (E-value: 1.5e-22, bitscore:
                     76.6, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKPNIYNWHVARLTDHFSCGATVGQPLTILFIDTGVDKSHSEIQ
                     GNLVEAECKSFVPYEPCLSDYVGHGTQMVSSVTGKYILKGICPFARVVVYKITDKKGIS
                     KLEWLYRALEEGIAKGYPIINVSYRTEYEVDLFEFNRFQALVDCANAQGIWVVCSAGND
                     GRDITQEYRVPANLKGVYPIGSTNKNGDISGFSNTLNDQFFAPSGDEYEINYNNDWVMV
                     AKSSFDTEDYLYEVLGFDKAYTVGIGTSIASALFSGVVASLSGELIAQGMNAGRTEMEC
                     LLRQGARLIDVQRNYYEVSLAGSIRALRQMRG"
     gene            10001..13084
                     /locus_tag="JYU28_RS03630"
                     /old_locus_tag="JYU28_03650"
     CDS             10001..13084
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686237.1"
                     /locus_tag="JYU28_RS03630"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03650"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_069012912.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.6e-112,
                     bitscore: 372.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.3e-12,
                     bitscore: 43.9, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 6.8e-26, bitscore:
                     87.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLENFEISENYMYRKTLLGMEYYTQIFDHEQLDDDEYLDRLVRFV
                     QQQGLIDSIYVSSPSTYAALQSLEQGRTLKSKKKRNLILSLSKFISRAICRPTPFGLFA
                     GVGISRFGKTGGAGEHVVWATPDYSLIYRLIGLFHGDTDVRNELRLSVNNTSYIDHHRL
                     VISYQTLFAADQEERSTENISILKTPVIDFIMKILDKEQQTFLQLMQAIKDAFGVDDTI
                     STDFLQQLIEQGFLVSEMIPNPRDSAPLAHLIRTLKLLATPKAAYYSDILERVGQAIQD
                     ITVAAVKREGIEAVRKLVQLILPDYQGDLVKIDVRLNQVNEILLSDSDRQSLAQIASIL
                     SMLSTYRKEDTLSDYRQQFTEKYGVYEEVPLLQLFSKTLGLGKPEEYKSHYQNGDKYRH
                     KDEGRFRQLKALIAEWQTEALVNHSDIVLDEVKIQQLSELSLENVHVSFDLYYSCMENE
                     QGEVTFYLNNRAGSLEACQSFGRFAYMFDKDSRDEIFNFVRNPKDQKAGESAAEISFYP
                     FSPKITNIMTAGPTPDQSMDMATFPENRKLDVSQLLVGVEDSGYFYLKHRETGELVFPK
                     LSSMYNTELAPYLIRFLNDINLQYQTGWSHLEEYLYDSSFTPRVTYKNIIICPKKWTLY
                     ADKQLQSEEQFLSFLEDWIIKYNIPRYVYLVELDNKLLLDLDRHHHRKLLHKEYTRNPE
                     GKAAVIMETEKELFASANRYMEECVFFCKSPMFQYLPIDRLSAQATDKSLNKVLSSSVN
                     AVYYPGSDWISLQVYYNQEMLTDLLGSAFKTFMDNSAEYFIDQVFFVQYADKEPHIRLR
                     CKMSGSVEHQRFTALNYVFDFLNTVTSSGLVSSYSVVPYRPEILRYGGAAFIEQAERLF
                     AIDSYLVSGYYAGKRSINATDQMLFCCTGLFEVVNCAYPLAEDQLKAMAAIIDPKKFRQ
                     EYREHKEALFQRIQQTRSISLPASDTGDRLRQYAAYFTAIREADDRTNYYDDIMFSIMH
                     MFCNRVFGLDREKEELALHLCYYSLEDYLQVSKYHVAY"
     aSDomain        10448..10726
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JYU28_RS03630_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="4.60E-14"
                     /identifier="RREFam001.1"
                     /label="JYU28_RS03630"
                     /locus_tag="JYU28_RS03630"
                     /protein_end="242"
                     /protein_start="149"
                     /score="43.9"
                     /tool="antismash"
                     /translation="LSVNNTSYIDHHRLVISYQTLFAADQEERSTENISILKTPVIDFI
                     MKILDKEQQTFLQLMQAIKDAFGVDDTISTDFLQQLIEQGFLVSEMIP"
     gene            13095..14366
                     /locus_tag="JYU28_RS03635"
                     /old_locus_tag="JYU28_03655"
     CDS             13095..14366
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426262.1"
                     /locus_tag="JYU28_RS03635"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03655"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_069012940.1"
                     /sec_met_domain="LANC_like (E-value: 4.3e-50, bitscore:
                     166.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVKQVPGNLSEIVRQSAEIYKDIDTVTLLIKKHAMHDYPEMELI
                     SLASGYPGISLLLDKLDEVYPGEGWDALAFKYNQEIVRLIGNIPFHSLSLYTGLAGVIY
                     LFNECSRGSTRYTNVLSQTLDMFLSSYGEFYEETRGKLEDSLIEDSDLDLISGWTGIAA
                     ALMEVKERQDRYAGKLDAVLLKILQLITDAVGKLRHFGELPEQTIYYNLGMAHGITGAI
                     NLLAVAHLRRYPLTGLREVLEVAKTFLLGNIREWNGTLVIPNMFTPDESAETSRNPGYH
                     RDAWCYGTPGASVAMFRLGLALEDKALQQQALQLFNTVYSRPDSLRKVISPTICHGYAG
                     LLLIQHHFSRTAAIPFKNDFLHRMLSYRNTQEAVPFTDLEGRVDDPLSLDKVGLLDGCA
                     GVLLTLLTCDNENLSTWKQMLVFS"
     gene            14382..14939
                     /locus_tag="JYU28_RS03640"
                     /old_locus_tag="JYU28_03660"
     CDS             14382..14939
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819877.1"
                     /locus_tag="JYU28_RS03640"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03660"
                     /product="DUF5823 family protein"
                     /protein_id="WP_016819877.1"
                     /transl_table=11
                     /translation="MFILLKEIITVMVGLITDFLSFQLDAYFYIWFLVLFISSLAATLV
                     QRSEGTITYSTAECVGINVLVVVLYLVIGTILARYFASFEDQQIVAGDKIMLYKISFML
                     TSAVIIVDIILDRLKRGRKFSYSLEFLAGSAVCFLLFQLSNQTDWIGTKLSLSYIVMVA
                     IAAGVYTMAMKFLLEYENHKEK"
     gene            14954..16747
                     /locus_tag="JYU28_RS03645"
                     /old_locus_tag="JYU28_03665"
     CDS             14954..16747
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426264.1"
                     /locus_tag="JYU28_RS03645"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03665"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_081317629.1"
                     /transl_table=11
                     /translation="MELNMESTAYKKIGEEKQTAHSLLELIKIARWPKLALAWSIVFTL
                     ISAAFSLVLPIITGKLVDKISAMELTIQTAAVLISLFLAGGILNAVSSLLLRYVGSKFF
                     QELRLKIWEKIIHLPVNYFDNNENGKIISRMTNDLAIVSNFLAITLPSILADVLMVTGC
                     IIMLFVLDWRLMSVLVALIPITALLIYPIGRRMNRVAIEAQDAAADFSGELSKILYNIR
                     FIKATTSEKLEMKYTREILGRIFRLNIKEGILSAVIEPIVTIIIMLALVGMFWYGSAGI
                     AAGHITTGTLVSMIFYLFTMVSPLTQLSSFFSQYQKAKGASKEIYTIYNQQDEKQEKLG
                     SVPDMKSHDQNSDILHFANVSFSYNQGQPVLSNVELTFRGGTTTAIVGPSGSGKTTIFS
                     LIEKFYSEYNGEIYYNNVYLDKIRTEEWRRKISYVMQDSDLLVGSVRDNLVYGLNRDAD
                     DHEIYAALDTVGLKEVIYQLPDGLDTFVGERGVKLSGGQKQRIQIARCLLSDHEILLFD
                     EATANLDSESEQLVHDVIKLLSKNKMTIVIAHRLSTIYKADQIIFLDKGEVTGVGTHHE
                     LMSWHDKYRDYVQFQLPTQLS"
     gene            16757..17353
                     /locus_tag="JYU28_RS03650"
                     /old_locus_tag="JYU28_03670"
     CDS             16757..17353
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019686238.1"
                     /locus_tag="JYU28_RS03650"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03670"
                     /product="accessory gene regulator AgrB"
                     /protein_id="WP_256026160.1"
                     /sec_met_domain="AgrB (E-value: 1.1e-32, bitscore: 109.3,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MALYHQLSTWIIDKYFQDEELEAEKRAYVLYYLENILAGTEKILL
                     VLVSACLLGVLAETAAMLLSYTVVRRKSFGWHARKSHHCTWVSLLTFVFLPWLLKEVEW
                     NRFFLATLCLLSIILIARYAPADTECNPLVDPKLRRACRLQAIFLSIVFVFVAIALDFY
                     PWLIFGLFLEAVVITPVFYSIMRRSYANYEQYQEY"
     gene            17474..18820
                     /locus_tag="JYU28_RS03655"
                     /old_locus_tag="JYU28_03675"
     CDS             17474..18820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819882.1"
                     /locus_tag="JYU28_RS03655"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03675"
                     /product="GHKL domain-containing protein"
                     /protein_id="WP_245231541.1"
                     /transl_table=11
                     /translation="MEIEQKMITSGIYFLQYTSYLVIYHMVSGNGLSVFRMNYKLLLFL
                     VMYYFIGITALNNFGLIVYLFLFVLLALYGWLTDKYESLWVIGFYAILTIFITTLLGYF
                     ITVISYAVPYEYKNKWTAPFLTACSPPLIYLALRKLVSYLFPTPAVRLLKLYRIKLIVG
                     ASLILVLGIIGLGLIIYSECESNNPYPSRLKIVLMLIGLTSIFLMTINWLYRFLREREL
                     EKNKTEQYLQLEAYIMEIEKMYEDIRGFRHDYTNILLMLDEGIRTGDLSMIKRIYESSI
                     QPTASQLNGYSYSLDNLINLDVSELKSIITSKVLVAKKRGVDVKLEIDSGISEMYMDII
                     DLCRVISCFLDNAIDAALETCNPSINIVLIHEDDIQTVTIRNSYNHSALDGIKVNDLYK
                     RNFSTKADNRGLGLYNIAKVLRSNKYVTLDTKKEPDFFTQTLIIKRATS"
     gene            18817..19596
                     /locus_tag="JYU28_RS03660"
                     /old_locus_tag="JYU28_03680"
     CDS             18817..19596
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819883.1"
                     /locus_tag="JYU28_RS03660"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03680"
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_029517599.1"
                     /transl_table=11
                     /translation="MNIFILEDQFIQQRIMEKMVRKSCEELGICCSNLIVTSKPDLLLF
                     ESKACANNLYFLDIEISGCQMKGLEVAQEIRKYDMYGHIVFVTTHGHLSPLTFQYKVAA
                     LDFIIKDATQDEMEKKVRDVLAVAHQRKPVLDVDDWFILDNKFTKFQISFSSIYYFETT
                     GVPHKIRLVSENRTLEFYGDLKDIEAKDPRLFRCHRAFIVNLMKVESIDKSKKEIIFQT
                     NQNSGEARRIIPVSRQLLKHLLDKMGDRSLLNRPVYE"
     gene            19643..20401
                     /locus_tag="JYU28_RS03665"
                     /old_locus_tag="JYU28_03685"
     CDS             19643..20401
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426268.1"
                     /locus_tag="JYU28_RS03665"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03685"
                     /product="TraX family protein"
                     /protein_id="WP_029517598.1"
                     /transl_table=11
                     /translation="MEQRLSVQAEVKGIDATSLKLIAVLAMLIDHIGGLFFADFLGFQV
                     VGRITLPIMAFFVAEGYIHTRSFKKYTIRLALTGLASVVPYGLVFKDWYTSGNIMLTLL
                     MGLLAIWFYDNTTNPVLKYLAISALCVVSFLGDWSVIGVLLVLAFYVARKQQKIYNGWI
                     IAIIALMFIFGVIIIWAVPDSLSIMGINASTMNEYLYPFAIGGACIFALPLLSRYNGER
                     GKGPRTFFYLFYPLHLLALYLLKLAIDYYI"
     misc_feature    20465..20474
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.04"
                     /tool="antismash"
     misc_feature    complement(20668..20682)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 20.55"
                     /tool="antismash"
     misc_feature    20669..20683
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 21.71"
                     /tool="antismash"
     gene            20741..21718
                     /locus_tag="JYU28_RS03670"
                     /old_locus_tag="JYU28_03690"
     CDS             20741..21718
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017426269.1"
                     /locus_tag="JYU28_RS03670"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03690"
                     /product="aldo/keto reductase"
                     /protein_id="WP_039272461.1"
                     /transl_table=11
                     /translation="MKIMPLQKRGISDSRLALGCMPFGGEWSHAPFTQEHVVEAERAVE
                     AARSIGITMFDHADIYRMGKAEEIFGQILKGQPGLREQIVIQSKCGIFLPDGTLPGRFD
                     FSYAHIMESVDGILKRLGTEYLDILLLHRPDPLVEPEEVAKAFSELKASGKVRHFGVSN
                     MNVSQIRFLERSLTEPLIANQLEMSLAHLHFVDQTVHVNQQAGTNVHFGEGLLEYCQTE
                     DIQLQAWGPLAQGRFSGGSLEGAPEHVVKTAELVQKLASEKETTREAIVLGWLMKHPAR
                     IQPVIGSANPERIKACQDAERQSELMTREEWYELYVSARGQALP"
     gene            complement(21805..22605)
                     /locus_tag="JYU28_RS03675"
                     /old_locus_tag="JYU28_03695"
     CDS             complement(21805..22605)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016819886.1"
                     /locus_tag="JYU28_RS03675"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03695"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_029517596.1"
                     /transl_table=11
                     /translation="MSLFEKIFNYQIVSRLDESGAFATTSQERIWLKSMLADSAATEGF
                     TPATLDKLRQLLADDEPLEADGSLREKAGIPAVSVYHPLLRELRSILRSRSGICVTYKL
                     RNGRLHERMSGFPYKLEFSMVKKEWSLLWYNRRHRALMSTKLSNIVNITEDELLPEEAD
                     KFTQRILGILESRKEQGIIEIVPVYNGEMSRILYAFSCFEKEVEYVQEADTYRITLTFQ
                     ADECEYVLSKIRFLGKRVKVVQGSRLISRMKETTAKALARYEEE"
     gene            complement(22580..23905)
                     /locus_tag="JYU28_RS03680"
                     /old_locus_tag="JYU28_03700"
     CDS             complement(22580..23905)
                     /GO_function="GO:0003676 - nucleic acid binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007428946.1"
                     /locus_tag="JYU28_RS03680"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03700"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_029517595.1"
                     /transl_table=11
                     /translation="MARESFDKEIQFLRMLTLTSGAYNRQQFADRLGISVHTFDKTIRR
                     LKEIVQSVQQQLPAEHGHDFNEMLRFNYYESADPLLLFLFRAKSLKESESVRLSLLLTA
                     LQSQPMTTMELLDACCNGLPSDSSLPDEKTIRSDLKYLVEVGVVRKEPGGRPYRYAVRN
                     DLVTELTDEELLDLYDFVDIMANTQLPSVQGYLLRDHLKKAMRRQLGDREMAEPFLYKY
                     HYYSRILDEAHIHPLLHAIRQRRCVTFLYFSTSKRSMYGSQNTNPLFEKETDGREHTIL
                     PLQVIYDHQYGRWYILGHVGGKGIMKFRMEGMTQLVEGKPVPEQFHADLLAVLEEKMRY
                     SWLVDTGRPVKVRVRFFNPEGAKRNFIRERVLSQGQWGTIAEEESESFIYEITVNGITE
                     IKPWIRSFGSSCEVLEPQRLRKEFRQEWKELQAYYEPVRENI"
     gene            24105..25673
                     /locus_tag="JYU28_RS03685"
                     /old_locus_tag="JYU28_03705"
     CDS             24105..25673
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369575.1"
                     /locus_tag="JYU28_RS03685"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03705"
                     /product="limonene hydroxylase"
                     /protein_id="WP_069012914.1"
                     /transl_table=11
                     /translation="MFGRRKNEVLYPWVGKLSIYETIKQGLDPQGRLTDDHLPDDEEYW
                     AGHTMRWVAGGLDGAFGHHGAGGDGETDKIKDLAQLLSRQCRKPGMKTRRETYVRLMEE
                     NALSLIDTLLDAVREHPAIQPDRLYEEARWLAEHGAHRNVVKVGIALLGLLETDQHHEL
                     ILTLAKHDEFTLYAAVAIRNISEQANEQLYNLASQVHGWGRIHVVERLEPARQEIRDWL
                     LREGFRNNVMYEYLAYECAHKGELHTAIAVPHIDQELFDGAGDILSALLAAGGPAESID
                     DYEHATMVIGNYLRHAKTMCTTVKHFTIIMDTADFLDEEDDSWEARYEHEWTPELRKRY
                     ASICQQMMDDPQWVKPVEQELQYADSPHLHCAIRVARMLALDVWPVLFDQLSKYPVKPN
                     LYFELIKTEDEQRARKLVAFAEKHLPLEEISSGPADVPGFGPEYEAHQCLGILLQLLSS
                     YEGMGQELVAAGLWSPVISNRHAALHVLKEWPSEMWGEETTERLRRLSIDETEESIREQ
                     IREIL"
     gene            25693..26511
                     /locus_tag="JYU28_RS03690"
                     /old_locus_tag="JYU28_03710"
     CDS             25693..26511
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013369576.1"
                     /locus_tag="JYU28_RS03690"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JYU28_03710"
                     /product="nucleotidyltransferase domain-containing protein"
                     /protein_id="WP_069012915.1"
                     /transl_table=11
                     /translation="MTDVKHGQGFIQPEMRETILRELRALEQAEQVRIVYACESGSRAW
                     GFPSQDSDYDVRFIYVRPIEWYLSIFDKRDVIERPISDLLDINGWDLKKALQLFRKSNP
                     PLLEWLQSPISYLEQYAVADQIRAISPLTFSPKSCMYHYLNMARGNYRDYLQGEQVKIK
                     KYFYVLRPLLACSWIERHNSMPPMEFVELLEELIPAHTELYQVIEHLLDRKKAGEELDV
                     EPQLSVVNDFIEQQIAYFEQKAPLLQHMEGGRDQQLDDMFRAAVNEVWEV"
     misc_feature    26932..26946
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.2"
                     /tool="antismash"
     misc_feature    27025..27038
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: weak, score: 19.21"
                     /tool="antismash"
ORIGIN
        1 attattacga tgtcgatggc ggggaaaggt gtcgtgagcc gcctgaccgg agaactgttt
       61 ggttcggctt tgacctttgg tgccgctaag aaagcttccg caccggggca gattcctgtc
      121 actgaactga gagagatatt gacggtgctg catagccatt cttaaaagat ggatggcata
      181 ctcgccagtt agtaattagt aatatatcca caatgaatta aaaaggaagg cccccatgcg
      241 gtaagcatgc tggagccctc ctttttggtg taactcttaa ttcaatcccc gagtaggttc
      301 atataactcc caacctagat tcagcgtttg aataatatag tctgcgactt cttccgcatc
      361 caactgatct gtatcgatct tggagtgatt caccgcgtag atgtcctgtc tggaacggaa
      421 taaatcctca atttccccta aagtcttgtt ttgtagatta ggacgggtgt caatcagcat
      481 cttgagccga tctttccagg aatcccaatt taaatccaag aagaaaacaa tcgatgaagc
      541 caaacaagct tgcttcacct cttcctgtaa aaatgcacca ccgccaacgg aaatgatttt
      601 aaggcgtgtg ttgctgcaca gcttcaaaat atgctctttt tcaatctcac ggaaacgctt
      661 ctctccataa gtcttgaaaa tctctgttgt tggcatgttg tattcttgtt caatctcctg
      721 gtcaatatcc acgaaatcgc gatacagctt gcgcgctaga tgggaaccga tcgttgtttt
      781 gcctacaccc ataaagccga tgagcacaat attttgttct tttaatggaa tctcactatt
      841 gttttgcacg ataaccactc ttttctcacc agtaatgttg agatgtaacg cttcaaagca
      901 ctaaatacat tatacgttca tcaaccgtgt cattcaatag tatagagcac atcagcaatg
      961 aggtatacga taaaagagac tctgaatacc aattaagtga taaacagcag gcaaacgaaa
     1021 caaggtattt aagtattgtt taatgcgtaa attgaagaaa aacaaacttg cacaagtata
     1081 aaagagtcaa ttttgtgtac ttaattgaaa aaaaggacat attttggcgg aaaatatatt
     1141 gaaattactg gaaataggat tataatagaa ttatacaaat tgtaaatgta atcgctctat
     1201 ttacaatttg ttctttatat tttttataaa acgaaattac tttgaaccaa aaaccaagta
     1261 tacatatgca aatagttgaa tgatgcttta tagacgtgta tcggtcattg ggttcattgt
     1321 gcgaaggtgg tgatacggtc tacacgttct agtcaacgaa gagttggaac aatgaaaaat
     1381 atctacgaga gggatgaatt gacatgaaaa caaacacagc taacgtattg aaaaagggaa
     1441 tcagtatcgc tttatcagga atgttggtcg ccttatttgt cggcaattat tctgcacatg
     1501 cagctccaga agtcgtccat aagactatac ttgttaaagc aggagaagtt tacgatggta
     1561 aaggcaagac tgtagtggct gatcccgata ccttgggaga cggaagccag aaagaggctc
     1621 agaagcctat ctttaagctt gaaaataatg caacactgaa aaatgtgatc atcgctgccc
     1681 ctgctgcgga tggggtgcat gtatatggca acggcacaat ctccaacgta acgtgggagg
     1741 atgtcggtga agatgcgttg acgcttaaag aaccaggtac ggtaaacatt acgggcggtg
     1801 gagcgttcca cgcatatgat aaagtgttcc aaattaatgc cgaaggcacg attaacatta
     1861 aaaactttag agccgatgat atcggtaagc tggttcgcca acttgggggc tctacattta
     1921 gagtgaatat gactttggat aactcggata tttccaacgt gaaggattcg atcctgagat
     1981 cggacggtcc taacagcaaa gctaaaatta cgaatactcg ttatcataat gtaaaacaat
     2041 tgttcaaagg ttttaaatcc agtaatacga gcgagtccgg caatactcaa tattaattgg
     2101 tatagaatag agtaaggata ggagtgcgga tgtgataagg ggctgcccaa caggtcgtat
     2161 gatctgcttg gacaagcccc tttttgggtg caatgagtta cccctagatg atctgggctt
     2221 cgttcggaac gaggactgtg atatgatcgt gctattacat tttatacaaa aaagttgggt
     2281 agctatgaat cctctttatc aatatgtgaa tgttgacggc actttgaatg atacgctggt
     2341 gcagaatcgt gaaattttat atacaggtac gaatggtcga catgtggaac gtttttacgt
     2401 gtcttcctct gaaagttata tattcaaacc gctaaccaat gatgatcaga aggggcggga
     2461 gagatgggtg tatgagcatg tgcttcctgc gttatcaccg atctatcccc gattgctagc
     2521 ctggtctgat gcaggtgtgg atggcggaga agaatggatg gtttttgagg atcttggtcc
     2581 gttacatcat ctacacgcag acgaaacttt attgcgagct gttagacttg ttgcatggtg
     2641 gcatgctttg ccgacggatc gttttgctgg gataccgctg cggggaccaa agccactcat
     2701 tcaggagatg gtttccgagc tatacacgcg caagccggat gtgttacagc tttgcagctc
     2761 actaggatta tctaagcaac agatgcagcg tatgtatgta cagctggagc atgtatcttt
     2821 ttcacagcag cttgtactgt ctcatggtga tcttcatccg gggaactatg cgctgagcgg
     2881 ggaacggctt atggtgctgg attgggagca tactcatctg aacacaccgc tgtgggatgt
     2941 atatcacctg atcgacatgt cccatccgtt gtttccccga cgcatgacgt ccgaattgcg
     3001 tattcgtata ctggacacct acgtggagca gctggagctg ttggggataa gagtggatcg
     3061 aacggctttt atgctggaat atggcatgtt tgctgtggta ttttcgctct ggatgctgtt
     3121 gttaatcaca agtgatttgc aaaggattgg aacgcacctg catagaaacg gcgacaaatg
     3181 gtcaaaagag caattagagt cccagttgga cgaaacgtta gcctgtttga accagtgtgc
     3241 tgcgatgatg gattggggac aagcccagcg atgtagatag tagcttaaga catagactgt
     3301 atttagttag ccaaagaagg tagggaatat atccatgaaa aaagttggtt tggtcatgag
     3361 aaaaatacaa tttgctgaag cacagggtcc gcgtattttc gcagaacgtc tgaagcaaat
     3421 cgggttggaa ttgggggtga acatcgtatt tgtatcaccg gagcgccatg tgagcagtca
     3481 tgactggctt ccgggttatg aacacgaaaa aggcgacctg gtcaattatg acgtcgtact
     3541 ggaccaactc catgagcagc agattgagca cgttatttat acggtatctg gctttaccta
     3601 tttgaacatg ttttttaaaa acagcgtgct ttttccgcat agttttcctg atccggcact
     3661 gacaggctat gaaatgatga agccttttta tcagatcgtg gacaaggcta tcgtacagac
     3721 tgcctttctc aagcaggaga tggcttcgaa gtttggcgta accgatgtga cagtcatccc
     3781 gatcggattt aatgagcggc tggtggaaaa gcattttgat ccctcgcaag tggtagagaa
     3841 ccgggtgatg tggattggta gagatgagga gaaccgacgt ccggatttgg tactggagta
     3901 tgcgaggcat aatcctgaca aggatgtcta tatggtattt ggcggtgaac gctacaagga
     3961 aagtatgaag aaatatgata tcccggacaa tgttaaactt caatttgcgt tgacgcaaga
     4021 tgaggtgttt gcgctgatga acacggcgaa ggtgtactgg agctgctcca aatttgatac
     4081 gttcgccatg ccgctgaccg aagcgctcgc tatgggtaaa atcgtggtta agccagagca
     4141 tccttgctat ggacatatca gctctacgca ttctttttca gggaatgaga aaaactggtt
     4201 tgagctggtc aatatggctg ccgcctcacc ccgtcgggtt tctacagaaa atcaggcata
     4261 cgccatggaa cagttttcaa gtcaggtgat gaagcaggga taccgagact tttttgatca
     4321 ttggttaagc tgagcagcga ggcataatac tgtggttgca actcgcgttt gggtatccag
     4381 agtgaaataa aaataacccg caagggggtc actttttttc aaaaattcca tcttgcgggt
     4441 tacggttcat cattgactta tcgtttggac tttactggaa ccggggttcc ttttttaaag
     4501 cgaaccggtc ttctcggaat tctgttaatg ccggagtcct ccgatttgga aggtaatgct
     4561 ctacgagttt tctttgttga cagtaagctt tgattggttc tgctgaactc aacagtgtaa
     4621 ttgtctacag atgaatcaat ggcaagtcgg cgcatcccca ctcgtctgga tgatccactg
     4681 ctatcgttcc aacaccaatg aaaatcatgg tcagtacttc tcggaagccg tgtgcggtac
     4741 gtaccacgcc acctattgga gtgattctca gcataataat agaatgtggt tccccctaca
     4801 gacccgctcc atacttctct cgtatcacca ggctctagcc gataccagcc cattttagaa
     4861 taattcatgg gatgacagtc ggaatcagga taagcatagg cagcatagat ggtgttactc
     4921 gtgttgtttg taaaaaaaag gctcatcatg cacacttctt tcctcataaa ttggtattac
     4981 aatgtcatac tatgaggaat gtagaagaag agagtggaca atatctctca atctatgaaa
     5041 aatgaaccat tcgtttacgt ccaacttgct aaacgattct atgattgtat ctccgctatc
     5101 gcttcagtat gagctgtctt gcgatccaca atgtagctaa ctaccatgag tagcagaccg
     5161 ccgacagtaa ttagcgatgc aacccatgga atagcggcta gccccatttg attaataaca
     5221 actcccccga taaaagcgcc gcctgcgttg cccagattca atgcggaatg gctggaggta
     5281 gaggcaagca aaggagcctc ataggccaga ttcatgatgc gaacctgaat acccggcatg
     5341 atgccgaacg cagcaatgcc ccagataaag actgtaataa ccgccagtac cttgttttga
     5401 agcgtaaacg tcagaatggc caaaataata gccagtacag catagtttgc gatcagggat
     5461 ggcagcagtt tccaatccgc aagcttgccg ccaacgatgt tgccgatcgt tacccctagg
     5521 ccaaacagga cgagaatcca ggtaatgcta tgctcggcaa agccactaat atccgtaagc
     5581 aaaggcgtaa tgtacgtaaa gacagtgaac agactgccac aaccgactgc acctgtgagc
     5641 aacatcagca gcacttttgg attaaacagg cttcggactt cttgtttgag actggaaggc
     5701 ttgtcctgat gaatcaccgg aatataacga atgataccaa acagagaaat caagccgatg
     5761 accacaatgg ctccaaagga agcacgccag ccgagttgtt gtccgataaa ggtaccaaag
     5821 ggtacgccta taatgttcgc cacggtcaaa ccggtcagca ccatggaaat agcacccgcg
     5881 cgtttgtcag gacgaaccag tcgggcagcg atcagggaac cagctcccaa aaaggttccg
     5941 tgcgataatg cagtagccat acgggccgca atcagaaact cgtaattggg agcaatgacg
     6001 gaaaaaagat tgcctaaaat gaatatgatc attagcagac atagcagctt tttctgtggt
     6061 accttatggg ttaatacggt aagcacaggt gcaccaatag ccacaccaag tgcgtaactg
     6121 gtaattaact gcccggcttg cggaattgta acatgaagat catgggctac attgggcagt
     6181 agtcccataa tgacgaattc ggtcatgcca atggcgaagg caccaagggt caaccatagc
     6241 aaggagggag ggaagcggtt tgctgtcata ttttcttgag tactcataag tgtcttgtat
     6301 cctcctgaaa aaatagtaat gcgagtatat cactacaggc gatatctggc gacccatttt
     6361 gcaagaattt tacatactaa gttgataagt tttatgtaat ttacaaaagc gacaggtagg
     6421 aaggagccaa gtgtgttatt ttggtagtat gatatgaaga tcgtaaataa cgttgtaagg
     6481 aacgatccaa ggaggataca acgatggcac ctaaagtggt atatagtatt acagatttaa
     6541 taggagatac accttgtgta aggctccaac ggctcacagg gccgcaggat gcggaagtgt
     6601 atgtgaagct ggagtatttt aatccaagcg gcagtgttaa agaccgggcg gcgggcaacc
     6661 tgattgccga agcggaaaag gcaggacatc taaagccggg aggcaccatt attgaaccga
     6721 caagtggcaa cacgggaatt ggccttgcga tgaatgcggc agcccgaggt taccgtgcga
     6781 ttttggtgat gccctcgaat atgacgaagg aacgggtcaa cattttaaaa gcctacgggg
     6841 ctgaggtcgt actgacacca gcagaagaac ggatgccagg agcaattcgc aaggcacttg
     6901 aactgggggc tgaaattgat gggagcttta tcccgcatca atttgaaaat gaggcaaacc
     6961 ccgatattca ccgtacaacc acagcacttg aaattttgga acagacggaa gggaaactgg
     7021 atgtgttcgt cgcttcttcg ggaacgggcg gtaccattac gggaacgggt gaagtgctgc
     7081 gtcagcattt gccagatctg cggattgttg tagttgagcc gaagggctcg ccagtactat
     7141 ctgggggaaa acccggtcca cataagctag ttggaacgag cccgggcttt gttcccaccg
     7201 tactgaatac ggaagtgtat gacgaaatcg tgcaggtttc ggatgaggat gcgattgcaa
     7261 tgacacgggc gattgctgcc caggaaggga ttctggtggg cccctctagc ggagctacga
     7321 tatggacggc gattcaggaa gctcggcgtt tgggagcagg caaacgggta ctttgcattg
     7381 ccccggatac cggagagcga tatctgagca tggggatatt cggataagaa gatgtggatt
     7441 gggaccaaag tgattcgact catttatatg tagtatgatc cagcctcatt aagtgaagta
     7501 acaaaagtga attggcgata tggcaatcaa gaatacacaa gtataacaag atgactcctg
     7561 gagcgcctac ttcttcacta gcctattata gctcgacctt gaaatattat ctttgaaaga
     7621 ataaaggatg atgggagcga tatagtagat tctttttcaa tggaggaaca tagacattga
     7681 atacatcctt ttcataattc ataggttaat ttcactcctg acaattaata agccacaatc
     7741 cataaggttg tggcttatta attgtcgatt atagcttata ttcgtgagaa ttttaaaagt
     7801 ctcacggttc atgctccgtt cttcgatctt atttgtctct tcaggatcct cttgaaaaac
     7861 ccaaataatc agagaaggaa acaccgagcc tactatccat ttcagcaaga gctgcctcaa
     7921 acgggtcaac ttattagttg actgcttaaa tggttgtgga aaatagtata atgtacgctg
     7981 acattttttg gcttctctaa tattcgtgca gcgattatac ccaattcaag ctatttatca
     8041 aaaatatgca gcggctacgc aagtgggttg atcggttgtc cacgtatcga ttgtgaccac
     8101 tcgcacacca tcaggccaca actcttccga acgcacctat agaggttaaa tggactgaac
     8161 agcaaacgat cgctcgctgc ctcacttttc atatttttgg cggctagtac gtttccacta
     8221 aagacttcgc gcaagacgta caatttttca ttgccttttt ccggctggac tccacccata
     8281 gacaagagaa cgtcaccgtt ttgttccgtc gtttcggcca gtatcgtacg aatatggtca
     8341 tcgagatgca gcaaaaagag cttgatatcg ctcaacagat tttgggtact tgttgggatg
     8401 cctgtagtgc gtcagtcagt tcctttacag tcatgtcctg tttgaatcgc agttcgtcca
     8461 caagagccag cacatcgtag ccataggacg agcgcttcat gctaagcatc tcttcttcag
     8521 ccgatttata cgagacacct gtataagaac atatcggatt cttgcaagca tacgccatgc
     8581 tctaagcgtc aatcgtttcg ctctgtgtcg gtattttttt atgccatgcc gcatgggcag
     8641 caaaatgact gcaatttagg aggtttggaa tacctttcag gaataaagta taaaaaacgg
     8701 gagaattaga tatattcttt attcatcgac agcaagatat gacatacggt cactcacaat
     8761 aaacgtgatt taggggtacc actgaaatca tgtttattat aatctaattc agagaggaag
     8821 aggaaaatga aagtagatca aatgtttgac cttgatttaa gaaagagcta tgaggccagt
     8881 gagcttagcc cacaagcttc aatcatcaaa acaaccatta aggtatccaa agcagtatgt
     8941 aaaactctta cctgtatctg taccggttct tgttccaatt gtaaataatt cataagcgat
     9001 tcgtaagtca ggggtagtga aataggctac ccctacttac attatggaga ttgcatgata
     9061 aaacctaata tatacaattg gcatgtagcc cggctgaccg atcattttag ttgtggtgca
     9121 actgttggtc agccgcttac tatcctgttt attgatacag gcgtcgataa atcccactca
     9181 gagatccaag gtaatctagt tgaggcagaa tgcaagtcat ttgtacctta tgagccttgt
     9241 ctaagcgatt acgtcgggca tggtacacaa atggttagct ctgttaccgg caaatatata
     9301 ttgaagggga tatgcccttt cgctcgggtt gttgtctaca aaattacgga caaaaaagga
     9361 ataagcaagc ttgaatggtt gtatagagcg ctggaagagg gtattgctaa aggatatcca
     9421 attatcaacg tcagctatcg tacagaatat gaggtcgact tattcgagtt caataggttt
     9481 caggctttgg ttgactgcgc caatgcgcaa ggcatatggg tagtctgttc cgcaggaaac
     9541 gatggacgcg atattacgca ggagtacaga gtacctgcga atttaaaggg agtataccca
     9601 attggatcaa ctaataagaa cggggatatc tccgggttca gcaatacgct caacgatcaa
     9661 ttttttgcgc cgagtggtga tgagtatgaa atcaattaca acaatgattg ggtaatggtt
     9721 gccaaatcga gcttcgacac agaggattac ttatatgaag tgctgggatt tgacaaagca
     9781 tacacagtgg gtatcggtac gagtattgcc agcgccttat tcagcggagt tgttgcctct
     9841 cttagcggag agcttatcgc gcaggggatg aatgccggac gcacagaaat ggagtgtctg
     9901 ctccgtcaag gcgcgagact gattgatgtt cagcggaatt attatgaagt aagccttgcc
     9961 ggttcaattc gtgctttaag acagatgaga ggttgattgc atgttggaga actttgaaat
    10021 ctcggaaaat tacatgtacc ggaaaacgtt gcttggcatg gagtattata cgcagatatt
    10081 tgatcatgaa caactagatg atgatgaata ccttgacaga cttgtacggt tcgttcagca
    10141 gcaggggttg atagattcca tttatgtctc cagcccctcg acctacgctg cactgcaaag
    10201 cctggaacaa ggcagaacat tgaagtccaa aaaaaagcgg aatcttatcc taagtctaag
    10261 caagttcatt tcgcgggcaa tttgtagacc aacaccgttt ggactgttcg cgggagtagg
    10321 catttcccga tttggaaaaa cgggaggcgc cggggaacat gtcgtctggg caactccgga
    10381 ttatagccta atttaccgct taatagggct tttccatggg gatacggatg tccgcaatga
    10441 attgagactg agtgtaaata acacctctta cattgaccat cacaggctcg tcatctctta
    10501 tcagactctg tttgcagcag atcaggagga acgaagcact gaaaatatat ctattctcaa
    10561 aaccccggtc atagatttca tcatgaagat ccttgataaa gagcagcaga cttttctgca
    10621 gcttatgcaa gctataaaag acgccttcgg cgtggatgac acgatcagca cagatttttt
    10681 gcagcaattg atagaacaag gctttttggt aagtgagatg attcccaatc ctcgggatag
    10741 cgctcctctg gcgcatctga tacgtacact aaagctgctt gctactccca aggcagcata
    10801 ttactcagat attttggaga gagttggaca agccattcag gacattacag ttgctgcggt
    10861 caaacgcgaa ggcattgagg ctgtccgaaa actagtccag cttatccttc ccgattatca
    10921 gggcgacttg gtcaaaatag acgtaagact gaatcaggta aatgaaattc tattgtcgga
    10981 cagcgatagg caatcgttgg cccaaatagc ttcaatattg agcatgcttt ctacgtacag
    11041 gaaagaggat acactttccg actatcgtca gcaatttact gagaagtacg gagtatatga
    11101 agaagtgccc ttattgcagt tgttcagtaa aaccttgggg ctcggcaaac ctgaagagta
    11161 caagagccac taccagaacg gagataagta caggcacaag gatgaaggca ggttccgaca
    11221 gcttaaggcg ctaattgcgg agtggcagac cgaagcgctt gtcaatcatt cggatatcgt
    11281 gcttgacgag gtcaaaatcc aacagctgtc tgaattgagt ctggagaatg tccatgtctc
    11341 gttcgatttg tattattcct gcatggagaa tgagcaaggt gaagttacgt tttatttaaa
    11401 caacagagcc ggatcattgg aagcgtgtca gagcttcgga agatttgcct acatgtttga
    11461 caaggatagc cgtgatgaaa tcttcaattt tgtcaggaac ccgaaggatc agaaagcagg
    11521 ggagagcgcc gctgaaatct cattttaccc attcagtccc aaaataacta atattatgac
    11581 ggcaggcccg acaccagacc aatctatgga tatggccacg tttcccgaga atcggaaatt
    11641 agatgtttcc cagctgctgg taggggtgga ggattcggga tacttttatc tgaagcacag
    11701 ggaaacaggc gaactggtat ttcccaaact cagcagcatg tacaatacag agctggcgcc
    11761 ttatctgatc cggtttctga atgatattaa tctgcagtat cagaccggat ggtcccatct
    11821 ggaggagtat ctctatgatt cttcttttac accgagagta acctataaaa atatcatcat
    11881 ctgccccaaa aaatggacat tatatgcgga taaacagctc cagagcgaag aacagtttct
    11941 gtcctttctg gaggattgga tcataaagta taacattccg cgatatgtat atttggtgga
    12001 gctggacaat aagctgttgc tggatttgga tcgccatcat catcgaaagc ttttgcacaa
    12061 agaatatacc cggaatccgg aaggcaaggc ggccgttatt atggaaacgg agaaagaatt
    12121 gttcgcttcc gctaaccgat atatggagga gtgcgtattt ttttgcaaaa gcccgatgtt
    12181 tcagtacttg ccgatagaca gattgtctgc acaggctacc gataaaagct taaataaagt
    12241 gctgagttct tcggtgaatg ccgtttatta tccaggttcg gattggatat ccctgcaggt
    12301 atattacaat caggaaatgc taaccgattt gctgggcagt gcatttaaga cattcatgga
    12361 caatagcgcc gagtacttca ttgaccaggt tttttttgtc cagtatgcag ataaggagcc
    12421 gcatatcagg ctaaggtgca aaatgtcggg aagcgtagag catcagcgtt tcacggcctt
    12481 gaactatgtt tttgatttcc tgaatactgt aacctcgtcc ggattggtta gttcctattc
    12541 ggttgttcct taccggcctg aaattttgcg gtatggcggc gcagccttca ttgaacaagc
    12601 ggagaggtta tttgctatcg attcttatct agtttcaggc tattatgcag gcaagaggtc
    12661 aattaatgca accgatcaga tgttattttg ctgtaccgga ctttttgagg ttgtgaactg
    12721 cgcgtatccg ctggcagaag atcaattgaa ggctatggct gcgattattg atccaaagaa
    12781 attcagacag gagtatcggg aacacaaaga agcgctattc caaagaattc aacagacccg
    12841 ttccatatcc ttgccagcaa gcgatacagg cgacaggttg cggcaatacg ctgcatattt
    12901 cacggctatc cgggaagctg acgacagaac caattattac gatgatatta tgttcagcat
    12961 catgcacatg ttctgcaaca gagtgttcgg cctggaccgg gaaaaggaag agcttgccct
    13021 acacctgtgc tactacagtt tggaagatta tttacaggta agcaaatacc atgttgctta
    13081 ttgaggagga gcttatggcg gtcaaacaag tcccgggaaa tttatctgaa atagtcaggc
    13141 aaagcgcaga aatttacaaa gatatagata ctgtaaccct gctaatcaag aagcacgcca
    13201 tgcatgatta ccctgaaatg gagctgatat cattggcttc aggatatccc gggatcagcc
    13261 ttcttctgga taaactagat gaagtctacc cgggggaagg gtgggatgcg cttgctttca
    13321 agtacaatca ggagattgtg cgcttaatcg gcaatatacc gttccattca ttgtcactgt
    13381 ataccggatt ggcaggtgtt atttatctgt tcaacgagtg ttcaagaggt tcaacaagat
    13441 atacgaatgt gctctcacag acgctggata tgtttcttag cagctatggg gaattctatg
    13501 aggagacaag ggggaaattg gaagactcct tgattgagga tagcgacttg gatttgattt
    13561 caggatggac ggggattgca gctgcattaa tggaggttaa ggaacgccaa gacagatacg
    13621 ctgggaagct ggatgcggtg ctccttaaga tccttcaact gattacggat gctgtaggca
    13681 agctgagaca tttcggggaa cttcccgaac agaccattta ctataatctt ggcatggcgc
    13741 acggaattac aggagccatt aatttgctgg ctgttgcaca tctccgccgc tacccgttaa
    13801 caggattgag agaagtactg gaagttgcca agacttttct actcggaaat atcagagagt
    13861 ggaacggcac ccttgtcata cctaatatgt tcacaccgga tgaatccgca gagactagtc
    13921 ggaatccagg ttatcacaga gatgcatggt gttacggcac accgggagct tctgtggcta
    13981 tgttccggct gggattggcc ctggaggaca aagcgctgca gcagcaggct ctgcaattgt
    14041 tcaataccgt ctactccaga ccagattcgc taagaaaggt aatttcaccg acgatctgtc
    14101 acggctatgc aggcttgctc ctgattcagc accatttcag ccgtacggca gccataccgt
    14161 tcaagaatga ttttttgcat cgtatgttat cataccggaa tactcaagag gcagtaccct
    14221 ttacagacct tgagggaaga gttgatgatc cgttatctct cgataaagta gggctgctcg
    14281 atggatgtgc aggtgtattg ctgacactgc tgacctgtga taatgagaac ttgagtacat
    14341 ggaagcagat gctggtattt agctaaaagg aggagacggt aatgttcatt ttattaaaag
    14401 aaattattac agtcatggtg ggactgatta ccgattttct ctcttttcaa ctggatgcat
    14461 atttttatat ttggtttctg gtcctgttta tttcaagctt ggcagcgacc ctggttcaac
    14521 gaagcgaagg gactattacc tacagcacag ccgaatgtgt cggaataaat gtgctagttg
    14581 tcgtattata cctagtaatc ggtacaattt tggccagata ctttgcaagt tttgaggatc
    14641 agcagattgt tgctggagat aagattatgc tgtataaaat ttcttttatg cttacatccg
    14701 ctgtaattat agtggatatt atactagata ggttgaagag agggcggaaa ttctcctact
    14761 ctttggagtt tcttgccgga agcgccgtgt gcttcttact gttccaatta agcaaccaaa
    14821 cggactggat aggaaccaag ctgtcgctct cctatattgt catggtagcg atagccgcag
    14881 gtgtctatac aatggcaatg aagtttttgc tagaatacga aaatcacaaa gagaaatagg
    14941 tgattaagcc ataatggaat tgaatatgga gagcacggca tataaaaaga ttggtgaaga
    15001 aaaacaaacg gcccattcct tgctggagtt aatcaaaatt gcgagatggc ccaagcttgc
    15061 gcttgcttgg agcatcgtat ttacactgat ttccgccgct ttttcattag tattgccgat
    15121 cattacaggc aagcttgtcg ataagatctc agctatggag ctgacgatcc agaccgcagc
    15181 tgtgcttatt tcgctgtttc tggccggagg gattttaaac gccgtgtctt ctctgctcct
    15241 cagatatgtg gggagcaagt tttttcagga actgcgactg aaaatttggg aaaaaattat
    15301 ccatttgccg gttaattatt ttgataacaa cgagaacggc aaaatcatca gcagaatgac
    15361 gaacgacctt gctattgtaa gtaattttct ggctatcact ctgccttcta ttctggctga
    15421 tgtcctgatg gtcactggtt gcatcatcat gttatttgtg ttggattgga gattaatgag
    15481 tgtactcgtt gctctgattc ctataacggc gctactaatc tatcccattg gaagaaggat
    15541 gaatagagta gcgattgagg cacaggatgc agccgcagat ttttccggtg agttatccaa
    15601 aattctctat aacatcagat tcattaaagc gacgacgtcg gaaaagcttg aaatgaaata
    15661 tactcgggag atacttggac gtatctttcg cttgaacatc aaagagggaa tattgtcagc
    15721 tgtcattgag ccgattgtaa caattatcat catgctagct ttggtaggaa tgttttggta
    15781 tggaagcgcc ggcattgccg ctggacatat cactacaggt actttggtat ccatgatctt
    15841 ttatttgttt acaatggttt cgcctctgac ccagctcagc agttttttct cgcagtatca
    15901 gaaggccaag ggagcaagta aggaaattta tactatatat aaccagcagg atgagaagca
    15961 agaaaagtta ggcagtgtgc cggacatgaa aagtcatgat cagaattcgg atatcctgca
    16021 ttttgccaat gtttctttct cgtacaacca gggccaaccg gtattatcca acgtggagtt
    16081 aaccttcaga ggcggtacca ctacagcgat cgtagggcct tccggctcgg gaaaaacaac
    16141 aatattttct ttaatagaga aattttactc agaatataat ggagaaatct attacaataa
    16201 tgtatatttg gataagatta ggacggaaga atggcgtcgc aaaatatcct atgttatgca
    16261 ggatagtgac ttactggtag gatcagtgag agacaatctg gtatatggcc taaacagaga
    16321 cgcggatgac catgagattt atgcggctct tgatacagta ggcttgaagg aggtaattta
    16381 tcaattaccg gatggtttgg atacctttgt tggagaaagg ggagtcaaat tatcgggggg
    16441 acagaagcag cgaatccaga ttgccagatg cttgctttca gaccatgaga ttctgctgtt
    16501 tgatgaagct accgccaatc tggatagcga gtcagagcag cttgtacatg atgtaatcaa
    16561 gcttctctcc aagaataaaa tgaccattgt tatcgctcat cgtttgtcaa ccatctacaa
    16621 agcggaccag ataatctttt tggataaagg agaagtaacg ggggtaggca cgcatcacga
    16681 attaatgagt tggcatgata aatatcgtga ttatgttcaa ttccagcttc ctacacaatt
    16741 aagttaggga ggggcggtgg cgttgtatca tcaattgtca acgtggatca ttgataaata
    16801 ctttcaagac gaagaattgg aagcggagaa gcgtgcttat gtgctttatt atctagagaa
    16861 catactggct ggcacagaaa aaatacttct tgtattggtc agtgcctgtt tgctcggtgt
    16921 attagccgaa acggctgcga tgctgctttc ctatacagtg gtccggcgaa agtcctttgg
    16981 ctggcatgct cgcaagtcgc atcattgcac ctgggtcagt ctactgacct ttgtgtttct
    17041 tccctggctc ttaaaggaag tagaatggaa ccgctttttt ttggcgacgc tctgtctgct
    17101 ttctatcatt ctgattgcca gatacgctcc ggccgatacg gagtgcaatc cattggtaga
    17161 tccgaagtta agaagagcat gcagattaca agctatcttt ttaagtatag tgtttgtttt
    17221 cgtggccatc gcactagatt tttatccttg gttaatattc gggctgtttc ttgaagcagt
    17281 cgtcatcaca ccagtattct attccataat gagaaggagt tatgctaatt atgaacaata
    17341 tcaagaatat taaagaacac agaaacaacc atacccagag actcaaggct aagctactgg
    17401 agcatatgag taaaagaggt gaaggaggag ggatttgttt cgggttgttc tatgaaccag
    17461 tcaacccaaa agtttggaaa ttgaacaaaa aatgattaca tccggcattt attttttgca
    17521 atacaccagc tatcttgtaa tatatcatat ggtcagcggc aatggtctaa gcgttttccg
    17581 tatgaattat aagctgctgc tgtttttagt catgtattat tttatcggaa taacagctct
    17641 gaataacttc ggactgattg tttacctatt tctatttgtg ctactggcat tatacgggtg
    17701 gttgaccgac aaatatgaat ccttgtgggt cataggcttc tacgccatcc ttaccatctt
    17761 tattacgaca ctgctgggtt atttcataac ggtaatcagc tatgcggttc cttatgaata
    17821 taaaaacaaa tggacggcgc ccttcctaac cgcttgttca cctccgctga tctacttggc
    17881 gctccgaaag cttgtgtctt atttgtttcc tactccggcg gtcaggcttt tgaagctata
    17941 tcggattaag cttatcgtcg gagcttcttt aatcttagtc ttggggatca tcggactcgg
    18001 actcattatc tattcggagt gtgaaagcaa caatccgtat ccaagcagat taaagattgt
    18061 gttgatgctg atcggcttga cctccatctt cctgatgacg atcaattggc tgtatcgctt
    18121 cctgcgtgaa cgtgagctag agaagaacaa gacggaacaa tacctgcagc tggaggctta
    18181 tattatggag attgaaaaaa tgtacgaaga catccgcggc ttcagacatg actataccaa
    18241 tatcctgtta atgctggacg aggggatcag aactggggat ttgtcgatga tcaagcggat
    18301 atatgagagt tctatccaac ctactgcttc acagttgaac ggatattcct atagtctgga
    18361 taacctgatt aatctggacg tgagtgagct caagagtatt attacatcca aggtgctggt
    18421 ggcaaagaag cgtggagttg acgtaaaact ggaaattgat agcggtatca gtgaaatgta
    18481 tatggatatt atagaccttt gcagagtaat ctcttgtttc ctggacaatg caatcgatgc
    18541 ggcattagag acctgcaatc cgtccataaa tattgtactg atccatgaag acgatattca
    18601 gacggtgacg atacgaaact cttataatca ttctgcactt gacgggatta aggtgaatga
    18661 tctctacaaa cggaactttt caacgaaagc ggacaatcgg ggtcttggct tgtacaatat
    18721 agcaaaggtg ctgcgcagca acaagtatgt aactttggat accaaaaagg aaccggattt
    18781 tttcacgcaa acattaatta taaagagagc gacatcatga atatttttat cctggaagat
    18841 cagtttatcc agcagcgcat aatggaaaag atggtccgta aaagctgcga ggaacttggc
    18901 atctgctgca gcaatctcat tgtcaccagt aagccggatc tcctgctttt tgaatctaaa
    18961 gcttgtgcga ataacttgta tttccttgat attgaaatct cgggttgcca gatgaaggga
    19021 ctggaagttg cccaagaaat cagaaaatat gatatgtatg ggcatattgt ctttgtaact
    19081 acccacggtc atctgtctcc gcttaccttc caatacaagg tagcagctct tgatttcatt
    19141 atcaaggatg ctactcagga tgaaatggaa aaaaaggtaa gagacgttct tgctgttgcc
    19201 catcaaagaa agcctgtgtt ggatgtcgat gattggttta tactcgacaa taaatttacg
    19261 aaatttcaaa tttccttctc cagcatttat tactttgaaa caaccggtgt tccccacaaa
    19321 atccgtctgg tttccgaaaa cagaactctt gagttttacg gcgatctgaa agatattgag
    19381 gctaaggacc ccaggttgtt ccggtgtcat cgggcattta tcgtaaacct gatgaaggtg
    19441 gaatctatag ataagagcaa gaaggagatc atttttcaaa ccaatcagaa ttccggagaa
    19501 gcaaggcgca ttattcccgt ttcccgccaa ttgttgaagc acctcttaga taagatggga
    19561 gaccggagcc tcctgaacag acctgtttac gaatagaata gatatggagg gcatagtcct
    19621 tcgggaagaa aaggggagga atatggaaca aagattatcc gttcaagcag aggtgaaggg
    19681 cattgatgcc accagtttaa aattaattgc agtattagca atgctaattg atcatattgg
    19741 agggctattt tttgccgatt ttttgggctt tcaggtggta ggcagaatta cattgcctat
    19801 catggctttt tttgtagccg aaggatatat ccataccaga agcttcaaaa aatatacaat
    19861 acgccttgct ctaaccgggc tagccagtgt ggtgccttac ggattggtat ttaaagattg
    19921 gtatacttcg ggaaacatca tgctaacgtt gttgatgggc ctactggcaa tatggttcta
    19981 tgacaacacg accaatcctg tacttaaata cttggcgatt tcggctcttt gcgtagtctc
    20041 ttttttggga gactggagtg taattggagt gttactggtt ctagctttct atgtcgctcg
    20101 caaacaacag aagatttaca acggatggat tattgcaata attgcgctta tgttcatttt
    20161 cggagtcatc attatatggg ctgttcccga ttcgctcagc atcatgggca tcaacgccag
    20221 cacaatgaac gaatatcttt atccgtttgc gatcggcggg gcctgtattt ttgcactccc
    20281 tctgctatcc cgatataatg gagagagggg aaaaggccca cgaacctttt tctatttgtt
    20341 ttatccgctg catttgctcg cgctttatct gctgaagttg gctattgatt attacatata
    20401 agaagggctg tctaataagt aactaaaata aaaaaattgg acgggaaacg acatgttttc
    20461 cgtctatttt tttatatagt gcgatcggta tgaatgataa cttggcggtg aaagtccgcc
    20521 aatatacgca aaaatacctt gcttggcctc gtcccggatt tcataacgat taaggtgaat
    20581 cagttctttc ttcagtatgc tgtggaagga ctgaactcaa tacaagcatt gtcgaacacg
    20641 accgtaagta agtggtaaaa taggtgtgtg atagcggtcc cacggactct tcatatgtgg
    20701 atgaagcagg gaatattttg aaggttgaag gaggagcagc atgaagatta tgcctttaca
    20761 gaaacgtgga atctccgata gtcggctggc gcttggttgt atgccttttg gtggagaatg
    20821 gagccatgca ccgtttacgc aggagcatgt cgttgaagcg gagagagctg tagaagctgc
    20881 acgatccatt gggattacga tgttcgatca tgcggatatt tatcgtatgg ggaaagcgga
    20941 agagattttc ggtcagattt taaagggaca gccgggcttg cgtgagcaaa tcgtaattca
    21001 gtccaaatgt ggtatttttc tgccagatgg tacgctcccg ggccgttttg atttctcata
    21061 tgctcatatt atggagtccg tggatgggat cctgaagcgt ctgggtacgg aatatttgga
    21121 catcttgctg ctgcatcgcc ccgatccgct ggtagagccg gaagaagtag cgaaagcgtt
    21181 cagtgagctc aaggcatccg gcaaagtaag gcattttggc gtctctaata tgaatgtaag
    21241 ccaaattcgt tttctggagc ggagcctgac ggagccgctg atcgctaatc aactggagat
    21301 gagcctggca catctgcatt ttgtagatca gaccgtacat gtgaaccagc aggcggggac
    21361 gaatgtacat tttggtgaag ggttgctaga atattgccaa accgaggata ttcagctcca
    21421 agcctgggga ccgctggcgc agggacgttt tagcggaggt tctttggaag gggcgcctga
    21481 gcatgtcgtt aagacggcag agctggtgca gaagctggct tctgaaaagg aaacgacacg
    21541 tgaagcgatc gtccttggct ggcttatgaa gcatccagca cggattcagc ctgtcattgg
    21601 cagcgccaat cctgaacgaa tcaaagcatg tcaggatgcg gaacgccaga gcgagctgat
    21661 gacccgtgag gaatggtatg aattgtacgt cagtgcgcgc ggacaagcct tgccataact
    21721 cgtttaaaag ccctttccct cgtctcatta acagacggag ggaggggcta tttacatgga
    21781 tgtatctcat atttgcctca gtagctattc ctcttcgtag cgtgcaaggg ccttggctgt
    21841 tgtctccttc attcgtgaga tcagccggga gccttggacg accttgacac gtttgcccag
    21901 gaaacggatt ttggataaca catattcaca ttcgtctgcc tggaaagtga gtgtaatacg
    21961 ataggtatct gcttcctgaa catattcgac ctctttttca aagcaggaaa aagcatataa
    22021 aatacgagac atttcaccgt tatatacagg aacaatttcg atgatgccct gttccttgcg
    22081 cgactccagt ataccgagta tacgttgggt gaatttatcg gcctcttcgg gtagaagctc
    22141 atcttccgtg atgttcacga tattagatag cttggtagac atgagcgcgc ggtgtctgcg
    22201 attataccac agcaggctcc attctttttt gaccatggaa aactccagct tatatggaaa
    22261 accggacatt cgctcatgca agcgtccgtt gcgcagtttg taggtcacac agatgccaga
    22321 acgggatcgc agaatggaac gcaattcacg caagagtgga tggtataccg agacagcagg
    22381 gatacctgcc ttttcccgca aacttccatc ggcctccagc ggctcgtcgt ctgcaagtaa
    22441 ttgccgaagc ttatcaagtg tagccggggt aaaaccctct gtcgctgccg agtctgcaag
    22501 catagatttg agccaaattc tttcctgtga tgtggtagca aaagcgcccg attcatccag
    22561 ccgtgagacg atctggtagt taaatatttt ctcgaacagg ctcataatag gcttgcagct
    22621 ccttccattc ctgtctgaat tccttccgta gccgctgagg ctccaatacc tcacagcttg
    22681 atccgaagct gcgaatccac ggtttaatct cagtgattcc attcactgtg atttcataga
    22741 taaaggattc actttcctcc tccgcgatcg taccccattg tccctgtgac agcacacgtt
    22801 cccgaataaa gttgcgcttc gcgccctcag gattgaaaaa acgtacccgc accttcacag
    22861 gacgacccgt atcaacaagc cagctgtacc gcattttttc ttccaacacc gctagcagat
    22921 cggcatgaaa ctgctctggt acaggcttgc cctccaccaa ttgagtcatg ccctccatac
    22981 gaaacttcat gattccttta ccgcctacat gacccagaat ataccaacgt ccatattgat
    23041 gatcatagat gacttgtagg ggcagaatgg tgtgttcacg gccgtcggtc tctttttcaa
    23101 acagcgggtt tgtgttttgt gacccgtaca tgcttcgttt ggatgtcgaa aaatataaaa
    23161 aagttacaca gcggcgttgc cgaatggcgt gtagaagcgg atgaatatgg gcttcgtcca
    23221 gaatgcgtga ataatagtgg tatttatata aaaaaggttc ggccatctcc cgatctccga
    23281 gctgacggcg catggctttt ttaagatgat ctcgcagcag atatccctgt acagagggga
    23341 gctgggtgtt ggccataatg tctacaaaat catataagtc cagcagctcc tcgtccgtca
    23401 gttctgtcac cagatcgttg cggacagcat agcggtaagg tctgccgccg ggttccttgc
    23461 gaacgacgcc gacttcaacc agatatttca gatcggaacg aatcgttttc tcatccggta
    23521 gtgaactgtc ggaaggcagc ccgttgcagc aagcatccaa tagttccatg gtggtcatag
    23581 gctgtgactg tagcgctgtc agcagaaggg ataagcggac gctttccgat tccttgagcg
    23641 atttggcccg aaacagaaat aacaataatg gatcagccga ttcgtaataa ttaaagcgca
    23701 gcatctcatt aaaatcatgt ccgtgttccg caggcaactg ctgttgtacc gattggacaa
    23761 tttccttgag acgccggatt gttttatcaa aggtatgtac cgaaatgccc agtctatctg
    23821 cgaattgctg ccgattatag gcgccgcttg ttaatgtgag catacgcagg aattgaattt
    23881 ctttatcaaa actttctctc gccatgatgc attccccgtt tctgttgccg ttctccgaaa
    23941 gcaagtatcc ctttattcta acagggaagg gatgcaggaa aaagggaaat tattcatctt
    24001 tgtaatactt tcaccatgtt cacgacttcc aaaataaagc atcataggag tataagatag
    24061 cacgatgaaa taagaagcaa tacataacag aagggtgatg caacatgttt ggacgacgca
    24121 aaaatgaagt gttatatcca tgggtaggta agctttcgat ttatgaaacg attaagcagg
    24181 gactggaccc tcagggcagg cttacggatg atcatttacc agatgatgaa gaatattggg
    24241 caggtcacac gatgcgttgg gtggcaggag gattggatgg agcatttggg catcatggcg
    24301 ctggcggaga tggagagact gacaaaatta aggatctggc gcagttgttg tccagacaat
    24361 gccgcaagcc agggatgaag acgagacgtg agacgtatgt acgcttgatg gaggaaaatg
    24421 cgctcagcct gattgatacg ctgctagatg cggtgcgcga gcatccagca attcagccgg
    24481 atcgattgta tgaggaagca cgttggctgg ctgaacacgg agcacatcgc aatgtggtga
    24541 aggtcggtat tgcgctgctt ggattactgg agacggatca gcaccacgaa cttattttaa
    24601 cactagccaa gcatgatgaa ttcacgctat atgcagctgt agctatccgt aatatttcgg
    24661 agcaggccaa cgaacaattg tataatttag cctcacaggt acatggctgg ggacgtattc
    24721 acgtagtaga acggctggag cctgcgcggc aggaaatacg tgactggtta ttaagggaag
    24781 gattccgcaa caatgtcatg tatgagtatc ttgcttatga gtgtgctcat aaaggcgaac
    24841 tgcatacagc catcgctgta ccgcacattg atcaggagtt gtttgacggg gcgggtgata
    24901 ttctatcggc tttgctggca gcaggcggac ctgcggaaag tatagacgat tatgagcatg
    24961 ccactatggt cataggcaac taccttcgcc atgctaagac catgtgtacg actgtgaagc
    25021 attttacgat catcatggat actgcggatt ttctcgatga agaagacgat tcatgggagg
    25081 cacgttatga gcatgaatgg acgccggaat tacgtaaacg ttacgcgtca atatgccagc
    25141 agatgatgga cgatccgcag tgggtgaagc cagtagagca ggaactgcag tatgcagatt
    25201 caccgcatct ccactgcgcc attcgcgtag ctcgaatgct agcactagat gtatggcccg
    25261 tgctatttga tcaattaagt aaatatccag tcaagcctaa tctatacttt gaactcatca
    25321 agacagagga tgaacagcgg gctcgtaagc tggtggcttt tgcagaaaag cacttgcctc
    25381 tggaagaaat ttcttctggt cctgctgatg tgccgggctt tggaccggag tatgaagcgc
    25441 atcaatgtct gggtattttg cttcagctat tgtcttctta cgaaggaatg ggacaagagc
    25501 tagttgctgc cggactttgg agtccggtga tctccaatcg tcatgcagca cttcatgtac
    25561 tcaaggaatg gccttctgag atgtggggag aggaaacgac agagcgtctt cgccgcttat
    25621 cgatagatga aacggaggag tcgattagag aacagattcg ggaaatactt taatgataag
    25681 ggagggaaca acatgacgga tgtgaagcat gggcagggtt tcattcaacc ggaaatgcgt
    25741 gagacgattt tgcgtgagct gcgcgcgttg gagcaagcgg agcaggtgcg cattgtatac
    25801 gcctgtgaat caggtagtcg ggcgtggggg tttccttcac aggacagtga ctatgatgta
    25861 cgatttatct atgtaagacc catagaatgg tatttatcta tttttgataa gcgggatgtg
    25921 attgaacggc caatcagcga tttgctggat ataaacggct gggatttaaa aaaggcgctc
    25981 caattgtttc gcaaatccaa tccgcctttg ctggaatggc tgcaatctcc gatttcctat
    26041 ctggagcaat atgcagtggc tgatcagatt cgtgcgatct cgccgttaac cttctctccg
    26101 aagtcctgca tgtaccatta tctgaatatg gcgcggggaa attatcggga ttatttgcag
    26161 ggagaacagg tgaagattaa aaagtatttt tacgtgctgc gcccgttgct ggcctgtagc
    26221 tggattgaac gtcacaacag catgcctcca atggaattcg tagaattgct agaggaactc
    26281 attccggcac ataccgaact ttatcaggtg atcgaacatt tgcttgatcg taaaaaagcg
    26341 ggcgaggagc tggatgtgga gccacagctt tcggtggtga atgattttat cgagcagcaa
    26401 attgcttact ttgaacagaa ggcgccgttg cttcagcata tggagggcgg acgggatcag
    26461 cagttggatg atatgttccg cgctgcggtg aatgaagtat gggaagtata agctgggaag
    26521 gagaagtaga gtatgcacat cacgctaaaa gcaaccggaa acaatgctgg gatgatttcg
    26581 catttgcttg ccaaaaatcc ctacaatacg tatgatcgca cggaaaaggg tgcgcgtgta
    26641 cgcatggtgt acaccgtgtt taccgaggaa gaggcagaaa tcgtcattca ggcttcgcca
    26701 gattcgatag atttggtcaa aaacagtcca gatagctatg atattacaca atatattaat
    26761 gaccgggagt ttgtaaccag tagcttattt tgcacctata ttcgtggctc gcttggtacg
    26821 gcactgaacg gcaaacccaa agaagagtat gcaggatggg tgacgcatcc tttcgcgctg
    26881 gagttatcgt ttgggcccgt tgcttcagat ttgccggatt ctgtggtgga gggactattt
    26941 gctccgctgg gctatcaagt agtcatagaa cgagggaaag cggattattc ttttcaactg
    27001 aaaaatcgaa gcaccgtcag gtatgtcacg ctaagtgggc atcagacggt gcaacatgcg
    27061 ttgcgtcagt tattgctgtt gattccggtg ctagataatt ataagcacta ttacattagt
    27121 gaagaagagt ttgacaagct gagacgctat ggtgagggct ggttgccaga gcatccacta
    27181 cgcgagctta tcattcgacg cacgcttcgt tttaccaatc tgattgagca atttgagcaa
    27241 tcagattatg atgaaatagg tattaaaaaa tatattgaaa aggatactgt ccaagctcaa
    27301 aaggataagc acgaacagat tcaacagcca gaacagccac atgaggaagg gaa
//
