LOCUS       NZ_CP071839            21047 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 8248578
            Orig. end                         :: 8269625
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21047
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="atropopeptide"
                     /region_number="35"
                     /rules="atropopeptide_p450"
                     /tool="antismash"
     cand_cluster    1..21047
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="atropopeptide_p450"
                     /kind="single"
                     /product="atropopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21047
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11047](+)"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11047
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="atropopeptide_p450"
                     /neighbourhood="10000"
                     /product="atropopeptide"
                     /protocluster_number="1"
     gene            complement(616..1356)
                     /locus_tag="S1361_RS36380"
                     /old_locus_tag="S1361_36210"
     CDS             complement(616..1356)
                     /EC_number="2.1.-.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024880.4"
                     /locus_tag="S1361_RS36380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36210"
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_208036081.1"
                     /transl_table=11
                     /translation="MTADDDPLGWDTSAAAGAYRDRDMRLAERLIFPAVLERLSGSSGP
                     GRLALDIGCGTGAVAARLAATGGWTVQGVDPSADMLDIARADRAHPRVSYRLFDGRSLD
                     WLADGTVDAAVCCLVYCTDPDDHRLAGLTAEIRRVLRPGAPYVLADLNPAATGVVFSTL
                     RHGEPGAVYRDGDAVATLLRLRDGSAMTGVTYHRSLDRYRALLTEAGFPSPTVELPTLP
                     ADGAAEETAAETRIAPYMILTTHA"
     gene            1672..2232
                     /locus_tag="S1361_RS36385"
                     /old_locus_tag="S1361_36215"
     CDS             1672..2232
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004978969.1"
                     /locus_tag="S1361_RS36385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36215"
                     /product="DoxX family membrane protein"
                     /protein_id="WP_208036082.1"
                     /transl_table=11
                     /translation="MSIKRILNRSAPADPPAARATATEPFATAADCGLLLLRLSFGLFM
                     AGHGAQKVFGLFGGDGLTATARGFEALGYRPGKLFAVIGGLSELLGGLGLALGLLTPLA
                     AAALIGVMINAMATVTGAHGAWDADGGVEYNVCIAVAALAVAAIGPGRLSVDRFFPWGR
                     GGWGEAAVALGLGGLGAAITLAL"
     gene            complement(2561..2857)
                     /locus_tag="S1361_RS36390"
                     /old_locus_tag="S1361_36220"
     CDS             complement(2561..2857)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018560147.1"
                     /locus_tag="S1361_RS36390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36220"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_243769425.1"
                     /transl_table=11
                     /translation="MARPDRGEPDLAAVLHALGDPVRLELVRRMAENGESACSPEGVDV
                     PRSTLSNHWRILREAGITRTRRAGKARLMSLRRTDLDTRFPGLLAAVLAEGRR"
     gene            2928..3317
                     /locus_tag="S1361_RS36395"
                     /old_locus_tag="S1361_36225"
     CDS             2928..3317
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008749209.1"
                     /locus_tag="S1361_RS36395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36225"
                     /product="hypothetical protein"
                     /protein_id="WP_243769426.1"
                     /transl_table=11
                     /translation="MIQEMVMPVLATLARVYVDDLDAALPTFVELTGEQPRLRFTYRDL
                     HLASVGGYLLLAGTEEALAPYRGTHATTIVESVDEVLRIAERHGGEILDGPNEVPTGRN
                     LTVRHPGGATIEYVQFHATAGSAFA"
     misc_feature    complement(3472..3485)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: strong, score: 19.46"
                     /tool="antismash"
     gene            3481..5112
                     /locus_tag="S1361_RS36400"
                     /old_locus_tag="S1361_36230"
     CDS             3481..5112
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018569861.1"
                     /locus_tag="S1361_RS36400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36230"
                     /product="phosphodiester glycosidase family protein"
                     /protein_id="WP_208036083.1"
                     /transl_table=11
                     /translation="MRRTRIRGAARRSARVRARLAATVVLALTAPAFLPGPAEAGPART
                     TATEQWTTQTVAPGVTVRTGVLRHPGTRHSWTVTVQAPTSSRWSTNDPDAPVTWAEVST
                     RSWADDTARKLTHSGFEPRVESVQWPSYADTPHGLMGYRVRVGRFATQEEARTAASAVT
                     AAGFRTTASWTGYDIQEPADLENVHVAVIDPKTFDGSIEATHDGNVAQRETTSAVARKL
                     HSLVAVNGGFFVLSPGDGVPGTMSGIGAYRGELESMAAGSRSALLFEDGGRTVRIADLT
                     STATARAGKAAYAIQGINRVPGTLRDCGRPGSTPSELPWQDVTCRLADDMVRFTDAFRA
                     DLPTGPGAQVVLDASGRVVSVGARGGRVPEGGLVLQGIGRAADWLTAHAERYSRIKVSE
                     VVRTAEGRRVALDGDDSVVSAAPTLVKDGRIDIDAAAEGVVDPEYTSFGYAWANVRQPR
                     TMAGVDRRGRLILATVDGRLKNGSEGFTLYEAAAFMRSLGAVQAMNLDGGGSTAMAVDG
                     TLVNHPSDATGERAVGDTVQVLPAAD"
     gene            5063..5401
                     /locus_tag="S1361_RS39605"
                     /old_locus_tag="S1361_36235"
     CDS             5063..5401
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS39605"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_36235"
                     /product="SUKH-4 family immunity protein"
                     /protein_id="WP_243769427.1"
                     /transl_table=11
                     /translation="MNARSETPSRSCPRRTDVHRGCASAAARRRPAAPARPPGPTRTKA
                     HASLWLHQREQALDEEHGFSQDFYHQLADTMIEVPAAVDPTACRPAEAPDGYRYWPEVF
                     HDEAGGVL"
     gene            5580..6566
                     /locus_tag="S1361_RS36410"
                     /old_locus_tag="S1361_36240"
     CDS             5580..6566
                     /EC_number="1.1.1.-"
                     /GO_function="GO:0016616 - oxidoreductase activity, acting
                     on the CH-OH group of donors, NAD or NADP as acceptor
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039: aldo/keto reductase family oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669271.1"
                     /locus_tag="S1361_RS36410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36240"
                     /product="aldo/keto reductase"
                     /protein_id="WP_208036084.1"
                     /transl_table=11
                     /translation="MTDVPTRYLGELAVSAQGLGCMGMSHGYGATDDAQSTATLHRALD
                     LGVTFLDTSDFYGFGHNEELIGRAIAGRRDEVVLATKFGFANRLGEPTLIRGDAAYVRQ
                     ACEASLRRLGVDHIDLYYQHRVDPQVPIEETVGAMAELVQAGKVRHLGLSEAGAQTIRR
                     AHAVHPISALQSEWSLWTRDLEAEVAPVCRELGIGLVPFSPLGRGFLTGRYDSLDGLAE
                     TDVRRTQPRFADGNLERNLAIVAKLNELAAAKSVTAGQLALAWVQHRGEDVVPIPGTRR
                     QRYLEENLAALDVELTPEDLAAIEAAAPAEQIVGDRYDANSLTFVNR"
     misc_feature    6718..6731
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.63"
                     /tool="antismash"
     gene            6728..7099
                     /locus_tag="S1361_RS36415"
                     /old_locus_tag="S1361_36245"
     CDS             6728..7099
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014669327.1"
                     /locus_tag="S1361_RS36415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36245"
                     /product="hypothetical protein"
                     /protein_id="WP_208036085.1"
                     /transl_table=11
                     /translation="MRSIRRSMAAGLLGAAALGLWAPAHAVAGTGAGGVDAAQPSVTYC
                     GPDQATGLAVSADRTVSCATALQVAGAYNEAASGARDASATVRVGVTAWKCQERQGDPN
                     PYRECVDASDSGRRVILSS"
     gene            complement(7181..7837)
                     /locus_tag="S1361_RS36420"
     CDS             complement(7181..7837)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS36420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="nitrilase-related carbon-nitrogen hydrolase"
                     /protein_id="WP_243769428.1"
                     /transl_table=11
                     /translation="MDGVRLVSRGMASPVPPAATAHASRRTVTAAAVQAATPSFDTSAV
                     AGPRGGAAPGGGRCAGRRGRGPADFGITVGSRTPVGRDLFRRYHAAAVDVPGPEVDTLA
                     AVTRDLGCHAVVGAVGRHGGTLYCVALVFGPMAAWACTASSCRPPCPPTCTRSRATSPT
                     PSSSAGAPSSSPRSARCLDDLARARFDFDPTGHYARPDVFTLRVDESARTAVGGR"
     gene            complement(7945..8184)
                     /locus_tag="S1361_RS36425"
                     /old_locus_tag="S1361_36250"
     CDS             complement(7945..8184)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018548858.1"
                     /locus_tag="S1361_RS36425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36250"
                     /product="hypothetical protein"
                     /protein_id="WP_243769429.1"
                     /transl_table=11
                     /translation="MADIPDELVKMERSAEAERAQLAGLSGEEYDAQWRAWRRAAEAFQ
                     AAVTEHSTREGMSRYELEQAVKKAVRRAEEDPAR"
     misc_feature    8156..8171
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.19"
                     /tool="antismash"
     misc_feature    8364..8381
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.22"
                     /tool="antismash"
     gene            8407..8886
                     /locus_tag="S1361_RS36430"
                     /old_locus_tag="S1361_36255"
     CDS             8407..8886
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676838.1"
                     /locus_tag="S1361_RS36430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36255"
                     /product="carboxymuconolactone decarboxylase family
                     protein"
                     /protein_id="WP_208036086.1"
                     /transl_table=11
                     /translation="MTSPVPAGTARRIFIDKQSPKAYHALVQTSETVRAVAADAGLDRV
                     LVELVNLRVSQLNGCAYCLHLHTRAALRAGDTPQRLGVLAAWRETDLFTPAERAALALA
                     EATTAAADTAAQDTAWAAARDVLTEDQISAVTWVAVTINAFNRVSIMSRHPVRAE"
     gene            8927..9319
                     /locus_tag="S1361_RS36435"
                     /old_locus_tag="S1361_36260"
     CDS             8927..9319
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015655485.1"
                     /locus_tag="S1361_RS36435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36260"
                     /product="RidA family protein"
                     /protein_id="WP_208036087.1"
                     /transl_table=11
                     /translation="MTERRAILSGSTFEEQIGYARAVVDGDWVHVSGTTGFDYTTMTIS
                     DDVVEQAEQCLRNIGAALAEAGCGLADVVRVRYLLPDRADFEPCWPVLRRCFGEVRPAA
                     TMLECGLADPRMKIEIEAYARRPAAG"
     misc_feature    9748..9763
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.87"
                     /tool="antismash"
     misc_feature    9871..9887
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 15.62"
                     /tool="antismash"
     gene            10001..11047
                     /locus_tag="S1361_RS36440"
                     /old_locus_tag="S1361_36265"
     CDS             10001..11047
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     atropopeptide: atropopeptide_p450"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000172: Biaryl bond formation (75% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568017.1"
                     /locus_tag="S1361_RS36440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36265"
                     /product="cytochrome P450"
                     /protein_id="WP_208036088.1"
                     /sec_met_domain="atropopeptide_p450 (E-value: 4.7e-190,
                     bitscore: 629.8, seeds: 287, tool: rule-based-clusters)"
                     /sec_met_domain="p450 (E-value: 1e-12, bitscore: 46.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPSSTARARATVFAPRLAALLDDHLGQDVFRLEPDTVGVAGHEV
                     ADRILAARRATETERPTFKPLHGRSITRTEASAVTRTVGNDVRDALARPLPQDVDLAGP
                     WPLTGHLFLRDLILGQDPYRLRMLMSRNLELTPKLTWSVIAVGAALPGWPRPDARLTGL
                     ANRAARARGYQERRYVMGLYRRAAAPVCFTVSTLVTNALWLGSPFDDGTSNRNIILEAL
                     RLLPPSWNILRNASPEYPAVDGRIGERDDVLLLPLLSHRDPALWDDPDAFRPERWDRLD
                     PDTTPGYLPFGHTSERCWGRHMVMPLAELLLDLIRGSGLVVDPAQRVGRVPLLGLLGVE
                     EVRLTRPR"
     gene            complement(11151..12032)
                     /locus_tag="S1361_RS36445"
                     /old_locus_tag="S1361_36270"
     CDS             complement(11151..12032)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676839.1"
                     /locus_tag="S1361_RS36445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36270"
                     /product="DMT family transporter"
                     /protein_id="WP_208036089.1"
                     /transl_table=11
                     /translation="MIELAAVFAVAGAASNAVGTAFQRKAASLSSTGGIRLLAELVRRP
                     VWMIGMAGVICAALFQSLALVNGPLALVQPLFILELPFALLIAAPLMHRRLPPWGWWGV
                     GGCVAGLAVLLVAAAPHGATSQAPLARWIPALCLCVGAMAAAVLLASRGGPPARRAALL
                     AAASATGNALTAALLKSASGTFADEGFSAFLRSWQTYGFALAGVASVLLLENALQAGPL
                     AAAQPALTIGDAVVSLALGVTLFDERIRTGWWLVPEACGALLIVGGVLVLSRAVQRIIV
                     LPAPVEQQHSTT"
     gene            complement(12236..12787)
                     /locus_tag="S1361_RS36450"
     CDS             complement(12236..12787)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677152.1"
                     /locus_tag="S1361_RS36450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_208036936.1"
                     /transl_table=11
                     /translation="MNGPVRARTPRSRSTGGADMKLLGIYLNDHLAGATAGTQRIGHLA
                     RASRGTALGRALDGIAAEIAEDRMTLLEIMRDLDVPVRHYKVWGGWAAEKAGRLKLNGR
                     LVRRSPLSTVLELEALRLGVEGKAAGWTTLRRLAPTDERLDPALLDTLLDRAERQQDTV
                     EEWRVHEAETALRTTARSAG"
     gene            complement(<12851..13471)
                     /locus_tag="S1361_RS36455"
                     /pseudo=""
     CDS             complement(<12851..13471)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009063801.1"
                     /locus_tag="S1361_RS36455"
                     /note="incomplete; partial in the middle of a contig;
                     missing C-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNPARPAPGRLRFDGWIAGIGTASGTRVVLGHWPRSPFGPFSDVM
                     LEREDGHRLLLAPTRRTADFVAGTYAFDEVRIVPVRVRVTGDHWAVTAGALLDLRLTVG
                     RRNLPGILLRSVPGALAARTGWTALTDPAARVLLGARTRGSAGGGRREWYGARDLHRIS
                     AASAVHEGRDLGSLAPVEPAVRFGFGSTPRAPSLVRVTTTVSVP"
     gene            complement(13468..14205)
                     /locus_tag="S1361_RS36460"
                     /old_locus_tag="S1361_36280"
     CDS             complement(13468..14205)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386333.1"
                     /locus_tag="S1361_RS36460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36280"
                     /product="DUF2071 domain-containing protein"
                     /protein_id="WP_243769430.1"
                     /transl_table=11
                     /translation="MVSYGPPQRVYVPALRADWLTQTFVHWAYPPARIQPLLPRGLTVD
                     TFDGAAWVSLTPFVMAGVRPPGSPAALPPFAETNLRTYVRGPDGGQGLWFLSIEVACPV
                     MLAARAVGVPYHPGRLELARRDGVVDYSGARRGDGPRYRLTVRPGEPIRPSRQDVWLTS
                     RWRAYTRQLGALWETPVEHAPWPLREARLDALSETCTRVVGLPPPVTEPVVHFSDGVRN
                     VRLGVSHPIRHRGGTPAGATPDG"
     gene            complement(14264..14539)
                     /locus_tag="S1361_RS36465"
                     /old_locus_tag="S1361_36285"
     CDS             complement(14264..14539)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009193278.1"
                     /locus_tag="S1361_RS36465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36285"
                     /product="DUF4190 domain-containing protein"
                     /protein_id="WP_208036090.1"
                     /transl_table=11
                     /translation="MRLTAPPAYRTGRRDTEGMAVASFVLGLVGLLVLNLVLGPIAIVL
                     AVIALRRGTPRRFRALLGLGLGIADLVLLLVLASAHGTASWSVWGG"
     gene            complement(14542..14706)
                     /locus_tag="S1361_RS36470"
                     /old_locus_tag="S1361_36290"
     CDS             complement(14542..14706)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010356863.1"
                     /locus_tag="S1361_RS36470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36290"
                     /product="hypothetical protein"
                     /protein_id="WP_208036091.1"
                     /transl_table=11
                     /translation="MLFLVVALLLLGLVVGTAAYLPWPLTLVLGSLIAVWLVVFAGRER
                     RRRSRTRGV"
     misc_feature    complement(14831..14848)
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 14.89"
                     /tool="antismash"
     gene            complement(14918..15199)
                     /locus_tag="S1361_RS36475"
                     /old_locus_tag="S1361_36295"
     CDS             complement(14918..15199)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676842.1"
                     /locus_tag="S1361_RS36475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36295"
                     /product="hypothetical protein"
                     /protein_id="WP_208036092.1"
                     /transl_table=11
                     /translation="MNNPPSINSYVDRVTAGPGGAMTDEVGVITGDLTVATILLADGHS
                     ARVAIQHSGSDTWYTLAGSPAPVPAGRLAAYHRDLLGRIRRGGGTRAT"
     gene            complement(15291..15971)
                     /locus_tag="S1361_RS36480"
                     /old_locus_tag="S1361_36300"
     CDS             complement(15291..15971)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020117284.1"
                     /locus_tag="S1361_RS36480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36300"
                     /product="maleylpyruvate isomerase N-terminal
                     domain-containing protein"
                     /protein_id="WP_208036093.1"
                     /transl_table=11
                     /translation="MTTAHITEPARTLRAAYEAASAVVATLDDEESWLPTGCTGWAVRD
                     LVFHCLQDAQRGLVALHTPSDGPVDRDAVTYWQDWRPGTAGAANGRRWARVNGSMFLVF
                     GQLQELYRETLAAAAHAADAADPARHVATQGHVLTAGDLITTLAVEATVHHLDLTARLP
                     LAPGPSREGLTAVRATLDGLLGRPAPADWSDERYARVGTGRAAPTDAERAALGAAADRF
                     PLFG"
     misc_feature    complement(15870..15872)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(16219..17034)
                     /locus_tag="S1361_RS36485"
                     /old_locus_tag="S1361_36305"
     CDS             complement(16219..17034)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676843.1"
                     /locus_tag="S1361_RS36485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36305"
                     /product="ABC transporter permease"
                     /protein_id="WP_208036094.1"
                     /transl_table=11
                     /translation="MHLGRTARITLRIGAGLGFAVIYVPLLLVLVNSLNPDRSASWPPP
                     GLTLHWWSVAAHNSGARAALWVSVKAGLGATAIALVLGTLIAFAVARHRFFGRDTVSFV
                     VVLPIALPGIVTGIALNSAFGTVLAPLGVGLGLFTVIVGHATFCIVVVFNNVVARLRRT
                     ASSYEEAAMDLGATTFRAFADVTFPLVRSALLAGGLLAFALSFDEIVVTTFTAGPGIET
                     LPIWIFGNMTRPQQAPVVNVVAAVLVLLSVVPIYVAQRLSADTATSSRV"
     gene            complement(17068..17892)
                     /locus_tag="S1361_RS36490"
                     /old_locus_tag="S1361_36310"
     CDS             complement(17068..17892)
                     /EC_number="7.-.-.-"
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019069845.1"
                     /locus_tag="S1361_RS36490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36310"
                     /product="ABC transporter permease"
                     /protein_id="WP_243769582.1"
                     /transl_table=11
                     /translation="MPRLRLTLLLTAPLLWLTVLYLGSLAVLFVSAFWTTDSFTSQVVK
                     VWSTDNFHALFTTPVFRQVVLRSVGVALAVTVLCAVIAFPVAFYTARVARPRWRPLLVV
                     AILTPLWASYLVKVYAWRLILSEGGVADWMLAPLGLSGPGYGLPATVLTLTYLWLPYMI
                     LPVHTALEQLPANLLDASADLGARAGRTFRSVVLPMVLPSVAAGSVFTFSLSLGDYITV
                     QIVGGKTQLIGNLVYSNIELNLPMAAALGTVPVAVIVLYLLAIRRTGALNSL"
     gene            complement(17964..19163)
                     /locus_tag="S1361_RS36495"
                     /old_locus_tag="S1361_36315"
     CDS             complement(17964..19163)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676845.1"
                     /locus_tag="S1361_RS36495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36315"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_208036096.1"
                     /transl_table=11
                     /translation="MRLTRTLRASAVCAAALLLAAACDSSGSGSTSATGLNPPDLKAPT
                     KLGKTEGQVNLIAWAGYVEDGSNDPKVDWVSGFEKRTGCQVHSKVAASSDEMVKLMKTG
                     EYDAVSASGDASLRLIASGDAAPVNTGLVPHYKDVFGGLKNGAWNSVRGKMYGIPHGRG
                     ANLLMYNTAKVQPAPTSWSAVFDDAARYKGHVTAYDSPIYIADAALYLKATKPELKIKD
                     PYALDQKQFDAAVALLKRQNADVGEYWSDYLKEVSAFKSGDSVVGTTWQVIANLAAAEG
                     AKVKALVPKEGSTGWSDTWMVSAKAKHPNCAYKWLDWIVSPKVNAQVAEYFGEAPANSK
                     ACAETTDKNFCTVYHAADENYWKKIAFWNTPIEQCLDGRTDVTCVPYAKWVQAWTEIKG
                     "
     gene            complement(19192..20223)
                     /locus_tag="S1361_RS36500"
                     /old_locus_tag="S1361_36320"
     CDS             complement(19192..20223)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676846.1"
                     /locus_tag="S1361_RS36500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_36320"
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_208036097.1"
                     /transl_table=11
                     /translation="MEGIAIRLQGLRKSFGETTAVAGVDLEIRDGEFFSMLGPSGSGKT
                     TVLRLVAGFESPDHGRIELAGQEVTGLAPFERDVHTVFQDYALFPHMSVEQNVAYGLKV
                     RRIPKAERLVRARKALAEVRLEGYGQRRPAQLSGGQRQRVALARALVGRPRVLLLDEPL
                     GALDLKLREQMQVELKALQREVGITFVFVTHDQEEALTMSDRIAVFDGGRIAQVGTPAE
                     IYERPATPFVASFVGTSNLLEGEAAHRITGSPGTYNIRPEKIRVLKDAAEPDEPEHTTA
                     TGTVADVVYLGDATRFLVDLDGGGRLTALQQNLETSSADVAAYRGTRVRLQWHRRHAVR
                     LPS"
     misc_feature    20186..20202
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 21.97"
                     /tool="antismash"
     misc_feature    20197..20213
                     /note="TFBS match to NuR, Nickel-responsive regulator,
                     confidence: weak, score: 20.07"
                     /tool="antismash"
     misc_feature    20514..20527
                     /note="TFBS match to BldD, Development and antibiotic
                     global regulator, confidence: medium, score: 20.9"
                     /tool="antismash"
     misc_feature    complement(20938..20953)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 18.12"
                     /tool="antismash"
ORIGIN
        1 cggctggagt ccggacgagt tcgccgccgt cggtgtgccc gcccgtgaac gcggtgcacg
       61 caccgacgac cacctcgccg ccgtccgggc gctgtggccc cggcgccccg cggacttcga
      121 cgggccgtac accaccctgc gcgcggcgca cctcggagtg cccccggtca ccgccggcgg
      181 tccgcccgtg tgggtcggcg gccacagcga cgccgccctg cgccgcgcgc tgcggttcgg
      241 cgacggctgg tacggcaccg gcgccgacgc cgcggagatc accgacgtgc gacgccgcct
      301 gcgcggactc gccggcacag cggacgccga ccgcctcacg ctcgccacgg ccgcgttcct
      361 caccccgccc ggtctcccgg cggcggtcac ggcaccggga cggccgctcg gcggcagcgc
      421 gcccaccgcg gcgagcgtcg ccgacgacct cacccggctc gccgaggcag ggatcaccgc
      481 ctgcaccctg tggctgcccg tcgccgccga gcacgtcgag gaggccatgg agtggatcgc
      541 cgccgaggtg gtgccacggc tcccctgaca cggctgccgt cgaccggcga tccgtccagt
      601 gccccgggac gcgggtcagg cgtgcgtcgt gaggatcatg tacggggcga tccgggtctc
      661 cgccgcggtc tcctcggctg cgccgtcggc ggggagggtg ggcagctcca cggtggggga
      721 ggggaagccg gcctcggtga gcagggcccg gtaccggtcg agggagcggt ggtacgtgac
      781 gccggtcatc gcgctgccgt cgcgcaggcg cagcagcgtg gccacggcgt ccccgtcgcg
      841 gtacacggcg cccggctcgc cgtgccgcag ggtggagaag accacgccgg tcgccgccgg
      901 gttgaggtcg gccaggacgt acggggcacc gggacgcagg acccggcgga tctcggcggt
      961 gaggccggcc agccggtggt cgtcgggatc cgtgcagtac accaggcagc acacggcggc
     1021 atcgacagtg ccgtcggcga gccagtccag ggaccggccg tcgaacaggc ggtaggagac
     1081 acgggggtgc gcccggtcgg cacgggcgat gtccagcatg tccgccgaag gatcgacgcc
     1141 ctggaccgtc cacccgccgg ttgccgcgag ccgcgccgcc accgcgccgg tgccgcagcc
     1201 gatgtccagg gccagccggc cggggccgga gctgccggag agccgttcca ggacggcggg
     1261 gaagatcagt ctctcggcca gccgcatgtc gcggtcccgg taggcgccgg ccgcggcgga
     1321 ggtgtcccag ccgagggggt cgtcgtcggc ggtcaaggtc gctgcctcct gctgcgctga
     1381 agccgctccc ggacgaggga agcgggggtt cgcccggcag cctggcacag ggcacgggcc
     1441 gggccgggac cggcgggggc cgattccccc gacagcgggc gcgctgcgtg gacggttgac
     1501 ggcggggctg tgcacgtacg cccgccccgg atgcacgaca ccgcccgcga cggaaggatc
     1561 gtacgggggc gtgccccacg acgctgcgtg gagccgaccc tccaccggtc gctcggcagc
     1621 cgtccgagct gggggaaacg cccgctctgg ccctcccacc ggagcagtgt catgtcgatc
     1681 aagcgcattc tcaaccgttc cgcccccgcc gatccaccgg ccgcgcgtgc taccgcgacc
     1741 gagcccttcg cgaccgccgc cgactgcggc ctgctgctcc tgcggctgag cttcggcctg
     1801 ttcatggccg ggcacggggc tcagaaggtc ttcgggctct tcggaggcga tggcctgacg
     1861 gcgaccgcca ggggcttcga agcgctgggc taccgcccgg ggaagctctt cgccgtgatc
     1921 gggggcctgt ccgagctgct cggcggcctc ggcctggccc tcgggctgct cacaccgctc
     1981 gcggccgccg ccctgatcgg cgtcatgatc aacgcgatgg ccacggtcac cggtgcgcac
     2041 ggtgcgtggg acgcggacgg cggtgtggag tacaacgtgt gcatcgccgt cgccgccctg
     2101 gccgtcgccg ccatcggccc gggccgcctg tccgtcgacc gcttcttccc ctggggcagg
     2161 ggcggctggg gagaggccgc ggtcgccctc ggcctcggcg gcctcggggc ggcgatcacg
     2221 cttgccctct aggacgggcg tgccggggct ttgatggtga tcaccccagg ccgtcgggcc
     2281 ccgggccccg tagccgccgc cgtgcacgat gcccgccgca ccgtcacgcc gccggtcccg
     2341 cagtatcagc tcccctgcgc tcgccatttc ggcagtgcgg cccggatggc gagcgtgacc
     2401 ggctggtccg cgccgagcag ccgctcgcgg tcggccacca cgtatgccgc gcggaccacc
     2461 ccggctccgt ggcagccgga cgcaccccgg cgatgtgacg ccgggacgct cgggggcggc
     2521 cccgcgccgc atggccgacc gagccggcac ccgccggtgc tcagcgcctg ccctcggcca
     2581 gtacggcggc gaggagtccg gggaagcggg tgtcgaggtc ggtgcggcgc agggacatca
     2641 ggcgggcctt tcccgcccgg cgggtccggg tgattccggc ttcgcgcagg atcctccagt
     2701 gattggacag cgtcgaccgg ggcacgtcca cgccctccgg gctgcacgcg ctctcgccgt
     2761 tctcggccat ccggcggacc agttccagcc ggaccggatc gcccagtgcg tgcagcaccg
     2821 cggccaggtc cggttctcca cggtcgggtc gtgccaccgg tcctcctcgt cctcaccgcg
     2881 caacaccctt agtatgcagc tcacttcaac gtttcgggaa agtcgaaatg atccaggaga
     2941 tggtcatgcc ggtgctcgcc accctcgccc gcgtctacgt agacgacctc gacgccgccc
     3001 tgccgacctt cgtcgaactc accggggagc agccgcggct gcggttcacc taccgcgacc
     3061 tgcacctcgc gagcgtcggc ggttatctgc tcctcgcggg cacggaggag gccctggccc
     3121 cgtaccgcgg cacccacgcc accacgatcg tcgagtccgt cgacgaggtg ctgcgcatcg
     3181 ccgagcggca cggcggggag atcctcgacg ggccgaacga ggtacccacc ggccgcaacc
     3241 tgaccgtgcg tcaccccggt ggcgcgacca tcgagtacgt gcagttccac gcgaccgcag
     3301 ggtccgcgtt cgcctgagcc ggccggccga tgacgggctg gtgccggcga gttcacatgc
     3361 ctgttgcgat ccctttcgtt cgcgagacag tggatgtcac gtacggcacg tgaagtgggc
     3421 ctcgtgtcaa ggtgtgctcg gggcacggtc gccccccgac cattgatgag gtgcatgtgc
     3481 atgcgtcgta cccgcatccg gggtgctgca cggcgctccg ctcgtgtccg tgcccggctc
     3541 gcggcgacgg tcgtgctcgc cctcacggcc ccggccttcc tgcccggccc ggcggaggcg
     3601 ggtccggcgc gcacgacggc gaccgaacag tggacgacgc agaccgtcgc tcccggcgtc
     3661 acggtccgca ccggtgtcct ccggcacccc ggcacgcggc attcctggac ggtcacggtt
     3721 caggcgccga ccagcagccg gtggagcacc aacgatccgg acgcgcccgt gacctgggcc
     3781 gaggtctcca cccgcagctg ggctgacgac acggcccgca agctgaccca ctcaggcttc
     3841 gagccgcgcg tggagagcgt gcagtggccg tcctacgccg acactccgca cggactgatg
     3901 gggtaccggg tccgggtcgg ccgcttcgcc acccaggagg aggcgcggac ggccgcgtcg
     3961 gcggtcaccg cggccgggtt ccgcacgact gcgtcgtgga ccgggtacga catccaggag
     4021 ccggccgacc tggagaacgt ccacgtggcg gtgatcgacc ccaagacctt cgacggaagc
     4081 atcgaagcca cgcacgacgg caatgtggca cagcgcgaga ccacctcggc ggtggcgcgc
     4141 aagctgcact ccctggtcgc ggtcaacggc ggcttcttcg tgctgtcacc gggcgacggc
     4201 gtaccgggca ccatgtccgg gatcggcgcc taccgggggg aactcgagtc gatggcggcc
     4261 ggatcccggt ccgcgctgct cttcgaggac ggtggccgca ccgtccggat cgcggacctc
     4321 acgagcaccg ccaccgcccg ggcgggcaag gccgcctacg cgatccaggg catcaaccgg
     4381 gtccccggca cgctccggga ctgcggccgc cccggcagca cgcccagcga gctgccctgg
     4441 caggacgtga cctgccgact ggccgacgac atggtccggt tcaccgacgc cttccgggcc
     4501 gacctgccga ccggacccgg agcgcaggtc gtgctggacg cgtccggccg tgtcgtctcc
     4561 gtcggcgccc gcggcggccg cgtccccgag ggcgggcttg tgctgcaggg catcggcagg
     4621 gcggccgact ggctgacggc gcacgccgag cggtacagcc ggatcaaggt cagcgaggtc
     4681 gtccgcaccg ccgagggccg gcgcgtcgca ctcgacggcg acgactccgt cgtcagtgcg
     4741 gcgccgacgc tggtgaagga cggccggatc gacatcgacg ccgccgccga aggcgtggtc
     4801 gaccccgagt acacctcctt cggatacgcc tgggccaacg tccgtcagcc gcgcaccatg
     4861 gcgggcgtcg acagacgggg ccggctgatc ctcgcgacgg tggacggccg gctgaagaac
     4921 ggcagcgaag gattcaccct gtacgaggcc gccgcgttca tgaggtcgct cggtgccgtg
     4981 caggcgatga acctcgacgg cggcggctcc accgcgatgg ccgtcgacgg cacgctggtc
     5041 aaccacccgt ccgacgcgac cggtgaacgc gcggtcggag acaccgtcca ggtcctgccc
     5101 gcggcggact gacgtccacc ggggctgtgc atcggccgcg gcacgccggc gtccggccgc
     5161 gccggcccgg ccgccgggtc cgacacggac gaaggcccac gcctctctct ggctgcacca
     5221 gcgggagcag gccctcgacg aggagcacgg cttcagccag gacttctacc accagctcgc
     5281 cgacaccatg atcgaggtgc cggccgcggt cgacccgaca gcctgccgcc ctgccgaggc
     5341 cccggacggc taccggtact ggccggaggt cttccacgac gaggcgggag gcgtgctgtg
     5401 acgccgtgcg cagtacgcgc cacgcaccct tgacctcccg cccgggaacc ccgggcggcg
     5461 tcccacgcca ccacaggccg accgcagcct cggcgtccgc ccgttgcccc ctttgacatg
     5521 gagtgcactc cagcacatag cgtcctggga aacgatcatc gagcccagga ggcagcagca
     5581 tgaccgacgt ccccacccgg tatctgggtg aactggccgt ctccgcgcag ggactgggct
     5641 gcatgggcat gagccacggc tacggcgcca cggacgacgc gcagtcgaca gccaccctgc
     5701 accgcgccct cgacctcggc gtgaccttcc tcgacacctc cgacttctac ggcttcgggc
     5761 acaacgagga gttgatcggg cgggccatcg ccgggcggcg cgacgaggtg gtgctggcca
     5821 ccaagttcgg cttcgccaac cgcctgggcg agcccaccct gatccgcggc gacgccgcct
     5881 acgtacgcca ggcgtgtgag gcatccctgc gtcgcctcgg tgtcgaccac atcgacctct
     5941 actaccagca ccgcgtcgac ccgcaggtgc cgatcgagga gaccgtcggc gccatggccg
     6001 agctggtgca ggccggcaag gtccgtcacc tggggctgtc cgaggcgggc gcgcagacca
     6061 tccggcgcgc gcacgccgtg cacccgatct cggcgctgca gagcgagtgg tcgctgtgga
     6121 cccgggacct ggaggcggag gtcgccccgg tctgccgcga gctcggcatc ggcctggtcc
     6181 cgttctcgcc gctcggacgg ggcttcctga ccggacggta cgactcgctc gacggcctgg
     6241 cggagaccga cgtacggcgc acccagccgc ggttcgccga cggcaacctc gaacggaacc
     6301 tggcgatcgt cgcgaaactg aacgagctgg ccgcggcgaa gtccgtcacc gccggccagc
     6361 tcgccctcgc ctgggtgcag caccgcggcg aggacgtggt gccgatcccc ggcacccggc
     6421 ggcagcggta cctggaggag aacctcgcgg cactggacgt cgagctgaca ccggaggacc
     6481 tcgccgcgat cgaggccgcc gccccggccg agcagatcgt gggcgaccgc tacgacgcga
     6541 acagcctcac cttcgtcaac cgctgacacc gcccggcact ccgctcccgg acgggctacg
     6601 gcggccggca aacccggtaa gcggatcgag gaccggggaa ggctgggtac acggcgtacc
     6661 cggtcttccc cgtcccgggg aggaacacac aggccacccc gtcagcgccg tgaaggaggc
     6721 acaccctatg cgctcgatca ggaggagcat ggccgcgggc ctgctggggg ccgctgcgct
     6781 gggcctctgg gccccggccc acgcggtcgc cggcaccggt gccggcggcg tcgacgccgc
     6841 tcagccatcg gtgacgtact gcgggccgga ccaggccacc ggcctggcgg tgtcggccga
     6901 ccggaccgtg tcctgcgcca cggctctgca ggtggcgggc gcctacaacg aggccgcctc
     6961 cggtgcgcgg gacgcatccg cgacggtccg tgtcggcgtg accgcgtgga agtgccagga
     7021 gcgtcagggc gacccgaacc cctaccggga gtgcgtcgac gcgagcgaca gcggccgccg
     7081 ggtcatcctc tcgtcctgac cggcacccct ggcggcacgt gccgccaggg ccgcgccgga
     7141 cagcgtgccg tcaccgtcga cggcggcacg ccgttgccgg tcagcggccg ccgacggccg
     7201 tgcgggcgga ctcgtcgacg cggagcgtga agacgtccgg gcgggcgtag tggccggtcg
     7261 ggtcgaagtc gaagcgggcg cgggcgaggt cgtcgagaca cctcgccgag cggggagacg
     7321 atgacggagc ccccgccgat gaggacggtg tcgggctcgt cgccctggac cgggtgcacg
     7381 tcggagggca gggcggtcgg catgagcttg ccgtgcaagc ccaggcagcc atcggcccga
     7441 agacgagagc gacgcagtac agggtgccgc cgtgtcgccc gacggcgccg acgacggcgt
     7501 ggcagccgag gtcccgcgtg acagcggcca gggtgtcgac ctcggggccg gggacgtcga
     7561 cggcggcggc gtggtagcgg cggaacaggt cacggccgac gggggtccgg ctgccgaccg
     7621 tgatgccgaa gtccgcagga ccacgacctc ggcgccccgc gcaccggccg cctcccggag
     7681 cagctccacc gcgcgggccg gcgacggcag acgtgtcgaa cgacggggtg gccgcctgga
     7741 cggcggcggc ggtcacggta cggcgggacg cgtgggccgt agcggcgggg ggcaccgggg
     7801 aggccatgcc cctggagacc aggcggacac cgtccacgcc ggcagtccgg acccgacggc
     7861 gacccggccg ccgctgtccg tgccccggta caccgtcacc acggttcctg ctgctcgcct
     7921 catccaggtc gttctcggct ggggttaccg cgccggatcc tcctctgcgc gccggaccgc
     7981 cttcttcacc gcctgctcca gctcgtaccg cgacatgccc tcgcgcgtcg agtgctcggt
     8041 caccgcagcc tggaacgcct cggccgcccg tcgccaggcc cgccactgag cgtcgtactc
     8101 ctcaccgctc aggccggcca gctgcgcgcg ctccgcttca gcggagcgtt ccattttgac
     8161 caattcgtcg ggaatgtctg ccatacctgg atgctatgca cggcgccacc ggggtgcccg
     8221 tcagcaccgc cgcggggtcg gtgctgtgtg ccgggatgcg gcccggccgc ccaggagtcc
     8281 ggaagtctcc ggcccgcacc gggtgggcgt ggggtgctct ggaccggagc ggcgtcgaaa
     8341 cctcggtcac cgacgccccg agcatgatag tttcgcgttc aacaaatctg tccggaggag
     8401 tgcaggttga ccagtcccgt accggccggc accgcccggc ggatcttcat cgacaagcag
     8461 agcccgaagg cgtaccacgc actggtgcag acttcggaga cggtccgggc ggtcgccgcc
     8521 gacgcaggcc tggaccgggt cctggtggaa ctggtcaacc tccgtgtgtc acagctcaac
     8581 ggctgtgcct actgcctgca cctgcacacc cgggccgcgc tgcgggcggg cgacaccccg
     8641 cagcgcctcg gagtgctcgc cgcctggcgc gagaccgacc tgttcacgcc ggccgaacgc
     8701 gccgccctgg ccctcgccga ggcgaccacc gccgcggccg acaccgccgc ccaggacacc
     8761 gcatgggcgg cggcgcggga cgtcctgacc gaggaccaga tatcggcggt gacctgggtg
     8821 gcggtcacca tcaacgcctt caaccgggtt tcgatcatga gccggcaccc ggtgcgggcc
     8881 gagtagcgct tggacgtgcc gacgccggtc acctagcgtt cggcgcatga cggaacgacg
     8941 cgcgatcctc agcggctcca ccttcgagga acagatcggt tacgcccgcg ccgtggtcga
     9001 cggggactgg gtgcacgtct ccgggaccac cggcttcgac tacaccacca tgaccatctc
     9061 cgacgacgtg gtggagcagg ccgaacagtg cctgcgcaac atcggggccg cgctggccga
     9121 ggcggggtgc ggcctcgccg acgtggtgcg ggtgcgttac ctgctgccgg accgcgcgga
     9181 cttcgagccc tgctggccgg tgctgcgccg ctgcttcggc gaggtccggc ccgccgccac
     9241 catgctggag tgcggcctcg ccgacccccg gatgaagatc gagatagagg cgtacgcccg
     9301 ccgccccgcc gcgggctgag ccgccgaccc cgacgacccc ccgccccccg cgtcccctga
     9361 gcccccctgg gtgccgtgcc gtccgcgccg ggaaggccga tgcccgccgg gcgaaggccc
     9421 gtcggtgcaa ggtggccttg tccggtgggt gatcacggcg gtgcgtatcc ggtcaatgtg
     9481 gcttcgccgc tcccgtcggc cgaggtgcga cgggcgtccg ctctcggtga ccggccgtcc
     9541 ggcattcggg cggtcgccgc cgcccgtcac cagtgcggtg aggtcccggc ggcggttcgg
     9601 tttccctcgg cctctcggcg tgtcaaaccg gagcgccggt gaccggcgaa agtccgaaat
     9661 cgactacggc gcaggggctt tgagcgccct ggtgattaac cggtgaacgg tcgcgggaag
     9721 gttccggggt gtcgccgaca cgtgatcttc accggctggt ccggaccgac gcgtgtcatc
     9781 cgtccgcccc cgaggggagg tgcagtgatg aagcttctct tcgcccttcg caaccgcgtt
     9841 gccgccgcca agagcctcaa ggccaacgcc tggtacttct ggtactgatc cgcaccgctg
     9901 tggcgccgac atcgttgtcc ggccgaaccg cggcgcggtc cggccggaca gcggtgtccc
     9961 gtcgactctc cgcagccccc gcccccgtac cggagcagcc atgccgccgt catccaccgc
    10021 gcgtgcgcgc gccaccgtgt tcgccccacg gctcgccgcg ctcctcgacg accacctggg
    10081 ccaggacgtc ttccggctcg aacccgacac cgtcggcgtc gcggggcacg aggtcgccga
    10141 ccgcatcctg gccgcacgcc gggccaccga gaccgaacgc cccaccttca aaccgctgca
    10201 cgggcgttcc atcacccgca ccgaggcctc ggcggtcacc cgcaccgtcg gcaacgacgt
    10261 acgcgacgcc ctggccagac ccctgccgca ggacgtggac ctcgccggcc cctggccgct
    10321 gaccggacac ctcttcctgc gtgacctgat actcggtcag gatccttacc gactgcgcat
    10381 gctgatgagc cgcaacctcg aactcacccc gaagctcacc tggtcggtga tcgcggtcgg
    10441 ggccgccctg cccggctggc cccggccgga cgcccggctc accggcctcg cgaaccgtgc
    10501 ggcgcgggcg cgggggtacc aggaacggcg gtacgtgatg ggtctgtacc gcagggccgc
    10561 ggcccccgtg tgcttcaccg tctccacgct ggtgaccaac gccctctggc tcggctcccc
    10621 gttcgacgac ggcacgtcca accggaacat catcttggag gcgctgcggc tcctgccgcc
    10681 ctcgtggaac atcctgcgca acgcctcacc cgagtacccg gccgtcgacg gccgcatcgg
    10741 cgagcgggac gacgtcctgc tgctgccgct gctgtcccac cgggaccccg ccctctggga
    10801 cgaccccgac gccttccgcc cggaacgctg ggaccgcctc gaccccgaca ccacccccgg
    10861 ctacctgccc ttcgggcaca cctcggagcg ctgctggggc cggcacatgg tcatgccgct
    10921 ggccgagctg ctgctggacc tgatccgcgg ctccgggctg gtggtcgatc ccgcgcagcg
    10981 ggtcggccgg gtgccgctgc tggggctgct gggcgtggag gaggtacggc tcacacggcc
    11041 gcgctgacgg ggggagggcc ggcgggggcc gtcggcgggt gcaggccacg atcgacgtca
    11101 tcgagtcggt gcccggagag ccgccgctcg tcgccgctcc cacagctgcc tcacgtcgtc
    11161 gagtgctgct gctcgaccgg agccggcagc acgatgatgc gctgaacggc ccggctgagg
    11221 accagcacac ccccgacgat cagcagggca ccgcaggcct ccggtacgag ccaccagccg
    11281 gtgcggatcc gctcgtcgaa gagggtcacc cccagggcca ggctgaccac cgcgtcaccg
    11341 atggtcagcg cgggctgcgc cgccgccagc ggaccggcct gcaacgcgtt ctccagcagg
    11401 aggacggagg cgacaccggc gagcgcgaag ccgtacgtct gccaggaccg caggaacgcc
    11461 gagaagccct cgtcggcgaa cgtgccgctg gccgacttca ggagggcggc ggtcagcgcg
    11521 ttgcccgtcg ctgaggcggc ggccaggagc gcggcgcgcc gggccggcgg acctcctcgg
    11581 ctcgccagca gcacggccgc ggccatcgcg ccgacacaca ggcacagggc cgggatccac
    11641 cgggcgaggg gtgcttgact ggtcgcgccg tgcggggcgg ccgcgacgag cagcacggcg
    11701 aggcccgcca cacagccgcc cacgccccac cagccccagg ggggcagccg ccggtgcatc
    11761 agcggggccg cgatcagcag cgcgaacggc agctccagga tgaacagcgg ctggaccagc
    11821 gcgagcgggc cgttgaccag cgccaggctc tggaacagcg cggcacagat cacgccggcc
    11881 atgccgatca tccagacggg ccggcgcacc agctccgcga gcagccggat cccaccggtg
    11941 ctgctcaacg aggccgcctt gcgctggaac gcggtgccca cggcgttgct cgccgctccc
    12001 gcgacggcga acaccgcggc cagttcgatc acgagcatct cctgccggcc ggcagacctc
    12061 ccggaggagg aacgagtccc tccagcctac gaaaggcacc gctgatccgc tccggccggc
    12121 gggtggaaac gccgggtggc aggggagcgg gggagcgcat cgggtggttg gaggaccggg
    12181 tcggccggga ccggtgcccc ggtcggcccg gtcggggcgg tgtcccggtc cggggtcacc
    12241 cggcggaccg ggcggtcgtg cgcagggccg tttccgcctc gtgtacgcgc cactcctcca
    12301 cggtgtcctg ctggcgttcg gcccggtcga ggagcgtgtc gaggagggcg gggtccaggc
    12361 gctcgtcggt cggggcgagc cggcgcaggg tggtccaccc ggccgccttg ccctccaccc
    12421 ccagccgcag cgcctccagt tccagcaccg tgctgagcgg ggagcgccgc accaggcggc
    12481 cgttgagctt gagccggccc gccttctcgg ccgcccagcc gccccagacc ttgtagtggc
    12541 gcaccgggac gtccaggtcc cgcatgatct ccagcagcgt catccggtcc tcggcgatct
    12601 cggcggctat gccgtcgagg gcgcggccga gcgcggtacc ccgggaggcg cgcgccaggt
    12661 ggccgatccg ctgggtgccc gcggtggcgc cggcgaggtg gtcgttgagg tagataccga
    12721 gcagcttcat gtcggcgcca ccggtcgatc gcgaccgggg ggtacgggcc cgtaccggtc
    12781 cgttcatgac gatcctcctt cgttggtcct gcggcttcgg acggggccgt gcacggcttc
    12841 cggccgtgcg cggcacgctc accgtcgtcg tgacgcgtac gaggctcggt gcccggggcg
    12901 tcgagccgaa accgaaccgg acggcgggct ccaccggggc gagcgagccg aggtcccgcc
    12961 cttcgtggac ggcgctcgcc gcgctgatcc ggtgcagatc acgggcgccg taccactcgc
    13021 gccggccgcc gcccgcgctc ccgcgggtcc gcgccccgag cagcacacgg gccgccgggt
    13081 cggtcagcgc ggtccagccg gtgcgggcgg ccagcgcacc ggggacgctc ctcagcagga
    13141 tccccggcag gttcctgcgg cccacggtga ggcgcaggtc gagcagcgcg ccggcggtca
    13201 ccgcccagtg gtcgccggtg acgcggaccc gtaccggcac gatccgcacc tcgtcgaagg
    13261 cgtaggtacc ggcgacgaag tccgccgtgc gccgggtcgg ggccagcagc aggcggtggc
    13321 cgtcctcccg ctccagcatc acgtcgctga acgggccgaa cggcgagcgg ggccagtggc
    13381 cgagcaccac gcgggtcccg gacgccgtac cgataccggc gatccagccg tcgaagcgca
    13441 gccggccggg ggccggcctg gcgggattca tccgtccggg gtggcaccgg cgggcgtccc
    13501 gccgcggtgc cgtatcgggt gcgagacgcc caggcgcacg ttccggaccc cgtccgagaa
    13561 gtgcacgacg ggctccgtca cgggcggggg cagccccacg acccgggtgc acgtctccga
    13621 gagcgcgtcg aggcgcgcct cgcgcaaggg ccacggggcg tgttcgacgg gggtctccca
    13681 gagcgcgccg agctgccggg tgtaggcccg ccagcgcgag gtcagccaca cgtcctgccg
    13741 gctgggccgg ataggctcgc ccggtcggac cgtcaggcgg taccggggcc cgtcgccccg
    13801 ccgcgccccg ctgtagtcca ccacgccgtc gcgccgcgcc agctccaggc ggcccgggtg
    13861 gtacggcacg cccacggcgc gggcggccag catcaccggg caggccacct cgatggacag
    13921 gaaccacagc ccttgcccgc cgtccgggcc ccgcacgtag gtgcgcaggt tggtctccgc
    13981 gaagggaggc agggcggccg gcgagccggg tgggcgcaca ccggccatga cgaacggcgt
    14041 gaggctcacc cacgccgcac cgtcgaacgt gtccacggtc agcccgcgcg ggaggagggg
    14101 ctggatgcga gcgggcgggt aggcccagtg cacgaacgtc tgggtcagcc agtcggcccg
    14161 cagcgccggg acgtacacgc gctgcggggg tccatacgag accacgggca ccgactcccc
    14221 cggagcgcgg ccccgaaacc cggcgtgccg tgccccgggg tgctcagcca ccccacacgg
    14281 accaggacgc cgtcccgtgc gcggacgcca ggacgaggag caggaccagg tcggcgatgc
    14341 cgagtcccag cccgaggagg gcgcggaacc ggcgtggggt gccccgccgc agggcgatga
    14401 cggccagcac gatggcgatg gggccgagga cgagattgag gacgaggagt ccgacgagtc
    14461 cgaggacgaa ggaggccacg gccatgccct cggtgtcccg ccggcccgtc cggtacgcgg
    14521 ggggagcggt cagccgcatg gtcagacccc cctcgtccgg ctgcggcgcc gtcgttcccg
    14581 gcccgcgaag acgacgagcc agacggcgat gagtgagccg agcaccagcg tgagcggcca
    14641 ggggagatag gcggccgttc ccacgacgag gcccagcagg agcagggcga cgaccaggaa
    14701 gagcacggct acctccccgc cccgctgagc gttgccgcgc tgaccgggca cggtggtttt
    14761 cgcaccggtc cggtcggctg gtcgatcggc tgcccgtgcc gctgctgcca cggctgttcg
    14821 gtccgcttct tcaacgcgtt catgacatcg cgggttaccc gcgagcgccg tctcacgcag
    14881 cccttcccga cgggtcgtca gccgtgccgg ccccggctca ggtggcgcgc gttccgccgc
    14941 cccggcggat acggcccagc agatcccggt ggtaggcggc gagccggccg gccggcaccg
    15001 gggccgggct cccggccagg gtgtaccagg tgtcgctgcc ggaatgctgg atggcgaccc
    15061 gcgcgctgtg gccgtcggcc agcaggatgg tggcgacggt gaggtcgccg gtgatgacgc
    15121 cgacctcgtc ggtcatcgcc ccgcccgggc cggccgtgac ccggtcgacg taactgttga
    15181 tgctcggagg gttgttcatg gggcgcaggt ttccatcaac ccggccggga tgccccgcac
    15241 cgcgcaggtg tcgcccgcgg gagtccccgc gttgggcgtg cggccggccc tcagccgaac
    15301 agcgggaacc ggtccgccgc cgcgcccagg gcggcgcgtt cggcgtcggt cggcgcggcc
    15361 cgcccggtgc ccacgcgcgc gtaccgctcg tcgctccagt ccgccggggc gggtctgccg
    15421 agcagaccgt ccagcgtggc acgcaccgcc gtcaggccct cgcgcgaggg gccgggggcg
    15481 agcgggagcc gggcggtcag gtcgagatgg tggacggtcg cctccaccgc cagcgtggtg
    15541 atcaggtccc cggccgtcag cacgtgcccc tgggtggcca cgtgccgcgc cggatcggcc
    15601 gcgtccgccg cgtgcgcggc cgccgccagc gtctcccgat acagctcctg caactggccg
    15661 aagaccagga acatgctccc gttcacccgc gcccagcgcc gcccgttcgc cgcgcccgcg
    15721 gtgcccggcc gccagtcctg ccagtacgtc accgcgtccc ggtcgacggg cccgtccgac
    15781 ggcgtgtgca gggccacgag tccgcgctgg gcgtcctgca gacagtggaa gacgaggtcg
    15841 cggaccgccc agcccgtgca gccggtcggt aaccaggact cctcgtcgtc cagcgtcgcg
    15901 acgacggccg aggcggcctc gtaggcggcg cgcaacgtcc gcgccggttc cgtgatgtgc
    15961 gctgtggtca tgcgatctcc cgggagcgtg ctgcgaacgt ggacgcgcgg gccggaccgt
    16021 acggctcgcc ggggcggccc cgcctcggcc gtcgccgtcg gccgcggacg tccgtgtacc
    16081 cgcccgcgga tgcgccagtg ctccgcgtcc gggccgtcgg ccggcgtcgc gccggcgccc
    16141 cgtcgagggc cgccggccgt ccccggcgac ccagccggcg ggaccgtgtt cccggccgaa
    16201 cgcgcgagcc gcgtgccttc acacccggct cgatgtcgcg gtgtccgcgg acagccgctg
    16261 ggcgacgtag atcgggacca ccgacagcag caccagcacg gcggccacga cgttcaccac
    16321 cggcgcctgc tgtgggcggg tcatgttgcc gaagatccag atggggaggg tctcgatgcc
    16381 cgggcccgcg gtgaacgtgg tgaccacgat ctcgtcgaag gacagggcga aggcgagcag
    16441 accgcccgcc agcagcgcgg agcggacgag cgggaaggtg acgtccgcga aggcacggaa
    16501 ggtggtcgcg ccgaggtcca tggccgcctc ctcgtacgag gaagcggtac ggcgcagccg
    16561 ggccaccacg ttgttgaaga ccacgacgat gcagaaggtg gcgtgcccga cgatcacggt
    16621 gaacagcccc aggcccacgc cgagcggcgc caggaccgtg ccgaacgccg agttgagggc
    16681 gatccccgtg acgatgccgg gcagcgcgat cggcagcacg acgacgaagg agacggtgtc
    16741 gcggccgaag aagcggtgcc gggccacggc gaaggcgatc agggtgccga ggaccagcgc
    16801 gatggcggtg gctcccagcc ccgccttcac cgagacccac aaagccgcgc gggcaccgga
    16861 gttgtgcgcg gccaccgacc accagtgcag ggtgagcccc ggcggcggcc agctcgcgct
    16921 gcggtcgggg ttcagggagt tgaccaggac gagcagcagt gggacgtaga tcaccgcgaa
    16981 cccgagcccg gcgccgatgc gcagggtgat gcgcgcggtg cggccgagat gcatggcgct
    17041 cttctcctcc aggttctcca ggcgggacta caggctgttc agggcgcccg tgcggcggat
    17101 cgccagcagg tacaggacga tcacggccac cggcacggtg ccgagcgcgg cggccatggg
    17161 caggttgagt tcgatgttgg agtacacgag gttgccgatc agctgcgtct tcccgccgac
    17221 gatctgcacg gtgatgtagt cgccgagact gagcgagaag gtgaacacgg acccggcggc
    17281 gaccgacggc agcaccatcg ggagcaccac cgagcggaag gtccgccccg cccgcgcccc
    17341 gaggtcggcg gacgcgtcga gcaggttggc cgggagctgc tccagggccg tgtggaccgg
    17401 caggatcatg tacggcagcc agaggtaggt cagggtcagg accgtggcgg gcaggccgta
    17461 gccggggccg ctcagcccga gcggcgcgag catccagtcg gcgacgccgc cctcggagag
    17521 gatcagccgc caggcgtaca ccttgaccag gtaactcgcc cacagcgggg tgaggatggc
    17581 cacgaccagc agcggacgcc acctcggccg ggccacgcgt gcggtgtaga aggcgacggg
    17641 gaaggcgatc accgcgcaca gcacggtcac cgcgagggcc accccgacgc tgcgcaggac
    17701 gacctggcgg aagaccggcg tggtgaacag cgcgtggaag ttgtccgtcg accagacctt
    17761 caccacctgg gaggtgaagg agtccgtggt ccagaaggcg gagacgaaca ggaccgccag
    17821 tgagccgagg tagaggacgg tgagccacag cagcggggcg gtgagcagga gggtcaggcg
    17881 cagccggggc atgcggtgca gggctccggc gagccgccgg acggtgcccc ggccggcggc
    17941 ggtaggcgcg tcggtcgtca cgctcagccc ttgatctcgg tccaggcctg cacccacttg
    18001 gcgtacggca cgcacgtgac gtccgtgcgg ccgtccaggc actgctcgat gggcgtgttc
    18061 cagaaggcga tcttcttcca gtagttctcg tcggctgcgt ggtagacggt gcagaagttc
    18121 ttgtccgtgg tctccgcgca cgccttggag ttggccgggg cctcgccgaa gtactcggcg
    18181 acctgggcgt tgaccttcgg ggagacgatc cagtcgagcc atttgtaggc gcaattgggg
    18241 tgcttggcct tggccgagac catccaggtg tcggaccagc cggtcgaacc ctccttcggg
    18301 accagcgcct tgaccttcgc gccctcggcg gcggcgaggt tggcgatgac ctgccaggtc
    18361 gtgccgacca ccgagtcacc gctcttgaag gcggagacct ccttcaggta gtcgctccag
    18421 tactcgccga cgtccgcgtt ctgccgcttg agcagcgcca cggccgcgtc gaactgcttc
    18481 tggtcgaggg cgtacgggtc cttgatcttc aactcgggct tggtggcctt caggtacagg
    18541 gccgcgtccg cgatgtagat cggcgagtcg tacgcggtga cgtgcccctt gtaccgtgcg
    18601 gcgtcgtcga agaccgcgga ccaggaggtg ggggcgggct ggaccttcgc ggtgttgtac
    18661 atcagcaggt tggcgccccg gccgtgcggg atgccgtaca tcttcccccg tacggagttc
    18721 caggcgccgt tcttcagccc gccgaagacg tccttgtagt gggggacgag gccggtgttg
    18781 acgggggcgg cgtcgccgga ggcgatcagg cgcagggagg cgtcgccgga ggcggagacg
    18841 gcgtcgtact cgccggtctt catcagtttg accatctcgt ccgagctggc ggcgaccttg
    18901 gagtggacct ggcagcccgt ccgcttctcg aagccggaga cccagtccac cttggggtcg
    18961 ttggagccgt cctcgacgta gccggcccag gcgatgaggt tgacctggcc ttcggtcttc
    19021 ccgagtttcg tgggggcctt gaggtcgggc gggttgaggc cggtggcgga ggtgctgccg
    19081 gagccggagg agtcgcaggc ggcggcgagc agcagcgcgg cggcgcagac ggccgaggcg
    19141 cgcagggtac gggtgagacg cacggcgttc tccaggggga gggggacggt gtcaggaggg
    19201 caggcggacg gcgtgccggc ggtgccactg gaggcggacc cgggtgccgc ggtaggcggc
    19261 gacgtccgcg gaggaggtct ccaggttctg ctggagcgcg gtgagccggc cgccgccgtc
    19321 caggtcgacc aggaagcggg tggcgtcgcc gaggtagacg acgtcggcga cggtgccggt
    19381 ggcggtggtg tgctcgggct cgtccggctc ggcggcgtcc ttcaggacgc ggatcttctc
    19441 cgggcggatg ttgtaggtgc cgggggagcc ggtgatccgg tgggccgctt cgccttcgag
    19501 gaggttggag gtgccgacga aggaggcgac gaagggggtc gccgggcgct cgtagatctc
    19561 cgcgggggtg ccgacctggg cgatgcggcc cccgtcgaag acggcgatcc ggtcgctcat
    19621 cgtcagggcc tcctcctggt cgtgggtgac gaagacgaag gtgatgccca cttcccgctg
    19681 tagcgccttg agttcgacct gcatctgctc gcgcagcttc aggtcgaggg caccgagcgg
    19741 ctcgtccagc agcagcacgc ggggccggcc gacgagggcc cgggcgagcg cgacgcgctg
    19801 gcgctgcccg cccgacaact gggcgggccg gcgctggccg tagccttcga ggcggacctc
    19861 ggcgagcgcc ttgcgggccc ggaccaggcg ttcggccttc ggtatcctgc ggaccttgag
    19921 cccgtaggcg acgttctgct cgaccgacat gtgcgggaac agcgcgtagt cctggaacac
    19981 ggtgtgcacg tcccgctcga acggggcgag gccggtgacc tcctgcccgg cgagttcgat
    20041 gcggccgtgg tccggtgact cgaacccggc gacgagccgc aggaccgtgg tctttccgga
    20101 gccggacggc ccgagcatcg agaagaactc gccgtcccgg atctccaggt cgaccccggc
    20161 caccgcggtg gtctcgccga acgacttgcg caggccctgc aaccggatcg caattccctc
    20221 catgcgggaa cctttctggc gcgctgaacg ttgaccgcaa acatatgaag tcataggtca
    20281 tagctcaagg tccctttagg gtaaaggttg agtcaacgca cgaggtgatg accgtgaggc
    20341 agcacgagat cgacgcaggg gcccgcaagg cagtcttcag ccccgtggac agccgggccc
    20401 gcgtggacgc ggtcgtccgc cgcatagggg acgccatcga gctgggcctc ctcgccgacg
    20461 gcgagcagct ccccggcgaa agcgaactgg ccggccggct cggcgtctcc acggtcaccc
    20521 tgcgcgaggc gctcatggcc ctgcgacagc agggtctggt caccacccgg cggggccgcg
    20581 gcggaggcag cttcgtctcg ctgcccgaag tccccgccga cgaccggctc aagtcccggc
    20641 tgcgcggctg gagcaccgag gaactgcgcg acctcggcga ccactgggcc gccctgtccg
    20701 gcgccgccgc ccggctcgcc gcccagcgca ccgaacccgc ggacctccag ccgctgcgcc
    20761 ggacggccca ggagctcgcg gaggccgagg acgcgccggc gcgcagccgg ctgtacggcc
    20821 gcttccacgt cgagctcgcc gccgccgccc agtcggcccg gctcacccgg gaacaggtcg
    20881 ggctgcagag cgaggtgggc gccctgctgt gtctggtcct ggccgacgac gcatatcgtg
    20941 aagaagttgc ggagcgtcac cgctcggtcg tctccgccgt gcaagatggg gcccacgaaa
    21001 cggccggcac gctggccgag cggtgcgtca gggagtcgac ggcgcgg
//
