LOCUS       NZ_CP071839            22461 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 7471349
            Orig. end                         :: 7493810
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22461
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lassopeptide"
                     /region_number="30"
                     /rules="(PF13471 and Asn_synthase or micJ25 or mcjC)"
                     /tool="antismash"
     cand_cluster    1..22461
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /kind="single"
                     /product="lassopeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22461
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:12461](+)"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12461
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(PF13471 and Asn_synthase or micJ25 or
                     mcjC)"
                     /neighbourhood="10000"
                     /product="lassopeptide"
                     /protocluster_number="1"
     misc_feature    376..387
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 18.76"
                     /tool="antismash"
     gene            complement(631..1278)
                     /locus_tag="S1361_RS33505"
                     /old_locus_tag="S1361_33485"
     CDS             complement(631..1278)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676241.1"
                     /locus_tag="S1361_RS33505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33485"
                     /product="endonuclease"
                     /protein_id="WP_208035619.1"
                     /transl_table=11
                     /translation="MDRDERVVRELVSEYGRTYAEEAGIRLKDTPQPLYRLLVLSLLLS
                     ARIRASVAVAAARALHEDHLDSPRRMAEADWQQRVDALGRGGYRRYDERTATQLGDGAE
                     LLAERWGGDLRRLHREADGDTGELKRLLQQEPGIGPAGADIFLREAQRVWPDVAPYLDG
                     KALSGAGRLGLPKDPAKLTELAGDTEPAVLAAALVRAALDKQVAEDCLRRAA"
     misc_feature    complement(1264..1277)
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            complement(1292..1636)
                     /locus_tag="S1361_RS33510"
                     /old_locus_tag="S1361_33490"
     CDS             complement(1292..1636)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972181.1"
                     /locus_tag="S1361_RS33510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33490"
                     /product="DUF3140 domain-containing protein"
                     /protein_id="WP_208035620.1"
                     /transl_table=11
                     /translation="MADALEIEALWEDFHRVVNMTSAELAAWLRVRDADEDTEPLPEEA
                     GTPTGQHVLAILQKRRTDLTDDDVRVMHKVVDTVDDLVDMENEPEPENTPEDTRRRHRL
                     MTLGHDPLKP"
     gene            complement(1686..2162)
                     /locus_tag="S1361_RS33515"
                     /old_locus_tag="S1361_33495"
     CDS             complement(1686..2162)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007386226.1"
                     /locus_tag="S1361_RS33515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33495"
                     /product="DNA starvation/stationary phase protection
                     protein"
                     /protein_id="WP_208035621.1"
                     /transl_table=11
                     /translation="MTVVRSTLPEEALGVTGTALQETLVDLLGLSLIGKQAHWNVVGPR
                     FRSIHLQLDEVVAAARDHSDTVAERAAALGVPPDGRPETIAATLALPGAKDGWLRDTEA
                     VELMVSALETAIGRLRERIEATEKADPVTQDLLISVTADLEKQRWMFEAENHPR"
     gene            complement(2246..3055)
                     /locus_tag="S1361_RS33520"
                     /old_locus_tag="S1361_33500"
     CDS             complement(2246..3055)
                     /NRPS_PKS="Domain: Abhydrolase_1 (30-140). E-value:
                     1.7e-21. Score: 68.9. Matches aSDomain:
                     nrpspksdomains_S1361_RS33520_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003972179.1"
                     /locus_tag="S1361_RS33520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33500"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_208035622.1"
                     /sec_met_domain="Thioesterase (E-value: 8.8e-07, bitscore:
                     28.1, seeds: 16, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7e-17, bitscore:
                     61.6, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.5e-16, bitscore: 59.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPHVREHTLDGTHGTLAVHEWPHPAPRRLALLVHGYGEHAGRYAE
                     LARVLTGHGTAVYAPDHAGHGRSAGERVLVEDFEDVVTDVHAVAELARAAHPGLPLVMV
                     GHSMGGLIAARYAQRYGDELSALVLSGPVIGTWELPGRLLALDEIPDLPISPAALSRDP
                     SVGAAYAADPLVWHGPMKRPTLEAFARTLETIARGGDVGRLPLLWLHGDDDRLVPLPGS
                     RTGVERLSGGRPTERIYPGARHEVFNETCKEDVFAELLGFLDRVLPR"
     aSDomain        complement(2636..2965)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S1361_RS33520_Abhydrolase_1.1"
                     /evalue="1.70E-21"
                     /label="S1361_RS33520_Abhydrolase_1.1"
                     /locus_tag="S1361_RS33520"
                     /protein_end="140"
                     /protein_start="30"
                     /score="68.9"
                     /tool="antismash"
                     /translation="LLVHGYGEHAGRYAELARVLTGHGTAVYAPDHAGHGRSAGERVLV
                     EDFEDVVTDVHAVAELARAAHPGLPLVMVGHSMGGLIAARYAQRYGDELSALVLSGPVI
                     GTWELP"
     CDS_motif       complement(2702..2761)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_S1361_RS33520_0001"
                     /evalue="8.60E-05"
                     /label="NRPS-te1"
                     /locus_tag="S1361_RS33520"
                     /protein_end="118"
                     /protein_start="98"
                     /score="15.1"
                     /tool="antismash"
                     /translation="LPLVMVGHSMGGLIAARYAQ"
     misc_feature    3115..3130
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.49"
                     /tool="antismash"
     gene            3198..4385
                     /locus_tag="S1361_RS33525"
                     /old_locus_tag="S1361_33505"
     CDS             3198..4385
                     /EC_number="2.3.1.-"
                     /GO_function="GO:0016746 - acyltransferase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006635 - fatty acid beta-oxidation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1124: acetyl-CoA acetyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019330509.1"
                     /locus_tag="S1361_RS33525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33505"
                     /product="thiolase family protein"
                     /protein_id="WP_208035623.1"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.4e-06, bitscore:
                     26.9, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPVHFAAARRTPIGKLRGALSSVRPDDLAATVIRHLVADVPALD
                     PARIDDVYWGAANQAGEDNRNVARMAVLLAGLPDSVPGATVNRLCASGLEAVTAAARTI
                     AAGEADIVIAGGSESMSRAPFVLPRPDEALPQRIETHDTRLGWRLVNPAMKELHGLLSM
                     GETAEEVAERYGVSRARQDEFALRSHQLAAAARKNGHFDDELLPVERPDGIVVEQDECV
                     REDTSLEKLSRLKPVFRADGTVTAGNASPMNDGAAGLLLVSEEALNELGLESLGRYVAG
                     ASAGVHPDVMGLGPVPATRKVLARAGWETGDLQEAEFNEAFAAQALACVDQLGIDPELV
                     NPTGGAIALGHPLGCSGARILTTLLHRMRRTGAERGLATMCVGVGQGSAVLVERH"
     gene            4461..5972
                     /locus_tag="S1361_RS33530"
                     /old_locus_tag="S1361_33510"
     CDS             4461..5972
                     /NRPS_PKS="Domain: AMP-binding (10-406). E-value: 1.4e-109.
                     Score: 358.3. Matches aSDomain:
                     nrpspksdomains_S1361_RS33530_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676246.1"
                     /locus_tag="S1361_RS33530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33510"
                     /product="long-chain fatty acid--CoA ligase"
                     /protein_id="WP_208035624.1"
                     /sec_met_domain="AMP-binding (E-value: 2.7e-113, bitscore:
                     377.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATLSVAAILAENARRRPGKTALVEGDLRLTFAEVWQRALAQAGA
                     LTGLGVRPGDRVALMAPNTAEFPQAYYAIAAAGGVIVPVHLLLSAGEVEHVLRDSGATL
                     LLVHPAQAETGTAAARATGVRVVTLGGEFEKLAADAEPLGSYVTRVADDPAVVFYTSGT
                     TGVPKGAVLSHFNLVMNATVNAFDANDIRADDIALGALPLFHAFGQTVSLNSTWRAGCT
                     LVLLPRFDAARAIELMVREGVNTFHGVPTMFVALAAAAANADRLPALRVCISGGASLPV
                     AVLERFEAAFATEIYEGYGLSETSPTATVNQPVFGTKPGTIGHPLWGVDVEIARAELED
                     RIELLPPGELGEVVIRGHNVFSGYLGRPEATAEAVVDGWFRTGDLGTKDDEGFLRIVDR
                     KKDVIIRGGYNVYPREVEEVLMRHPEVAQVAVIGLPDDLHGEEVCAVVVPAPGSAPDAA
                     ALTEWSKEHLGRHKYPRRVEVTDGLPLGPSMKVLKRELRTRYASR"
     aSDomain        4491..5678
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S1361_RS33530_AMP-binding.1"
                     /evalue="1.40E-109"
                     /label="S1361_RS33530_AMP-binding.1"
                     /locus_tag="S1361_RS33530"
                     /protein_end="406"
                     /protein_start="10"
                     /score="358.3"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="AENARRRPGKTALVEGDLRLTFAEVWQRALAQAGALTGLGVRPGD
                     RVALMAPNTAEFPQAYYAIAAAGGVIVPVHLLLSAGEVEHVLRDSGATLLLVHPAQAET
                     GTAAARATGVRVVTLGGEFEKLAADAEPLGSYVTRVADDPAVVFYTSGTTGVPKGAVLS
                     HFNLVMNATVNAFDANDIRADDIALGALPLFHAFGQTVSLNSTWRAGCTLVLLPRFDAA
                     RAIELMVREGVNTFHGVPTMFVALAAAAANADRLPALRVCISGGASLPVAVLERFEAAF
                     ATEIYEGYGLSETSPTATVNQPVFGTKPGTIGHPLWGVDVEIARAELEDRIELLPPGEL
                     GEVVIRGHNVFSGYLGRPEATAEAVVDGWFRTGDLGTKDDEGFLRIVDRKKDVIIR"
     CDS_motif       4923..4982
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_S1361_RS33530_0001"
                     /evalue="1.20E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="S1361_RS33530"
                     /protein_end="174"
                     /protein_start="154"
                     /score="24.0"
                     /tool="antismash"
                     /translation="AVVFYTSGTTGVPKGAVLSH"
     CDS_motif       5496..5582
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_S1361_RS33530_0002"
                     /evalue="9.10E-10"
                     /label="NRPS-A_a6"
                     /locus_tag="S1361_RS33530"
                     /protein_end="374"
                     /protein_start="345"
                     /score="30.8"
                     /tool="antismash"
                     /translation="PPGELGEVVIRGHNVFSGYLGRPEATAEA"
     CDS_motif       5649..5711
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_S1361_RS33530_0003"
                     /evalue="6.50E-03"
                     /label="NRPS-A_a8"
                     /locus_tag="S1361_RS33530"
                     /protein_end="417"
                     /protein_start="396"
                     /score="9.4"
                     /tool="antismash"
                     /translation="VDRKKDVIIRGGYNVYPREVE"
     gene            6059..6832
                     /locus_tag="S1361_RS33535"
                     /old_locus_tag="S1361_33515"
     CDS             6059..6832
                     /GO_process="GO:0006810 - transport [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007498637.1"
                     /locus_tag="S1361_RS33535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33515"
                     /product="sulfite exporter TauE/SafE family protein"
                     /protein_id="WP_208035625.1"
                     /transl_table=11
                     /translation="MNTMTLWHTSGWGFAALAFAALLVGFSKTAVSGANTVSLAVFAAV
                     LPARASTGVLLPVLIAGDVLAVLTYRRHAHWPTLWRLFPAVAAGVVAGTLFLVWADDGI
                     VRTSIGAILLLMAGVTVWRRRAAEAPREPDAVTTRAGRVKARAYGVLGGFTTMVANAGG
                     PVMSMYLLSAGFRKLGFLGTSAFFFLIVNVSKVPFSAGLGLIDGRSLLLDAALVVFVVP
                     GALFGKWAVNRINQRLFEQLVIAATVVGGLQLLLR"
     gene            complement(6821..7600)
                     /locus_tag="S1361_RS33540"
                     /old_locus_tag="S1361_33520"
     CDS             complement(6821..7600)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015577189.1"
                     /locus_tag="S1361_RS33540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33520"
                     /product="HAD-IIA family hydrolase"
                     /protein_id="WP_208036882.1"
                     /sec_met_domain="HAD_2 (E-value: 1.8e-06, bitscore: 27.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASVRAVLIDIDGVLTVSWKPLPGAVAALRALRAAGLGVALVTNT
                     TSRTRASIAETLADAGFAVDAEDVLTAPAVTAAHLAEHFPGARCALLNSGDIAADLGDV
                     TLVEEGADVVVIGGAGPGFDYAALNRAFGELQRGARLVAMHRNLYWRTDAGLQLDSGAF
                     LLGLEQAARVTAEVTGKPSRAFFEAALARLGVGAEQALMVGDDIESDVLAAQRAGLTGV
                     LVKTGKYQPATHEQAGGTPDHVLDSFADVPELLGLPQ"
     gene            complement(7839..8627)
                     /gene="cobF"
                     /locus_tag="S1361_RS33545"
                     /old_locus_tag="S1361_33525"
     CDS             complement(7839..8627)
                     /EC_number="2.1.1.152"
                     /GO_function="GO:0043819 - precorrin-6A synthase
                     (deacetylating) activity [Evidence IEA]"
                     /GO_process="GO:0009236 - cobalamin biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cobF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676250.1"
                     /locus_tag="S1361_RS33545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33525"
                     /product="precorrin-6A synthase (deacetylating)"
                     /protein_id="WP_208035626.1"
                     /sec_met_domain="TP_methylase (E-value: 4e-29, bitscore:
                     100.9, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRKIHVIGIGAGDPDQLTLQAVKALRSTDVFFLLDKGEVKSDLTQ
                     LRRDILDAHLPEGSYRVVEARDPERDRKAGGAAYSPAVGDWRSARAGIYERLIGEELDE
                     DGTGAFLVWGDPALYDSTLAILEEVRERGAVEFVYDVVPGISSVSALVARHRTGLNRVA
                     RPVQITTGRRLAEGFPEGVDDVVVMLDAHQAFRRYADEDMDIYWGAYIGTPDEILVSGP
                     IAEAGPRIERLRAEARERKGWIMDTYLLRRHSAQDGQAGG"
     gene            complement(8912..9418)
                     /locus_tag="S1361_RS33550"
                     /old_locus_tag="S1361_33530"
     CDS             complement(8912..9418)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015493397.1"
                     /locus_tag="S1361_RS33550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33530"
                     /product="DUF309 domain-containing protein"
                     /protein_id="WP_208035627.1"
                     /transl_table=11
                     /translation="MTNTGASDARDRDTTGRARNARPRDGLGRPLPYGAEGVPRQPEGV
                     VRTPEETVAEAQALLAQGRPFHAHEVFEDAWKSGPEDERPLWRGLAQLAVGLTHAARGN
                     AVGGARLLRRGAGAVEAWETGQGEDRPYGLDLPGLTRWARELAARVEHGAPPVDPRAEA
                     PRLGP"
     misc_feature    9409..9429
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 20.57"
                     /tool="antismash"
     tRNA            9524..9597
                     /anticodon=(pos:7480907..7480909,aa:Pro,seq:ggg)
                     /inference="COORDINATES: profile:tRNAscan-SE:2.0.12"
                     /locus_tag="S1361_RS33555"
                     /note="Derived by automated computational analysis using
                     gene prediction method: tRNAscan-SE."
                     /old_locus_tag="S1361_33535"
                     /product="tRNA-Pro"
     gene            9524..9597
                     /locus_tag="S1361_RS33555"
                     /old_locus_tag="S1361_33535"
     misc_feature    complement(9820..9833)
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.99"
                     /tool="antismash"
     gene            10001..10651
                     /locus_tag="S1361_RS33560"
                     /old_locus_tag="S1361_33540"
     CDS             10001..10651
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: PF13471"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988888.1"
                     /locus_tag="S1361_RS33560"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33540"
                     /product="lasso peptide biosynthesis B2 protein"
                     /protein_id="WP_208035628.1"
                     /sec_met_domain="PF13471 (E-value: 3.7e-17, bitscore: 61.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQDTGATQHTGATQETDALAALTRILSPHCRVTRLSGGALIADW
                     RRTRFLGMTAADVRTFADQDSEERAELLTGLVRAGCATARRKACTDAEVGLWLRGGHLL
                     IRTLGFGRVLRLLPLLAPDYARTDLPSPADVARLKRVVQAHGRSSWFVNDDCKAQAVTA
                     FILLRRRGFKAVLHVGVREHPFALHAWTTSAGLCIPDADPRGHSFTPVLSIGG"
     misc_feature    complement(10662..10676)
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: medium, score: 23.69"
                     /tool="antismash"
     gene            10662..12461
                     /locus_tag="S1361_RS33565"
                     /old_locus_tag="S1361_33545"
     CDS             10662..12461
                     /GO_function="GO:0004066 - asparagine synthase
                     (glutamine-hydrolyzing) activity [Evidence IEA]"
                     /GO_process="GO:0006529 - asparagine biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lassopeptide: Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677081.1"
                     /locus_tag="S1361_RS33565"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33545"
                     /product="asparagine synthase-related protein"
                     /protein_id="WP_243769390.1"
                     /sec_met_domain="Asn_synthase (E-value: 1.9e-22, bitscore:
                     79.2, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEALRVEFATGAPRLWTAGDMVRRGLVTTVSSPAGTAAVVGWAGP
                     VRDRLAGARALLDAFARPGCEPPLPAGDFAAVLVYRDRVLLMRDRQARIPLFFRESGGR
                     VSAVSTSARGLGSAAELEPRYFCRYSTGNLAQPHTELSPFAGVHRVLGGEVVALSATGW
                     MRGRTRRADDPPAPVADGCAPARELRRALEHAVGRRLGRTVACHVSGGTDSTSVALLAA
                     RLLAVEPGGTGDLVLLGGRFDRGELAGERPYLDEAMAAVRRQAPGARPVIVDADDVADF
                     DDFLHHAGDADEPHAHAFRAPFWSRLHAAAAELGCDTLLTGCGAEPVVDANPFQLHALA
                     RSGQLREMTRQARIRAAASGQGVRDVVRTHVVEPALPLAAERVARLVHRGTVLGGLGPF
                     TRPPWLRRGFARAHGYRAAGAAESRFVFGRTPEQSLYDAANYLAAPDPLSWRCARQNGF
                     FLSHPFLDPEVVATMRRAPAEATFRPGRPKALLREAMADLLPPGIRDRTAKIPFNEPYV
                     RGLRSHGDELIDLCRSARHPLTAEMFDIDTLCQAVREARLGMGDSRSWDRMNGSLALVV
                     WLEGLLDGRAPAPGAAVPVSVAS"
     misc_feature    10663..10677
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 22.1"
                     /tool="antismash"
     gene            complement(12445..13728)
                     /locus_tag="S1361_RS33570"
                     /old_locus_tag="S1361_33550"
     CDS             complement(12445..13728)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014677082.1"
                     /locus_tag="S1361_RS33570"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_33550"
                     /product="hypothetical protein"
                     /protein_id="WP_243769391.1"
                     /transl_table=11
                     /translation="MRIHRRASANSRLRAQRTLARTNRSKVSLASITLVLFASAGLLGW
                     FGIQDFVGALTFAGRITGAVLIAVAFTTLLGAVAVADHWLWHSFRYSGLVALIGTFAAL
                     LTDFLVLAEILKDGDSAFFKTLFGVLTAGSAWAVFSVFRTSVDIPAPKRVAATLIVTTV
                     IAVANFGYQSLYLPSQREVRPVIKLAVGKSMTSPDGTAFSVPVDITIENRSDSAFYVLG
                     SEVHAMAEKVPVTMEDQHEQWRADAEQWAKFEEVNPLSRWEKHEPGELVSAQPWVPFGG
                     WIYANDTFSARVVVQLPMNTNYDQLAFYASAHLTRKDRARVERLGLPSYSWRGAPVPSW
                     VTKHKEVDALVYKSRVHENNAIDETTREPRYLTVYWRFGPHGADLVEAISTEDGTNEPQ
                     EAVEGRYGVRLVETGPVERPLADIKMRR"
     gene            complement(13935..17459)
                     /locus_tag="S1361_RS33575"
                     /old_locus_tag="S1361_33560"
     CDS             complement(13935..17459)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS33575"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_33560"
                     /product="hypothetical protein"
                     /protein_id="WP_208035629.1"
                     /transl_table=11
                     /translation="MSDMLWISVPGGFVHDRPLLRVLVVPRLDGGTPAQHGMAQWPPAA
                     LTSGPVRIELFPPGAGPSATPYGSRDLVPVVPFQAGVWERLVAGLPVEDTVDARRAVDP
                     ARLTVRATSKDAEAVAQGFQDVARAEVDPELGPRSPDFTQRVQRVLRNEHWLGPEEPAP
                     APVAVPASPGRPDFHRTLSLLREHPAVLRALGLVFELTLDPHDVTDHAGGTVRVVWPAR
                     PASLPVVLSPRTLFGAGFRPGSTARVSDGMVTLDRTDDHGAPLWQVATVDVDVAAQRLR
                     EAARAHDAGPAAGPPVLPALRSDGLRLVLRGRGQEMSARLSRAARGTLPDVLTADDLVL
                     GYRIDVRPTLGGAHWFSLHRRNATYRAHRRLPDGRLSEDFLVVGAAGAPEEGHLKSNAA
                     ISDWTGLHADETVAAWRGWSLAVPRPQLDGTPAAQPPAAPGLSLSMAFEVEPGTLPPLR
                     FGRHYTLRARVADLAGGGLGPGDEAAEQHGTRPEFYARHEPLPAPVVGYPAAVDPARVP
                     PGESAELVVIRSDPMADLDVQAYAGRHGYALNDQRLLRPPDGTPALAEQHGMLDVHGDP
                     AVANRVTWEWVRRALLAADSAATGGPALPDPAAGGIAVLRTEPLPPTLLARAWEAPDEW
                     PGLPPRTLQLTTPQPGRPAVAWEGDRLVVRLAPAQQLTLELSTFPREGITDHFALHLAD
                     PPENATKAFGQGRHPMVTPARSLTLVHAVQHPLRRPDTVLKVDRAQNATFAALVPQSDV
                     WDPKSTAEVHVTARWEDQWDTRRQQVTDVPVETIPVDPSGPAHPDTLFRHEFGDTRHRT
                     VTYTLKAVGRFREYFRDPQRADEFTLTKELAPVNVPSSARPAPPVVRSARPAFRWQRTG
                     DLAATGHTLTRVRSAGRIRLALQPPWYTTGTGELLAVVVRPEDTGPGDRLSPFVSVAGG
                     DPVYPTKGLPLGAPFAAHVSSATGPDRRLGLEEAQADVVLKPHQPEYQEDEGCWLCDVA
                     LAGTDGASFHHSLVQLAVARYQPDSLNGLGLSPVVRTDTVPLLPDRTLQVTRLADRYQV
                     KLTGVISPAPAVDRVDMVLERCQAPAGVPADQVDLISFPTSPPGVPAWQREYVLSPAPK
                     KVGLSRVREWTGEFRLPPGTGPVRVRVREVEFIPNDEPREGAFLHTSTPDEIKERTVFT
                     DTVQLPGL"
     gene            complement(17456..20191)
                     /locus_tag="S1361_RS33580"
                     /old_locus_tag="S1361_33565"
     CDS             complement(17456..20191)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS33580"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_33565"
                     /product="hypothetical protein"
                     /protein_id="WP_208035630.1"
                     /transl_table=11
                     /translation="MAGPTFLIVRGEDFVVLAVEWAGCEVRTDAHAAAPRLVATGTDPT
                     VTLTFPPQAILEQATPAEFHTTAAVHSHSWLSEPSRLVFRVATGTVIELTAQGILDALA
                     RPGQAHIDGQASGIELPWGLTVLPLARTTGAQVLSDHRTRPVPVAGSGAVGLWTARLRA
                     GDAGATDALLAIRPTSFRDTDAPPSTDGPFQKPPLRGQRQAIVTSSAQDGPPDATRLEL
                     TALGGTLSAGAQWPSLTWTHEATVGRDQRADVTVSGKLWPFGFSCVYQDFTRREFLPRY
                     DPAAAGCVAALRRQRTLVISRPLLTGTRAPTFPFDEVELLGCEFSLTGTTEPTDFLEFL
                     PGGPSSPVRFPVRCRAGGTTVQFTIPLVFVSDTRPGPSQAVVDSWRPFAKAPVPGVALD
                     LVGAGGRPGDVQEVRSLTFTAAAHGTGYRPDLAGFDVVLSALRTLLPGSGHEQPQPMTY
                     AAALRGQPAAAAVSVPRVPLVFAAPDGLLVDFTRNADRSGGLVAPRFKADGISRELGPV
                     VTDTLPGGTDLAAALERAFKGATLFGFPLAALIDTSGSTKPNPPKIVQRWTGLETSTEM
                     EWQALPLKAYNAFQPATAARLDLSVGSRPPARALPEAAAPPAQTCVLRNVALALPPPPA
                     ARLLTLSFGSVTFDQRPGRPTQLALDAPKIAFSGPLKLLQELQRKLEALLGAGLTCRVS
                     PTGVTVGYEITLPKTAAGMFVMQNVAARLAVTVPYAEKPVTVTLGFASREHPFALSVTG
                     FSGGGYASVEIAGAGEPTVEISMEFGAMVAVDFVVARAEVHALGGVRFVRRADGALELE
                     AFIRIGGSVRLLGLVTVSVELRVALLFHDDGRPSLVGRATLVIELDLTLYSQSVTVDSG
                     TFELVGGIDPGHTALAPEAAEARSAAAFEAWEQYRKAFAS"
     gene            complement(20237..21328)
                     /locus_tag="S1361_RS33585"
                     /old_locus_tag="S1361_33570"
     CDS             complement(20237..21328)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS33585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_33570"
                     /product="hypothetical protein"
                     /protein_id="WP_208035631.1"
                     /transl_table=11
                     /translation="MAPTFDTEIVDKTGTAAGQVSLAVDETNTPWIAYATTGGSVVVAH
                     RDEDGWTRTELPAGPAARDMYRIGLAIDSHERPHVAFANDADDHLIYGRCPDQWTFEEV
                     PSNGGVLTGSVRFVSLRLHPGVFSDAAYKDTPNLAYQSGLNLWHATKAPPKNAPDDPPR
                     WRKNVHKVDGGDLVEKGWFPVLDFDAQETLRIASFDDLSATGQSVRRLRVATRVPGTDF
                     PGQPDSWQVEMLSDPQISGEYPAMGHSITGESFVSYYERTGRTLTLCIFGNFPESPATE
                     AVDKQVVGDDVLSACGVNHNSRICVVYGSGGRLKFATRTGIATFDIQDVEAGGAWSDLV
                     FDRDGSAHIAHMNGSELRYGLAP"
     misc_feature    complement(22213..22233)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 19.2"
                     /tool="antismash"
ORIGIN
        1 gctgcccggt gccagcgcgc cgaccagggt gtccaccagg tcgtgggcgc cgtcctcgtc
       61 ggcgacgaag tgcagcaggg cgatgaggga gagggccacc gggcggtcga ggtccaggac
      121 gcgggcggcc tgttccagga tgctccgcgg atcgcgggcg tcggcctgga cgtactccgt
      181 cacgccctcg ggggtgccgc gcagcagggc gccggcgtgg gccagcacga tggggtcgtt
      241 gtcgacgtag accacgcggg cgtccggggc caccgactgg gcgacctggt gcaggttcgg
      301 ctcggtcggt atgccggtgc cgatgtccag gaactggcgg atgccctgct ccgcggccag
      361 tgcccgggtg gtccggtgca tgaacgcccg gttggcgcgg gcggccttcg gggcgcccgc
      421 gtcgatcgcc gcgatctgcc ggcccagttc ctcgtcgacc gggtagttgt ccttgccgcc
      481 gaggaaccag tcgtacaccc gggccggatg cggccgggtc gtgtcgatga tgtcctggat
      541 ccgcgggccg gtccccgtca cgcgctgctc ctccacccgt ccggtcccgg tgcggtcggt
      601 ccgggacgtg cggggagaag tctgacacga tcatgcggcg cggcgcagac agtcttcggc
      661 cacctgcttg tcgagggccg cccggaccaa cgcggcggcc aggacggccg gttcggtgtc
      721 cccggccagc tcggtcagct tcgccgggtc cttcggcagg ccgagccgcc cggccccgga
      781 cagcgccttg ccgtccaggt agggcgcgac gtccggccac acccgctgcg cctcccgcag
      841 gaagatgtcg gcgccggccg gcccgatgcc cggctcctgc tggagcagcc gcttcaactc
      901 gccggtgtcg ccgtccgcct cccggtgcag ccggcgcagg tcgccgcccc agcgctcggc
      961 cagcagctcg gcgccgtcgc cgagctgggt ggcggtgcgc tcgtcgtacc ggcggtagcc
     1021 gccccggccg agcgcgtcca cccgctgctg ccagtcggcc tcggccatcc ggcgggggct
     1081 gtccaggtgg tcctcgtgca gcgcccgggc ggcggccacc gcgacggagg cccggatccg
     1141 ggcgctgagc agcagggaga gcacgagcag ccggtacagc ggctgcgggg tgtccttcag
     1201 gcggatgccg gcctcctcgg cgtacgtccg cccgtactcg gacaccagct cgcgcacgac
     1261 ccgttcgtcc cggtccatgg tccggctccg gtcagggctt gagcgggtcg tggccgagcg
     1321 tcatcagccg gtgcctgcgc cgggtgtcct ccggcgtgtt ctccggctcg ggctcgttct
     1381 ccatgtcgac caggtcatcg accgtgtcga cgaccttgtg catgacccgg acgtcgtcgt
     1441 cggtgaggtc ggtacggcgc ttctgcagga tggccaggac gtgctgcccg gtgggcgtgc
     1501 ccgcctcctc cggcagtggt tcggtgtcct cgtcggcgtc ccggaccctc agccaggccg
     1561 cgagttccgc cgaggtcatg ttcaccacgc ggtggaagtc ctcccacagc gcctcgatct
     1621 ccagggcgtc ggccatgggt ctcccccttc cgtgcgggag tagtgcctgt tactcggcgt
     1681 ggtcgtcagc gcgggtggtt ctcggcctcg aacatccagc gctgcttctc caggtcggcc
     1741 gtgaccgaga tcagcaggtc ctgggtgacc gggtcggcct tctcggtcgc ctcgatccgc
     1801 tcgcgcagcc ggccgatggc cgtctccagc gccgacacca tcagctcgac ggcctcggtg
     1861 tcgcgcagcc agccgtcctt ggcgccgggc agcgcgaggg tcgcggcgat ggtctccggc
     1921 cggccgtccg gcggcacgcc cagcgcggcg gcccgctccg ccacggtgtc cgagtggtcc
     1981 cgggccgcgg cgaccacctc gtccagctgg aggtggatcg accggaaccg gggtccgacc
     2041 acgttccagt gcgcctgctt gccgatcagc gacaggccca gcaggtcgac cagggtctcc
     2101 tgcagggcgg tcccggtgac gccgagcgcc tcctcgggca gcgtgctcct gaccacggtc
     2161 atgcggtcac gtcccctttc gtgagctgtg cacggtcatg tccgcgggag cgggtgcccg
     2221 ctgcacgggg gagcaaaccg gctgatcagc ggggcagtac ccggtccagg aagcccagca
     2281 gctcggcgaa gacgtcctcc ttgcaggtct cgttgaagac ctcgtgccgc gcccccgggt
     2341 agatccgctc ggtcggccgg ccgccgctca gtcgctcgac cccggtccgg ctgccgggca
     2401 gcggcaccag ccggtcgtcg tccccgtgca gccacagcag cggcagccgg ccgacgtcac
     2461 cgccccgggc gatggtttcc agggtccgtg cgaacgcctc cagcgtcggc cgcttcatgg
     2521 gcccgtgcca gaccagcgga tccgcggcgt acgcggcgcc cacggagggg tcccgggaga
     2581 gcgcggccgg gctgatcggc aggtccggga tctcgtcgag ggccagcagc cgcccgggca
     2641 gctcccaggt gccgatcacc gggccggaca ggacgagcgc gctcagctcg tcgccgtacc
     2701 gctgggcgta gcgggccgcg atcagtccgc ccatggagtg gccgaccatg acgagcggca
     2761 ggccggggtg ggcggcgcgg gccagttccg ccaccgcgtg cacgtccgtg accacgtcct
     2821 cgaagtcctc gacgaggacc cgctcgccgg ccgaacggcc gtggccggcg tggtcgggtg
     2881 cgtacaccgc ggtgccgtgc ccggtgagca cccgcgccag ctccgcgtac cggccggcgt
     2941 gctcgccgta gccgtgcacc aggagcgcca ggcggcgggg ggccgggtgt ggccactcgt
     3001 gtacggcgag ggtgccgtgg gtgccgtcga gggtgtgctc gcggacgtgg ggcatctctc
     3061 ctccaggtgc ctcggtgaag gtcctggggg atcttcccag cggggcggtc ggaggtctat
     3121 agtcgaaaac tagcagtgct aattaactgg tgctgtgcag gtccgtgtcc acagtgtcgt
     3181 aggcaggagc cccagccgtg cgtcccgtcc acttcgcggc cgcccgccgc acccccatcg
     3241 gcaagctgcg cggagcactc tcctccgtcc gccccgacga tctggccgcc acggtgatcc
     3301 gccacctggt ggcggacgtg cccgcgctcg acccggcccg catcgacgac gtctactggg
     3361 gtgccgccaa ccaggccggc gaggacaacc gcaacgtcgc ccggatggcc gtcctgctcg
     3421 ccggactgcc cgactccgtg cccggcgcca ccgtcaaccg gctgtgcgcc tccggactgg
     3481 aggcggtcac cgccgccgcc cgcaccatcg ccgccggcga ggccgacatc gtcatcgccg
     3541 gcggctcgga gtcgatgagc cgcgccccgt tcgtcctgcc ccgccccgac gaggccctgc
     3601 cgcagcgcat cgagacccac gacacccggc tcggctggcg gctggtcaac cccgccatga
     3661 aggagctgca cggcctgctc tccatgggcg agaccgccga ggaggtcgcc gagcggtacg
     3721 gcgtctcccg tgcccggcag gacgagttcg ccctgcgcag ccaccaactc gccgcggccg
     3781 cacggaagaa cggccacttc gacgacgaac tgctccccgt cgagcgcccc gacggcatcg
     3841 tggtcgagca ggacgagtgc gtccgcgagg acacctccct ggagaagctc tcccgcctca
     3901 agccggtctt ccgcgcggac ggcaccgtga cggccgggaa cgcctcgccg atgaacgacg
     3961 gcgcggccgg cctcctgctg gtcagcgaag aggcactgaa cgaactgggc ctggagtccc
     4021 tcggccgcta tgtcgcgggc gcctccgccg gcgtccaccc cgacgtgatg ggcctcggcc
     4081 cggtccccgc cacccgcaag gtgctggccc gggccggctg ggagaccggc gacctccagg
     4141 aggccgagtt caacgaggcg ttcgccgcgc aggccctcgc ctgcgtcgac cagctgggca
     4201 tcgacccgga gctggtcaac cccaccggag gcgccatcgc cctcggccac cccctgggct
     4261 gctccggcgc ccgcatcctc accaccctgc tgcaccggat gcggcgcacg ggcgcggagc
     4321 gcgggctcgc gaccatgtgc gtgggcgtgg ggcagggcag cgcggtgctg gtcgagaggc
     4381 actgacgctc cctccacggg gggctccccg caaggggatc cgttgcaaag agccgcagca
     4441 aggaaacgga gcaccactcc atggcaaccc tgtccgtcgc cgcgatcctc gccgagaacg
     4501 cccggcgccg ccccggcaag accgccctcg tcgaaggcga cctgcggctc accttcgccg
     4561 aggtgtggca gcgggcgctg gcacaggccg gcgcgctcac cggcctcggc gtacggcccg
     4621 gcgaccgggt cgccctcatg gcgcccaaca ccgccgagtt cccgcaggcc tactacgcga
     4681 tcgcggcggc aggcggtgtc atcgtgcccg tgcacctgct gctgtcggcc ggcgaggtcg
     4741 aacacgtcct gcgggacagc ggggccacgc tgctgctggt gcacccggcg caggcggaga
     4801 ccggcacggc cgccgcacgc gccacgggcg tccgagtggt caccctcggc ggcgagttcg
     4861 agaagctcgc ggccgacgcc gagcccctcg gctcgtacgt cacccgggtc gccgacgacc
     4921 ccgccgtcgt cttctacacc agcggcacca ccggtgtccc gaagggcgcc gtcctcagcc
     4981 acttcaacct ggtgatgaac gcgaccgtca acgccttcga cgccaacgac atccgcgccg
     5041 acgacatcgc gctcggcgcg ctgccgctgt tccacgcctt cggccagacg gtgtcgctca
     5101 actccacctg gcgggccggc tgcacgctcg tgctgctgcc ccgcttcgac gcggcccggg
     5161 ccatcgagct gatggtgcgc gagggcgtga acaccttcca cggcgtgccg accatgttcg
     5221 tcgccctcgc ggcggccgcc gccaacgccg atcggctccc cgcactgcgg gtgtgcatct
     5281 ccggcggggc ctcgctgccg gtcgccgtgc tggagcggtt cgaggccgcg ttcgcgacgg
     5341 agatctacga ggggtacggg ctgtcggaga cctcgcccac cgccaccgtc aaccagccgg
     5401 tgttcggcac gaagcccggc accatcggcc acccgctgtg gggcgtcgac gtggagatcg
     5461 cccgcgccga gctggaggac cggatcgagc tgctgccgcc cggcgagctg ggcgaggtcg
     5521 tcatccgcgg ccacaacgtc ttctccggct acctcggccg ccccgaggcc accgccgagg
     5581 ccgtggtgga cggctggttc cgcaccggcg acctcggcac caaggacgac gagggattcc
     5641 tgcggatcgt cgaccgcaag aaggacgtca tcatccgcgg cggctacaac gtctacccga
     5701 gggaggtcga ggaggtcctg atgcgccacc cggaggtcgc ccaggtcgcc gtcatcggcc
     5761 tgcccgacga cctgcacggc gaggaggtgt gcgccgtcgt cgtcccggcg ccgggcagcg
     5821 cccccgacgc cgccgcgctc accgagtggt ccaaggagca cctcggccgg cacaagtacc
     5881 cgcggcgcgt ggaggtcacc gacggactgc cgctcgggcc gagcatgaag gtgctcaagc
     5941 gggagctgcg gacgcggtac gcgagccgtt aggcggtacg ccctagccgt cgcacgggac
     6001 cgaacggcga gacgctcctt acgacacacc catgcatgtg catagcatcg gttcctccat
     6061 gaacacgatg acgctctggc acacgtccgg ctgggggttc gcggcgctcg ccttcgcggc
     6121 cctgctcgtc ggcttctcca agaccgcggt cagcggggcc aacacggtca gcctcgcggt
     6181 cttcgccgcg gtcctgcccg cccgcgcctc gacgggcgtg ctgctgcccg tgctgatcgc
     6241 cggcgacgtg ctcgccgtgc tcacctaccg gcggcacgcg cactggccca cgctgtggcg
     6301 gctgttcccg gccgtcgcgg cgggcgtggt ggccggcacg ctgttcctgg tgtgggccga
     6361 cgacgggatc gtacggacct cgatcggcgc gatcctgctg ctgatggccg gggtgacggt
     6421 gtggcgccgg cgggccgcgg aggccccgcg ggagccggac gcggtgacga cccgggcggg
     6481 ccgggtgaag gcgcgcgcgt acggggtgct cggcgggttc acgacgatgg tcgccaatgc
     6541 gggcggaccg gtgatgtcga tgtacctgct gtccgccggc ttccggaagc tcggcttcct
     6601 tggcacctcc gccttcttct tcctcatcgt gaacgtgtcg aaggtgccgt tcagcgcggg
     6661 tctggggctg atcgacgggc gctcgctgct cctcgacgcc gcgctcgtgg tgttcgtcgt
     6721 gcccggcgcg ttgttcggca agtgggctgt gaaccggatc aaccagcgac tcttcgaaca
     6781 actcgtgatc gcggcgacgg tcgtaggcgg cctgcaactg ctactgcggt agccccagca
     6841 gctccggaac gtccgcgaag gagtccagga cgtggtccgg ggttccgccg gcctgctcgt
     6901 gcgttgccgg ctggtacttg cccgtcttca ccagcacccc cgtcagcccg gcccgctgcg
     6961 ccgccagcac gtccgactcg atgtcgtcgc cgaccatcag cgcctgctcg gcgcccaccc
     7021 ccagccgggc cagcgccgcc tcgaagaacg cccgggacgg cttgcccgtg acctccgccg
     7081 tcacgcgcgc cgcctgctcc agaccgagca ggaaggcacc cgagtccagc tgcagccccg
     7141 cgtcggtccg ccagtacagg ttgcggtgca tggcgaccag ccgcgcgccc cgctgcagct
     7201 cgccgaacgc ccggttcagc gccgcgtagt cgaacccggg cccggcgccg ccgatcacga
     7261 ccacgtcggc accctcctcg acgagcgtga cgtcccccag gtccgcggcg atgtccccgc
     7321 tgttcagcag cgcgcagcgg gcgcccggga agtgctcggc gagatgggcg gcggtgacgg
     7381 ccggcgcggt cagcacgtcc tcggcgtcca cggcgaaacc ggcgtccgcc agcgtctcgg
     7441 cgatcgacgc ccgggtccgg gaggtcgtgt tggtcaccag ggccacgccg agcccggccg
     7501 cgcggagcgc gcgcagcgcc gccaccgcgc cgggcagcgg cttccaggac acggtgagga
     7561 ccccgtcgat gtcgatcagg acggcacgca cggacgccat ggattccatg gaccgaccgt
     7621 agcgacccga ccggcgcccg cacgggtacg accgcgcacg ctcacccctg tgcccgcgcg
     7681 ccgacagcgc ccgggccgtc ggggcggccg cgccctgccg ccccgtgggt gtggcggttg
     7741 ccgtgtgggt ctcgcggtca ccgtgccctg cgggtcccgt ggtccccgtg ccctgccgga
     7801 ccctggcccc ggcggtcgcc gaggccgtcc cgcgccggtc agccccctgc ctggccgtcc
     7861 tgcgcggaat gccggcgcag caggtacgtg tccatgatcc agcccttgcg ctcccgggcc
     7921 tccgcccgca gccgctcgat gcgcggaccg gcctcggcga tcggaccgga gacgaggatc
     7981 tcgtccggcg tgccgatgta ggcgccccag tagatgtcca tgtcctcgtc ggcgtaccgc
     8041 cggaaggcct ggtgcgcgtc cagcatcacg accacgtcgt ccaccccctc cgggaagccc
     8101 tcggccagcc gtcgcccggt ggtgatctgc accggccggg cgacccggtt cagccccgtg
     8161 cgatgccggg cgaccagcgc ggagacactg ctgatgccgg gcaccacgtc gtacacgaac
     8221 tccaccgcgc cccgctcgcg cacctcctcc aggatggcca gcgtgctgtc gtacagcgcc
     8281 ggatcacccc acaccaggaa ggcgccggtg ccgtcctcgt ccagctcctc gccgatcagg
     8341 cgctcgtaga tcccggcgcg ggcgctgcgc cagtccccga cggccggcga ataggccgcc
     8401 ccgcccgcct tccggtcccg ctccgggtcc cgggcctcca ccacccggta cgacccctcg
     8461 ggcaggtgcg cgtccaggat gtcccggcgg agctgggtca gatcgctctt cacctcgccc
     8521 ttgtcgagca ggaagaacac gtccgtgctc cgcagcgcct tgaccgcctg cagggtcagc
     8581 tggtcggggt cgcccgcgcc gataccgatg acatgaatct ttcgcacgac ccgagtctgc
     8641 cgcacgcccc ggagcccccc tccaccgcct gggcacatgc tgcgtccgat gccggggcgg
     8701 ggggtgcggt gggggcgcct cggcgcatac cgaggcatgt cccggttcgg ggtgcggtgc
     8761 ggggtcgcgg cttgcggggc cgccgtctcg gtgctgggac cgcccctggg ccgacgaggg
     8821 gccggccgcg gcacccccgc ccctgggtgc ggctgcgtcc gggttctcgg gcggggcggg
     8881 ggcctcggcg tgtggtgtgt ccgggcccgg gtcaggggcc cagccggggt gcctcggctc
     8941 gtgggtccac cgggggagcg ccgtgctcca cccgggcggc cagttcccgc gcccagcggg
     9001 tgagccccgg cagatccagc ccgtacggcc ggtcctcgcc ctgcccggtc tcccacgcct
     9061 cgaccgcgcc ggcgccccgc cgcagcagcc gcgccccgcc gacggcgttc ccgcgggccg
     9121 cgtgggtgag acccaccgcc agctgggcga gcccccgcca cagcgggcgc tcgtcctcgg
     9181 ggcccgactt ccaggcgtcc tcgaacacct cgtgcgcgtg gaacggccgc ccctgggcca
     9241 gcagcgcctg cgcctcggca acggtctcct ccggcgtccg cacgaccccc tccggctgcc
     9301 gcggaacccc ttcggcgccg tacggcagcg ggcgccccag tccgtcccgg ggccgcgcgt
     9361 tccgggcccg cccggtcgtg tcccggtccc tggcgtccga tgcgcccgtg ttcgtcatac
     9421 cgccgattgt ccccccgccc cgccgggcct tcttcggcac accccccggc gtggggtaaa
     9481 gtgctgtccg caccatcacg cggggcaccg cgggtgaggg caacgggacg tggcgcagct
     9541 tggtagcgca cttgactggg ggtcaagggg tcgcaggttc aaatcctgtc gtcccgacgg
     9601 gagcaacgct ccgtagtcgc aggtcaaagg gctctgcccc gcacagcggg gtggggccct
     9661 cgatcatgtt ccggggcttg tgccacccga tacctcgggc cacacgtcga gcggacggac
     9721 ggctcgtcga ctccgttgtg cctgcgcgcg cgggacttgg gcctgctccg gcggttgagg
     9781 accacggttg cgaggtgttc ggggcagagt agcctggagt tgatcggcgc cactcttttc
     9841 tggaggtagg cgatgttgat ccgactgctg cggcttcgta tgccgcgtgg gcttgttctt
     9901 ctcggcggcg gccgcctgat ccggggtttc agcggcggcg actacgacgg tcacggatat
     9961 cagtcctgac accgtgcacc ggcgcagggg aggttgtgcg gtgacacagg acaccggcgc
    10021 cacgcagcac accggcgcga cacaggagac cgacgccctg gcggccctga cgcggatcct
    10081 ctcgccgcac tgccgggtca ccaggctctc cggcggggcg ctcatcgccg actggcggcg
    10141 gacgcggttt ctcggcatga cggcggcgga cgtccgcacg ttcgccgacc aggactccga
    10201 ggaacgcgcg gaactcctca ccggtctcgt ccgagccggc tgcgccacgg cccgccgcaa
    10261 ggcgtgcacg gacgccgagg tcggactctg gctgcgcggc gggcacctgc tgatccggac
    10321 gctgggtttc gggcgcgtcc tgcgcctcct gcccctcctc gcccccgact acgcccggac
    10381 ggacctccct tcccctgcgg acgtggcacg gctgaagcga gtggtccagg cacacggccg
    10441 cagcagctgg ttcgtcaacg acgactgcaa ggcccaggcc gtcacggcgt tcatcctgct
    10501 gcggcggcgc ggtttcaagg ccgtcctgca tgtcggtgtg cgcgagcacc cgttcgccct
    10561 gcacgcctgg acgacctcgg ccggcctgtg catcccggac gccgatccgc gagggcactc
    10621 cttcacaccg gttctctcga tcggtggttg agggcgtcga cgtggaagcg ctccgagtcg
    10681 agttcgccac gggcgcgccc cggctctgga cggccgggga catggtccgg cggggcctgg
    10741 tgacgacggt gtcgtccccg gccggcaccg ctgcggtcgt cggctgggcc ggcccggtcc
    10801 gcgaccgcct ggccggtgcg cgcgccctcc tcgacgcctt cgcccgcccg ggctgtgaac
    10861 cgccgctgcc cgccggagac ttcgcggccg tcctcgtgta ccgggaccgc gtcctgctga
    10921 tgcgggaccg gcaggcacgc atcccgttgt tcttcaggga gtccggtggc cgggtgagcg
    10981 cggtgagcac gtcggcgcgc ggcctgggca gcgccgccga gctggaaccc cgctacttct
    11041 gccggtactc gaccggcaac ctggcgcaac cgcacacgga gctgagcccg ttcgcggggg
    11101 tgcaccgggt cctgggcggc gaggtggtgg cgctctcggc caccgggtgg atgcgcggcc
    11161 gcacccggcg cgccgacgac ccgccggcac cggtggcgga cggatgcgct cccgcgcggg
    11221 agctgcgccg cgcactggag cacgccgtcg ggcgccgcct cggcaggacg gtcgcctgcc
    11281 atgtctccgg tggcaccgac tccaccagcg tcgcgttgct cgccgcccgc ctgctcgccg
    11341 tggaaccagg cggcaccgga gacctggtgc tgctcggcgg gcgcttcgac cggggagagc
    11401 tggccgggga gcggccgtac ctcgacgagg cgatggcggc ggtccgccgg caggcacccg
    11461 gcgcccgtcc ggtgatcgtc gacgccgacg acgtggccga cttcgacgat ttcctgcacc
    11521 acgccggaga cgccgacgag ccccatgccc acgccttccg cgcccccttc tggagccggc
    11581 tgcacgccgc ggcggcggag ctgggctgcg acaccctcct gaccggatgc ggagccgagc
    11641 cggtcgtgga cgccaacccg ttccagctgc acgcgctggc ccggtccgga cagctgaggg
    11701 agatgacacg tcaggcacgg atccgggcag cggcgagcgg acaaggagtg cgtgacgtcg
    11761 tccgcaccca cgtcgtggag ccggcgctgc cgctggcagc cgaacgggtc gccaggctcg
    11821 tccaccgcgg aacggtcctc gggggcctgg gccccttcac ccgaccgccc tggctgcgac
    11881 gcggattcgc gcgggcgcac ggctaccgcg cggccggcgc cgcggagagc cgcttcgtgt
    11941 tcggacgcac gccggaacag tcgctctacg acgcggccaa ctacctcgcc gcgcccgacc
    12001 cgctgtcctg gcgctgcgcg cgacagaacg gattcttcct ctcgcatccc ttcctcgacc
    12061 cggaggtcgt cgcgacgatg cgccgcgccc ccgccgaagc cacgttccgc ccgggccggc
    12121 cgaaggcgct gctgcgcgag gccatggccg acctcctgcc gcccgggata cgggaccgaa
    12181 cggcgaagat tcccttcaac gagccgtacg tccgtggtct gcggtcgcac ggcgacgaac
    12241 tgatcgacct ctgccgctcc gcacggcatc cgctcaccgc ggagatgttc gacatcgaca
    12301 cgctctgcca ggcggtgcgg gaggctcggc tgggcatggg cgactcccgc tcctgggacc
    12361 gtatgaacgg ctcgctcgcc ctggtggtgt ggctggaggg actgctggac ggacgcgccc
    12421 cggcacccgg cgcggccgtc ccggtcagcg tcgcatcttg atgtccgcga ggggccgttc
    12481 gaccgggccc gtctcgacca gccggacgcc gtaccggccc tccaccgctt cctggggttc
    12541 gttcgtcccg tcctccgtgc tgatggcttc caccaagtcg gcgccatggg ggccgaaccg
    12601 ccagtagacg gtcaggtagc ggggctccct cgtcgtctcg tcgatcgcgt tgttctcgtg
    12661 gacccggctc ttgtagacga gggcgtcgac ctccttgtgc ttcgtcaccc atgagggcac
    12721 cggggcgcca cgccagctgt acgacgggag gccgaggcgc tccacacgag cgcggtcctt
    12781 gcgtgtcagg tgcgcgctgg catagaacgc gagctggtcg tagttggtgt tcatgggaag
    12841 ttgcacgaca acccgggcgg agaacgtgtc gttggcgtag atccatcctc cgaagggcac
    12901 ccacggctgt gccgacacca actcgccggg ctcgtgtttc tcccagcgtg agagcggatt
    12961 gacttcctcg aacttcgccc actgctcggc atcggcccgc cactgctcat gctggtcctc
    13021 catggtgacc ggcacctttt ccgccatggc gtggacctca ctgcccagaa cgtagaaggc
    13081 cgagtcgctc cggttctcga tcgtgatgtc caccgggacg gagaacgccg tgccatccgg
    13141 actcgtcatc gactttccca ccgccagctt gatgacgggc cggacctcgc gctgggacgg
    13201 cagatagagg ctctggtagc cgaagttcgc cacggcgatg accgtggtga cgatcagtgt
    13261 cgcggccacc cgcttgggag cggggatgtc gaccgatgtg cggaacaccg agaagacggc
    13321 ccatgccgag cccgccgtga ggacaccgaa cagggtcttg aagaaggccg aatcgccgtc
    13381 cttcaggatc tcggccagga cgaggaagtc ggtcagcagg gccgcgaacg tgccgatcag
    13441 tgccacgaga ccggagtagc ggaagctgtg ccacagccag tggtccgcga ccgcgacggc
    13501 gcccagcagc gtcgtgaacg ccacggcgat gagcacggcg ccggtgatgc gaccggcgaa
    13561 ggtcagcgcc ccgacgaagt cctggatgcc gaaccagccc aacagcccgg ccgacgcgaa
    13621 cagtaccagc gtgatcgacg ccagggacac cttcgacctg ttggtcctcg ccagcgtccg
    13681 ctgggcccgc aggcgagagt tggcggacgc gcggcggtgg atcctcacgc gaccaccgcc
    13741 ggtaagagtc gcaccggtcc ggaccggccc gtgcccaggt gttccacggc gtgcctcctc
    13801 cgcagacccg cggcggacca ggagactgcc accggggatg cgtactcatc ctccgtggtg
    13861 atcggcccgc ccgccatcca cgtgcctccg gatgcgggag tacggggacg tgcgcgcgtc
    13921 gggggagggg ccggtcagag accgggcagc tggaccgtgt ccgtgaacac ggtccgttcc
    13981 ttgatctcgt ccggtgtgga ggtgtgcagg aacgcgccct cgcggggttc gtcgttgggg
    14041 atgaactcga cctcgcggac gcgtacccgg acgggcccgg tgcccggggg caaccggaac
    14101 tcgcccgtcc actccctgac ccgcgacagg cccaccttct tcggggccgg gctgagcacg
    14161 tactcacgct gccatgccgg aaccccggga gggctcgtgg ggaaggagat gaggtcgacc
    14221 tggtccgccg gcacgcccgc cggcgcctgg cagcgttcca ggaccatgtc gacccggtcg
    14281 accgcggggg ccggcgagat cactccggtc agtttcacct ggtaccggtc ggcgaggcgc
    14341 gtcacctgga gcgtccggtc gggcagcagg ggcacggtgt ccgtcctgac caccggcgac
    14401 agcccgagac cgttcaggct gtcgggctgg tagcgggcga cggcgagctg caccagcgag
    14461 tggtggaagg acgcaccgtc cgttcccgcg agcgccacgt cgcacagcca gcagccctcg
    14521 tcctcctggt actccggctg gtgcggtttg aggacgacgt cggcctgggc ctcctccagc
    14581 cccaggcgcc ggtccggtcc cgtggcgctg gagacgtggg cggcgaacgg cgcgccgagg
    14641 ggcaggccct tggtggggta gaccgggtcg ccgccggcca cggagacgaa cggggagagc
    14701 cggtcacccg ggccggtgtc ctccgggcgg accaccaccg cgagcagctc gccggtcccg
    14761 gtggtgtacc agggcggttg caaggccagc cggatacggc cggccgagcg cacccgggtg
    14821 agcgtgtggc ccgtcgccgc gaggtcgccg gtccgctgcc agcggaacgc cggccgggcg
    14881 gaccggacca ccgggggcgc cggccgcgcc gaactcggca cgttcaccgg cgccagctcc
    14941 ttggtcaggg tgaactcgtc ggcccgctgg ggatcgcgga agtactcccg gaaccggccg
    15001 accgctttga gcgtgtacgt cacggtgcgg tgccgggtgt cgccgaactc gtggcggaag
    15061 agggtgtccg ggtgcgccgg gccggacggg tcgaccggga tcgtctcgac gggcacatcg
    15121 gtcacctgct gccgccgggt gtcccactgg tcctcccagc gggcggtgac gtgcacctcc
    15181 gccgtgctct tcggatccca cacgtcggac tgcggcacca acgcggcgaa ggtggcgttc
    15241 tgggcacggt ccaccttcag gacggtgtcg gggcgccgca gcggatgctg caccgcgtgg
    15301 acgagcgtga gggaccgggc cggcgtgacc atcgggtgcc ggccctgccc gaacgccttg
    15361 gtcgcgttct ccggcgggtc ggccaggtgc agggcgaagt ggtcggtgat gccctcccgg
    15421 gggaacgtcg acagttccag ggtcagctgc tgcgccggcg ccagacggac gaccagccgg
    15481 tcaccctccc acgccacggc gggccgcccg ggctgtgggg tggtcagctg cagcgtcctg
    15541 ggcggcaggc cgggccactc gtccggggcc tcccaggccc gggccagcag ggtgggcggg
    15601 agcggctcgg tgcgcaggac ggctatgccg ccggcggccg gatccggcag ggccggtccc
    15661 ccggtcgccg cggaatccgc cgccaggagc gcccgcctga cccattccca ggtcacgcgg
    15721 ttcgccacgg ccggatcgcc gtgcacatcg agcatgccgt gctgttcggc gagggccggt
    15781 gtgccgtccg gtggccgcag cagccgctgg tcgttcagcg cgtagccgtg gcgtccggcg
    15841 tacgcctgga cgtccaggtc cgccatgggg tcgctgcgga tcaccaccag ctcggccgac
    15901 tcgcccggcg gtacccgggc ggggtccacg gccgcggggt acccgacgac cggtgctggc
    15961 agcggctcgt ggcgggcgta gaactcgggc cgggtcccgt gctgctcggc cgcctcgtcc
    16021 ccggggccga gcccgccgcc cgccaggtcg gccacgcggg cccggagcgt gtagtggcgc
    16081 ccgaagcgca gcgggggcag ggtgccgggc tcgacctcga aggccatgct gaggctgagc
    16141 cccggggcgg ccggcggctg cgcggccggt gtcccgtcga gctggggccg gggcaccgcc
    16201 aggctccagc cccgccaggc ggccacggtc tcgtccgcgt gcagcccggt ccagtcgctg
    16261 atggcggcgt tggacttgag gtggccctcc tccggtgcgc ccgccgcgcc gacgacgagg
    16321 aagtcctcgc tcagccggcc gtcgggcagc cgccggtggg cccggtaggt ggcgttgcgc
    16381 cggtgcagcg agaaccagtg ggcgccgccg agggtgggcc gtacgtcgat gcggtagccg
    16441 agcaccaggt cgtccgccgt gaggacgtcc ggcagcgtcc cccgggccgc tctgctcagc
    16501 cgtgcgctca tctcctggcc gcggccgcgc agcaccagcc gcaggccgtc cgagcgcagg
    16561 gcggggagca ccggggggcc ggcggccggg ccggcgtcgt gggcgcgggc cgcttcgcgc
    16621 agccgctggg cggcgacgtc cacgtcgacg gtcgccacct gccacagcgg cgccccgtgg
    16681 tcgtcggtcc ggtccagggt gaccatgccg tcgctcaccc gggccgtcga gccgggacgg
    16741 aaccccgctc cgaacagggt gcgcggcgag aggacgacgg gcagcgacgc gggccgtgcg
    16801 ggccacacca cgcgcacggt cccgccggcg tggtcggtga cgtcgtgcgg atcgagcgtc
    16861 agctcgaaga ccaggcccag ggctcgcagg acggccgggt gctcccgcag cagcgacagg
    16921 gtccggtgga agtccggccg ccccggggag gcgggtacgg ccacgggggc gggcgccggt
    16981 tcctcggggc ccagccagtg ctcgttgcgc agcacccgct gcacccgctg ggtgaagtcc
    17041 ggtgaccgcg ggcccagttc cgggtccacc tcggcccgcg ccacgtcctg gaacccctgg
    17101 gccaccgctt ccgcgtcctt cgaggtcgcc cgcacggtca gccgggcggg gtccacggcc
    17161 cgccgcgcgt cgacggtgtc ctcgaccggc agcccggcga ccagccgctc ccagacgccg
    17221 gcctggaacg ggacgacggg aacgaggtcc cggctgccgt acggggtggc ggacggcccc
    17281 gcacccggcg ggaacagctc gatgcgtacc gggcccgacg tcagggccgc cggcggccac
    17341 tgcgccatgc cgtgctgcgc cggcgtgccg ccgtcgagcc ggggcacgac gagcacccgc
    17401 agcagcgggc ggtcgtgcac gaagccgccg ggtacggaga tccacagcat gtcgctcatg
    17461 acgcgaacgc cttccggtac tgctcccagg cctcgaacgc cgccgcggag cgcgcctcgg
    17521 ccgcttcggg ggcgagggcg gtgtggccgg ggtcgatgcc gccgacgagt tcgaaggtcc
    17581 cgctgtcgac ggtgaccgac tgcgagtaga gcgtcaggtc cagctcgatg acgagggtcg
    17641 cccggcccac caggctcggc cggccgtcgt cgtggaagag cagggcgacc cgcagctcga
    17701 ccgagaccgt caccaggccg agcagccgca cgctgccgcc gatccggatg aacgcctcca
    17761 gctccagcgc gccgtcggcc cggcgcacga agcgcacccc gcccagcgcg tggacctcgg
    17821 ccctggcgac cacgaagtcg acggcgacca tcgcgccgaa ctccatcgag atctccaccg
    17881 tcggctcgcc cgcaccggcg atctccaccg aggcgtaccc gccgccgctg aacccggtga
    17941 cggagagggc gaaggggtgt tcccggctcg cgaacccgag cgtcacggtc accggtttct
    18001 ccgcgtacgg aacggtcacc gccagccgcg ccgccacgtt ctgcatgacg aacatgccgg
    18061 ccgccgtctt cggcagcgtg atctcgtagc cgacggtgac cccggtgggg gagacccggc
    18121 aggtgaggcc tgcgccgagg agcgcctcca gcttgcgctg cagctcctgg agcagcttca
    18181 gcggaccgct gaacgctatc ttcggcgcgt ccagggcgag ctgcgtcggg cggcccggcc
    18241 gctggtcgaa cgtcaccgag ccgaaggaca gcgtcagcag ccgtgcggcg ggcggcgggg
    18301 gcagcgcgag ggcgacgttg cgcagcacac aggtctgcgc gggcggagcg gccgcctccg
    18361 gcagggcccg ggccggcggg cgggagccga cggacaggtc cagtcgcgcg gccgtcgccg
    18421 gctggaaggc gttgtacgcc ttgagcggga gtgcctgcca ctccatctcc gtgctggtct
    18481 ccagccccgt ccaccgctgc acgatcttcg gcgggttggg cttggtgctc cccgaggtgt
    18541 cgatgagagc ggccagcggg aagccgaaca gcgtcgcccc cttgaaggcc ctctccagtg
    18601 ccgccgccag gtcggtgccg cccgggaggg tgtcggtgac gacggggccc agctcgcggg
    18661 agatcccgtc ggccttgaac ctgggcgcca cgagccctcc ggagcggtcg gcgttcctgg
    18721 tgaagtcgac caggagaccg tccggcgcgg cgaagaccag ggggacccgg ggcacggaca
    18781 ccgcggcggc ggcgggttgg ccgcgcagtg cggcggcgta ggtcatgggc tgcggctgct
    18841 cgtgccccga gccgggcagc aaagtgcgca gagcggacag gacgacgtcg aacccggcca
    18901 ggtccgggcg gtacccggtg ccgtgcgccg cggcggtgaa cgtcagcgac cggacctcct
    18961 ggacgtcccc cggcctgccg cccgccccca ccaggtcgag ggcgacgccg gggaccggtg
    19021 ccttggcgaa cggacgccag ctgtccacca ccgcctgcga cgggcccggc cgtgtgtcgg
    19081 agacgaagac cagcggaatg gtgaactgca cggtggtccc gccggcgcgg cagcggaccg
    19141 ggaaacgcac gggcgaggag gggccgcccg gcaggaactc caggaagtcc gtcggctccg
    19201 tggtgccggt gagggagaac tcgcagccca gcagctccac ctcgtcgaac gggaacgtcg
    19261 gggcgcgggt gcccgtcagg agcggccggg agatcaccag ggtgcgctgc ctgcgcaggg
    19321 ccgccacaca gccggcggcg gccgggtcgt accgggggag gaactcccgc cgggtgaagt
    19381 cctggtacac gcaggagaag ccgaacggcc agagtttccc cgacacggtg acgtcggccc
    19441 gctggtcccg gccgaccgtc gcctcgtggg tccaggtcag cgagggccac tgcgcaccgg
    19501 ccgacagggt gccgcccagc gcggtcagct ccagccgggt ggcgtcgggc ggcccgtcct
    19561 gggcgctcga cgtgacgatg gcctgccgct ggcctctcag cggcggcttc tggaacgggc
    19621 cgtcggtcga gggcggggcg tcggtgtccc ggaaggaggt ggggcggatc gccaggaggg
    19681 cgtccgtggc gccggcgtcg ccggcccgca accgcgcggt ccacaggccc accgcacccg
    19741 aacccgccac cggcaccggc cgcgtccggt ggtccgacag cacctgcgcg cccgtggtcc
    19801 gggccagggg aaggacggtg agtccccacg gcagctcgat cccggaggcc tgtccgtcga
    19861 tgtgcgcctg cccggggcgg gcgagcgcgt cgaggatgcc ctgcgcggtc agctcgatca
    19921 cggtgcccgt cgcgacccgg aagacgagcc ggctgggttc ggacagccac gagtgactgt
    19981 gcacggcggc ggtggtgtgg aactcggccg gtgtggcctg ctccaggatc gcctgcggcg
    20041 ggaaggtgag cgtcacggtc gggtcggtac cggtggccac cagcctcggc gcggcggcat
    20101 gcgcgtccgt acggacctcg catccggccc attcgacggc caggacgacg aagtcctcac
    20161 cgcgtacgat cagaaaggtc ggccccgcca tcactcacca cccgcttcgt cgccgcggtc
    20221 ccgcgcctca tgcgcctcat ggcgccaggc cgtaccggag ctcgctgccg ttcatgtgcg
    20281 cgatgtgcgc gctgccgtcg cggtcgaaga cgaggtcgct ccacgctccg ccggcctcga
    20341 cgtcctggat gtcgaaggtg gcgatgccgg tccgcgtcgc gaacttcagc cggcctccgg
    20401 agccgtagac cacacagatc cgcgaattgt ggttcacccc gcacgcggag agcacgtcgt
    20461 ccccgaccac ctgcttgtcg acggcttccg tggccgggga ttccgggaag ttgccgaaga
    20521 tgcagagtgt gagcgtgcgc ccggtccgtt cgtagtacga gacgaagctt tcgccggtga
    20581 tcgagtgccc catcgcgggg tactcgccgc tgatctgagg gtcgctcagc atctccacct
    20641 gccagctgtc cggctggccc gggaagtcgg ttccgggcac ccgggtcgcc acgcgcagcc
    20701 tgcggacgga ctggccggtg gcggacaggt cgtcgaagga ggcgatgcgc agcgtctcct
    20761 gggcgtcgaa gtccagcacc gggaaccagc ccttctccac gaggtccccg ccgtcgacct
    20821 tgtgcacgtt cttcctccag cgcggaggat cgtccggtgc gttcttcgga ggcgccttgg
    20881 tggcgtgcca gaggttgagg ccggactggt aagcgaggtt gggggtgtcc ttgtacgcgg
    20941 catcactgaa caccccgggg tgcagccgga gcgagacgaa ccgcacgctg ccggtgagga
    21001 cgcccccgtt gctggggacc tcctcgaagg tccactggtc ggggcacctg ccatagatca
    21061 ggtggtcgtc ggcatcgttc gcgaaggcga cgtgcggcct ctcgtgggag tcgatcgcga
    21121 ggccgatgcg gtacatgtcg cgggccgccg gccccgccgg cagttccgtc ctggtccacc
    21181 cgtcctcgtc ccggtgggcc acgacgacgc tcccgccggt ggtcgcgtac gcgatccagg
    21241 gtgtgttcgt ctcgtcgacc gccagggaca cctggccggc agcggtgccg gtcttgtcca
    21301 cgatctcggt gtcgaatgta ggcgccatgt tcctcgtcat ctccgattga atgcttgccc
    21361 gttagttgtc acgtgttcaa tcgagaggga tgcgcgccgc ggactcgctc actcacacgc
    21421 tagtcaccgc gagggcgtgc tgcaccccga aggatccggg ctgcgcgagt ccgttcgcgg
    21481 gagcaggatg gatgcggggg gatgcaacgt tggctccggc gtcggcctct gaggagacga
    21541 ccatggaatc gggcaggatc gagcgcaacc ccctggcacc ggaacccgcg ccggcgccgc
    21601 gagccggcca ggagctggaa cgcgaggcgg ccgaacggct cgacgagatc cggcagtact
    21661 tcaaggaccg gtacgcgcgc cgcgacgtcg tcgcccgcac caccacggcc accggtgagg
    21721 aactcgactg ggttccggcc ggttcccacg cggagccccc cgacctggag gggccgcagc
    21781 cgcccgggga ccccggtcgt ccccggtcgc cgcagacctt cgagcaggcc ggacaccagg
    21841 ctgagacggg tcctcccggc accgtgccgg tggtgcgcag accgctggac gacatcaccg
    21901 cgaccggcac gctggaggac tacctcgcga agggcacacg cgcgaagcgc ttcaccccgc
    21961 ccgacgacat cggtccggaa acgcgcgccg ccgccgcggt ccacaagtac gcccacgccg
    22021 cccagtgggt ggcgaacttc ggcaccgagg gcttcatcaa cacctggcgg ccctacgtcc
    22081 agtggtcgaa cgagttctcc ctggggcagc tctgggtggt gcggggcagc ggaagcggga
    22141 cggacctgca gaccgtcgaa gtgggcgcgc agacctaccg cgacctgtac ggggactggt
    22201 atccgcacct gttcatcttc tacacgacca acaactacac gcacagcggc gacaacttcg
    22261 gcggctacaa caccgacgtg aacggctggc agcagacatc gcagcgggtc tacccgaccg
    22321 cgcggctggc ggagagcgcg tacggcggcg tccagtacga cctcgcgctg aaggtcaccc
    22381 tctacaacgg caactggtgg gtccgcgtcg gcgacgagtg gatggggtac taccccgccg
    22441 ccctgttcaa ctccacgggg c
//
