LOCUS       NZ_CP071839            22163 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6760568
            Orig. end                         :: 6782731
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..22163
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="24"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..22163
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..22163
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:12163](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..12163
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(613..628)
                     /note="TFBS match to DasR, N-acetylglucosamine dependent
                     repressor, confidence: weak, score: 19.08"
                     /tool="antismash"
     misc_feature    complement(651..669)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: weak, score: 21.38"
                     /tool="antismash"
     gene            790..1746
                     /locus_tag="S1361_RS30375"
                     /old_locus_tag="S1361_30355"
     CDS             790..1746
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675685.1"
                     /locus_tag="S1361_RS30375"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30355"
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_208035082.1"
                     /transl_table=11
                     /translation="MTYTTHISRSIRRNRGAAVVALAAATALLAGCSSKGNADNPLTEN
                     KASGDSVVVGSNNFPESTLLADIYGEALKAKGIKVTYKPNIGSRETTYGLIKNGSISVL
                     PEYNGALLAYLDPKATPKTLGQTTDAVNAKLDSKLTLLNPSAAENKDSVTVNAATAKKY
                     HLTENSTIADLKDVAKDLVIGASPEFQTRQQGLVGLKSVYGLEFKSFKALDAGGPLTLA
                     ALKKDAVQAADIFTTDANISKEKFVVLQDPKNLFGFENVQPLVHKSALSQKGVDTLDAV
                     SAKLDTATLLKLDIQVQMENKDPLDVAKAWLKSAGLA"
     gene            complement(2069..2521)
                     /locus_tag="S1361_RS30380"
                     /old_locus_tag="S1361_30360"
     CDS             complement(2069..2521)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019062785.1"
                     /locus_tag="S1361_RS30380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30360"
                     /product="DUF6114 domain-containing protein"
                     /protein_id="WP_243769355.1"
                     /transl_table=11
                     /translation="MPDRPRRGPRLAFRGWRARRPFWGGLLLALGGGEILLTEKASLKV
                     VLHIGMQGLAGYLLPGLMVLLGLLILFNPAQRLFYSITGILLSLGTWLTSNLGGFFIGL
                     LLGATGSCLTFGWLPDQEPRISRRKRRKQTRTGTRSLTSEGAEGAV"
     gene            complement(2527..3225)
                     /locus_tag="S1361_RS30385"
                     /old_locus_tag="S1361_30365"
     CDS             complement(2527..3225)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996942.1"
                     /locus_tag="S1361_RS30385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30365"
                     /product="DUF6230 family protein"
                     /protein_id="WP_208035084.1"
                     /transl_table=11
                     /translation="MASSPDLPSARNTPEIPGSDAPSETPDTAGTGSGSERRGRVRARR
                     AAVMAVPATLVAAGLAVLTSQGALGVQFAISGMPFTVTATELNGTGFEQFGGLDNMAEG
                     SPNAGDTGGQVLIVTSAIKHATLTRLCQSVDLGGTNLLITAGSGAEKVSATDLTTDSTE
                     LSGDAAFNNIEIGNDASTLTKAGVKGPIGVFSQQADTVRIANLRQTNYATTAGVFKLPG
                     LKLRFGDSGC"
     misc_feature    3400..3413
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: weak, score: 14.6"
                     /tool="antismash"
     misc_feature    complement(3404..3419)
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: weak, score: 20.09"
                     /tool="antismash"
     gene            3868..4518
                     /locus_tag="S1361_RS30390"
                     /old_locus_tag="S1361_30370"
     CDS             3868..4518
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675693.1"
                     /locus_tag="S1361_RS30390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30370"
                     /product="Tat pathway signal sequence domain protein"
                     /protein_id="WP_208035085.1"
                     /transl_table=11
                     /translation="MRTRSLLALAGTATALALTWATPASAADTVLTTGSAGGTAAAVGD
                     TLTAPLASGTSATFYSSPTGTSGVKCTGSQFTAQVTGNPAAPGTATESVTAHTFDNSTC
                     SSNVPGVLGVNGITINNLPYSATITSAGTLTVSPPSGSFIQATVQLRTLLGTVTCVYQA
                     PSLTGKADNADSSITFTNQQFTKSSGSSLCFANGYFTAKYAPVTDAGARVYVN"
     gene            complement(4537..5487)
                     /locus_tag="S1361_RS30395"
                     /old_locus_tag="S1361_30375"
     CDS             complement(4537..5487)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675694.1"
                     /locus_tag="S1361_RS30395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30375"
                     /product="lytic polysaccharide monooxygenase"
                     /protein_id="WP_208035086.1"
                     /transl_table=11
                     /translation="MTRMTARLSVRVAAAAAPLLLLPWAAGPARAHGAPTDPVSRVYAC
                     SPEGGAARTAACRAAIAANGSPFTAWDNLRVAGVAGRDRKVIPDGRLCSGNLPAYRGLD
                     LARRDWPATRLSPGGRLTLTYASTIAHEGTFRLYLTKQGYDPTKPLTWSDLPERPFAQI
                     TDPPLRDGAYRMSATLPADRTGRQVLYTIWQNSSTPDTYYSCSDVVFPERGKAAGAKRP
                     TGAASSAPAQASATGSPTAQASPAQGSPAASSTPGVRGSEGRAERATVHGTPVAQATHG
                     GSGPSAPLLAGGATAVLLLTGGAALVLRLRRPRRR"
     gene            5922..6569
                     /locus_tag="S1361_RS30400"
                     /old_locus_tag="S1361_30380"
     CDS             5922..6569
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675696.1"
                     /locus_tag="S1361_RS30400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30380"
                     /product="ScbR family autoregulator-binding transcription
                     factor"
                     /protein_id="WP_208035087.1"
                     /transl_table=11
                     /translation="MARQLRAEQTRATIITAAADLFDRHGYESTSLSDIVAHAKVTKGA
                     LYFHFAAKEDLAHAILELQAKAAQRLVAEVESRGCSSLEALMRTTFGIARLAVEDPVPR
                     AGLRLAAADIAVRPPLRHPFTEWLEFATRKFSGAVREADVHGDLDVGAVAHSLVCFFIG
                     TRVAGRSLEPAGRLPRRVAEMWHLMIRGLVPVHRRPRYVTLATQLEREIRAA"
     misc_feature    5934..5936
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6592..7791
                     /locus_tag="S1361_RS30405"
                     /old_locus_tag="S1361_30385"
     CDS             6592..7791
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010034217.1"
                     /locus_tag="S1361_RS30405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30385"
                     /product="damage-control phosphatase ARMT1 family protein"
                     /protein_id="WP_208035088.1"
                     /transl_table=11
                     /translation="MPDTPFAPVILGNEPGSFPHSVLAERHPAIIRQVREAFPYGPRQQ
                     AALDELLKSCTQGTIEPLPADAPDRDRWHGWDLAEYAGRSWYDVPWLWSESYFYRRLLD
                     AVGWFGPGAWQGIDPFRPFKRAELDAPETDEELAALDGLRELPEEERARALLHGSLWGN
                     RADLGFRLSAAGAEDREPAPALVADDSGTLWSLLPPGGTGTLVLVADNAGRELVPDLLL
                     IAHLLTEGRAAQAVLHVKPYPYYVSDATTADVVDALHRLRAASGAAAEYGRVLWSAMAD
                     GRLTVRAHPFSCAPLPYAAMPDDLRAEFAAATLTVVKGDLNYRRLVGDRLWPPTTPFRE
                     TTAYFPGPVAALRTLKSDVITGLTAATEAALVAAEGQRWRTGGTHALIQVDPSGELQRQ
                     "
     gene            complement(7768..9033)
                     /locus_tag="S1361_RS30410"
                     /old_locus_tag="S1361_30390"
     CDS             complement(7768..9033)
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015493378.1"
                     /locus_tag="S1361_RS30410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30390"
                     /product="cytochrome P450"
                     /protein_id="WP_208035089.1"
                     /sec_met_domain="p450 (E-value: 3e-15, bitscore: 54.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVPAAPPVPDVFDPRRYASGVPYDAYRVLRDHHPVAWQEEPEVL
                     GWPAGPGFWAVTRHADVVRVLRDAGTYSSYAGATQIRDPDPEDLPFIRRMMLNQDPPGH
                     GRLRRLVSRAFTPGRVDRFAAVARERARTLLAGALEAARQGDGTVDVVAAVTDEYALLN
                     LADLLGVPESDRRLLLHWTQRVIGYQDPDEAGPPVLDGAGRPVNPRSPAMLRDMFAYVR
                     QLAVHKRRHPADDILTTLAHDAELADGELEMFFFLLTVAGNDTVRSAAPGGLLALAGHP
                     EAYELLRAGKVGVPSAVDELLRWHPPVLTFRRTAVRHTGLAGRDIRAGDKVVVFHASAN
                     RDERVFAEPDRLDLARSPNPHVSFGDGPHVCLGAHFARLQLRLLHEEALRVLPGPPRLA
                     GPAGRLVSNFINGIKSLPLQLT"
     gene            complement(9030..9848)
                     /locus_tag="S1361_RS30415"
                     /old_locus_tag="S1361_30395"
     CDS             complement(9030..9848)
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (20-239). E-value:
                     7.2e-26. Score: 83.2. Matches aSDomain:
                     nrpspksdomains_S1361_RS30415_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010983604.1"
                     /locus_tag="S1361_RS30415"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30395"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_208035090.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 6.7e-16, bitscore:
                     58.4, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 2.9e-19, bitscore: 68.5,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSFVLPHEVHGDGAHKVFAVHGWFADRSAYAAVLPDLDRTSFGY
                     ALVDLRGYGEARDATGAYTTAEAAVDLVELADRLGWERFSVIGHSMGGAVAQRLLAVAP
                     HRVRRIAGVSPVPASGMPLAGEQAALFADAAHRAENRRAIIDVTTGGRRPAAWLDRMVA
                     RSLERSDPKAFRAWLDSWAGEDFSADVVGSEVPALAVAGALDPALSPEVMRQTWMSWYP
                     RARLAVLDAAGHYAMDETPLELIRTVEDFLRADAADAPDPATGAREDEPA"
     aSDomain        complement(9132..9788)
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S1361_RS30415_Abhydrolase_1.1"
                     /evalue="7.20E-26"
                     /label="S1361_RS30415_Abhydrolase_1.1"
                     /locus_tag="S1361_RS30415"
                     /protein_end="239"
                     /protein_start="20"
                     /score="83.2"
                     /tool="antismash"
                     /translation="VHGWFADRSAYAAVLPDLDRTSFGYALVDLRGYGEARDATGAYTT
                     AEAAVDLVELADRLGWERFSVIGHSMGGAVAQRLLAVAPHRVRRIAGVSPVPASGMPLA
                     GEQAALFADAAHRAENRRAIIDVTTGGRRPAAWLDRMVARSLERSDPKAFRAWLDSWAG
                     EDFSADVVGSEVPALAVAGALDPALSPEVMRQTWMSWYPRARLAVLDAAGHYAMDE"
     CDS_motif       complement(9558..9593)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_S1361_RS30415_0001"
                     /evalue="4.20E-04"
                     /label="NRPS-te1"
                     /locus_tag="S1361_RS30415"
                     /protein_end="97"
                     /protein_start="85"
                     /score="12.9"
                     /tool="antismash"
                     /translation="VIGHSMGGAVAQ"
     gene            10001..12163
                     /gene="cyc2"
                     /locus_tag="S1361_RS30420"
                     /old_locus_tag="S1361_30400"
     CDS             10001..12163
                     /EC_number="4.1.99.16"
                     /EC_number="4.2.3.22"
                     /EC_number="4.2.3.75"
                     /codon_start=1
                     /gene="cyc2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675700.1"
                     /locus_tag="S1361_RS30420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30400"
                     /product="germacradienol/geosmin synthase Cyc2"
                     /protein_id="WP_208035091.1"
                     /sec_met_domain="T1TS (E-value: 5.1e-80, bitscore: 268.8,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQPFELPRFYMPYPARLNPHLEEARAHSTQWARETGMLEGSGIW
                     EQADLEAHDYGLLCAYTHPDCDGPALSLITDWYVWVFFFDDHFLDMYKRTQDRAAGKAH
                     LDRLPLFMPLDLATPVPEPENPVEAGLKDLWARTVPSMSVDWRRRFSVATEHLLNESMW
                     ELSNINEGRIANPVEYIEMRRKVGGAPWSSGLVEYATAEVPAAVAGTRPLRVLMETFSD
                     AVHLRNDLFSYQREVEDEGENSNGVLVLEKFFGCTTQEAADTVNDVLTSRLHQFEHTAL
                     TEVPAVALEKGLTPGEAAAVAAYTKGLQDWQSGGHEWHLRSSRYMNKGARSDSPWQPKS
                     GPGTSAADIGALLASAAQERLRAYSHVPYQQVGPSRIPDLYMPFQLQLSPHLDHTRGHL
                     VDWCRHMGIVREGVWDEDKLAAYDLALCSAGLDPDATPEALDLSAQWLAWGTYGDDYYP
                     LVYGHRGDLAAARLTTARLSQCMPVEGEPAVVPGNAMERGLIDLWARTTATMTAGQRRT
                     LKASVDAMTESWVWELSNQLQNRVPDPVDYLEMRRATFGSDLTLSLCRMGHGPAVPPAV
                     YRSGPVRSLENSAIDYACLLNDIFSYQKEIEYDGEIHNAVLVVQNFFGVDYPAALAVVH
                     DLTTQRMQQFEHVIAQELPVLYDDFRLSEEARAAMDGYVVDLQNWLAGILNWHRSVDRY
                     KAEWLGRRAHGFLPDRAPAVPALAFG"
     gene            12278..14188
                     /gene="phsA"
                     /locus_tag="S1361_RS30425"
                     /old_locus_tag="S1361_30405"
     CDS             12278..14188
                     /EC_number="1.10.3.4"
                     /GO_function="GO:0005507 - copper ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0050149 - o-aminophenol oxidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="phsA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675701.1"
                     /locus_tag="S1361_RS30425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30405"
                     /product="O-aminophenol oxidase PhsA"
                     /protein_id="WP_208035092.1"
                     /transl_table=11
                     /translation="MTETIERLTGETAGAGAGEKERKGAPETAPEAHELTPYAAPLTVP
                     PVLRPAGDDVLRETEIALRPAWVQLHPQLPPTLMWGYDGHVPGPTIEVRRGQRVRIAWT
                     NRIPKDSEYPVTSVEVPLRTDGRPQATTEPGREGVEPNKDVAALPAWSVTHLHGAQTGG
                     GNDGWADNAVGSGDAQLSEYPNDHQAVQWWYHDHAMNITRWNVMSGLYGTYLVRDDEED
                     ALRLPSGEREIPLLIADRNLDTDEDGRLNGRLLHKTVVVQESNPETGKPVSIPFTGPYT
                     TVNGRIWPYADVDPAWYRFRLVNASNARIFELVLIDEDGEPVTGAVHQIGSDGGLLPRP
                     VPVDFDAELPALTAAPAERFDLLVDFRGLAGRTLRLVNKGPNQPAGVPDPAGNVPYPAV
                     LEFRVGESCEEDTFELPEVLSGSFRRLTHDVPHGHRLILLTPPPTRGAGGHPEIWEMTE
                     VQDTAGLRLPADGIVQITGPDGTTKTYRRTARTFNDGLGFTIGEGSHEQWSFLNLAPIV
                     HPMHIHLADFQLMGRDAYDVSGFDPAAGGTRTPIRYDAGTTIPLAPNERGHKDVFRVPG
                     SQMLRVMGRFDGAYGRFMYHCHLLEHEDMGMMRPFVVMPPEALKFDHGGAHGGHGEGHT
                     G"
     gene            complement(14227..14949)
                     /locus_tag="S1361_RS30430"
                     /old_locus_tag="S1361_30410"
     CDS             complement(14227..14949)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018547157.1"
                     /locus_tag="S1361_RS30430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30410"
                     /product="hypothetical protein"
                     /protein_id="WP_208035093.1"
                     /transl_table=11
                     /translation="MSNTATLALVGDRSPHVASHTRVPLLLDALAARDRLVLDAYWISS
                     QDAEAEGAVRGFDAVWVLPGSPYRSEAGVLAAVRTAREEGIPFLGTCGGFQHTLLEYAR
                     NVCGLTGVAHAENDPDAADPLIEPLACSLLGHEAAVTIDPGSLAASVIGSARTVERYFC
                     AYGPSRHLETLRAHGLRFSGHDQDGQVRMAELPGHPFFLASLFQPELAGDGSDPHPMIR
                     ALARAAVAHAAARAALPV"
     gene            15043..15909
                     /locus_tag="S1361_RS30435"
                     /old_locus_tag="S1361_30415"
     CDS             15043..15909
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1014: LysR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016431962.1"
                     /locus_tag="S1361_RS30435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30415"
                     /product="LysR family transcriptional regulator"
                     /protein_id="WP_208035094.1"
                     /transl_table=11
                     /translation="MDPHLLRTYVTVARLASFSKAARELGYTQSAVSQHIAALEQDLGA
                     PLLTRRPVVPTAAGERLLEHAGPLLLRLDAARADVVRMAAAPQQGLTLVATATALGPAV
                     LGALPPAGVTLRVLTRAEIPAAVATGTADLGLVDGLAAPSDPLRLPDVAPLTTYGIAEE
                     PVSVLLPAGHPLAGRPGLRLGDLRDARWLDAPDAALPLAHLRAATAGGAFRAALRYEGT
                     DVRTLTALTAAGHGLTLLPRSAATALPGATAVPLTAPRLVHRTELLHSGSPGGAAAELV
                     RRLVGGG"
     gene            16247..16801
                     /locus_tag="S1361_RS30440"
                     /old_locus_tag="S1361_30425"
     CDS             16247..16801
                     /GO_function="GO:0005515 - protein binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015657043.1"
                     /locus_tag="S1361_RS30440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30425"
                     /product="PDZ domain-containing protein"
                     /protein_id="WP_208035095.1"
                     /transl_table=11
                     /translation="MEQTALRPKPMPGQDRRDDGTPGAARRPHAAPRRGRRRRTVLFGL
                     CAGVVLVLSGVGIGTVGATVIGMSRLAEPQRKAPPPAQSAEATSTTTSAVAPGPALGVE
                     AVDAEKAGALVVGVHVPGPGYAAGLVRGDVVLQLGAARIDSAADLARAVRRAGPGKALL
                     LTVRHRSGGYQQLTVTPAVVT"
     gene            17184..18311
                     /locus_tag="S1361_RS30445"
                     /old_locus_tag="S1361_30435"
     CDS             17184..18311
                     /EC_number="3.4.-.-"
                     /GO_function="GO:0004177 - aminopeptidase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0070006 - metalloaminopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1172: methionine aminopeptidase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003996926.1"
                     /locus_tag="S1361_RS30445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30435"
                     /product="aminopeptidase P family protein"
                     /protein_id="WP_208035096.1"
                     /transl_table=11
                     /translation="MTGTTPAPFTAADYSARMERAARAAADAGLAGLLVAPGPDMVWLT
                     GYTPTAVTERLTVLVLAPGRDPVLVVPTLEAPDAEHAAGAAALTLRDWTDGKDPYAVTA
                     GLLDDRGRFGISDNTWAMHLLGLQRALPDTSYASLTDALPMLRAVKDAAELELLAAAGA
                     AADATFEEIRKVPFAGRRESDVGHDLAGLLRRFGHSQVDFTIVGSGPNGANPHHEVGDR
                     VIQPGDMVVLDFGGLKDGYGSDTTRTVHVGEPTEEERRVHDVVRAAQEAGFRAVGPGVA
                     CQEVDRAARAVIADAGYGEYFIHRTGHGIGVTTHEPPYMIEGEEQPLVPGMCFSVEPGI
                     YLPGRFGVRIEDIVTVTEDGGRRLNNTTREMVIVD"
     gene            18365..19300
                     /locus_tag="S1361_RS30450"
                     /old_locus_tag="S1361_30440"
     CDS             18365..19300
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) APH"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675704.1"
                     /locus_tag="S1361_RS30450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30440"
                     /product="phosphotransferase"
                     /protein_id="WP_208035097.1"
                     /sec_met_domain="APH (E-value: 3.8e-16, bitscore: 58.5,
                     seeds: 156, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTQAPTPTADTVRRLVRSLLKEGGDDAGGPDVRPVTEDREHTWWI
                     GSRHVLRLAPDREASVRRRRELRLRDLIRPHVPVAVPTSVAHGDWAPGLAYTLDTRVPG
                     GTADEYDVSAVGEADLAGLLSGLRAVPARQAEALGVPRTAPRSLEALRRMAVHAAERLA
                     AADEFDAARLHQLTPPGAAQLAAQPGTAVLTHHGLTGAHVVVSADGRVRGILDWTAAAL
                     GDPAEDIAGLAVAVGSPPAVRAATLAGYGARPCLRGLWLARCDTVIRLTGHLEGRTGGS
                     LPLLRTQLRRAWEPILLERVTDFQEDAPEP"
     gene            complement(19388..21133)
                     /gene="treZ"
                     /locus_tag="S1361_RS30455"
                     /old_locus_tag="S1361_30445"
     CDS             complement(19388..21133)
                     /EC_number="3.2.1.141"
                     /GO_function="GO:0033942 -
                     4-alpha-D-(1->4)-alpha-D-glucanotrehalose trehalohydrolase
                     activity [Evidence IEA]"
                     /GO_process="GO:0005992 - trehalose biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="treZ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1297: Pullulanase, type I"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014675705.1"
                     /locus_tag="S1361_RS30455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30445"
                     /product="malto-oligosyltrehalose trehalohydrolase"
                     /protein_id="WP_208035098.1"
                     /sec_met_domain="Alpha-amylase (E-value: 8.3e-11, bitscore:
                     40.8, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQFEVWAPQADRVTLHCEGTTRALARDPAREGWWTGETEAQDGAR
                     YGFSLDDGPVLPDPRSRRQPDGPDGLSAVVDHGRHEWRTQWPGRGLPGAVLYELHVGTY
                     TREGTLDAAAARLEHLVELGVTHVELMPLCPFPGRHGWGYEGVSLWAVHEPYGGPEALK
                     RFVDRAHGLGLGVVLDVVHNHLGPSGNYLPRFGPYFTDTHTTPWGSAVNLDAPGSDEVR
                     AFLLGSALAWLRDYRIDGLRLDAVHSLYDTRACHFLEELSAAVDGLADEVGRPLFLIAE
                     SDLNNPRFITPRAEHGLGLHAQWNDDFHHALHTALTGESQGYYADFARDPFGALAKTLT
                     GGYFHDGTYSSFRGRSHGRPLDRARVAGHRLLGYSQTHDQVGNRAQGDRLSALVSPGLL
                     ACAATLTLTAPFTPMLFMGEEWAAGTPWQFFTDHTDAELAEAVRRGRRREFASHGWAEE
                     DVPDPQDPATRERSCLDWSEPEREPHARVLAWYRRLVALRREQPDLTDPDLADTKVAYD
                     ADARWLAFRRGDVRVAVNLGRQEAAIPLGTGRVDVLAAWDPVEAPGPDGLLQVPGESCV
                     VLTQP"
     misc_feature    21178..21198
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 18.81"
                     /tool="antismash"
     gene            21310..21861
                     /locus_tag="S1361_RS30460"
                     /old_locus_tag="S1361_30450"
     CDS             21310..21861
                     /GO_function="GO:0051219 - phosphoprotein binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004923468.1"
                     /locus_tag="S1361_RS30460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_30450"
                     /product="DUF1707 and FHA domain-containing protein"
                     /protein_id="WP_208035099.1"
                     /transl_table=11
                     /translation="MTSSFEFSTYPARLSDEERDKALRVLRDGVAMGRLSHDTFVRRME
                     LALVARRSDELAALVADLPRENRFSRAVLGTVEAVSGFTVRLRRAWQAERLPKLLLPQP
                     SHTHPLRIGRDPANGLRLNHETVSRVHAELRHQGGLWILRDLGSTNGTTVNGRRVIAAV
                     VVREGDQVAFGRAAFRLAAR"
     misc_feature    21948..21964
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 20.06"
                     /tool="antismash"
ORIGIN
        1 gccgggtcga tgttgtcggc cggcaggtac gactgctcca ccgaggtgcg caggctgctc
       61 agaccctcga cgccgcgcag ggcctgcgcc tcgctccgcg gcagccggtc gccgaaggcc
      121 tcgcgcaccc tggtcgcctg ggtatccacc gcgtgctggg ccgcccggta ggcgtccgtc
      181 gacgggtgcg cgtccccgga ctcgtagcgc gtcgagagca ggatggcctg ctggtgctcg
      241 gcctccaccc ggtccaccag ccgcgccacc tgcgcactgt cccgcaccag ccgggccgcg
      301 gcggccgcgc tggacgactg ctgcaccagg tcggtgatga ggtacgcgag caggccggcg
      361 atgaccgcga gggggatgcc gacgagcagg ttgagcttgc gccggaaggg ccagcggtcg
      421 gcgaatgccc gtgccgctcc ccggacgggg gcgtgtcggt cgggcgcgtc cacctcgttc
      481 gtggacaccg ggcctccttc gtgggtgtct tgtccgggag agacagtcgc tcccggatct
      541 cccggacgcc gagggcctcg tcgccctcgg aacgcctgtg ctcacgacac cgaagcgggc
      601 cccgcacacc gctgtggtcg ataccaactg ggccgagact acagtccgct tgaggtgacc
      661 atcagctcac ctttcatcaa gaatccgtta cgaagagggt gctgtccgtg gtcaagcggt
      721 cgcggatcga ggccaatcgg tgatctgtgg gccttgactg accaggaacc ggctggattg
      781 gatcggcgcg tgacttacac gacccacatc agcaggtcca tccggaggaa ccgaggcgcg
      841 gcggtggtcg ccctggcggc ggcgacggct ctgctggcgg gctgttcctc caagggcaac
      901 gccgacaacc ccctcacgga gaacaaggcg agcggcgaca gcgtcgtcgt cggatccaac
      961 aacttccccg agagcacgct gctcgccgac atctacggcg aggctctcaa ggccaagggg
     1021 atcaaggtca cctacaagcc gaacatcggc agccgcgaga ccacctacgg actgatcaag
     1081 aacggttcca tctcggtcct gcccgagtac aacggcgcac tgctggccta cctcgacccg
     1141 aaggccaccc cgaagaccct cggtcagacc acggacgccg tcaacgccaa gctggactcc
     1201 aagctcacac tgctcaaccc gtcggcggcg gagaacaagg actcggtcac ggtcaacgcg
     1261 gccaccgcga agaagtacca cctcaccgag aactcgacca tcgccgacct gaaggacgtc
     1321 gccaaggatc tggtcatcgg cgcctcgccg gagttccaga cccggcagca gggcctggtg
     1381 ggcctgaagt ccgtctacgg actggagttc aagtccttca aggcgctgga cgcgggtggt
     1441 ccgctgacgc tggcggcgct gaagaaggac gccgtccagg ccgcggacat cttcaccacc
     1501 gacgcgaaca tctccaagga gaagttcgtc gtcctgcagg acccgaagaa cctcttcggg
     1561 ttcgagaacg tgcagccgct cgtccacaag agcgcgctgt cccagaaggg cgtcgacacc
     1621 ctcgacgcgg tctccgccaa gctcgacacc gcgaccctgc tgaagctgga catccaggtg
     1681 cagatggaga acaaggaccc gctggacgtg gccaaggcct ggctgaagtc cgccggtctc
     1741 gcctgacgcc caccactcga acgacccgct ggaacgaccg gtacgaccgc gggcctaaca
     1801 ggcgcgggtg cccccggact cgggggcacc cgccccgcgt cccgctcgac ggccgggcct
     1861 cgccctgccc gccccggtcc ggctcgccga cgccggggcc gccgcccggc tggccaccgt
     1921 cggcgagaac accctggccc acgccccctc ctggcctctt ggaccgctct cccgcccacc
     1981 ccctctccgc tcagtcctcc tctccctcga agaagtcccc gatctcgtcc acgacttccg
     2041 acccccgtcc atacccaggc agcccccctc agaccgcccc ctccgccccc tccgaagtca
     2101 gggagcgggt gccggtgcgt gtctgcttgc ggcgcttgcg gcggctgatg cgcggctcct
     2161 ggtcggggag ccagccgaag gtgaggcagc tgccggtggc gccgaggagc agaccgatga
     2221 agaagccgcc cagattggag gtgagccagg tgcccaggga gagcagaatg ccggtgatgg
     2281 agtagaagag ccgctgggcg gggttgaaga ggatcagcag gcccagcagc accatgaggc
     2341 ccggcagcag atagccggcc aggccctgca tgccgatgtg cagcacgacc ttcagcgagg
     2401 ccttctcggt gagcaggatc tcgccgccgc cgagggcgag cagcaacccg ccccagaacg
     2461 gccggcgggc ccgccatccg cggaaggcga gcctcggtcc ccggcgtgga cggtccggca
     2521 cggtgatcag caacccgagt cgccgaagcg gagcttgaga cccggcagct tgaacacacc
     2581 ggccgtggtc gcgtagttgg tctgccgcag gttggcgatc cgcacggtgt cggcctgctg
     2641 actgaagacg ccgatcggac ccttcacgcc cgccttggtc agcgtgctgg cgtcgttgcc
     2701 gatctcgatg ttgttgaacg ccgcgtcgcc cgacagttcg gtggagtcgg tggtcaggtc
     2761 ggtcgcgctg accttctccg ccccgctgcc cgcggtgatc agcaggttcg tgccgccgag
     2821 gtcgacgctc tggcacagcc tggtgagcgt ggcgtgcttg atcgcggagg tgacgatgag
     2881 cacctggccg ccggtgtccc cggcgttcgg gctgccctcc gccatgttgt cgagtccgcc
     2941 gaactgctcg aacccggtgc cgttcagttc tgtggcggtg accgtgaacg gcattccgga
     3001 gatggcgaac tgcacaccca gcgcgccctg cgaggtgagg accgcgaggc cggcggcgac
     3061 cagggtggcg ggtaccgcca tcaccgcggc ccggcgggcc cggacgcgtc cccgtctctc
     3121 gctgccggag ccggtgcctg cggtgtcggg ggtttcggag ggggcgtcgc ttccagggat
     3181 ctcgggggtg ttgcgggcgg acgggaggtc cggggacgag gccatgtctg ctcccatgca
     3241 tggatcaatg cgggttgggc ttcagcggcg cggtgtcctg gcgcggacag cggatgccgc
     3301 gtacgcctcc tcgcaactcc cggcgggtgc aagggctttc tcgttacgcg gcggtagcct
     3361 tcgaggaagt taccgccggt tactttaagg ggtcaaggga gttgtgaaaa aagggtgtcg
     3421 gatgtgcgcg ggcccgtacc cgcctgctac aactcccctt ccggaccttg acgttggcgg
     3481 ttgaccaggt ctacaacttc ccctgtttcc acggatccgt ggcgccggat ccagcaggcg
     3541 gcacccgccg cgtccccggc gtggccctcg ccgcgccccc gcggtaccgg ccgcgttccc
     3601 ggcccggtca cggcaagcgc tccacctcac acagcggcac cggcacgtcg ttccctcttt
     3661 ctcaccgtgc ccggccgctc ccttgtccgg cccggccgga ggccttcccc cgaggccttc
     3721 ggccggtgtc cggtgtgccg ccgtcgcggg accgccgcgt acggagaagg cgccacggcc
     3781 ccgcgccggc ggcatccccc gcaccacccg ccacccgcca cccgccacct catctgtccc
     3841 cccccacatc ggaagagagg cacccgcatg cgtacgcgct ccctcctcgc cctcgccggc
     3901 accgccacgg cgctcgccct cacctgggcc accccggcct ccgccgccga cacggtcctg
     3961 accaccggca gtgccggcgg caccgcggcc gccgtcggcg acaccctgac cgcgcccctg
     4021 gcctccggta cctccgccac cttctactcc agcccgaccg gcaccagtgg cgtgaagtgc
     4081 acgggatccc agttcacggc ccaggtcacc ggcaacccgg ccgcgcccgg tacggccacc
     4141 gagtccgtca ccgcgcacac cttcgacaac agcacctgtt ccagcaacgt ccccggtgtc
     4201 ctcggtgtca acgggatcac catcaacaac ctgccgtact ccgcgacgat cacctcggcc
     4261 ggcaccctca ccgtctcgcc gccgagcggc tccttcatcc aggccaccgt ccagctgcgc
     4321 actctgctgg gcaccgtcac ctgcgtctac caggcgccca gcctgaccgg caaggccgac
     4381 aacgccgaca gcagcatcac cttcacgaac cagcagttca ccaagagctc cggctcgtcg
     4441 ctgtgcttcg ccaacggcta cttcacggcc aagtacgcgc ccgtcaccga cgccggtgcc
     4501 cgggtctacg tcaactgacc gaccggaggg tccggttcag cgtcgtcgcg gacgccgtag
     4561 ccggagaacc agggcggcgc caccggtgag cagcagcacc gcggtggcgc cgcccgccag
     4621 cagcggcgcc gagggtcccg aaccgccgtg cgtggcctga gcaacagggg tcccgtggac
     4681 ggtggcacgc tcggcccgcc cctcgctccc gcgcacaccg ggagtcgaac tcgccgccgg
     4741 ggaaccctgc gcaggcgacg cctgtgcggt cggcgaaccc gttgccgatg cctgtgcggg
     4801 tgccgaagac gccgctcccg tgggccgctt ggccccggcg gctttcccgc gctccgggaa
     4861 caccacgtcg gaacacgagt agtacgtgtc cggcgtactg ctgttctgcc agatcgtgta
     4921 gagcacctgg cgtcccgtcc ggtcggccgg cagcgtggcg ctcatccggt acgccccgtc
     4981 gcgcagcggc gggtccgtga tctgggcgaa gggccgctcc ggcaggtccg accaggtcag
     5041 cggtttcgtg gggtcgtacc cctgcttggt caggtacagc ctgaacgtgc cctcgtgcgc
     5101 gatcgtcgac gcataggtca gcgtcagccg gccacccgga ctcagccgcg tcgccggcca
     5161 gtcccgccgc gccaggtcca ggccgcggta cgccggcagg ttcccgctgc acagtctgcc
     5221 gtccgggatc accttccggt cgcgacctgc cacccccgcc acccgcaggt tgtcccacgc
     5281 ggtgaacgga gagccgttcg ccgcgatcgc ggcccggcag gccgccgtcc gggcggcgcc
     5341 gccctcgggc gagcaggcgt agacccggct gaccgggtcc gtcggggctc cgtgcgcccg
     5401 ggcgggcccc gccgcccacg gcagcagcag caacggtgcc gccgcagcgg ccaccctgac
     5461 gctcaggcgg gcggtcatcc gagtcatccg ggacgtctcc tcggcgggcg cgggaacagg
     5521 gtctgcggcg tccagtacgg cgcgggcgtc cgacgcgttc agtccgatcg gcgcgcccgt
     5581 gcgcgggggg cgtgaaagca ccgaccggtt cggctgtttt gcgcctgctt ccacgtgccg
     5641 ttgaggagcc ggccgtccgc ctcgtatcgt ggcgatcatg ggcgcggcag tcgtcgtgcc
     5701 ccggctgccg ggcgcccgcc cgtgacgaag ggggaatccg atgtgggctc gcccgtttcg
     5761 cctggcgccg agcgtgcagc cggtgccggg cgggccggtg acacgtgtcg cagtgcgcgt
     5821 gacacaccgg actcccgtcg ccgttgggtg agttatcgta tccaaggggt taaaaacaaa
     5881 ccgcatgtcc tgttcgttag aggtgcgagg aggggtcgag gatggcgagg cagttacgcg
     5941 ctgaacagac ccgggcaacg atcatcacgg ccgccgccga tctgttcgac cggcacgggt
     6001 acgaatccac cagcctgagc gacatcgtcg cacacgcgaa ggtcaccaag ggcgccctgt
     6061 acttccactt cgccgccaag gaggatctgg cccacgccat cctggagctc caggccaagg
     6121 ccgcgcaacg gctcgtcgcc gaggtcgaga gccgtggctg ctcctcgctg gaggccctga
     6181 tgcgcaccac gttcgggatc gcccggctcg ccgtggagga ccccgtgccg cgcgccggac
     6241 tgcgtctcgc cgccgcggac atcgccgtac gaccgccgct gcggcatccg ttcaccgagt
     6301 ggctggagtt cgccacccgg aagttcagcg gggccgtcag agaggccgac gtgcacggcg
     6361 acctcgacgt cggcgccgtc gcccactccc tcgtctgctt cttcatcggc acccgcgtcg
     6421 ccggccgctc gctggaaccg gccgggcggc tgccgcgcag agtcgccgag atgtggcacc
     6481 tcatgatccg cggactcgtc ccggtgcacc gccgcccccg ctacgtcacc ctcgccacgc
     6541 agctggagcg ggagatccgc gccgcctgac gcccgcgata ccgtgacgga catgcccgac
     6601 acccccttcg cacctgtgat cctcggcaac gaacccggct ccttcccgca cagcgtgctg
     6661 gccgagcggc acccggcgat catccggcag gtacgggagg cctttccgta cggcccccga
     6721 cagcaggcgg ctctcgacga gctgctgaag agctgcaccc aggggacgat cgagccgctc
     6781 ccggccgacg ccccggaccg tgaccggtgg cacggctggg acctggccga gtacgccggc
     6841 cggtcctggt acgacgtgcc gtggctgtgg tccgagagct acttctaccg ccggctgctg
     6901 gacgccgtcg gctggttcgg cccgggcgcc tggcagggca tcgacccctt ccgccccttc
     6961 aaacgcgccg aactcgacgc cccggagacc gacgaggaac tcgccgccct ggacggcctg
     7021 cgcgagctgc cggaggagga gcgggcccgc gcactgctgc acggctcgct gtggggcaac
     7081 cgcgccgacc tcggcttccg gctctccgcc gcgggcgccg aggaccggga accggccccc
     7141 gcgctcgtcg cggacgacag cgggaccctc tggtcgctgc tgccgcccgg tgggacgggc
     7201 acgctcgtgc tcgtcgcgga caacgcgggc cgcgaactcg tccccgatct cctgctgatc
     7261 gcccacctcc tcaccgaagg ccgcgccgca caggccgtcc tgcacgtcaa gccgtacccg
     7321 tattacgtct ccgacgccac caccgccgac gtggtcgacg ccctgcaccg gctgcgcgcg
     7381 gcctccggcg cggccgccga gtacgggcgg gtgctctggt cggcgatggc cgacggccgg
     7441 ctcaccgtcc gcgcccatcc cttctcctgc gcaccgctgc cctacgccgc gatgcccgac
     7501 gacctgcgcg ccgagttcgc ggcggccacg ctgaccgtcg tcaagggcga cctgaactac
     7561 cgccgcctgg tgggcgaccg gctctggccg cccaccacgc ccttccgtga gaccaccgcg
     7621 tacttccccg gcccggtcgc cgcgctgcgc accctgaagt ccgatgtgat caccggactc
     7681 acggccgcga ccgaggccgc actggtggcg gccgaggggc agcgctggcg gaccggcggc
     7741 acacacgcgc tgatccaggt cgatccgtca ggtgagctgc agcggcagtg acttgatgcc
     7801 gttgatgaag ttcgacacca gccgcccggc cggtccggcg agccgcggcg gcccgggcag
     7861 gacccgcagc gcctcctcgt ggagcagccg cagttgcaac cgggcgaagt gggcgccgag
     7921 gcacacgtgc gggccgtccc cgaaggagac gtgcggattg ggggagcggg cgaggtcgag
     7981 ccggtcgggc tcggcgaaga cgcgctcgtc ccggttggcc gaggcgtgga acacgacgac
     8041 cttgtcgccc gcccggatgt cgcggcccgc cagtccggtg tgccgtacgg ccgtccgccg
     8101 gaaggtcagc accggcgggt gccagcgcag cagctcgtcc acggcggagg gcacgccgac
     8161 cttccctgca cgcagcagct cgtacgcctc cgggtgcccg gccagggcca gcagcccgcc
     8221 cggggccgcg ctgcgcacgg tgtcgttgcc ggccacggtg agcaggaaga agaacatctc
     8281 cagctcaccg tcggcgagtt cggcatcgtg cgcgagtgtc gtcaggatgt cgtcggcggg
     8341 gtgccgtctc ttgtgtacgg ccaactggcg cacgtaggcg aacatgtccc gcaacatcgc
     8401 cggtgaccgc gggttcaccg gcctgcccgc gccgtccagc accggcggac cggcctcgtc
     8461 cggatcctgg tagccgatga cccgctgcgt ccagtgcagc agcagccgcc ggtcgctctc
     8521 cgggacgccc agcagatccg ccaggttcag cagggcgtac tcgtcggtga cggcggccac
     8581 cacatcgacc gtgccgtcgc cctgccgcgc cgcctccagg gcgcccgcca gcagcgtccg
     8641 tgcccgctcc cgggcgaccg ccgcgaaccg gtccacacgc cccggcgtga aggcacggct
     8701 caccagccgc cgcagccgcc cgtgccccgg cggatcctgg ttgagcatca tccgccggat
     8761 gaacggcagg tcctccgggt ccgggtcccg gatctgggtc gcaccggcgt acgaggagta
     8821 cgtccccgcg tccctcagca cacggaccac gtccgcgtgc cgggtcacag cccagaaccc
     8881 gggcccggcc ggccagccca gcacctccgg ctcctcctgc caggccaccg gatggtggtc
     8941 gcgcagcacc cggtaggcgt cgtagggaac cccgctggcg tagcggcgcg gatcgaagac
     9001 gtccgggacc ggcggcgccg cgggcacgct cacgccggct cgtcctcgcg cgccccggtt
     9061 gccgggtcgg gcgcgtccgc cgcgtccgcc cgcaggaagt cctcgacggt acggatcagt
     9121 tccagcgggg tctcgtccat ggcgtagtgg cctgcggcgt ccagcacggc gagccgcgcg
     9181 cgcgggtacc agctcatcca ggtctgccgc atgacctccg gcgacagcgc cggatcgagc
     9241 gcgccggcca cggcgagcgc cggcacctcg ctgcccacga cgtcggcgct gaagtcctcg
     9301 cccgcccacg agtccagcca ggcccggaag gccttggggt cgctgcgctc cagcgagcgg
     9361 gcgaccatcc ggtccagcca ggcggcgggc cgccggcccc cggtggtgac gtcgatgatc
     9421 gcgcgccggt tctccgcccg gtgcgccgcg tccgcgaaca gcgccgcctg ctccccggcc
     9481 agcggcatgc ccgaggcggg caccggcgag accccggcga tccggcgcac ccggtgcggg
     9541 gccacggcga gcagccgctg cgccaccgca ccgcccatgg agtgcccgat caccgagaac
     9601 cgctcccagc cgagccggtc cgccagctcc accaggtcca cggccgcctc ggccgtcgtg
     9661 tacgcgcccg tggcgtcccg ggcctcgccg tagccgcgca ggtcgaccag cgcgtaaccg
     9721 aaggacgtgc ggtcgaggtc cggcaggacg gccgcgtagg cggaccggtc ggcgaaccag
     9781 ccgtgcacgg cgaacacctt gtgggcgccg tcgccgtgca cctcatgggg caacacgaag
     9841 gaggtcatgc gcctaccgtg gcgcccgcgc gcgggcacgg caagggcacc aacgccacaa
     9901 ccccccgccc gagttccccc tttcacgggc ggttcacgcg atggtgtgat catgtacccc
     9961 ggggtggatg ggggtccggg gccccgggta gtgcccggcc atgacgcagc cgttcgaact
    10021 cccgcgcttc tacatgccgt atcccgcgcg gctcaacccg cacctggagg aggcccgggc
    10081 ccactcgacg cagtgggccc gggagacggg catgctggag ggctccggaa tctgggaaca
    10141 ggccgacctg gaggcgcacg actacggcct cctgtgcgcc tacacccacc ccgactgcga
    10201 cggacccgcc ctctcgctga tcaccgactg gtacgtgtgg gtgttcttct tcgacgacca
    10261 cttcctcgac atgtacaagc gcacccagga ccgcgccgcc ggaaaggcgc acctggaccg
    10321 cctgccgctg ttcatgccgc tcgacctcgc cacccccgtg ccggaaccgg agaatccggt
    10381 ggaggccggg ctgaaggacc tgtgggcgcg gacggtgccg tcgatgtccg tggactggcg
    10441 ccgccgcttc tccgtcgcca ccgagcatct gctcaacgag tcgatgtggg agctgtccaa
    10501 catcaacgag gggcggatcg ccaacccggt cgagtacatc gagatgcgcc gcaaggtcgg
    10561 cggcgccccc tggtcctccg ggctcgtgga gtacgcgacc gccgaggtgc ccgccgcggt
    10621 cgccggcacc cggccgctgc gcgtcctcat ggagacgttc tccgacgccg tccacctgcg
    10681 caacgacctg ttctcctatc agcgcgaggt cgaggacgag ggggagaaca gcaacggcgt
    10741 gctcgtcctg gagaagttct tcggctgcac cacacaggag gccgccgaca ccgtcaacga
    10801 cgtgctcacc tcccggctgc accagttcga gcacaccgcg ctgacggaag tcccggccgt
    10861 cgccctggag aagggcctca cgcccggcga ggccgccgcc gtcgccgcct acaccaaggg
    10921 actccaggac tggcagtccg gcggccacga atggcacctg cgctccagcc gctacatgaa
    10981 caagggcgca cggtccgact cgccctggca gccgaagagc ggtcccggaa cctccgccgc
    11041 cgacatcggc gcactcctcg cctcggccgc ccaggaacgc ctgcgcgcct actcccacgt
    11101 gccgtaccag caggtcggcc cgtcccgcat ccccgacctg tacatgccct tccagctcca
    11161 gctcagcccc cacctcgacc acacccgcgg ccacctcgtc gactggtgcc gtcacatggg
    11221 catcgtccgg gagggcgtct gggacgagga caagctcgcc gcgtacgacc tcgcgctgtg
    11281 ctccgccggc ctggacccgg acgccacgcc ggaggccctc gacctgagcg cgcagtggct
    11341 cgcctgggga acctacggcg acgactacta cccgctcgtg tacggccacc gcggggacct
    11401 ggccgccgcc cggctgacca cggcccggct gtcgcagtgc atgccggtcg agggcgaacc
    11461 ggccgtcgtc cccggcaacg ccatggaacg cggtctgatc gacctctggg cgcgcaccac
    11521 ggccacgatg accgccggcc agcgccgcac cctgaaggca tccgtggacg cgatgaccga
    11581 gagctgggtg tgggagctgt ccaaccagct ccagaaccgc gtccccgacc cggtcgacta
    11641 cctggagatg cgccgcgcca ccttcggctc cgacctcacc ctgagcctgt gccgcatggg
    11701 ccacggaccc gcggtcccgc cggcggtgta ccgcagcggc ccggtgcgct cgctggagaa
    11761 ctccgccatc gactacgcgt gcctcctgaa cgacatcttc tcgtaccaga aggagatcga
    11821 gtacgacggc gagatccaca acgccgtcct ggtcgtgcag aacttcttcg gcgtggacta
    11881 cccggccgcg ctcgccgtcg tgcacgatct gacgacccag cgcatgcagc agttcgagca
    11941 cgtgatcgcg caggaactcc cggtcctgta cgacgacttc cgactgtccg aggaggcgcg
    12001 ggccgccatg gacggctatg tggtcgacct gcagaactgg ctggccggca tcctgaactg
    12061 gcaccggagc gtcgaccgtt acaaggccga gtggctcggc cgccgcgccc acggcttcct
    12121 gcccgaccgg gctcccgccg tgcccgccct ggcgttcggc tgacgatcgc cgaatcttct
    12181 cgtgcggaat cgggcattca gggaacttcg gtgagccctc gggagtcttg tggagtaagg
    12241 ggaacaacaa accacgaaca cgcgggggtg ttcgaccttg accgagacca tcgagaggct
    12301 caccggagag accgccggag ccggcgcggg ggagaaggag aggaaggggg cgcccgagac
    12361 ggcgcccgag gcgcacgaac tgacgccgta cgccgcaccg ctgaccgtgc cgccggtcct
    12421 gcggcccgcc ggcgacgacg tgctgcgcga gacggagatc gccctgcgcc cggcctgggt
    12481 gcaactgcac ccgcagctgc cgccgaccct gatgtggggc tacgacggac acgtgccggg
    12541 cccgaccatc gaggtgcggc gcggacagcg cgtccgcatc gcctggacca accgcattcc
    12601 caaggacagc gagtacccgg tcacctccgt cgaggtgcca ctgcgcaccg acggccgtcc
    12661 gcaggccacc accgagcccg gccgcgaggg cgtcgaaccg aacaaggacg tcgccgccct
    12721 gcccgcctgg tcggtgaccc acctgcacgg cgcacagacc ggcggcggca acgacggctg
    12781 ggcggacaac gccgtgggct ccggcgacgc ccagctgtcg gagtacccga acgaccacca
    12841 ggcggtgcag tggtggtacc acgaccacgc gatgaacatc acccggtgga acgtgatgtc
    12901 gggcctgtac ggcacctacc tcgtccggga cgacgaggag gacgccctcc gcctgccctc
    12961 cggcgagcgg gagatcccgc tcctcatcgc cgaccgcaac ctcgacaccg acgaggacgg
    13021 ccgcctcaac ggccggctcc tgcacaagac ggtggtcgtc caggagagca acccggagac
    13081 gggcaagccg gtctccatcc cgttcaccgg cccgtacacc acggtcaacg gccgtatctg
    13141 gccgtatgcc gacgtcgacc cggcctggta ccggttccgg ctggtcaacg cctccaacgc
    13201 gcgcatcttc gagctcgtcc tgatcgacga ggacggcgag ccggtcacgg gggccgtcca
    13261 ccagatcggc agcgacggcg gcctgctgcc gcgcccggtg ccggtcgact tcgacgcgga
    13321 gctgcccgcc ctgaccgccg cgccggccga gcgcttcgac ctgctggtgg acttccgcgg
    13381 gctggccgga cggaccctcc gcctggtgaa caaggggccc aaccagccgg cgggcgtgcc
    13441 cgatccggcg ggtaacgtgc cctacccggc cgtgctggag ttccgggtcg gggagagctg
    13501 cgaggaggac accttcgaac tgcccgaggt gctctccggc tccttccgcc gcctcaccca
    13561 cgacgtcccg cacggccacc gcctgatcct gctcaccccg ccccccacca ggggcgccgg
    13621 cgggcacccg gagatctggg agatgaccga ggtccaggac accgccgggc tccggctccc
    13681 ggccgacggc atcgtccaga tcaccggacc cgacggcacc acgaagacgt accggcgcac
    13741 cgcacggacg ttcaacgacg ggctcggctt caccatcggc gagggcagcc acgagcagtg
    13801 gagcttcctc aacctcgcgc ccatcgtgca ccccatgcac atccacctgg ccgacttcca
    13861 gctgatgggc cgggacgcct acgacgtctc cggcttcgac ccggcggccg gcggcacgcg
    13921 aaccccgatc cggtacgacg cggggacgac gatcccgctc gcacccaacg agcgcggcca
    13981 caaggacgtc ttccgggtcc cgggcagcca gatgctgcgg gtcatgggcc gcttcgacgg
    14041 ggcgtacggc cggttcatgt accactgcca cctgctggag cacgaggaca tgggcatgat
    14101 gcggcccttc gtcgtcatgc cgcccgaggc cctcaagttc gaccacggcg gggcccacgg
    14161 cggccacggc gaggggcaca cgggctgagg acgggcggag tcacatgggc tgaggacggg
    14221 cgggggtcac accggcaggg cggcccgggc cgccgcgtgc gcgaccgcgg ctcgcgccag
    14281 tgcccggatc atcgggtgcg ggtccgagcc gtcaccggcc agctcgggct ggaacagcga
    14341 ggccaggaag aacggatggc cgggcagctc ggccatccgg acctggccgt cctggtcgtg
    14401 gccggagaac cgcagtccgt gggcgcggag cgtctccagg tggcgggagg ggccgtaggc
    14461 gcagaagtac cgctccaccg tgcgcgccga gccgatcacg gacgcggcca gcgagccggg
    14521 gtcgatcgtc accgctgcct cgtgacccag cagcgagcag gccagcggct cgatgagcgg
    14581 gtccgcggcg tccgggtcgt tctcggcgtg cgcgacgccg gtcagaccgc acacgttccg
    14641 ggcgtactcc agcagcgtgt gctggaagcc gccgcacgtg cccaggaacg ggatgccctc
    14701 ctcgcgcgcg gtgcgcaccg ccgcgaggac acccgcctcg ctgcggtagg gactgcccgg
    14761 cagtacccac acggcgtcga agccgcgcac cgcgccctcg gcctcggcgt cctgcgagga
    14821 gatccagtac gcgtccagga ccaaccggtc gcgggcggcc agcgcgtcca gcaggagcgg
    14881 gacgcgggtg tgcgaggcga cgtgcgggga gcggtccccg acgagggcga gggtggcggt
    14941 gttcgacatg gccaccatcc tccggacgac gggtggttca cgtccaacga tggttggtgc
    15001 acggtcgata agcgttactg atgcagtggg atgctgtgcc gtatggaccc gcatctgctg
    15061 cgcacgtacg tcaccgtggc gcgtctcgcc tccttctcga aggccgcgcg cgagctgggc
    15121 tacacccagt ccgccgtctc ccagcacatc gccgccctcg aacaggacct gggcgcccca
    15181 ctgctgaccc gccggccggt cgtgcccacc gcggcgggcg agcggctgct ggagcacgcg
    15241 ggcccgctgc tgctgcggct cgacgcggcc cgcgccgacg tcgtccgcat ggccgccgcg
    15301 cctcagcagg gtctgaccct cgtcgccacc gcgaccgccc tgggccccgc cgtcctcggc
    15361 gcgctcccgc cggccggcgt caccctgcgc gtcctcaccc gcgcggagat ccccgccgcc
    15421 gtcgccaccg gcaccgcgga cctgggcctc gtcgacgggc tggccgcgcc gagcgatccg
    15481 ctgcggctgc ccgacgtggc accgctgacc acgtacggca tcgccgagga acccgtgagc
    15541 gtcctgctgc ccgccggaca ccccctcgca ggtcgccctg gcctgcgcct cggcgacctg
    15601 cgtgacgccc gctggctcga cgcgcccgac gcggcactcc cgctcgcgca cctgcgcgcc
    15661 gctaccgccg gcggcgcctt ccgggccgcc ctgcgctacg agggcaccga cgtccgcacc
    15721 ctcaccgccc tcacggccgc cggacacggc ctcaccctgc tgccccgttc ggcggccacg
    15781 gccctccccg gcgcgaccgc cgtccccctc accgcccccc gcctcgtcca ccgcacggaa
    15841 ctcctccaca gcggcagccc cggaggagcg gcggcggaac tggtgcggcg cctggtgggc
    15901 ggcgggtgac aggggaggcg ctacggcacg ccgaacccgc gcgggaacag ggccccaccg
    15961 ggccagaggc tccaccggac caggggcgtg caccggtcgg gctcgctggg tgaacttccc
    16021 ccggcgggct gtgccgacgc gggctcggct gcgaaggcga cggggagcag ggccgggtgc
    16081 cgtgacggtc gggcctgtcg cccgccggtg cgccgcagcc tcagccggag gcgcgtgtcc
    16141 tcgacggcca tggctaccct ccgccaccct tcggccattc tcactcgttc gtgtctcgtc
    16201 gcggaccgtc gccccgggta gagcaccagc cggaggcgag cgaaccatgg aacagactgc
    16261 gttgcggccc aagccgatgc caggtcagga caggcgggac gacggcaccc cgggtgccgc
    16321 ccgccgaccg catgccgcgc cccggcgcgg acggcggcgg cggaccgtgc tgttcggcct
    16381 gtgtgccggt gtcgtgctgg tgctctccgg cgtcggcatc ggcacggtcg gcgccacggt
    16441 gatcggcatg agcagactgg ccgaaccgca gcgcaaggct ccgccgcccg cccagtcggc
    16501 cgaggccacc tccacgacca cctccgccgt cgcacccggc ccggcactgg gcgtggaggc
    16561 cgtcgacgcc gagaaggcgg gcgcgctggt ggtgggtgtg cacgtgcccg gccccggcta
    16621 cgcggccggc ctggtccgcg gggacgtcgt gctgcaactc ggcgcggccc gcatcgacag
    16681 cgccgccgac ctcgcccgcg ccgtcaggcg ggccggcccg gggaaggcgc tgctcctcac
    16741 cgtgcgccac cgcagcggcg gctaccagca gttgacggtg acgcccgcgg tggtgacctg
    16801 accgagccgc gatccggccg gtgcggggcc gccccccgac ggacgggacg ggaccgcctc
    16861 cgggcggccg ggtgccgggg gaggagcggc gggccagtgg tcccggcgtc gggccgcccc
    16921 ggtgccggcg gtgacgtccc ggttgcagac gtggcccagt tcgtggccga tgccgccgcg
    16981 cggttcgcgc ccgtcccgta cacgccggga aacccgctgg tcaccgtgcg tcccgcgggt
    17041 catcatgggc ccatgccgag ccgcttctcc acggaccgcg ggacaccggt ccccgggacc
    17101 ggctcgcgtc gccccgtccg ggcgggcagg atgctgcccg agacgccgtc gccccgtttc
    17161 ctcacccgtg cccggaggcc cggatgaccg gtaccacgcc cgcgcccttc accgccgccg
    17221 actacagcgc ccggatggag cgtgccgcgc gcgccgccgc cgacgccggc ctcgccgggc
    17281 tgctcgtggc cccgggtccg gacatggtgt ggctcaccgg ctacacgccc accgcggtca
    17341 cggaacggct caccgtgctg gtcctcgccc ccggccggga ccccgtgctg gtcgtgccca
    17401 ccctggaggc cccggacgcc gagcacgcgg ccggcgccgc cgcgctgacc ctgcgcgact
    17461 ggaccgacgg caaggacccc tacgccgtca ccgccggcct cctcgacgac cgcggccgct
    17521 tcggcatcag cgacaacacc tgggcgatgc atctgctggg cctccagcgg gccctccccg
    17581 acacctccta cgcctccctc accgacgccc tgcccatgct ccgcgcggtg aaggacgcgg
    17641 ccgagctgga actcctcgca gccgccggag cggctgccga cgcaacgttc gaggagatcc
    17701 ggaaagttcc cttcgcgggc cgccgggagt ccgacgtcgg tcacgacctc gccggcctgc
    17761 tgcgccgctt cggccactcc caggtcgact tcaccatcgt cggctccggg ccgaacggcg
    17821 ccaacccgca ccacgaggtc ggcgaccgcg tcatccagcc cggcgacatg gtcgtcctcg
    17881 acttcggcgg cctgaaggac ggctacggct ccgacaccac ccgcacggtc cacgtcggcg
    17941 agccgaccga ggaggagcgc cgggtccacg acgtcgtgcg cgccgcccag gaggccggtt
    18001 tccgggccgt aggaccgggc gtggcctgcc aggaggtcga ccgcgccgcc cgcgcggtga
    18061 tcgcggacgc cgggtacggc gagtacttca tccaccgcac cgggcacggc atcggcgtca
    18121 ccacgcacga gccgccgtac atgatcgagg gcgaggagca gccgctggtg cccggcatgt
    18181 gtttctcggt ggagcccggc atctacctgc ccggccgctt cggggtgcgc atcgaggaca
    18241 tcgtcaccgt gaccgaggac ggcggccgcc gcctcaacaa caccacccgt gagatggtca
    18301 tagtggactg agaggcccga ggagaacccg tcacgacgac acccggaacg gcgacgcgcg
    18361 acccatgacc caggcaccga cacccaccgc ggacaccgtc cgccgactgg tccgttcgct
    18421 gctcaaggag ggcggcgacg atgccggggg acccgatgtg cggcccgtga cggaggaccg
    18481 cgagcacacc tggtggatcg gcagccgcca tgtgctgcgc ctcgcgcccg accgggaggc
    18541 ctccgtccgc cgccgccggg aactgcgcct gcgcgacctg atccgcccgc acgtgcccgt
    18601 cgccgtgccg accagcgtcg cgcacggcga ctgggcgccc ggcctcgcct acacgctcga
    18661 cacccgggtg cccggcggta cggccgacga gtacgacgtc tcggccgtcg gcgaggccga
    18721 tctcgccggg ctgctgagcg ggctgcgcgc ggtgcccgca cgccaggcgg aggcgctcgg
    18781 cgtgccgcgt acggcgccgc gctccctgga ggcgttgcgc aggatggccg tgcacgcggc
    18841 agaacggctc gccgccgccg acgagttcga cgcggcccgg ctgcaccagc tgaccccgcc
    18901 cggcgcggcc cagctcgccg cgcagcccgg taccgccgtc ctcacccacc acgggctgac
    18961 cggcgcgcac gtggtggtca gcgccgacgg ccgggtgcgc ggcatcctgg actggaccgc
    19021 ggcggccctc ggcgaccccg ccgaggacat cgccggcctc gccgtcgcgg tcggctcccc
    19081 gccggccgtc cgcgccgcca ccctcgccgg ctacggcgcc cgcccctgcc tgcgcggcct
    19141 gtggctggcc cgctgcgaca ccgtcatccg cctcaccggc cacctggagg gccgcaccgg
    19201 cggctcgctg cccctgctgc gcacccagct gcggcgcgcc tgggagccga tcctgctgga
    19261 gcgggtgacg gacttccagg aggacgcccc ggagccctga cgcgggcccg gagcccccag
    19321 gcggtccgcc ctggcgcctg ggcccttgga caacccctca aggcctccct ctcgcccgca
    19381 gggcccctca gggctgggtc agcaccacgc acgactcccc gggcacctgg agcagcccgt
    19441 ccgggcccgg tgcctcgacc gggtcccagg ccgcgaggac gtccacccgg ccggtgccca
    19501 gcgggatcgc cgcctcctgc ctgcccaggt tcaccgccac ccgtacgtcc ccgcgccgga
    19561 aggccagcca gcgggcgtcc gcgtcgtacg ccaccttcgt gtcggcgagg tccgggtcgg
    19621 tgaggtcggg ctgttcccgg cgcagcgcga ccagccggcg gtaccaggcc agcacgcgcg
    19681 cgtggggctc gcgttccggc tccgaccagt ccagacagga ccgctcccgg gtcgccgggt
    19741 cctgcgggtc gggcacgtcc tcctcggccc acccgtgcga ggcgaactcc cgccgcctgc
    19801 cccgccgtac cgcctcggcc agctcggcgt cggtgtggtc ggtgaagaac tgccagggcg
    19861 tgcccgccgc ccactcctcg cccatgaaca gcatcggcgt gaacggcgcg gtcagcgtca
    19921 gcgtggccgc gcaggccagc agaccggggg agacgagggc ggagagccgg tcgccctggg
    19981 cacggttgcc gacctggtcg tgggtctggc tgtagcccag cagccggtgc ccggccacgc
    20041 gcgcgcggtc cagcggccgg ccgtggctgc ggccccggaa gctggagtac gtgccgtcgt
    20101 ggaagtagcc gccggtgagc gtcttggcga gcgcgccgaa ggggtcccgc gcgaagtcgg
    20161 cgtagtagcc ctgcgactca ccggtcagcg cggtgtgcag ggcatggtgg aagtcgtcgt
    20221 tccactgcgc gtgcaggccg aggccgtgct ccgcgcgcgg ggtgatgaac cgcgggttgt
    20281 tcaggtccga ctcggcgatc aggaacagcg gcctgcccac ctcgtccgcc aggccgtcca
    20341 cggccgccga cagctcctcc aggaagtggc acgcgcgcgt gtcgtacaga ctgtgcaccg
    20401 cgtccagccg cagcccgtcg atccggtagt cccgcagcca cgccagcgcg ctgcccagga
    20461 ggaacgcgcg cacctcgtcc gagccgggcg cgtccaggtt caccgccgag ccccacgggg
    20521 tggtgtgcgt gtcggtgaag tacggcccga accgcggcag atagttgccc gacgggccca
    20581 agtggttgtg cacgacgtcg agtacgacgc ccagaccgag cccgtgcgcc cggtcgacga
    20641 agcgcttcag ggcctcgggg ccgccgtacg gctcgtgcac agcccacagg gacacgccct
    20701 cgtaccccca gccgtgccgc ccggggaagg gacacagcgg catcaactcc acgtgggtca
    20761 cgcccagttc caccaggtgc tccagacggg cggcggccgc gtccagggtg ccctcgcggg
    20821 tgtacgtgcc cacgtgcagc tcgtacagca ccgcgcccgg cagcccgcgc cccggccact
    20881 gcgtgcgcca ctcgtggcgc ccgtggtcca cgaccgcgct cagcccgtcc gggccgtccg
    20941 gctggcggcg cgagcgaggg tccggcagca ccgggccgtc gtccagcgag aacccgtacc
    21001 gcgcgccgtc ctgcgcctcc gtctcgcccg tccaccaccc ctcgcgcgcg ggatcgcgcg
    21061 ccaacgcgcg cgtggtgccc tcgcaatgga gcgtcactcg gtctgcctgc ggtgcccaca
    21121 cctcgaactg cacggacggt tccccttcgt ctgctcaccg tgatgtcccg cgtctccatc
    21181 gtgccgcccg gacgatcaat ccgctttcga atccgccctt tgccggcagg tgtcgcggaa
    21241 ctgcccgccc acccgcaccg attccgcgtt ttctggacac tcgcggttca ctgcccgaca
    21301 atcacctgcg tgacgtcgtc cttcgagttc tccacctacc ccgcgcgtct gtccgacgag
    21361 gagcgggaca aggcgctgcg ggtgctgcgc gacggcgtcg ccatgggccg gctctcgcac
    21421 gacacgttcg tccgccgcat ggagctggcg ctcgtcgccc gccgctccga cgaactcgcg
    21481 gccctcgtcg ccgacctgcc ccgggagaat cggttctccc gcgcggtcct cggcaccgtg
    21541 gaagccgtct ccgggttcac cgtgcggctg cgccgggcct ggcaggccga gcggctgccc
    21601 aagctgctgc tgccgcagcc gtcgcacacc cacccgctgc gcatcggccg cgatcccgcc
    21661 aacggactgc gcctgaacca cgagaccgtc tcccgcgtgc acgccgaact ccgccatcag
    21721 ggcggcctgt ggatcctccg ggacctgggc tccaccaacg gcaccaccgt caacggccgc
    21781 cgggtgatcg cggcggtcgt cgtccgcgag ggcgaccagg tcgccttcgg ccgggcggcg
    21841 ttccggctcg cggcccgctg accggcccac cccggtcgaa ctggtgcccg gtcacgcgcg
    21901 cgtaccctcc cgatcgggtg agccgcactg cggaagccgg gccgccgtgc cgatggaacg
    21961 ggcatgacgt acctcaccaa agcggcagcg gcggccggcg ccctgctggc cgccaccggc
    22021 cttctcaccg cgggcccggc ccgggcggcc tcccgcggcc ccctcccgga caactggctc
    22081 tacctgacgg tcaccaaggg cgacgcccgg tcctccgaga cccgcggcac gctgctgctg
    22141 tgcgacccgc ccctcgggca cgc
//
