LOCUS       NZ_CP071839            24547 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 6545353
            Orig. end                         :: 6569900
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..24547
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="21"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..24547
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..24547
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:14547]"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14547
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(96..116)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 19.03"
                     /tool="antismash"
     misc_feature    complement(741..756)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.43"
                     /tool="antismash"
     gene            1081..2748
                     /locus_tag="S1361_RS29455"
                     /old_locus_tag="S1361_29435"
     CDS             1081..2748
                     /EC_number="3.1.3.16"
                     /GO_function="GO:0004722 - protein serine/threonine
                     phosphatase activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004992109.1"
                     /locus_tag="S1361_RS29455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29435"
                     /product="PP2C family protein-serine/threonine phosphatase"
                     /protein_id="WP_243769345.1"
                     /transl_table=11
                     /translation="MSSSPGTSARPPDAGHTVGATWTEAPCPVLIVDRHGGLVDVNGAA
                     RTLLPGAASGDWLHEHVPSWLCDAHQRISDGLRGARAEPLSGPIRERHFEAHPTAAGDG
                     DVVWWLLDDTDRRLAEAALTDAQTRTEILSQVSSRLLSTLNVPRCMEVTASMAAEHIAD
                     AAVLVAPPKGRRHPLTYAVRGGPVTQVTRLVDVSGVPGLTEALQGFPPVPARWINPADI
                     PDWVAPDGFAGPVGSVIVAPLPGHGVPAGALILVRSSTEQSFTEGEEVFARLFAARAGA
                     ALSAARLYGEQATVTATLMRELLPPPLSSVHGVEYAGGYRAAKDHERVGGDFYDVHPGS
                     DPSQDTLVVLGDVAGKGLDAAVLTGKIRNTLHALLPLTDDHQRVLDLLNGALLTSRHAR
                     FATLVLASVRRRGSRAQLRLTSAGHLPPLIVRADGTVEEVPAHGTLVGALPAVTAHTVR
                     MVLAPGDTCLLYTDGITEARGGPLGDEFFGEHRLRRALAECAGLPAEAVVERVQMLAAE
                     WLGGGRHDDMAAVAISVPRTGPLTVLHGRAGAKNRRRT"
     gene            2745..3833
                     /locus_tag="S1361_RS29460"
                     /old_locus_tag="S1361_29440"
     CDS             2745..3833
                     /GO_function="GO:0031419 - cobalamin binding [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_017948555.1"
                     /locus_tag="S1361_RS29460"
                     /note="Presence of a B(12) (cobalamin)-binding domain
                     implies dependence on cobalamin itself, in one of its
                     several forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog.; Presence of a B(12)
                     (cobalamin)-binding domain implies dependence on cobalamin
                     itself, in one of its several forms, or in some unusual
                     lineages, dependence on a cobalamin-like analog.; Presence
                     of a B(12) (cobalamin)-binding domain implies dependence on
                     cobalamin itself, in one of its several forms, or in some
                     unusual lineages, dependence on a cobalamin-like analog.;
                     Presence of a B(12) (cobalamin)-binding domain implies
                     dependence on cobalamin itself, in one of its several
                     forms, or in some unusual lineages, dependence on a
                     cobalamin-like analog; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29440"
                     /product="cobalamin-dependent protein"
                     /protein_id="WP_208034919.1"
                     /transl_table=11
                     /translation="MRHPTGAADLPDRLWQAVADGDEYTAVDILHKAAADGVDEETLLL
                     EVIAPVQEKAGAEWAAGRITVAQEHAATAISERVVATLAHRRAGPGRHAPDRGRVTVGC
                     VDGEWHAFPARLVAEVLRLRGWRVDYLGARIPTPHLVAHLHGTDPDAVLLSASVPTRLP
                     TAHVAVTACQAVGVPVLAGGRAFGADGRHARLLGADGWAADARGAAAVLETGLARPGPA
                     AIRQVADDLPHLADQEYTMVVQSRPLLVKQTLADLETRFPAMRGYDDAQREHTAQDLAH
                     IVDFLATALYVDDPGIFTAFLTWTAEILEARHVPARSVATGLDLLAGQLREFPRTLGLL
                     HAGSAVVAARPTRPVPGPHPKA"
     gene            3830..4228
                     /locus_tag="S1361_RS29465"
                     /old_locus_tag="S1361_29445"
     CDS             3830..4228
                     /GO_function="GO:0043856 - anti-sigma factor antagonist
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013868.4"
                     /locus_tag="S1361_RS29465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29445"
                     /product="STAS domain-containing protein"
                     /protein_id="WP_208034920.1"
                     /transl_table=11
                     /translation="MTNLHPTEFTVTVYRTAGTLTVRVAGELDYDTSDGLTDMVARHLT
                     ADQAEPSDVRLDFRDLTWIDSSGLTALLVVRRRTAAVGATLHLDHRPDVLERMLRLTNV
                     LDHLTAPASGEGTTDRQEEDGITGTSVN"
     gene            4323..4493
                     /locus_tag="S1361_RS29470"
                     /old_locus_tag="S1361_29450"
     CDS             4323..4493
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014676019.1"
                     /locus_tag="S1361_RS29470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29450"
                     /product="hydrophobic protein"
                     /protein_id="WP_208034921.1"
                     /transl_table=11
                     /translation="MVPLLLVLLLALILFGAGFALKVLWWVAVAVLVLWLLGFVMRSTT
                     VGGGRSRWYRW"
     gene            4688..6235
                     /locus_tag="S1361_RS29475"
                     /old_locus_tag="S1361_29455"
     CDS             4688..6235
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016823972.1"
                     /locus_tag="S1361_RS29475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29455"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_243769346.1"
                     /transl_table=11
                     /translation="MEDARLCLVTGAAGYIGGRLVPELLDAGYRVRCLVRTPRKLRDQP
                     WAGRVEVVRGDVTDAGSVAAAMEGVDVAYYLVHALGTGRDFEQTDREAARVFGEQARGA
                     GIGRLVYLGGLTPAGVPERELSPHLRSRAEVGRILLGSGVPTAVLRAAVIIGSGSASFE
                     MLRYLTERLPVMVTPRWVRTRIQPVAVRDVLRVLVGCAGLPADVSRAFDIGGPEVLTYV
                     EMMRRYAAVAGLPRRLIVPVPVLTPGLSSQWVGLVTPVPAALARPLTESLRHEVVCRER
                     DIERYVPSPPGHPIGFDRAVALALERVRDAQVATRWSSASVPGAPSDPLPTDPDWAGGS
                     LYTDVRERHAEAAPAALWDVVEGIGGENGWYSFPLAWAVRGRLDRLAGGVGLRRGRRDA
                     RRLRVGDSLDFWRVEEIERGRLLRLRAEMRLPGLAWLEMHVDADGAGGARYRQRAVFHP
                     HGLLGQLYWWSVSPFHAVVFGGMARNIVRAAERVQQRGTAARPGDADRPGTASHERG"
     gene            6241..7617
                     /locus_tag="S1361_RS29480"
                     /old_locus_tag="S1361_29460"
     CDS             6241..7617
                     /EC_number="4.1.99.3"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003904 - deoxyribodipyrimidine
                     photo-lyase activity [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018566613.1"
                     /locus_tag="S1361_RS29480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29460"
                     /product="deoxyribodipyrimidine photo-lyase"
                     /protein_id="WP_208034922.1"
                     /transl_table=11
                     /translation="MRVSVVLFTSDLRVHDHPPLRAALAAADAVVPLFVRDRAVAAAGF
                     ATPNRSAFLADCLTDLDAALRERGGRLVVRSGDLVEEVCRAAREADADEVHLAAAHSRF
                     ATRREERLRRALESDGRRLSVHDAVTVAVPPGEVTPASSDHFAVFTPYLRRWTQVPLRA
                     ALDAPRRVPVPDHVRGEPLPARGSVPGVSPALAPGGESEGRRRMTAYWRTGLDAYDDTR
                     DDLAADATSKLSAHLHFGTLSAVELVHRARRHGGPGAEALVRQLVWRDFHRQVLAARPD
                     AAHTDYRTRHDRWRTESTARDDIEAWQEGRTGYPVIDAAMRQLRHEGWMHNRARLLTAS
                     FLTKTLYVDWRIGAAHFLYWLVDGDVANNQLNWQWVAGTGTDTRPNRVLNPVTQAKKYD
                     PGGAYVRRWVPELRGVECPAVHEPWKLPGPDRAALDYPDPVVGLAEGLERFRRARARPQ
                     "
     gene            complement(7639..9201)
                     /locus_tag="S1361_RS29485"
                     /old_locus_tag="S1361_29465"
     CDS             complement(7639..9201)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012998484.1"
                     /locus_tag="S1361_RS29485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29465"
                     /product="NAD(P)/FAD-dependent oxidoreductase"
                     /protein_id="WP_208034923.1"
                     /sec_met_domain="DAO (E-value: 3.1e-15, bitscore: 55.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRAGRPLPRPGRDRLARLLPAPPGALRADPASAPRAAVVGGGI
                     AGLSAATALAERGVRVTLYEREETLGGRLAGRPTRLADGSTVTMSRGFHAFFRQYYNLR
                     ALLRRTDPALSRLTGLPDYPLRHADGARDGFRHVPRTPPLGALGFVALSPSFRVRDLAR
                     INVRAALGLLDVRVPEVYDRLDATSAHDLLEEIRFPAAARHLAFEVFSRSFFADPRVLS
                     AAEMALMFHIYFLGSAEGLLFDVPTEPFPQALWDPLAGYLARRGALLRTATAVESVTAL
                     PGGGFAVAAGGGEEHCDAVVLAADPGALRALVARSADLGDEPWRERIARLRTAPPFLVS
                     RLWLDRPVRGDRPGFLGTSGYGPLDNVSVLDRWEGEAARWAARTGGSVVELHAYALPGD
                     TDRERWQKELLAALHRLYPETGRARVVDARHEWRADCPLFPVGGHGDRPTVRTPVPGLV
                     VAGDTVRTDLPVALMERAATSGFLAANTLLERWGLRGHPLWTVPGGGRWAALRRAARAT
                     RRG"
     gene            complement(9198..9980)
                     /locus_tag="S1361_RS29490"
                     /old_locus_tag="S1361_29470"
     CDS             complement(9198..9980)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987735.1"
                     /locus_tag="S1361_RS29490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29470"
                     /product="methyltransferase"
                     /protein_id="WP_208034924.1"
                     /transl_table=11
                     /translation="MPPSPRTPRTRPPLLRDAELAGAFDHAARSYDTLVAANPGYHAQL
                     RRSVRRLGLPPDGSGLRVLDLGCGTGASTAALAAVLPGADITAVDASAGMLRRAAARRR
                     PRPVRFVHAPVERLAEAGVQGPFDAVFAAYLLRNTADPDAVLATARRLLAPHGRLAVHE
                     YALSGRAVHRAVWTAVCGGLLLPVATLLGDGPLYRHLWHSVVAFDTAGALGRRVERAGF
                     ERVRVLPLPGWQTGITYTVVARRPDEAGCGGVDAEGPR"
     gene            complement(10001..11203)
                     /locus_tag="S1361_RS29495"
                     /old_locus_tag="S1361_29475"
     CDS             complement(10001..11203)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: Lycopene_cycl"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016471648.1"
                     /locus_tag="S1361_RS29495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29475"
                     /product="lycopene cyclase family protein"
                     /protein_id="WP_208034925.1"
                     /sec_met_domain="Lycopene_cycl (E-value: 5.9e-95, bitscore:
                     317.4, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELEADVAVVGAGAAGLSLALRLARPPAHARRLDTVLLAAPPGPG
                     RAAPRTWCFWEPDGGPYDEALTASWQRLRVHGADGAAVTAGIAPLHYKMLRSDAFEELA
                     GRAMAASGGRVARVDAAVGRITPAPGGGALVHARRADGTRVAVRARRVFDSRPLPRLPP
                     ARTTLFQHFRGWFVRTARPVFDPSVVELMDFRTPQPAHGLSFGYVLPVGPCEALVEYTE
                     FSGRLLDRAGYDRALRDYAGRVLGLEGYEVTGCEQGVIPMTDAGFPRRAAPDVYRIGAC
                     AGATRPSTGYTFSAVQRQTAAVAAALHSGRRPLPPRPHSARARLMDAVLLHALDRGRVD
                     GPAFFTRLFTRVPAPRLLRFLDGRTGLAEDLGIGAHVPVAPMLASALTLPFVPRRTSPA
                     A"
     gene            11438..11722
                     /locus_tag="S1361_RS29500"
                     /old_locus_tag="S1361_29480"
     CDS             11438..11722
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS29500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_29480"
                     /product="hypothetical protein"
                     /protein_id="WP_208034926.1"
                     /transl_table=11
                     /translation="MRCTQDTHRDPEPPGARPRHARGHHRAAGRGPSGACALSAGVTGV
                     FGACVSPAGVTGLSGACVPPTGVTGAFGQLPGPAGGMPGAAAHGYGGVR"
     gene            11719..13260
                     /gene="crtI"
                     /locus_tag="S1361_RS29505"
                     /old_locus_tag="S1361_29485"
     CDS             11719..13260
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0016166 - phytoene dehydrogenase activity
                     [Evidence IEA]"
                     /GO_process="GO:0016117 - carotenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="crtI"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222: dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006607880.1"
                     /locus_tag="S1361_RS29505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29485"
                     /product="phytoene desaturase family protein"
                     /protein_id="WP_208034927.1"
                     /sec_met_domain="DAO (E-value: 3.7e-16, bitscore: 58.4,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRAVKGPTDHVVVVGAGLAGLSAALHLLGAGRRVTVVERDAGPG
                     GRAGRIERGGYLIDTGPTVLTMPEIADEAFAAVGASLYDHVELIPLHPAYRARFADGSS
                     LDVHTDADAMEAEVERFAGPGEAAGYQHLRHWLSELYRAERHRFLDADFDSARQLLGPG
                     LLRLALLGGFGRWEAAVARHLRDERLRRVFTFQALYAGVPPARALAAYAVIAYMDTVAG
                     VCFPRGGMHALPRAMAEAAAEAGAVFHYGHAVTRLERSGDRVTAVIAGHQRIPCDAVVL
                     TPDLPVTYRLLGRTPRRPLRLRHAPSAVVLHAGCDRTWPELAHHTLSFGRAWRRTFDEL
                     TRTGDLMSDPSLLISRPTATDPALAPPGRHLHYVLAPCPNSAIGPRAADWTDLGPRYRD
                     SVLRTLDRRGLAGIAAAIEEECLVTPADWAAQGHAAGTPFSAAHTFAQTGPFRPRNLVR
                     GTANAVLAGCGTTPGVGVPPVLLSGRLAAARLTGTARTTTPRPAGTPARPAGARA"
     gene            13310..13528
                     /locus_tag="S1361_RS29510"
                     /old_locus_tag="S1361_29490"
     CDS             13310..13528
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS29510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_29490"
                     /product="hypothetical protein"
                     /protein_id="WP_208034928.1"
                     /transl_table=11
                     /translation="MERRPARQEPAHDLEHRGAGPRGRSRAYGMERRDARQEPAHDPQR
                     RGAGPSEGSGRMTRRAGAQARVQEVWS"
     gene            13525..14547
                     /locus_tag="S1361_RS29515"
                     /old_locus_tag="S1361_29495"
     CDS             13525..14547
                     /EC_number="2.5.1.-"
                     /GO_function="GO:0004659 - prenyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0008299 - isoprenoid biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: phytoene_synt"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_phytoene_like"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987731.1"
                     /locus_tag="S1361_RS29515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29495"
                     /product="phytoene/squalene synthase family protein"
                     /protein_id="WP_208034929.1"
                     /sec_met_domain="phytoene_synt (E-value: 1.3e-115,
                     bitscore: 384.1, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PT_phytoene_like (E-value: 1.4e-61,
                     bitscore: 207.2, seeds: 61, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTARELDAAGVAGAELRAAYTRCRELNARHGRTYFLATRLLTPGR
                     RPAVHALYGFARWADDIVDSLDSTAGPHARARALDRLDADLARGLAGGTGAEPVVRALA
                     DTARRYAIDHHHFADFLAAMRSDLTTVSYATYTDLRRYMHGSAAVIGLQILPVLGTVAP
                     RRQAEPYAAELGVAFQLTNFLRDVGEDLDRGRVYLPEDLLAAHGVDRALLRHCRATGRS
                     EPHVVRALREFASLTRAAYRRAAPGIDLLDPVSRPCIRTAFVLYGGILDAVAGTGYAVL
                     HRRAAVPRRRRALVAADGLVRVTAARTAARLAGRRAVPPAVPPAPRTAARSPRGHEEVT
                     "
     gene            14544..15554
                     /locus_tag="S1361_RS29520"
                     /old_locus_tag="S1361_29500"
     CDS             14544..15554
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987730.1"
                     /locus_tag="S1361_RS29520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29500"
                     /product="DUF5914 domain-containing protein"
                     /protein_id="WP_208034930.1"
                     /transl_table=11
                     /translation="MSPAPPSRPRRLPLGLRRAPVAWERQRPTWREARPALIAEALERA
                     LARPAGNWYVVGASRGLRPGRPLARTVAGREIVLWRNGEGRPVAGPGSCPHLGAPLGDG
                     AVRCGTLVCRWHGLALDGGPFAGWEPYPAHDDGVLLWVRLDKAGADPPTGRPPVPERPA
                     VAGALTAVYTGVGRCEPDDVVANRLDPWHGAWFHPHSFADLTVVGVPGPDGDGDAFTVD
                     VSFRVTGRLVVPVRAVFTAPGPRTVVMRIVRGEGEGSVVETHATPLGPDVLGRPRTAVV
                     EAVVATSGRPGFTAVRHAAPLLRPLVRAAAARLWRDDLAYAERRWTLRSSGRLPG"
     misc_feature    complement(16274..16292)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 20.31"
                     /tool="antismash"
     misc_feature    complement(16277..16292)
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 18.64"
                     /tool="antismash"
     gene            16278..17225
                     /gene="sbnA"
                     /locus_tag="S1361_RS29525"
                     /old_locus_tag="S1361_29505"
     CDS             16278..17225
                     /GO_function="GO:0030170 - pyridoxal phosphate binding
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="sbnA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PALP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1081: cysteine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003983342.1"
                     /locus_tag="S1361_RS29525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29505"
                     /product="2,3-diaminopropionate biosynthesis protein SbnA"
                     /protein_id="WP_208034931.1"
                     /sec_met_domain="PALP (E-value: 3.2e-51, bitscore: 173.3,
                     seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFRNAYDLVLDDLFLDLSGFVPGVDLTLKIEGLNLAGSIKLKAA
                     VGLLEDLERRGLLKPGGRVIESSSGNLGIALSSVCAARGYRFTCVADPNTATTSVRLMR
                     AYGADVVIVDRRDANGGFLQSRIDHIHARLREDPGLVWPNQYANKANPQAHYRRTAPAL
                     LKEREVDVLFVGAGTTGTLRGCAEYFREHSPGTRIVAVDTAGSVTFGSSPARRHIPGLG
                     TSRRPEIFRDGLVDEVVMVPEAEAVRMCRRLATGRGVLAGGSTGSVLAAVETRHRDIPE
                     GASVVAISPDLGERYLDTIYDDDWVGERFGAVDD"
     gene            17288..18295
                     /gene="sbnB"
                     /locus_tag="S1361_RS29530"
                     /old_locus_tag="S1361_29510"
     CDS             17288..18295
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="sbnB"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1158: ornithine cyclodeaminase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014179378.1"
                     /locus_tag="S1361_RS29530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29510"
                     /product="2,3-diaminopropionate biosynthesis protein SbnB"
                     /protein_id="WP_208034932.1"
                     /transl_table=11
                     /translation="MFEFDVVTGRTVRDIVRDSRRDIVRVVRDTYLAHHAGRSVNPDSY
                     FLRFPEKPADRIIALPAYLDGEREVAGIKWIASFPANIERGIPRASATLVLNDAETGYP
                     FALLEASQISAARTAASAVLAADVLTGGRKGGRLAVVGAGIIARNILEFFHAEQWTFEQ
                     VAVHDLSQEYGTALAAHATERLAYPASYAETLQGAVSGADVVVFATTAGEPYVLEPGAF
                     APGQIVLNISLRDIGAEIIAGSYNVLDDVDHCLKANTSPHLAEQKYGNRDFVTGTIAEV
                     INGEVTVGTDKPVVFSPFGLGVLDLAVGLEVHRVAAESGRVTAIADFFGETERW"
     gene            18292..20202
                     /locus_tag="S1361_RS29535"
                     /old_locus_tag="S1361_29515"
     CDS             18292..20202
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024846.4"
                     /locus_tag="S1361_RS29535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29515"
                     /product="FAD/NAD(P)-binding protein"
                     /protein_id="WP_208034933.1"
                     /transl_table=11
                     /translation="MTTSLRRTPVAGTVGIIGLGSRGIGVLERLVTRAARPDWAGRRLV
                     VEVVDPDGTGVGIHTVDQPDHLLLNTICTQVSLFPEEATVGAAVGDRGPDLYTWVTDRG
                     LKVADDGHTLGDEGRPVRPDDYLPRRVLGEYLAWFLRRLLDRVPENVEIRFHRATATGL
                     SAGPDDSRRITLDTGETLPVDSVFLTTGHTPPAAPDPEAPGASRRIHEIYPPAAAFAAV
                     TAGRTLALGGTGLSAMDVLASLTLGRGGRYEAADGGLRYLPSGREPRVLLFSRTGIPFR
                     ARPAANRTGGPYRPVVFTPEALDRLRSTGDDRPLSLRGDLLPLLRTEMRIAFHRHGAAL
                     ARGTEAEGALTAKLRAAADAGTLDDELRALDLAHAERFGHFDPQDLLFPDGAESDSSDA
                     YQKWYEERLRSDLVEARLGLGGSPTKAGLEVLRDLRDVVRHAVDFGGLDEDSHDEFYGS
                     FTATLNRSVTGPQLDRHEELLALLEAGIVSVPFGPAPRVEWDGTAWRISSTRLGTGHSA
                     RADWLAYATSGQPDVEATGSPLLADLVAGGRLCRHRPGARSSLGVDITADQHPVAADGR
                     PDRKVRVLGPLCEGATFYNHYVPSPGGRNRALADADRCVTAVLAELAAATEPETTRSPE
                     Q"
     gene            20199..21128
                     /locus_tag="S1361_RS29540"
                     /old_locus_tag="S1361_29520"
     CDS             20199..21128
                     /EC_number="2.3.1.46"
                     /GO_function="GO:0004414 - homoserine O-acetyltransferase
                     activity [Evidence IEA]"
                     /GO_function="GO:0008899 - homoserine O-succinyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019281 - L-methionine biosynthetic process
                     from homoserine via O-succinyl-L-homoserine and
                     cystathionine [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016120.4"
                     /locus_tag="S1361_RS29540"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29520"
                     /product="homoserine O-succinyltransferase"
                     /protein_id="WP_208034934.1"
                     /transl_table=11
                     /translation="MTLIVPTRIDAVDQLTEEGIAVTVEPRGAGAAIPAVELAILNLMP
                     DKPVTETQLLRLLSGAGLPVRVTLLRPRDHVSRSTPETYLKEHYQTHEDVADRRFDALI
                     VTGAAVELLPFEQVTYWDELRGIMDWAQEHVTSTQYVCWGAQAALYHRYGIPKHELPAK
                     LFGNFPNRLTDPSSPLLADFEPVVAVPQSRHTENLRADFEKTGELRILVESPESGVHIA
                     AGRDGRELYVSGHPEYDPDTLLRQFRRDQAKGADIALPVNYFPDDDPSADPVENWQDHG
                     RLFYRNWLRGLTRGGIPLADITAEKSGV"
     gene            21131..21766
                     /locus_tag="S1361_RS29545"
                     /old_locus_tag="S1361_29525"
     CDS             21131..21766
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1116:
                     Homoserine/threonine efflux protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020554703.1"
                     /locus_tag="S1361_RS29545"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29525"
                     /product="LysE family translocator"
                     /protein_id="WP_208034935.1"
                     /transl_table=11
                     /translation="MSVLQSLVSFALVSALLVIMPGVDTALVIRNTVARGRLHGFITGV
                     GVGVGAVIWGAAIAVGIGALLEASETAYTVFRIVGAAYMVWLGIGLWRSARAIGAGQEK
                     DTELEPESASLWRSFGRGMLNNLANPKVGVFYGATIPQFIPSGASPAFMGTALAAVNAV
                     EAIIWYGLISLGAHGLRTWMKRRTVRRNVDATAGTVMIAFGIVMAVES"
     gene            complement(22065..23069)
                     /gene="meaB"
                     /locus_tag="S1361_RS29550"
                     /old_locus_tag="S1361_29530"
     CDS             complement(22065..23069)
                     /EC_number="3.6.5.-"
                     /GO_function="GO:0003924 - GTPase activity [Evidence IEA]"
                     /GO_function="GO:0005525 - GTP binding [Evidence IEA]"
                     /codon_start=1
                     /gene="meaB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007499184.1"
                     /locus_tag="S1361_RS29550"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_29530"
                     /product="methylmalonyl Co-A mutase-associated GTPase MeaB"
                     /protein_id="WP_208034936.1"
                     /transl_table=11
                     /translation="MAAIDLDTYVKGVLDGKRALVARAITLVESTRPQHRALAQQLLTE
                     LLPHSGRARRIGVSGVPGVGKSTFIDAFGTMLTSLGHRVAVLAVDPSSTRTGGSILGDK
                     TRMERLAVDPDAFVRPSPSAGTLGGVAKATRESMVVMEAAGYDVILVETVGVGQSETTV
                     AEMVDSFLLLTLARTGDQLQGIKKGVLELADVIAVNKADGPHERDARAAARELAGALRL
                     MHGKDAFWTPPVLHCSARESTGLDTVWERLEQHRTLLDSTGRLAAKRRDQQVGWTWAMV
                     RDELLGRLHSDPAVRATAPDLERQVREGRLTATLAAERILAAFEGRTPPSPAG"
     misc_feature    23849..23862
                     /note="TFBS match to ANR, Anaerobic transcriptional
                     regulator, confidence: weak, score: 17.7"
                     /tool="antismash"
     misc_feature    23975..23993
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 18.47"
                     /tool="antismash"
ORIGIN
        1 cttcaccagc tccgcgttga actgggcgcc gaccaggagg gccaggttgg ccagccacag
       61 ccagaccagg aagaccacga cacccgccag cgaaccgtac agccggtgat aggtcgtgac
      121 gtgcgaggtg tagacggcga atccgaggga ggcgaccagc aggagcacca ccgccagggc
      181 gccacccggc gccatcctcc gcaccgggcg ggagggcgcc ggacccgagc ggtagaggac
      241 cagcaccagg gccacggcga ccacggccac gagcggccag cgcagagcgt cccaggcgac
      301 ctgcggcccg gtgcccaggt ccagcgcccg gcccagccgc cgggccaggc cgccggtgag
      361 gaacagcgcc agggtggtcg tcaggagcag cgagatcagg acgagggccg tggcgacgat
      421 ccgcggagcg gtacgccaca acggccggtc cgcactgatg cggtgcatgg agtgcaacgc
      481 ccggcggaag acactcaggt agctggagcc cgaccacagc gctcccgacc ccgccaggaa
      541 gatcagcgtc catgccgtcg acggctgtcc ggccatctgc agcagcgtgc tgcgcagcag
      601 ctcgcgggag gcgaccgggg cggcctgcga catgcggtcg atgacctccg gtttggccgt
      661 cgggacggtc agacccacga tcgagaggat caccagcagg accgggaaca gggccaggac
      721 cgcgtagtac gtcagcgcgg cggcccagtc ggtcacgtcg tcgttccaga cggccaccgg
      781 cgtccggcgc aacgccgccc accaccgtgc cgtacgaccg tctgcgtcct ccacgaggcg
      841 gatgctctca cccccggtgc tcggccgtac cccggccacg actgccggtc gccttcccgg
      901 aaacgccgcc gtcatgcccg gatgtcgtcg tcatggccgc catcggaacg aatgtgatgg
      961 tccggtgcgg ttttccaggg cgggttgcga cggtgggcgc cggtgcggga ctgttgccgt
     1021 aagacatcta tttccccatg gcaggaaggt ggtggggtgc gcacgtgcgt gcctccgctt
     1081 gtgtcttctt cccccggtac ctccgcccgt ccgcccgatg ccggccacac ggtcggcgcg
     1141 acgtggactg aggccccctg tcccgttctc atcgtcgacc gccacggcgg tctggtcgac
     1201 gtcaacgggg ccgcccggac actcctcccc ggtgccgcca gcggcgactg gctgcacgag
     1261 cacgtcccct cctggctctg cgacgctcac cagcgcatca gcgacgggct gcgcggcgcg
     1321 cgcgccgagc cgctgagcgg acccatcagg gaacgccact tcgaggcgca ccccacggcg
     1381 gccggcgacg gcgacgtggt gtggtggctg ctcgacgaca ccgaccgccg cctggccgag
     1441 gccgcgctga ccgacgcgca gacgcgcacc gagatcctct cgcaggtctc cagcaggctg
     1501 ctgtccaccc tgaacgtgcc gcgctgcatg gaggtgaccg cctccatggc cgcggagcac
     1561 atcgccgacg ccgcggtcct cgtcgccccg ccgaaggggc ggcgccaccc cctgacctac
     1621 gcggtcaggg gcgggcccgt cacccaggtc acacggctgg tcgacgtctc cggcgtaccg
     1681 ggcctgaccg aggccctgca gggcttcccg ccggtaccgg cccggtggat aaaccccgcc
     1741 gacatccccg actgggtcgc cccggacggc ttcgccggcc cggtcggctc cgtgatcgtc
     1801 gctccgctcc ccggtcacgg cgtacccgcc ggcgccctga tcctcgtgcg ctccagcacg
     1861 gagcagtcct tcaccgaagg cgaggaggtc ttcgcccggc tcttcgccgc ccgcgccggc
     1921 gccgccctct ccgccgcccg cctctacggc gaacaggcca ccgtcaccgc cacgctgatg
     1981 cgcgagttgc tgcctccgcc gctgagcagc gtgcacgggg tggagtacgc cggcggctac
     2041 cgcgcggcca aggaccacga gcgggtcggc ggggacttct acgacgtcca ccccggctcc
     2101 gacccctccc aggacaccct cgtcgtcctc ggcgacgtcg cgggcaaggg cctggacgcg
     2161 gccgtgctca ccggcaagat ccgcaacacg ctgcacgcgc tgctgccgtt gaccgacgac
     2221 caccagcggg tgctcgacct gctcaacggc gcgcttctca cctcccggca cgcccgcttc
     2281 gccacgctgg tcctcgcctc cgtccgccgt cgcggcagcc gggcccagct ccggctgacc
     2341 agcgccggcc acctgccgcc gctgatcgtc cgcgccgacg gcacggtgga ggaggtaccc
     2401 gcccacggaa ccctggtcgg tgcgctgccc gccgtcacgg cgcacacggt ccggatggtg
     2461 ctggcgcccg gagacacctg cctgctctac accgacggca tcaccgaggc gcgcggcggc
     2521 ccgctcggcg acgagttctt cggcgagcac cgcctgcgcc gggccctggc ggaatgcgcg
     2581 ggcctcccgg cggaagcggt cgtggaacgg gtgcagatgc tcgccgccga gtggctgggc
     2641 gggggccgcc acgacgacat ggccgccgtc gccatcagcg tcccccgaac cggcccgctg
     2701 accgtgctgc acggacgggc gggcgccaag aacaggagga gaacgtgagg caccccaccg
     2761 gggcggccga tctgccggac cggctgtggc aggcagtggc cgacggcgac gagtacacgg
     2821 ccgtcgacat cctgcacaag gcagcggccg acggtgtgga cgaggagacg ctgctcctgg
     2881 aggtgatcgc gcccgttcag gagaaggccg gggccgaatg ggccgccggc cgcatcaccg
     2941 tggcacagga acacgccgcg accgccatca gcgagcgggt cgtcgccacc ctcgcccacc
     3001 gccgcgcggg acccggacgc cacgcccccg accgtggccg ggtgacggtc ggctgcgtcg
     3061 acggcgaatg gcacgccttc cccgcccggc tcgtcgccga ggtgctccgg ctgcgcggct
     3121 ggcgggtcga ctacctcggc gcccggatcc ccaccccgca tctggtggcc cacctgcacg
     3181 ggaccgaccc cgacgccgtc ctgctgtccg cctcggtccc cacccgcctg ccgacggccc
     3241 acgtcgccgt caccgcctgc caggccgtcg gcgtacccgt cctggcgggc ggccgggcct
     3301 tcggcgcgga cggccgccac gcccgcctcc tcggggccga cgggtgggcg gccgacgccc
     3361 gcggcgcggc cgccgtgctg gagacgggtc tcgcccggcc cggcccggcg gcgatccggc
     3421 aggtggcgga cgacctgccg cacctggccg accaggagta cacgatggtg gtccagtccc
     3481 ggcccctcct cgtcaaacag actctggccg acctcgaaac ccgcttcccg gccatgcgcg
     3541 gctacgacga cgcccagcgc gagcacaccg cgcaggacct cgcccacatc gtcgacttcc
     3601 tggccaccgc cctctacgtc gacgaccccg ggatcttcac cgcgttcctg acctggacgg
     3661 ccgagatcct cgaagccagg cacgtgcccg cccgttccgt ggcgaccggc ctggacctcc
     3721 tggccgggca gctccgcgag ttcccccgca ccctcggcct cctccacgca ggcagtgccg
     3781 tcgtggccgc ccgccccacc cgtcctgtcc ccggccccca ccccaaggca tgaccaacct
     3841 gcaccccacc gaattcaccg tcaccgtcta ccgcacggcc ggcacgctca ccgtgcgggt
     3901 ggccggcgaa ctcgactacg acacgagcga cggcctgacc gacatggtcg cccggcacct
     3961 gacggccgac caggccgagc cgagcgacgt acgcctggac ttccgcgacc tgacctggat
     4021 cgactcctcg ggcctgaccg ccctgctggt ggtccgtcgc cgtaccgccg ccgtcggcgc
     4081 cacactgcac ctggaccacc ggcccgacgt cctggagcgg atgctgcgtc tgacgaacgt
     4141 gctggaccac ctcaccgccc cggcgagcgg cgagggcacg acggaccgcc aggaggagga
     4201 cggcatcacc gggacgagcg tcaactgacg gctggtgccc ggtctttccc ttcataaaca
     4261 agccattgtc ggggcgtatg ggtgggattg aagggcagac gggcgccagg aggttgatac
     4321 acatggttcc cctgcttctc gtcctgcttc tggcactgat cctcttcgga gccggcttcg
     4381 cgctcaaggt cctctggtgg gtcgccgtgg ccgtgctcgt gctgtggctc ctcggcttcg
     4441 tcatgcgctc caccacggtc ggcggtggcc gcagccggtg gtacagatgg tgatctgaca
     4501 cccgcacacc ccctcgcagg gcccggccga cggacggccg ggccctgcgt gtgtgcccgg
     4561 caccaccgga cgtcacccgg ttgccgggcg cacccggtgc atccggacgg ccgggaggca
     4621 ccgttgtggg taccgggaga cgagggggcg cgacggcgcc cggacgacta cggaggcggc
     4681 ggtacacgtg gaggacgcga ggctctgtct ggtgaccggc gccgccggct acatcggcgg
     4741 gcgactggtg cctgagctgc tggacgccgg gtaccgggtg cgctgcctgg tgcgcacgcc
     4801 ccggaagctg cgcgaccagc cgtgggccgg gcgggtggag gtcgtgcggg gcgacgtcac
     4861 cgacgccggc tcggtggcgg cggcgatgga gggtgtcgac gtcgcctact acctggtgca
     4921 cgcgctcggc accggccgcg acttcgagca gaccgaccgg gaggcggccc gtgtgttcgg
     4981 cgagcaggcc cgcggggccg gcatcggacg cctggtctac ctgggcgggc tgaccccggc
     5041 cggcgtgccc gaacgggagc tgtccccgca cctgcgctcc cgcgccgagg tggggcgcat
     5101 cctcctcggc tccggcgtgc cgacggccgt gctgcgggcc gccgtcatca tcggctccgg
     5161 gtccgcgagc ttcgagatgc tgcgctacct caccgaacgg ctgccggtga tggtcacccc
     5221 gcgctgggtg cgcacccgca tccagccggt cgccgtacgg gacgtgctgc gcgttctggt
     5281 cggctgcgcc gggctgcccg ccgacgtcag ccgggcgttc gacatcggcg gccccgaggt
     5341 gctgacgtac gtggagatga tgcggcggta cgccgccgtc gccgggctgc cccggcgcct
     5401 catcgtcccc gtgcccgtgc tcacccccgg cctgtccagt cagtgggtcg gcctcgtgac
     5461 ccccgtaccg gccgccctcg cccgcccgct cacggagtcg ctgcggcacg aagtggtgtg
     5521 ccgggagcgg gacatcgagc gctatgtacc cagcccgccc ggccacccga tcggtttcga
     5581 ccgcgccgtc gccctcgcgc tggagcgcgt gcgcgacgcg caggtcgcca cccgctggtc
     5641 ctccgcctcc gtaccgggag cgcccagcga cccgctgccc accgacccgg actgggcggg
     5701 cggcagcctc tacaccgacg tacgcgaacg ccacgccgag gcggctccgg ccgcgctctg
     5761 ggacgtcgtc gagggcatcg ggggcgagaa cggctggtac tcgttcccgc tggcctgggc
     5821 ggtgcgcggc cggctcgacc gcctcgccgg cggagtgggc ctgcgccggg gacgccggga
     5881 cgcccgccgg ctgcgggtgg gcgactcgct ggacttctgg cgggtggagg agatcgagcg
     5941 cgggcggctg ctgcggctgc gcgccgagat gcggctgccc ggcctggcct ggctggagat
     6001 gcacgtcgac gcggacgggg ccggcggcgc ccgctaccgg cagcgggccg tgttccaccc
     6061 gcacgggctg ctcggccagc tgtactggtg gagcgtgtcg cccttccacg cggtcgtctt
     6121 cggcggcatg gcccgcaaca tcgtccgtgc cgccgaacgc gtgcagcagc gcggcaccgc
     6181 cgcccggccg ggcgacgcgg accgacccgg caccgcgtcc cacgagagag gctgacaccg
     6241 atgcgtgtct cggtcgtcct gttcacctcc gacctccgtg tgcacgacca cccgccgctg
     6301 cgcgcggccc tggcggccgc cgacgcggtc gtgccgctct tcgtgcggga ccgcgccgtg
     6361 gccgcggccg ggttcgccac ccccaaccgc agcgcgttcc tcgccgactg cctcaccgac
     6421 ctcgacgccg cgctgcgcga gcgcggcggg cggctcgtgg tgcgctccgg cgacctggtg
     6481 gaggaggtgt gccgcgcggc gcgcgaggcg gacgccgacg aggtgcacct ggcggcggcg
     6541 cacagccgct tcgccacgcg gcgcgaggag cggctgcggc gggcgctgga gtccgacggg
     6601 cgccgcctgt ccgtgcacga cgcggtcacc gtggccgtac cgcccggcga ggtgaccccc
     6661 gcctcgtccg accacttcgc cgtcttcacg ccgtacctcc ggcgctggac gcaggtcccg
     6721 ctgcgcgcgg ccctcgacgc cccgcgccgc gtccccgtcc ccgaccacgt ccggggcgag
     6781 ccgctgcccg cccgtggttc cgtccccggc gtctcgcccg ccctggcgcc cggcggggag
     6841 agcgagggcc gcaggcggat gaccgcctac tggcgcaccg gactcgacgc ctacgacgac
     6901 acccgcgacg acctggccgc cgacgccacc tcgaagctct ccgcgcacct gcacttcggc
     6961 accctgtccg cggtggaact cgtccaccgg gcccgccgcc acggcggtcc cggcgccgag
     7021 gcgctggtcc ggcagctcgt ctggcgcgac ttccaccgcc aggtcctggc cgcccgcccc
     7081 gacgctgcgc acaccgacta ccgcacccgg cacgaccgct ggcgcaccga gagcaccgcg
     7141 cgggacgaca tcgaggcgtg gcaggagggc cgcaccggct atccggtgat cgacgcggcg
     7201 atgcggcagc tgcgccacga gggctggatg cacaaccggg cccggctgct gaccgcgagc
     7261 ttcctgacca agacgctcta cgtcgactgg cggatcggcg ccgcgcactt cctgtactgg
     7321 ctggtcgacg gggacgtggc caacaaccag ctgaactggc agtgggtggc cggcaccggc
     7381 accgacaccc gccccaaccg ggtcctcaac ccggtcacgc aggcgaagaa gtacgacccc
     7441 ggtggcgcct acgtgcgtcg ctgggtgccc gaactgcggg gcgtggagtg ccccgcggtc
     7501 cacgagccct ggaagctgcc cggccccgac cgggccgcgc tggactaccc cgacccggtg
     7561 gtggggctgg ccgagggcct ggagcgcttc cgccgggccc gcgcccgtcc gcagtgacct
     7621 cgtgtccgcc ggccgtcgtc aaccgcggcg ggtcgcgcgc gccgcccgcc gcagggcggc
     7681 ccagcggcca ccgccgggca ccgtccacag cgggtgcccg cgcagacccc agcgctccag
     7741 caacgtgttg gcggcgagga agccgctggt ggcggcgcgc tccatcaggg ccaccggcag
     7801 atccgtgcgc accgtgtcgc ccgcgacgac cagacccggc acgggcgtgc gcacggtggg
     7861 ccggtcaccg tgtccgccga ccgggaacag cgggcagtcg gcccgccact cgtggcgggc
     7921 gtccaccacg cgggcccggc cggtctccgg gtagaggcgg tgcagcgcgg cgagcagctc
     7981 cttctgccac cgctcccggt cggtgtcgcc gggcagggcg taggcgtgca gttccaccac
     8041 cgagccgccg gtgcgggcgg cccagcgggc ggcctcgccc tcccagcggt ccaggacgct
     8101 gacgttgtcc agcgggccgt agccgctggt gcccaggaag ccgggccggt cgccgcgcac
     8161 cggccggtcc agccacagcc gggagaccag gaacggcggc gcggtgcgca gccgcgcgat
     8221 ccgctcgcgc cacggctcgt ccccgaggtc cgcggaccgg gcgaccaggg cgcgcagggc
     8281 gcccgggtcc gcggccagca ccacggcgtc gcagtgctcc tccccgccgc cggcggccac
     8341 ggcgaagccg cccccgggca gggccgtcac cgactcgacg gcggtcgccg tgcgcaggag
     8401 cgccccgcgg cgggccagat acccggcgag cggatcccac agtgcctgcg ggaacggctc
     8461 ggtgggcacg tcgaacagca ggccctcggc cgatccgagg aagtagatgt ggaacatcag
     8521 cgccatctcc gccgccgaca gcacgcgcgg gtcggcgaag aagctgcggg agaagacctc
     8581 gaaggcgaga tgccgtgccg cggccgggaa acggatctcc tccaggaggt cgtgggcgct
     8641 ggtcgcgtcc agccggtcgt acacctccgg tacccgcacg tcgagcagcc cgagcgcggc
     8701 ccggacgttg atccgggcca ggtcgcgcac ccggaaggag gggctgagcg cgacgaaccc
     8761 gagcgcgccg agcggcgggg tgcgcgggac gtgccggaag ccgtcgcggg cgccgtccgc
     8821 gtgccgcagg gggtagtcgg gcaggccggt gaggcgggac agggccggat cggtgcggcg
     8881 cagcagggca cgcaggttgt agtactggcg gaagaaggcg tggaagccgc ggctcatcgt
     8941 gaccgtgctc ccgtcggcca gccgcgtggg ccgcccggcc agccggcccc cgagtgtctc
     9001 ctcgcgctcg tacagggtga cccgcacccc gcgctcggcc agcgcggtcg ccgcggacag
     9061 cccggcgatg ccgccgccga cgaccgctgc gcgcggggcc gaggcggggt ccgcccgcag
     9121 cgccccgggc ggtgcgggca gcagccgggc cagccggtcg cggcccgggc ggggcagggg
     9181 ccgcccggcg cggcgggtca ccgggggcct tccgcatcga cgccgccgca ccctgcctcg
     9241 tccggccggc gggccaccac ggtgtacgtg atgccggtct gccagccggg cagcggcagc
     9301 acccgcaccc gctcgaaacc ggcccgttcg acccgtcggc ccagggcgcc ggcggtgtcg
     9361 aaggcgacga cactgtgcca caggtggcgg tagagcggcc cgtcgccgag cagggtggcg
     9421 accggcagga gcagtccgcc gcacaccgcg gtccacaccg cccggtgcac ggcccggccg
     9481 ctcagcgcgt actcgtgcac cgcgaggcgg ccgtgcggtg cgagcagccg gcgggcggtg
     9541 gcgagtacgg cgtccgggtc ggcggtgttg cgcagcaggt acgcggcgaa gaccgcgtcg
     9601 aacgggccct gcaccccggc ctcggccagc cgctccaccg gcgcgtggac gaagcgcacc
     9661 ggccggggcc ggcgccgcgc ggcggcccgc cggagcatgc ccgcggaggc gtcgacggcg
     9721 gtgatgtccg cgccgggcag tacggcggcc agcgcggccg tggacgctcc ggtgccgcag
     9781 cccaggtcga gcacccgcag cccgctcccg tccggcggca gaccgagccg ccggaccgag
     9841 cggcgcagct gggcgtggta tccggggttg gcggccacca gggtgtcgta gctgcgggcg
     9901 gcgtggtcga aggcgccggc cagttcggcg tcgcgcagga gcgggggccg ggtccggggt
     9961 gtgcggggtg acgggggcat acgggtcgtg gctccggggg tcaggcggcg ggagaggtcc
    10021 ggcgcgggac gaagggcagg gtcagggccg aggcgagcat gggggcgacc ggcacgtgcg
    10081 cgccgatgcc caggtcctcc gccaggccgg tgcggccgtc caggaagcgc agcagccgcg
    10141 gtgcgggcac gcgcgtgaac aggcgggtga agaaggccgg tccgtccacc cggccgcggt
    10201 cgagtgcgtg cagcaggacg gcgtccatga gacgggcgcg ggcggagtgg gggcggggcg
    10261 ggagcggccg ccgcccgctg tgcagggcgg cggcgaccgc ggccgtctgc cgctgcacgg
    10321 cgctgaaggt gtagcccgtc gaggggcggg tcgcgccggc gcacgccccg atccggtaca
    10381 cgtccggcgc ggcccgccgg gggaagcccg cgtcggtcat cgggatcacg ccctgctcgc
    10441 acccggtcac ctcgtacccc tccaggccca gcacgcgccc cgcgtagtcg cgcagcgccc
    10501 ggtcgtaccc ggcacggtcg agcagccggc cggagaactc cgtgtactcc acgagcgcct
    10561 cgcacgggcc gacgggcagc acgtagccga aggacagccc gtgcgccggc tgcggcgtgc
    10621 ggaagtccat cagctccacg acggacggat cgaagaccgg tcgcgcggta cggacgaacc
    10681 agccgcggaa gtgctggaac agcgtcgtac gggcgggtgg caggcggggc agcgggcggg
    10741 agtcgaacac ccggcgggcg cgtacggcga ccctggtgcc gtccgcgcgc cgcgcgtgca
    10801 ccagggcgcc gccgccgggc gccggggtga tccggccgac ggccgcgtcg acccgggcca
    10861 cccgtccgcc gctcgccgcc atcgcccggc cggccagttc ctcgaaggcg tcggagcgca
    10921 gcatcttgta gtgcagcggg gcgatgccgg cggtcacggc cgcgccgtcg gcgccgtgga
    10981 cgcgcagccg ctgccaggag gcggtcaggg cctcgtcgta ggggccgccg tccggttccc
    11041 agaagcacca ggtgcgcggt gcggcccgcc ccgggccggg cggggcggcc agcagcaccg
    11101 tgtccagccg ccgggcgtgc gccggcggac gggccaggcg cagcgcgagc gacagccccg
    11161 ccgcgccggc ccccacgacg gccacatcgg cttccagctc cacgtccctc gctcctctcc
    11221 cgcccgccgc gtccggcggc cgtcgcgtcc cccgcgcggc ccgcgtcccg tggtgtgacg
    11281 tgcgtccggc cgaccggacc gtacggatgc ggcacccggc gtgtcgcgtg tcacccgcct
    11341 cggagcgcac cgcatcaccc gaacggcgca gccgcttcgg cgccccgcgc ggaagggaca
    11401 caggcaggcg atgtcacgac cggcgagagg aaccgcgatg cgctgcaccc aggacaccca
    11461 ccgggacccg gagccacccg gcgcccgccc acggcacgct cgcggccacc accgggcagc
    11521 aggccgcggc ccgtccggcg cgtgtgcgtt gtccgctggg gtcaccgggg tgttcggcgc
    11581 gtgtgtgtcg cccgccgggg tcaccggcct gtccggcgcc tgtgtgccgc ccaccggggt
    11641 caccggcgcg ttcgggcagc tccccggacc ggccgggggg atgccgggcg ccgccgcgca
    11701 cggctacgga ggcgtccggt gagcagagcg gtgaaggggc ccaccgatca tgtcgtggtc
    11761 gtcggtgccg gcctggccgg cctgtccgcc gcactgcacc tgctcggcgc gggccgccgg
    11821 gtgaccgtcg tggaacgcga cgccgggccc ggcggacgcg ccggccggat cgagcggggc
    11881 ggctacctga tcgacaccgg ccccaccgtg ctgaccatgc cggagatcgc cgacgaggcg
    11941 ttcgcggcgg tcggcgcctc gctgtacgac cacgtcgagc tgatcccgct gcatccggcc
    12001 taccgcgccc gcttcgccga cggcagcagt ctcgacgtgc acaccgacgc cgacgcgatg
    12061 gaggcggagg tggagcgctt cgccggcccc ggtgaggccg ccggctacca gcacctgcgg
    12121 cactggctga gcgagctgta ccgcgcagaa cggcaccggt tcctcgacgc cgacttcgac
    12181 tcggcgcggc aactgctcgg gcccggcctg ctccggctgg ccctgctcgg cggcttcggc
    12241 cgctgggagg ccgccgtcgc ccggcacctg cgcgacgaac ggctgcgccg cgtcttcacc
    12301 ttccaggccc tgtacgcggg ggtgcccccg gcgcgcgccc tggccgccta cgcggtcatc
    12361 gcctacatgg acaccgtcgc cggcgtctgc ttcccgcggg gcggcatgca cgccctgccg
    12421 cgcgcgatgg ccgaggcggc cgcggaggcc ggagccgtct tccactacgg acacgcggtc
    12481 acccggctgg aacgctccgg cgaccgcgtc accgccgtga tcgccggtca ccagcgcatc
    12541 ccgtgcgacg cggtcgtcct cacccccgac ctgcccgtca cctaccgcct gctgggccgc
    12601 accccgcgcc gtccgctgcg gctgcggcac gccccgtcgg cggtggtcct gcacgccggc
    12661 tgcgaccgta cgtggcccga actggcccac cacacgctgt ccttcggccg cgcctggcgg
    12721 cgaaccttcg acgaactcac ccgtaccggc gacctgatga gcgacccctc gctgctgatc
    12781 agccggccca ccgcgaccga ccccgcgctg gccccgcccg gccgccatct gcactacgtc
    12841 ctcgcgccct gccccaactc cgccatcggg ccccgcgccg ccgactggac ggacctcggc
    12901 ccgcgctacc gcgacagcgt cctgcgcacc ctggaccgcc ggggcctggc cggtatcgcc
    12961 gccgcgatcg aggaggagtg cctggtgacg ccggcggact gggccgcgca ggggcacgcg
    13021 gccggtacgc cgttctccgc ggcgcacacc ttcgcccaga ccggcccgtt ccgcccccgc
    13081 aacctggtgc gcggcacggc caacgccgtc ctcgccggct gcggcaccac gcccggcgtg
    13141 ggcgtgccgc ccgtgctgct gtcgggcaga ctcgccgccg cccgcctcac cggcaccgcc
    13201 cgcaccacca ccccgcgacc cgccgggaca ccggcccgcc cggcaggagc ccgcgcatga
    13261 cccggagcgc cggggtgccg gcccgcgcgg caggagccgg gcgtacggca tggagcgccg
    13321 gcccgcccgg caggagcccg cgcatgacct ggagcaccgg ggtgccggcc cgcgcggcag
    13381 gagccgggcg tacggcatgg agcgccggga cgcccggcag gagcccgcgc acgacccgca
    13441 gcgccggggt gccggcccgt ccgaggggag cgggcgtatg acccgcaggg ccggggcgca
    13501 ggcccgtgtg caggaggtgt ggtcgtgacg gcgcgggagc tggacgccgc cggtgtcgcc
    13561 ggtgcggaac tgcgggccgc ctacacccgc tgccgcgagc tgaacgcccg gcacggccgc
    13621 acgtacttcc tcgccacccg gctgctcacc cccggccggc gccccgccgt gcacgccctg
    13681 tacggcttcg cacgctgggc cgacgacatc gtcgactccc tcgacagcac cgccggcccg
    13741 cacgcccgcg cccgcgcgct cgaccggctg gacgccgatc tcgcccgcgg cctggccggt
    13801 ggcacgggag ccgagccggt ggtgcgggcg ctcgccgaca ccgcccgccg ctacgccatc
    13861 gaccaccacc acttcgccga cttcctcgcc gccatgcgca gcgacctgac gaccgtctcc
    13921 tacgccacct acaccgacct gcgccgctac atgcacggct ccgccgcggt gatcggcctg
    13981 cagatactgc ccgtactcgg cacggtggcg ccccgccggc aggcggagcc ctacgccgcc
    14041 gaactgggcg tcgccttcca gctcaccaac ttcctgcggg acgtgggaga ggacctcgac
    14101 cgcggacgcg tttacctccc cgaggacctc ctcgccgccc acggcgtcga ccgcgccctg
    14161 ctccgccact gccgggccac cggccgttcc gaaccccacg tcgtgcgcgc gctgcgggag
    14221 ttcgcgtcgc tcacccgcgc cgcctaccgg cgcgccgccc ccggcatcga cctgctcgac
    14281 ccggtctccc ggccctgcat ccgcaccgcg ttcgtcctgt acggcggcat cctggacgcc
    14341 gtcgcgggca ccggttacgc ggtactgcac cgccgtgccg cggtgccccg gcggcgccgg
    14401 gcactggtcg ccgcggacgg cctggtgcgg gtgaccgcgg cccgcaccgc cgcacgcctg
    14461 gccgggcgcc gggccgtgcc gcccgccgta cctccggccc cccgcaccgc cgcccgctcc
    14521 ccacgcggcc acgaggaggt cacgtgagcc ccgccccgcc gtcccgtccc cggcggctgc
    14581 cgctaggcct gcgccgcgcc cccgtcgcct gggaacgcca gcgccccacc tggcgcgagg
    14641 cccggcccgc gctgatcgcc gaggcgctcg aacgggccct ggcccgtccc gccggcaact
    14701 ggtacgtcgt cggcgcctcc cgcggcctgc gccccggccg gccgctcgcc cgcacggtcg
    14761 ccgggcggga gatcgtgctg tggcggaacg gagagggacg cccggtggcc gggccgggaa
    14821 gctgcccgca cctgggcgcc ccgctcgggg acggcgcggt gcgctgcggc accctggtgt
    14881 gccgctggca cggactcgct ctggacggcg ggccgttcgc gggctgggag ccgtacccgg
    14941 cccacgacga cggggtgttg ctctgggtac ggctggacaa ggccggtgcg gacccaccca
    15001 ccggccgccc gccggtgccg gagcgccccg cggtggccgg ggcactgacg gccgtgtaca
    15061 ccggggtggg ccggtgcgag cccgacgacg tggtcgccaa ccgcctcgac ccctggcacg
    15121 gggcgtggtt ccacccgcac tccttcgccg acctcaccgt ggtcggggtg cccggaccgg
    15181 acggggacgg cgacgcgttc acggtggacg tgtcgttccg ggtcaccggg cggctggtcg
    15241 tcccggtgcg cgcggtgttc accgcaccgg ggccgcgcac ggtggtgatg cggatcgtgc
    15301 ggggcgaggg ggaggggtcc gtcgtggaga cccatgccac cccgctcggc ccggacgtgc
    15361 tgggccggcc gcgcacggcg gtcgtggagg ccgtcgtcgc cacctccggc cggccggggt
    15421 tcaccgccgt ccgccacgcc gcccccctgc tgcgcccctt ggtccgggcc gccgccgccc
    15481 gcctgtggcg cgacgatctg gcctacgccg agcgccgctg gacgctccgc tcgtccgggc
    15541 gtctccccgg ctgagcgcgg ggcgggcgtc cggcgggcag cggctgtcgt aggcgtttca
    15601 tctggctgtc atagacgcgt cacggagagc gagttagagt tgcccaaaga tcacgcactg
    15661 tggccacacc ggcagtccgt gacgcaccgg caacaccatt gccacggggg aaggggaaag
    15721 gcgtgcacgt cacgcatgcg ctcgtcgcac cgagggaaag ccgctccgga ccgtcggcgg
    15781 cgtcggtccg cgaggagtcg gacgaccact tagcgctcat cgaggccctg tcgccagggc
    15841 gagcgaactc ccgtccggcc gaccggagtc ggcggcaacc acaccgcgta gagcggtgtc
    15901 ctgaccagta cggcggattc cctccgacgc gccggcgact cgccgcatcc ggggacgagc
    15961 cctgcgccgc cgcccggccc gccccgtgtc cgcgagcccg ggcacgcctt ccactctgcc
    16021 gcaccggaca actcatcgac agaccaggca cgttgcacgg ctgagaccgc gctctcccga
    16081 cgtccggacg gacggggtgg gcagcacccc gtcggcgcgc cgcggctccc gtccgtgcga
    16141 tctcccacgc cggtcccgcc ccgcgtcggc ctgcccgtgc tcctgccgcg cccggggcgt
    16201 cgtcgtcatg ccgtcggcac cgcaccgcag cactcgtacc acctccgtca cgttcaacct
    16261 gtttccgaag gtgctcgatg atctttcgca atgcgtacga cctggtcctc gacgaccttt
    16321 tcctcgacct gagcggtttc gtccccggcg tcgatctcac gctcaagatc gagggactca
    16381 acctcgccgg gtccatcaaa ctgaaggcgg ccgtgggcct cctggaggac ctggagcgcc
    16441 gtggcctgct caagcccggc ggccgggtca tcgagtcgtc atccggcaac ctcggcatcg
    16501 cgctcagctc ggtctgcgcg gcccgcggct accggttcac ctgtgtcgcg gaccccaaca
    16561 ccgcgaccac gagcgtccgt ctgatgcggg cgtacggcgc cgatgtcgtc atcgtcgacc
    16621 ggcgggacgc caacggcggc ttcctccagt cccgtatcga ccacatccac gcccggctgc
    16681 gcgaggaccc cggcctggtg tggcccaacc agtacgccaa caaggccaat ccgcaggcgc
    16741 attaccggcg caccgccccg gccctgctca aggagcgcga ggtcgacgtc ctcttcgtcg
    16801 gcgcgggcac caccggcacc ctcaggggat gcgccgagta cttccgcgag cactcgcccg
    16861 gcacccgcat cgtcgccgtc gacacggccg gctcggtcac cttcggctcc tccccggccc
    16921 gccggcacat ccccggcctg ggcacgagcc ggcgcccgga gatcttccgc gacggactcg
    16981 tggacgaggt cgtcatggtg ccggaggccg aggcggtgcg catgtgccgg cggctcgcga
    17041 ccgggcgggg cgtcctcgcc ggcggctcca ccgggtcggt gctcgccgcg gtcgagaccc
    17101 ggcaccgcga catccccgag ggcgcctcgg tggtcgccat cagcccggac ctcggcgagc
    17161 gctacctcga cacgatctac gacgacgact gggtcggcga gcgcttcggc gccgtcgacg
    17221 actgacccgg accccgtcgc cgtccccgca cgaccgcgca cctcgcacag aaatcgaagg
    17281 agtcaccatg ttcgaattcg atgtcgtcac cggccgaacc gtccgtgaca tcgtccggga
    17341 cagccgccgg gacatcgtcc gggtcgtacg cgacacctac ctggcccacc acgccgggcg
    17401 ttccgtgaac ccggacagct acttcctgcg cttccccgag aagccggcgg accggatcat
    17461 cgccctgccc gcctacctcg acggcgagcg cgaggtcgcc ggcatcaagt ggatcgcgag
    17521 cttcccggcc aacatcgagc gcggcatacc ccgcgcctcg gccacgctcg tcctgaacga
    17581 cgccgagacc ggctacccgt tcgcgctcct ggaggcctcg cagatcagcg ccgcacgcac
    17641 cgccgcgtcg gccgtcctgg cggcggacgt cctcaccggg gggcgcaagg gcggccggct
    17701 cgcggtggtg ggcgccggca tcatcgcccg caacatcctg gagttcttcc acgccgagca
    17761 gtggacgttc gagcaggtcg cggtgcacga cctgagccag gagtacggca cggccctggc
    17821 ggcccacgcc accgagcggc tggcgtaccc ggcgtcctac gccgagaccc tccagggggc
    17881 cgtgtccggc gccgacgtgg tcgtcttcgc gaccacggcc ggggagccgt acgtcctcga
    17941 acccggcgcc ttcgcccccg ggcagatcgt cctcaacatc tccctgcggg acatcggcgc
    18001 cgagatcatc gccggctcct acaacgtgct ggacgacgtc gaccactgcc tgaaggccaa
    18061 cacctccccg cacctggcgg aacagaagta cggcaaccgg gacttcgtca ccggcaccat
    18121 cgccgaggtg atcaacggcg aggtcacggt cggcacggac aagccggtcg tcttctcccc
    18181 cttcggcctg ggcgtcctgg acctcgccgt gggcctcgaa gtgcaccgcg tcgccgccga
    18241 gtcgggccgc gtcaccgcga tcgccgactt cttcggggag accgagcggt ggtgacgact
    18301 tccctccggc ggacgccggt cgcgggcacc gtcgggatca tcggcctggg ctcgcggggc
    18361 atcggcgtcc tcgaacgcct cgtcacccgc gccgcgcggc cggactgggc gggccgccgg
    18421 ctcgtggtcg aggtggtgga cccggacggc accggcgtcg gcatccacac cgtggaccag
    18481 cccgaccacc tgctgctcaa cacgatctgc acgcaggtga gcctcttccc cgaggaggcg
    18541 acggtgggcg cggccgtcgg cgaccggggt cccgacctgt acacctgggt gacggaccgg
    18601 ggcctgaagg tggccgacga cggtcacacc ctcggcgacg agggccggcc ggtacggccg
    18661 gacgactacc tgccccggcg ggtgctcggc gagtacctgg cctggttcct gcggcgcctc
    18721 ctcgaccgcg tccccgagaa cgtggagata cggttccacc gcgccacggc gaccggcctg
    18781 tccgccggcc cggacgactc ccggcggatc accctcgaca ccggcgagac cctgccggtg
    18841 gactcggtct tcctcaccac cggccacacc ccgccggccg cccccgaccc cgaggcaccg
    18901 ggagcgtccc gccgtatcca cgagatctac ccgcccgccg cggccttcgc ggccgtcacc
    18961 gccggccgga ccctcgccct cggcggcacc ggcctgtcgg ccatggacgt cctcgcctcg
    19021 ctcaccctgg gccggggcgg ccggtacgag gcggccgacg gcggcctgcg ctacctgccc
    19081 agcggacggg aaccgcgtgt cctgctgttc tcccggaccg gcatcccctt ccgggcccgg
    19141 cccgccgcca accgcactgg cggaccgtac cggccggtgg tgttcacccc cgaggccctc
    19201 gaccggctcc gctccaccgg ggacgaccgc cccctgagcc tgcgcggcga cctgcttccg
    19261 ctgctgcgca ccgagatgcg catcgccttc caccgccacg gcgccgccct cgcccggggc
    19321 accgaagccg agggcgccct gacggcgaag ctccgggcgg cggcggacgc gggcaccctg
    19381 gacgacgaac tgcgcgccct cgacctggca cacgccgagc ggttcggcca cttcgacccg
    19441 caggatctgc tcttccccga cggcgccgag tccgactcca gcgacgccta ccagaagtgg
    19501 tacgaggagc ggttgcggtc ggacctcgtg gaggcccggc tcggcctcgg cggcagcccc
    19561 accaaggccg gcctggaagt cctgcgcgac ctgcgcgacg tcgtacgcca cgccgtcgac
    19621 ttcggcggcc tggacgagga ctcccacgac gagttctacg gctccttcac cgccaccctc
    19681 aaccgctcgg tgaccggccc gcagctcgac cgccacgagg agctgctcgc cctgctggag
    19741 gccgggatcg tcagcgtccc cttcgggccg gcaccgcgcg tcgagtggga cggcacggcg
    19801 tggcggatct cctccacccg gctcggcacc ggccacagcg cacgggccga ctggctggcg
    19861 tacgccacct cgggccagcc cgacgtcgag gcgaccggca gcccgctgct ggcggacctc
    19921 gtggccggcg ggcgtctgtg ccggcaccgc cccggcgccc gcagcagcct cggtgtcgac
    19981 atcacggcgg accagcatcc cgtcgccgcc gacggtcggc ccgaccggaa ggtccgcgtc
    20041 ctcggcccgc tctgcgaggg ggccaccttc tacaaccact acgtgccctc gcccggcggg
    20101 cgcaaccgcg cgctggcgga cgccgaccgg tgcgtcaccg ccgtactggc cgaactcgcc
    20161 gccgccaccg agcccgagac caccaggagc cctgagcagt gaccctcatc gtccccaccc
    20221 ggatcgacgc cgtcgaccag ctcaccgagg aaggcatcgc ggtcaccgtc gagccccgcg
    20281 gggcgggcgc cgcgatcccg gccgtcgaac tcgccatcct caacctgatg ccggacaaac
    20341 cggtcaccga gacccagctg ctgcgcctgc tgtccggcgc cgggctcccc gtccgcgtca
    20401 ccctcctgcg cccccgtgac cacgtctcca ggagcacccc cgagacgtac ctgaaggagc
    20461 actaccagac gcacgaggac gtcgccgacc gccgtttcga cgccctgatc gtgaccggcg
    20521 ccgccgtcga gctgctgccc ttcgagcagg tgacgtactg ggacgagctg cgcggcatca
    20581 tggactgggc gcaggagcac gtcacctcga cccagtacgt ctgctggggc gcccaggccg
    20641 cgctgtacca ccggtacggc ataccgaagc acgagctgcc cgccaagctg ttcggcaact
    20701 tcccgaacag gctcaccgac ccctcctccc cgctcctggc cgacttcgaa ccggtcgtgg
    20761 cggtgccgca gtcgcgccac accgagaacc tccgcgccga cttcgagaag accggggagc
    20821 tgcggatcct ggtggagtcg cccgagtccg gggtgcacat cgccgccggc cgggacggcc
    20881 gggagctgta cgtctccggg caccccgagt acgaccccga caccctgctg cggcagttcc
    20941 gccgcgacca ggccaagggc gcggacatcg cccttccggt caactacttc ccggacgacg
    21001 atccttcggc ggacccggtg gagaactggc aggatcacgg acggctcttc taccgcaact
    21061 ggctgcgtgg tctcacgcgc ggcggaatcc ccctggccga catcacggcc gagaagtcag
    21121 gagtgtaagc gtgtcggttc ttcagtcact ggtctcgttc gccctggtgt cggccctgtt
    21181 ggtgatcatg ccgggcgtgg acaccgccct ggtcatccgc aacaccgtcg cgcgcggccg
    21241 gctccacggg ttcatcaccg gcgtgggtgt gggcgtcggc gccgtcatct ggggcgcagc
    21301 gatcgcggtg ggcatcggcg cgctgctgga ggcctccgag acggcgtaca ccgtgttccg
    21361 gatcgtcggc gccgcctaca tggtctggct gggcatcggg ctgtggcgct cggcccgggc
    21421 catcggcgcg gggcaggaga aggacaccga gctggaaccg gagtccgcct cgctgtggcg
    21481 ctccttcggc cgcggcatgc tcaacaacct ggccaacccc aaggtcggtg tcttctacgg
    21541 cgccacgatc ccgcagttca tcccgtccgg cgcgtccccc gcgttcatgg gcaccgcgct
    21601 ggccgccgtc aacgcggtgg aggcgatcat ctggtacggc ctgatcagcc tcggcgccca
    21661 cggcctgcgc acctggatga agcgccgcac ggtccgccgc aacgtcgacg ccaccgcggg
    21721 cacggtcatg atcgccttcg gcatcgtgat ggcggtcgag agctgagccg cggcaccggg
    21781 gtggcccgcc cgtatccggc caccccgggt gcacgtcacc cccgcacagc ccagcagctt
    21841 cccacacccg ctgggcagaa attcgatgac ctgccgtgtc gtcccggtcg ccgaccgcct
    21901 gccgccggcc gccctcgccc tcctcgtccg caccgccgcc accgtggacg ccgaggtcct
    21961 cgccagcacc cggaaggccc aggaacgcgc ggcgacggac gtcgtacgcg cgctcctgca
    22021 ggcctctccg gcgaaaccgc cccggagccc tcaacgcccc ccgctcagcc cgcgggtgac
    22081 ggcggcgtgc ggccctcgaa cgccgccagg atgcgttccg ccgccagcgt cgccgtcaaa
    22141 cggccctccc tgacctgccg ttcgaggtca ggggcggtcg cgcggaccgc ggggtcggag
    22201 tgcaggcggc cgaggagttc gtcgcgcacc atcgcccacg tccagccgac ctgctggtcc
    22261 cggcgcttgg cggccagccg gccggtggag tcgagcaggg tgcggtgctg ctccaggcgc
    22321 tcccagacgg tgtcgaggcc ggtcgactcg cgggcgctgc agtgcagcac cggcggggtc
    22381 cagaaggcgt ccttgccgtg catcaggcgc agtgcgcccg ccagttcccg ggcggcggcc
    22441 cgggcgtcgc gctcgtgcgg gccgtccgcc ttgttgacgg cgatcacgtc ggccagctcc
    22501 aggacgccct tcttgatgcc ctgcaactgg tcgccggtgc gggccagggt gagcaggagg
    22561 aaggagtcga ccatctccgc gaccgtcgtc tcggactggc cgacgccgac ggtctccacg
    22621 aggatcacgt cgtagcccgc cgcctccatc accaccatcg actcccgggt ggccttggcg
    22681 acgccgccca gcgtgcccgc gctgggggag gggcggacga aggcgtccgg gtcgaccgcc
    22741 aggcgctcca tccgggtctt gtcgcccagg atggagccgc ccgtgcgggt ggacgagggg
    22801 tcgacggcga ggaccgccac ccggtggccc agcgaggtca gcatcgtgcc gaacgcgtcg
    22861 atgaacgtcg acttgccgac accgggcacc ccgctcacac cgatccgccg cgcccggccg
    22921 ctgtgcggca gcagctcggt gagcaactgc tgggccagcg cccggtgctg tggccgggtg
    22981 gactccacga gcgtgatggc gcgggccacc agggcccgct tcccgtcgag cacacccttc
    23041 acataggtgt cgagatcgat cgcagccatg cgggggctac aggtcgtggc cgaggtcggc
    23101 cgacagtcgc tgcaccaggt cgtacgcggc gtccgggatc accgtcccgg gcaggaacac
    23161 ctccgccgcg cccatctccc gcagcgtcgg cacgtcctgc ggcgggatga cccccccgac
    23221 cacgatcatg atgtcctcgc ggccctcctc ggcgagcttc tcgcgcagcg ccgggacgag
    23281 cgtgaggtga cccgcggcca gcgaggacac gccgaccacg tgcacgtccg cctcgaccgc
    23341 ctgccgggcg acctcctccg gcgtctggaa cagcgggccg acgtcgacgt cgaaaccgag
    23401 gtccgcgaaa ccggtggcga tcaccttctg gccgcggtcg tggccgtcct ggcccatctt
    23461 ggcgaccagg atccgcggcc ggcgcccctc ggcctcctcg aacgcgtcca ccagggcccg
    23521 ggtgcggtcc accgacgggg actggcctgc ttcgttgcgg tacacgccgg aaatcgtacg
    23581 gatctggctc gcgtgccgcc cgtacacctt ctccagggcg tcggagatct caccgaccgt
    23641 cgccttggcg cgggccgcgt gcacggccag ctccagcagg ttgccgtcgc cgtcggcggc
    23701 ccgggtgagc gcgtccaggg cgtcccggca cgcggtctcg tcccgctcct cccgcagccg
    23761 gcgcagcttc tcgatctgct gggaccgcac ggaggagttg tcgaccttga ggacctcgat
    23821 cgcctcgtcg ttctccaccc ggtacttgtt cacgccgatc accggctggc gccccgagtc
    23881 gatgcgggcc tgggtgcggg ccgccgcctc ctccacgcgc agcttgggga tgccggcgtc
    23941 gatggcctgg gccatgccgc ccgcctgctc gacctcctgg atgtgcgccc aggccttgcg
    24001 ggcgaggtcg tacgtcagcc gctccacgta cgcgctgccg ccccacgggt cgatgacccg
    24061 ggtggtgccc gactcctgct ggatgagcag ctgggtgttg cgggcgatgc gcgccgagaa
    24121 gtccgtcggc agcgcgagcg cctcgtcgag ggcgttggtg tgcagcgact gggtgtggcc
    24181 ctgggtcgcc gccatcgcct ccacgcaggt gcgggtgacg ttgttgaaga cgtcctgcgc
    24241 ggtcagcgac cagcccgagg tctgcgaatg ggtgcgcagc gacagcgact tggtgttctt
    24301 cgggtcgaac tgcttcacca gcttcgccca cagcagccgc gccgcgcgca gcttggcgac
    24361 ctccatgaag aagttcatgc cgatcgccca gaagaaggag agacggggcg cgaacgcgtc
    24421 cacgtccagg cccgcctccc gtccggcccg gatgtactcc acgccgtccg cgagcgtgta
    24481 cgccagctcc aggtcggccg tcgcgcccgc ctcctggatg tggtagccgg agatggagat
    24541 ggagttg
//
