LOCUS       NZ_CP071839            21086 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 5725813
            Orig. end                         :: 5746899
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21086
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="17"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..21086
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21086
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:11086](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11086
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    693..708
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.35"
                     /tool="antismash"
     misc_feature    complement(982..991)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.16"
                     /tool="antismash"
     gene            1465..2202
                     /locus_tag="S1361_RS25890"
                     /old_locus_tag="S1361_25850"
     CDS             1465..2202
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS25890"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_25850"
                     /product="hypothetical protein"
                     /protein_id="WP_208034158.1"
                     /transl_table=11
                     /translation="MTSLDITDPVLEPVTLDLAQRVTLGSRRQPPDEQPGRIALGRPVC
                     LPLDLATVDEEARIFLSGRPDSAFWLLALVCSFRAVEDEPMESAWLNVRLRTVRPAGAE
                     PPTAWSMEPLALADAVEVSKTVSLDAELKLTSVLVPIEVGPSAGREWTRSYERSETYVQ
                     AHAEGSAQPSWFFTRTPVREIDGVHRLRTVVELPATAVGEAEVSVGATLKLKRCGLIPY
                     RTDPDRVPAPRTVRLERPSAPTQ"
     gene            2413..3228
                     /locus_tag="S1361_RS25895"
                     /old_locus_tag="S1361_25855"
     CDS             2413..3228
                     /GO_function="GO:0003697 - single-stranded DNA binding
                     [Evidence IEA]"
                     /GO_function="GO:0008233 - peptidase activity [Evidence
                     IEA]"
                     /GO_process="GO:0009432 - SOS response [Evidence IEA]"
                     /GO_process="GO:0018142 - obsolete protein-DNA covalent
                     cross-linking [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019980380.1"
                     /locus_tag="S1361_RS25895"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25855"
                     /product="SOS response-associated peptidase"
                     /protein_id="WP_208034159.1"
                     /transl_table=11
                     /translation="MCGRYASSRRPEDLAGIFEVEKWEPEESLEPDYNVAPTKEVYAVL
                     DRPLKDADSSRPVRQLRRLKWGLVPSWAKTPEGGARMINARAETVHEKPAYRRAFAARR
                     CILPADGYYEWVTGSQERELEVEGRKKRPRKQPYFVLPADGSVFAMAGLYEFWRDRTLP
                     DDHPQAWWVTCSVITTEAEETPLAVAPAEGPRSLADIHPRMPLMLTPDRWDAWLDPART
                     DPDDLRGLLAPPPAGLMRAYPVPTAVSNVRNNGPELLKELEAPEEGTLF"
     gene            3230..3856
                     /locus_tag="S1361_RS25900"
                     /old_locus_tag="S1361_25860"
     CDS             3230..3856
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973757.1"
                     /locus_tag="S1361_RS25900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25860"
                     /product="alpha/beta family hydrolase"
                     /protein_id="WP_208034160.1"
                     /transl_table=11
                     /translation="MIEIVETDAGTARITWHKAKQARLVLAVSHGAGGGIEARDLQALA
                     RVLPEHGVTVALVEQPWRVAGKKVAPAPRTLDTGWRGVWPALSGMELPVISGGRSAGAR
                     VACRTAAELGAHAVLALSFPLHPPGRPEKSRAAELLGAGVPTLVVQGGNDPFGKPAEFP
                     EGGFALVEVPYGDHGFAVPKRAELTQERALEIITGGVREWIASLG"
     gene            4112..4807
                     /locus_tag="S1361_RS25905"
                     /old_locus_tag="S1361_25865"
     CDS             4112..4807
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0016987 - sigma factor activity [Evidence
                     IEA]"
                     /GO_process="GO:0006352 - DNA-templated transcription
                     initiation [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1032: RNA
                     polymerase, sigma-24 subunit, ECF subfamily"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973756.1"
                     /locus_tag="S1361_RS25905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25865"
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_208034161.1"
                     /transl_table=11
                     /translation="MGPVTGTDAGTDNGQAELPEGQGASTDASDETTVERSARFERDAL
                     EFLDQMYSAALRMTRNPADAEDLVQETYAKAYASFHQFREGTNLKAWLYRILTNTFINS
                     YRKKQREPQRSAAEEIEDWQLARAESHMSTGLRSAESQALDHLPDSDVKEALQAIPEEF
                     RIAVYLADVEGFAYKEIADIMGTPIGTVMSRLHRGRRQLRGMLEDYARERGLVPAGAGE
                     SNEAKGSGS"
     gene            4804..5115
                     /gene="rsrA"
                     /locus_tag="S1361_RS25910"
                     /old_locus_tag="S1361_25870"
     CDS             4804..5115
                     /GO_function="GO:0016989 - sigma factor antagonist activity
                     [Evidence IEA]"
                     /GO_process="GO:0045454 - cell redox homeostasis [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="rsrA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136687.1"
                     /locus_tag="S1361_RS25910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25870"
                     /product="mycothiol system anti-sigma-R factor"
                     /protein_id="WP_208034162.1"
                     /transl_table=11
                     /translation="MSCGEPHETDCSEVLDHLYEFLDSEMPDVDRDKFQHHFEECSPCL
                     EKYGLEQAVKKLVKRCCGHDDVPADLRAKVMGRIELIRSGQTVSERDVTKAPAAPQES"
     gene            5270..6574
                     /locus_tag="S1361_RS25915"
                     /old_locus_tag="S1361_25875"
     CDS             5270..6574
                     /EC_number="3.1.4.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674892.1"
                     /locus_tag="S1361_RS25915"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25875"
                     /product="HD-GYP domain-containing protein"
                     /protein_id="WP_208034163.1"
                     /transl_table=11
                     /translation="MDAVPARARGYVAAVALLTVLCLLPLPAGHTPWGALGLLAALCAV
                     CEHAVRRRFGGTFYPVLLAGAFLLPPAAAALVPVPAGLLSPVAHRPALPRRVWRAAQPA
                     LAVWAASRVHGTLGGRDAVAGSDFPHALLPAGAAVLAFCLVLTVLDGGLRAAVGLVPPR
                     RAWRGLLARSLAPVAVHGLAGLMMAVLWRSPYGPVAALLVLLPMCVSWWVFAQYHRERA
                     AHQATIRALVQAVDIKDGYTRGHSERVGHASVLIARELGMDDERVEVLRFAGILHDVGK
                     LGVPTRLLRKNGPLTPEERRIIELHPEYGHEMVRGISFLGEARAAILHHHERLDGSGYP
                     YGLAGDRIPECARIVAVADAFDAMTSTRCYSRARPVEAAVAELERCAGKHFDPRMVGAL
                     VRALARSGWHPAVTADEPAQDTPTAGRAADSGAPR"
     gene            6571..7854
                     /locus_tag="S1361_RS25920"
                     /old_locus_tag="S1361_25880"
     CDS             6571..7854
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674893.1"
                     /locus_tag="S1361_RS25920"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25880"
                     /product="metal-dependent phosphohydrolase"
                     /protein_id="WP_208034164.1"
                     /transl_table=11
                     /translation="MTALRLIHGAAALVAAGSLAVTLWTGLEDRGVALAFGMLITVGEL
                     TRWSDAQARRQAAPLGAAGSMAYALLGADAGRPGHHDAAQVITVVLVATLLGAVPHIWS
                     GGSPTVDHLARRLLTVGFAAVCFQPLYSQGVFVSWGGPAYALLLLTLLALTSLCGAVLA
                     AALAHSRTRWPFGPLLREELRGLLGIGSTVCATGAVMALAVAVVGLWALPVFCLPMLLV
                     QLSLRRYTAVRATYRQTIASLARATEIAGCTPAGHAHRVAALSQAVGRDLGLTGRELTV
                     LEYAALMHDIGQLSLVDPVPGGATAALPAAEQRRIALLGGAVVRQTGVDAAVAVVVERQ
                     ADPYPEQPLAARIVRAVNAYDEMTRDAGPDGPLRALEELRLGTAGDYAPEVVESLARVL
                     ARPPGGRERVSVRRTGLSDPVPGWVTHG"
     gene            7954..8934
                     /locus_tag="S1361_RS25925"
                     /old_locus_tag="S1361_25885"
     CDS             7954..8934
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019889310.1"
                     /locus_tag="S1361_RS25925"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25885"
                     /product="hypothetical protein"
                     /protein_id="WP_208034165.1"
                     /transl_table=11
                     /translation="MRIFGKGRHRPSASWRQATDRAFTLIGDGRYEDAGELLTRAADLE
                     PWMSESWFNLALLHKFRHDWEQARAAGLRAVALLDRETGAPDWWNVGIAATALQDWPLA
                     RRAWQAYGLKVPGASAAAAEPVGMELGSAAVRLSPEGEAEVVWGRRLDPARLEVLSIPL
                     PSSGRRWGEVVLHDGVPHGERTTSTGHSYPVFDEIELWAPSPVPTWVVLLEAATEADRD
                     ALEQLAADAGFAAEDWSSSVRLLCRMCSESRMPSDEGEGVHLDPHDHSEPGHPGPLGHR
                     TDGQLWVPERECGVAAPASLVRGLLDGWVADSPDSRDWRDLEEVC"
     gene            9059..9709
                     /gene="def"
                     /locus_tag="S1361_RS25930"
                     /old_locus_tag="S1361_25890"
     CDS             9059..9709
                     /EC_number="3.5.1.88"
                     /GO_function="GO:0042586 - peptide deformylase activity
                     [Evidence IEA]"
                     /GO_process="GO:0036211 - protein modification process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="def"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1275: peptide deformylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004983603.1"
                     /locus_tag="S1361_RS25930"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25890"
                     /product="peptide deformylase"
                     /protein_id="WP_208034166.1"
                     /transl_table=11
                     /translation="MAQQDTDQQHAGVLPVDDEGYVVDTEDCEERERAWRERGTSRPIT
                     VVGNPVLHKECRDVTEFGEELQQLVADMFASQRTAEGVGLAANQIGVDLKVFVYDCQDD
                     EGVRHVGVVCNPKLVDLPAERRRLDDSNEGCLSVPTAYASLPRPDYAEVTGQDEQGNPI
                     RVRGTGYFARCLQHETDHLYGYLYIDRLSKRDRKDALRQMAENEPRYPVVAND"
     gene            10001..11086
                     /gene="cyc1"
                     /locus_tag="S1361_RS25935"
                     /old_locus_tag="S1361_25895"
     CDS             10001..11086
                     /EC_number="4.2.3.37"
                     /GO_function="GO:0052680 - epi-isozizaene synthase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="cyc1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992851.1"
                     /locus_tag="S1361_RS25935"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25895"
                     /product="epi-isozizaene synthase"
                     /protein_id="WP_208036771.1"
                     /sec_met_domain="T1TS (E-value: 8.2e-65, bitscore: 218.7,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHAFPHSTTATATAVVVPPALALPVIESAFPRQLHPYWPRLQEKT
                     RRWLLEKRLMPPAKVQEYADGLCYTDLMAGYYTDASDDVLQAIADYSAWFFVWDDRHDR
                     DIVHGRAGDWRRLRYRLHAALDAPRHHLHHPDPLVAGFADSVLRLYGFLSRTWNQRFAR
                     HFHAVIEAYDREFRNRTRGHIPGVEEYLALRRLTFAHWIWTDLLEPSAGCELPEAVRNN
                     PAYRRAALLSQEFAAWYNDLCSLPKEIAGDEVHNLGISLITHAGLTLEEAVDEVRRRVE
                     ECISEFLEAERKVLQFARDLDDGTVRGKELSAAVRSCVGAMRNWFGSVYWFHHESGRYR
                     VDSWEDRSTPPYVTNETAGEK"
     gene            11083..12477
                     /locus_tag="S1361_RS25940"
                     /old_locus_tag="S1361_25900"
     CDS             11083..12477
                     /GO_function="GO:0004497 - monooxygenase activity [Evidence
                     IEA]"
                     /GO_function="GO:0005506 - iron ion binding [Evidence IEA]"
                     /GO_function="GO:0016705 - oxidoreductase activity, acting
                     on paired donors, with incorporation or reduction of
                     molecular oxygen [Evidence IEA]"
                     /GO_function="GO:0020037 - heme binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674897.1"
                     /locus_tag="S1361_RS25940"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25900"
                     /product="cytochrome P450"
                     /protein_id="WP_208034167.1"
                     /sec_met_domain="p450 (E-value: 1.2e-70, bitscore: 237.3,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVESVSPQSPQSPATPAAPSPELREPPLAGGAVPVLGHGLRLAR
                     DPLAFMSGLREHGDVVRLKLGPKTVYAVTTPALTGALALSPDFKIDGPLWESLEGLLGK
                     EGVATANGPRHRRQRRTIQPAFRLDALPGYGPVMEEEAHALTERWQPGSTVDCTSESFR
                     VAVRIAARCLLRGEYMDERAERLSTDLATVFRGMYRRMVIPLGPLYRLPFPANREFNRA
                     LADLHLLVDEIVAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSET
                     VASTIMWLLQVLAEHPEHAEKVRTEVESVTGGRPVGFEHVRSLTHTNNVVVEAMRLRPA
                     VWILTRRAVTDTVLGGYRIPAGADIVYSPYAIQRDGRSYARPLDFDPDRWLPERARDVP
                     KYAMSPFSVGNRKCPSDHFSMTQLSLITAAVSAKYRFEQAGGSDDTTRVGITLRPHDLL
                     LRAIPW"
     misc_feature    11473..11475
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(12497..13459)
                     /locus_tag="S1361_RS25945"
                     /old_locus_tag="S1361_25905"
     CDS             complement(12497..13459)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018544423.1"
                     /locus_tag="S1361_RS25945"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25905"
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_208034168.1"
                     /transl_table=11
                     /translation="MLKNVAAVLLNGVHPFELGVVCEVFGIDRSDEGLPVYDFAVVSAE
                     GPELGTHCGFTVSTPYGLERLEEADLIAVPAGEAYAEREYPPELLAALRRAVDRGTRVL
                     SVCSGVFLLAAAGLLDGRRCAVHWHHAEQLSRRYPRLTVEPDVLYVDEDPVITSAGTAA
                     GIDACLHLVRKEQGPEVANKIARRMVVPPHRDGGQAQFIERPLPKTPCDTVGEVLAWME
                     AHLDQEVTVEQLAARAHMAPRTFARRFQQETGTTPYRWILRQRVLLAQELLEGTDETMD
                     TIAWRTGFGTAAALRHQFLRALGTTPNAYRRAFRGPRAA"
     gene            13553..13762
                     /locus_tag="S1361_RS25950"
                     /old_locus_tag="S1361_25910"
     CDS             13553..13762
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674899.1"
                     /locus_tag="S1361_RS25950"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25910"
                     /product="hypothetical protein"
                     /protein_id="WP_243769298.1"
                     /transl_table=11
                     /translation="MNGNQIEGLIGMLATLGILVLLVLPSALGVLRDRRIDRQIRQARQ
                     PGAPNRPAQEPRRHGRRHGAARPA"
     gene            13759..14203
                     /locus_tag="S1361_RS25955"
                     /pseudo=""
     CDS             13759..14203
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018104307.1"
                     /locus_tag="S1361_RS25955"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MTQSALTLLTATGAHAEGRGDIRVVKTVVNKGGNVIVGTSKKVTF
                     PHSDDADSNRLAGVWQVNATVKANDGDYGISDRGPGCRADRHRQAVPGELGGPEVPEDR
                     AHGRRRKARHQGHRHLGGQPALVLPRHDDDRADRVGRGRGEAEV"
     gene            complement(14211..15224)
                     /locus_tag="S1361_RS25960"
                     /old_locus_tag="S1361_25920"
     CDS             complement(14211..15224)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0009263 - deoxyribonucleotide biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674901.1"
                     /locus_tag="S1361_RS25960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25920"
                     /product="ribonucleotide-diphosphate reductase subunit
                     beta"
                     /protein_id="WP_208034170.1"
                     /transl_table=11
                     /translation="MTSRNTNLLDPGFELTLRPMRYPDFYERYRDAIKNTWTVEEVDLH
                     SDVADLARLTPEEQHLIGRLVAFFATGDSIVANNLVLTLYKHINSPEARLYLSRQLFEE
                     AVHVQFYLTLLDTYLPDPDDRAAAFAAVENIPSIREKAEFCFKWINEVEKIDRLETKAD
                     RRRFLLNLICFAACIEGLFFYGAFAYVYWFRSRGLLHGLATGTNWVFRDETMHMSFAFD
                     VVDTVRKEEPELFDDQLGQEVTDMLKEAVEAELQFARDLCGDGLPGMNTDSMRQYLECV
                     ADQRLTRLGFAPVYGSENPFSFMELQGVQELTNFFERRPSAYQVAVEGTVDLDEDF"
     gene            complement(15224..17593)
                     /locus_tag="S1361_RS25965"
                     /old_locus_tag="S1361_25925"
     CDS             complement(15224..17593)
                     /EC_number="1.17.4.1"
                     /GO_component="GO:0005971 - ribonucleoside-diphosphate
                     reductase complex [Evidence IEA]"
                     /GO_function="GO:0004748 - ribonucleoside-diphosphate
                     reductase activity, thioredoxin disulfide as acceptor
                     [Evidence IEA]"
                     /GO_process="GO:0009265 - 2'-deoxyribonucleotide
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006378224.1"
                     /locus_tag="S1361_RS25965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25925"
                     /product="ribonucleoside-diphosphate reductase subunit
                     alpha"
                     /protein_id="WP_208034171.1"
                     /transl_table=11
                     /translation="MTIAPADPASVSELETDGPGTALLRTLTELTADLPDADPGRIAAA
                     ALRGRSARADEAELRELATEAAAGLISEDPAYSKLAARLLTLTIRDEAASQGVTSFTES
                     VAVGHREGLIADRTAEFARLHAERLDALVDASADDRFGYFGLRTLYSRYLLRHPITRKV
                     VETPQHFMLRVASGLAEDDTPRSVDEVAALYGLMSRLDYLPSSPTLFNSGTRHPQMSSC
                     YLLDSPLDELDSIYDRYHQVARLSKHAGGIGLSYSRIRSRGSLIRGTNGHSNGIVPFLK
                     TLDASVAAVNQGGRRKGAAAVYLETWHSDIEEFLELRDNTGEDARRTHNLNLAHWVPDE
                     FMRRVNADAQWSLFSPADVPELVDLWGEEFDAAYRKAEAAGLARKTLPARELYGRMMRT
                     LAQTGNGWMTFKDAANRTANQTAEPGNVIHSSNLCTEILEVTDDGETAVCNLGSINLGA
                     FVRDADIDWERLDRTVRTAVTFLDRVVDINFYPTEQAGRSNAKWRPVGLGAMGLQDVFF
                     KLRLPFDSAEAKALSTRIAERIMLAAYEASADLAERNGPLPAWEQTRAARGVLHPDHYE
                     VDLTWPERWDALRRRIAETGMRNSLLLAIAPTATIASIAGVYECIEPQVSNLFKRETLS
                     GEFLQVNSYLVQDLKDLGVWDARTREALREANGSVQDFLWIPQDVRELYRTAWEIPQRG
                     LIDMAAARTPFLDQAQSLNLFLETPTIGKLSSMYAYAWKSGLKTTYYLRSRPATRIARA
                     AQGQAQAAKPVPVQQIAEPDAVACSLENPESCEACQ"
     regulatory      complement(17720..17857)
                     /bound_moiety="adenosylcobalamin"
                     /db_xref="RFAM:RF00174"
                     /inference="COORDINATES: nucleotide
                     motif:Rfam:14.4:RF00174"
                     /inference="COORDINATES: profile:INFERNAL:1.1.5"
                     /note="cobalamin riboswitch; Derived by automated
                     computational analysis using gene prediction method:
                     cmsearch."
                     /regulatory_class="riboswitch"
     misc_feature    complement(17841..17855)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: medium, score: 23.4"
                     /tool="antismash"
     misc_feature    complement(17872..17886)
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: strong, score: 25.12"
                     /tool="antismash"
     gene            complement(18231..19859)
                     /locus_tag="S1361_RS25970"
                     /old_locus_tag="S1361_25930"
     CDS             complement(18231..19859)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674905.1"
                     /locus_tag="S1361_RS25970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25930"
                     /product="sodium:solute symporter family protein"
                     /protein_id="WP_208034172.1"
                     /transl_table=11
                     /translation="MKDGVNGVALGVFIFFFLAVTVMGFLAARWRRAENEHSLDEWGLG
                     GRSFGTWITWFLLGGDLYTAYTFVAVPAAIYAAGASGFFAVPYTILVYPLIFTFLPRLW
                     SVSHRHGYVTTSDFVRGRFGSKGLSLAVAVTGILATMPYIALQLVGIQAVLDVMGVGGG
                     ENTNWFVKDLPLLIAFGVLAAYTYSSGLRAPALIAFVKDTLIYIVIAVAIIYIPIKLGG
                     FDDVFAKAGHALGQVNPDTGKPRGALAPGEANQWTYATLALGSALALFMYPHSITATLS
                     SRSREVIRRNTTILPLYSLMLGLLALLGFMAIAAGVKVGNGQLAIPQLFEDMFPDWFAG
                     VAFAAIGIGALVPAAIMSIAAANLFTRNIYKDFIKPDATAQQETKVSKLVSLLVKVGAL
                     VFVLTMDKTVAINFQLLGGIWILQTFPALVGGLFTRWFHRWALLAGWAAGMIYGTAAAY
                     GIASPTQKHFGGNAKEIPGIGEIGYIGLTAFVLNVLVTVVLTVVLRAVKAPDGVDETRP
                     QDYTADAGDPGVQVELPPATAGSAH"
     gene            complement(19856..20119)
                     /locus_tag="S1361_RS25975"
                     /old_locus_tag="S1361_25935"
     CDS             complement(19856..20119)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004925869.1"
                     /locus_tag="S1361_RS25975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25935"
                     /product="DUF3311 domain-containing protein"
                     /protein_id="WP_208034178.1"
                     /transl_table=11
                     /translation="MSETPEVRPPVVTPGRVIIALCLVAPFVAMLWVGSYAKTDPAFIG
                     IPFFYWYQMLWVLISTALTMLAYKLWQRDQRARKGANGGAAK"
     misc_feature    complement(20190..20204)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.35"
                     /tool="antismash"
     gene            complement(20243..21004)
                     /locus_tag="S1361_RS25980"
                     /old_locus_tag="S1361_25940"
     CDS             complement(20243..21004)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003973740.1"
                     /locus_tag="S1361_RS25980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_25940"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_208034180.1"
                     /transl_table=11
                     /translation="MSTDVSSAENEVGTTRTARVPKYYRLKKHLLDMTETQAPGTPVPP
                     ERTLAAEFDTSRTTVRQALQELVVEGRLERIQGKGTFVAKPKVSQALQLTSYTEDMRAQ
                     GLEPTSQLLDIGYITADDRLAELLDIAPGGRVLRIERLRMANGEPMAIETTHLSAKRFP
                     ALRRSLAKYTSLYTALAEVYDVHLAEAEETIETSLATPREAGLLGTDVGLPMLMLSRHS
                     LDREGQPVEWVRSVYRGDRYKFVARLKRPAE"
ORIGIN
        1 cgaggtcgtt cagctgctgc tccaggtcat caaggggcgc cggttcgctg cgatgctggc
       61 ggagggaacc cgcgacttcc gcctggacga gcgcacccgc tcgctgctag gcctggcggc
      121 cgaggccgag gcggcgctgt ccgaggactc ggacatcctg cggccggagc cgttcgacgc
      181 ggcattgggg gacgacgacc tgctgacggc ctgggtggac gagtacgaga agggaccttc
      241 acagaccccc gaggaccggc tggccggact gcagcgcgcg gtcgaacggc ggctgtcggc
      301 cgctctgctg ccgacatcgg cgccgcacct ggtgccgctg gcggagatcc agcggcgcct
      361 cgactcccgg acagccctcc tgctgctgtt cgagggagcc ggggtcgacg gcaacgtcac
      421 catgggccag ttgctgatca ccagggattt cgagtacgcc gccatcggca cggagcagat
      481 gcccgcgggc accatccgca tgtccgaccg gggccggacc gtgacggtgc ccgcgagcgg
      541 ggtctacgtg ggcgcgctgc gccgggccat ccacatgtcc gatccgggtc ccttcgatgt
      601 gacaccgcag gccgcacagg atctcgcggg cgcggccgac cgctacgcac gcgcggtgaa
      661 caactgccgg gaccgtctga cggccgccgg agtggaccac ctggtcgtcg tcccgcacgg
      721 cgccggccgc tatgtccccg tccacctcgt cggccctccg ggacatccgc tcgccgacga
      781 ctggaccgtc acctatctgt ccaacctcgc ccaactcttc gccgatcccc ggcccgcacc
      841 gccacgggac ggcgtcggcg tgttcgcgct gtcctacacc gaccagcccg aactgccccg
      901 gctcgacgac tccgtggacg aggcccgcac catcgctgac gtctgcggta cgacggccct
      961 ggtggacgcg gcggccaccg aggccgcctt cacccgtgcc ctggagacac gcaggtacgt
     1021 ccacctgcgg gcacacggcc ggctgtacgt cgacgcgccg agcttccaca ccgtgttcct
     1081 gcatccggcg cgagggcccg aggggcacga cggacggttg cgggcctacg agatccttcc
     1141 cctcgacgtg accggcctgg agctggtcac gctgggagca tgcgagacgg cgctgggccg
     1201 ggtggaccag tacgacaacc cgcgaggcct gcccgcggcc ctgctgctgg ccggcgcgcg
     1261 cgcagtcgtc gggacgctgt ggcccgtcct cgcttcggcg agcacctact tcttcgccga
     1321 gctgtaccga ggtctcctgc acgacgacct cgatgtgccg acggcgttca gggcggcgca
     1381 gcgcgcgacg cgcacccggt tccccgcata ccgggactgg ggagccttct atctggtcgg
     1441 cggactgacg agggagtcaa cggcatgacg agcctggaca tcaccgatcc cgtgctggag
     1501 ccggtcaccc tcgacctcgc gcagcgggtg acgctcggat cgcggcggca gccgcccgac
     1561 gagcagcccg gacgcatcgc actgggcagg cccgtctgcc tgcccctcga cctggccacg
     1621 gtggacgaag aggcccggat cttcctctcg ggcagaccgg actccgcgtt ctggctgctg
     1681 gccctcgtct gcagcttccg ggccgtcgag gacgagccga tggagtcggc ctggctgaat
     1741 gtccggctcc gcaccgtgcg gcccgccgga gcggaaccac cgacggcgtg gtcgatggaa
     1801 ccgctggctc tggccgatgc ggtggaggtg agcaagaccg tcagcctgga cgccgaactg
     1861 aaattgacct ccgtgctggt cccgatcgag gtcggtccct cggcgggccg cgagtggacg
     1921 cgcagctacg agcggtcgga gacctatgtc caggcccatg ccgagggcag cgcccagccc
     1981 tcctggttct tcacccggac cccggtgcgg gagatcgacg gcgtgcaccg gctgcgcacg
     2041 gtcgtcgaac tgcccgcgac cgccgtgggg gaggccgagg tgtcggttgg cgcgacactc
     2101 aagctcaagc gctgcggcct gattccgtac cgcaccgatc cggaccgcgt gccggcgccc
     2161 cggacggtgc gtctggagcg gccgtccgcc cccacgcagt gaccccgcca tcgtgtacgt
     2221 gatccgttac ggctggtcgc catacggcct gtgacaaggg gtcgcttcga ccgtgctcgg
     2281 cacggtctgc cactcttgga cgcgtcccgg tggctgcgac acaagagctt caaggagacg
     2341 gcggacccgt acgggcactt cgcccgctgg ctggtgctcc agcgtttccg caggtcggag
     2401 gggtgatcac agatgtgcgg acggtatgca tcgagtcgta ggcccgagga tctcgccgga
     2461 atcttcgagg tcgagaagtg ggagcccgag gagagcctgg agcccgacta caacgtggcg
     2521 ccgaccaagg aggtctacgc cgtcctggac cgccccctga aagacgcgga ctcctcgcgt
     2581 ccggtccggc agctgcgcag gctgaagtgg gggctggtgc cgtcctgggc caagaccccc
     2641 gagggcggcg cccggatgat caacgcccgc gcggagacag tgcacgagaa gcccgcctac
     2701 cggcgcgcct tcgccgcccg ccgctgcatc ctgccggccg acggctacta cgagtgggtc
     2761 accggctcgc aggagcgcga gctggaggtg gagggcagga agaagcggcc ccgcaagcag
     2821 ccgtacttcg tgctgcccgc cgacggctcg gtgttcgcga tggccggcct gtacgagttc
     2881 tggcgcgacc gcaccctgcc cgacgaccac ccgcaggcct ggtgggtcac ctgctcggtg
     2941 atcaccaccg aggcggagga gaccccgctg gccgtcgccc ccgccgaggg cccgcgctcc
     3001 ctcgccgaca tccacccccg gatgccgctc atgctcaccc cggaccgctg ggacgcctgg
     3061 ctcgaccccg cccgcaccga ccccgacgac ctgcgcggac tgctcgcccc gccgcccgcc
     3121 ggcctgatgc gcgcctaccc ggtccccacc gccgtcagca acgtccgcaa caacggcccg
     3181 gagctgctga aggagctcga agcgccggaa gagggcacac tcttctagcg tgatcgagat
     3241 tgtcgagacc gacgccggga ccgcccgcat cacgtggcac aaggcgaagc aggcgcggct
     3301 ggtgctggcc gtgagccacg gtgcgggcgg tggcatcgag gcacgggacc tccaggcgct
     3361 cgcccgggtg ctcccggagc acggtgtgac cgtggccctc gtggaacagc cctggcgcgt
     3421 cgccgggaag aaggtggccc ccgcgccgag gaccctggac accgggtggc ggggcgtgtg
     3481 gcccgcgctg tccgggatgg agctgccggt gatctccggc ggccgcagcg cgggcgcccg
     3541 ggtcgcctgc cgcacggcgg ccgagctggg cgcgcacgcc gtgctcgccc tgagcttccc
     3601 gctgcacccg ccgggcaggc cggagaagtc gcgggccgcg gagctgctgg gcgccggggt
     3661 gcccacgctg gtcgtgcagg gcgggaacga ccccttcggg aagccggcgg agttcccgga
     3721 gggtggtttc gcactggtcg aggtgccgta cggcgatcac ggcttcgccg tgcccaagcg
     3781 cgccgagctc acccaggaac gggcgctgga gatcatcacc ggcggggttc gggagtggat
     3841 cgcgtcactc gggtgacccg ggaatgccgg gctccggcgc gctgttgacc ccgacagaag
     3901 tgctggaggc ctcggcaccg acgtcgtagg agaggaagtc cgccgcatgg gttcgaccat
     3961 ctgcccgagc catacgcgta gcgctgacct ggactggacg gtgctgcacg cggcgaagac
     4021 cgcgcctatt cgaggggcgg caggcacggg tcgtgttcta tcctccgaat cgagtgggac
     4081 cggtttcggt cccgcccggg atcttgagga ggtgggtccg gtcactggga ccgacgcagg
     4141 gaccgacaac ggccaggcgg agctgcccga gggccagggc gccagcacgg acgcgtccga
     4201 tgagacgacc gtggagcgca gcgcgcgctt cgagcgggac gcgctcgaat tcctcgacca
     4261 gatgtactcg gccgccctgc gcatgacgcg caacccggcc gacgccgagg acctggtgca
     4321 ggagacgtac gccaaggcgt acgcgtcctt ccaccagttc cgcgagggca ccaacctcaa
     4381 ggcttggctg taccggatcc tcaccaacac cttcatcaac tcctaccgca agaagcagcg
     4441 cgagccccag cgctccgccg cggaggagat cgaggactgg cagctcgccc gcgccgagtc
     4501 gcacatgtcg accggtctgc gctccgccga gtcgcaggcg ctcgaccacc tgcccgactc
     4561 ggacgtgaag gaagcgctgc aggcgatccc cgaggagttc cgcatcgccg tctacctcgc
     4621 ggatgtcgag ggctttgcgt acaaggagat cgcggacatc atggggacac ccatcggtac
     4681 ggtgatgtcc cggctgcacc ggggccgtcg tcaactgcgc ggcatgctgg aggactacgc
     4741 ccgcgagcgt ggtctggtcc cggcgggcgc cggagagtcg aacgaagcga aaggctcggg
     4801 ctcatgagct gcggagagcc gcacgagacg gactgcagtg aggtcctcga ccacctgtac
     4861 gagttcctcg acagcgagat gccggacgtc gatcgcgaca agttccagca ccacttcgag
     4921 gaatgctcgc cgtgcctgga gaagtacggc ctggagcagg ccgtgaagaa gctggtgaag
     4981 cggtgctgcg ggcatgacga cgtgcccgcc gacctgcggg ccaaggtcat gggccggatc
     5041 gagctgatcc gctccgggca gaccgtgtcg gaacgcgacg tgaccaaggc ccccgcggca
     5101 ccgcaggagt cctgaccccc aggggccacc ggaaagatca cgcaagggat cacgcacggg
     5161 gcgtatcacc cgaacgtgct aatcctcagg tcataagccc cgaacccccc gatcccgccc
     5221 tacgctccga gcctggacag gcacggtcgg gggatcgggg aggggcgtga tggacgcggt
     5281 accggcgagg gcacgcggct atgtggccgc cgtcgccctc ctgaccgtcc tctgcctgct
     5341 gcccctgccc gccgggcaca ccccctgggg ggcgctcggc ctactcgccg cgctctgcgc
     5401 ggtctgcgag cacgccgtac gccgccgctt cggcggcacc ttctacccgg tcctgctcgc
     5461 cggcgcgttc ctgctgcccc cggccgccgc cgcgctcgtc ccggtgcccg ccgggctgct
     5521 ctccccggtc gcccaccggc ccgccctgcc ccggcgggtg tggcgggccg cgcagcccgc
     5581 gctcgccgtg tgggccgcct cccgggtgca cggcacgctc ggcggccggg acgccgtcgc
     5641 cggctccgac ttcccgcacg ccctgctgcc cgccggcgcg gccgtgctcg ccttctgcct
     5701 ggtgctcacc gtgctcgacg gcgggctgcg cgctgcggtc ggcctggtgc cgccgcgccg
     5761 ggcctggcgc ggactgctgg cccgctccct cgcgcccgtc gcggtgcacg gactcgccgg
     5821 cctgatgatg gccgtgctgt ggcgcagccc ctacggcccg gtcgccgcgc tgctcgtgct
     5881 gctgccgatg tgcgtctcct ggtgggtgtt cgcccagtac caccgcgaac gcgcggccca
     5941 ccaggccacc atccgcgccc tcgtccaggc cgtcgacatc aaggacggct acacccgcgg
     6001 ccacagtgaa cgcgtcggac acgcctccgt cctgatcgcc cgtgaactcg gcatggacga
     6061 cgaacgcgtc gaggtgctgc gcttcgccgg catcctgcac gacgtcggca agctgggcgt
     6121 gcccacccgg ctgctgcgca agaacggccc gctcaccccg gaggaacgac ggatcatcga
     6181 gctgcacccc gagtacggcc acgagatggt ccgcggcatc tccttcctcg gcgaggcccg
     6241 cgcggccatc ctccaccacc acgaacggct cgacggcagc ggctacccgt acggcctggc
     6301 cggcgaccgg atccccgagt gcgcccggat cgtcgccgtc gcggacgcct tcgacgccat
     6361 gacctccacc cgctgctaca gccgggcccg cccggtcgag gccgccgtgg ccgaactgga
     6421 gcgctgcgcc gggaagcact tcgacccccg catggtcggc gcgctcgtcc gcgccctggc
     6481 ccgctccggc tggcacccgg cggtcaccgc cgacgaaccg gcgcaggaca ccccgaccgc
     6541 cgggcgggcc gccgacagcg gggcgccccg atgaccgcgc tgcggctcat ccacggcgcc
     6601 gccgccctcg tggcggccgg ctccctcgcc gtcaccctgt ggaccggcct ggaggaccgc
     6661 ggcgtcgcgc tcgccttcgg gatgctcata accgtcggcg agctgacccg gtggagcgac
     6721 gcccaggcac ggcggcaggc cgcgcccctc ggcgccgccg gctccatggc gtacgccctg
     6781 ctgggcgccg acgccgggcg gcccggtcac cacgacgccg cccaggtcat caccgtcgtc
     6841 ctcgtcgcca ccctgctcgg cgccgtcccg cacatctggt ccggcggcag ccccaccgtc
     6901 gatcacctgg cccgccgcct gctcaccgtc ggcttcgccg ccgtctgctt ccaacccctc
     6961 tacagccagg gcgtcttcgt ctcctggggc ggccccgcct acgccctgct gctgctcacc
     7021 ctgctcgccc tcacctccct gtgcggcgcc gtcctggccg ccgcgctcgc ccacagccgc
     7081 acccgctggc cgttcggccc gctgctgcgc gaggaactgc gcggcctgct cggcatcggc
     7141 tccaccgtct gcgcgaccgg cgcggtgatg gcgctcgcgg tcgccgtcgt cggcctgtgg
     7201 gcgctgcccg tgttctgcct gcccatgctg ctcgtccagc tgtccctgcg ccggtacacg
     7261 gccgtccgcg ccacctaccg gcagaccatc gcctccctgg cccgcgccac cgagatcgcc
     7321 ggctgcaccc ccgccgggca cgcccaccgc gtcgccgcgc tcagccaggc cgtcggccgc
     7381 gacctcggcc tgaccggccg cgaactgacc gtcctggagt acgcggccct gatgcacgac
     7441 atcggccagc tcagcctggt cgacccggtc ccgggcggcg ccaccgcggc gctgcccgcc
     7501 gcggagcagc ggcgcatcgc gctgctcggc ggggccgtcg tccggcagac cggcgtcgac
     7561 gcggccgtcg cggtcgtcgt tgagcggcag gccgatccct acccggagca gccgctcgcc
     7621 gcccggatcg tgcgggccgt caacgcctac gacgagatga cccgggacgc cggccccgac
     7681 ggtcccctgc gtgcgctgga ggagctgcgt ctgggcaccg ccggggacta cgctcccgag
     7741 gtcgtggagt cgctcgcccg ggtgctggcc cggccgccgg gcggccgtga gcgggtgtcc
     7801 gtgcggagaa cgggactgtc tgaccccgtg cccggctggg taacccatgg gtaatgagcg
     7861 cctttcccgc cgcacgtggt tggatgcgag ggagagggtg tccgggggca caagccagcc
     7921 cacagcggga aatggaactg gcaggcggga atcgtgagga tcttcggcaa gggacggcac
     7981 cggccctccg cctcctggcg gcaggccacc gaccgggcgt tcacactcat cggggacggc
     8041 cggtacgagg acgcgggcga gctgctgaca cgcgccgccg atctggaacc ctggatgtcg
     8101 gagtcctggt tcaacctcgc cctgctgcac aagttccggc acgactggga gcaggcccgc
     8161 gcggccggac tgcgcgcggt cgccctgctc gaccgcgaga ccggggcgcc cgactggtgg
     8221 aacgtcggca tcgccgcgac cgccctgcag gactggccgc tggcccgccg cgcctggcag
     8281 gcgtacgggc tgaaggtgcc cggggcctcc gcggccgccg cggaacccgt cggcatggag
     8341 ctgggcagcg cggccgtacg gctctccccg gagggcgagg ccgaggtggt ctggggccgc
     8401 cggctggacc cggcccggct ggaggtgctc tccatcccgc tgccctcgtc cgggcggcgc
     8461 tggggcgagg tcgtcctgca cgacggcgtc ccgcacggcg agcgcaccac ctccaccggg
     8521 cactcctacc cggtcttcga cgagatcgag ctgtgggcgc cgtcgcccgt gcccacctgg
     8581 gtggtccttc tggaggcggc caccgaggcc gaccgggacg cgctggagca gctggccgcc
     8641 gacgccgggt tcgccgcgga ggactggtcc tcctcggtgc ggctgctgtg ccggatgtgc
     8701 agcgagtccc ggatgccgtc ggacgagggc gagggcgtcc acctcgaccc gcacgaccac
     8761 agcgagcccg ggcaccccgg gccgctggga caccgcacgg acgggcagct gtgggtgccc
     8821 gagcgggagt gcggggtggc cgcgccggcc tcgctggtcc ggggtctgct cgacgggtgg
     8881 gtcgccgaca gtccggattc gcgtgactgg cgggacctcg aagaggtgtg ctgaggactg
     8941 cgtgcgccca cgcggcggag ccgcatgtcg gacggcgtcc cgcgccgctc cggggcgcct
     9001 gcacgtaacc tgtaccagca acatctcccc ggttctttga ggaaggcgta cgtcggtcat
     9061 ggcgcagcag gacaccgatc agcagcacgc gggcgtgctc cccgtcgacg acgagggcta
     9121 cgtcgtcgac acggaggact gcgaggagcg cgagagggcc tggcgcgagc gcggcacctc
     9181 gcggccgatc acggtcgtcg gcaacccggt gctgcacaag gagtgcaggg acgtcaccga
     9241 gttcggcgag gagctgcagc agctggtcgc cgacatgttc gccagccagc gcaccgccga
     9301 gggcgtgggc ctggccgcca accagatcgg tgtcgacctg aaggtcttcg tctacgactg
     9361 ccaggacgac gagggcgtcc ggcacgtcgg cgtggtgtgc aacccgaagc tggtcgacct
     9421 gcccgccgag cggcgccggc tggacgacag caacgagggc tgcctgtccg tccccacggc
     9481 ctacgcgtcg ctcccgcgtc ccgactacgc cgaggtgacc ggccaggacg agcagggcaa
     9541 cccgatcagg gtccgcggca ccggatactt cgcgcgctgt ttgcagcacg agaccgacca
     9601 cctctacggc tacctgtaca tcgaccggct gtcgaagcgg gaccgcaagg acgcgctgcg
     9661 gcagatggcc gagaacgagc cacgctaccc cgtcgtcgcc aacgactgac cagcgcagcg
     9721 cacttggggc gcccggccgg atcctccctg gccgggcgcc ttcgtgttgc ccggttcgtt
     9781 cgggagtgcg tcgtacaacc gatcccttcc actggtgcta ctgatccttt atcagtcacg
     9841 caagggggga ttctcggcac cgtggggtag tgagtgaagc aaatccgttc ccacggcggt
     9901 cagttgtggt gctgaatgga cgtgggggat acgcaccggc gcacgccccg gcacaacggg
     9961 aggggtgtgc gcttcctggc ggctgagagg ggtttgttct gtgcatgctt tcccacacag
    10021 caccacagcg acggcgacgg cggtcgtagt cccacccgca ctggcactcc cggtgatcga
    10081 gtcggccttt ccccggcaac tgcatccgta ttggccacga ctccaggaga agacacgccg
    10141 ctggctcctg gaaaaacggc tcatgccgcc ggccaaggtg caggaatatg ccgatggact
    10201 gtgctacacc gatctcatgg cggggtacta caccgacgcc tccgacgacg tcctgcaggc
    10261 catagccgac tacagtgcct ggttcttcgt ctgggacgac cgccacgacc gcgacatcgt
    10321 gcacggccgg gcgggcgact ggcggcggct gcggtaccgg ctgcacgcgg ctctcgacgc
    10381 acccaggcac catctgcacc accccgaccc gctggtggcg ggcttcgcgg acagcgtgct
    10441 gcggctctac ggcttcctgt cgcgcacctg gaaccagcgg ttcgcccggc acttccacgc
    10501 ggtgatcgag gcgtacgacc gggaattccg caaccgcacc cggggacaca tacccggcgt
    10561 cgaggagtat ctcgccctgc gccgtctcac cttcgcgcac tggatatgga cggacctcct
    10621 cgaacccagc gccggatgtg aactgccgga agcggtgagg aacaatccgg cgtaccgtcg
    10681 ggcggcattg ctcagtcagg aattcgccgc ctggtacaac gatctctgct cgctgccgaa
    10741 ggaaatagcg ggcgacgagg tgcacaatct cgggatcagc ctcatcaccc atgcggggct
    10801 gaccctcgaa gaagcggtgg acgaagtcag gcggcgcgtc gaggaatgca tcagtgagtt
    10861 cctcgaagcc gaacggaaag tcctgcaatt cgcccgcgac ctcgacgacg gaacggtccg
    10921 cggcaaggaa ctgagcgccg ccgtccggtc ctgcgtcggc gccatgcgca actggttcgg
    10981 ctccgtctac tggttccacc acgagtccgg ccggtaccgg gtcgacagct gggaagaccg
    11041 gtccacgccc ccgtacgtca cgaacgaaac ggcaggtgag aaatgaccgt cgagtcggtg
    11101 agcccccaga gtccccagag ccccgcgacc cccgccgcac catcgcccga actgcgcgaa
    11161 ccgccgctgg ccggaggtgc cgtaccggtc ctcggccacg gcctgaggct ggcccgcgac
    11221 ccgctcgcct tcatgtccgg gctgcgcgag cacggagacg tggtacgcct gaagctcggc
    11281 cccaagacgg tgtacgccgt caccacaccg gccctcaccg gagccctggc cctcagcccc
    11341 gacttcaaga tcgacggtcc gctgtgggag tccctggagg gtctgctcgg caaggagggc
    11401 gtggccaccg ccaacggccc ccggcaccgc cggcagcggc gcaccatcca gcccgccttc
    11461 cggctcgacg ccttacccgg ctacggcccg gtgatggagg aggaggcaca cgcgctgacc
    11521 gagcgctggc agcccggctc gaccgtcgac tgcacctccg agtccttccg ggtcgccgtc
    11581 cgcatcgccg cccgctgcct gctgcgcggc gagtacatgg acgagcgcgc ggaacggctc
    11641 agcaccgacc tcgccaccgt cttccgcggt atgtaccgca ggatggtgat cccgctcggc
    11701 ccgctctacc ggctgccgtt cccggccaac cgcgaattca accgggcgct ggccgatttg
    11761 catctgctgg tggacgagat cgtcgccgag cggagggcat ctggtcaaaa gccggacgat
    11821 ttgctgacgg cattgctgga ggcgaaggac gacaatggcg atcccatcgg ggaacaggag
    11881 atccacgacc aggtcgtcgc gatactcacc cccggcagcg aaacagtggc gtccacgatc
    11941 atgtggctgc tgcaggtcct cgccgaacac ccggaacacg ccgagaaggt acggaccgag
    12001 gtcgaatccg tgaccggtgg ccgacccgtc ggattcgagc acgtccgctc actcacgcac
    12061 accaacaatg tcgtcgtcga ggccatgcgg ctcaggcccg ccgtatggat attgacccgg
    12121 cgcgcggtga ccgacaccgt actcggcggc tatcgcatcc cggccggggc ggacatcgtc
    12181 tacagcccgt acgccatcca gcgcgacggc cgctcctacg cccgccctct tgacttcgac
    12241 cccgaccgct ggctgcccga gcgggccagg gacgtaccga agtacgccat gagcccgttc
    12301 agcgtgggca accgcaagtg ccccagcgac cacttctcca tgacccagct cagcctgatc
    12361 accgcggcgg tctcggcgaa gtaccgcttc gagcaggccg gcgggtccga cgacaccacc
    12421 cgcgtcggca tcaccctccg cccgcacgac ctgctcctgc gggcgatccc ctggtaggcc
    12481 cggcaccggc gcgcgctcag gcggcccgcg ggcccctgaa cgcgcgccgg taggcgttcg
    12541 gggtcgtgcc cagcgcccgg aggaactggt ggcgcagcgc cgcggccgta ccgaacccgg
    12601 tgcgccaggc gatggtgtcc atcgtctcgt ccgtaccctc cagcaactcc tgtgccagca
    12661 gcacccgttg gcgcaggatc cagcggtagg gggtggtccc ggtctcctgc tggaagcgcc
    12721 gcgcgaaggt gcgcggcgcc atgtgggcgc gggcggcgag ctgctcgacc gtgacctcct
    12781 ggtcgagatg ggcctccatc caggccagca cctccccgac cgtgtcgcag ggcgtcttcg
    12841 gcagcggccg ttcgatgaac tgcgcctgtc cgccgtcccg gtgcggcggc accaccatgc
    12901 ggcgggcgat cttgttggcc acctccgggc cctgctcctt gcgcacgagg tgcagacagg
    12961 cgtcgatccc ggcggcggtg ccggccgagg tgatcacagg gtcctcgtcg acgtacagca
    13021 cgtccggctc gacggtgagc cgggggtagc gccgggagag ctgttcggcg tggtgccagt
    13081 gcaccgcgca ccgccgcccg tccagcagcc cggccgcggc cagcaggaac accccggagc
    13141 agacgctcag cacccgcgtg ccgcggtcca cggcccgccg cagcgccgcc agcagctccg
    13201 gcggatactc gcgctccgca tacgcctcac cggccggtac ggcgatcaga tcggcctcct
    13261 ccagccgctc caggccgtac ggcgtggaca cggtgaaccc gcagtgcgtg cccagctcgg
    13321 gcccctccgc cgacaccacg gcgaagtcgt acacgggcag cccctcgtcg ctgcggtcga
    13381 tgccgaacac ctcgcacacg acacccagct cgaagggatg caccccgttc agcagcacgg
    13441 cggccacgtt cttcagcatg ctgccagtgt gcctcgccag tggcagtaat tcgagggtct
    13501 acggcagtcc tgccactgcc ggtaaggagt atccggcgcg acagtggtgt ccatgaacgg
    13561 aaaccagatc gaaggcctca tcggaatgct cgccaccctc gggatcctgg tcctgctggt
    13621 cctgccctcc gcgctcggtg tcctgcgcga ccggcgcatc gaccggcaga tcaggcaggc
    13681 ccggcagccg ggggcaccca accggccggc gcaggagccc cggcgccacg gcaggcgcca
    13741 cggcgcggcc cgtcccgcct gacacaaagc gccctgacgc tgctgaccgc gacgggcgcc
    13801 cacgcggagg gcaggggaga catccgcgtg gtgaagaccg tcgtcaacaa gggcgggaac
    13861 gtgatcgtcg ggacgtcgaa gaaggtgacg ttcccccaca gcgacgacgc cgacagcaac
    13921 aggctggccg gtgtctggca ggtcaacgcc accgtcaagg cgaacgacgg cgactacggg
    13981 atctccgacc gtggcccagg gtgccgggcc gaccgtcacc ggcaagctgt cccgggcgaa
    14041 ctgggaggac ctgaagtacc agaggaccgt gcgcacgggc gacgccggaa ggctcggcac
    14101 caaggtcacc gtcatctcgg cgggcagccg gcgctggtgc ttccccggca cgacgacgac
    14161 cgcgcggatc gtgtcggccg gggacgcggt gaagctgaag taacggccgc tcagaagtcc
    14221 tcgtccaggt cgaccgtgcc ttccacggcg acctggtacg ccgacgggcg gcgctcgaag
    14281 aagttcgtca gctcctggac gccctggagt tccatgaagg agaacgggtt ctccgagccg
    14341 tacaccgggg cgaagccgag gcgggtgaga cgctggtcgg cgacgcattc gaggtactgc
    14401 cgcatggagt cggtgttcat gccgggcagg ccgtcgccgc acaggtcgcg ggcgaactgc
    14461 agctcggctt cgacggcctc cttcagcatg tcggtgacct cctgcccaag ctggtcgtcg
    14521 aagagctcgg gttcttcctt gcggacggtg tcgacgacgt cgaaggcgaa gctcatgtgc
    14581 atggtctcgt cgcggaagac ccagttggtg ccggtggcga ggccgtgcag gaggccacgg
    14641 ctgcggaacc agtagacgta ggcgaaggcg ccgtagaaga agagtccttc gatgcaggcc
    14701 gcgaagcaga tgaggttgag caggaaacgg cggcggtcgg ccttggtctc caggcggtcg
    14761 atcttctcga cctcgttgat ccacttgaag cagaactccg ccttctcgcg gatggagggg
    14821 atgttctcca cggcggcgaa ggcggcggcg cggtcgtccg ggtcgggcag gtaggtgtcc
    14881 agcagggtca ggtagaactg gacgtggacg gcttcctcga acagctgccg gctcagatag
    14941 aggcgcgctt cgggggagtt gatgtgcttg tagagggtga gcaccaggtt gttcgcgacg
    15001 atcgagtcgc cggtcgcgaa gaacgcgacg aggcggccga tgaggtgctg ctcctcgggg
    15061 gtgagcctgg ccaggtcggc gacgtcggag tggaggtcga cctcctcgac ggtccaggtg
    15121 ttcttgatgg cgtcccggta gcgctcgtag aagtcggggt agcgcatggg gcggagagtc
    15181 aactcgaagc cggggtcgag caggttggtg tttcggctgg tcattactgg caggcctcgc
    15241 aggactcggg gttttccagg gagcaggcga ccgcgtcggg ctcggcgatc tgctgcacgg
    15301 ggacgggctt ggcggcctgc gcctggccct gggcggcgcg ggcgatgcgc gtcgcgggac
    15361 gcgagcgcag gtagtacgtg gtcttcaggc ccgacttcca ggcgtaggcg tacatcgagg
    15421 agagcttgcc gatggtcggc gtctccagga acaggttgag cgactgggcc tggtcgagga
    15481 agggggtgcg ggcggcggcc atgtcgatga ggccgcgctg ggggatctcc caggccgtgc
    15541 ggtacagctc acgcacgtcc tgagggatcc agaggaagtc ctgcaccgag ccgttggcct
    15601 cgcgcagggc ctcgcgggtg cgggcgtccc agacgccgag gtccttcagg tcctgcacca
    15661 ggtaggagtt gacctggagg aactcgccgg agagcgtctc gcgcttgaac aggttggaga
    15721 cctgcggctc gatgcactcg tacacacccg cgatggacgc gatggtggcc gtcggcgcga
    15781 tcgcgaggag cagcgagttg cgcatgccgg tctccgcgat gcgcctgcgg agggcgtccc
    15841 agcgctccgg ccaggtcagg tcgacctcgt agtggtcggg gtggaggacg ccgcgggcgg
    15901 cgcgggtctg ctcccaggcg ggcagcgggc cgttgcgctc ggcgaggtcg gcggaggcct
    15961 cgtaggcggc gagcatgatc cgctcggcga tccgggtgga cagggccttg gcctcggcgg
    16021 agtcgaaggg caggcgcagc ttgaagaaga cgtcctggag gcccatcgcg ccgaggccca
    16081 cggggcgcca cttggcgttg gagcggcccg cctgctcggt cgggtagaag ttgatgtcca
    16141 cgacccggtc gaggaaggtg acggcggtgc ggaccgtccg gtccaggcgc tcccagtcga
    16201 tgtcggcgtc ccgcacgaag gcgccgaggt tgatcgagcc gaggttgcag acggcggtct
    16261 cgccgtcgtc ggtgacctcc aggatctcgg tgcagaggtt ggaggagtgg atgacgttgc
    16321 cgggctcggc ggtctggttg gcggtgcggt tggcggcgtc cttgaaggtc atccagccgt
    16381 tgccggtctg cgcgagggtg cgcatcatcc ggccgtacag ctcccgtgcg ggaagggtct
    16441 tcctggccag gccggcggcc tcggccttgc ggtaggcggc gtcgaactcc tcgccccaca
    16501 ggtcgaccag ctcggggacg tcggcggggg agaacagcga ccactgcgcg tcggcgttga
    16561 cccggcgcat gaactcgtcc gggacccagt gggcgaggtt gaggttgtgg gtgcggcggg
    16621 cgtcctcgcc ggtgttgtcc cgcagttcca ggaactcctc gatgtcggag tgccaggtct
    16681 ccaggtagac cgcggcggcg cccttgcgcc ggccgccctg gttcaccgcg gccacggacg
    16741 cgtccagggt cttcaggaac ggcacgatgc cgttggagtg cccgttcgtc ccccggatca
    16801 gcgaaccccg cgagcggata cgggagtacg acagcccgat gccgccggcg tgcttcgaca
    16861 ggcgggccac ctggtggtag cggtcgtaga tggagtccag ttcgtccagc ggcgagtcca
    16921 gcaggtagca ggacgacatc tgggggtgcc gcgtgccgga gttgaacagg gtgggggagg
    16981 acggcaggta gtccaggcgg ctcatcaggc cgtacagggc cgcgacctcg tccaccgagc
    17041 ggggcgtgtc gtcctcggcg aggccgctgg ccacgcggag catgaagtgc tggggcgtct
    17101 cgacgacctt gcgggtgatc gggtggcgca gcaggtaacg gctgtagagg gtgcgcaggc
    17161 cgaagtagcc gaagcggtcg tcggccgagg cgtcgaccag tgcgtcgagc cgctcggcgt
    17221 gcaggcgcgc gaactcggcg gtgcggtcgg cgatgaggcc ctcgcggtgc ccgaccgcga
    17281 cggactcggt gaaggacgtc acgccctgcg aggcggcctc gtcccggatg gtgagggtca
    17341 gcagccgggc ggccagcttc gagtaggcgg ggtcctcgga gatcaggccg gcggccgcct
    17401 ccgtggccag ctcacgcagc tccgcctcgt cggcccgcgc ggaccggccg cgcagcgcgg
    17461 cggcggcgat ccggcccggg tcggcgtcgg gcaggtcggc ggtcagctcg gtcagggtcc
    17521 gcagcagtgc ggtcccggga ccgtcggtct ccagttcgct gactgaagcc gggtcggctg
    17581 gcgcgatggt cacgtggggc tctccctcag ctcggcacgg gggcccggcg gagggcagga
    17641 ggcagccacg agcgcgcacg gcgtcgcgtc caccggccca ctccacgagg cccggacgtt
    17701 cggaacccac ccggaccgga cgtccgggtg tgctgccggc aggtcgtcgg actcaacagg
    17761 cgcgcggatg cacgcaggta caccgttgcg ggacagttcc ggactcgcac cggattcccc
    17821 tgcggcgaca gcgatcacga gcatacatct agtgccgggt tctcatgtca cccccagatg
    17881 ttgtgccggt ccggtgtcgg gggccacttg ccgggcggcg gcgcggacgg tgcgtgcttc
    17941 ctgggaagca gttgcccgcg gggtcccggg tgccgggaag acgggcctcg tgcaccaacg
    18001 ccgaccgggt cgtgcggacc gttgccgtgc tcgccgcgtt cgcctggggg cgcagggcgg
    18061 gtacaccctg gtctcgcgta ccaccgggcc gggcggcacc acctcgtgcg gccgtctcgg
    18121 cgatgcccgg gcgtacccgc gacgaagccc tgccgttcgg ttcatcccgg cggcgcgggg
    18181 cggccggctg atccgaacga cagggctcgg ggccccgatc gaggcgtggg ctagtgcgcg
    18241 ctgcccgcgg tggccggcgg cagctccacc tgcaccccgg ggtcgcccgc gtcggccgtg
    18301 tagtcctgcg gcctggtctc gtcgacgccg tcgggggcct tcacggccct caggacgacg
    18361 gtcaggacca cggtcaccag aacgttcagg acgaacgccg tcaggccgat gtagccgatc
    18421 tcgccgatgc ccgggatctc cttggcgttg ccgccgaagt gcttctgggt cggcgaggcg
    18481 atgccgtacg cggcggccgt gccgtagatc atgccggccg cccagccggc gagcagcgcc
    18541 cagcggtgga accagcgggt gaacaggccg ccgaccaggg ccgggaaggt ctgcaggatc
    18601 cagatgccgc ccagcagctg gaagttgatg gcgacggtct tgtccatggt gaggacgaag
    18661 accagcgcgc cgaccttcac cagcagcgac accagcttgg agaccttggt ctcctgctgg
    18721 gccgtcgcgt cgggcttgat gaagtccttg tagatgttgc gggtgaagag gttggccgcc
    18781 gcgatggaca tgatcgccgc cgggaccagg gcgccgatgc cgatcgccgc gaaggccacc
    18841 ccggcgaacc agtccgggaa catgtcctcg aacagctgcg ggatggccag ctggccgttg
    18901 ccgaccttca ccccggccgc gatcgccatg aagcccagca gcgccagcag acccagcatc
    18961 agggagtaca gcggcaggat cgtggtgttg cggcggatca cctcacggct cctggacgac
    19021 agggtcgcgg tgatcgagtg cgggtacatg aacagcgcga gcgcggagcc gagggccagc
    19081 gtggcgtacg tccactggtt cgcctccccc ggggccagcg cgccgcgcgg cttcccggtg
    19141 tccgggttca cctggccgag cgcgtggccc gccttggcga agacgtcgtc gaacccgccc
    19201 agcttgatcg ggatgtagat gatcgccacc gcgatgacga tgtagatcag cgtgtccttg
    19261 acgaacgcga tcagcgcggg ggcgcgcagg cccgaggagt acgtgtacgc ggccagcacg
    19321 ccgaaggcga tcagcaacgg caggtccttc acgaaccagt tggtgttctc gccgccgccg
    19381 acgcccatca cgtccagcac ggcctggatg ccgaccagtt ggagcgcgat gtacggcatg
    19441 gtcgccagga tgccggtcac cgccaccgcc agcgacaggc ccttcgaacc gaaccggccg
    19501 cgcacgaagt cggaggtggt gacgtacccg tgccggtgcg agaccgacca caggcgcggc
    19561 aggaaggtga agatcagcgg gtacaccagg atcgtgtacg gcaccgcgaa gaagccggac
    19621 gcgcccgccg cgtagatcgc cgccggtacg gcgacgaagg tgtacgccgt gtacaggtcg
    19681 ccgccgagca ggaaccaggt gatccaggtg ccgaaggacc ggccgcccag accccactcg
    19741 tccagggagt gctcgttctc ggccctgcgc cagcgcgcgg ccaggaagcc catgaccgtg
    19801 acggccagga agaagaagat gaagacgccg agcgcgacgc cgttgacgcc gtccttcact
    19861 tcgccgcacc cccgttcgca cccttgcggg cgcgctggtc acgctgccag agcttgtacg
    19921 ccagcatggt gagcgcggtg gagatcagca cccagagcat ctggtaccag tagaagaacg
    19981 ggatcccgat gaacgcgggg tcggtcttgg cgtacgagcc gacccagagc atcgccacga
    20041 agggcgcgac gagacacagt gcgatgatca cccggcccgg cgtcaccacc ggtggtctca
    20101 cttcaggcgt ttcggacatg ccacggctcc gtcccctcgc tgatcacctg ggtaatgcgc
    20161 aggcaatcta ggtgacgccg tcgtggcagt ggaagacctc gtccgcatct cggtatatcg
    20221 attcagcgaa cgtgcctggc ggttactccg cgggccgctt cagccgggcc acgaacttgt
    20281 accggtcccc gcggtacacc gagcgcaccc actccaccgg ctggccctcg cggtccagcg
    20341 agtgccggga gagcatcagc atcggcaggc ccacgtcggt gccgagcaga cccgcctcgc
    20401 gcggggtggc cagggaggtc tcgatggtct cctcggcctc ggcgaggtgg acgtcgtaga
    20461 cctcggcgag cgcggtgtac agcgaggtgt acttcgccag cgagcgtctg agcgccggga
    20521 agcgcttggc ggacaggtgg gtggtctcga tcgccatcgg ctcgccgttg gccatgcgca
    20581 gccgctcgat gcgcagcacg cgcccgccgg gggcgatgtc gagcagctcg gcgagccggt
    20641 cgtcggcggt gatgtacccg atgtccagca gctgcgaggt cggctccagg ccctgggcgc
    20701 gcatgtcctc ggtgtaggag gtgagctgga gggcctggga gaccttgggc ttggccacga
    20761 aggtgccctt gccctggatg cgttccagcc ggccctccac caccagctcc tgcagggcct
    20821 ggcgcaccgt ggtgcgggag gtgtcgaact cggcggccag cgtgcgctcc ggcgggaccg
    20881 gcgtgcccgg cgcctgggtc tccgtcatgt cgagcaggtg cttcttcaag cggtagtact
    20941 tgggcacgcg cgcggtacgg gtggtgccga cctcgttctc cgcactgctg acgtcggtgc
    21001 tcatgctctg ccttcccggc tccggatgcc gaaagcgacc gacatccccg tcggccacgg
    21061 ctcacatcgt ggcatgggtt gtcgtg
//
