LOCUS       NZ_CP071839            23178 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4990385
            Orig. end                         :: 5013563
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..23178
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="azole-containing-RiPP"
                     /region_number="16"
                     /rules="((YcaO or TIGR03604) and (((thio_amide and (PF06968
                     or PF04055 or PF07366)) or Lant_dehydr_C or Lant_dehydr_N
                     or (PF06968 or PF04055 or PF07366)) or (goadsporin_like or
                     PF00881 or TIGR03605)) or TIGR03882 or TIGR03603 or
                     thiostrepton or TIGR03602)"
                     /tool="antismash"
     cand_cluster    1..23178
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="((YcaO or TIGR03604) and (((thio_amide
                     and (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /kind="single"
                     /product="azole-containing-RiPP"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23178
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13178](-)"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..13178)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="((YcaO or TIGR03604) and (((thio_amide and
                     (PF06968 or PF04055 or PF07366)) or Lant_dehydr_C or
                     Lant_dehydr_N or (PF06968 or PF04055 or PF07366)) or
                     (goadsporin_like or PF00881 or TIGR03605)) or TIGR03882 or
                     TIGR03603 or thiostrepton or TIGR03602)"
                     /neighbourhood="10000"
                     /product="azole-containing-RiPP"
                     /protocluster_number="1"
     gene            324..2006
                     /locus_tag="S1361_RS22435"
                     /old_locus_tag="S1361_22405"
     CDS             324..2006
                     /EC_number="1.2.1.70"
                     /GO_function="GO:0008883 - glutamyl-tRNA reductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674185.1"
                     /locus_tag="S1361_RS22435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22405"
                     /product="glutamyl-tRNA reductase"
                     /protein_id="WP_208033590.1"
                     /transl_table=11
                     /translation="MSLLVVGLSHRSAPVSVLERATLSADAQVKLVQDTVAAEPATEAA
                     VLATCNRIELYADVDKFHAGVAELSTLLARHSGVGLEELTPYLYVHYEDRAVHHLFSVA
                     CGLDSMVVGEGQILGQIKDSLARAQDLHSAGKLLNDLFQQALRVGKRAHSETGIDRAGQ
                     SLVTFGLEQLAAGGDVQDWASGRTALVIGAGSMSSLAAATLARAGVAEVVVANRTFDRA
                     ERLARILTEEGDTEVTARAVRMDAVAAELTRADVVVSCTGATGLVLTAEAVAQAVEGRT
                     GRPVADTGVTAVRPASPPRSTGVGADENCPLDLAAVQPGFSVMGEAAVAGMDAATLEQH
                     AAWVDKGTTVDRRERRTPEADAELITALAATVATVGRIPERRKPEPVAERPAPSFFLLD
                     LAMPRDIDAAVHRLAGVRLVDIESLAEASADAPMAADVDQVRRIVSDEVAAFGAAQRAA
                     HITPTVVALRTMAADVVASEIARLDGRLPDLDERQRGEIRQAVHRVVDKLLHAPTVRVK
                     QLAAEPGGAGYADALRTLFDLDPETVAAVSRAVDSTQTKDRPA"
     gene            2003..2998
                     /gene="hemC"
                     /locus_tag="S1361_RS22440"
                     /old_locus_tag="S1361_22410"
     CDS             2003..2998
                     /EC_number="2.5.1.61"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004418 - hydroxymethylbilane synthase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006779 - porphyrin-containing compound
                     biosynthetic process [Evidence IEA]"
                     /codon_start=1
                     /gene="hemC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007443739.1"
                     /locus_tag="S1361_RS22440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22410"
                     /product="hydroxymethylbilane synthase"
                     /protein_id="WP_208033591.1"
                     /transl_table=11
                     /translation="MTEKALRLGTRRSKLAMAQSGQVAEAVHRVTGRPVELVEITTYGD
                     VSREALAQIGGTGVFVTALRDALLRGEVDFAVHSLKDLPTAQPEELVLAAVPVREDPRD
                     VIVARDALKFTDLPRGARIGTGAPRRMAQLNAYARAHGLDIETVPIRGNVDTRIGYVRD
                     GELDAVVLAAAGLNRIGRIDEATDFLSVDTVLPAPGQGALAIECAAGNAELIAALGELD
                     DPFTRAAVTAERSLLAALEAGCSAPVGALADLPPLSAPFERGDPQADRQIVKEMRLRGV
                     VGTTDGTRMVQLSTTGPVPQTHDQAWALGRELATEMLAQGAAGLMGERAH"
     gene            2995..4707
                     /locus_tag="S1361_RS22445"
     CDS             2995..4707
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TP_methylase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003992057.1"
                     /locus_tag="S1361_RS22445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bifunctional uroporphyrinogen-III
                     C-methyltransferase/uroporphyrinogen-III synthase"
                     /protein_id="WP_208033592.1"
                     /sec_met_domain="TP_methylase (E-value: 3.9e-34, bitscore:
                     117.3, seeds: 87, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPTALPAAGPEHGHVTFLGAGPGDPGLLTLRAVEALSHADVLVA
                     EHEVLDVIRTHARQGVSVVPTDADSSAVSPPGTGTPQLTVVDGTSTPAAVPAAARDAAH
                     LVMEAARGGRRVVRAVSGDPGLDTYAAEEMLACAAAGVPFEVVPGVAAAVGVPAYAGVP
                     LRDAQGADVRFVDARTASDRCWTEVGASDGTVVVSTTLDSVAAAAGELVSAGRKPDTPL
                     TVTVAGTTTRQRTWTATLGTIAQTLKQAKVLPSPDGGRPVIAVVGERSAAARRDQLSWF
                     ESKPLFGWKVLVPRTKEQAASLSDQLRSYGAVPHEVPTIAVEPPRTPQQMERAVKGLVT
                     GRYEWIAFTSVNAVKAVREKFEEYGLDARAFAGIKVAAVGEQTAKALIAFGVKPDLVPS
                     GEQSAAGLLEDWPPYDPVFDPIDRVFLPRADIATETLVAGLIELGWEVDDVTAYRTVRA
                     SPPPAETREAIKGGGFDAVLFTSSSTVRNLVGIAGKPHNVTVIACIGPATAKTAEEHGL
                     RVDVMAPEPSVHKLAEALADFGMKRRAAALEAGDPVTRPSERRPGARRRRTTT"
     gene            4881..5936
                     /locus_tag="S1361_RS22450"
                     /old_locus_tag="S1361_22420"
     CDS             4881..5936
                     /GO_function="GO:0008171 - O-methyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013087.4"
                     /locus_tag="S1361_RS22450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22420"
                     /product="methyltransferase"
                     /protein_id="WP_208033593.1"
                     /transl_table=11
                     /translation="MTLEASAPIGLPGGPYDPPHARLLALAAAKWAAQPIAVLAEMGIA
                     DALADGPRTLADLAAAVEAQPSALRRCLRAAACVGVFAEQEDGRWSLTPMADCLRRDAA
                     TPIRNWVLMLTRGPMWDSFGKLAETVRTGRSAFEVAHGTPLFDYLDKDDAFREVYESAM
                     GELTGELAAELADVVDFGRYGTLVDLGGGDGALLGNLLARYPDCRGVLVERPRVIELAR
                     PRLTALGVADRVRLVPGDATAEVPAGGDAYLVKNMLHCFDDDTALAVLRRVRAAGGADA
                     TLFVVEAVVPPGNDFHWAKLIDIEMLADNDGRERTEEEWRELLHAAGFALDRVCATTPP
                     QSVLIARPLPG"
     misc_feature    5085..5087
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            6001..6177
                     /locus_tag="S1361_RS22455"
                     /old_locus_tag="S1361_22425"
     CDS             6001..6177
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS22455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_22425"
                     /product="hypothetical protein"
                     /protein_id="WP_208033594.1"
                     /transl_table=11
                     /translation="MRAPWKGDPVERARNRARQRVLQEQQDAEQARNRERQERQQAERD
                     ERQRRQQSRSDDD"
     gene            complement(6258..6998)
                     /locus_tag="S1361_RS22460"
                     /old_locus_tag="S1361_22430"
     CDS             complement(6258..6998)
                     /GO_process="GO:0045892 - negative regulation of
                     DNA-templated transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1239: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF014906.4"
                     /locus_tag="S1361_RS22460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22430"
                     /product="TetR/AcrR family transcriptional regulator
                     C-terminal domain-containing protein"
                     /protein_id="WP_208033595.1"
                     /transl_table=11
                     /translation="MAGQRAGRTAGRASRPSITLDAVTAAALRTLQRDGLEALSMRRLA
                     DELSIQAPSLYWYVRNKEELLDLLADALLADLRLDPLVREDGDWQTELRDMMRAYRKYL
                     LGKRDSGKVLAGRLQLGPHFLHHAEVILGPLRRAGFSGQDTAYSLYVLTQYVQGFVLHE
                     TSPLSADVARGTDRMEFLEEVRERLAKLPAEEYPNVVAVGDQLARPDIEARFDYGLDRL
                     LDGLRARLDSAGGAAAAPGDSPAG"
     misc_feature    complement(7064..7077)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 12.89"
                     /tool="antismash"
     misc_feature    complement(7064..7080)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 16.96"
                     /tool="antismash"
     misc_feature    7072..7089
                     /note="TFBS match to ArcA, Repressor of carbon oxidation,
                     confidence: weak, score: 15.37"
                     /tool="antismash"
     gene            complement(7128..8198)
                     /locus_tag="S1361_RS22465"
                     /old_locus_tag="S1361_22435"
     CDS             complement(7128..8198)
                     /EC_number="1.-.-.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1251: luciferase
                     family protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF012517.4"
                     /locus_tag="S1361_RS22465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22435"
                     /product="LLM class flavin-dependent oxidoreductase"
                     /protein_id="WP_208033596.1"
                     /transl_table=11
                     /translation="MKHGISLLPDCRPATRPAQEYYTDVLRLSRLADEAGLDYVKITEH
                     YLKEYGGYCPSPLTFLAAVAAQTSRIRLMTGCVLPAFHHPIQIAAHTGMVDALSGGRLE
                     VGFARAWLPYEFAAFGVPMDESRDRFTDTIAAVRRLWTEEKVTVDSPFFSFREVTSLPA
                     PVQRPHPPVWGAAVRSRQSFAWLAEQGFGLLVTPPPRSEDLAGVRDLVDVYLDTFADVH
                     GDAPGAPRPRVAVSIPLYVAETDDEAYRVADPLLREYLAVWAEAAEAWMNTSSKDYPTY
                     SQMALTLRNLDIADFRSLGTAVVGSPATVLERARRLKEFLSVDTFLWQVDFGGQDGPTM
                     ERSFRLFTEEVLPHLR"
     gene            complement(8195..9244)
                     /locus_tag="S1361_RS22470"
                     /old_locus_tag="S1361_22440"
     CDS             complement(8195..9244)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0070007 - glutamic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="S1361_RS22470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22440"
                     /product="CPBP family glutamic-type intramembrane protease"
                     /protein_id="WP_208033597.1"
                     /transl_table=11
                     /translation="MSGAVTAGVLAVVTAGAYGVLVPCLTRLRRRWAPGRRSWPHPLAR
                     AAAGCAAGCAVLVAAVCLGLLRPPSALPNGTGLALAASGIALGCGEFATAAFAASVAAD
                     TADALRGTRLATLAGRLGAGVTTILTRLGAGAGTALARLGAGVARTGGRRGRRLETPSF
                     SAGRGPADRAGRAHGDRPGGRPARLRPAGAAAARTVDRRPAGAVTARAAERRPASAVGR
                     THWLGLARGHAAEEARASVRAVPWWGAGVLVAVAVCDELSFRAALVPALAGAGAVTAVT
                     AAAAAHTAVRLRDAPAGRRRAPETWVPAVLVPAVHAALFWRTGSVAPLLTADAAYLALL
                     IPTERSRRP"
     gene            complement(9241..10026)
                     /locus_tag="S1361_RS22475"
                     /old_locus_tag="S1361_22445"
     CDS             complement(9241..10026)
                     /EC_number="3.4.-.-"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004222 - metalloendopeptidase activity
                     [Evidence IEA]"
                     /GO_process="GO:0071586 - CAAX-box protein processing
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014566.4"
                     /locus_tag="S1361_RS22475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22445"
                     /product="CPBP family intramembrane glutamic endopeptidase"
                     /protein_id="WP_208033598.1"
                     /sec_met_domain="Abi (E-value: 2.5e-09, bitscore: 36.2,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSLIHIPELRAASAVALALCALSSLALASHLHVRFLDRRGVHTL
                     HVYAAVLAVVTGYGLLVLGPAALYRGPVWGLAAGPLAGAVLAAPVAAADTAITRRLGRR
                     AARSAPPAGPPRAVRTTRAVGLAARVAGARTAGTTERRWTPSHRDTDVALPPGWLVAVG
                     ALEECVFRGVLTGEAMALTGWAVRIAVLTLATAAFALSHLFFGWTQVAAKLPLALAGLA
                     LTLATGDVLGAITVHALFNLRIWRYQNTVRSAGSRAVTP"
     gene            complement(10001..11329)
                     /locus_tag="S1361_RS22480"
                     /old_locus_tag="S1361_22450"
     CDS             complement(10001..11329)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: YcaO"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF014661.4"
                     /locus_tag="S1361_RS22480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22450"
                     /product="YcaO-like family protein"
                     /protein_id="WP_208033599.1"
                     /sec_met_domain="YcaO (E-value: 2.7e-41, bitscore: 141.2,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLRLHQDEEVRVHRLRERMHGPLCGLTTSMGFLTRYPDGPRLLV
                     GTADMTGVHVRQNQPAPKAGSYHIGGYGIFPFESHIRSLAETLERYAGYAAALDGRFTQ
                     RHTSRTALAQAGEPVLPESAFRLFTEEQYAREGFPFQPFHTDAPFGWLLVDSLTGDGPC
                     WVPAQRFLLGYVREADEPWTLPAVTTGTATHTTPQAALRAALEEVVQVDAAMGHWYGRT
                     ESVLIRPDARTRHLDALVDTYFPDSAPRPEFHLLPSPDLPGFTIACLLRQPSGLVPRTA
                     IGLGSGASLPRAMYRALLEAAGVQWLAAWVAVEQAVTGAAPDEAIYDLEGNVGRYATEE
                     GARIVEERFARHTEQPASQLPPDDDREVREAVRTLVDAFASSGKRLYFGDLTTRDLRAL
                     GFHAMRVWSPDTVSLPLPSAVPAAHPRFADYGGFTDDVPHPYP"
     gene            complement(11329..12363)
                     /locus_tag="S1361_RS22485"
                     /old_locus_tag="S1361_22455"
     CDS             complement(11329..12363)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR03882.1"
                     /locus_tag="S1361_RS22485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22455"
                     /product="TOMM precursor leader peptide-binding protein"
                     /protein_id="WP_208033600.1"
                     /transl_table=11
                     /translation="MSDNRQPRVRRTFSVIGHSPDVVELRTGVWNARSYTLTDDSRSGK
                     LFNLVSGLDGTLSRRDLAKREGVSRVEVEALVDHLYGLDAIEEEPRSALDAYLDDMAAL
                     GGPGERPAAEGVVLLGDAELCERTAALLPAELAPDIRIPGPDHPVRARLESLPPSVLHD
                     GLAFGEAAEVLRPWAGRHLLLAERTIDPVRAQLLNRLTRAAGISWTYAAIDGPFLFVGP
                     TMIAGRSSCFECFETRVTMNLRESASYQRYKEALARSAVLAGEPPLYGPVASLLCSHLA
                     MEATNYLACGTTFTVEKVLGCYLPSMELSYQEVLPLPGCPGCGAVPERDDQTLHFDPRT
                     WLED"
     gene            complement(12435..13178)
                     /locus_tag="S1361_RS22490"
                     /old_locus_tag="S1361_22460"
     CDS             complement(12435..13178)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     azole-containing-RiPP: PF00881"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="S1361_RS22490"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22460"
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_208033601.1"
                     /sec_met_domain="PF00881 (E-value: 5.2e-21, bitscore: 74.2,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRWDRASLLSIGYYFSDVMAVVQSRQDRLPRRGAPRTALPEGAQ
                     PSAGLVETILQRRSDRDFTGAPLPLDELATVVRLAGSVTAEADLELTDGTPLTMGFRAV
                     PSAGGLYPVELWLAALRVDGLEPGLHRYLPVEDALARRAGPDALTSLLASFDPQDGQID
                     FERAAAIVLLVGTPWRAMRKYGPRGMRSMFHEAGGIAQNTHLAATALGLRSVDFSGFYD
                     DEAHEAMGLDGTHRVLLHTVLLGAG"
     misc_feature    complement(13235..13247)
                     /note="TFBS match to LuxO, Repressor of luminescence,
                     confidence: weak, score: 19.6"
                     /tool="antismash"
     misc_feature    complement(13248..13261)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 16.71"
                     /tool="antismash"
     misc_feature    complement(13249..13260)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: weak, score: 15.65"
                     /tool="antismash"
     gene            complement(13439..13582)
                     /locus_tag="S1361_RS22495"
                     /old_locus_tag="S1361_22465"
     CDS             complement(13439..13582)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS22495"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_22465"
                     /product="hypothetical protein"
                     /protein_id="WP_208033602.1"
                     /transl_table=11
                     /translation="MKLQSEKVTEHRNSTPQAALEPFGAGRDEAVLVPGACSCCCGAVV
                     RK"
     misc_feature    complement(13691..13706)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 20.59"
                     /tool="antismash"
     misc_feature    complement(13722..13731)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: weak, score: 13.41"
                     /tool="antismash"
     gene            13819..15039
                     /locus_tag="S1361_RS22500"
                     /old_locus_tag="S1361_22470"
     CDS             13819..15039
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012296.4"
                     /locus_tag="S1361_RS22500"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22470"
                     /product="cytochrome P450"
                     /protein_id="WP_208033603.1"
                     /sec_met_domain="p450 (E-value: 8.3e-20, bitscore: 69.7,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVEDNAPVDLLDPAFMADPGPAYERLRSTAPVTRIRLRPGLSPW
                     LISGYEEARTVLSDPVFSVDPARTRPGVREAIAAGRAEEKTALLGRHLLSVDPPDHTRM
                     RRLMSRALTARRMQQLRGPVGTFATELLDALTGRREFDVLGDYALPLAVRVICELIGIP
                     PEDRAAFQRWGSLLVRSELQDDASFDRVSDEMAGYLVPLVAARRAEPADDLVSALVAAH
                     DEERLDDYELISLVYQLFFAGHESSAYLIANATLRLLAHPDERAALAREPERIESLIEE
                     VLRIDGPVKVPTWRFPVRDVDLAGVRLRAGEPVLVLLGAAGRDPRRFPDPDRFDTGRTA
                     VQQHLAFSHGIHHCMGAAVGRMEGQVAVGRLFQRFPELRLAVPPERLRWRDNLMMRGVC
                     ELPVRVG"
     misc_feature    13930..13932
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(15137..16714)
                     /locus_tag="S1361_RS22505"
                     /old_locus_tag="S1361_22475"
     CDS             complement(15137..16714)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00711.1"
                     /locus_tag="S1361_RS22505"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22475"
                     /product="MFS transporter"
                     /protein_id="WP_208033604.1"
                     /transl_table=11
                     /translation="MTADTPAPTGPSPYRTLPALCVPLALTMLQSTVLSTALPDIQDDL
                     SGGIQDIQWVISGYSLAFAALMLTGGACGDRFGRKRTFLTGLAVFLAGSVFSALAGSVW
                     VLVAGQAVLGVGAALLMPNTLSIIRHVFTDSGERGTAIGIWAAVAGAAVAFGPVAGGPL
                     VENFGWAGIFWMYVPVAVIGLLLGMWTVPESASPERRLDLAGLVLSVAAVAALVYATIE
                     GGSRGWSDRLVIGAFVAGGVLLVAFVVTEKLVREPMLDLSFFRDPVFTGAVLAGFVLYF
                     GLFAITYFLMLWLQTVLGWSAVGAGLAILPGMLLAMVAAPPAGWMTGRMGGAVPLTLGI
                     LCSALTMFGASLYGVGAHYSSYWWVVLLVGLGIGLTLTPISTLVMMRVPANRSGMASGA
                     SNATRQLGSVFGVAVLGTLLTTRMTDGVRDRLTDAHVPAEVRDEVVRAVAAGGAQSAGG
                     GGDRRIGALVNAAFVDGLHLAERVGAALLLVTAVVVFLLVRGRDRDDVDTDPAAAPARE
                     KSPADRTS"
     misc_feature    complement(16601..16603)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    16774..16787
                     /note="TFBS match to CatR, H2O2-responsive repressor,
                     confidence: medium, score: 18.86"
                     /tool="antismash"
     gene            16985..17977
                     /gene="hemB"
                     /locus_tag="S1361_RS22510"
                     /old_locus_tag="S1361_22480"
     CDS             16985..17977
                     /EC_number="4.2.1.24"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0004655 - porphobilinogen synthase
                     activity [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0033014 - tetrapyrrole biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="hemB"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019328531.1"
                     /locus_tag="S1361_RS22510"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22480"
                     /product="porphobilinogen synthase"
                     /protein_id="WP_208033605.1"
                     /transl_table=11
                     /translation="MTKYGSFPGTRPRRLRTSPVMRRMVAETRLNPADFILPAFVREGV
                     SEPVPIGAMPGVVQHTRDSLKKAALEAVQAGVSGIMLFGVPEDGKKDARGTAGTDPDGI
                     LQLALRDVRAEVGDDLLVMSDLCLDEFTDHGHCGVLDAEGRVDNDATLERYAEMAQVQA
                     DAGAHVVGPSGMMDGQIGVIRDALDQIGREDVAILAYTVKYSSAFFGPFREAVASSLQG
                     DRKTYQQDPANWRESLRELELDLAEGADMVMVKPAGPYLDILARVADAVDVPVAAYQIS
                     GEYAMVEAAAEKGWIDRDQAIFETLTGIKRAGARNILTYWATEAAQKLR"
     gene            complement(17988..18704)
                     /locus_tag="S1361_RS22515"
                     /old_locus_tag="S1361_22485"
     CDS             complement(17988..18704)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674190.1"
                     /locus_tag="S1361_RS22515"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22485"
                     /product="DUF4232 domain-containing protein"
                     /protein_id="WP_208033606.1"
                     /transl_table=11
                     /translation="MRHIRLLAATGTAVTALALTACGTAGGTRDEGASRPTTPAASAEK
                     AASGKAAAETSQAATGGRTGNGRPVARTHAPDARPSASPTARGTRTGTAGGSVVLCNGA
                     NTTVTAQPLARPLNHLLITVKNTGGKTCELPYYPVLRFDQMQWVPQADRDTQPQAVVSL
                     APGESGYAGVLLSSADGSGTGGMTARKLTVGFQGLTPNSSGGPSATPSLPAKGVYYDSS
                     LKVTYWQQDLDAIAGW"
     misc_feature    18755..18769
                     /note="TFBS match to NrdR, Represses ribonucleotide
                     reductase encoding genes, confidence: weak, score: 20.63"
                     /tool="antismash"
     gene            18907..20295
                     /locus_tag="S1361_RS22520"
                     /old_locus_tag="S1361_22490"
     CDS             18907..20295
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674191.1"
                     /locus_tag="S1361_RS22520"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22490"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_208033607.1"
                     /transl_table=11
                     /translation="MPESGFAELLRELKNRSGHSYGTLAKRLHMSTSTLHRYCNGDAVP
                     ADYAPVERFARLCRATPGELVELHRRWVLADAWRGRKEPSPVTVTEPEPVAAAEPEPVA
                     APESEPEARAELVPVAESEPVAAAEPEPVPAPVAAAGPEPASEPVPAAPRRRSRRPAVL
                     LAALTVTALLGTAAVALNLPTGHPGDGKRDARDGKGTTATWEAAARDSASPAPTAASPA
                     PHRSAARPASPSPKASAARSGTPADGSGAAPPQRATTAPPLTVTTHPFSWESPCDQHYL
                     IDRPPTAVAPPPLEQDAPAWVDVHKAVSAGEQFVTFTVQGTGEQTVVLEKLSVRMAGKR
                     SPLAWNDYAMGYPDVGCGGGVPTHSFTVALDAMRPAPVPEAGSRDFPFKVSRSDPEVFY
                     VTADASAYDVSWYLELSWSSGDRHGTLLIDDAGRPFRTSGNNGRPAYAFPLGGEKWQPA
                     SEQH"
     gene            complement(20306..21103)
                     /locus_tag="S1361_RS22525"
                     /old_locus_tag="S1361_22495"
     CDS             complement(20306..21103)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674192.1"
                     /locus_tag="S1361_RS22525"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22495"
                     /product="DUF4253 domain-containing protein"
                     /protein_id="WP_208033608.1"
                     /transl_table=11
                     /translation="MATLPNPLPRLATDPSGRSLGLQLPPGRLVDETDDGSWHEPLLWL
                     ADKPAAPGTWKVLGAPARRAGLLPVLVDVGGAMAGPEQWELSPGLMSYPGDHDAEEVLA
                     EYWQEVAEDEAGVQPFGSSWPGLAGACSLAADPDTRAAQVADGLTDGARPRLKEPRLAL
                     VPARRSADIPAVIGWPGPLNYDSDVARLSAVLRSWEDRFGIRVTALGYDTLALSVAAPP
                     TSTAQAEAVAVEHFAFCPTDGTTTLRAYAEELVGATSWSFWWD"
     gene            complement(21210..21599)
                     /locus_tag="S1361_RS22530"
                     /old_locus_tag="S1361_22500"
     CDS             complement(21210..21599)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014674193.1"
                     /locus_tag="S1361_RS22530"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22500"
                     /product="VOC family protein"
                     /protein_id="WP_208033609.1"
                     /transl_table=11
                     /translation="MSTDTASAPVFRYAAVTFDCADPVELSRFYGEMFGLSVAYTSDEF
                     VFLGGKDGAPGLGFNRLADYRRPTWPDPAQEKQAHIEVGVDDLDESEAHLLALGATKPE
                     HQPQPDRWRVLLDPAGHPFCITTLV"
     gene            21672..22640
                     /locus_tag="S1361_RS22535"
                     /old_locus_tag="S1361_22505"
     CDS             21672..22640
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018568194.1"
                     /locus_tag="S1361_RS22535"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_22505"
                     /product="WYL domain-containing protein"
                     /protein_id="WP_208033610.1"
                     /transl_table=11
                     /translation="MLSASARLLRLLSLLAARPSWTCAELAGRMAVTDRTVRRDIARLR
                     ELGYTVDSEAGPWGGYRLRAGARVPPLILDDEEALAVAVGLRGAALGGALGGDQAALSA
                     LLKLRQVLPPRIAERLGEWDDALVRLPGSEGPQLRPGMLLELAAACRRGERARLSYRDG
                     QGRHTVRDVDPYRLVHAGRRWYFVARDTAHGWRTFRADRVERLQPTGHPVEIGDPPDPA
                     RLVSRNTAVGPYPLAATVRLPLPMADALRVVPATVGTHRADGPGATIVDIGGPDPDGLA
                     RYLLGLATPLCVLGPEAVREAYVRRVRELLAAQTADGPPPE"
     misc_feature    23051..23066
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.13"
                     /tool="antismash"
     misc_feature    23052..23066
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.06"
                     /tool="antismash"
ORIGIN
        1 gacctcgaaa agatcatcaa ggacaacggc gtctcgatcg gcgtgatcgc gacccccgcc
       61 ggtgccgccc agcaggtctg cgaccggctc gtggccgccg gtgtgacctc catcctgaac
      121 ttcgcgccca ccgtgctgtc cgtcccggac ggcgtggacg tgcgcaaggt cgacctctcg
      181 atcgaactcc agatcctcgc cttccacgag cagcgcaagg ccggtgagga gaccgccgcg
      241 ggcgacggcg cgctgcccgc caccacccgc gaggagtccg ccgaccaggg accggacggg
      301 gacgtccccg ccgtgatgcc ggcatgagcc tcctcgtcgt cggactgagc caccgcagcg
      361 caccggtcag cgtgctggag cgggccacgc tgagcgcgga cgcccaggtc aagctggtgc
      421 aggacacggt cgctgccgag cccgccaccg aggcagcggt actcgccacc tgcaaccgca
      481 tcgagctgta cgccgacgtg gacaagttcc acgccggtgt cgccgagctg tccacgctgc
      541 tcgcccggca cagcggcgtc ggcctggaag agctgactcc ctacctgtac gtgcactacg
      601 aggaccgggc cgtccaccac ctgttctcgg tggcctgcgg gctggactcg atggtcgtcg
      661 gcgaggggca gatcctcggc cagatcaagg actccctggc ccgtgcccag gacctgcact
      721 ccgccggcaa gctgctgaac gacctgttcc agcaggccct cagggtcggc aagcgcgccc
      781 actccgagac cggcatcgac cgcgccggcc agtccctggt caccttcggc ctggagcagc
      841 tggccgcggg cggggacgtc caggactggg cgagcggccg cacggcgctg gtcatcggcg
      901 cggggtcgat gtcgtccctg gccgccgcga ccctcgcccg cgccggggtc gccgaggtcg
      961 tcgtcgccaa ccgcaccttc gaccgcgccg agcggctcgc ccgaatcctc accgaggaag
     1021 gggacaccga ggtgaccgcc cgcgcggtgc ggatggacgc cgttgccgcc gagctgacac
     1081 gtgccgacgt cgtcgtctcc tgtaccgggg cgacgggtct ggtgctcacg gcggaggcgg
     1141 tcgcgcaggc ggtcgagggc cgcaccgggc ggcccgtcgc cgacaccggc gtcacggccg
     1201 tgcggcccgc gagcccgccg cggtccaccg gcgtcggggc cgacgagaac tgcccgctgg
     1261 acctggccgc cgtacagccc ggcttctccg tcatgggcga ggcggccgtg gccggcatgg
     1321 acgcggccac cctggagcag cacgcggcct gggtggacaa gggcacgacg gtggaccgcc
     1381 gggagcgccg tacgcccgag gcggacgccg agctgatcac cgcgctcgcc gcgaccgtgg
     1441 ccaccgtcgg ccggatcccc gagcggcgca agcccgagcc ggtcgccgag cggcccgcgc
     1501 ccagcttctt cctgctcgac ctcgccatgc cccgcgacat cgacgcggcc gtgcaccggc
     1561 tggccggggt ccgcctggtg gacatcgagt cgctcgcgga ggcctccgcc gacgcgccga
     1621 tggcggccga cgtcgaccag gtccggcgta tcgtctccga cgaggtcgcg gccttcggcg
     1681 cggcacagcg ggcggcgcac atcacgccga ccgtggtggc gctgcgcacc atggccgccg
     1741 acgtcgtcgc cagtgagatc gcccgcctcg acggccgcct gcccgacctg gacgaacgcc
     1801 agcgcggcga gatccgccag gccgtgcacc gggtcgtcga caagctgctg cacgcgccga
     1861 ccgtacgggt caagcaactc gcggccgagc ccggcggcgc ggggtacgcg gacgcgctgc
     1921 gcaccctgtt cgacctcgac cccgagacgg tcgccgccgt ctcccgggcc gtggacagca
     1981 cacagacgaa ggaccgaccg gcatgactga gaaggctttg aggctgggga ccaggcggag
     2041 caagctcgcc atggcccagt ccggccaggt ggcggaggcc gtccaccggg tgaccgggcg
     2101 gcccgtcgag ctggtcgaga tcaccacgta cggcgatgtc tcccgggagg cgctcgcgca
     2161 gatcggcggc accggcgtgt tcgtcacggc gctgcgcgac gcgctcctca ggggcgaggt
     2221 ggacttcgcg gttcattcgc tcaaggacct gccgaccgcg cagcccgagg aactggtcct
     2281 ggccgccgta ccggtgcgcg aggaccccag ggacgtgatc gtcgcgcggg acgcgctgaa
     2341 gttcaccgac ctgccgcgcg gggcgcgcat cggcaccggt gcgccgcgcc gcatggcgca
     2401 gctgaacgcg tacgcccgcg cccacggcct ggacatcgag acggtcccga tacggggcaa
     2461 cgtcgacacc cgcatcgggt acgtccgtga cggcgagctg gacgcggtcg tgctggccgc
     2521 cgccggcctc aaccggatcg gccggatcga cgaggcgacc gacttcctgt cggtcgacac
     2581 ggttctgccc gcccccggcc agggggcact ggcgatcgag tgtgccgcgg gcaacgcgga
     2641 actgatcgcc gcgctcggcg aactcgacga cccgttcacg cgggccgccg tgaccgccga
     2701 acggtcactg ctcgccgccc tggaggccgg ttgcagcgcc cctgtgggcg cgctggccga
     2761 ccttccccca ctctcggctc cgttcgagcg gggggacccc caggccgaca ggcagattgt
     2821 caaggaaatg cgcctgcgcg gcgtcgtcgg caccaccgac ggcacccgca tggtgcagct
     2881 gtccaccacc ggtcccgtgc cccagacgca cgaccaggcg tgggcactcg gtcgcgaact
     2941 cgccaccgag atgctcgccc agggcgcggc cggtctgatg ggggagcgag cacattgagc
     3001 cccaccgccc ttcctgccgc cggtccggaa cacgggcacg tcaccttcct cggtgccgga
     3061 cccggagatc cgggactgct gactctgcgc gccgtggagg cgctgtcgca cgcggacgtc
     3121 ctggtcgccg agcacgaggt gctcgacgtg atccggacgc acgcccgaca gggcgtctcc
     3181 gtggtgccga cggacgcgga ctcctcagcg gtgtccccgc cgggcacggg cacgccccag
     3241 ctgacggtcg ttgacggcac gtcaacaccc gccgctgtcc cggctgctgc ccgggatgcc
     3301 gctcatcttg tcatggaggc tgcgcggggc ggcaggcggg tggtccgtgc ggtgtccggg
     3361 gacccgggac ttgatacgta cgcggcggag gaaatgctcg cctgcgccgc cgccggggtg
     3421 cccttcgagg tcgtccccgg tgtcgcggcg gcggtcggcg tgcccgcgta cgccggtgtg
     3481 ccgctgcggg acgcgcaggg tgcggacgtc cggttcgtgg acgcccgtac ggcctcggac
     3541 cgctgctgga cggaggtcgg cgcctccgac ggcacggtcg tcgtgtccac caccctggac
     3601 tcggtggccg cggcggcggg cgaactggtc tcggcgggcc gcaagcccga caccccgctg
     3661 acggtgacgg tcgccggtac gacgacccgg cagcggacct ggaccgcgac cctcggcacg
     3721 atcgcccaga ccctgaagca ggcgaaggtg ctgccgtccc ccgacggcgg ccggccggtg
     3781 atagccgtgg tcggcgagcg cagcgccgcc gcccggcgcg accagctgtc gtggttcgag
     3841 tccaagccgc tgttcggctg gaaggtgctc gtgccgcgca cgaaggagca ggcggcatcg
     3901 ctctccgacc agctgcggtc ctacggtgcc gtgccgcacg aggtcccgac gatcgcggtg
     3961 gagcccccgc ggacgcccca gcagatggag cgggcggtca agggcctggt gacgggccgg
     4021 tacgagtgga tcgcgttcac ctccgtcaac gcggtgaagg cggtccggga gaagttcgag
     4081 gagtacggcc tggacgcccg cgccttcgcg ggcatcaagg tggccgcggt gggcgagcag
     4141 accgccaagg cgctgatcgc cttcggtgtg aagcccgacc tggtgccgag cggcgagcag
     4201 tcggcggccg gcctcctgga ggactggccc ccctacgacc cggtgttcga cccgatcgac
     4261 cgcgtcttcc tgccccgggc cgacatcgcc accgagaccc tggtcgccgg tctgatcgag
     4321 ctgggctggg aggtcgacga cgtcacggcc taccggaccg tgcgcgcgtc gccgccgccg
     4381 gcggagaccc gggaggcgat caagggcggc ggcttcgacg cggtcctctt cacctcgtcg
     4441 tccacggtcc ggaacctggt cggcatcgcg ggcaagccgc acaacgtgac ggtgatcgcg
     4501 tgcatcggcc cggccacggc caagacggcc gaggaacacg gtctgcgggt ggacgtgatg
     4561 gctccggagc cgtccgtgca caagctggcc gaggccctgg ccgacttcgg catgaagcga
     4621 cgggccgccg cgctggaggc gggggacccg gtgacccggc cgagcgagcg gcggccgggg
     4681 gcccggcggc ggcggaccac gacgtgaggg tacggccgta gcgcggctga cgagagacgg
     4741 agcgccccgt gcggggcgct ccgtctgttt tccgccgctt ttccgcggct gttgcgggag
     4801 tccggacggc ggaactagcc tggcatctgt ctaacagtgt tagtgaccgg cgtgtggccg
     4861 gcaccgacga agggggaccg gtgacgcttg aggcttccgc tccgatcggc ctgccgggcg
     4921 ggccgtacga cccgccgcac gcccggctgc tcgccctcgc ggccgccaag tgggcggccc
     4981 agcccatcgc ggtcctcgcc gaaatgggca tcgccgacgc cctggccgac ggcccgcgga
     5041 ccctggcgga cctggcggcc gccgtcgagg cccagccgtc cgcgttacgg cggtgcctgc
     5101 gcgcggcggc ctgtgtgggc gtcttcgccg agcaggagga cgggcgctgg agcctgaccc
     5161 cgatggcgga ctgtctgcgc cgcgacgcgg ccaccccgat ccgcaactgg gtgctcatgc
     5221 tcacccgggg tcccatgtgg gactccttcg gcaagctggc cgagaccgtg cgcaccggcc
     5281 ggtccgcctt cgaggtcgcc cacggcacgc cgttgttcga ctacctcgac aaggacgacg
     5341 cgttccgcga ggtctacgag tcggccatgg gcgagctgac cggtgaactc gcggcggagc
     5401 tggccgacgt cgtcgacttc ggccgctacg gcaccctggt cgacctcggc ggcggcgacg
     5461 gcgccctcct cgggaacctg ctcgcccggt acccggactg ccggggggtc ctggtcgagc
     5521 ggccccgggt gatcgaactc gcccgccctc ggctgaccgc gctcggggtc gccgaccggg
     5581 tccggctggt gcccggtgac gccaccgccg aggtgcccgc cggaggcgac gcctacctgg
     5641 tgaagaacat gctgcactgc ttcgacgacg acacggccct cgccgtgctg cgccgggtgc
     5701 gcgcggcggg cggcgcggac gccacgctct tcgtcgtcga ggcggtcgta ccgcccggca
     5761 acgacttcca ctgggccaag ctcatcgaca tcgagatgct cgccgacaac gacgggcgtg
     5821 agcgcaccga ggaggagtgg cgggagctgc tgcacgcggc cggattcgcc ctggaccgcg
     5881 tgtgcgccac caccccgccg cagtcggtgc tgatagcccg gccgctgccc ggctgatcgc
     5941 ccggccaccc ggtccggcat ccccgcacca ccgtccgatc cgacacgagg aggacccgtc
     6001 atgcgcgcac cctggaaggg cgaccccgtc gaacgcgccc gcaaccgtgc ccggcagcgc
     6061 gtgctgcagg agcagcagga cgccgagcag gcccgcaacc gcgaacgcca ggaacgacag
     6121 caggccgagc gggacgaacg ccagcggcgg cagcagtccc gctcggacga cgactgagac
     6181 ggcgtctgag aacgccgtcc gggacgagga ctgaccggcc cgcggctccc cggcgcgtcc
     6241 ggtggctccg ggccggctca gccggcgggg gagtcgccgg gcgccgccgc ggcgccgccc
     6301 gcgctgtcca ggcgggcccg aagaccgtcc aggaggcggt ccaggccgta gtcgaagcgg
     6361 gcctcgatgt cggggcgggc cagctggtcg ccgaccgcga cgacgttcgg gtactcctcc
     6421 gcgggcagct tcgcgagccg ctcccggacc tcctccagga actccatccg gtccgtgccg
     6481 cgggccacgt ccgccgacag cggggacgtc tcgtgcagca cgaaaccctg tacgtactgg
     6541 gtcagcacgt acagcgagta ggcggtgtcc tgcccgctga agcccgcccg gcgcagcggg
     6601 cccaggatga cctcggcgtg gtgcaggaag tgcggcccga gctggagccg gccggccagc
     6661 accttgcccg agtcccgctt gcccagcagg tacttgcggt aggcccgcat catgtcccgc
     6721 agctcggtct gccagtcgcc gtcctcgcgc accagcgggt ccagccgcag atcggccagg
     6781 agcgcgtcgg cgagcaggtc gagcagctcc tccttgttgc gcacgtacca gtacaaggac
     6841 ggtgcctgga tggacagttc gtcggcgagc cggcgcatcg acagtgcttc cagcccgtcg
     6901 cgctggagag tgcgcagcgc ggcggcggtg acggcgtcga gcgtgatcga cggacgggag
     6961 gcccgtccgg ccgtgcgtcc ggcgcgctga cctgccatgc gccgactccc tcctgtgcgg
     7021 cccggaacgg gccgagcgcc ctgtgctgac gcctctcgtg cgtccctaat aatgttagag
     7081 aatggtagag gacgcggttg gcggaaagtc gacggaagtc cgcggcgtca ccgcagatgc
     7141 gggaggacct cctcggtgaa cagacggaag ctgcgttcca tcgtcggccc gtcctgcccg
     7201 ccgaagtcca cctgccacag gaaggtgtcg acggacagga actccttcag ccgccgggct
     7261 cgttcgagta cggtcgccgg cgagccgacg acggccgtgc cgaggctgcg gaagtcggcg
     7321 atgtcgaggt tgcgcagcgt cagcgccatc tgcgagtacg tcgggtagtc cttggacgag
     7381 gtgttcatcc aggcctcggc ggcctccgcc cacaccgcca ggtactcccg cagcagcggg
     7441 tcggcgaccc ggtacgcctc gtcgtcggtc tccgccacgt acagcgggat cgacaccgcg
     7501 acccgcgggc gtggggcgcc gggggcgtcg ccgtgcacat ccgcgaaggt gtccaggtag
     7561 acgtccacca ggtcccgcac gcccgcgagg tcctcgctgc gcggcggcgg ggtcaccagc
     7621 agtccgaacc cctgctcggc gagccaggcg aagctctgcc gggagcgcac cgcggcaccc
     7681 cacacgggcg ggtgcggccg ctgcacgggc gccggcaggg aggtgacctc gcggaaggag
     7741 aagaacgggc tgtcgacggt gaccttctcc tcggtccaca ggcgccgtac ggcggcgatg
     7801 gtgtcggtga accggtcccg gctctcgtcc atcgggacgc cgaacgcggc gaactcgtac
     7861 ggcagccagg cccgggcgaa ccccacctcc agccggccgc cgctgagcgc gtccaccatg
     7921 ccggtgtgcg cggcgatttg gatcgggtgg tggaaggcgg gcaggacgca tccggtcatc
     7981 agccggatcc gcgaggtctg cgcggccacc gcggcgagga aggtcagcgg actgggacag
     8041 tagccgccgt actccttcag gtagtgctcg gtgatcttga cgtagtccag accggcctcg
     8101 tccgcgagcc gggacaggcg caggacgtcg gtgtagtact cctgggccgg gcgggtggcg
     8161 gggcggcagt cgggcagcag tgagatgccg tgtttcacgg tcggcggctc ctctcggtcg
     8221 gtatcagcag ggcgaggtag gcggcgtcgg cggtcagcag gggcgccacc gagccggtgc
     8281 gccagaacag agcggcgtgc acggctggga ccagcacggc gggcacccag gtctccggcg
     8341 cccggcgccg tccggccggg gcgtcgcgca gccgtacggc cgtgtgggcg gcggcggccg
     8401 cggtcacggc ggtcacggca ccggcgccgg cgagggcggg gacgagtgcg gcccggaagg
     8461 acagctcgtc gcacaccgcg accgcgacca gcacgccggc accccaccac gggacggccc
     8521 gcacggaggc ccgcgcctcc tcggccgcgt gtccccgggc gagccccagc cagtgcgtgc
     8581 ggccgacggc actggcgggc cggcgctccg cggcccgtgc cgtcaccgca ccggcgggcc
     8641 ggcggtccac ggtccgtgcc gctgccgcgc cggcgggccg cagccgcgcc gggcgaccgc
     8701 ccggccggtc cccgtgcgca cggccggcgc ggtccgcggg gccacggccg gcggagaaag
     8761 agggcgtttc gaggcgacgg ccccgccgcc cgcccgtccg ggcgacgccc gcgccgagac
     8821 gtgccagggc cgtcccggcg cccgcgccga ggcgtgtcag gatcgtcgtg acgcccgcgc
     8881 cgagccgtcc cgcgagggtc gccagccgtg tcccgcgcag tgcgtccgcg gtgtccgccg
     8941 ccacgctcgc cgcgaaggcc gcggtggcga actcgccgca ccccagggcg atcccggagg
     9001 cggcgagggc gaggccggtg ccgttcggca gggccgacgg cgggcgcagc aggcccagac
     9061 agacggccgc gacgaggacg gcgcacccgg cggcgcagcc ggcggcggcc cgggcgagcg
     9121 gatgcggcca ggagcgccgg ccaggtgccc agcggcgccg cagccgggtg aggcagggga
     9181 caaggacgcc gtacgcaccc gccgtcacca ccgccaggac ccctgccgtg accgccccgc
     9241 tcacggcgtc accgcccggc tcccggcgga gcgcacggtg ttctggtagc gccagatccg
     9301 caggttgaac agggcgtgca cggtgatcgc gccgaggacg tcaccggtgg ccagggtgag
     9361 ggcgaggccg gcgagtgcca gcgggagctt cgccgccacc tgggtccagc cgaagaacag
     9421 gtgggacagc gcgaaggcgg ccgtggccag tgtgaggacc gcgatccgca cggcccatcc
     9481 ggtcagggcc atggcctccc cggtgagcac cccgcggaac acgcactcct ccagtgcccc
     9541 cacggccacc agccaccccg gtggcagcgc cacgtcggtg tcgcggtggc tgggagtcca
     9601 ccgccgctcg gtggtgccgg ccgtccgggc accggcgacc cgcgcggcca ggcccaccgc
     9661 ccgggtggtc cggacggccc ggggcggtcc ggccggtggc gcggaccggg cggcgcggcg
     9721 cccgagccgc cgggtgatcg ccgtgtcggc ggccgccacc ggcgccgcga gcacggctcc
     9781 ggcgagcggt ccggcggcca gcccccagac gggcccccgg tacagcgccg ccggcccgag
     9841 gaccagcagc ccgtagccgg tgaccacggc gagcacagcc gcgtacacgt gcagggtgtg
     9901 cacgccccgc cggtcgagga accgcacgtg caggtgggag gcgagcgcca ggctcgacag
     9961 cgcgcacagc gccagcgcca ccgccgacgc cgcacgcagc tcagggatat ggatgaggga
    10021 cgtcatcggt gaagcccccg tagtcggcga accggggatg ggcggccggt acggcgctgg
    10081 gcagcggcag gctcacggtg tccggcgacc acacgcgcat cgcgtggaaa ccgagcgcgc
    10141 gcaggtcacg ggtggtcaga tcgccgaagt agagccgctt gcccgaggag gcgaaggcgt
    10201 cgacgagggt gcggaccgcc tcccggacct cgcggtcgtc gtcgggcggc agctgggacg
    10261 ccggctgctc ggtgtgccgg gcgaagcgtt cctccacgat ccgcgcgccc tcttcggtgg
    10321 cgtaccggcc gacgttgccc tccaggtcgt agatcgcctc gtccggtgcg gcgcccgtca
    10381 ccgcctgttc cacggcgacc caggcggcga gccactgcac gcccgccgcc tccagcagcg
    10441 cccggtacat cgcccggggc agcgaggcgc cgctgcccag gccgatggcg gtgcgcggga
    10501 cgagtccgga cggctggcgc agcaggcagg cgatggtgaa gccgggcagg tcggggctgg
    10561 gcaggaggtg gaactccggc cggggcgcgg agtccgggaa gtaggtgtcc accagggcgt
    10621 cgaggtgccg ggtgcgggcg tcgggacgga tcagcacgct ctcggtacgg ccgtaccagt
    10681 ggcccatcgc cgcgtccacc tgcaccacct cttccagcgc cgcgcgcagc gcggcctgcg
    10741 gggtggtgtg ggtggcggtg ccggtggtga ccgccggcag cgtccagggc tcgtcggcct
    10801 cgcggacgta gccgagcagg aaccgttgcg cgggcaccca gcacggtccg tcgccggtca
    10861 gggagtcgac gagcagccag ccgaagggcg cgtcggtgtg gaacggctgg aacgggaaac
    10921 cctcgcgggc gtactgctcc tcggtgaaga gccggaacgc ggactccggc aggaccggtt
    10981 cacccgcctg cgcgagcgcg gtgcggctgg tgtgccgctg tgtgaagcgg ccgtcgagcg
    11041 cggcggcgta gcccgcgtag cgctccaggg tctcggcgag ggaacggatg tggctttcga
    11101 acggaaagat gccgtagccg ccgatgtggt agctgccggc cttcggtgcc ggctggttct
    11161 ggcggacgtg cacgccggtc atgtcggcgg tgccgaccag cagccggggg ccgtccgggt
    11221 agcgggtgag gaaccccatg gaggtggtca ggccgcagag cgggccgtgc atccgctcgc
    11281 gcagccggtg gacgcgcacc tcctcgtcct ggtggaggcg gagccgcatc agtcctccag
    11341 ccaggtgcgc gggtcgaagt gcagcgtctg gtcgtcccgt tcgggtacgg caccgcagcc
    11401 ggggcagccg ggcagcggca ggacctcctg gtaggagagt tccatgctcg gcagatagca
    11461 gccgaggacc ttctcgacgg tgaacgtggt gccgcaggcg aggtagttgg tggcctccat
    11521 cgccaggtgc gagcagagca gcgaggccac cggaccgtac aggggcggct cgccggccag
    11581 cacggcggag cgcgcgaggg cctccttgta gcgctggtag gaggcgctct cgcggaggtt
    11641 catcgtcacg cgggtctcga agcactcgaa gcaggacgag cgtccggcga tcatcgtggg
    11701 gccgacgaac aggaacggtc cgtcgatggc cgcgtacgtc cagctgatcc cggccgcgcg
    11761 ggtcagccgg ttgaggagct gggcgcggac cgggtcgatg gtccgctcgg ccagcagaag
    11821 gtgccggccg gcccaggggc gcaagacctc ggcggcctca ccgaaggcca gcccgtcgtg
    11881 cagcacggac ggcggcaggc tctccagacg cgcgcgcacc gggtggtcgg ggccgggtat
    11941 ccggatgtcc ggggcgagtt cggcgggcag cagggcggcc gtgcgctcgc acagctcggc
    12001 gtcgccgagc aggacgacgc cctcggcggc cggccgctcg ccgggcccgc ccagggcggc
    12061 catgtcgtcc aggtaggcgt ccagggcgct gcgcggctcc tcctcgatcg cgtcgagccc
    12121 gtagaggtgg tcgaccaggg cctccacctc gacccgcgag acgccctcgc gcttggccag
    12181 gtcgcgccgt gagagggtcc cgtcgaggcc gctgaccagg ttgaacagct tgccggagcg
    12241 ggagtcgtcg gtgagtgtgt aggagcgggc gttccacacg ccggtgcgca gttccacgac
    12301 gtccgggctg tggccgatga ccgagaaggt acggcgcacg cgcggctgcc ggttgtcaga
    12361 cattcgggga gagcctctct gttacgggtg gtccggtgag gcgtacggag tcagggggcg
    12421 ggccgggccg tggctcagcc ggcgccgagc aggaccgtgt gcagcagcac gcggtgggtg
    12481 ccgtccaggc ccatcgcctc gtgcgcctcg tcgtcgtaga aaccggagaa gtccacgctg
    12541 cgcaggccga gcgccgtggc cgccaggtgg gtgttctgcg cgatgccgcc ggcctcgtgg
    12601 aacatcgacc gcatgccgcg cggcccgtac ttgcgcatcg cgcgccaggg ggtgccgacc
    12661 agcaggacga tcgccgcggc gcgctcgaag tcgatctggc cgtcctgcgg gtcgaaggag
    12721 gcgaggagcg aggtcagggc gtcggggccg gcccggcggg cgagggcgtc ctccacgggc
    12781 aggtagcggt gcagtccggg ctccagcccg tcgacccgca gggccgccag ccacagctcg
    12841 accgggtaca ggccgccggc gctgggcacg gcacggaagc ccatggtcag cggggtgccg
    12901 tcggtcagtt cgaggtcggc ctcggcggtg accgaaccgg ccagcctgac cacggtggcc
    12961 agctcgtcca gagggagcgg cgcgccggtg aagtcacggt cgctgcgccg ctgaaggatc
    13021 gtttcgacca ggccggccga cggctgcgcg ccctcgggca gcgcggtccg tggcgcgcca
    13081 cgtcggggga gccggtcctg acgggactgc acgaccgcca tcacatcgga gaagtaatag
    13141 ccgatcgaga gcagggaagc gcggtcccac cgccgcattc tggtggccag gaggaattct
    13201 tcggcaatcc ggcgaaagcg tccggacgag aggttttcaa aacgcattga atgcgtttgc
    13261 agggcgactc cgtcgacctg tgggctcagt gtacggtagg cgctcgcggc caccgacgcc
    13321 tgaatgaccc gtgcattatt cggagggcct gcctcaccca tgtacgctcc ttgcgtcaag
    13381 gggccggccc gccgtggctc ccggtgcgcc ggaagctcgg cgggccggcc gggctcactt
    13441 acttgcggac gacggcgccg cagcagcagg aacaggcgcc gggcaccaga acggcctcgt
    13501 cgcgaccggc cccgaagggc tcgagcgcgg cctgcggggt gctgttgcgg tgttcggtga
    13561 ccttctcgga ctgcagcttc acggcagcct cctttcgctg gatcgggata gtgaggaatg
    13621 cattccggtg agctcggcgg gcccattctc cgaggctcac gaggacgcaa cctaacacca
    13681 ttcgaggaaa gctcacaagg gtaaacagtc gtcaagtaaa ggcaaaaagc aagagactgg
    13741 attccgtttt gcgcagggat ccagccagat tatttcaggg gtattgcggg accgggttcc
    13801 cgctgttagc aaggctccat gaccgtcgaa gacaacgccc cggtcgacct gctcgacccg
    13861 gcattcatgg ccgacccggg cccggcctac gagcggctgc gcagcacggc ccccgtcacc
    13921 cggatccggt tacggccggg cctgtccccg tggctgatca gcggctacga ggaggcgcgc
    13981 accgtcctgt ccgacccggt gttcagcgtg gacccggccc gcacccggcc cggcgtgcgc
    14041 gaggcgatcg cggccggccg cgccgaggag aagacggcgc tgctcggccg gcacctgctg
    14101 agcgtggacc cgcccgacca cacccggatg cgccggctga tgtcccgggc cctgaccgcc
    14161 cgccggatgc agcagctgcg ggggccggtc ggcaccttcg ccacggagct gctggacgca
    14221 ctgaccggac gtcgggagtt cgacgtcctg ggcgactacg ccctgcccct ggccgtgcgg
    14281 gtgatctgcg aactcatcgg catcccgccc gaggaccggg ccgccttcca gcgctgggga
    14341 agcctgctgg tccgctccga gctgcaggac gacgcctcct tcgaccgggt ctccgacgag
    14401 atggccggat acctcgtccc gctggtcgcc gcccgccggg ccgaacccgc cgacgacctg
    14461 gtcagcgcgc tggtcgccgc ccacgacgag gagcggctgg acgactacga gctgatctcc
    14521 ctcgtctacc agctgttctt cgccggccat gagtccagcg cctacctgat cgccaacgcc
    14581 accctgcggc tgctcgccca ccccgacgag cgggccgcac tcgcccgcga gccggagcgg
    14641 atcgagtcgc tgatcgagga ggtgctgcgc atcgacgggc cggtcaaggt gcccacctgg
    14701 cgcttcccgg tccgggacgt cgatctggcc ggggtgcgcc tgcgggcggg cgagccggtc
    14761 ctcgtcctgc tcggcgcggc cggccgcgac ccccgtcgct tccccgaccc cgaccgcttc
    14821 gacaccgggc ggacagccgt ccagcagcac ctcgccttca gccacggcat ccaccactgc
    14881 atgggcgcgg ccgtcggccg tatggagggc caggtcgccg tcggccggct gttccagcgc
    14941 ttcccggagc tgcgtctggc cgtaccgccg gagcgactgc gctggcggga caacctgatg
    15001 atgcgcgggg tctgcgagct gcccgtccgg gtggggtgag ggacgggacg cgcggtgcat
    15061 gaacagggcc ttgcgaagcc gggcgccgga cggatcccgc tgacggggga ttccagacga
    15121 gatccgcccg gcagtctcat gaggtgcggt cggcggggct cttctcgcgc gccggggcgg
    15181 ccgcgggatc ggtgtcgacg tcgtcccggt cacgcccgcg caccagcagg aacaccacca
    15241 ccgccgtgac cagcagcagg gccgcgccca cccgctccgc caggtgcagg ccgtccacga
    15301 acgccgcgtt caccagggcg ccgatccgcc ggtccccgcc gccgccggcg ctctgcgcac
    15361 cgccggccgc caccgcacgt acgacctcgt cgcgcacctc cgccgggacg tgggcgtcgg
    15421 tgaggcggtc gcggacgccg tccgtcatcc gggtcgtcag cagcgtgccg aggacggcca
    15481 ccccgaagac gctgcccagc tgccgggtcg cgttgctcgc gccggacgcc atgccggagc
    15541 ggttcgccgg gacccgcatc atcaccagcg tggagatcgg cgtgagggtc agcccgatac
    15601 cgaggcccac cagcaggacg acccaccagt acgacgagta gtgcgcaccg acgccgtaca
    15661 gcgaggcccc gaacatcgtc agcgccgagc acaggatgcc cagcgtcagc ggcacggcgc
    15721 cgcccatccg cccggtcatc cagcccgcgg gcggcgccgc gaccatggcc agcagcatgc
    15781 ccggcaggat ggcgaggccg gcgcccacgg cggaccagcc gaggaccgtc tggagccaga
    15841 gcatcaggaa gtaggtgatg gcgaacaggc cgaagtagag aacgaatccg gccagcaccg
    15901 cgccggtgaa gacgggatcg cggaagaacg acaggtcgag catcggttcg cgcaccagct
    15961 tctcggtgac cacgaacgcc accaggagca ctccgcccgc gacgaacgca ccgatcacca
    16021 gccggtcgct ccagccgcgt gaaccgccct cgatcgtggc gtacaccagc gccgccacgg
    16081 ccgccacgga cagcaccaga ccggccaggt ccaggcgccg ctcgggactg gccgactccg
    16141 gcaccgtcca catgcccagc agcaggccga tcacggcgac ggggacgtac atccagaaga
    16201 tgcccgccca gccgaagttc tccaccagtg gtccgcccgc caccggcccg aaggcgacgg
    16261 ccgcgccggc gacggcggcc cagatgccga tcgcggtgcc acgctcgccg ctgtcggtga
    16321 agacgtgcct gatgatcgac agcgtgttgg gcatcagcag ggccgcgccc accccgagca
    16381 cggcctgccc ggccacgagc acccacacgg acccggcgag cgcggagaag accgagcccg
    16441 cgaggaacac cgcgaggccg gtgaggaagg tccgcttgcg tccgaagcgg tcgccgcacg
    16501 cgccgcccgt cagcatcagc gcggcgaacg ccagcgaata gccgctgatg acccactgga
    16561 tgtcctggat gccgccgctc aggtcgtcct ggatgtccgg taacgccgtg ctgagcaccg
    16621 tggactggag catcgtcagc gccagcggga cgcacagtgc cggcagcgtg cggtaggggc
    16681 tgggaccggt cggggcgggt gtgtccgccg tcatcgtgca ccgtcctgtc gtcgcgttct
    16741 ccggctgccg cacagccggc tgtctaacac cgttagagag actctaacac cgtaaggcgg
    16801 gacggggaag gcgcacgcgg ggcgcacgga cggcaagggg cgccccggga tgcgcggagc
    16861 gcgaagagtg gggaggggtg cgaaagaggg gagcgcgaag agggggacgg tgcgcgggag
    16921 gggagggccc gcgtcgacag ggcgtcggca aaggagcagg ccgggcgggc gtagcgtaga
    16981 gggcatgacg aagtacggat cctttcccgg tacgcgtccg aggcggctgc ggacctcgcc
    17041 cgtcatgcgc cgcatggtcg ccgagacccg gctgaacccc gccgacttca tcctcccggc
    17101 gttcgtccgg gaaggcgtca gtgagccggt gccgatcggg gcgatgcccg gggtcgtgca
    17161 gcacacccgg gacagcctga agaaggccgc gctggaggcc gttcaggccg gggtctccgg
    17221 gatcatgctg ttcggcgtgc cggaggacgg gaagaaggac gcccggggca cggccggcac
    17281 cgacccggac gggatcctcc agctcgccct gcgggacgtc cgcgccgagg tcggcgacga
    17341 cctgctcgtc atgtccgacc tgtgcctgga cgagttcacc gaccacgggc actgcggggt
    17401 cctggacgcc gagggccgtg tcgacaacga cgccaccctg gagcggtacg ccgagatggc
    17461 gcaggtgcag gccgacgccg gcgcccacgt cgtcgggccg agcggcatga tggacggcca
    17521 gatcggcgtc atccgcgacg cgctcgacca gatcggccgc gaggacgtcg cgatcctcgc
    17581 ctacaccgtc aagtactcct ccgccttctt cggccccttc cgcgaggccg tcgcctcctc
    17641 cctccagggc gaccgcaaga cgtaccagca ggaccccgcc aactggcgcg agtccctgcg
    17701 ggagctggag ctggacctgg ccgagggcgc cgacatggtc atggtcaagc cggccggccc
    17761 ctacctcgac atcctcgccc gggtcgcgga cgccgtggac gtgcccgtcg ccgcctacca
    17821 gatctccggc gagtacgcga tggtagaggc cgccgccgag aagggctgga tcgaccggga
    17881 ccaggcgatc ttcgagaccc tcaccggtat caagcgggcc ggggcccgga acatcctcac
    17941 ctactgggcc accgaggcgg cccagaagct gcgctagccg cgagccgtca ccagccggcg
    18001 atggcgtcca ggtcctgctg ccagtaggtc accttcagcg agctgtcgta gtagacgccc
    18061 ttggccggca gggacggggt cgcggacggg ccgccgctgc tgttcggggt gaggccctgg
    18121 aagcccaccg tcagcttgcg ggccgtcatc ccgccggtgc cgctgccgtc ggcggacgac
    18181 agcagcacgc ccgcgtaccc cgactcgccg ggcgccaggg agaccacggc ctgcggctgg
    18241 gtgtcccggt ccgcctgcgg cacccactgc atctggtcga agcggagcac ggggtagtac
    18301 ggcagctcgc acgtcttgcc gccggtgttc ttcacggtga tcagcaggtg gttgaggggc
    18361 cgggcgagcg gctgcgcggt gacggttgtg ttcgcgccgt tgcacagcac cacggagccg
    18421 ccggcggtgc cggtgcgggt gccgcgcgcg gtgggggagg cgctcggccg cgcgtcgggt
    18481 gcgtgggtgc gggccacggg cctgccgttc cccgtacggc cgccggtggc ggcctgggac
    18541 gtctccgccg cggccttccc cgacgcggcc ttctccgccg acgccgccgg ggtcgtcggc
    18601 cgggaggcgc cctcgtccct ggtgccgccc gcggtgccgc acgccgtgag cgcgagggcg
    18661 gtgacggcgg tgccggtggc ggcgagcaga cggatatggc gcattcgcat ggcaagtcct
    18721 ctttcgggct gggccggttg gcgtgcttgg atgaccacag cctgtgggcg gggccgtccc
    18781 ggcggccagc agcggccgcg gatccgggac gctggaacgc tcacaccggc tttgacctgc
    18841 gggaacagtc cctccctgga acgccggggt gggacgaggg ggaacggaga aacggtgtcg
    18901 gaaggcatgc ccgaaagcgg cttcgcggag ctgctgcggg agttgaagaa ccgctccggg
    18961 cacagctacg gcacgctcgc caagcggctg cacatgagta cgtcgacgct ccaccggtac
    19021 tgcaacgggg acgccgtacc ggcggactac gcaccggtgg agcggttcgc ccggctgtgc
    19081 agggccacgc ccggggaact cgtggagctg caccggcggt gggtgctggc ggacgcgtgg
    19141 cgcgggcgga aggagccgtc gccggtgacg gtgaccgaac ccgaaccggt ggccgcggcg
    19201 gaacccgagc cggtggccgc gcccgagtcc gagcccgagg cccgggccga gctggtgccc
    19261 gtggccgagt ccgagccggt ggccgcggcg gaacccgagc cggtgccggc cccggtggcc
    19321 gcagccggac ccgagccggc gtcggagccg gtgccggccg cgccccggcg ccggagtcgc
    19381 cgccccgccg tcctcctcgc cgccctgacc gtcaccgcgc tgctcggcac cgctgcggtc
    19441 gcgctgaacc tgcccaccgg gcaccccggc gacggaaagc gggacgcccg ggacggcaag
    19501 ggcaccacgg ccacctggga ggccgccgcc cgggacagcg cgtcgccggc gccgacggcc
    19561 gcgagcccgg cgccgcaccg gtccgccgcc cgcccggcct cgccctcacc caaggcctcc
    19621 gccgcccgca gcggcacccc ggcggacggc tcgggtgccg ccccgcccca gcgggcgacg
    19681 accgccccgc ccctcacggt caccacgcac cccttcagct gggagagccc ctgcgaccag
    19741 cactacctga tcgaccggcc gcccaccgcc gtcgccccgc cgccgctgga acaggacgca
    19801 cccgcctggg tggacgtgca caaggcggtc tcggcggggg agcagttcgt caccttcacc
    19861 gtgcagggca ccggtgagca gaccgtcgtc ctggagaagc tgtccgtgcg catggcgggc
    19921 aagcggtcac cgctcgcctg gaacgactac gccatgggct atcccgacgt cggctgcggc
    19981 ggcggtgtgc cgacccactc cttcaccgtc gccctggacg cgatgcgccc cgcccccgta
    20041 ccggaggcgg ggagccggga cttcccgttc aaggtgagcc ggtcggaccc ggaggtcttc
    20101 tacgtcacgg ccgacgcgtc cgcgtacgac gtcagctggt acctggagtt gtcctggtcc
    20161 agcggggacc ggcacggcac actgctgatc gacgacgccg gccggccgtt ccgcaccagc
    20221 ggcaacaacg gccgtccggc gtacgccttc cccctcggcg gcgagaagtg gcaaccggcg
    20281 tcggagcagc actgaccctt ccggctcagt cccaccagaa ggaccaactc gtggcgccga
    20341 ccagctcctc ggcgtacgcc cgcaacgtgg tggtgccgtc cgtcgggcag aacgcgaagt
    20401 gctccaccgc caccgcctcg gcctgagccg tgctggtcgg cggagccgcg accgacaggg
    20461 ccagtgtgtc gtagccgagc gccgtgaccc gtatgccgaa gcggtcctcc caggagcgca
    20521 gcaccgcact cagccgggcc acgtcgctgt cgtagttcag cggccccggc cacccgatca
    20581 ccgccggtat gtcggcggac ctgcgggccg ggaccagcgc gagacgcggc tccttcagcc
    20641 gaggccgcgc accgtccgtc agcccgtccg ccacctgggc ggcccgggtg tccggatcgg
    20701 cggcgaggga acaggcgccg gccagccccg gccaactgct cccgaagggc tgcacacccg
    20761 cctcgtcctc cgcgacctcc tgccagtact ccgcgaggac ctcctcggcg tcgtggtccc
    20821 cggggtacga catgagcccc ggactcagct cccactgctc gggcccggcc atggccccgc
    20881 ccacgtcgac gagcaccggc aacagccccg cacgtctggc cggggcgccg agcaccttcc
    20941 aggtgcccgg cgcggcgggc ttgtccgcca gccacagcaa gggctcgtgc caggagccgt
    21001 cgtccgtttc gtccaccagc ctgccgggcg gcagttgcag ccccagggaa cgtccactgg
    21061 gatcggtggc cagcctgggc agcgggttgg gaagagtcgc cataccgatg actgtagggc
    21121 cggccactga caacgccctt gacccgcttg gccggtggag gcgcgaccgt gccggagggg
    21181 gcgtcccgtg cgcagtgtcc ggcccggtct cagaccagcg tcgtgatgca gaacggatgc
    21241 cccgccgggt ccagcagcac ccgccaccgg tccggctgcg gctggtgctc cggcttggtc
    21301 gcgcccaggg cgagcaggtg ggcctcggac tcgtccaggt cgtccacgcc cacctcgatg
    21361 tgggcctgct tctcctgggc cggatccggc caggtggggc ggcggtagtc ggccaggcgg
    21421 ttgaagccca ggcccggcgc gccgtccttg ccgcccagga acacgaactc gtcggaggtg
    21481 taggcgacgg acaggccgaa catctcgccg tagaaacggg acagttcgac cggatcggcg
    21541 cagtcgaagg tgacggcggc gtagcggaag acgggtgcgg aagcggtgtc tgtgctcatg
    21601 aggacgaccg taggacgcaa cccggacagg tacggtcctg gtcgtgccgg cccgtgtgaa
    21661 aaacttccgc cgtgctcagc gcctccgccc gcctgctgcg cctgctctcg ctgctcgccg
    21721 cccggccctc ctggacctgc gccgaactgg ccggccggat ggccgtcacc gaccgcaccg
    21781 tgcggcggga catcgccagg ctgcgggaac tcggctacac cgtcgactcc gaggccggac
    21841 cctggggtgg ttaccggctg agggccggtg cacgcgtccc gcccctgatc ctggacgacg
    21901 aggaggcgct cgccgtggcc gtggggctgc gcggggccgc gctcggcgga gccctcggcg
    21961 gggaccaggc cgcgctgtcg gcgctgctca agctgcgcca ggtgctgccg ccccggatcg
    22021 ccgagcggct cggggagtgg gacgacgccc tggtacggct gcccgggtcc gaagggccgc
    22081 agctgcggcc cggcatgctg ctggagctgg ccgccgcctg ccggcggggc gagcgcgccc
    22141 ggctgtcgta ccgcgacggg cagggccggc acacggtccg ggacgtcgat ccgtaccggc
    22201 tcgtccacgc cggacggcgc tggtacttcg tcgcccggga cacggcacac gggtggcgga
    22261 cgttccgggc cgaccgcgtc gagcggctcc agcccaccgg gcacccggtg gagatcggtg
    22321 atcccccgga tcccgcccgg ctcgtctcgc gcaacaccgc cgtcggcccc tacccgctgg
    22381 ccgccaccgt tcggctcccg ctgcccatgg cggacgcgct gcgcgtcgta cccgccaccg
    22441 tcggcaccca ccgcgccgac gggcccggcg ccacgatcgt ggacatcggc ggccccgacc
    22501 cggacggact cgcccgctac ctgctgggcc tcgccactcc gttgtgcgtc ctcggcccgg
    22561 aggcggtacg ggaggcctac gtgcgccgcg tgcgggaact cctggccgcg cagacggccg
    22621 acggcccgcc cccggagtga gggcgggccg tcggcgtcgt gcgggcgcgc tcggtcagag
    22681 cttctcgggc gtgcggatgc ccagcagggc catcccctgg tgcagggtgc gggccgtgac
    22741 gtcgcacagg aagaggcggt tctccacctg cgccggggtc tcggcgcgca gcaccgggca
    22801 cttgtcgtag aacgacgtgt acagggacgc cagctggtac aggtacgccg ccagcttgtg
    22861 cggggcgtac tccgccgccg cctcccggac cgtctccgcg aaggagtcca ggtgcaggcc
    22921 gagggcgcgc tcggcgtcgg ccagggccag ctccgggtgg gccgccgggg agacctcgcc
    22981 ggccttgcgg aggatggacc ggatacgggc gtaggcgtac tggaggtaga cggacgtgtc
    23041 gccgttcagc gagaccatct ggtccaggtc gaacttgtag tcccggttcg ccgacgtcga
    23101 caggtccgcg tacttcaccg cgccgatgcc cacctgggcg ccccgctcgg cgatctcctc
    23161 ctcggacagg tcctgcgc
//
