LOCUS       NZ_CP071839            20993 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3179302
            Orig. end                         :: 3200295
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..20993
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="terpene"
                     /region_number="11"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /tool="antismash"
     cand_cluster    1..20993
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20993
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="False"
                     /core_location="[10000:10993](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10993
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     misc_feature    complement(71..87)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.48"
                     /tool="antismash"
     misc_feature    complement(671..680)
                     /note="TFBS match to AbrC3, Antibiotic production
                     activator, confidence: strong, score: 18.07"
                     /tool="antismash"
     gene            complement(1105..2730)
                     /locus_tag="S1361_RS14260"
                     /old_locus_tag="S1361_14240"
     CDS             complement(1105..2730)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007495110.1"
                     /locus_tag="S1361_RS14260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14240"
                     /product="MFS transporter"
                     /protein_id="WP_208032224.1"
                     /transl_table=11
                     /translation="MTPGTGAADSSAGARSVLWTLAAGQFLMALDSSVMNVSIATVADD
                     VGTTVTGIQGAITAYTLVMAMFMIPGGKVGALIGRRRAFMIGCCIYAGGSLTTALAPNL
                     PVLLLGWSFLEGIGAALILPAIVALVAGNFTAERRPAAYGLVAAAGAVAIALGPLIGGF
                     ATTYLSWRWVFAGEVLVVIGILAFARRIADVVGGKRPHLDLIGTLLCALGLGLFVYGVL
                     RSDEWGWFRPKPHAPAWLGFSLVVWLMLAGLLLVWLFLRWQVRLVQRHREPLIDPALLQ
                     NKQLTGGLTMFFFQYLVLMGVFFVVPLYLSVALGLSALRTGAWLLPLSLTMLAAATLIP
                     RFFPDVSPRRVVRLGILALLAGAVALMAALDAGAGAEIVTVPLLLVGLGMGALASQLGS
                     VTVSSVPDEQSAEVGGIQNAATNLGSSMGAALAGSILIAVLASSFLTSVEQNPAIPAEV
                     KSQAAVELQSGVTFLSDAGLKAALDAAGTNEEVARAALKANADARLAGLRAALAILAFA
                     SVLALFFTSRIPRTQPRSTQSRSA"
     misc_feature    complement(2792..2806)
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: strong, score: 19.37"
                     /tool="antismash"
     gene            complement(3055..4350)
                     /locus_tag="S1361_RS14265"
                     /old_locus_tag="S1361_14245"
     CDS             complement(3055..4350)
                     /EC_number="1.11.1.-"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010474993.1"
                     /locus_tag="S1361_RS14265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14245"
                     /product="vanadium-dependent haloperoxidase"
                     /protein_id="WP_208032225.1"
                     /transl_table=11
                     /translation="MTLTAATSPPDTDTRTAADPAAVVREWNAIATDTITTSLGPRPSG
                     QAAIWEGFVSVAVYNAVVGIEGRYALYKWHERGPAKASSAAAAATAAHDVLLTYFPAFK
                     ERLDTAYADSLAALPAGQARDRGVDYGKRAAARIIELREGDGRFADVPFTASPAPGVWR
                     PTPPAFQPFIDTWLARLRPLLLASPQQFRPGEPPALSSAAYAKDVQELKVMGAKTGSGR
                     SAQQTETALFFSGNLVVQVQTAVRDHAARHRLGIAETARLFAAVNASATDAVVTAWDAK
                     LHYGTWRPITAIRLADTDGNPATTADPAWEPLLLTPPHPDYIAGHTTVAAAVARAMSGV
                     LGTSHIDLHVPSEATGNTRFYGSADDLNRDVVDARVWGGVHSRTADVVGCRAGTRLAAW
                     ALEHYFQPVAKDGTQPSPPGRSAEPKCGEDTD"
     gene            4833..5297
                     /locus_tag="S1361_RS14270"
                     /old_locus_tag="S1361_14250"
     CDS             4833..5297
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009294538.1"
                     /locus_tag="S1361_RS14270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14250"
                     /product="hypothetical protein"
                     /protein_id="WP_208032226.1"
                     /transl_table=11
                     /translation="MAWEEWERAKAAAAAGQRTRMRLNQAGSSGSGPADLVVHQDDLGA
                     VGHEAFILHGELSKKADIAAAGSGSDASGSTMQAAAALKSHHLGLGSELESTVEIWTSQ
                     VKHVLQACAHISDHLDYSKKLHARDDARIAADLSGRAGPVPVSALNEYFE"
     gene            5306..6820
                     /locus_tag="S1361_RS14275"
                     /old_locus_tag="S1361_14255"
     CDS             5306..6820
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009294440.1"
                     /locus_tag="S1361_RS14275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14255"
                     /product="hypothetical protein"
                     /protein_id="WP_208032227.1"
                     /transl_table=11
                     /translation="MGDFTYSDLMSLDLTKLGTAVSDWKAMAGDLAELADDARDGLVKK
                     SEGARWKGVNADVTREFVRKTAKEFTDLQTEAESIAAVLADAHTELTTYQKQAKSLTDA
                     ARKGNPAHDPPDPALLISDGPGGTVRVVEAMCTPDGPSQRTKDYIQWYADTLTGIVQHA
                     AEVDAAAVRALRKSHGNDPHNAGHAKYTSLDEEQLPRAEELAALGRDADEKQRAELKRL
                     WESLSPEARARLWLAKKDDLMGAGVLSPTMPQVAADAGAGRHGSESPGFDEWATKRKME
                     LLTEGADWKGMTDASRNMAHYLSNSGTPMGLPVDKMMTDVPAFKTYVDDTVRLNQDAWR
                     EQALKEFRKNGGKPVAFPVEAKRDTNFYFTKELDENWFYAVGGANSNVTGVVTAVPDGH
                     GNAKIGIDYQANVWDRYNWDEGKGVTIGPLDIPDGQMAKLHRTGLAQEFDMAGSSGVRH
                     YDLGSSQPNNDPLPGPDESRDGRMDPGREQQQGRTTGRETGRTAVR"
     gene            6901..7503
                     /locus_tag="S1361_RS14280"
                     /old_locus_tag="S1361_14260"
     CDS             6901..7503
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009294450.1"
                     /locus_tag="S1361_RS14280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14260"
                     /product="hypothetical protein"
                     /protein_id="WP_243769169.1"
                     /transl_table=11
                     /translation="MAGVTTAALTVTGAVVAAGSLLGGGGDRPADRGADTRWAEGIRPE
                     WMSEHMGLDVPATARSAQAAYKVTSRFDTGLLTFTLTRSEAEAYLEKHHPTGKWLTPTA
                     AQPDTPPSDFAHFGLPEPETFKDGMRYGDVCPGTDDEPAGTPGVLTTDPYDTSDDKCTS
                     LYAHEYAPNRTRIYLRTHFEPGISPLPTPSSAPSPAR"
     gene            8161..9840
                     /locus_tag="S1361_RS14285"
                     /old_locus_tag="S1361_14265"
     CDS             8161..9840
                     /GO_function="GO:0016791 - phosphatase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1054: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: protein motif:HMM:NF018884.4"
                     /locus_tag="S1361_RS14285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14265"
                     /product="GAF domain-containing SpoIIE family protein
                     phosphatase"
                     /protein_id="WP_208032229.1"
                     /transl_table=11
                     /translation="MEDVGSVRTAVLREDEFDSGAFQASASIVQAGFYCWEIATGEVSC
                     DPLTLALHGLPENGPSDISSFLATVHESDLADVRDALGLIAESCGNYQIEYRVTSDDGR
                     LRSLEARGRVLPGADGLPARMVGVVMDTTAVHERHEAEKRRLYERATRDRWMRELTSAL
                     AAAVTVRDIMTAAQAGLRTFGADALAVIAPEGNRLTVVASCADDEQKEDSLRVLDATAR
                     ALVEESLVRRAPVLVRSADELITDHPHLAPLAQSAPQAWAAVPLTDSRGRASSCLVSFP
                     EPQEFLTEERALLVAAMGLLAQSLERAGMYESEHALATELQRGMLPRGPLTVPGVTIAA
                     RYQAATSGMWIGGDWYDAISLPDGGVALVIGDVQGHSVHAASLMGRLRTAVHAYANEGH
                     PPAAVLERTNRLLAELNTDPDSALFATCCYMALNPFDGTLRVCRAGHPAPALITPRKPP
                     RLLEVPGGLPLGIDREQRYPTTRLRIAPGSVLALTTDGLLEAVNKDIDQGTERFLRGLR
                     GAPTADLERVVDDLLDGTQKAHGLGDDVALLLARLNRPGHRS"
     gene            10001..10993
                     /locus_tag="S1361_RS14290"
                     /old_locus_tag="S1361_14270"
     CDS             10001..10993
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052: Terpene synthase/cyclase metal-binding domain
                     protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF040195.3"
                     /locus_tag="S1361_RS14290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14270"
                     /product="hypothetical protein"
                     /protein_id="WP_208032230.1"
                     /sec_met_domain="T1TS (E-value: 4.7e-64, bitscore: 216.2,
                     seeds: 237, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDNFRIPDLYIPVPAALNPELQEAAAAAEAWLDEFGLVPTEEARR
                     HVQRTRVDRLTAWLCPNAEQEALTLITQWNAWLFQLDDQFDDDPVRGYQPERWREAFGP
                     LFAVFDGTVAAGRLARSLADLWRRTTAVRSSAWQRRFIPHLLWYFDSYRADMIHREEGR
                     VPGLQQYLAHRRASFAFDAVLDLMEIGTGVDLSDQLHANPAFADMREAVIYANACINDL
                     YSLPKELAHDYAFNAVTVICHHHRCSLQEAVERVAVMQAGYVQRILDLEQVLPERLTRS
                     GLADDVDEALLCVRDFHALTAGNVAWSKETGRYAEIETEPTYLADLFIP"
     gene            11295..11984
                     /locus_tag="S1361_RS14295"
                     /old_locus_tag="S1361_14275"
     CDS             11295..11984
                     /NRPS_PKS="Domain: Abhydrolase_1 (37-145). E-value:
                     5.9e-11. Score: 34.4. Matches aSDomain:
                     nrpspksdomains_S1361_RS14295_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005318295.1"
                     /locus_tag="S1361_RS14295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14275"
                     /product="triacylglycerol lipase"
                     /protein_id="WP_243769170.1"
                     /sec_met_domain="PF00561 (E-value: 3.5e-08, bitscore: 32.2,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTLAGAAVAVAAALLAVHASLPAQASNSSTFDSTSNPVLFVHG
                     YTGDAGNWNTMAGRFGTDGWPSSYLDQWSYDWHQSNATTAQQLSAEVDRLLAATGATKV
                     DIVSHSMGGLSSRYYLKNLGGASKVDAWVSLGGPNHGTDSANSCLDTSCTEMRIGSGFL
                     AALNSGDETPGSPRYATWWSPCDTVINPDSSVSLSGAANTKTACLTHTGLLTDATVYAQ
                     TRDMING"
     aSDomain        11406..11729
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S1361_RS14295_Abhydrolase_1.1"
                     /evalue="5.90E-11"
                     /label="S1361_RS14295_Abhydrolase_1.1"
                     /locus_tag="S1361_RS14295"
                     /protein_end="145"
                     /protein_start="37"
                     /score="34.4"
                     /tool="antismash"
                     /translation="NPVLFVHGYTGDAGNWNTMAGRFGTDGWPSSYLDQWSYDWHQSNA
                     TTAQQLSAEVDRLLAATGATKVDIVSHSMGGLSSRYYLKNLGGASKVDAWVSLGGPNHG
                     TDSA"
     gene            complement(12270..14231)
                     /locus_tag="S1361_RS14300"
                     /old_locus_tag="S1361_14280"
     CDS             complement(12270..14231)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0008152 - metabolic process [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009188590.1"
                     /locus_tag="S1361_RS14300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14280"
                     /product="TIGR03960 family B12-binding radical SAM protein"
                     /protein_id="WP_208032231.1"
                     /sec_met_domain="PF04055 (E-value: 5e-16, bitscore: 58.3,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVESVFPQLEALLPHVQKPIQYVGGELNSTVKPWDECDVRWALM
                     YPDAYEVGLPNQGVMILYEVLNEQEGVLAERTYSVWPDLEALMREHGVPQFTVDSHRPV
                     KAFDVFGLSFSTELGYTNMLTALDLAGIPLESKDRTEDDPIVLAGGHAAFNPEPIADFI
                     DAAVIGDGEQAVLDMTRIIREWKAEGRPGGREEVLFRLAKTGGVYIPAFYDVEYLPDGR
                     IARVVPNKSGVPWRVSKHTVMDLDEWPYPKQPLVPLAETVHERMSVEIFRGCTRGCRFC
                     QAGMITRPVRERSITGIGEMVDKGLKATGFEEVGLLSLSSADHSEIGDIAKGLADRYED
                     DKIGLSLPSTRVDAFNIDLANELTRNGRRSGLTFAPEGGSERIRKVINKMVSEDDLIRT
                     VATAYGNGWRQVKLYFMCGLPTETDDDVLQIADMATKVIAKGREVSRSNDIRCTVSIGG
                     FVPKPHTPFQWAPQLSAEETDARLEKLRDKIRGDKKYGRSIGFRYHDGKPGIVEGLLSR
                     GDRRIGAVIRAVYDDGGRFDGWREHFSYDRWMACADKALAPYGVDVDWYTTRERTYEEV
                     LPWDHLDSGLDKDWLWEDWQDALDETEVEDCRWTPCFDCGVCPQMDTHIQIGPTGKKLL
                     PLTVKNAGPAPAASGHSH"
     gene            complement(14344..15846)
                     /locus_tag="S1361_RS14305"
                     /old_locus_tag="S1361_14285"
     CDS             complement(14344..15846)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019065561.1"
                     /locus_tag="S1361_RS14305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14285"
                     /product="CYTH and CHAD domain-containing protein"
                     /protein_id="WP_208032232.1"
                     /transl_table=11
                     /translation="MAEAKREIERKYESDDSGLPDLTGAGGVAAVLDKGLVDLDATYYD
                     TADERLTAASLTLRRRTGGADAGWHLKFPVAPGVRDEIRAPLSDTVPEDIAALVRSRVR
                     DTELIPLVRLRSSRDVRHLVDAEGTLLAEASLDTVTAERLTGKRRAAQWTEIEVELADG
                     GDPAVLDQLEKRLRKAGVRPAASPSKLARALELTAGRRRGGKTGPPPPVTAGDHVLAYL
                     RTQRDTLVELDPAVRRGLPDAVHRMRVATRRARSTLRTFGTVLDRTVTDPLGAELKWLA
                     AELGTDRDQEVLADRLKTALDALPPALVTGPVPERLTAWADARHRSAHAHLTGVLDSRR
                     YLTLLDTLDALLADPPLRKAAGRKPGKVLGKAVGKDEKKLAAVLEHALELPPGQDRDLA
                     LHEARKKAKRTRYAAEAATAALGAPARALTAGMKSLTTLLGDHQDGVMARRTLLELAAV
                     AHAAGESAFTYGVLYGREEARAAATEAELPARWRKIRSGAAG"
     gene            complement(15898..17094)
                     /gene="rodA"
                     /locus_tag="S1361_RS14310"
                     /old_locus_tag="S1361_14290"
     CDS             complement(15898..17094)
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="rodA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_020136171.1"
                     /locus_tag="S1361_RS14310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14290"
                     /product="rod shape-determining protein RodA"
                     /protein_id="WP_208032233.1"
                     /transl_table=11
                     /translation="MTGTNSFSVSGYGPARAGWTRIFARDSLARRLDWPMLFAATALSL
                     LGSLLVYSATRNRTELNQGDPYFFLVRHLMNLGIGVALMIGTVWLGHRALRNAVPILYG
                     LSVLLALVVLTPLGATINGQRNWLVIGGFSLQPAEFLKVTIILGMAMMLAARVDAGDKP
                     YPDHRTVFQSLCLAAVPILILLLMPDLGSVLAMVAIILGVLLASGASNRWVFGLLTAGV
                     IGCIAIWQLHILDEYQINRFAAFANPDLDPAGVGYNTNQARIAIGSGGLTGAGLFHGSQ
                     TTGQFVPEQQTDFVFTVAGEELGFVGAGFIVFLIGVVLWRACRIARDSTELYGTTVAAG
                     IVAWFAFQSFENIGMTLGIMPVTGLPLPFVSYGGSSMFAVWVAVGLLQSIKVQRPMSA"
     gene            complement(17091..19343)
                     /gene="mrdA"
                     /locus_tag="S1361_RS14315"
                     /old_locus_tag="S1361_14295"
     CDS             complement(17091..19343)
                     /EC_number="3.4.16.4"
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_process="GO:0009252 - peptidoglycan biosynthetic
                     process [Evidence IEA]"
                     /codon_start=1
                     /gene="mrdA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007382013.1"
                     /locus_tag="S1361_RS14315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14295"
                     /product="penicillin-binding protein 2"
                     /protein_id="WP_208032234.1"
                     /transl_table=11
                     /translation="MTNIPETGRTPRVQTRLVVIQILVLSLLGTLGGRLWYLQIREGAD
                     YQKEASGNHVQQVVDPAVRGDILDARGVPLADNETRLVVSASRTDLLKQKDDGKAVLTK
                     LAGVLGMSPKEVMQKVRLCDAKTPQPCWNGSPYQPIPITDEATARQALQIRERSEDFPG
                     ITAEPEAVRRYPGPGKSNTAQVLGYLSPVTDDEIQKAKDTDSPYLRSDMVGRSGLERTY
                     DKVLRGKAGVTRYEVDNLGRVIGKARSDAAEPGSNLVTSIDSRVQRVAEYELDKAMKAA
                     RKQFDKITGTNYKADSGAVVVMEAKTGRIVAMASAPTYDPNVWVGGISGKDYKALTGKD
                     SDYPLLNRAIQGQAAPGSTFKVVSTAAAVEAGYDFDGRYPCTSSYSVGGQVFKNFEGES
                     FGPIPLGRALEVSCDTVFYYLADREWKKDGGINPKKGQPKDYFYKAAHQFGLGSETGID
                     LPNEVTGRVPDRQWKLNYWKANKDAWCKTGKKDGSYVEKIAYENCLEGNKMREGDSINY
                     SIGQGDTLVTPIQEAVIYGAVANGGTMYQPTIGKAIISPDGRSVQEIKPKKRGKLPVSQ
                     ATLRGMNDAFAGVITRGTAAWKFGGWPQDKIPLHAKTGTAEVYGKQTTSWLATYSKDYT
                     VIMTIAQAGTGSGASGEAVRNIYSALYGVQADGSIENKKALLPEPQKGLPKVRTDGTIA
                     APKITGDPAKEAEAAQKNNPTNGDDQQPAGTTPSPTTGNRDTRRRPRRRRSRRTPS"
     misc_feature    19359..19373
                     /note="TFBS match to SypG, Regulator of biofilm formation
                     and host colonization, confidence: weak, score: 18.86"
                     /tool="antismash"
     gene            complement(19505..20182)
                     /gene="mreD"
                     /locus_tag="S1361_RS14320"
                     /old_locus_tag="S1361_14300"
     CDS             complement(19505..20182)
                     /GO_function="GO:0003674 - molecular_function [Evidence
                     IEA]"
                     /GO_process="GO:0008360 - regulation of cell shape
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="mreD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004988142.1"
                     /locus_tag="S1361_RS14320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_14300"
                     /product="rod shape-determining protein MreD"
                     /protein_id="WP_208032235.1"
                     /transl_table=11
                     /translation="MRVNRILLSTALVVVALVVQVSVLARLHLPGAVPDLLLLTVLGLA
                     MVYGHVGGALVGFGAGLLADLAPPADHAAGRYALVLCVIGYLAGLIRPENGRLKSATGP
                     MAVVVAAAIGSTLLYAGVGALVGDTAARHVGLSGLLFSAALYDLLLAPFVVPGVMWLAR
                     HSDNDPLTESGPTAKAGDISSGWLSSGTGLRIGSQRGGLGALKAKARTRSAKVGRIKGV
                     KRL"
ORIGIN
        1 tccgggagcg ggccgagcgc gccgcggccg aggggcggac ggtgagcgcg cgggacggct
       61 ggctgcgcgc cgccgggtat ttcggcaccg cgctggtggg cgtggacgcg gccgccgatc
      121 ccgggaagca gctggccgag gtgtttcccg agcaccgcgc ctgcttcgac cgcttcctcg
      181 cggcctggga cccgcccgcc gagcccgtgt ccattcctta cgaggacgca tccctgcccg
      241 ggtacctggt cggcccgccg ggcgggtccg gcccgcagtc cacgctgatc gtcaacaacg
      301 gcagtgacgg cccgatcagc gccgcctgga cgctgatcgg cgccccggcg gtggcccgcg
      361 gctaccgcgt cctgctcttc gacggcccgg gccagcagtc gatgctcttc gagcggggag
      421 tgaccttccg gcccgactgg gagaacgtga tcaccccggt cgtcgacttc ctcctggccc
      481 gccccgacgt cgccccccgg cggctcgccc tggccggcat cagccaggcc gggtactggg
      541 ttccgcgggc cctcgccttc gagcaccgga tcgccgccgc ggtcgccgac ccgggggtgg
      601 tccgggtggc ggacagctgg tggcacaacc tcggtcccga cctgcgcgcc ctgtgggagt
      661 ccggcgaccg cgccgccttc gacggcttca tcacagaggg cctgcgccag gatccggccc
      721 tggccgcgca gtggcgctgg cgggccaagc cgtacggcat cgactcgccg ttcgacctgc
      781 tgacggaggt ctcccggtac gacgtcacac ccgtcgccga ccggatcacc acccccctgc
      841 tcatcaccga cccggacggc gaacacttct ggccgggcgg ctcccgcgag ttgtacgacg
      901 ccctgcccag cccgaagcac ctggtccgct tcaccgagga ggagggcgcc catctgcact
      961 gcgaaccgat gggccgcgca ctgttcgagc agcgcgtctt cgactggctg gacgaccacc
     1021 tgcccccggc ggacggccgg acaacggggg aatgacacct caggccgccc gggccggccc
     1081 cgagcggcca ctcctgcggg cgggctacgc cgagcgggac tgcgtcgagc ggggctgcgt
     1141 cctcgggatc cttgacgtga agaacagcgc cagcacggag gcgaacgcga ggatcgcgag
     1201 cgcggcgcgc aggccggcca gccgggcgtc ggcgttcgcc ttcagcgcgg cccgggcaac
     1261 ctcctcgttc gtgcccgccg cgtcgagagc agccttgagc ccggcgtccg acaggaacgt
     1321 cacgccgctc tgaagttcga cggcggcctg gctcttgacc tcggccggga tcgccggatt
     1381 ctgctcgaca ctggtcagga aggaagacgc gagcacggcg atcaggatcg atccggccag
     1441 cgccgcgccc atcgaggagc cgaggttggt ggcggcgttc tggatgccgc cgacttccgc
     1501 actctgctcg tccggcaccg acgagacggt gacggacccg agctgggacg cgagcgcgcc
     1561 catgccgagg ccgaccagca gaagggggac ggtgacgatc tccgctccgg cgcccgcgtc
     1621 cagcgcggcc atcagggcca ccgcaccggc gagcaacgcg aggatcccga gccgcaccac
     1681 ccgcctcggt gagacgtccg ggaagaagcg tgggatcagg gtcgcggctg ccagcatggt
     1741 cagcgacagg ggcagcagcc atgcgcccgt cctgagcgcg gacaggccca gggcgaccga
     1801 cagatagagc ggtacgacga agaacacgcc catcagaacg aggtactgga agaagaacat
     1861 ggtcaggccc ccggtgagct gcttgttctg cagcagggcc gggtcgatga gcggctctct
     1921 gtgccgctgc acgagacgga cctgccagcg gaggaagagc cacaccagaa gcaggcccgc
     1981 caacatcagc cagacgacca gcgagaatcc cagccacgcg ggcgcatggg gtttcggccg
     2041 gaaccagccc cattcgtccg agcggagcac gccgtagacg aaaaggccga gccccagggc
     2101 gcacagcagc gtgccgatga gatcgaggtg cggacgtttg ccgcccacga cgtcggcaat
     2161 gcggcgggcg aacgccagaa tgccgatgac caccagtacc tcaccggcga aaacccagcg
     2221 ccaggagagg taggtcgtgg cgaaaccccc aatcagtggc ccgagtgcga tcgccacggc
     2281 acccgcggcc gcgacgagtc cgtaagcggc gggacgccgt tccgcggtga agttgccggc
     2341 cacgagcgcc acgatcgcgg gcaggatgag cgccgccccg atgccctcca ggaatgacca
     2401 gccgagcagc agcacgggca gattcggcgc aagcgccgtg gtgagggagc cgcccgcgta
     2461 aatgcagcaa ccgatcatga acgcgcgtct gcggccgatc agcgccccga ccttgccgcc
     2521 cgggatcatg aacatcgcca tcacgagcgt ataggccgtg atggcgccct ggatcccggt
     2581 caccgtcgtg cccacatcat cggccacggt tgcgatggac acgttcatca cggagctgtc
     2641 gagcgccatc aggaactgcc cggccgcgag ggtccacagg accgaacgcg cccctgccga
     2701 actgtcggca gcgcctgtcc cgggtgtcat cggccaagca tttcagccgc cgcggcgaca
     2761 gatccccgac gcgccacgga gttcagccgc ttggccgaga ccaaccagcc gaagccggcc
     2821 tggcggaagc cgccgggtcc gccgggagaa ccaggtgacg ccggcggacg gtgccgcaaa
     2881 gcaccgtccg ccgccggccc agccacatgc ccggcgcggg ccccgcgttc ctgaccgtcc
     2941 cccacactcg gcccgcggtc tcggagagca gcgctaccag acgccggtgc agcctgctgc
     3001 tggggggcat gacgcgtccc cggctggacg ccgggtccac ttcggttctg tggttcagtc
     3061 ggtgtcctcg ccgcacttcg gctcggcgga tctgcccggc ggggacggct gggtaccgtc
     3121 cttggcgacc ggctggaagt agtgctccag cgcccatgcg gccagccggg tgccggcccg
     3181 gcagccgacc acgtccgccg tgcgggagtg gacgccgccc cacacacggg cgtcgacgac
     3241 gtcccggttg aggtcgtcgg cggacccgta gaaccgcgtg ttgccggtgg cctcggaggg
     3301 gacgtggagg tcgatgtgcg aggtgccgag aacgccgctc atggcgcgtg ccacggccgc
     3361 ggcgacggtc gtgtggccgg cgatgtagtc cgggtgtggc ggagtgagga gcagcggctc
     3421 ccaggccggg tcagccgtcg tcgcgggatt gccgtcggtg tcggcgaggc ggatggcggt
     3481 gatcggccgc caggtgccgt agtggagctt ggcgtcccac gcggtgacga cggcgtcggt
     3541 cgccgacgcg ttcaccgcgg cgaacagccg ggccgtctcg gcgatgccga gccggtgccg
     3601 ggcggcatgg tcccgtacgg ctgtctggac ctgtacgacc aggttgccgc tgaagaagag
     3661 ggcggtctcg gtctgctgcg cgctcctgcc cgagccggtc ttcgcgccca tgaccttcag
     3721 ctcctggacg tccttggcgt aagcggccga ggagagggcg gggggttcgc cggggcggaa
     3781 ctgctgcggg gaagcgagca ggaggggacg gagcctggcg agccaggtgt cgatgaaggg
     3841 ctggaacgcg ggcggagtgg gccgccagac ccccggtgcg ggggaagcgg tgaaaggaac
     3901 gtccgcgaac ctgccgtccc cttcccggag ttcgatgatg cgggcggcgg cgcgctttcc
     3961 gtagtccacg ccccggtccc tggcctgacc ggccggaaga gcggcgagcg agtccgcgta
     4021 cgcggtgtcg agccgctcct tgaaggccgg gaagtaggtg agcagcacgt cgtgggccgc
     4081 agtggcggcg gccgctgcgg aggatgcctt ggccggaccg cgctcgtgcc atttgtacag
     4141 ggcgtagcgg ccttcgatcc ccaccacggc gttgtacacg gcgacggaga cgaacccctc
     4201 ccagatcgct gcctgcccgg aggggcgtgg gccgaggctg gtcgtgatcg tgtcggtggc
     4261 gatggcgttc cactcgcgga ccacggctgc cgggtccgcc gccgtccggg tgtccgtgtc
     4321 ggggggactt gtcgcagcgg tgagcgtcac cagggcgatg gccgcgacgg cgcagaggaa
     4381 tgcccggaca cgtgaacgcg gaggaacggg aagagggggc ttttgatgca cagcgtgctc
     4441 cctagcgtcg agtgcccaag gcttagcaac ggccccctgc gtgagcaaga caactcgccg
     4501 cagaacggac aggcccagcg cgccctcgaa cacctcaccg cccgtacgag aagatcatcg
     4561 gcaccggacg gaccctgcac ccaccccaga ccccggagaa ccgcgctgca actgggcccg
     4621 agccgcaaac ctgcccgtga acggccctgc ccatcacgag ctgtggtggc ctgcctgtgg
     4681 caggccactt gcacgtaccc gtccctgccg gcctgcgcgg tgctgagtcg gcaggcaacg
     4741 cgaacaaact gaagcgcctt cggcagagtt ggtaccttcg gtggtgcgct ggccaagtgt
     4801 cagtgtctgg tcgaccagag gacgggggtc ccatggcgtg ggaagagtgg gagagggcca
     4861 aggcagcagc ggcagccggc caacgaacgc ggatgcggct gaaccaggcc ggatccagtg
     4921 ggtccggccc cgccgatctc gtcgtgcacc aggacgacct gggggccgtc ggccatgagg
     4981 cgttcatcct ccacggcgaa ctgagcaaga aggcagacat cgcggctgcg ggctccggaa
     5041 gcgatgcttc gggatccacc atgcaggccg ccgccgcgct caagagccac cacctcgggc
     5101 tcggttcgga actcgaatcg accgttgaga tctggacctc acaggtcaag cacgttctcc
     5161 aggcgtgtgc ccacatctcc gatcacctcg actacagcaa gaagctgcac gcacgcgatg
     5221 acgcacgcat cgccgcggac ctcagtggcc gtgccggacc ggtacccgtc tcggcactga
     5281 acgagtactt cgagtaaggg aagtaatggg agacttcacc tactccgacc tcatgtctct
     5341 ggacctcacc aagctgggca cggcggtgtc cgactggaag gcgatggccg gtgacctggc
     5401 cgaactggcc gacgatgcgc gggacggcct ggtcaagaaa tccgaaggcg cccgctggaa
     5461 gggcgtcaac gcggacgtca cacgtgagtt cgtacgcaag acggccaagg aattcactga
     5521 cctccagacc gaggcggaga gcatcgccgc cgtgctcgcc gacgcacata cggagttgac
     5581 gacctaccag aagcaggcca agagcctcac cgacgcggca cgcaagggca atcccgccca
     5641 tgatcctccg gatcccgctc tcctcatatc ggacgggccg ggcggcacag tccgggtggt
     5701 ggaagcgatg tgcactccgg acggcccgag ccagcggacc aaggactaca tccagtggta
     5761 cgccgacaca ctcaccggaa tcgtccagca cgctgccgag gtcgacgctg cggcggtacg
     5821 tgcactgcgc aagagccacg gcaacgatcc gcacaacgcc gggcacgcca agtacacctc
     5881 cctcgacgag gaacaactac cccgggcgga ggagctggcc gcgctgggcc gcgacgccga
     5941 cgaaaagcag cgggcagagc tgaagcgcct gtgggaatcg ctgagccccg aggcgcgggc
     6001 tcgcctctgg ctcgcgaaga aggacgacct gatgggggcc ggcgtactga gccccaccat
     6061 gccacaggtc gcggccgacg ccggggcagg gcggcacgga tcggagtcac ccggattcga
     6121 cgagtgggcc accaagcgca agatggagtt gctcacagag ggcgccgact ggaaaggcat
     6181 gacggacgca tcccggaaca tggcgcacta tctgagtaac agcggcaccc ccatgggcct
     6241 gcccgtggac aagatgatga cggatgtccc cgcgttcaag acgtacgtcg acgacacggt
     6301 gcggctcaac caggacgcct ggcgcgagca ggctctcaaa gagtttcgaa agaacggcgg
     6361 caagccggtg gccttcccgg tggaggcgaa gcgcgacacg aacttctact tcaccaagga
     6421 actcgacgag aactggttct acgcagtggg tggcgccaac agcaacgtga ccggtgtggt
     6481 cacggcggtt cccgacggcc acggcaacgc gaagatcggc atcgactacc aggcgaacgt
     6541 ctgggaccgg tacaactggg acgaaggcaa gggggtcacc atcggcccac tggacatccc
     6601 ggacggacag atggcgaagc tgcaccggac cgggctcgcc caggagttcg acatggcggg
     6661 cagcagcggt gtccggcact acgatctcgg ctcttcacag cccaacaacg acccactacc
     6721 gggtcccgac gaaagcaggg acggacgcat ggaccccggc cgggagcagc agcagggccg
     6781 cacaaccggc agggagacgg gcaggacggc ggtccggtga acgacttctc cccctgcagg
     6841 actcccgagg gccccgtcgg ggacggcggc agcagccgtg gtcgccaacg aaagtggctc
     6901 gtggcaggcg tgaccaccgc cgcgctgacc gtgaccggcg ccgtggtcgc cgcgggatcg
     6961 ctcctaggcg gcggcggtga ccggccggcc gacagggggg cggacacgcg gtgggccgag
     7021 gggatcaggc ccgagtggat gagcgagcac atgggtctcg acgtcccggc cacagcccgg
     7081 tccgctcagg ccgcctacaa ggtcacgtcc cgcttcgaca ccggcctcct caccttcacc
     7141 ctgacgaggt ccgaggccga ggcctatctg gagaaacacc atccgaccgg caagtggctg
     7201 acgccgacgg cggcccagcc cgacacacct ccgtcggatt tcgcccactt cgggctgccg
     7261 gaacctgaga ccttcaagga cggcatgcgg tacggcgacg tctgccccgg caccgacgac
     7321 gagcccgccg gcactccggg cgtcctcacc accgatccgt acgacacctc agacgacaag
     7381 tgcaccagct tgtacgcaca cgagtacgcc ccgaaccgca cccgcatcta tctccgcacg
     7441 cacttcgaac caggtatcag ccccctcccg acgccctctt ccgcaccgtc accggcacgc
     7501 tgagcgcgca cgccggtcct gggccggtag cgagttcccg gacaggcctt ccaccccgtc
     7561 gggcggatgg cgggcgcggt accggttggt cacacgccgg cgagccctct tcctgcaagg
     7621 gaaaaggggg ggctcaatgg cgatgctggt catgcacaag ccggaggcaa agacccactc
     7681 cgcttcgcag acgagcgctg agcacttccg gggcccggca cgagacgcca gcggtgccga
     7741 cacacgaggc cggcacagcc accgcctcgt cccggcccac ctccgccaac ggctgtccgt
     7801 tcagccgttg agcgtgcttg acggccggtg gtgggcgcgc ggttgtggtg aaactcttcg
     7861 cgtggctggc agacgtagtc tgccgagtgg ggcatctggc gcaagatccg gaaagtcact
     7921 accatgcgca cgatccggcc acagtcgggt cgttcaggcg atcttccctg gaagagcggg
     7981 agcgcattca gctgcgaaac ccccgtcacc tattggaggg gttggtgtcc cagtcccgta
     8041 ggtctcaagt cgccatactg gctggtttcc gtcggccgct caccacagtt cgtggccgat
     8101 tcggttgagc accgttgacc cctcagaggg aagtagttca cgccgcggca gggagatcta
     8161 gtggaagacg tcggatcggt gcgcactgcc gtgctccggg aagatgagtt cgattccggc
     8221 gcattccagg ccagcgcgag catcgtgcag gcgggcttct actgctggga gatcgccacg
     8281 ggcgaggtga gctgcgatcc cctcaccctc gcgctgcacg gcctgcccga gaacggcccg
     8341 tcggacatct cgagcttcct ggccaccgtg cacgagtccg atctggccga tgtgcgcgat
     8401 gccttgggtc tgatagcgga gtcctgcggc aactaccaga tcgagtaccg cgtcacctcc
     8461 gacgacggcc ggctcaggtc cctggaagcc cggggccgcg tcctgcccgg cgctgacggg
     8521 ctgccggccc gcatggtcgg agtggtcatg gacaccacgg ccgtccatga acgccacgag
     8581 gcggagaagc gtcggctgta cgagcgcgcc acccgtgacc gctggatgcg ggagctgacc
     8641 tcggctctgg ccgccgcggt gacggtcagg gacatcatga ccgccgcaca agcaggattg
     8701 cgtaccttcg gagcggacgc actggcggtg atcgccccgg aagggaaccg gttgaccgtc
     8761 gtcgcctcgt gcgccgacga cgagcagaag gaggactctc ttcgagtcct cgacgccacg
     8821 gcccgcgccc tcgtggagga gtcactcgtc cggagagcgc ccgttctcgt ccgctccgcg
     8881 gacgaactga tcaccgatca tccgcacctg gcaccgctcg cgcagtcggc cccacaggcg
     8941 tgggcggcgg tgccgctcac ggactcgcgc ggccgcgcca gttcctgcct cgtcagtttc
     9001 cccgagccgc aggagttcct gaccgaggag cgggccctcc tggtcgccgc catgggactg
     9061 ctcgcccagt cactggagcg agccggcatg tacgagtcgg aacacgcact cgccaccgag
     9121 ctccagcgtg gcatgctgcc gcgcgggccg ctcaccgtgc cgggtgtgac catcgccgcc
     9181 cgctaccagg ctgccacctc cggcatgtgg atcggtggcg actggtacga cgccatcagc
     9241 ctgcccgacg gtggcgtggc tctggtcata ggagacgtgc agggacacag cgttcacgcc
     9301 gcgtctctca tggggcggct gcgtaccgcc gtgcacgcct acgcgaacga aggacacccg
     9361 cccgcggccg tcctggaacg caccaaccgc ctgctggccg agctgaacac cgacccggac
     9421 tcggccctgt tcgccacatg ctgctacatg gcgctcaacc ccttcgacgg aacgctccgg
     9481 gtgtgccggg ccggtcatcc ggccccagcg ctgatcacgc cccgcaaacc gccgcgactc
     9541 ctggaggtcc ccggcggcct ccctctggga atcgaccggg agcagcggta ccccaccacc
     9601 cgccttcgca tcgctccggg cagcgtgctc gcgctgacca ccgacggcct gctcgaagcc
     9661 gtgaacaagg acatcgacca gggcaccgag aggtttctcc gaggtctgcg aggcgctccc
     9721 actgcggacc tggagagggt tgtcgacgac ctcctcgacg gtacgcagaa ggctcacggc
     9781 ctgggcgacg acgtcgctct gctcctggct cgtctgaacc ggcccggcca ccgcagctga
     9841 ccctgccctg accccgcctg ttcccaacag gccgctgtcg ccgggacctc gtatgagcgg
     9901 accaccgaat tgcccggccg ttgtgcttct ccgcagggta atttacgccg gtgtcactgg
     9961 atgtcgcgag gcagaggatt accgagaagc gagctgacga atggacaatt tccggattcc
    10021 ggacctctac atacccgtac cggcagcgct caatccggaa ctccaggagg ctgctgcggc
    10081 ggctgaggca tggctggacg agttcggcct ggtgcccacc gaggaggcgc gtcggcatgt
    10141 gcagcgcact cgtgtggacc ggcttaccgc atggctgtgc ccgaacgctg agcaggaggc
    10201 gctgacgctg atcacccagt ggaacgcgtg gctcttccag ttggacgacc agttcgacga
    10261 cgacccggtg cgcggttacc agcccgagcg gtggcgggag gcgttcgggc cactgttcgc
    10321 cgtcttcgac ggaaccgttg cggccgggcg actggcgcgc tccctggccg atctgtggcg
    10381 ccgcacgacg gctgtccgtt cctccgcatg gcagcgacga ttcatcccgc acctgctgtg
    10441 gtatttcgac agctaccggg ccgacatgat tcatcgtgag gaagggcgcg tacccggcct
    10501 gcagcaatat ctcgcccacc gccgcgcctc gttcgcgttc gacgccgttc tggacctgat
    10561 ggaaatcggt accggtgtcg acctgtccga ccaactgcat gcgaacccgg cctttgcgga
    10621 catgcgagag gcggtgatct acgcgaacgc ctgcatcaac gacctctact cgctacccaa
    10681 agaactcgcg catgactatg cgttcaacgc cgtcacggtg atctgccatc atcaccggtg
    10741 cagcctccag gaggcggtgg agcgagtggc cgtgatgcag gccggatacg tccagcgcat
    10801 cctcgatctc gaacaggtcc tgcccgaacg gctgacgcgt tccggcctcg ccgacgacgt
    10861 cgacgaggca ctgctctgcg tcagggactt ccacgcgctc accgccggga acgtcgcctg
    10921 gtcgaaggag acggggcggt acgccgagat agagaccgaa ccgacctacc tggccgactt
    10981 gttcattccg taggacccga cggccgccct gtggccgctc cacagggcgc gcaggacgcg
    11041 ccgcgccgag gaccggccgg gtggaaacat ttccgcgcac gcctcttgac cactgatacc
    11101 taccggtcag tacgctcacg ccaccctcga tgacaccggt gtcctctccc ccgtgcggcc
    11161 acggcgaacg gccccccggc atgccgccgc acgcccctag gcaggagctc ccgcgacccg
    11221 ggaaacgccc cagcgctgtc cttcgccaga acgcgccgtc gagcgctgtc ccgaacccca
    11281 cccgggagtc cgtcgtgaac aaaacccttg ccggcgcagc cgtcgccgtg gccgccgccc
    11341 ttctcgccgt acacgcctcc ctccccgccc aggcgtcgaa cagctcgacc ttcgactcga
    11401 ccagcaatcc cgtcctcttt gtgcacggtt acaccggtga cgccggcaac tggaacacca
    11461 tggcgggccg tttcggaacc gacggctggc cgtcctcgta cctcgaccag tggtcctacg
    11521 actggcatca gtccaatgcc acgaccgccc agcagctgtc cgccgaagtc gaccgtctcc
    11581 tcgccgccac cggcgccacc aaggtcgaca tcgtcagcca ctccatggga gggctctcct
    11641 cgcgctacta cctcaagaac ctcggcggag cctccaaggt cgacgcctgg gtgtcactgg
    11701 gaggaccgaa ccacggcacc gacagcgcca acagctgcct cgacacctcc tgcaccgaga
    11761 tgcgcatcgg ctccggcttc ctcgccgccc tcaactccgg cgacgagaca ccgggctcac
    11821 cccgttacgc cacctggtgg tcgccctgcg acacggtgat caaccccgac agctccgttt
    11881 ccctgtccgg cgccgccaac accaagaccg cctgcctcac ccacaccggc ctgctcaccg
    11941 acgcgacggt ctacgcccag accagagaca tgatcaacgg ctgaccgctc cccaccagcc
    12001 ggcaggggcc gctcaccgcg gcccctgcca ccgcctccag cccggcgcct ggttgaccac
    12061 cgcgaagatc gtggcgccgt ccgcatcgtc ctcacgggac attgccggcc gagtgctcgc
    12121 acgagcgccg cgctactcga ccgacggccg caggcgctgc tctccgggag cacgccgccg
    12181 acaccataga gcgaggacga ggcacgagcg aactcagaca gcgccgcagc cgcctcgccc
    12241 tcgatcaccc gatcgagcgc tcgcccacct cagtgcgagt gcccactcgc agccggcgcc
    12301 ggacccgcgt tcttgactgt cagcggcagg agcttcttcc cggtcgggcc gatctggatg
    12361 tgggtgtcca tctgcgggca tacgccgcag tcgaagcacg gggtccagcg gcagtcctcg
    12421 acctccgtct cgtcgagggc gtcctgccag tcctcccaga gccagtcctt gtccaggccg
    12481 gagtcgaggt ggtcccaggg gaggacctcc tcgtaggtgc gctcgcgggt ggtgtaccag
    12541 tcgacgtcca cgccgtaggg ggccagcgcc ttgtccgcgc aggccatcca gcggtcgtag
    12601 gagaagtgct cgcgccagcc gtcgaagcgg ccgccgtcgt cgtagaccgc gcggatgacg
    12661 gcgccgatgc ggcggtcgcc ccgcgacagg aggccttcca cgattcccgg cttgccgtcg
    12721 tggtagcgga agccgatgga gcggccgtac ttcttgtcgc cgcggatctt gtcgcgcagc
    12781 ttctccaggc gggcgtccgt ctcctccgcg gagagctgcg gggcccactg gaagggggta
    12841 tggggcttgg ggacgaagcc gccgatcgag accgtgcagc ggatgtcgtt cgagcgggag
    12901 acctcgcggc ccttggcgat gaccttcgtc gccatgtcgg cgatctggag gacgtcgtcg
    12961 tcggtctccg tgggcaggcc gcacatgaag tacagcttca cctggcgcca gccgttgccg
    13021 tacgccgtgg cgaccgtgcg gatcaggtcg tcctccgaga ccatcttgtt gatgaccttg
    13081 cggatgcgct cggagccgcc ctcgggggcg aaggtcagac cggagcggcg gccgttgcgg
    13141 gtcagctcgt tcgccaggtc gatgttgaag gcgtcgacac gggtggacgg gagggagagg
    13201 ccgatcttgt cgtcctcgta gcggtccgcc aggcccttgg cgatgtcgcc gatctccgag
    13261 tggtccgccg aggagaggga cagcaggcct acctcctcga agcccgtcgc cttcaggccc
    13321 ttgtcgacca tctcgccgat gcccgtgatg gagcgctcgc ggaccgggcg ggtgatcatg
    13381 ccggcctggc agaagcggca gccgcgggtg cagccgcgga agatctccac ggacatgcgc
    13441 tcgtggaccg tctcggcgag cggcacgagg ggctgcttgg ggtacggcca ctcgtccagg
    13501 tccatgaccg tgtgcttgga cacgcgccac gggacgccgg acttgttggg gaccacgcgg
    13561 gcgatgcggc cgtcggggag gtactcgacg tcgtagaacg ccgggatgta gaccccgccg
    13621 gtcttcgcga ggcggaagag gacctcctcg cggcctcccg ggcggccctc cgccttccac
    13681 tcgcggatga tccgggtcat gtcgaggacg gcctgctcgc cgtcgccgat cacggccgcg
    13741 tcgatgaagt cggcgatcgg ctccgggttg aaggccgcgt ggccgccggc caggacgatc
    13801 gggtcgtcct cggtgcggtc cttggactcc agcgggatac cggccaggtc cagggcggtg
    13861 agcatgttcg tgtagcccag ctccgtggag aagctgaggc cgaacacgtc gaacgccttc
    13921 accgggcggt ggctgtccac cgtgaactgg gggacgccgt gctcgcgcat cagcgcctcc
    13981 aggtccggcc acacgctgta ggtgcgctcg gcgaggacgc cctcctgctc gttgaggacc
    14041 tcgtagagga tcatcacgcc ctggttgggc aggccgacct cgtacgcgtc cgggtacatg
    14101 agcgcccagc ggacgtcgca ctcgtcccac ggcttgaccg tggagttgag ctcgccgccg
    14161 acgtactgga tcggcttctg cacgtgcggg agcagagctt cgagctgcgg gaaaaccgac
    14221 tcgacaggca tctcgcgaac cttcatgagc tgactggggg gtacccccgg ccggaggctg
    14281 ggggcggggt gaccatcaag cgtaacccgc ccggcggcct gtcccgaacg cccagccgga
    14341 tgctcagccg gccgccccgg acctgatctt cctccaccgt gcgggcagct ccgcctccgt
    14401 ggccgccgct cgcgcctcct ccctgccgta cagcacgccg taggtgaacg cgctctcacc
    14461 tgccgcgtga gccaccgcag cgagctccag gagggtgcgg cgggccatga cgccgtcctg
    14521 gtggtcgccg aggagggtgg tgagggactt catgcccgcg gtgagggcgc gggcgggggc
    14581 gcccagggcc gcggtggcgg cctcggcggc gtagcgggtg cgcttggcct tcttgcgggc
    14641 ctcgtgcagg gcgagatcgc ggtcctggcc cggtggcagc tccagcgcgt gttccaggac
    14701 ggccgcgagc ttcttctcgt ccttgcccac ggccttgccg agcaccttcc ccggtttcct
    14761 cccggccgcc ttgcgcagtg gcgggtccgc gaggagggcg tccagggtgt ccagcagggt
    14821 caggtagcgg cgggagtcca ggacaccggt caggtgggcg tgggcgctgc ggtgccgggc
    14881 gtcggcccag gcggtgagcc gctcggggac ggggccggtg accagggcgg gcgggagtgc
    14941 gtcgagggcg gttttcaggc ggtcggccag cacctcctgg tcgcggtcgg tgcccagctc
    15001 ggccgcgagc cacttcagct cggcgccgag ggggtcggtg acggtgcggt ccaggacggt
    15061 gccgaaggtg cgcagggtgc tgcgggcgcg gcgggtggcg acccgcatgc ggtgtacggc
    15121 gtcggggagt ccgcggcgga cggcggggtc cagctcgacc agggtgtccc gctgggtgcg
    15181 gagataggcg aggacgtggt cgccggcggt caccggcggc ggggggccgg tcttgccgcc
    15241 gcggcggcgg ccggccgtca gttccagggc gcgggccagt ttcgacggcg aggcggcggg
    15301 gcgtacgccc gccttgcgca gccgcttctc cagctggtcg aggacggccg ggtcgccgcc
    15361 gtcggccagt tccacctcga tctcggtcca ctgggcggcc cgcctcttgc cggtgagccg
    15421 ctcggcggtc acggtgtcga ggctcgcctc ggccagcagg gtgccctcgg cgtcgaccag
    15481 gtgccgcacg tcgcgggagg agcgcagccg gaccaggggg atcagctcgg tgtcccggac
    15541 gcgggagcgg acgagggcgg cgatgtcctc ggggacggtg tcggacagcg gggccctgat
    15601 ctcgtcgcgg actccggggg cgaccgggaa cttcagatgc cagcctgcgt ccgcgccgcc
    15661 ggtgcggcgg cgcagcgtga gcgaggcggc ggtcaggcgt tcgtcggcgg tgtcgtagta
    15721 ggtggcgtcc aggtcgacca ggcccttgtc gaggacggcg gccacgccgc cggcgccggt
    15781 caggtcgggc agcccgctgt cgtcggattc gtacttgcgc tcgatctcgc gtttcgcctc
    15841 cgccatgccc cgaatctagt gtccggggcg gcgatatggc agagggcgtc cgctgtccta
    15901 ggccgacatc gggcgctgca ccttgatcga ctggagcagg cccaccgcga cccataccgc
    15961 gaacatcgac gagccgccgt acgacacgaa cggcaggggc aggccggtga ccggcatgat
    16021 gccgagggtc atgccgatgt tctcgaagga ctggaaggcg aaccaggcga cgatcccggc
    16081 ggcgacggtc gtcccgtaca gctcggtgga gtcacgtgct atccggcagg cgcgccacag
    16141 gacgacgccg atcaggaaga cgatgaagcc ggcgccgacg aagcccagct cctcccccgc
    16201 gaccgtgaag acgaagtcgg tctgctgctc gggtacgaac tgaccggtgg tctgcgagcc
    16261 gtggaagagg ccggctccgg tgagtccgcc ggagccgatg gcgatgcgag cctggttggt
    16321 gttgtagccc acgccggccg ggtccaggtc cgggttggcg aaggcggcga accggttgat
    16381 ctggtactcg tccaggatgt gcagctgcca gatcgcgatg cagccgatca cgccggccgt
    16441 gagcaggccg aagacccagc ggttggaggc gccggaggcg agcaggacgc ccaggatgat
    16501 cgccaccatg gccagcaccg agccgaggtc gggcatgagc agcaggatga ggatcggtac
    16561 ggcggccagg cacagggact ggaacaccgt gcggtggtcg gggtacggct tgtcgcccgc
    16621 gtccacccgg gcggccagca tcatggccat gcccaggatg atcgtgacct tgaggaactc
    16681 ggcgggctgg agcgagaagc cgccgatgac cagccagttg cgctggccgt tgatcgtcgc
    16741 gccgagcggg gtgaggacca ccagggcgag gagcaccgac aggccgtaga ggatcggcac
    16801 ggcgttgcgc agggcgcggt ggccgagcca gaccgtgccg atcatcaggg cgaccccgat
    16861 gccgaggttc atcaggtgcc ggaccaggaa gaagtacggg tcgccctggt tcagctcggt
    16921 gcggttgcgg gtcgccgagt acaccagcag ggagcccagc agggacaggg cggtggccgc
    16981 gaacagcatc ggccagtcca gccggcgggc gagcgagtcg cgggcgaaga tcctggtcca
    17041 gccggcccgc gcggggccgt aaccggagac ggagaagctg ttcgtgccgg tcatgaaggc
    17101 gtcctccggc tcctccgcct gcgcggccgt ctgcgggtgt cgcggttgcc cgtggtgggc
    17161 gagggcgtgg tccccgcggg ctgctggtcg tcgccgttgg tggggttgtt cttctgggcg
    17221 gcctcggctt ccttggccgg gtcgccggtg atcttggggg cggcgatggt gccgtccgtg
    17281 cggaccttgg gcaggccctt ctgcggctcg ggcagcagcg ccttcttgtt ctcgatggag
    17341 ccgtcggcct ggacgccgta gagcgcgctg tagatgttgc gcacggcctc gccggaggct
    17401 ccggaacccg taccggcctg ggcgatcgtc atgatcaccg tgtagtcctt ggagtaggtg
    17461 gccagccagg acgtggtctg cttgccgtag acctcggcgg taccggtctt ggcgtgcagc
    17521 gggatcttgt cctggggcca gccgccgaac ttccaggccg ccgtaccgcg ggtgatgacg
    17581 ccggcgaagg cgtcattcat gcctctgagg gtggcctggc tgaccgggag ctttccgcgc
    17641 ttcttcggct tgatctcctg cacgctcctg ccgtcggggc tgatgatcgc cttgccgatg
    17701 gtcggctggt acatcgtgcc gccgttggcg acggcgccgt agatcacggc ctcctggatc
    17761 ggcgtgacga gcgtgtcgcc ctggccgatg gagtagttga tcgagtcacc ttcgcgcatc
    17821 ttgttgcctt cgaggcagtt ctcgtaggcg atcttctcga cgtaggagcc gtccttcttg
    17881 ccggtcttgc accaggcgtc cttgttggcc ttccagtagt tcagcttcca ctggcggtcg
    17941 ggcacacggc cggtgacctc gttgggcagg tcgatgccgg tctcgctgcc gaggccgaac
    18001 tggtgggcgg ccttgtagaa gtagtccttc ggctggccct tcttggggtt gatgccgccg
    18061 tccttcttcc actccctgtc ggccaggtag tagaagacgg tgtcgcagga gacctccagc
    18121 gcccggccca gcgggatggg gccgaagctc tcgccctcga agttcttgaa gacctggccg
    18181 ccgaccgagt aggagctggt gcaggggtag cggccgtcga agtcgtagcc ggcctcgacc
    18241 gcggcggccg tggagaccac cttgaacgtc gagccgggtg cggcctggcc ctgtatggcc
    18301 cggttgagca gggggtagtc cgagtccttg ccggtgaggg ccttgtagtc cttgccggag
    18361 atgccgccga cccagacgtt cgggtcgtac gtcggcgcgg aggccatggc gacgatccgg
    18421 ccggtcttgg cctccatcac cacgacggcg cccgagtcgg ccttgtagtt ggtgccggtg
    18481 atcttgtcga actgcttgcg ggcggccttc atggccttgt ccagttcgta ctcggcgacc
    18541 cgctggacgc gggagtcgat gctggtgacc aggttggaac cgggctcggc cgcgtccgac
    18601 ctggccttgc cgatgacccg gccgaggttg tccacctcgt agcgggtgac gccggccttg
    18661 ccgcgcagca ccttgtcgta ggtccgctcc aggccggagc ggccgaccat gtcggagcgc
    18721 aggtagggcg agtcggtgtc cttggccttc tggatctcgt cgtcggtgac gggcgagaga
    18781 tagccgagca cctgcgcggt gttggacttg ccggggcccg ggtagcggcg gacggcctcg
    18841 ggctcggcgg tgatgccggg gaagtcctcg gagcgctcgc ggatctgcag ggcctgcctg
    18901 gccgtggcct cgtcggtgat ggggatcggc tggtacggcg agccgttcca gcagggctgg
    18961 ggggtcttgg cgtcgcacag ccggaccttc tgcatgacct ccttggggct catgccgagg
    19021 acgccggcca gcttggtgag gactgccttg ccgtcgtcct tctgcttcag caggtcggtg
    19081 cgggaggcgg agacgaccag gcgggtctcg ttgtccgcga ggggcacacc gcgggcgtcc
    19141 aggatgtcgc cgcgcacggc ggggtcgacg acctgctgga cgtggttgcc ggaggcctcc
    19201 ttctggtaat cggcgccctc gcggatctgc aggtaccaca accggccgcc gagcgtgccg
    19261 aggagggaga ggacgaggat ctggatcacg acgagccggg tctggacgcg tggggtccga
    19321 ccggtctcgg ggatgttggt cactgcggct gtctccccct ctcagtgtgc gaacgtccgg
    19381 gcgcggcggg cgtgtgtgcg aaccgcccgt gcgcgtacga atgatgaacg accagcctgt
    19441 gcacccgcgt tccggggacg ctgacccgtt cgggtgaact cgccggggtg gaactcgccg
    19501 ccgctcacag ccgcttgacc cccttgatgc ggccgacctt ggcggagcgg gtacgcgcct
    19561 tggccttcag cgccccgagt ccgccgcgct ggctgccgat gcgcaggccg gtgccggagg
    19621 agagccagcc ggaggagatg tccccggcct tggcggtggg cccgctctcg gtgagcgggt
    19681 cgttgtcgga gtggcgggcc agccacatca cgccgggtac cacgaacggg gcgagcagca
    19741 ggtcgtacag ggcggccgag aacagcagcc cggacaggcc gacatggcgg gcggcggtgt
    19801 cgccgaccag ggcgcccacc ccggcgtaga gcagggtgga gccgatggcg gcggcgacca
    19861 cgacggccat cgggccggtc gcggacttca gtctgccgtt ctccggccgg atgagcccgg
    19921 cgaggtagcc gatgacgcac agcacgagcg cgtaccggcc ggccgcgtgg tcggcgggcg
    19981 gggccaggtc ggcgagcagg ccggcgccga agccgacgag ggcgccgccg acatggccgt
    20041 acaccatcgc caggccgaga acggtgagca gcagcaggtc ggggacggca ccgggcaggt
    20101 gcagccgggc gaggacgctc acctggacga ccagggccac gacgaccagc gcggtggaga
    20161 gcaggatccg gttgacacgc atgggattcg gctcctactg ctgttcgtcg gtggcggggg
    20221 cgtcggccga cggggtgacg gtgacggtca ccgtcggtgt cgggaccggt ttcggctggg
    20281 ccgggagcac ggtgtcccgc gggtccttct tcggcgcctg tacgaccacg ccgacgatgt
    20341 cgagcttggt gaagctgacg tacggggtga cgtagagggt gcgggtcagg ccgccgccgg
    20401 aggggtccac gcgggagacc acgccgaccg ggacgccggg cacgaacggc ttgtcggcct
    20461 gcgatccgaa cgtgacgagc cggtcgccct tcttcacctc cgccttgccg ttgagcagtt
    20521 ccacgcgcag cgggcggtcg ccctgtccgg aggcgaagcc cagttcgtcg cccgcctcca
    20581 tgcgggtgcc gacggtgaag tcggggtcgt tggccagcag cacggtggag gtgctgggac
    20641 cgacggtggt gacccggccg accaggccgt cgccgttcag gacggtcatg tcccgctgga
    20701 tgccgtcgtt ggcgccggcg tcgatggtga tggtccagga gaagccctgg gccgagccta
    20761 tggcgatgac ctgggcgccc ttgatgccgt actgcccctc gccggcgatc ttcagcagtc
    20821 tgtccagctg cttgaggcgg ctgcggttgc ggtcgtcgct gccgagcttg gccttgaggg
    20881 ccgcgttctc cttctccagc gtggcgagcc ggtcgtgccg gctgccggag tcacggaccg
    20941 cggagacggc gttgccgacc gggtcgaccg cggaggacaa cccgttctcg acc
//
