LOCUS       NZ_CP071839            21200 bp    DNA     linear   CON 20-APR-2024
DEFINITION  Streptomyces cyanogenus strain S136 chromosome, complete genome.
ACCESSION   NZ_CP071839
VERSION     NZ_CP071839.1
KEYWORDS    RefSeq.
SOURCE      Streptomyces cyanogenus
  ORGANISM  Streptomyces cyanogenus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Kalinowski,J.,
            Fedorenko,V., Yushchuk,O. and Ostash,B.
  TITLE     Complete genome sequence of Streptomyces cyanogenus S136, producer
            of anticancer angucycline landomycin A
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 8773899)
  AUTHORS   Hrab,P., Ruckert,C., Busche,T., Ostash,I., Yushchuk,O.,
            Kalinowski,J. and Ostash,B.
  TITLE     Direct Submission
  JOURNAL   Submitted (16-MAR-2021) Genetics and Biotechnology, Ivan Franko
            National University of Lviv, 4 Hrushevskoho St, Lviv, Lviv region
            79005, Ukraine
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 2020
            Assembly Method :: Newbler v. 2.8; Canu v. 1.8; Unicycler v. 0.14
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 974878.0x
            Sequencing Technology :: Illumina HiSeq; Oxford Nanopore GridION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017526105.1-RS_2024_04_19
            Annotation Date                   :: 04/19/2024 09:57:52
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 7,747
            CDSs (total)                      :: 7,656
            Genes (coding)                    :: 7,375
            CDSs (with protein)               :: 7,375
            Genes (RNA)                       :: 91
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 70
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 281
            CDSs (without protein)            :: 281
            Pseudo Genes (ambiguous residues) :: 0 of 281
            Pseudo Genes (frameshifted)       :: 129 of 281
            Pseudo Genes (incomplete)         :: 239 of 281
            Pseudo Genes (internal stop)      :: 25 of 281
            Pseudo Genes (multiple problems)  :: 104 of 281
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 06:56:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 325165
            Orig. end                         :: 346365
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP071839.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            Bacteria and source DNA available from Bohdan Ostash, 4
            Hrushevskoho St., Lviv, 79005, Ukraine.
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21200
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="amglyccycl"
                     /region_number="2"
                     /rules="(DOIS or ValA or salQ or strH or strK1 or strK2 or
                     NeoL or SpcFG or SpcDK_glyc)"
                     /tool="antismash"
     cand_cluster    1..21200
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /kind="single"
                     /product="amglyccycl"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21200
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="False"
                     /core_location="[10000:11200](+)"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11200
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(DOIS or ValA or salQ or strH or strK1 or
                     strK2 or NeoL or SpcFG or SpcDK_glyc)"
                     /neighbourhood="10000"
                     /product="amglyccycl"
                     /protocluster_number="1"
     misc_feature    complement(465..480)
                     /note="TFBS match to CopR, Copper-responsive regulator,
                     confidence: weak, score: 17.24"
                     /tool="antismash"
     misc_feature    complement(593..608)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 19.51"
                     /tool="antismash"
     gene            623..1504
                     /locus_tag="S1361_RS01380"
                     /old_locus_tag="S1361_01365"
     CDS             623..1504
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Abhydrolase_1 (24-262). E-value:
                     2.2e-34. Score: 111.1. Matches aSDomain:
                     nrpspksdomains_S1361_RS01380_Abhydrolase_1.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1036: alpha/beta hydrolase fold protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994672.1"
                     /locus_tag="S1361_RS01380"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01365"
                     /product="alpha/beta hydrolase"
                     /protein_id="WP_208030016.1"
                     /sec_met_domain="PF00561 (E-value: 4e-26, bitscore: 91.0,
                     seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.3e-20, bitscore:
                     73.8, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTELSISTAAGVFDAIVAGPPEGRPVLLLHGFPQTGLVWRRQIAA
                     LAKHGYRVVAPDQRGYSPRARPERPEAYRIGLLVEDVVAITEELGWAAFDLVGHDWGGA
                     VAWWTADAHPGRVRTLTVVSTPHPGALATTLRTDPDQRERSRYMIDWREAPATEERMLA
                     GDAEELRATYAGKIPQDSAEAYVRHLSQPGALTAALNWYRAGRPDDAIGFIDVPTLYVW
                     STEDSAFGPVAAQETGRWVNGPYRFEILEGVSHWVPEEAPETLSRLLLEHLRAHGEHGT
                     TASTTSVDSQKR"
     aSDomain        695..1408
                     /aSDomain="Abhydrolase_1"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S1361_RS01380_Abhydrolase_1.1"
                     /evalue="2.20E-34"
                     /label="S1361_RS01380_Abhydrolase_1.1"
                     /locus_tag="S1361_RS01380"
                     /protein_end="262"
                     /protein_start="24"
                     /score="111.1"
                     /tool="antismash"
                     /translation="PVLLLHGFPQTGLVWRRQIAALAKHGYRVVAPDQRGYSPRARPER
                     PEAYRIGLLVEDVVAITEELGWAAFDLVGHDWGGAVAWWTADAHPGRVRTLTVVSTPHP
                     GALATTLRTDPDQRERSRYMIDWREAPATEERMLAGDAEELRATYAGKIPQDSAEAYVR
                     HLSQPGALTAALNWYRAGRPDDAIGFIDVPTLYVWSTEDSAFGPVAAQETGRWVNGPYR
                     FEILEGVSHWVPEEAP"
     gene            1671..2330
                     /locus_tag="S1361_RS01385"
                     /old_locus_tag="S1361_01370"
     CDS             1671..2330
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003994671.1"
                     /locus_tag="S1361_RS01385"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01370"
                     /product="hypothetical protein"
                     /protein_id="WP_243769023.1"
                     /transl_table=11
                     /translation="MISTFYNFNPDFVRKAVEGAWDAATPQQVLDARHAGASEALRRAG
                     IHELPALDEVVALTRRAAEAACEHVQGRPLFAAHAALPWPEEPVLQLWHAQTLLREFRG
                     DGHVACLLSEGVGGLESLILHAATGEVPVDFLKASRAWPEDEWADTAERLRSRGLLDGD
                     ALSPEGVRLRQHIEDRTDRLSLPAYTALGDADCERLAELASPFGRKVVDAGLLKVG"
     gene            complement(2784..3398)
                     /locus_tag="S1361_RS01390"
                     /old_locus_tag="S1361_01375"
     CDS             complement(2784..3398)
                     /EC_number="3.-.-.-"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027: isochorismatase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014155478.1"
                     /locus_tag="S1361_RS01390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01375"
                     /product="isochorismatase family cysteine hydrolase"
                     /protein_id="WP_208030018.1"
                     /transl_table=11
                     /translation="MTEKLQLDPARTAIVLIEYQNEFTSVGGVLHEAVADVMRRTGMLA
                     NTVALVDAARRAGVSIMHAPITFAEGYGELTRHPYGILKGVVDGKAFVKGTWGASIVDE
                     LTPANGDIVIEGKRGLDTFASTNLDFILRSKGIDTIVLGGFLTNCCVESTMRTGYEHGF
                     RVITLTDCVAATSQEEHDNAISYDFPMFSLPRTSADVIAAL"
     gene            3509..4210
                     /locus_tag="S1361_RS01395"
                     /old_locus_tag="S1361_01380"
     CDS             3509..4210
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1071: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003987606.1"
                     /locus_tag="S1361_RS01395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01380"
                     /product="FCD domain-containing protein"
                     /protein_id="WP_208030019.1"
                     /transl_table=11
                     /translation="MTISPVSRVPLSLEVAQRLRAAILDGTFPADTELPTETELAQSFG
                     VGRSTIREALRVLQAHGLISGADTVSTARPRVTHERTAGAAGLALSTALQVGAIPLADL
                     VALRTLLEAEAIRQTTSVPEAARSCLLTMAAAVDNADIHTFHAADVDFHVQLAYAGGNQ
                     ALGFVIGVLRDCIAGYLLDALAAVADRGTMLARLLAEHQSIVDALDAGEPDRAAELVVA
                     HIRGFYEPETS"
     gene            4264..5577
                     /locus_tag="S1361_RS01400"
                     /old_locus_tag="S1361_01385"
     CDS             4264..5577
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1261: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982824.1"
                     /locus_tag="S1361_RS01400"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01385"
                     /product="FAD-linked oxidase C-terminal domain-containing
                     protein"
                     /protein_id="WP_243769024.1"
                     /transl_table=11
                     /translation="MVTDRDAMEAYRRDQCLLAPAGRPAAVVRARSTDDVITTLRTAGD
                     HHAPVVTRGAGTGLAGAANAIDGCVVLSLAAMDRILALDVPGRTATVEPGVLTGDLDAR
                     AREHGLWYPPDPGSKAISTIGGNLATNAGGMCCAKYGVTADHVAALTAVLADGRVIRTG
                     PPTRKNVTGLDLTRLLVGSEGTLAVIVDATVRLRPFPAATATVVASFPTPQQAVDTVLR
                     IASVADPAAVELMDRTCMRAVNRLTRMGLDESAGALLLVQCDGPSADQEAATCARLAET
                     GGATEVLHTADPTEGEMFMQARRTVYPALERLGTTLLDDVGVAVQDLPRLLAAIERIAA
                     DHGVLIGTFGHAADGNLHPTVVYDATDRDAADRAGAAFDDIVAAALALGGTITGEHGVG
                     SLKTRYLDAQLGPTERELMTGIRAVFDPGGILNPGRGY"
     gene            5724..6836
                     /locus_tag="S1361_RS01405"
                     /old_locus_tag="S1361_01390"
     CDS             5724..6836
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_010982823.1"
                     /locus_tag="S1361_RS01405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01390"
                     /product="catalase family protein"
                     /protein_id="WP_208030021.1"
                     /transl_table=11
                     /translation="MKPVRYEEYRPTERPSYHEELEAVVAQVARRTRASVEREAVGRAV
                     RAAHGKTYGLLKATVTVGDNAGFYGQGIFARPTAYEAVVRYSNGLGHHRPDHQLGAACG
                     MGIKLFGVAGPSLLDDERDSGTFDLNLINNEVFFANTAYDYMVIEDLFAELPEALVDPA
                     RRKTWMAEFLTRRHTLTDPDNWLWDELLAMLSFTAVPRRNLLSYTYNSMGAFRYGDHIA
                     KIRTVPTAASLASLTHQIVDVRADNEAFRHTLVAEAAERDHSFELQVQLNTDLARMPVD
                     NTSVKWPEDLSPWVTVARVDLPRQDIGGKDNLAAADATSITPWRSREEHRPIGEIQRVR
                     QEVYRRSSIERHRINGQERREPAGSAELLG"
     gene            complement(7039..8136)
                     /locus_tag="S1361_RS01410"
                     /old_locus_tag="S1361_01395"
     CDS             complement(7039..8136)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014142956.1"
                     /locus_tag="S1361_RS01410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01395"
                     /product="DUF3533 domain-containing protein"
                     /protein_id="WP_243769025.1"
                     /transl_table=11
                     /translation="MSAESPSTSAAPAGGFLAELRDAVSFRAFGLVLGGLLIQLAFTVS
                     YLGAFHSPTPHRIPVAVVAPGEASVQIVAKLNGLDGDPVKATAVAGESAARERIMDRRA
                     DAAFLFNATGTKDTLLVASAGGPSVSQTASQLAQRIEAGQKRQVVVTDIRAPNSGDGRG
                     MTSFYLVLGWVVGGYLTATIMNMSAGSRPANRHRITIRLAVLGLYAIVSGVAGAVIVGP
                     VFDALSGHFWALTGIGTLVVFASAATSLALQTLLGMLGTGVTILLFVVLGNPSSGGVYP
                     SVLLPGFWSAIGQALPPGAGTTLVRNTVYFGAHATSIAWSVLAAYAVGGAAVALVAAWW
                     RERRKAAAVGAVGSDGSGPDPAPAG"
     gene            complement(8249..8932)
                     /locus_tag="S1361_RS01415"
                     /pseudo=""
     CDS             complement(8249..8932)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002617905.1"
                     /locus_tag="S1361_RS01415"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MVWWRAKRQPRPWVVSDELWSLVEPLLPEPGPKWLSGCSRVP"
     gene            10001..11200
                     /locus_tag="S1361_RS01420"
                     /old_locus_tag="S1361_01415"
     CDS             10001..11200
                     /EC_number="4.2.3.-"
                     /GO_function="GO:0030554 - adenyl nucleotide binding
                     [Evidence IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /GO_process="GO:0017000 - antibiotic biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     amglyccycl: salQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DHQ_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1183: 3-dehydroquinate synthase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742208.1"
                     /locus_tag="S1361_RS01420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01415"
                     /product="sedoheptulose 7-phosphate cyclase"
                     /protein_id="WP_208030022.1"
                     /sec_met_domain="salQ (E-value: 3.7e-147, bitscore: 488.8,
                     seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="DHQ_synthase (E-value: 2.5e-60, bitscore:
                     202.7, seeds: 76, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPRQQSWKIQAELPVEYEIIESHGLLDPDNPDLLRLPGGRRGTGT
                     RLVVLDHSVDELYGAEIRSYFSKNKVVVDYLTLPGSEENKSIERVLEVVNKLNEVGTNR
                     LSSPPIVIGGGVVADVVGLAASLYRRGIPFVRVPTTLLGQVDVSVAAKSGINYGGYRNR
                     LGAYTPPPRTLIDRRFLATVPDRQLRNGMGEIFKMALIKDLRLFELLEEYGAELIETRF
                     QDPRAGSTGLPGTVADEVIGRAIAGMAEELQPNLWEKDLQRSVDYGHSFSPLVEMRALP
                     ELLHGEAVAMDCIFSALIAADRGLIDDAQLERIIAVARRMGLEPSHPLFCDVALVLDGL
                     ADTVRHRDGRQNLPMLTGIGQVCFLNDVTENEIERACAGMGGLLDANAGRPGQRIGSDL
                     "
     misc_feature    10037..10039
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            11197..11976
                     /locus_tag="S1361_RS01425"
                     /old_locus_tag="S1361_01420"
     CDS             11197..11976
                     /NRPS_PKS="Domain: PKS_KR (14-167). E-value: 1.6e-18.
                     Score: 59.2. Matches aSDomain:
                     nrpspksdomains_S1361_RS01425_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024950.4"
                     /locus_tag="S1361_RS01425"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01420"
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_208030023.1"
                     /sec_met_domain="adh_short (E-value: 6.6e-39, bitscore:
                     132.5, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.8e-31, bitscore:
                     106.9, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEGTGARDSVEGKVVVVTGGSSGIGRASAAVFAEAGMRVVIAAR
                     NEERGAEAAHEIRSRGHEACFVRCDVTSPDQVRNLFARVVQQYGRVDCAFNNAGVSGDG
                     RLADLTPQDFDRAFAVNTRGLWLCMREELRLMSAQEDGGSIVNNTSVHGIRTIFPGIGA
                     YVASKHAAVALTRMAAMEHAREGVRVNAVAPGPVESEMLAASEAAVGGATTWRRLIPSG
                     EIGTPRQVADVALWLFSAASSYVNGQAVGVDGGFLAT"
     aSDomain        11239..11697
                     /ASF="KR domain putatively catalyzing D-configuration
                     product formation"
                     /ASF="catalytic triad S,Y,N inconclusive"
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_S1361_RS01425_PKS_KR.1"
                     /evalue="1.60E-18"
                     /label="S1361_RS01425_PKS_KR.1"
                     /locus_tag="S1361_RS01425"
                     /protein_end="167"
                     /protein_start="14"
                     /score="59.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="VVVVTGGSSGIGRASAAVFAEAGMRVVIAARNEERGAEAAHEIRS
                     RGHEACFVRCDVTSPDQVRNLFARVVQQYGRVDCAFNNAGVSGDGRLADLTPQDFDRAF
                     AVNTRGLWLCMREELRLMSAQEDGGSIVNNTSVHGIRTIFPGIGAYVAS"
     CDS_motif       11242..11325
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_S1361_RS01425_0001"
                     /evalue="4.40E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="S1361_RS01425"
                     /protein_end="43"
                     /protein_start="15"
                     /score="16.2"
                     /tool="antismash"
                     /translation="VVVTGGSSGIGRASAAVFAEAGMRVVIA"
     gene            12022..13554
                     /locus_tag="S1361_RS01430"
                     /old_locus_tag="S1361_01425"
     CDS             12022..13554
                     /GO_function="GO:0016614 - oxidoreductase activity, acting
                     on CH-OH group of donors [Evidence IEA]"
                     /GO_function="GO:0050660 - flavin adenine dinucleotide
                     binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742206.1"
                     /locus_tag="S1361_RS01430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01425"
                     /product="GMC family oxidoreductase N-terminal
                     domain-containing protein"
                     /protein_id="WP_208030024.1"
                     /transl_table=11
                     /translation="MQSFTPYDFIVVGAGAAGSVVAARLSEDPARSVLLLEAGPPDSDP
                     RIARPASWPMLLGGELDWGYRTVPQRALHGRRLAWPRGRVVGGSGSINAMVHIRGAASD
                     FDAWQHWGGDTWNAQHLLPYLEGLEGPAHAAPYGSLPVAENTDPHPFAAAFVEAAQKYG
                     LPGNPDFNAGRQEGVGLYRTTRTSGTPGAPARRGSTARTHLGPALQRPNLTLVTDAAVL
                     GLVTDGDRVTGVRVRHDGTVTSVACTTEVVVCAGAVASPQLLLLSGLGPAADLRALDIP
                     VTVDLPGVGANLHDHVQVSLAYDTAEGHPVADSSNLGEAGGFVRLDSTAAEPEVQLSFA
                     PMKDLNHADRLGHGFTIGPGVTRPVSRGRLTLGSADPDAHPLIDPAYLTDAADMDVLAE
                     GVRIARDIAATDPLARLTTGRAPLGARATRRETEEFVRANAQTQFHPVGTCRIGLDGDS
                     DAVVDPRLRVRGTSGLRVADASVIPTMITGNIHAAVAAVAERAARFIQDDHA"
     gene            13568..14608
                     /locus_tag="S1361_RS01435"
                     /old_locus_tag="S1361_01430"
     CDS             13568..14608
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016651 - oxidoreductase activity, acting
                     on NAD(P)H [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GFO_IDH_MocA_C3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079: oxidoreductase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742205.1"
                     /locus_tag="S1361_RS01435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01430"
                     /product="Gfo/Idh/MocA family oxidoreductase"
                     /protein_id="WP_243769026.1"
                     /sec_met_domain="GFO_IDH_MocA (E-value: 6.6e-23, bitscore:
                     80.5, seeds: 39, tool: rule-based-clusters)"
                     /sec_met_domain="GFO_IDH_MocA_C3 (E-value: 2.9e-23,
                     bitscore: 81.0, seeds: 4226, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAHDERDSTLRWGVLGATSYIATHLIPAITATHGCALTAVASRP
                     ERAAAAAELGRAHGATVHPDYRALIADPAVDAVYIPLPNTQHVDWTLRALEAGKHVLVE
                     KPMAMDEEDCARIEKAAEAASRTVMEAFMYRFHPQQRRAAEILASGKIGELRGVRASFA
                     FRIESGSGNIRLDAALGGGATWDVGCYAVDVPLFFFGRAPGQVSAHFSSRPGLAVDTSA
                     VATMDFGQGHFAVVDYSIDYGPRAAYELQGTRGTLMVRNAWAMDGEDGVVTVLTEDGVH
                     EETVPSANHYQLQVEAFAAAVRDGAPAPVPLADSRRTARVGRAFVASAAAGGAAVVTSA
                     QETEGR"
     gene            14605..15930
                     /locus_tag="S1361_RS01440"
                     /old_locus_tag="S1361_01435"
     CDS             14605..15930
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0051119 - sugar transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1169: sugar
                     transport protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:TIGR00879.1"
                     /locus_tag="S1361_RS01440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01435"
                     /product="sugar porter family MFS transporter"
                     /protein_id="WP_243769027.1"
                     /transl_table=11
                     /translation="MIPTRSPAAARTLTVCVASVGGLLFGYGTGVIAGALPLVTAEYGL
                     SSWSQGAAVSAALLGAALTAPSSGRLADRFGRLPVIGTAAGVYAVGSLASAAATGAASL
                     LAGRFLVGLSLGATSFAVPLYISEIAPPARRGALVTLNQLMITIGLLLSYVVAYALEPA
                     GAWRWMLGVGIVPALLLLAGTCLVHESPDWLRSRGHDARAALSAARLGLGPVDGPAPVT
                     VRRGIGLRPACALAGRRWVALGLAIAVLVHLTGLNTAVYYAPTILASGGLTPAGGIVGS
                     ILVGLCNVMATVITVLFLDRWGRRPLMIGGLVVMAFTAVAIAAAELSGDRGAVAALLLC
                     LFITAGAVGPAAVFWVYIAEIYPSQARGALMSLATAAHWAADFVVATTFLPLVQHLSLA
                     GTFALYAGITGASALALARYMPETRGRPLVAAAQPASVRVAE"
     gene            16058..16672
                     /locus_tag="S1361_RS01445"
                     /old_locus_tag="S1361_01440"
     CDS             16058..16672
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1115: HAD-superfamily hydrolase, subfamily IA,
                     variant"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008742203.1"
                     /locus_tag="S1361_RS01445"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01440"
                     /product="HAD family phosphatase"
                     /protein_id="WP_208030025.1"
                     /sec_met_domain="HAD_2 (E-value: 1.8e-27, bitscore: 95.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHPDLSPRHASCLLFDWDGTLVDSQYANYRAMAAVLSSEGVDLEQ
                     AWFDARTGLSSAEMIRTLVDERSLRLSRPVEDLVADRDRMFLEEAHTVRPHQEVLQVVE
                     AMRGRVPMAVASGGARHVIEATLRHQPFHSHFDALVTRDDVDRGKPAPDIFLHAAELLG
                     AHPSRCTVYEDSDEGVEAAHAAGMTVIDVRPYTRLRFRSGT"
     gene            complement(16834..17373)
                     /locus_tag="S1361_RS01450"
                     /old_locus_tag="S1361_01445"
     CDS             complement(16834..17373)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS01450"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_01445"
                     /product="hypothetical protein"
                     /protein_id="WP_208030026.1"
                     /transl_table=11
                     /translation="MRLTGRTTTPAGRRSAAIGVGAAAIALAGASLAAPAAAQERAAAP
                     AGTYCGPTESFYGNGQWTYAEVQLCLQADSSGAVSVVVNTRQVQYYWGSAWYYASSGSP
                     ASWDAKGAAGVGGTSHSYGVSGRQTSAAGSASAALSTTVCGTYSVTMTYHQVGPYWGSD
                     QALDSGQRTYSINVPC"
     misc_feature    complement(17596..17610)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 18.75"
                     /tool="antismash"
     misc_feature    17596..17611
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.54"
                     /tool="antismash"
     misc_feature    complement(17597..17610)
                     /note="TFBS match to LexA_variant_2, Repressor of DNA
                     damage response, confidence: weak, score: 19.77"
                     /tool="antismash"
     gene            complement(17609..17770)
                     /locus_tag="S1361_RS40015"
     CDS             complement(17609..17770)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF044287.1"
                     /locus_tag="S1361_RS40015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_341829366.1"
                     /transl_table=11
                     /translation="MVRARLLTLGHDVVSLAHEALITAWPRLHPWIDTDREHPRIHRSL
                     NHWPRSPG"
     gene            complement(17847..18449)
                     /locus_tag="S1361_RS01455"
                     /old_locus_tag="S1361_01450"
     CDS             complement(17847..18449)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018541849.1"
                     /locus_tag="S1361_RS01455"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01450"
                     /product="hypothetical protein"
                     /protein_id="WP_208030027.1"
                     /transl_table=11
                     /translation="MDVPKLLEAASLLVPEAVATENDITVNDVWEYLVHDEWEVALDLL
                     EELGDVHPLPLAFWQTLATAAEQLRLDRSAAWCHWRCFETRNGIIRADLTLRPADEARR
                     QTPFSGAGVLRPMWNTGGKLPTAEPDLHIAALWVEFTPFMEPGGQATVRLAPLSPSKWQ
                     QLQTGQVITMHEDRTVAGTAVVLEIQGPPAPPATLQS"
     gene            complement(<18459..>18559)
                     /locus_tag="S1361_RS01460"
                     /pseudo=""
     CDS             complement(<18459..18559)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019891874.1"
                     /locus_tag="S1361_RS01460"
                     /note="frameshifted; incomplete; partial in the middle of a
                     contig; missing N-terminus and C-terminus; Derived by
                     automated computational analysis using gene prediction
                     method: Protein Homology."
                     /product="AAA family ATPase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLPSCEGSRRDSLSA"
     gene            18706..19251
                     /locus_tag="S1361_RS01465"
                     /old_locus_tag="S1361_01455"
     CDS             18706..19251
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014158142.1"
                     /locus_tag="S1361_RS01465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="S1361_01455"
                     /product="hypothetical protein"
                     /protein_id="WP_208030028.1"
                     /transl_table=11
                     /translation="MAFGEHVERVAAEVVGEFPADSGIYAVTFRIDSVDQDPRLPYLAI
                     GYTTEADATAAAQQTPDAWEARWSYAFFPETGLEGVRTVGRDPDGARSHRREAEARGLW
                     YEDDDEADGRDERLVEWFYEVCVAAARRLHDSGRIVAVLGRPVPVILYDMFDPDAMFEL
                     TSSANPADLVADFMAEAP"
     gene            19571..20437
                     /locus_tag="S1361_RS01470"
                     /old_locus_tag="S1361_01460"
     CDS             19571..20437
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="S1361_RS01470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="S1361_01460"
                     /product="PD40 domain-containing protein"
                     /protein_id="WP_208030029.1"
                     /transl_table=11
                     /translation="MTVPLTLNAAGDAGAAADHPIVFARYTAGAPVEDLYAISAGGGTP
                     VKLTHTSTVSDVMPSWSPDGKRVAFVRYGSGGAIDGVWTMKTTGGDLKAVPGTKGASDP
                     AWSPDGKRIAYAKPVGTQREIYVADIDGTPATRLTHTAADDLHPTWSPDGKYLAFNRAD
                     AGGHSRVMRIRLSTLAQTAVTGSGSHDWTPDWSHGNRIVFSRVDSSGFAHLYLVRPDGT
                     GVHRITSSRFNDKYPSWSPDGSRLVFTRGGTDDADPEHLYLVRADGTGTTKLTKTDSHD
                     MEADWRP"
     misc_feature    complement(20818..20834)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: weak, score: 19.59"
                     /tool="antismash"
ORIGIN
        1 ccgacgacga cctgcatgcc gtcgccgacg atctgcttgg cggccgtcgc aatcgccatc
       61 aggcccgacg aacactgccg gtcgatcgtc atcccggaca cggtgtccgg aagaccggca
      121 cggagggcgg cctggcgggc gacgttgcca ccggaggacc cctgctgcag ggcgcagccc
      181 aagatcacat cctcgacctc acccccctcc agcccggcgc gctgcactgc gtgcgagagg
      241 gcgtgggcgg cgagttcctg cgcctgggtg tcgttgaacg caccgcggta cgccttcccg
      301 atcggcgtcc tcgccgtcga aacgatgact gcttccctca tgtcgcctca cttcttcccc
      361 tgtcggcatt cgtccgggag cttcggggct ggaatccgga gcaccgtgag gcgcgccgac
      421 aggcgccgcg gcccgtgcgg aggacgggag ccatcctccc ggccgtttat agttgaagtc
      481 ggcgtcaagt tcaatcgtgt ctcctcgtgc ggcgcacggc tgcgactgcc ggggacggcc
      541 ggggatgcgc acaccctcac cttgacaatc cacctccacg gctgaaggct gaccgaccag
      601 tcggtacgaa gggtcggaac gcatgaccga gctgagcatc tccactgctg cgggcgtgtt
      661 cgacgcgatc gtggcgggtc cgcccgaggg ccgccccgtg ctgctgctgc acggtttccc
      721 gcagaccggg ctcgtgtggc gacggcagat cgcggcgttg gcgaagcacg gctaccgggt
      781 ggtggcaccc gaccagcgcg ggtactcccc cagagcccgg cccgagcggc ccgaggccta
      841 ccgcatcggc ctcttggtcg aggatgtcgt cgcaatcaca gaggaactgg gctgggcggc
      901 tttcgacctg gtcggccatg actggggagg cgcggtggcg tggtggaccg ccgatgccca
      961 ccccggccgc gtacgtactc tgacggttgt ttccaccccg caccccggcg cactggccac
     1021 caccctgcgc accgacccgg accagcggga gagatcgcgc tacatgatcg actggcgcga
     1081 agcgcccgct accgaagagc gcatgctcgc gggcgatgcc gaggagcttc gcgccaccta
     1141 cgccggaaag atcccgcagg acagtgccga ggcctatgtg cggcacctgt cccagccggg
     1201 cgctctcacc gcggcgctga actggtacag ggccggccgc cccgacgacg cgatcggctt
     1261 catcgacgta ccgacgctgt acgtctggag cacggaggac agtgcgttcg gcccagtcgc
     1321 cgcgcaggag acggggcggt gggtcaacgg gccgtaccgt ttcgaaatcc tggagggcgt
     1381 cagccactgg gtccctgagg aagcgcccga gacgctgagc cgcctgctgc tcgaacatct
     1441 gcgagcgcac ggcgagcacg gaaccacagc gagtaccacg tctgtcgact ctcagaagag
     1501 gtgaccttgt gaagacagcg cgagcagcct ggcgccggct agagcccgta cacgcgatga
     1561 tctacttcgc ccccgaggca aggcgacggt acgcggacct cggactcagc ggacgcgccg
     1621 ggtacttcgc ctcccggggc gccgccttcg gccgagcatc tgccgatctg gtgatctcga
     1681 ccttctacaa cttcaacccc gatttcgtac ggaaggcggt cgaaggggcc tgggatgcgg
     1741 cgacgccgca gcaggtgctg gacgcgcggc acgccggcgc gagcgaggct ctgcgacggg
     1801 cggggatcca cgaactcccc gccttggacg aggtcgtggc gttgacccgc agggccgccg
     1861 aggcagcctg cgagcacgtg cagggccgcc cgctgttcgc cgcacatgcc gcgctgccct
     1921 ggccggagga accggtactg caactgtggc acgcccagac attgcttcgg gaattccgtg
     1981 gagacggcca tgtcgcgtgc ttgctgagcg agggcgtagg gggcctggag tccctgattc
     2041 tgcacgctgc cactggtgag gttcccgtcg acttcctcaa ggcgagccgc gcatggcccg
     2101 aggacgagtg ggccgacacc gccgagcgcc tgcgctcgcg aggtctcctc gacggcgatg
     2161 ccctcagccc ggaaggcgta cgcctgcgcc agcacatcga ggaccgcacc gaccgcctga
     2221 gccttcccgc ctacaccgcg ctgggtgacg ccgactgcga acgcctcgcc gaactcgcga
     2281 gccccttcgg ccgcaaggtc gtcgacgccg gcctcctcaa ggtcggctga cctagccctt
     2341 caaggtgagt cgtccggtgc ggaggcatga aggaagggcc tcttggtagc tcgcggttgt
     2401 cgagtccagc gagtgacaag aggccctggt gttgcagtgt cgcgtggtgg tggctgacgg
     2461 gtccggtcgg tctactcgtg ggtgcgactg tctcgcccac agttcgggaa tgcggccgac
     2521 cagccggtcg acaacggcgt caagtggcgg gcgatgccct gggtaaccca cgcctcagtc
     2581 agagcccggg gcggtgtcca gtcgcagtcc cgacctgaaa agccctcgaa tgcgccgaac
     2641 cgtggaccca tcacggcgcc tgcgccgtgg acaccgccga gtggagctgc accgcttcgg
     2701 agctccccgg cgcggccacc accgcaccgc ctggagggtg agcgccggtg ggtctcccgg
     2761 cttgcgacgc aacggcaggt ggactacagg gcggcgatga cgtcggcaga ggtcctcggc
     2821 agcgagaaca tcgggaagtc gtaggagatg gcgttgtcgt gctcctcctg cgaggtggcg
     2881 gcgacgcagt cggtcagggt gatcacccgg aagccgtgct cgtaaccggt gcgcatggtc
     2941 gactccacgc agcagttggt gaggaagccg ccgaggacga tcgtgtcgat gcccttgctg
     3001 cgcaggatga aatcgaggtt ggtgctggcg aaggtgtcga gcccgcgctt gccctcgatg
     3061 acgatgtccc cgttcgccgg cgtgagctcg tcgacgatgg aggcgcccca cgtgcccttg
     3121 acgaacgcct tcccgtcgac gacgcctttg aggatgccgt acgggtgccg ggtcagctcg
     3181 ccgtagcctt ccgcgaacgt gatcggcgcg tgcatgatcg acactccggc ccgccgggcg
     3241 gcgtcgacca gggcgacggt gttggcgagc atgccggtgc gccgcatgac gtcggcgacc
     3301 gcctcgtgca gtacgcctcc gacgctggtg aactcgttct ggtactcgat gagcacgatc
     3361 gcggtcctgg ccgggtcgag ctggagcttc tcggtcatgg cgacacctga cttccgcgtc
     3421 cttgagggag tggccctctg tgtcctgggc ccagcgagaa gcaccctagc tgcttgtccg
     3481 acaaacagac aaggactagg gtgcggccat gacgatctca ccggtctcgc gcgtgcccct
     3541 gagtctggag gtggctcagc gcctgcgggc ggccatcctc gacggcacgt tccccgccga
     3601 caccgagctg cccacggaaa ccgaactcgc ccagtccttc ggtgtcgggc ggtccaccat
     3661 ccgcgaggcg ctgcgggtgt tgcaggcgca cggtctgatc agcggagcgg ataccgtttc
     3721 caccgcgcgc ccgcgcgtca cccacgagcg cacggcgggc gcggcgggcc tggccttgag
     3781 cacggcgctg caggtcggcg cgatcccgct ggccgacctg gtggcgctgc gcaccctgct
     3841 ggaggcggag gcgatacggc agaccacgtc cgtgccggag gcggcccggt cctgtctgct
     3901 gaccatggcg gcagcggtgg acaacgccga catccacacc ttccacgccg ctgacgtgga
     3961 cttccacgtg cagctcgcct atgccggtgg taatcaggcg ctggggttcg tcatcggtgt
     4021 gttgcgcgac tgcatcgccg gctacctgct cgacgcgctc gccgcggtgg ccgatcgagg
     4081 aacgatgctc gcgcgtctgc tggccgaaca ccagtcgatc gtcgacgcgc tggacgcggg
     4141 cgagcccgac cgtgccgccg agctggtcgt cgctcacatc cgcggtttct acgagccgga
     4201 gacgtcatga ccgaggttgt cgatgacgtc gccgccgccc tcgccgccgc gctgccgggc
     4261 cgggtggtca ccgaccggga cgcgatggag gcctaccgcc gtgaccagtg cctgttggct
     4321 cccgcgggac gcccggcggc ggtggtgcgt gcccgctcga ccgatgacgt gatcaccacg
     4381 ctgcgcacgg ccggcgacca tcacgccccg gtggtgacgc ggggggccgg caccgggctg
     4441 gcaggcgcag ccaatgcgat cgacggctgc gtcgtactct cgctcgccgc gatggaccgg
     4501 atcctcgccc tggacgtgcc cggccggacg gcaaccgtcg agccgggcgt gctcaccggc
     4561 gatctcgacg cccgcgcccg cgagcacggc ctgtggtatc cgccggaccc gggaagcaag
     4621 gcgatctcca ccatcggcgg caacctggcg accaacgcag gcggcatgtg ctgcgccaag
     4681 tacggggtca ccgccgacca tgtcgccgcg ctgacggccg tactcgccga tggccgcgtg
     4741 atccgtaccg gtccgccgac ccgtaagaac gtcaccgggc tcgacctcac ccggctcctc
     4801 gtcggctccg aaggcacgct cgcggtgatc gtggacgcca ccgtgcgact gcggccgttc
     4861 ccggcggcca ccgctaccgt ggtggcctcg ttcccgacgc cccaacaggc ggtcgacacc
     4921 gtgctgcgga tcgcgtcggt cgccgacccg gcggcggtgg agctcatgga ccgcacgtgc
     4981 atgcgcgccg tcaatcgcct gacgcgcatg gggttggacg agtcggccgg ggcactcctg
     5041 ctcgtccagt gcgacgggcc gtccgccgat caggaggccg ccacctgtgc caggctggcc
     5101 gaaaccggcg gcgccaccga ggtgctgcac accgccgacc ctacggaagg cgagatgttc
     5161 atgcaggcca gacgaacggt gtacccggct ctggagaggc tgggtaccac gttgctggac
     5221 gacgtcggtg tcgcggtcca ggaccttccc cgattgcttg ccgcgatcga gcggatcgcc
     5281 gccgaccacg gcgtgctgat cggcaccttc ggccacgccg ccgacggcaa cctgcatccg
     5341 accgtcgtct atgacgccac cgaccgagac gctgccgacc gtgccggtgc cgctttcgac
     5401 gacatcgtgg ccgccgccct cgcgctcggc ggcacgatca ccggcgagca cggcgtgggc
     5461 tcgctcaaga cacgctacct cgacgcacaa ctcggtccca ccgagcggga gttgatgacc
     5521 ggcatcaggg ccgtcttcga tcccgggggc atcctcaatc cgggccgcgg gtactgaagc
     5581 gtcttctcca ttcggccgag ggcatgttcc gcgcggctgc gcggtgggcg gtgaaggtgc
     5641 gattgcccac agcaagatag attgtgcaca actgaattgc gggctagcgt ttgggcagta
     5701 ccccacgaca gggaggcggc acaatgaagc ccgtccgcta cgaggaatac cgtcccaccg
     5761 aacgcccgtc ctaccacgag gagctggagg cggttgtcgc ccaggtggcg cgccgtactc
     5821 gcgcctcggt cgagcgcgaa gccgtcggcc gagctgtccg cgctgcccat ggaaagacct
     5881 acggcctcct caaggccacg gtcacggtgg gtgacaacgc aggcttctac gggcagggaa
     5941 tcttcgcccg gccgaccgcg tacgaagccg tcgtccgcta ctcgaacggc ttgggccacc
     6001 accgccccga ccaccagctg ggcgcggcgt gcggaatggg catcaagttg ttcggagtgg
     6061 ccggcccctc actgctggac gacgaacgag acagcggcac cttcgacctc aacctgatca
     6121 acaacgaggt cttcttcgcg aacaccgcct acgactacat ggtgatcgag gatctgttcg
     6181 ccgaactgcc cgaggccctg gtggacccag cccgccgcaa gacctggatg gcggagttcc
     6241 tgacccgccg gcacacgctc accgatcccg acaactggct gtgggacgaa ctgctcgcca
     6301 tgctgtcgtt caccgccgtc ccgcgcagga acctgctgtc gtacacctac aacagcatgg
     6361 gcgccttccg gtacggcgac cacatcgcca agatccgtac cgtgccgaca gcagcctccc
     6421 tggcctccct cacgcaccag atcgtggacg tgcgcgcgga caacgaggca ttccgtcaca
     6481 ccctggtggc cgaggccgcg gagcgagacc actccttcga gctgcaggtc cagctcaaca
     6541 ccgatctggc gcggatgccg gtggacaaca cgtccgtcaa gtggcccgag gacctgtccc
     6601 cctgggtgac ggtcgcccgt gtggatctcc cacgccagga catcggcggg aaagacaacc
     6661 tggccgccgc cgacgccacg tcgatcacgc cgtggcgatc acgcgaggag caccggccca
     6721 tcggcgagat ccagcgggtg cggcaggagg tgtaccggcg ctcgtccatc gaaaggcacc
     6781 gcatcaacgg acaagagcgg cgcgaaccgg cgggcagcgc cgagctgctg ggctgagctt
     6841 tccgctccgg ccgtgcccgg acgggtccgg gcacgatccg gcgccgaccc ggtgtacccc
     6901 ggggctcgcc cccatgccgg ggcagtcgcc gttgtgccgc agaagcgtcc tggccgtcgg
     6961 cccgacgagg acgacggttc gcacagcagc cacatcgcca cctggttcat ggggcggtcg
     7021 cgccggtcgg cacggccgtc accctgcagg tgcggggtcc ggtccgctgc cgtccgatcc
     7081 aacggcgccg acggccgccg ccttgcgccg ctcccgccac caggccgcga ccagcgcgac
     7141 cgcggcaccg cccaccgcgt aggcggcgag caccgaccag gcgatcgatg tggcgtgcgc
     7201 gccgaagtac acggtgttgc ggaccagcgt ggtgcccgcg cccggcggca gtgcctgtcc
     7261 gatcgcgctc cagaaccccg gcagcagcac cgacgggtac accccgcccg agctcggatt
     7321 gcccagcacc acgaacagca ggatggtcac cccggtgccg agcatgccca gcagcgtctg
     7381 cagcgcgagt gaggtcgccg ccgacgcgaa caccaccagc gtgccgatcc cggtcagcgc
     7441 ccagaagtga ccactcagtg cgtcgaacac cgggcccacg atcaccgcgc cggcgacccc
     7501 ggacacgatc gcgtacaaac cgagcaccgc cagcctgatc gtgatccggt gccggttggc
     7561 cggtcgtgaa ccggcggaca tattcatgat cgtcgccgtc agatagccgc cgaccaccca
     7621 gccgagcacc aggtagaagg aggtcatgcc gcgcccgtcg ccgctgttcg gggctcggat
     7681 gtcggtgacc acgacctgcc gcttctgccc ggcctcgatc ctctgggcga gctgtgaggc
     7741 ggtctgtgac accgaggggc cgcccgccga ggcgaccagc agggtgtcct tcgtgccggt
     7801 cgcgttgaac aggaacgcgg catccgccct acggtccatg atccgctccc gggcggcgga
     7861 ctcgccggcg acggcggtcg ccttcaccgg gtcgccgtcg agcccgttga gcttggccac
     7921 gatctgcacc gacgcctccc ccggggccac caccgccacc ggaatccggt gcggggtggg
     7981 agagtgaaat gcgcccaggt aggagacggt gaaggcaagt tggatcagca ggccgccgag
     8041 tacgagcccg aaggcgcgga agctgacggc gtcgcgcagt tcggccagga aacccccggc
     8101 tggggcggcg gaggtggagg gagattcggc gctcatggca cgcatgtacc ccggatgacc
     8161 cggtacaccg aacgcggtgt ggatctccga cttggcgtac tgcgggggtt tgttcccagt
     8221 catgtcacgc ggactcgcct gacaacggct aacaccatga ctggagttgt cggtgggtga
     8281 tcaggcggca ggcgagttcg aggaacgctt cgtggatgtc gtctcgtcgc tcccagcgga
     8341 tccgcaggca ccggaagccg tggaaccgcg agatcgtccg ctcgacgacc cggcggaagg
     8401 tgcccaggcc cgtgccgtgc tgcgggccgc gttcggcgat cacgggtcgg agccccgctg
     8461 ccacagcagc caccggtact tgtcgtggtc ggagccgcgg tcggcgaaca gcatgtcggg
     8521 ccggcgtatg ggccggccga cggcgccggc cacggccggg accttgtcca gcagcggcag
     8581 caactgggtg acgtcgttgc gatttccgcc ggtcagcgag accacgagcg ggatgccctg
     8641 cccgtcggtg aggatctggt gcttgctgcc cgcccgtggg aggaatcgat caccgcccgc
     8701 gaccagttca ggttcttcgc cgaccgcagc ttctccagca gcatcacata cggctggtcc
     8761 cacacaccgg cctcgttcca cgcggccagg cgccgccggc aggtcacggt acccgcgagc
     8821 aacccgagag ccacttcgga cctggctcgg gcaacaacgg ctcgaccaac gaccacagtt
     8881 catccgacac gacccagggc cgcggctgac gctttgcccg ccaccagacc aacgagcagt
     8941 cccgccgatc gccgcttgat catcgacttg tgtcagggcc ggttacgccg ccggagaagg
     9001 gcctcagcgg ggcgtgcgct ttgcgggcgg tggtgggcgc gtgcgggagg tcgtcggtga
     9061 tgcggtgaca ggagtcgatg tgggggcact gctgggcggg gcggaccttg caaactgtca
     9121 tgaacgtcag catctgttcc atggcggcag gcagagcttt acggtggcga ttcgtcaggc
     9181 ggcggcgacc agcacccgtg cccggcccgc caggcgcgta cggcttggct cccccaccag
     9241 ccgacgccgg ataccgtggg gtgatcagga cggggtggcc gacggcagcc cgtgcgccct
     9301 ccccgcggcg ccttccccgc ggcgccttcc cctgcactgc acctccacca ggcaccctcg
     9361 gttccgattg tcggcgggga agccgccggc acctgcgacc caggtcgtcc cgataccggg
     9421 gcggacggga gggccggagg gtcgtcgggc aagtcctggc ggcatgtcag gcggcgcggc
     9481 atggcctttc agcgaaggga ggagcactct gctgcggtcc cgccggaagg gttaccggcg
     9541 gtttatcgtg aggctgtgac tgtatgggcc atccataggg tctcaaatgg taagacgaaa
     9601 cacgctgggc aacggtgata catgccacac gatcggcagt gaacgcgcat acaaatcaca
     9661 gaagtccact cggggtgagg tccgcgcccg aaagtcggtc ggcacatgtt ttcggccccg
     9721 ccggacagcg gccgggatga cgtcgagggc tgcggattcg gcgtggcggg tgtgggtggg
     9781 gaatatcgtt tcggccatcg cagacggcgg ggtgccgacg gtccggcgaa cccgaagggg
     9841 tggggggtga ctcctcgtgg acatcgaagc gggcgcataa accgggcatt cagctcgttc
     9901 ttcacggttg gcagcgctgg agccccgctg tatgtttcga ggtgaaacaa actagacgcc
     9961 gttcccaccg gcccgaccag aggtagtcac cttgaaccac atgccgcgtc agcagagctg
    10021 gaagattcag gcggaattac ctgtcgagta cgagataatc gaaagtcatg gccttctcga
    10081 ccccgacaac cccgatctgc tcaggcttcc cggcgggcgc cgggggacgg gcacccgcct
    10141 cgtcgtcctc gaccattccg tcgacgagtt gtacggcgcg gaaatccgca gctacttctc
    10201 gaagaacaaa gtggtggtcg attaccttac gctccccggc tcggaggaga acaaatccat
    10261 cgagcgcgtt ctggaagtgg tcaacaagct caatgaggtc ggcaccaacc gcctcagctc
    10321 cccgcccatt gtcatcggcg gcggtgtcgt cgcggacgtg gtcgggctcg cagcaagcct
    10381 ttaccggcgg ggaatcccct tcgtccgggt gcccaccact ctgctcggtc aggtcgatgt
    10441 cagcgtcgcc gccaagtccg gcatcaacta cgggggatac cgcaaccgcc tcggtgccta
    10501 cacccctcct ccgcggacac tgatcgaccg tcgcttcctc gccaccgtcc cggaccggca
    10561 actgcgcaac ggcatgggcg agatcttcaa gatggccctg atcaaggacc tgcgtctctt
    10621 cgaactcctg gaggagtacg gggcggaact catcgagacg cgcttccagg acccccgggc
    10681 cggaagcacc ggcctgccgg ggacggtggc cgacgaggtc atcggccggg ccatcgcggg
    10741 aatggccgag gaactgcagc ccaacctgtg ggagaaggac ctccagcggt cagtggacta
    10801 cgggcactcc ttctcacccc tggtggagat gcgggccctt cccgagctgt tgcacggcga
    10861 ggccgtggcc atggactgca tcttctccgc cctcatcgcc gccgaccgcg gcttgatcga
    10921 cgatgcccag ctggagcgca tcatcgcggt ggcacggcgc atgggactcg aaccctccca
    10981 tccgctcttc tgcgacgtgg ccctcgtcct ggacggcctc gcggacaccg tgcggcaccg
    11041 cgacggccgg cagaacctgc cgatgctcac cgggatcggc caggtctgct tcctcaacga
    11101 cgtcaccgag aacgagatcg agcgggcctg cgcgggcatg ggcggcctgc tcgacgcgaa
    11161 cgccggccgg ccggggcagc gcatcgggtc cgacctgtga gcgaaggaac cggtgcccgg
    11221 gactcggtgg aggggaaggt cgtggtcgtc accggcggca gctcgggcat aggccgtgcc
    11281 tccgccgccg tattcgccga ggctggcatg cgggtcgtca tcgccgcccg caacgaggag
    11341 cgcggcgcgg aggccgcgca cgagatccga tcgcggggcc acgaggcctg cttcgtccgc
    11401 tgcgacgtca ccagcccgga ccaggtccgg aacctgttcg cacgagtggt ccagcagtac
    11461 ggccgggtgg actgcgcctt caacaacgcc ggtgtgtccg gtgacggacg cctcgcggac
    11521 ctcacgccgc aggacttcga ccgggccttc gcagtcaaca cccgtggcct gtggctctgc
    11581 atgcgcgagg agctgcggtt gatgtccgcc caggaagacg gcggcagcat cgtcaacaac
    11641 acctcggtgc acggcatccg cacgatcttc cccggaatcg gcgcctacgt cgcgtccaag
    11701 cacgccgcgg tggccctgac ccggatggcg gccatggaac atgcgcgcga gggagtccgc
    11761 gtcaacgcgg tcgctcccgg ccccgtcgag tcagagatgc tggctgcgtc ggaggcggcc
    11821 gtcggcggtg cgacgacctg gcgcaggctg atcccgtccg gtgagatcgg cactccgcgc
    11881 caggtcgccg acgtggcgct gtggctgttc tccgccgcct cctcgtacgt caacggacag
    11941 gccgtcggcg tcgacggggg attcctcgcg acctgagccg ctcgcctccc taccccgctt
    12001 cacggagcga aggacacacc catgcaaagc ttcactccct acgacttcat cgtggtcggc
    12061 gcgggcgcgg ccggcagcgt cgtcgccgcc cggctcagcg aggaccccgc acgcagcgtg
    12121 ctgctcctcg aggccgggcc accggacagc gacccgcgca tcgcccggcc cgcctcctgg
    12181 ccgatgctgc tcggcggcga actggactgg ggttaccgga ccgtgccgca gagggcgctc
    12241 cacggcagac ggctcgcctg gccgcgcggc cgggtcgtgg gcggatccgg gtcgatcaac
    12301 gccatggtgc acatccgggg tgccgcctcc gacttcgacg cctggcagca ctggggcggt
    12361 gacacctgga acgcgcagca cctcctgccg tatctggagg gcctggaagg gcccgcccac
    12421 gccgcgccgt acggcagtct ccccgtggcg gagaacaccg atccgcaccc cttcgccgcc
    12481 gcgttcgtcg aggccgcgca gaagtacggg ctgcccggca acccggactt caacgcaggc
    12541 cggcaggagg gtgtgggcct gtaccgcacg acccgcacct ccggcacccc cggcgctccg
    12601 gcccgccgcg gcagtaccgc ccgtacccac ctcgggccgg ccctccaacg cccgaacctc
    12661 accctggtga cggatgccgc agtcctcggt ctcgtcacgg acggcgaccg tgtcaccggt
    12721 gtccgggtcc gccacgacgg cacggtgacc tccgtggcct gcacgacgga ggtcgtggtg
    12781 tgtgccggcg ccgtggcctc gccgcagctt ctgctgctca gcggcctggg tcccgccgcc
    12841 gacctgcggg cgctggacat ccccgtgacc gtggacctgc ccggcgtcgg cgccaacctc
    12901 cacgaccacg tgcaggtctc gctcgcctac gacaccgccg agggccaccc cgtcgccgac
    12961 tcctccaacc tcggcgaggc aggcggcttc gtccgcctgg acagcacggc ggccgagccc
    13021 gaggtgcagc tgtccttcgc gccgatgaag gacctcaacc acgcggaccg gctcggacac
    13081 ggattcacca tcggcccggg cgtcacccgc cccgtcagcc gcggccgcct caccctgggc
    13141 tccgcggacc ccgacgcaca cccgctgatc gaccccgcct atctgacgga cgccgccgac
    13201 atggacgtcc tggcggaggg cgtgcgcatc gcccgcgaca tcgccgccac cgatccgctc
    13261 gcccgtctga ccaccggccg tgccccgctc ggcgcgagag ccacccgccg cgagacggag
    13321 gagttcgtgc gggccaacgc ccagacacag ttccatccgg tcggcacctg ccgtatcggc
    13381 ctcgacgggg actccgacgc ggttgtcgac cccaggctca gggtgcgggg caccagcggg
    13441 ctgcgggtgg ccgacgcctc cgtcatcccc accatgatca ccggaaacat ccacgccgcc
    13501 gtggccgcgg tcgccgaacg cgcggcccga ttcatccagg acgaccatgc atgacacggg
    13561 agtacgcatg acggcacacg acgagcggga cagcaccctg cgctggggtg tcctgggagc
    13621 cacctcctac atcgccaccc acctgatccc ggccatcacc gcgacgcacg gctgcgcact
    13681 gaccgcagtc gccagccgcc ctgaacgggc cgccgccgcg gcggaactcg gccgcgccca
    13741 cggcgccacg gtccacccgg actacagggc gctcatcgcg gaccccgccg tcgacgccgt
    13801 ctacatacca ctgcccaaca cccagcacgt cgactggacc ctgcgggccc tggaggccgg
    13861 taagcacgtc ctggtcgaga agcccatggc gatggacgag gaggactgcg cccggatcga
    13921 gaaggcggcc gaagcggcgt cccgcaccgt gatggaggcg ttcatgtacc gcttccaccc
    13981 ccagcagcgg cgcgccgccg agatcctcgc ttccgggaag atcggcgaac tgcgcggggt
    14041 acgtgcgtcc ttcgcgttcc gtatcgagag cggcagcggc aacatccggc tggacgccgc
    14101 gctgggcggc ggagccacct gggacgtcgg ctgctatgcc gtcgacgtcc cgctgttctt
    14161 cttcggccgg gcccccgggc aggtcagcgc ccacttcagc agccgccccg gcctcgccgt
    14221 ggacaccagc gcggtcgcga cgatggactt cggccagggg cacttcgcag tcgtcgacta
    14281 cagcatcgac tacggcccgc gcgcagccta cgagctccag ggcacgcgcg gcaccctcat
    14341 ggtgcgcaac gcctgggcga tggacggtga ggacggggtc gtcaccgtgc tcaccgagga
    14401 cggcgtccac gaggagaccg tcccgtcggc caaccactac cagctccagg tcgaggcgtt
    14461 cgcggcagcc gtacgcgacg gtgcccccgc tcctgtgccg ctcgccgact cccggcgtac
    14521 ggcacgtgtg ggcagggcgt tcgtggcgtc ggccgccgcc ggcggcgccg ccgtggtcac
    14581 ctctgcgcag gagacggagg gccggtgatt ccgacgaggt caccagcggc ggcccgcacg
    14641 ctgacggtct gcgtcgcctc cgtcgggggg ctgctcttcg gctacggcac cggcgtcatc
    14701 gccggcgccc tgccgctggt gaccgccgaa tatggcctgt cgtcctggtc gcagggcgcc
    14761 gccgtgtcgg ccgccctgct gggagccgca ctgacggctc ccagcagcgg caggctcgcg
    14821 gaccgcttcg gccgtctgcc ggtgatcggc accgcggcgg gggtgtacgc ggtggggagc
    14881 cttgcgtccg cggccgccac cggggccgca tcgctcctcg ccgggcgttt cctggtcggt
    14941 ctgtccctgg gcgccacctc cttcgccgta ccgctgtaca tctcggagat cgcaccgccc
    15001 gcccgccggg gcgcgctggt cacgctcaac cagctcatga tcaccatcgg tctgctgctg
    15061 tcctacgtcg tcgcctacgc cctggaaccg gccggcgcct ggcgttggat gctgggcgtc
    15121 ggcatcgttc cggctctgct cctgctggcc gggacctgcc tggtccacga gtcgccggac
    15181 tggctgcgca gccgcggtca cgacgcacgg gcggcgctgt cggcggcccg actcggtctc
    15241 gggccggtcg acggccccgc tccggtgact gtgcggcggg gtatcggcct gcgcccggcc
    15301 tgcgcgctgg cgggccgccg gtgggtggcg ctgggtcttg cgatcgcggt cctggtccac
    15361 ctgaccggcc tgaacacggc tgtctactac gcccccacga tcctggcctc aggcggtctg
    15421 accccggccg gagggatcgt cggatcgatc ctggtgggcc tgtgcaacgt catggccacg
    15481 gtgatcaccg tgctgttcct cgaccgctgg gggcgacgcc cgctgatgat cggcggactc
    15541 gttgtcatgg cgttcaccgc tgtggcgatc gccgcggccg aactctccgg cgaccgaggg
    15601 gccgtcgccg ccctgttgct gtgcctcttc atcacggccg gtgccgtcgg accggcggcg
    15661 gtgttctggg tgtacatcgc ggagatctac ccttcccagg cccgaggagc gctgatgagc
    15721 ctggcgacag cggcgcactg ggcggcggat ttcgtggtgg ccacgacgtt cctcccgctg
    15781 gtccagcacc tgtcactggc cgggacgttc gcactgtacg ccgggatcac cggggcgtcg
    15841 gcgctggcac tggcccggta catgcccgag acgcggggta ggccactggt ggccgccgcg
    15901 cagccggcat ccgtccgcgt cgcggagtga cgcggacggt gaccacagcc cgaccgcgca
    15961 ccacagccca ggtgcgaagg tccgaccgtt cgcacggact gcggcccggg ctccccctct
    16021 ggcgaacacg acccgctccg gaaccggaaa ggcacacatg caccccgatc tctccccccg
    16081 ccacgccagt tgtctgctct tcgactggga cggcaccctg gtcgacagcc agtacgccaa
    16141 ctaccgggcg atggcggccg ttctgtccag cgagggcgtg gacctggagc aggcgtggtt
    16201 cgacgcgcgc acgggactgt cgtcggcgga gatgatccgc accctggtcg acgagcgctc
    16261 cctgcggctc tcgcgccctg tggaagatct cgtcgccgac cgcgaccgga tgttcctgga
    16321 agaggcccac accgtacggc cgcaccagga agtgctccag gtcgtcgagg ccatgcgcgg
    16381 ccgggtcccc atggcggtgg cgtccggcgg agcgcgccac gtcatcgagg cgaccctgcg
    16441 ccaccagccg ttccacagcc acttcgacgc cctcgtcacc cgtgacgacg tcgaccgtgg
    16501 aaagcccgcc cccgacatct tcctgcacgc ggcggaactg ctcggggccc acccctcgcg
    16561 ctgcaccgtc tacgaggaca gcgacgaggg cgtcgaggca gcccacgcgg cgggtatgac
    16621 cgtcatcgac gtgcgcccct acacccgcct ccgcttccgt tccggcacct gaagccgatt
    16681 gccgccccgg cggttgacgg agagggcgtc ccgggccgtt cgctgccgag tcccgacggc
    16741 ctgctgcacg gagtgagcag cgggcggcgg gccgaggcgg caaccggccc gcgccgagga
    16801 ggtcgattcc tcagcaagat gatttgtgcg ccctcaacag ggaacgttga tgctgtaggt
    16861 gcgctggccc gagtcgaggg cctggtcgct cccccagtac ggcccgacct ggtggtatgt
    16921 catggtgacg ctgtaggtgc cgcagacggt cgtcgacagg gccgcgcttg ctgaaccggc
    16981 ggcggaggtc tgccggccac tgacgccgta gctgtggctg gtgccgccga cgccggccgc
    17041 gcccttggcg tcccaggacg ccggggaacc gctgctcgcg tagtaccagg cgctgcccca
    17101 gtagtactgg acctgtcgcg tgttgacgac gacggagacc gctccgctgg aatcggcctg
    17161 caagcacagc tgaacctcgg cgtaggtcca ctgaccgttg ccgtagaagc tttcggtcgg
    17221 accgcagtag gtgccggccg gggcagcggc gcgctcttgg gcggctgccg gtgcggccag
    17281 ggacgcaccg gccagggcga tggccgcagc accgaccccg atggctgcgg atcgtctgcc
    17341 ggcgggggtg gtggtgcgtc cggtgagtcg catggtcggc cctcctgttt ccgcgtgacg
    17401 cccctggtca gcggggcatg accaggacag cagtcccctg tctggccggg tggtgttatg
    17461 tacgcggttc actcggtcgg gtagggctga gacatcgacc tcgcggccgc tatcacccgc
    17521 atgggcaaca gtcggaccgt agccagcaac gacgcccgcc cgatggcggt atgccgccgc
    17581 gcgccttcac gccgccggaa cgcctgttct agcccggtga gcgtggccaa tggttcaggc
    17641 tgcggtggat gcgtgggtgt tcccggtcgg tgtcgatcca ggggtgtagc cggggccagg
    17701 cggtgatcag cgcttcgtgg gcgaggctga cgacgtcgtg gccaagggtg agcagacgtg
    17761 cgcggaccag gtgttcacga cgacggccgt ggcgacggcg ccaccggtgc ggggctcggc
    17821 cgccgcctct gcggccgcct catcgactac gactgcaatg tggcaggcgg ggccggtggg
    17881 ccctggatct ccaggacgac cgcggttcca gcgacagtcc ggtcctcgtg catggtgatc
    17941 acttggccgg tctgaagctg ctgccacttc gacggggaga gcggtgccag acgcaccgtg
    18001 gcctgccctc cgggctccat gaaaggcgtg aactccaccc aaagggcggc gatgtggagg
    18061 tcgggttcgg ctgtcgggag ttttcctccg gtgttccaca tcggtcgtag gacaccggct
    18121 ccggagaaag gtgtctgccg gcgggcctcg tcagctggtc tgagggtgag gtcggctcga
    18181 atgatgccgt tgcgggtctc gaagcaccgc cagtgacacc aggccgcgct cctgtcgagt
    18241 cgcaactgct cggcggcggt ggcgagggtc tgccagaagg cgagcggaag cgggtggaca
    18301 tcaccaagct cctccaacag gtcgagagcg acttcccact cgtcgtggac gaggtactcc
    18361 cagacgtcgt tcaccgtgat gtcgttctcg gtggcgacgg cttcggggac cagcagtgag
    18421 gcggcttcca gcagcttggg aacgtccatg cctggattct gggtgtccag ggcgatcagc
    18481 aggtgggact tgccggtgcc ggtgtcgccg atcaggcaga gaggctgtcc cttcttgatc
    18541 cctcgcagct cgggagggtg ggttcttcac ggtcacgccc accaagccga cagatcggac
    18601 cgtccggtcc ggtcgcgccc cgggcgaacc gcctgagcct gggggcgaca ccgctctgct
    18661 cctcgcggtc cctatgatct tcgacctcat cgaggaaggg ctcgtatggc ctttggagaa
    18721 catgtggaac gggtcgccgc cgaggtcgtc ggagagttcc cggcggacag cgggatctac
    18781 gcggtgacgt tccgcatcga cagcgtcgac caggatccgc ggcttccgta cctggcgatc
    18841 ggctacacga ccgaggccga cgctacggcg gcggcgcagc agacgccgga tgcctgggag
    18901 gcacgctgga gttatgcgtt cttccccgag acgggactcg aaggggtgag gaccgtcgga
    18961 cgtgaccctg acggcgcgcg gtcgcaccgg cgggaggccg aggcccgggg gctctggtac
    19021 gaggacgacg acgaggcgga cggccgcgac gaacggctgg tcgagtggtt ctacgaggtg
    19081 tgcgtcgcgg cggccaggcg cctccacgac agcggccgga tcgtggcggt gctggggcgg
    19141 ccggtgccgg tgatcctcta cgacatgttc gacccggacg cgatgttcga gctgacgtcg
    19201 agcgccaatc cggcggacct ggtcgccgac ttcatggcgg aggcaccctg acgcccggtc
    19261 accgtccgcg ccctgacatc cggtcaccgc cggtccgcac ccctcgcgtg tgacagcggc
    19321 gtacggaaca cgtcacagag ctcgtaccgt cggccaccgt ggcttccccg gagctccgcc
    19381 gggtgggatg tttacccgcc ggagcggccc gcggcgggcc gcggacagcc atcgggggga
    19441 caccttgacg cacctgcacc acggaaacgg cagcggcggt agtgccggag gggcacgaag
    19501 aaccgtcagg acgggcggag ccggtacgac gcggcgtcgc cgggcggccg tgaccgccac
    19561 cgcgctcgcc atgactgtgc ccttgacgct caacgcagca ggagacgcgg gagcggcggc
    19621 ggaccacccc atcgtcttcg cacgctacac cgcgggagct cccgtcgagg acctctacgc
    19681 catctcggcc ggcggcggca cgccggtcaa actcacccac acctccaccg tcagcgacgt
    19741 gatgcccagt tggtccccgg acggcaagcg ggtggccttc gtgcgctatg gatccggcgg
    19801 cgcaatcgac ggcgtctgga cgatgaagac cacgggcggc gacctgaagg ccgtgcccgg
    19861 caccaagggc gcatccgacc cggcgtggtc cccggacggc aagcggatcg cctatgccaa
    19921 gccggtcggc acccagcgcg agatctacgt ggccgacatc gacggcactc ccgccacccg
    19981 gctcacccac accgcggcgg acgacctcca tccgacgtgg tccccggacg gcaagtacct
    20041 cgccttcaac cgggcggacg ccggcggaca cagcagggtc atgcggattc ggctgtccac
    20101 cctggcccag acggcggtca ccggttccgg ctcccacgac tggacgccgg actggtcaca
    20161 cggcaaccgc atcgtcttca gccgggtcga ctcctcgggc ttcgcacatc tctacctcgt
    20221 ccgccccgac ggcaccggag tgcaccgcat cacctcgtcc cgcttcaacg acaagtaccc
    20281 ctcgtggtcc ccggacggca gccgtctggt cttcacccga ggcgggaccg acgacgcgga
    20341 ccccgaacac ctgtacctgg tccgcgcgga cggcaccgga acgaccaagc tcaccaagac
    20401 cgactcccac gacatggagg cggactggcg cccctgacgt actcctttcc gagggaggcg
    20461 actgcgggcc cggttcgcag cggcgggccg ggccccggtg gctcaggcat cgttcaccca
    20521 gtgcccctcg cttcggcagc ttccgcgcgg gcctgggcgc ggccgtacac gtcggcggcc
    20581 tgagcgtagg tttgcccggc tgcgacgagg ttcccggtgt cgtggtgagc acgcgcgaga
    20641 tggtgcaggg tacgtccggt ctcgtaccag tcgtcgccct gcgatggcgc tccaggggca
    20701 gtgccgatcg cctcgatggt ctcctctccc cgcatgtccc gcaggacgac ggcgaggctg
    20761 tgccacttcg tggcgtctcc cgcgcggttg gcggtacccc ggaggcgctc cggggcctgc
    20821 ctgatgcatc ggcacctcgg accggcgctc ggcacgcacg aggacggcac cgaggtcgat
    20881 ccacaccgag gcctcgctca cgcggtcacc gagttcatgg atgaggtcgc gggcaggggt
    20941 gtgggcttcg attggctgct ccgcgtccct cacgtccccc ggggcgaggc cgagaccgtt
    21001 gccgaggtcg tgcatggcct cggcctcgct ctggcgatcg ctgatgtccc gaaccagcgc
    21061 gtgtgcctcg gcacgggcgt cgatggcctc cgtctcctgc cccaggtacg acagcgcgcg
    21121 accgaggttg gtgcacgcca cggcctcgct ccagcggtcg cgcctgcggt gcgccaccag
    21181 gccgacggca ccagcgcgtg
//
