GCF_017084465.1 - 10 region(s)

Identified secondary metabolite regions using strictness 'relaxed'

NZ_CP070896.1 (Lacrimispora xylanisolvens)

Region	Type	From	To
Region 1	cyclic-lactone-autoinducer	29,729	50,199
Region 2	cyclic-lactone-autoinducer	380,997	401,646
Region 3	deazapurine,t3nrps-iterative	896,925	941,418
Region 4	cyclic-lactone-autoinducer	1,302,362	1,322,907
Region 5	cyclic-lactone-autoinducer,lanthipeptide-class-i	1,643,566	1,683,460
Region 6	ranthipeptide	2,048,110	2,069,779
Region 7	RRE-containing	3,821,496	3,843,043
Region 8	RRE-containing	3,911,482	3,931,772
Region 9	terpene-precursor	4,052,654	4,073,541
Region 10	NRPS,NRPS-like	4,934,863	4,982,501

NZ_CP070896.1 - Region 1 - cyclic-lactone-autoinducer

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Location: 29,729 - 50,199 nt. (total: 20,471 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

JWH23_RS00230: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000540.5	0.37	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0002449.2	0.36	other (other)	sarasinoside	uncultured bacterium
BGC0002667.2	0.33	ribosomal	estericin A	Clostridium estertheticum
BGC0002579.2	0.31	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002510.2	0.31	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000619.3	0.27	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001388.3	0.27	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001602.3	0.27	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0002547.2	0.25	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis
BGC0000624.3	0.24	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000540.5	0.37	ribosomal	paenibacillin	Paenibacillus polymyxa OSY-DF
BGC0002449.2	0.36	other (other)	sarasinoside	uncultured bacterium
BGC0002667.2	0.33	ribosomal	estericin A	Clostridium estertheticum
BGC0002579.2	0.31	ribosomal	carnobacteriocin XY	Carnobacterium maltaromaticum
BGC0002510.2	0.31	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces sp.
BGC0000619.3	0.27	ribosomal	gassericin T	Lactobacillus gasseri
BGC0001388.3	0.27	ribosomal	gassericin E	Lactobacillus gasseri
BGC0001602.3	0.27	ribosomal	gassericin-T	Lactobacillus gasseri
BGC0002547.2	0.25	PKS	youssoufene A1, youssoufene B1, youssoufene B2, youssoufene B3, youssoufene B4	Streptomyces youssoufiensis
BGC0000624.3	0.24	ribosomal	salivaricin CRL1328 α peptide, salivaricin CRL1328 β peptide	Lactobacillus salivarius

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 20.65 out of 23.79

Confidence: strong

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.21 out of 27.78

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 23.05 out of 23.05

Confidence: strong

Additional weak hits (3):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 21.55 out of 30.22

Confidence: weak

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 20.11 out of 25.88

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 21.89 out of 29.65

Confidence: weak

TFBS Finder

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
IolR	Regulator of the inositol catabolism

NZ_CP070896.1 - Region 2 - cyclic-lactone-autoinducer

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Location: 380,997 - 401,646 nt. (total: 20,650 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

JWH23_RS02115: polyprenol-monophosphomannose synthase ppm1

smcogs: SMCOG1123: polyprenol-monophosphomannose synthase ppm1

JWH23_RS02200: cysteine synthase

smcogs: SMCOG1081: cysteine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001864.3	0.45	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001863.4	0.43	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000412.5	0.42	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000571.3	0.41	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002698.2	0.46	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0001864.3	0.45	ribosomal	listeriocytocin	Listeria monocytogenes SLCC2540
BGC0001862.4	0.44	ribosomal	pallidocin	Aeribacillus pallidus
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0001863.4	0.43	ribosomal, terpene	bacillicn CER074	Bacillus mycoides
BGC0000412.5	0.42	NRPS	pyochelin	Pseudomonas aeruginosa PAO1
BGC0000551.5	0.42	ribosomal	SapB	Streptomyces coelicolor A3(2)
BGC0001229.4	0.42	ribosomal	SBI-06990 A1, SBI-06989 A2	Streptomyces bingchenggensis BCW-1
BGC0000513.3	0.42	ribosomal	Ery-9, Ery-6, Ery-8, Ery-7, Ery-5, Ery-4, Ery-3	Saccharopolyspora erythraea NRRL 2338
BGC0000571.3	0.41	ribosomal	burhizin	Paraburkholderia rhizoxinica HKI 454

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.57 out of 27.55

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.28 out of 26.06

Confidence: medium

SypG

Description: Regulator of biofilm formation and host colonization
Species: Vibrio fischeri ES114
Score: 24.91 out of 29.25

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.50 out of 27.78

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
GnfM	Regulator of nitrogen-fixation genes
MogR	Repressor of flagellar motility genes
SypG	Regulator of biofilm formation and host colonization

NZ_CP070896.1 - Region 3 - deazapurine,t3nrps-iterative

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Location: 896,925 - 941,418 nt. (total: 44,494 nt) Show pHMM detection rules used

deazapurine: (GTP_cyclohydroI and PTPS and QueE and QueC and not (dpdA1 or bTGT))
t3nrps-iterative: (AMP-binding and PP-binding and (DUF98 or Orn_Arg_deC_N or Orn_DAP_Arg_deC) and not ATP-grasp)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: oxidase oxidoreductase

JWH23_RS05115: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

JWH23_RS05215: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: aminotransferase

JWH23_RS05200: aminotransferase

smcogs: SMCOG1019: aminotransferase

Lyases: decarboxylase

JWH23_RS05165: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

JWH23_RS05170: diaminopimelate decarboxylase

smcogs: SMCOG1264: diaminopimelate decarboxylase

Ligases: ligase

JWH23_RS05160: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000881.3	0.34	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5	0.34	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0001937.4	0.28	other (other)	tubercidin	Streptomyces tubercidicus
BGC0000879.5	0.27	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus
BGC0001166.5	0.26	NRPS	HC-toxin	Alternaria jesenskae
BGC0001250.4	0.26	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.26	NRPS	epichloenin A	Epichloe festucae
BGC0001641.4	0.25	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0000310.5	0.25	NRPS	bacitracin	Bacillus licheniformis
BGC0002164.2	0.24	NRPS	peramine	Epichloe festucae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001166.5	0.59	NRPS	HC-toxin	Alternaria jesenskae
BGC0001250.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001251.4	0.59	NRPS	epichloenin A	Epichloe festucae
BGC0001641.4	0.58	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002164.2	0.58	NRPS	peramine	Epichloe festucae
BGC0001268.4	0.54	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000881.3	0.49	other (other)	toyocamycin	Streptomyces ahygroscopicus subsp. wuzhouensis
BGC0001808.5	0.49	other (other)	toyocamycin	Streptomyces diastatochromogenes
BGC0001937.4	0.46	other (other)	tubercidin	Streptomyces tubercidicus
BGC0000879.5	0.45	other (other)	toyocamycin, sangivamycin	Streptomyces rimosus

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

No hits above weak threshold.

Weak hits (1):

ClgR

Description: Caseinolytic protease gene regulator
Species: Corynebacterium glutamicum ATCC 13032
Score: 22.14 out of 30.22

Confidence: weak

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

TFBS Finder

NRPS/PKS substrate predictions

JWH23_RS05160: X

AMP-binding (7..412): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: FYFAFDVSVKDSIWLFSGEVNLYGPTEITCNCTY
Nearest Stachelhaus code(s):: Ser DVWHLSLVDK (53% 8Å match)
Stachelhaus code match:: 60% (weak)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description

NZ_CP070896.1 - Region 4 - cyclic-lactone-autoinducer

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Location: 1,302,362 - 1,322,907 nt. (total: 20,546 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: acetyltransferase

JWH23_RS07420: acetyl-CoA acetyltransferase

smcogs: SMCOG1124: acetyl-CoA acetyltransferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.38	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.36	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001098.5	0.30	NRPS, PKS	iturin	Bacillus subtilis
BGC0001090.5	0.30	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0002284.3	0.25	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002467.2	0.23	NRPS	thermochelin	Thermocrispum agreste DSM 44070
BGC0002300.2	0.19	NRPS	albomycin delta2, albomycin delta1, albomycin epsilon	Streptomyces sp. ATCC 700974

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000866.5	0.38	other (other)	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867.3	0.36	other (other)	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001098.5	0.30	NRPS, PKS	iturin	Bacillus subtilis
BGC0001090.5	0.30	NRPS, PKS	bacillomycin D	Bacillus velezensis FZB42
BGC0002284.3	0.25	other (other)	corynecin III, corynecin I, corynecin II	Rhodococcus sp. H-CA8f
BGC0002467.2	0.23	NRPS	thermochelin	Thermocrispum agreste DSM 44070
BGC0002300.2	0.19	NRPS	albomycin delta2, albomycin delta1, albomycin epsilon	Streptomyces sp. ATCC 700974

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.13 out of 26.06

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 22.67 out of 26.06

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 23.11 out of 27.78

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.70 out of 26.06

Confidence: medium

TFBS Finder

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
MogR	Repressor of flagellar motility genes

NZ_CP070896.1 - Region 5 - cyclic-lactone-autoinducer,lanthipeptide-class-i

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Location: 1,643,566 - 1,683,460 nt. (total: 39,895 nt) Show pHMM detection rules used

cyclic-lactone-autoinducer: (TIGR04223 or AgrB)
lanthipeptide-class-i: (((Lant_dehydr_N or Lant_dehydr_C) and cds(LANC_like and not Pkinase)) and not (YcaO or TIGR03604))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Lanthipeptides

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase dehydratase

JWH23_RS09285: Lanthionine synthetase C family protein

smcogs: SMCOG1140: Lanthionine synthetase C family protein

JWH23_RS09295: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

JWH23_RS09305: Lantibiotic dehydratase domain protein

smcogs: SMCOG1155: Lantibiotic dehydratase domain protein

Translocases: transporter

JWH23_RS09170: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

JWH23_RS09175: sugar-binding lipoprotein

smcogs: SMCOG1143: sugar-binding lipoprotein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.44	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0000506.4	0.37	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.35	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0000556.5	0.35	ribosomal	streptin	Streptococcus pyogenes
BGC0000537.3	0.34	ribosomal	nisin U	Streptococcus uberis
BGC0000535.4	0.34	ribosomal	nisin A	Lactococcus lactis subsp. lactis
BGC0000515.4	0.33	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0002323.2	0.32	ribosomal	nisin J	Staphylococcus capitis
BGC0000536.3	0.32	ribosomal	nisin Q	Lactococcus lactis
BGC0000541.5	0.31	ribosomal	paenicidin A	Paenibacillus polymyxa

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002576.2	0.75	ribosomal	mechercharmycin	Thermoactinomyces sp.
BGC0001289.5	0.59	ribosomal	penisin	Paenibacillus ehimensis
BGC0000538.3	0.56	ribosomal	nisin Z	Lactococcus lactis
BGC0000556.5	0.54	ribosomal	streptin	Streptococcus pyogenes
BGC0000515.4	0.54	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2
BGC0000506.4	0.53	ribosomal	entianin	Bacillus subtilis subsp. spizizenii
BGC0000559.4	0.52	ribosomal	subtilin	Bacillus subtilis subsp. spizizenii ATCC 6633
BGC0002668.2	0.52	ribosomal	cesin A	Clostridium estertheticum
BGC0002323.2	0.51	ribosomal	nisin J	Staphylococcus capitis
BGC0000541.5	0.51	ribosomal	paenicidin A	Paenibacillus polymyxa

Similar known clusters from MIBiG 4.0

Similar subclusters

No significant matches found.

Lanthipeptide predictions

Lanthipeptide(s) for JWH23_RS09295

JWH23_RS09310

Leader:

MNKDFDLDLKMDKGSVDVGESK

Core:

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

Core with dehydrations:

IADhaVAYCysDhbPGCysLDhbGDhbDhbCysGDhbDhaECysGMDhbRNCysDhbNDhbWLCysY

antiSMASH-DB 4.0 matches for JWH23_RS09310

100.0%

NZ_CP070896.1and 2 others:

NZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptideNZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptide

Lanthipeptides: JWH23_RS09310_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

35

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

35

85.7%

NZ_QLLI01000019.1:

Lanthipeptides: DET54_RS28075_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGC TG+TCGTSECG+TRNCTNTWLC

1

ITSVAYCTPGCNTGSTCGTSECGLTRNCTNTWLC

34

80.0%

NZ_CP029639.1:

Lanthipeptides: DMB88_RS07755_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGC TG+TCG+SECG+TR CTNTWLC

1

ITSVAYCTPGCNTGSTCGSSECGLTRQCTNTWLC

34

with 86 more sequence matches

Only the first 10 are displayed here.

80.0%

NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGCLTG CG+SECG+TR+CTNTWLC

1

ITSVAYCTPGCLTGELCGSSECGLTRSCTNTWLC

34

65.7%

NZ_CABIWO010000014.1:

Lanthipeptides: FY209_RS17155_lanthipeptide

3

SVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

SVAYCTPGC+TG CG+SECG+TRNCT + C

2

SVAYCTPGCVTGQLCGSSECGLTRNCTGSIAC

33

45.7%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

1

IASVAYCTPGCLTGTT-CGTSECGMTRNCTNT

31

I S + CTPGC TG C T C T CT T

1

ITSKSLCTPGCPTGALGCFTQNCDPTNGCTIT

32

42.9%

NZ_CP073683.1and 1 other:

NZ_CP092779.1 Lanthipeptides: MJ749_RS08075_lanthipeptide

Lanthipeptides: KAI37_RS08180_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECG

23

+ SV CTPGC+TG CG+SECG

1

VTSVFACTPGCITGPNCGSSECG

23

40.0%

NZ_CP025696.1and 1 other:

NZ_LNZF01000001.1 Lanthipeptides: AVK83_RS25720_lanthipeptide

Lanthipeptides: C0638_RS24580_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECG

23

+ S CT GCLTG+ CG+SECG

1

VTSWFACTGGCLTGSNCGSSECG

23

40.0%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

1

IASVAYCTPGCLTGTTCG----TSECG

23

I SV+ CTPGC TG G T+ CG

1

ITSVSLCTPGCKTGALMGCNMKTASCG

27

37.1%

NZ_AULX01000006.1:

Lanthipeptides: H583_RS0100280_lanthipeptide

1

IASVAYCTPGCLTGT-TCGTSECGMTRNCTN

30

I S + CTPGC+TG C T C ++ +C

1

ITSKSLCTPGCITGVLMCFTKGCEISHSCIK

31

37.1%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCT

29

I S + CTPGC+TG G + +T NC+

1

ITSKSLCTPGCVTGVLMGCALKTITCNCS

29

37.1%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

1

IASVAYCTPGCLTGTTCG----TSECG

23

I S + CTPGC TG G T+ CG

1

ITSYSLCTPGCKTGALMGCTMKTASCG

27

37.1%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCT

29

I S + CTPGC+TG G + T NC+

3

ITSKSLCTPGCVTGLLMGCAGSSATCNCS

31

MIBiG 4.0 matches for JWH23_RS09310

28.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

IASVAYCTPGCLTGTTCG

18

I S++ CTPGC TG G

1

ITSISLCTPGCKTGALMG

18

Lanthipeptide(s) for JWH23_RS09300

JWH23_RS09310

Leader:

MNKDFDLDLKMDKGSVDVGESK

Core:

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

Core with dehydrations:

IADhaVAYCysDhbPGCysLDhbGDhbDhbCysGDhbDhaECysGMDhbRNCysDhbNDhbWLCysY

antiSMASH-DB 4.0 matches for JWH23_RS09310

100.0%

NZ_CP070896.1and 2 others:

NZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptideNZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptide

Lanthipeptides: JWH23_RS09310_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

35

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

35

85.7%

NZ_QLLI01000019.1:

Lanthipeptides: DET54_RS28075_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGC TG+TCGTSECG+TRNCTNTWLC

1

ITSVAYCTPGCNTGSTCGTSECGLTRNCTNTWLC

34

80.0%

NZ_CP029639.1:

Lanthipeptides: DMB88_RS07755_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGC TG+TCG+SECG+TR CTNTWLC

1

ITSVAYCTPGCNTGSTCGSSECGLTRQCTNTWLC

34

with 86 more sequence matches

Only the first 10 are displayed here.

80.0%

NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGCLTG CG+SECG+TR+CTNTWLC

1

ITSVAYCTPGCLTGELCGSSECGLTRSCTNTWLC

34

65.7%

NZ_CABIWO010000014.1:

Lanthipeptides: FY209_RS17155_lanthipeptide

3

SVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

SVAYCTPGC+TG CG+SECG+TRNCT + C

2

SVAYCTPGCVTGQLCGSSECGLTRNCTGSIAC

33

45.7%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

1

IASVAYCTPGCLTGTT-CGTSECGMTRNCTNT

31

I S + CTPGC TG C T C T CT T

1

ITSKSLCTPGCPTGALGCFTQNCDPTNGCTIT

32

42.9%

NZ_CP073683.1and 1 other:

NZ_CP092779.1 Lanthipeptides: MJ749_RS08075_lanthipeptide

Lanthipeptides: KAI37_RS08180_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECG

23

+ SV CTPGC+TG CG+SECG

1

VTSVFACTPGCITGPNCGSSECG

23

40.0%

NZ_CP025696.1and 1 other:

NZ_LNZF01000001.1 Lanthipeptides: AVK83_RS25720_lanthipeptide

Lanthipeptides: C0638_RS24580_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECG

23

+ S CT GCLTG+ CG+SECG

1

VTSWFACTGGCLTGSNCGSSECG

23

40.0%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

1

IASVAYCTPGCLTGTTCG----TSECG

23

I SV+ CTPGC TG G T+ CG

1

ITSVSLCTPGCKTGALMGCNMKTASCG

27

37.1%

NZ_AULX01000006.1:

Lanthipeptides: H583_RS0100280_lanthipeptide

1

IASVAYCTPGCLTGT-TCGTSECGMTRNCTN

30

I S + CTPGC+TG C T C ++ +C

1

ITSKSLCTPGCITGVLMCFTKGCEISHSCIK

31

37.1%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCT

29

I S + CTPGC+TG G + +T NC+

1

ITSKSLCTPGCVTGVLMGCALKTITCNCS

29

37.1%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

1

IASVAYCTPGCLTGTTCG----TSECG

23

I S + CTPGC TG G T+ CG

1

ITSYSLCTPGCKTGALMGCTMKTASCG

27

37.1%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCT

29

I S + CTPGC+TG G + T NC+

3

ITSKSLCTPGCVTGLLMGCAGSSATCNCS

31

MIBiG 4.0 matches for JWH23_RS09310

28.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

IASVAYCTPGCLTGTTCG

18

I S++ CTPGC TG G

1

ITSISLCTPGCKTGALMG

18

Lanthipeptide(s) for JWH23_RS09305

JWH23_RS09310

Leader:

MNKDFDLDLKMDKGSVDVGESK

Core:

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

Core with dehydrations:

IADhaVAYCysDhbPGCysLDhbGDhbDhbCysGDhbDhaECysGMDhbRNCysDhbNDhbWLCysY

antiSMASH-DB 4.0 matches for JWH23_RS09310

100.0%

NZ_CP070896.1and 2 others:

NZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptideNZ_CP070896.1 Lanthipeptides: JWH23_RS09310_lanthipeptide

Lanthipeptides: JWH23_RS09310_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

35

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY

35

85.7%

NZ_QLLI01000019.1:

Lanthipeptides: DET54_RS28075_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGC TG+TCGTSECG+TRNCTNTWLC

1

ITSVAYCTPGCNTGSTCGTSECGLTRNCTNTWLC

34

80.0%

NZ_CP029639.1:

Lanthipeptides: DMB88_RS07755_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGC TG+TCG+SECG+TR CTNTWLC

1

ITSVAYCTPGCNTGSTCGSSECGLTRQCTNTWLC

34

with 86 more sequence matches

Only the first 10 are displayed here.

80.0%

NZ_CP075910.1and 3 others:

NZ_CP075971.1 Lanthipeptides: KLF29_RS14850_lanthipeptideNZ_CP075982.1 Lanthipeptides: KLF51_RS14900_lanthipeptideNZ_CP075994.1 Lanthipeptides: KLF26_RS16110_lanthipeptide

Lanthipeptides: KLF45_RS14835_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

I SVAYCTPGCLTG CG+SECG+TR+CTNTWLC

1

ITSVAYCTPGCLTGELCGSSECGLTRSCTNTWLC

34

65.7%

NZ_CABIWO010000014.1:

Lanthipeptides: FY209_RS17155_lanthipeptide

3

SVAYCTPGCLTGTTCGTSECGMTRNCTNTWLC

34

SVAYCTPGC+TG CG+SECG+TRNCT + C

2

SVAYCTPGCVTGQLCGSSECGLTRNCTGSIAC

33

45.7%

NZ_CP085954.1:

Lanthipeptides: LK411_RS13585_lanthipeptide

1

IASVAYCTPGCLTGTT-CGTSECGMTRNCTNT

31

I S + CTPGC TG C T C T CT T

1

ITSKSLCTPGCPTGALGCFTQNCDPTNGCTIT

32

42.9%

NZ_CP073683.1and 1 other:

NZ_CP092779.1 Lanthipeptides: MJ749_RS08075_lanthipeptide

Lanthipeptides: KAI37_RS08180_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECG

23

+ SV CTPGC+TG CG+SECG

1

VTSVFACTPGCITGPNCGSSECG

23

40.0%

NZ_CP025696.1and 1 other:

NZ_LNZF01000001.1 Lanthipeptides: AVK83_RS25720_lanthipeptide

Lanthipeptides: C0638_RS24580_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECG

23

+ S CT GCLTG+ CG+SECG

1

VTSWFACTGGCLTGSNCGSSECG

23

40.0%

NZ_FBTD01000003.1:

Lanthipeptides: PB1E_RS03075_lanthipeptide

1

IASVAYCTPGCLTGTTCG----TSECG

23

I SV+ CTPGC TG G T+ CG

1

ITSVSLCTPGCKTGALMGCNMKTASCG

27

37.1%

NZ_AULX01000006.1:

Lanthipeptides: H583_RS0100280_lanthipeptide

1

IASVAYCTPGCLTGT-TCGTSECGMTRNCTN

30

I S + CTPGC+TG C T C ++ +C

1

ITSKSLCTPGCITGVLMCFTKGCEISHSCIK

31

37.1%

NZ_CP013655.1and 2 others:

NZ_CP013655.1 Lanthipeptides: ATZ35_RS03635_lanthipeptideNZ_CP013655.1 Lanthipeptides: ATZ35_RS03630_lanthipeptide

Lanthipeptides: ATZ35_RS03640_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCT

29

I S + CTPGC+TG G + +T NC+

1

ITSKSLCTPGCVTGVLMGCALKTITCNCS

29

37.1%

NZ_CP090412.1and 3 others:

NZ_QSTB01000004.1 Lanthipeptides: DXC22_RS03785_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptideNZ_VSTZ01000009.1 Lanthipeptides: FYK98_RS07445_lanthipeptide

Lanthipeptides: LZF92_RS09890_lanthipeptide

1

IASVAYCTPGCLTGTTCG----TSECG

23

I S + CTPGC TG G T+ CG

1

ITSYSLCTPGCKTGALMGCTMKTASCG

27

37.1%

NZ_FNDP01000013.1and 1 other:

NZ_FNDP01000013.1 Lanthipeptides: BLP54_RS11225_lanthipeptide

Lanthipeptides: BLP54_RS11220_lanthipeptide

1

IASVAYCTPGCLTGTTCGTSECGMTRNCT

29

I S + CTPGC+TG G + T NC+

3

ITSKSLCTPGCVTGLLMGCAGSSATCNCS

31

MIBiG 4.0 matches for JWH23_RS09310

28.6%

BGC0000535.4 (ADJ56352.1):

Lanthipeptide: nisin A

1

IASVAYCTPGCLTGTTCG

18

I S++ CTPGC TG G

1

ITSISLCTPGCKTGALMG

18

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Transcription Factor Binding Sites

Binding sites found:

RpoN

Description: Regulator of nitrogen assimilation and virulence
Species: Salmonella & Vibrio sp.
Score: 16.07 out of 18.46

Confidence: medium

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 24.21 out of 26.06

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.23 out of 26.06

Confidence: medium

AfsR

Description: Pleiotropic regulatory for antibiotic production
Species: Streptomyces coelicolor
Score: 19.28 out of 23.05

Confidence: medium

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.63 out of 23.79

Confidence: medium

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 21.05 out of 26.85

Confidence: medium

Additional weak hits (6):

RutR

Description: Regulator of the pyrimidine and purine metabolism
Species: Escherichia coli str. K-12 substr. MG1655
Score: 20.41 out of 26.85

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 25.30 out of 31.73

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.85 out of 39.62

Confidence: weak

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 23.46 out of 28.14

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.87 out of 33.14

Confidence: weak

LexA variant 1

Description: Repressor of DNA damage response
Species: Streptomyces coelicolor
Score: 20.87 out of 29.65

Confidence: weak

Lanthipeptides

RREFinder

TFBS Finder

Core peptide predictions

JWH23_RS09310 - Class I

Cleavage pHMM score: -2.00

RODEO score: 30

Monoisotopic mass: 3500.5 Da

Molecular weight: 3503.0 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 3521.0 Da N = 1; 3539.0 Da N = 2; 3557.1 Da N = 3; 3575.1 Da N = 4

JWH23_RS09310 - Class I

Cleavage pHMM score: -2.00

RODEO score: 30

Monoisotopic mass: 3500.5 Da

Molecular weight: 3503.0 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 3521.0 Da N = 1; 3539.0 Da N = 2; 3557.1 Da N = 3; 3575.1 Da N = 4

JWH23_RS09310 - Class I

Cleavage pHMM score: -2.00

RODEO score: 30

Monoisotopic mass: 3500.5 Da

Molecular weight: 3503.0 Da

Number of bridges: 6

Alternative weights: (assuming N unmodified Ser/Thr residues); 3521.0 Da N = 1; 3539.0 Da N = 2; 3557.1 Da N = 3; 3575.1 Da N = 4

RRE predictions

: RRE type: Lanthipeptide_LanB_RRE; Location: 174 - 240; Score: 36.1

TFBS definitions

Regulator	Description
AfsR	Pleiotropic regulatory for antibiotic production
IolR	Regulator of the inositol catabolism
MogR	Repressor of flagellar motility genes
RpoN	Regulator of nitrogen assimilation and virulence
RutR	Regulator of the pyrimidine and purine metabolism

NZ_CP070896.1 - Region 6 - ranthipeptide

Download region GenBank file

Download region SVG

Location: 2,048,110 - 2,069,779 nt. (total: 21,670 nt) Show pHMM detection rules used

ranthipeptide: (TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085 or SPASM)) and minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716 or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or (YcaO or TIGR03604))))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Oxidoreductases: dehydrogenase

JWH23_RS11405: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: glycosyltransferase

JWH23_RS11485: sugar transferase

smcogs: SMCOG1146: sugar transferase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000742.3	0.47	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.3	0.47	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0002306.2	0.46	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000231.5	0.44	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000741.3	0.44	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000744.3	0.44	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000745.3	0.44	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.41	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002276.2	0.55	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000742.3	0.47	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000743.3	0.47	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0002306.2	0.46	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000231.5	0.44	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000741.3	0.44	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000744.3	0.44	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0000745.3	0.44	saccharide	capsular polysaccharide	Streptococcus agalactiae
BGC0001605.3	0.42	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0001197.5	0.41	PKS	frankiamicin	Frankia sp. EAN1pec

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.29 out of 30.25

Confidence: medium

CcpA

Description: Catabolite control protein A
Species: Streptococcus & Clostridium sp.
Score: 18.05 out of 20.97

Confidence: medium

Additional weak hits (3):

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 22.68 out of 28.14

Confidence: weak

HgtR

Description: Hydrogen-dependent regulator
Species: Geobacter sulfurreducens PCA
Score: 24.62 out of 36.54

Confidence: weak

LexA variant 3

Description: Repressor of DNA damage response
Species: Escherichia coli str. K-12 substr. MG1655
Score: 23.65 out of 32.93

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Ranthipeptide_rSAM_RRE; Location: 0 - 111; Score: 85.4

TFBS definitions

Regulator	Description
CcpA	Catabolite control protein A
ColR	Phenol-responsive regulator
ToxT	Regulator of MSHA biosynthesis

NZ_CP070896.1 - Region 7 - RRE-containing

Download region GenBank file

Download region SVG

Location: 3,821,496 - 3,843,043 nt. (total: 21,548 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

JWH23_RS21230: Pseudouridine synthase

smcogs: SMCOG1154: Pseudouridine synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.50	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002116.3	0.43	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000590.5	0.41	ribosomal	microcin N	Escherichia coli
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000626.3	0.41	ribosomal	thuricin	Bacillus thuringiensis
BGC0000519.4	0.40	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000802.5	0.40	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000515.4	0.40	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002306.2	0.50	ribosomal	freyrasin	Paenibacillus polymyxa ATCC 842
BGC0000623.3	0.43	ribosomal	plantaricin W α, plantaricin W β	Lactobacillus plantarum
BGC0002116.3	0.43	ribosomal	darobactin A	Photorhabdus khanii HGB 1456
BGC0000590.5	0.41	ribosomal	microcin N	Escherichia coli
BGC0000504.5	0.41	ribosomal	cytolysin ClyLl, cytolysin ClyLs	Plasmid pAD1
BGC0000626.3	0.41	ribosomal	thuricin	Bacillus thuringiensis
BGC0000519.4	0.40	ribosomal	labyrinthopeptin A2, labyrinthopeptin A1, labyrinthopeptin A3	Actinomadura namibiensis
BGC0000802.5	0.40	saccharide	succinoglycan	Sinorhizobium meliloti
BGC0002698.2	0.40	ribosomal	phaeornamide	Pseudophaeobacter arcticus DSM 23566
BGC0000515.4	0.40	ribosomal	geobacillin I	Geobacillus thermodenitrificans NG80-2

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 28.14 out of 28.14

Confidence: strong

MogR

Description: Repressor of flagellar motility genes
Species: Listeria monocytogenes EGD-e
Score: 23.43 out of 26.06

Confidence: medium

NtrC

Description: Nitrogen regulatory protein C
Species: Pseudomonas putida KT2440
Score: 22.03 out of 29.72

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.44 out of 28.14

Confidence: medium

PerR

Description: Peroxide regulator
Species: Bacillus & Staphylococcus sp.
Score: 25.52 out of 28.14

Confidence: medium

Additional weak hits (9):

PsrA

Description: Oleic acid responsive regulator
Species: Pseudomonas sp.
Score: 19.97 out of 25.88

Confidence: weak

FuR variant 1

Description: Ferric Uptake Regulator
Species: Bacillus, Pseudomonas, Yersinia sp.
Score: 23.51 out of 29.38

Confidence: weak

FuR variant 2

Description: Ferric Uptake Regulator
Species: Caulobacter crescentus CB15
Score: 23.40 out of 32.74

Confidence: weak

HexR

Description: Glucose-responsive regulator
Species: Shewanella oneidensis MR-1
Score: 24.82 out of 31.73

Confidence: weak

RicR

Description: Copper-responsive regulator
Species: Mycobacterium tuberculosis H37Rv
Score: 21.14 out of 32.93

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 24.53 out of 33.14

Confidence: weak

NrtR

Description: NAD synthesis repressor
Species: Streptomyces coelicolor
Score: 24.21 out of 35.63

Confidence: weak

ArgR

Description: Regulator of arginine biosynthesis genes
Species: Streptomyces coelicolor
Score: 17.68 out of 20.01

Confidence: weak

CsoR

Description: Copper-responsive repressor
Species: Streptomyces lividans
Score: 21.84 out of 32.38

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Other_Sactipeptide_rSAM_RRE; Location: 19 - 102; Score: 47.0

TFBS definitions

Regulator	Description
MogR	Repressor of flagellar motility genes
NtrC	Nitrogen regulatory protein C
PerR	Peroxide regulator

NZ_CP070896.1 - Region 8 - RRE-containing

Download region GenBank file

Download region SVG

Location: 3,911,482 - 3,931,772 nt. (total: 20,291 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

reset view

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Ligases: synthase

JWH23_RS21715: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.5	0.33	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0001859.4	0.30	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0001524.3	0.24	NRPS, PKS	barnesin A	Sulfurospirillum barnesii SES-3
BGC0000383.5	0.22	NRPS, PKS	luminmycin A, glidobactin A, cepafungin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002440.3	0.19	NRPS	longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000904.5	0.33	other (other)	FR-900098	Streptomyces rubellomurinus
BGC0001859.4	0.30	other (phosphonate)	fosfomycin	Pseudomonas syringae
BGC0001524.3	0.24	NRPS, PKS	barnesin A	Sulfurospirillum barnesii SES-3
BGC0000383.5	0.22	NRPS, PKS	luminmycin A, glidobactin A, cepafungin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002440.3	0.19	NRPS	longicatenamide B, longicatenamide C, longicatenamide A, longicatenamide D	Streptomyces sp.

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

IolR

Description: Regulator of the inositol catabolism
Species: Caulobacter crescentus CB15
Score: 19.68 out of 23.79

Confidence: medium

ZuR variant 1

Description: Zinc-responsive repressor
Species: Streptomyces coelicolor
Score: 21.53 out of 28.19

Confidence: medium

Additional weak hits (3):

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 22.27 out of 30.25

Confidence: weak

MntR

Description: Manganese transport regulator
Species: Escherichia coli str. K-12 substr. MG1655
Score: 24.65 out of 39.62

Confidence: weak

ZuR variant 2

Description: Zinc-responsive repressor
Species: Pseudomonas protegens Pf-5
Score: 23.17 out of 33.14

Confidence: weak

RREFinder

TFBS Finder

RRE predictions

: RRE type: Stand_Alone_Lasso_RRE; Location: 5 - 93; Score: 32.0

TFBS definitions

Regulator	Description
IolR	Regulator of the inositol catabolism
ZuR variant 1	Zinc-responsive repressor

NZ_CP070896.1 - Region 9 - terpene-precursor

Download region GenBank file

Download region SVG

Location: 4,052,654 - 4,073,541 nt. (total: 20,888 nt) Show pHMM detection rules used

terpene-precursor: (PT_FPPS_like and not PT_HPP)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

Terpene

TFBS Finder

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Lyases: cyclase

JWH23_RS22485: diguanylate cyclase

smcogs: SMCOG1025: diguanylate cyclase

Ligases: synthetase

JWH23_RS22505: Polyprenyl synthetase

smcogs: SMCOG1182: Polyprenyl synthetase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.50	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.50	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001605.3	0.38	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000640.3	0.36	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0001227.3	0.36	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000663.5	0.36	terpene	hopene	Streptomyces coelicolor A3(2)

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002283.2	0.50	terpene	sodorifen	Serratia plymuthica
BGC0001361.3	0.50	terpene	sodorifen	Serratia plymuthica 4Rx13
BGC0002397.2	0.47	terpene	astallatene	Arabidopsis thaliana
BGC0002400.2	0.44	terpene	boleracene	Brassica oleracea var. oleracea
BGC0002398.2	0.38	terpene	(-)-ent-quiannulatene	Arabidopsis thaliana
BGC0000665.5	0.38	other (other), terpene	xiamycin, indosespene, sespenine, dixiamycin A, dixiamycin B, sulfadixiamycin A, sulfadixiamycin B, sulfadixiamycin C	Streptomyces sp. HKI0576
BGC0001605.3	0.38	terpene	gibberellin	Sinorhizobium fredii NGR234
BGC0000640.3	0.36	terpene	carotenoid	Enterobacteriaceae bacterium DC404
BGC0001227.3	0.36	terpene	isorenieratene	Streptomyces collinus Tu 365
BGC0000663.5	0.36	terpene	hopene	Streptomyces coelicolor A3(2)

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Detailed terpene predictions

Product predictions:

Class	Subclass	Product name	Chain length	Initial cyclisations	Functional groups
sesquiterpene precursor		FPP	C15	acyclic	PP

Genes with terpene domains:

JWH23_RS22505: PT_FPPS_like

Domain 1 (32 - 294): Prenyltransferase; Farnesyl diphosphate synthase like

Subtype: Farnesyl diphosphate synthase, bacterial

Reactions:: DMAPP, IPP → FPP

Transcription Factor Binding Sites

Binding sites found:

ANR

Description: Anaerobic transcriptional regulator
Species: Pseudomonas putida KT2440
Score: 22.87 out of 26.33

Confidence: medium

ColR

Description: Phenol-responsive regulator
Species: Pseudomonas putida KT2440
Score: 24.44 out of 30.25

Confidence: medium

Additional weak hits (1):

NrdR

Description: Represses ribonucleotide reductase encoding genes
Species: Streptomyces coelicolor
Score: 20.55 out of 27.18

Confidence: weak

Terpene

TFBS Finder

Glossary

Acronym	Full name
DMAPP	Dimethylallyl diphosphate
FPP	Farnesyl diphosphate
IPP	Isopentenyl diphosphate
PP	Diphosphate

TFBS definitions

Regulator	Description
ANR	Anaerobic transcriptional regulator
ColR	Phenol-responsive regulator

NZ_CP070896.1 - Region 10 - NRPS,NRPS-like

Download region GenBank file

Download region SVG

Location: 4,934,863 - 4,982,501 nt. (total: 47,639 nt) Show pHMM detection rules used

NRPS: cds(Condensation and (AMP-binding or A-OX) and not alpha_am_amid)
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

binding site

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Gene details

Select a gene to view the details available for it

Gene overview

Tailoring

MIBiG comparison

KnownClusterBlast

SubClusterBlast

TFBS Finder

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

Tailoring functions

Transferases: PPTase aminotransferase methyltransferase

JWH23_RS27205: methyltransferase

smcogs: SMCOG1089: methyltransferase

JWH23_RS27215: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

JWH23_RS27225: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Hydrolases: esterase

JWH23_RS27220: thioesterase

smcogs: SMCOG1004: thioesterase

Ligases: ligase

JWH23_RS27180: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

JWH23_RS27185: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

JWH23_RS27190: condensation domain-containing protein

smcogs: SMCOG1127: condensation domain-containing protein

JWH23_RS27200: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.61	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.61	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.61	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.61	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.60	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.59	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.59	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.58	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.58	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.57	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001641.4	0.64	NRPS	kolossin	Photorhabdus laumondii subsp. laumondii TTO1
BGC0001825.4	0.64	NRPS	xenematide	Xenorhabdus nematophila AN6/1
BGC0001833.4	0.64	NRPS	icosalide A, icosalide B	Burkholderia gladioli
BGC0001128.4	0.64	NRPS	gamexpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002286.3	0.64	NRPS	ririwpeptide A, ririwpeptide B, ririwpeptide C	Photorhabdus laumondii subsp. laumondii TTO1
BGC0002135.2	0.63	NRPS	bovienimide A	Xenorhabdus bovienii SS-2004
BGC0000307.4	0.63	NRPS	AbT1	Aureobasidium pullulans
BGC0001132.4	0.63	NRPS	xenotetrapeptide	Xenorhabdus nematophila ATCC 19061
BGC0001166.5	0.63	NRPS	HC-toxin	Alternaria jesenskae
BGC0001240.4	0.62	NRPS	serinocyclin A, serinocyclin B	Metarhizium robertsii

Similar known clusters from MIBiG 4.0

No significant matches found.

Similar subclusters

No significant matches found.

Transcription Factor Binding Sites

Binding sites found:

ToxT

Description: Regulator of MSHA biosynthesis
Species: Vibrio cholerae O395
Score: 18.31 out of 18.57

Confidence: strong

GnfM

Description: Regulator of nitrogen-fixation genes
Species: Geobacter sulfurreducens PCA
Score: 21.29 out of 27.55

Confidence: medium

CodY

Description: Regulator of stationary phase and virulence in Gram-positive bacteria
Species: Bacillus, Lactococcus & Streptococcus sp.
Score: 22.00 out of 27.78

Confidence: medium

DmdR1

Description: Iron(II)-dependent repressor
Species: Streptomyces coelicolor
Score: 27.73 out of 36.53

Confidence: medium

Module view

Legend

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS products

NRPS/PKS substrates

TFBS Finder

Predicted core structure(s)

For candidate cluster 14, location 4934862 - 4982501:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 15, location 4934862 - 4978174:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 16, location 4939951 - 4982501:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Cys) + (Cys)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

JWH23_RS27180: fatty_acid

CAL_domain (143..422): fatty_acid

minowa: fatty_acid

Prediction, score:

fatty_acid: 84.9
NH2: 48.1
Acetyl-CoA: 21.3
shikimic_acid: 0.0
AHBA: 0.0

JWH23_RS27185: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (511..903): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: TDISFDLSVYDGNSMLSGDISLGGATEASVWSIY
Nearest Stachelhaus code(s):: Cys DLYNMSLVWK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

JWH23_RS27200: Cys

Search NORINE for peptide: strict or relaxed

AMP-binding (7..250): Cys

nrpys: Cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Small clusters prediction:: Polar, uncharged (aliphatic with -SH) (Cys)
Single AA prediction:: Polar, uncharged (aliphatic with -SH) (Cys)

Stachelhaus prediction details:

Stachelhaus sequence:: ---SFDLSVYDGNSMLSGDISLGGATEGSIWSIY
Nearest Stachelhaus code(s):: Cys DLYNMSLIWK (85% 8Å match)
Stachelhaus code match:: 100% (strong)

Link to PARAS substrate predictor

TFBS definitions

Regulator	Description
CodY	Regulator of stationary phase and virulence in Gram-positive bacteria
DmdR1	Iron(II)-dependent repressor
GnfM	Regulator of nitrogen-fixation genes
ToxT	Regulator of MSHA biosynthesis