LOCUS       NZ_CP070896            47639 bp    DNA     circular CON 17-JUN-2024
DEFINITION  Lacrimispora xylanisolvens strain ASCUSBR21 chromosome, complete
            genome.
ACCESSION   NZ_CP070896
VERSION     NZ_CP070896.1
KEYWORDS    RefSeq.
SOURCE      Lacrimispora xylanisolvens
  ORGANISM  Lacrimispora xylanisolvens
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Lacrimispora.
REFERENCE   1  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Hungatella xylanolytica ASCUSBR21
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) R&D, Ascus Biosciences, 6450 Lusk Blvd E209,
            San Diego, CA 92121, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-MAY-2019
            Assembly Method                   :: Canu v. 2.1.1
            Assembly Name :: Hungatella xylanolytica ASCUSBR21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017084465.1-RS_2024_06_17
            Annotation Date                   :: 06/17/2024 10:45:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,443
            CDSs (total)                      :: 6,353
            Genes (coding)                    :: 5,667
            CDSs (with protein)               :: 5,667
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 686
            CDSs (without protein)            :: 686
            Pseudo Genes (ambiguous residues) :: 0 of 686
            Pseudo Genes (frameshifted)       :: 599 of 686
            Pseudo Genes (incomplete)         :: 95 of 686
            Pseudo Genes (internal stop)      :: 24 of 686
            Pseudo Genes (multiple problems)  :: 30 of 686
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:11:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4934862
            Orig. end                         :: 4982501
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070896.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..47639
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="NRPS"
                     /product="NRPS-like"
                     /region_number="10"
                     /rules="cds(Condensation and (AMP-binding or A-OX) and not
                     alpha_am_amid)"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX) and not alpha_am_amid)"
                     /tool="antismash"
     cand_cluster    1..47639
                     /SMILES="NC(CS)C(=O)NC(CS)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="neighbouring"
                     /product="NRPS"
                     /product="NRPS-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..43312
                     /SMILES="NC(CS)C(=O)NC(CS)C(=O)O"
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="cds(Condensation and (AMP-binding or
                     A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..43312
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[20000:23312](+)"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      20001..23312
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(Condensation and (AMP-binding or A-OX)
                     and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS"
                     /protocluster_number="1"
     gene            361..1140
                     /locus_tag="JWH23_RS27090"
     CDS             361..1140
                     /GO_function="GO:0015267 - channel activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013237854.1"
                     /locus_tag="JWH23_RS27090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MIP/aquaporin family protein"
                     /protein_id="WP_277406978.1"
                     /transl_table=11
                     /translation="MKEKILIPCLAEFLGTFLFVSIGFASVAAMVLKMSDISYPFMAVC
                     WGGAITIAIYIVGGVSGAHLNPAVTAALVVWDGFDKKKAICYIAAQTLGAFCAAALVYY
                     LFSSGIRGMEEANGWVRGTAEGTGAMGIFVTGAAAGVSMLKAFINETVITAMLVLTIYA
                     VTDKENVSAPDPGIGDIAIGAIVIFCGIAFGPLTGFAMNPARDFGPRLFVMAAGWGKYG
                     LGSNLYGLIVPVFGPFLGGILGGGIYKKMIKPLREKM"
     gene            1160..1510
                     /locus_tag="JWH23_RS27095"
     CDS             1160..1510
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014900.4"
                     /locus_tag="JWH23_RS27095"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate formate lyase family protein"
                     /protein_id="WP_277406979.1"
                     /transl_table=11
                     /translation="MKQILNIGPEETSPRIQNLIDGLYKALPAVESERALLITKSYKET
                     EALPMVLRRAKALEYILENMTLVIRDSELIVGNLTTAPRSTQIFPEFSNKWLLDEFDSL
                     AQRKGDVFYHYR"
     gene            1470..2036
                     /locus_tag="JWH23_RS27100"
     CDS             1470..2036
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014900.4"
                     /locus_tag="JWH23_RS27100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate formate lyase family protein"
                     /protein_id="WP_277406980.1"
                     /transl_table=11
                     /translation="MHSVRVMFFTITDEVKNQLKECFTYWNGRTVNELATELMYDDTKT
                     AMNHNVFTVGNYYFNGVGHISVDYERVLKNGFSGIIKDAENALANLDKGCPDSIEKTHF
                     LNAVIITSKAAIRYSERFAVLAEKMAAEERDMKRAQELRVIAANCRKVPANPAENFYEA
                     LQSFWFVQAIIQIESNGHSISPHAF"
     gene            2068..3690
                     /locus_tag="JWH23_RS27105"
     CDS             2068..3690
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014900.4"
                     /locus_tag="JWH23_RS27105"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pyruvate formate lyase family protein"
                     /protein_id="WP_349773255.1"
                     /transl_table=11
                     /translation="MESLNLSKERAQELLDCLWVKFNDVNKVRDTGSTKGFGGYPMFQN
                     LIVGGQDRAGMDATNELSIACLEATQHTKLPQPSISIRVWNGSPHELLIKAAETSRLGL
                     GMPAYYNDEVIIPALVNRGLTLGDARDYGIIGCVEPQVGGKTEGWHDAAFFNLAKVLEL
                     VVYNGCLDGVRITPQTGEFTSFTSFGQILEAYQKQMEYCVRFLTNADNSVDMAHGQRAP
                     LPFVSSMVDDCIGKGKSIQCGGAHYNFTGPQGVGVANVGDSLMCIKELVFDKKKYTLAQ
                     IKQAMEDNFGGTSVEAVDAEILKEVVRRLTEGGKSLSPDQIARLAELTSQGITAKKASG
                     DYSSMLEDMENVPKFGNDIEEADDLARLSALVYCREVEKYRNVRGGQFQPGLYPVSANV
                     PMGEQTGAMPDGRKAGEPLADGVSPVSGRDTNGPTAAANSVAHLDHMIVSNGTLFNQKF
                     HPSALSGREGLEKLSALVRGFFDKKGMHVQYNVVGRETLVDAQNHPDQYKNLVVRVAGY
                     SAHFIYLDKSLQDDIINRTEQIF"
     gene            3709..4497
                     /locus_tag="JWH23_RS27110"
     CDS             3709..4497
                     /EC_number="1.97.1.-"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0043687 - post-translational protein
                     modification [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QueE"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005212585.1"
                     /locus_tag="JWH23_RS27110"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="glycyl-radical enzyme activating protein"
                     /protein_id="WP_277406981.1"
                     /sec_met_domain="Fer4_12 (E-value: 2.3e-14, bitscore: 52.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 5.5e-25, bitscore: 87.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="QueE (E-value: 6.8e-06, bitscore: 24.2,
                     seeds: 32, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQGIYDAKGIVSEIQRFSVHDGPGIRTLVFLKGCPLRCKWCCNPE
                     NLSREPQYMLVQGKQKLIGKEMTVEEVMREIRKDMIYYYRSHGGLTISGGEVLMQPLFA
                     RSLLEACKSEGISTAIETSAFAEYEVIEQLLPWLDVALCDIKHVDEEKHLKFTGLSNRG
                     ILENIRKIGLSKTELIVRVPVVPGFNNTEKEIEMISTYAASIQGVKRLHLLPYHRLGEA
                     KYEGLGEDYSLKGIEPMNSEQMERLLKIARMSGLECQIGG"
     gene            complement(4597..5004)
                     /locus_tag="JWH23_RS27115"
     CDS             complement(4597..5004)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS27115"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277406982.1"
                     /transl_table=11
                     /translation="MRKEKYLYLYLLLFLLMTIGAFVWQMFFPNVAETFSVWRMSRGWQ
                     AEIALWNVGIDMGIVITLIRRNIEYAKILSLISVVLCILLGGHHLIYAVTTTNGNITLH
                     WMGAIEVLLIGGGVGIFALIKSNCFKKDARY"
     gene            complement(5051..5896)
                     /locus_tag="JWH23_RS27120"
     CDS             complement(5051..5896)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1171:
                     transcriptional regulator, MerR family"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004619658.1"
                     /locus_tag="JWH23_RS27120"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MerR family transcriptional regulator"
                     /protein_id="WP_277406983.1"
                     /transl_table=11
                     /translation="MRTVKEVSELTGVSTRTLHYYDEIGLFPPTDKSEAGYRLYDDRAL
                     EILQQILFFREFCIPLKDIKTILENPSLDRNQILQMQREMLVEKKERMERLIASIDKVL
                     KGDNKMDFSVFTKTEIEKMFQLMFNSMPEEMRQTAIGEFGSLEHWKKHYIEAVSSEDMQ
                     KRYAKVVEWYGGKDAYLSTLENPISKEVAESYKKREDTIRKKLIEKRGSDLNSFEVKAI
                     IGEYGFVMKQVCQMKEEEGLMLAVAQSYRNRQCQQAINEEYGEGAAEFFAQAIEAFYCD
                     "
     cand_cluster    5090..47639
                     /SMILES="NC(CS)C(=O)NC(CS)C(=O)O"
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /kind="single"
                     /product="NRPS-like"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    5090..47639
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="False"
                     /core_location="[25089:27639](+)"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      25090..27639
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX) and not alpha_am_amid)"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="2"
     gene            6068..6552
                     /gene="nuoE"
                     /locus_tag="JWH23_RS27125"
                     /pseudo=""
     CDS             6068..6552
                     /GO_function="GO:0016491 - oxidoreductase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="nuoE"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008909762.1"
                     /locus_tag="JWH23_RS27125"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit NuoE"
                     /pseudo=""
                     /transl_table=11
                     /translation="MESKCDTQEKFKDLQKFIDSMEDRRGALIAVLHKAQHLYGYLSND
                     VIFLLLKNLRSPVRKCLVSLAFTLTLPQSQEVSM"
     gene            6552..6947
                     /locus_tag="JWH23_RS27130"
     CDS             6552..6947
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008909763.1"
                     /locus_tag="JWH23_RS27130"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="(2Fe-2S) ferredoxin domain-containing protein"
                     /protein_id="WP_277406984.1"
                     /transl_table=11
                     /translation="MAKLKTVEELKKIRQAALDQLDLRSTAESEDKILVRVGMATCGIA
                     SGARTTMKAILDEIAKQGLANVSVTQTGCIGYCAQEPVVEVISKGMPSVLYGKVDENRG
                     REIVIEHIKNGRLLQNAIINKSFENME"
     gene            6960..8753
                     /locus_tag="JWH23_RS27135"
     CDS             6960..8753
                     /EC_number="7.1.1.-"
                     /GO_function="GO:0010181 - FMN binding [Evidence IEA]"
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008909764.1"
                     /locus_tag="JWH23_RS27135"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-quinone oxidoreductase subunit NuoF"
                     /protein_id="WP_277406985.1"
                     /transl_table=11
                     /translation="MSNFRMHLLVCGGTGCTASDSLKLVKMLKESIKKHEITNEVEVVV
                     TGCFGFCEKGPILKVYPDNVFYITVKPEDAEEIITEHVIKGRKVERLLYVEPNTKKRLE
                     GQKSIPFYKKQIRIALRNCGFINPEDINEYIAADGYQALAKCLTEMSPEEVIDTVVQSG
                     LRGRGGGGYPTGLKWKYTRQSQSDEKYIICNADEGDPGAFMDRSILEGDPHSVLEAMAI
                     AGYAIGAQYGYIYIRAEYPLAINRLEIAIKQARKLGLLGEDIFSTGFNFDIGLRYGAGA
                     FVCGEETALIHSVEGKRGEPSSKPPFPAQRGVWDKPSCVNNVETFANIPPIFLKGPAWF
                     KSIGTEKSPGTKVFALAGKVNNVGLVEVPMGITLREVIYDIGGGIKNNKKFKAVQTGGP
                     SGGCITKENLDIPIDYESLNSIGSMMGSGGMIVMDEDNCMVDIAKFYLEFTKDESCGKC
                     TPCRIGNTRMLEILEKITKGNGTEQDLKDLVELGDVIKDTSLCGLGQTSPNPVLSTLHY
                     FEDEYLAHVKDKHCPAGVCQALFSFHILPDKCVGCTACARICPAHCIEGERKIVHVIDQ
                     SRCIKCSACYNTCKFNAIEKG"
     gene            8768..10510
                     /locus_tag="JWH23_RS27140"
     CDS             8768..10510
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer2_4"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_007060145.1"
                     /locus_tag="JWH23_RS27140"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="NADH-dependent [FeFe] hydrogenase, group A6"
                     /protein_id="WP_277406986.1"
                     /sec_met_domain="Fer2_4 (E-value: 1.5e-19, bitscore: 68.4,
                     seeds: 114, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLVHVTINNQTIAVEEGTTILEAAKKLDIRIPTLCYLNLEHVKT
                     VNGSASCRVCVVEIEGRRNLAPSCATPVSEGMVVRTNTLRCIKARRLVVELLLSNHPTD
                     CLICEKNLNCELQSLAAELDIRRIKFHGARATHEKDISSKAMIRNMDKCILCRRCETMC
                     NQVQTVHVYSAVNRGFDTFIAPALNLPMDKSICTFCGQCVSVCPTAALTVVNDIPNVWE
                     ALNAKDKFVIVQTAPAVRVALGEKFGAEPGTVVTGKMVAALRMMGFDKVFDTDFAADLT
                     IMEEAAEFIHRLQHGGRLPILTSCCPGWVKFFEHQFNDLLDIPSTCKSPHEMFGVIAKT
                     YYAEKMGIDPKNIFVVSIMPCLAKKYEAARPELMHDDMQDVDAVLTTRELGDMLKEANI
                     DLMNLKDEEFDEPLGESTGASVIFGTTGGVIEAALRTTYEWLTNETLEEVEFHELRGFE
                     GIREAVVKINDQDINIAVAHGLGNARKLLEDIRAGKSHYHAIEIMACPGGCIGGGGQPY
                     HFGNFDVLKKRMEGIYKEDKSKKYRKSHENPAIKKLYEEYLGEPNGEKAHELLHTYYVK
                     RENR"
     gene            10688..11311
                     /locus_tag="JWH23_RS27145"
     CDS             10688..11311
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS27145"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277406987.1"
                     /transl_table=11
                     /translation="MTNFNVSRSSGVQYKSFSPTSKASAPDWERIPHKGMERPSEAEFN
                     AKIDELAKGLAEARLQNDSIQYENLSLEGDKLRAQYISAVSPDRKSMVKDAAEIMKQAK
                     AGRTDPEASMNLIDYINKKDGIEVVLSGSDLQPDTFEIKESKMGQAVMGYASGNWHYAN
                     TPQEQAMQQTFLSRLNKTEDRYYRQYVNGDIQEVSSHKNIDYTV"
     gene            complement(11364..12947)
                     /locus_tag="JWH23_RS27150"
     CDS             complement(11364..12947)
                     /GO_function="GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012609.4"
                     /locus_tag="JWH23_RS27150"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP-utilizing enzyme"
                     /protein_id="WP_277406988.1"
                     /transl_table=11
                     /translation="MGHLPEQVIFVAGTSNHHAERKNSTDIQLTKSQRAVLNNWIEHCP
                     NPLYPLDVKPCLIVDEAKNKVFHELGISVESELTMADNGLLSLSAGKIHISPKVLKIPF
                     LLSSFNNYSINSARTNDSFHNIRKELFSKERADLSALPVKALIRQIMELMELSKELAYT
                     RFRYNIFPSVGISKLILHDLKKIDKNMSEYDLLSNLSYKTWDLNLKLKKLSAYIQSTPG
                     LEQLFMELDRTNPQAIQDFLENQPDFKAKLQSFLNEFGWKSSSSYCAFGSESWFENLDS
                     LFSMLKVLQSSGRNDDSPVKFQNIMTKITTTFSKKKADRLKTKIEEIRAYHVNREESLY
                     MIEMCYGLARRAAFELAKRFPQLFEQAEDIRYLTLDEVYELPGNIADLKELISVRKNNR
                     HKNEVLWSGFSIGTKAGHQNTLSGVSGNGGRCRGRVRKILTQQEFDKMQSGDILLCRYT
                     DPSWTPLFVLASAVISDTGGPLSHSAIVAREYNIPAVLGIGNATDVLEDGDEVYVYGDT
                     GKVILLTKKI"
     gene            complement(12836..13540)
                     /locus_tag="JWH23_RS27155"
     CDS             complement(12836..13540)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.4"
                     /locus_tag="JWH23_RS27155"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_277406989.1"
                     /sec_met_domain="PPDK_N (E-value: 1.8e-78, bitscore: 262.6,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQTTIMLWGANSKVAVRSSATAEDLPEASFAGQQETYLNIEGLDQ
                     LYLSVRKCFASLFSSRATAYRKQTNFDTGKISLSVVVQRMVNSEISGVLFTIDPISKNK
                     SRMMLNASWGLGESIVSGKVTPDIYVYDRNHRQIVEKRLGDKKIMVCYSAEGTEERETS
                     SQQRREFSLTDKQAIEIFELGRKTEQHFQCPQDMEWAISQNRLYLLQARPITTLNVKTA
                     LISSLQNLSEPY"
     gene            complement(13425..15092)
                     /locus_tag="JWH23_RS27160"
     CDS             complement(13425..15092)
                     /GO_function="GO:0022857 - transmembrane transporter
                     activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF019310.4"
                     /locus_tag="JWH23_RS27160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MFS transporter"
                     /protein_id="WP_277406990.1"
                     /sec_met_domain="PPDK_N (E-value: 8e-10, bitscore: 37.0,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKLSKKITILTGLLLCMGASTVMQTYFSSALPAISRQFQSTAFYS
                     WVHVSYILASSAVILLSSSLCERFGNKNNFIAGSLLFGIGTLAAPFSSSMLQLIAARII
                     MGIGAGIVVPATYGIIGDQFEKSSYASIFAAFAVVQIITNGLGSLAGGYLPQLATWQTI
                     FIILLPIEIISFLLVFRNISAKADPLTKSPLKLQRHILMITAILLLTLGIEFAYRSQYF
                     LLLAGMALLFLVVIKDTQKDNAILPKEFLSDSLLRNLCLQIFLLGAFYNICLAYLPGIM
                     QFTLHMNPDRSGTLLTVFVFAMGIGSVAGGAAKHKEREMIAIGWITCLAGSLLMKSFIV
                     FALTALGLGSGILMSALLGYAANRTVHHAAGVNSMAHLIRNLGGSLGAILFQFTLHFPE
                     NYFIAGITIIALSGTASILLAFKYKPGKTLKKEEALSMKYVMKFSEIRKEDILAAGGKG
                     ANLGELFNAGFPVPEGFSITSHAFDEYMKRNGFNSASSGDTLTSEEVAKGQLWKELEDE
                     IADYYHALGGQFKSCRTFLCNSRGPAGSKLCRTAGNLS"
     gene            complement(15175..15750)
                     /locus_tag="JWH23_RS27165"
     CDS             complement(15175..15750)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012655.4"
                     /locus_tag="JWH23_RS27165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_277406991.1"
                     /transl_table=11
                     /translation="MGRPYTEEEREELKRKIKNIASLMFMEEGFKNCKIQEITKKAGIS
                     MGGFYTFYKDKEALYEEILRDETNRIRQKILTIIDEENQTPQAFFSDLANVFLEKTSTN
                     KFYTSEYSGLLESMVWNNDTYASQDNLDFIKKLKHIWAGKGYFLKASEEEIASAVAVLA
                     VLCMQKEMIGNGFSFWYEKIQKLILDLI"
     misc_feature    complement(15757..15773)
                     /note="TFBS match to GnfM, Regulator of nitrogen-fixation
                     genes, confidence: medium, score: 21.29"
                     /tool="antismash"
     gene            16185..17174
                     /locus_tag="JWH23_RS27170"
     CDS             16185..17174
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00881"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013077.4"
                     /locus_tag="JWH23_RS27170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SagB/ThcOx family dehydrogenase"
                     /protein_id="WP_170072344.1"
                     /sec_met_domain="PF00881 (E-value: 4.5e-14, bitscore: 51.4,
                     seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIYYWSPGVQFYVKEEELYVERFRYGRQAAQFFPEFYYMAQNG
                     AGTDDLEKRFETDNKSLLKNLIQDFIKKKILVCSVITPKELFHSQTRLFENDYPETIRF
                     VKEELEEFKKEQSGRELVKDGLTYILKDSYYCNDIIYRETVRKFSKKPITYHSFSRILG
                     ALQNREDRKGTRYYPSAGGLYPVDVYVLVKPGRVEGVEQGLYYYNPVINGITLVDKGEN
                     ITDKSQFITNQEIFSGSAFTIYFLYNARCSMPKYSGMGYYYGILDCGIMTGLITRISEE
                     EGIGTCSIGDMLYGKIESCFHLNKSQLFLHSMECGYKDEAESEQPKEK"
     gene            17176..17472
                     /locus_tag="JWH23_RS32900"
     CDS             17176..17472
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012991.4"
                     /locus_tag="JWH23_RS32900"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_349772713.1"
                     /transl_table=11
                     /translation="MSFKPLHNMPSPEQLREECPVSCKLAARKLERDRELAAVIQNQTN
                     KFLVIVGPCSASNEDAVCDYASRLSKVNQKLNQKLFYYSADLYSQTKNQWIRL"
     gene            17432..18205
                     /locus_tag="JWH23_RS27175"
     CDS             17432..18205
                     /EC_number="2.5.1.54"
                     /GO_function="GO:0003849 - 3-deoxy-7-phosphoheptulonate
                     synthase activity [Evidence IEA]"
                     /GO_process="GO:0009423 - chorismate biosynthetic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:TIGR00034.1"
                     /locus_tag="JWH23_RS27175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="3-deoxy-7-phosphoheptulonate synthase"
                     /protein_id="WP_349773256.1"
                     /transl_table=11
                     /translation="MYTAKPRTNGYGYKGILHYPETSTHSDLVKGLRAARNLHLRVAGE
                     SGLTTADELLYPEAFAYFQDIVSYLAIGARSVEDQQHRFVSSGVDCPVGMKNPTNGNPD
                     TLFYSIFAAQHGHKFIYRDREVKSSGNPLAHAIIRGYENIMGEYVPNYQYEQLLKIGER
                     YRKQKLKNPFIICDVNHANSGKDYSREPMIIYDVLESRRRSEEIRMIVRGVMIESFIEA
                     GRQEISGTVYGKSVTDGCLGWNETEELLHYIAEHV"
     gene            18316..19995
                     /locus_tag="JWH23_RS27180"
     CDS             18316..19995
                     /NRPS_PKS="Domain: CAL_domain (143-422). E-value: 2.2e-77.
                     Score: 252.0. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27180_CAL_domain.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="JWH23_RS27180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_277406992.1"
                     /sec_met_domain="AMP-binding (E-value: 4.4e-79, bitscore:
                     264.5, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTVILFFADRKGEESRLRFKEIRKKAKQLGCVMLEMGMKKGDKLV
                     FQISDPQSFIISFWACLYTGIIAVPITTAAEIKTANINKKLEAVLEKLEWPRLILEEEL
                     LCTLGEDVKARGNILIYEEMKKQAESSILLFCPEQITGEDTAYIQFSSGSTNSPKGVVL
                     KHSNIIYNVEQIGRRLNLTEKDVSESWMPLTHDMGLVGFHITTFCRGMNQIILSPMNFI
                     KNPTYFYQKVKEYKTTIMGMPNFAFDWSVKMVKEKHLRTLDLSSIRAVLNGAEPINIHS
                     IQRFNERFAACGLDPNAMLPVYGMAEACIGVTIPHCGDRLVEVKKSPAEKKGYVAVGEP
                     LDGIDVKITDENEEILEDGQIGDILIHGPNLTCGYYDSALINEESFSNGYLKTGDMGFI
                     KNGRLFITGRKKDMFFINGQNCYLSDLDIVLSESGIKDCAAVYDDEENELIVFVKHLGI
                     GEKALETERKIKEVVQRTFQISVRSVLTVNNIPKTTSGKVQRYHLLNDYRKTFKNNEII
                     WGKREEGSTISEPLARMWRQILDAEPADTNSFFDLGGEIPLN"
     aSDomain        18745..19581
                     /aSDomain="CAL_domain"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27180_CAL_domain.1"
                     /evalue="2.20E-77"
                     /label="JWH23_RS27180_CAL_domain.1"
                     /locus_tag="JWH23_RS27180"
                     /protein_end="422"
                     /protein_start="143"
                     /score="252.0"
                     /specificity="Minowa: fatty_acid"
                     /tool="antismash"
                     /translation="DTAYIQFSSGSTNSPKGVVLKHSNIIYNVEQIGRRLNLTEKDVSE
                     SWMPLTHDMGLVGFHITTFCRGMNQIILSPMNFIKNPTYFYQKVKEYKTTIMGMPNFAF
                     DWSVKMVKEKHLRTLDLSSIRAVLNGAEPINIHSIQRFNERFAACGLDPNAMLPVYGMA
                     EACIGVTIPHCGDRLVEVKKSPAEKKGYVAVGEPLDGIDVKITDENEEILEDGQIGDIL
                     IHGPNLTCGYYDSALINEESFSNGYLKTGDMGFIKNGRLFITGRKKDMFFINGQNCY"
     CDS_motif       18751..18810
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27180_0001"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="JWH23_RS27180"
                     /protein_end="165"
                     /protein_start="145"
                     /score="22.4"
                     /tool="antismash"
                     /translation="AYIQFSSGSTNSPKGVVLKH"
     CDS_motif       19387..19446
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27180_0002"
                     /evalue="4.70E-04"
                     /label="NRPS-A_a6"
                     /locus_tag="JWH23_RS27180"
                     /protein_end="377"
                     /protein_start="357"
                     /score="12.6"
                     /tool="antismash"
                     /translation="DGQIGDILIHGPNLTCGYYD"
     gene            20001..23312
                     /locus_tag="JWH23_RS27185"
     CDS             20001..23312
                     /NRPS_PKS="Domain: Heterocyclization (53-340). E-value:
                     1.7e-60. Score: 196.8. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27185_Heterocyclization.1"
                     /NRPS_PKS="Domain: AMP-binding (511-903). E-value: 1.9e-86.
                     Score: 282.2. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27185_AMP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (1010-1074). E-value:
                     5.4e-15. Score: 47.5. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27185_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters) NRPS:
                     Condensation"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR01733.1"
                     /locus_tag="JWH23_RS27185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="amino acid adenylation domain-containing protein"
                     /protein_id="WP_277406993.1"
                     /sec_met_domain="Condensation (E-value: 2.4e-40, bitscore:
                     137.0, seeds: 42, tool: rule-based-clusters)"
                     /sec_met_domain="AMP-binding (E-value: 1.5e-77, bitscore:
                     259.5, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 2.8e-13, bitscore:
                     48.7, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLSEIEETFGVEIEVEDFLKQPYFTYLNTCVSEKKDTVRNDAADK
                     KIRELPDTIPATELQKAYLIGREEGIATKVLYELSTSWEIDRLEKAVNCMIRSQPALRL
                     RISREGVMHADKTGDWYCIKTMDLSHMTEEEKANALDQEFELQKRKVFDTEKEPLFTIQ
                     AIKMRAGDTRLLIQMDMLIADGMSLKLFVDGIADYYQHENQSDQEDPRFFLYCLEKQEE
                     KHSRQYNKDRMYWLDRLEQFPSAPPLAVNHIPQENTQGFGRKTVTIDKPSWDKIKEELK
                     KYSVTPSVLIMSLYAKILGLYSGSSRFTLNVPVFNRKSTRGMIDAIGDFTSVLLLDIDL
                     SRENLLDLCTSVQKKNMLEALMHKSFDGIEFMREIAKVRGTKEASFPVVFTSLLSDAFE
                     LNLDKIGRMVRGYSQTSQVELDCQAYEEKGSLVINWDYKKGVFEGNILERMFSLFYYDL
                     AGLCTDTGFSSGISDRGFLKRLLHQDIEMIHAYNTTEEDIPYVSLNQLLIQAYGKYKDK
                     AILSCGEKTMSYERLWEKSGRVKNYLKMKGVKAGSNVAVIGTRDFDTVINILGVIRSGA
                     AYIPIDEIQPEERRKLILEKSSSSVILERNMDYTHFEDDGEQEEPVSSPDDIAYIIFTS
                     GSTGQPKGVYVKHGAVVNTILDINRKFQVSDQDVIACVSSIGFDLSVYDIFGALISGAE
                     LALIPDVHDTEQMMTILSERGVTVWNSVPALFQMLTDCLKNDRSESEEYFDDYLESGDT
                     FRRLLSLKLVMLSGDWIPKNLIQEAYGYFENCRMISLGGATEASVWSIYYDIKEVKNQW
                     TSIPYGYPLANQNIYLLDEVDDFVPVGVKGQICIGGIGVAEGYYQDQEKTDAAFCKKEG
                     LGRIYHTGDYGVFSEEGCILFLGRKDGQIKINGFRIELGEIENAIKGLPYVSNAAALVH
                     EYKSGVKSVCAYVCTSETISERKVRDDLSSILPYYMIPSTVVFLERIPLTGNGKLDRKS
                     LPVIKEPGELMDREPQTQTQKDLYEIWKKYLKTDHLSVSRPFMELGGDSLTMISVVHEI
                     KSKFGLEVPFREFMMGGSIESIAEFIESSRKKGAAGLREYTAVTGKQRKNMTAFR"
     aSDomain        20160..21020
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27185_Heterocyclization.
                     1"
                     /evalue="1.70E-60"
                     /label="JWH23_RS27185_Heterocyclization.1"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="340"
                     /protein_start="53"
                     /score="196.8"
                     /specificity="C activity: active"
                     /specificity="Active site motif: DMLIADG"
                     /tool="antismash"
                     /translation="IPATELQKAYLIGREEGIATKVLYELSTSWEIDRLEKAVNCMIRS
                     QPALRLRISREGVMHADKTGDWYCIKTMDLSHMTEEEKANALDQEFELQKRKVFDTEKE
                     PLFTIQAIKMRAGDTRLLIQMDMLIADGMSLKLFVDGIADYYQHENQSDQEDPRFFLYC
                     LEKQEEKHSRQYNKDRMYWLDRLEQFPSAPPLAVNHIPQENTQGFGRKTVTIDKPSWDK
                     IKEELKKYSVTPSVLIMSLYAKILGLYSGSSRFTLNVPVFNRKSTRGMIDAIGDFTSVL
                     LLDIDL"
     aSModule        20160..23222
                     /complete
                     /domains="nrpspksdomains_JWH23_RS27185_Heterocyclization.1"
                     /domains="nrpspksdomains_JWH23_RS27185_AMP-binding.1"
                     /domains="nrpspksdomains_JWH23_RS27185_PP-binding.1"
                     /locus_tags="JWH23_RS27185"
                     /monomer_pairings="Cys -> Cys"
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       20517..20561
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0001"
                     /evalue="5.70E-04"
                     /label="Cy3"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="187"
                     /protein_start="172"
                     /score="13.2"
                     /tool="antismash"
                     /translation="RLLIQMDMLIADGMS"
     CDS_motif       20922..20954
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0002"
                     /evalue="3.70E-04"
                     /label="afterCy4"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="318"
                     /protein_start="307"
                     /score="13.1"
                     /tool="antismash"
                     /translation="FTLNVPVFNRK"
     CDS_motif       20976..21017
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0003"
                     /evalue="3.10E-05"
                     /label="Cy5"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="339"
                     /protein_start="325"
                     /score="16.4"
                     /tool="antismash"
                     /translation="AIGDFTSVLLLDID"
     CDS_motif       21237..21308
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0004"
                     /evalue="1.30E-05"
                     /label="Cy7"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="436"
                     /protein_start="412"
                     /score="18.1"
                     /tool="antismash"
                     /translation="SQTSQVELDCQAYEEKGSLVINWD"
     aSDomain        21534..22709
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27185_AMP-binding.1"
                     /evalue="1.90E-86"
                     /label="JWH23_RS27185_AMP-binding.1"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="903"
                     /protein_start="511"
                     /score="282.2"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="GKYKDKAILSCGEKTMSYERLWEKSGRVKNYLKMKGVKAGSNVAV
                     IGTRDFDTVINILGVIRSGAAYIPIDEIQPEERRKLILEKSSSSVILERNMDYTHFEDD
                     GEQEEPVSSPDDIAYIIFTSGSTGQPKGVYVKHGAVVNTILDINRKFQVSDQDVIACVS
                     SIGFDLSVYDIFGALISGAELALIPDVHDTEQMMTILSERGVTVWNSVPALFQMLTDCL
                     KNDRSESEEYFDDYLESGDTFRRLLSLKLVMLSGDWIPKNLIQEAYGYFENCRMISLGG
                     ATEASVWSIYYDIKEVKNQWTSIPYGYPLANQNIYLLDEVDDFVPVGVKGQICIGGIGV
                     AEGYYQDQEKTDAAFCKKEGLGRIYHTGDYGVFSEEGCILFLGRKDGQIKIN"
     CDS_motif       21705..21746
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0005"
                     /evalue="1.60E-03"
                     /label="NRPS-A_a2"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="582"
                     /protein_start="568"
                     /score="12.0"
                     /tool="antismash"
                     /translation="LGVIRSGAAYIPID"
     CDS_motif       21885..21944
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0006"
                     /evalue="1.40E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="648"
                     /protein_start="628"
                     /score="30.0"
                     /tool="antismash"
                     /translation="AYIIFTSGSTGQPKGVYVKH"
     CDS_motif       22509..22598
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0007"
                     /evalue="3.00E-11"
                     /label="NRPS-A_a6"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="866"
                     /protein_start="836"
                     /score="35.6"
                     /tool="antismash"
                     /translation="PVGVKGQICIGGIGVAEGYYQDQEKTDAAF"
     CDS_motif       22674..22739
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27185_0008"
                     /evalue="6.10E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="913"
                     /protein_start="891"
                     /score="37.4"
                     /tool="antismash"
                     /translation="FLGRKDGQIKINGFRIELGEIE"
     aSDomain        23031..23222
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27185_PP-binding.1"
                     /evalue="5.40E-15"
                     /label="JWH23_RS27185_PP-binding.1"
                     /locus_tag="JWH23_RS27185"
                     /protein_end="1074"
                     /protein_start="1010"
                     /score="47.5"
                     /tool="antismash"
                     /translation="DLYEIWKKYLKTDHLSVSRPFMELGGDSLTMISVVHEIKSKFGLE
                     VPFREFMMGGSIESIAEFI"
     gene            23333..24355
                     /locus_tag="JWH23_RS27190"
     CDS             23333..24355
                     /GO_function="GO:0003824 - catalytic activity [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Heterocyclization (1-284). E-value:
                     5.6e-77. Score: 251.0. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27190_Heterocyclization.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Condensation"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1127: condensation domain-containing protein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012873.4"
                     /locus_tag="JWH23_RS27190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="condensation domain-containing protein"
                     /protein_id="WP_277406994.1"
                     /sec_met_domain="Condensation (E-value: 1.3e-44, bitscore:
                     151.0, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVGRSSGLKMGGVSTHAYYEVENDFDIPRLTRSLNKVICANPMLR
                     AVVNTDGTQQILENPGWFEIKELDLTRLTSEEKEEILGKAREEYSHKVFEQNKFPLFDF
                     LAYRLAEDRVRLLAGFDLLIADGISMRILIREVMRLYEDEHIVLSENTFTFRDYILSVE
                     EMKKSPYYKTAEDYWKKQAECFSGAPDLPMIQTPDEIEKPVFRRLIHKISTEKWQALKE
                     KIKGHSFTASTFLMTLYGRILAAYSNRNTVTLNVTVFTRFPFHQAVKNMIGDFTSVMLL
                     DINGESVELWEECLNVQRKITENLEHMEYDGVSVIREVSKRQNRVGGTFISFRFYRYDL
                     "
     aSDomain        23336..24184
                     /aSDomain="Heterocyclization"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27190_Heterocyclization.
                     1"
                     /evalue="5.60E-77"
                     /label="JWH23_RS27190_Heterocyclization.1"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="284"
                     /protein_start="1"
                     /score="251.0"
                     /specificity="C activity: active"
                     /specificity="Active site motif: DLLIADG"
                     /tool="antismash"
                     /translation="VGRSSGLKMGGVSTHAYYEVENDFDIPRLTRSLNKVICANPMLRA
                     VVNTDGTQQILENPGWFEIKELDLTRLTSEEKEEILGKAREEYSHKVFEQNKFPLFDFL
                     AYRLAEDRVRLLAGFDLLIADGISMRILIREVMRLYEDEHIVLSENTFTFRDYILSVEE
                     MKKSPYYKTAEDYWKKQAECFSGAPDLPMIQTPDEIEKPVFRRLIHKISTEKWQALKEK
                     IKGHSFTASTFLMTLYGRILAAYSNRNTVTLNVTVFTRFPFHQAVKNMIGDFTSVMLLD
                     IN"
     CDS_motif       23381..23473
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0001"
                     /evalue="1.70E-04"
                     /label="C2_LCL_024-062"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="47"
                     /protein_start="16"
                     /score="14.0"
                     /tool="antismash"
                     /translation="AYYEVENDFDIPRLTRSLNKVICANPMLRAV"
     CDS_motif       23456..23494
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0002"
                     /evalue="7.20E-05"
                     /label="Cy2"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="54"
                     /protein_start="41"
                     /score="15.3"
                     /tool="antismash"
                     /translation="PMLRAVVNTDGTQ"
     CDS_motif       23702..23755
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0003"
                     /evalue="1.10E-06"
                     /label="C3_LCL_132-143"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="141"
                     /protein_start="123"
                     /score="21.2"
                     /tool="antismash"
                     /translation="IADGISMRILIREVMRLY"
     CDS_motif       24020..24073
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0004"
                     /evalue="1.20E-03"
                     /label="Cy4"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="247"
                     /protein_start="229"
                     /score="12.0"
                     /tool="antismash"
                     /translation="TASTFLMTLYGRILAAYS"
     CDS_motif       24089..24121
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0005"
                     /evalue="1.30E-02"
                     /label="afterCy4"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="263"
                     /protein_start="252"
                     /score="8.5"
                     /tool="antismash"
                     /translation="TLNVTVFTRFP"
     CDS_motif       24125..24181
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0006"
                     /evalue="2.20E-07"
                     /label="Cy5"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="283"
                     /protein_start="264"
                     /score="23.1"
                     /tool="antismash"
                     /translation="HQAVKNMIGDFTSVMLLDI"
     CDS_motif       24245..24286
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27190_0007"
                     /evalue="3.30E-04"
                     /label="afterCy5"
                     /locus_tag="JWH23_RS27190"
                     /protein_end="318"
                     /protein_start="304"
                     /score="13.5"
                     /tool="antismash"
                     /translation="LEHMEYDGVSVIRE"
     gene            24345..25124
                     /locus_tag="JWH23_RS27195"
     CDS             24345..25124
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012711.4"
                     /locus_tag="JWH23_RS27195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AMP-binding protein"
                     /protein_id="WP_277406995.1"
                     /sec_met_domain="AMP-binding (E-value: 2.4e-18, bitscore:
                     64.4, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIFENEDGISLENMGKLVYSVSQTSQVYLDCQVMTGSDGLSITWD
                     YAQQLFDPVMMERMFERFTAIIEAAGEGSMLSERESAFVDQYNQTDCDMESITLTEAFE
                     KQVLLRGDHIALVTGEGTYTYQMINDMAEKMAAGLKRRGLRNGDKAAVYEYRNAQTIAA
                     ILAVLKCGGVYVPISPGIPENRKEYILENSGSKLEITADLAEELKQESGCLHKEIETEA
                     DDTAYIIYTSGSTGVPKGGCDHTPGGYEYHFGCKQKV"
     gene            25090..27639
                     /locus_tag="JWH23_RS27200"
     CDS             25090..27639
                     /NRPS_PKS="Domain: AMP-binding (7-250). E-value: 1.5e-49.
                     Score: 160.6. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27200_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (355-419). E-value: 1.3e-16. Score:
                     52.6. Matches aSDomain: nrpspksdomains_JWH23_RS27200_PCP.1"
                     /NRPS_PKS="Domain: NAD_binding_4 (480-721). E-value:
                     1.3e-44. Score: 144.2. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27200_NAD_binding_4.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002: AMP-dependent synthetase and ligase"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF013530.4"
                     /locus_tag="JWH23_RS27200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_277406996.1"
                     /sec_met_domain="AMP-binding (E-value: 2.5e-60, bitscore:
                     202.7, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 1.8e-10, bitscore:
                     39.7, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.3e-42, bitscore:
                     144.2, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTILDVNRRFEITENDRIFGVSSFTFDLSVYDIFGTFAAGAALI
                     LAGDNKNTEELNRLVSEEEVTVWNSVPALFELLLSVRETAEENYFDEINQELEVKFEQT
                     ESLRIVMLSGDYIPVDLPDRIRNRYENARVISLGGATEGSIWSIYYPVNRVEPTWTTIP
                     YGYPLGNQKLYILNDNQKICPIGVPGEIVIGGAGVAQGYCNDPEKTSRSFLETASLGRI
                     YRTGDMGVLTEKGYIDFLGRRDNQVKINGYRVELGEIESAMLRFEGVKRAVGTVSADNR
                     NRLIACFTSDEKIPVERIREFLTDKLPYYMMPALIRQIETIPLTANGKIDRKQLSYMDK
                     LPDERIVLAPETENQKILYQYFKEVLGVDQFSIKDNFFELGGDSMKGISLYNKINEVFE
                     ADMNLIFRYQTVEALAARLIKRKSDYKEERLKQFKQQYVAAADTLDAQKKLAEDYNTYL
                     NNAEKKLKTFKTRGSKDYKAVLLTGGTGYLGANLMETLLTTTDTLIFALVRGDDYINRL
                     KENLIFYFGEAFYSRYRNRIVAFQGDLSQEMLGQKKDGYESLCHTVDAVFHCAGKVEHF
                     GKYEDFYRSNVKSVENLLKFSMEGKQKELCHMSTTRVMESIESNDIEVLFHEDYKGING
                     NAEELYVRSKKEAEDLIEEYRKKGALVKIFRIGTIVFDARNGKFQRNIDFNSFYLIMQA
                     FFELGAMPNVDATLLDFTFVDECSRAIVKLAMEKEVKNGIYHIYNENKLGMYEFYDKLK
                     HAGMKENLEIMEFGQFFDFVYDSYKKESLEDCINTLLLHSSAYMSLEGAMRVIVNDYTR
                     GILESMGFKWSRVSEEHIRGMLEYGKKIGFFKKEVIV"
     aSDomain        25111..25839
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27200_AMP-binding.1"
                     /evalue="1.50E-49"
                     /label="JWH23_RS27200_AMP-binding.1"
                     /locus_tag="JWH23_RS27200"
                     /protein_end="250"
                     /protein_start="7"
                     /score="160.6"
                     /specificity="substrate consensus: Cys"
                     /tool="antismash"
                     /translation="NRRFEITENDRIFGVSSFTFDLSVYDIFGTFAAGAALILAGDNKN
                     TEELNRLVSEEEVTVWNSVPALFELLLSVRETAEENYFDEINQELEVKFEQTESLRIVM
                     LSGDYIPVDLPDRIRNRYENARVISLGGATEGSIWSIYYPVNRVEPTWTTIPYGYPLGN
                     QKLYILNDNQKICPIGVPGEIVIGGAGVAQGYCNDPEKTSRSFLETASLGRIYRTGDMG
                     VLTEKGYIDFLGRRDNQVKIN"
     aSModule        25111..27252
                     /complete
                     /domains="nrpspksdomains_JWH23_RS27200_AMP-binding.1"
                     /domains="nrpspksdomains_JWH23_RS27200_PCP.1"
                     /domains="nrpspksdomains_JWH23_RS27200_NAD_binding_4.1"
                     /locus_tags="JWH23_RS27200"
                     /monomer_pairings="Cys -> Cys"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       25639..25728
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27200_0001"
                     /evalue="4.70E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="JWH23_RS27200"
                     /protein_end="213"
                     /protein_start="183"
                     /score="47.7"
                     /tool="antismash"
                     /translation="PIGVPGEIVIGGAGVAQGYCNDPEKTSRSF"
     CDS_motif       25804..25869
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27200_0002"
                     /evalue="4.20E-12"
                     /label="NRPS-A_a8"
                     /locus_tag="JWH23_RS27200"
                     /protein_end="260"
                     /protein_start="238"
                     /score="37.9"
                     /tool="antismash"
                     /translation="FLGRRDNQVKINGYRVELGEIE"
     aSDomain        26155..26346
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27200_PCP.1"
                     /evalue="1.30E-16"
                     /label="JWH23_RS27200_PCP.1"
                     /locus_tag="JWH23_RS27200"
                     /protein_end="419"
                     /protein_start="355"
                     /score="52.6"
                     /tool="antismash"
                     /translation="KILYQYFKEVLGVDQFSIKDNFFELGGDSMKGISLYNKINEVFEA
                     DMNLIFRYQTVEALAARLI"
     aSDomain        26530..27252
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27200_NAD_binding_4.1"
                     /evalue="1.30E-44"
                     /label="JWH23_RS27200_NAD_binding_4.1"
                     /locus_tag="JWH23_RS27200"
                     /protein_end="721"
                     /protein_start="480"
                     /score="144.2"
                     /tool="antismash"
                     /translation="LTGGTGYLGANLMETLLTTTDTLIFALVRGDDYINRLKENLIFYF
                     GEAFYSRYRNRIVAFQGDLSQEMLGQKKDGYESLCHTVDAVFHCAGKVEHFGKYEDFYR
                     SNVKSVENLLKFSMEGKQKELCHMSTTRVMESIESNDIEVLFHEDYKGINGNAEELYVR
                     SKKEAEDLIEEYRKKGALVKIFRIGTIVFDARNGKFQRNIDFNSFYLIMQAFFELGAMP
                     NVDATLLDFTFVDECSRAI"
     gene            27636..28523
                     /locus_tag="JWH23_RS27205"
     CDS             27636..28523
                     /EC_number="2.1.1.-"
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /NRPS_PKS="Domain: oMT (38-240). E-value: 3.6e-43. Score:
                     139.3. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27205_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF014414.4"
                     /locus_tag="JWH23_RS27205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /protein_id="WP_277406997.1"
                     /transl_table=11
                     /translation="MRLKNFIDHMNAVHSSAKEYYQDMNYDIVPGLNGTNHARWMNVGY
                     WKHAAYYNQACEKLAMLLSRAGKFSESDSVLDVGCGSGEQDFFWSRKYPGISITAMDLL
                     EKHIEEAIVRQKNEEGTSIRFMAGTASRLPFDNESFHKVSALDCAYHFDTREDFFREAH
                     RVLKKGGVLTATDMLPEKQTKKKYFWQKKWREGLFIPEENMYDINCYVKKLKAAGFSQI
                     KVKHIGHEVFTGLAWYFLSRFLMPHKPIEQIKIRIGRVSFFSSFYPKIWGILFGTPDYV
                     LVTAVKNGKEEGTV"
     aSDomain        27750..28355
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27205_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="3.60E-43"
                     /label="JWH23_RS27205_oMT.1"
                     /locus_tag="JWH23_RS27205"
                     /protein_end="240"
                     /protein_start="38"
                     /score="139.3"
                     /tool="antismash"
                     /translation="RWMNVGYWKHAAYYNQACEKLAMLLSRAGKFSESDSVLDVGCGSG
                     EQDFFWSRKYPGISITAMDLLEKHIEEAIVRQKNEEGTSIRFMAGTASRLPFDNESFHK
                     VSALDCAYHFDTREDFFREAHRVLKKGGVLTATDMLPEKQTKKKYFWQKKWREGLFIPE
                     ENMYDINCYVKKLKAAGFSQIKVKHIGHEVFTGLAWYFL"
     gene            28520..29755
                     /locus_tag="JWH23_RS27210"
     CDS             28520..29755
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013316.4"
                     /locus_tag="JWH23_RS27210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="U32 family peptidase"
                     /protein_id="WP_277406998.1"
                     /transl_table=11
                     /translation="MIYSVGTNFDLELLDVIKKYDTKNEIKSVFGKLKIDDFGGGRCSM
                     VLPDVSWKELEQYIAQCHKQDIQFNYLINPMCYGSHEMERDYNKKLDKYLDRLSKIGVD
                     IITTNSPYMLESIRKRFPHFKVTIGLYALVDSLQKVKYWQDLGADEITLNDNFMRNFNK
                     LENLLLVTKGTGLKLRLIANNICLHDCPYSVSHGNSQSHASEKGSSSAGFSVDYCMLKC
                     TMTRLGDPSQFIKSAWIRPEDIVHYEALMEKTGNYDFSIKLLDRTRTTEFLEQVIKAYT
                     QRSYDGNFLDIVNLPSTKAIKNIDMKGVIPKASQFNIQGLMQYKDIFNIPDVYMDNKAL
                     DGFLMKFVNGEFTCGDHVCREVVADSRVECNYCFQWSKKAIRSSNEDIKAWKGKADSIL
                     GQLNSGDFYKLF"
     gene            29772..31133
                     /locus_tag="JWH23_RS27215"
     CDS             29772..31133
                     /NRPS_PKS="Domain: Aminotran_3 (27-381). E-value: 6.4e-91.
                     Score: 296.8. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27215_Aminotran_3.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013: aminotransferase class-III"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012428.4"
                     /locus_tag="JWH23_RS27215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="aspartate aminotransferase family protein"
                     /protein_id="WP_277406999.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.2e-93, bitscore:
                     311.7, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERAYHLWNPFTDLEEFLPYKDVGPMTIVRGEGPFVYNEAGKKFI
                     NASGSLWNVAVGHGREELADIAFEQMKKLCYSSCFRQTHPKACELADCLCALTGNYYDK
                     VYLGSNGSEAVETALKLTRQFFRQSKAEEKRGKYKILSFKGCYHGVSYGAIGLSGDEIN
                     EKLYAPLPGGLLQVEPPYSYHGAYGTKNQAECELKCLEEIQRVIEREGPDTMAAFIAEP
                     VMGERGIITISDSFFDTLMELLDRYDMLMIADEVTTGFGRTGELFATDRWRKRPDILCL
                     GKGISSGYLPVSAVLATKEVYENFKGEDHYFQHGSTSSGNPVCSAVALGNIDIILRENL
                     VENSRKTGEYLMGKIRSLMEERPVLGEVRGRGLMIGMELVKDRVSREPLSESEMFEIVA
                     DCASLGVIVYYNRNVIALFPPLIITKDIADHIYSALKTALDTGQKEEILKRRGY"
     aSDomain        29853..30914
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27215_Aminotran_3.1"
                     /evalue="6.40E-91"
                     /label="JWH23_RS27215_Aminotran_3.1"
                     /locus_tag="JWH23_RS27215"
                     /protein_end="381"
                     /protein_start="27"
                     /score="296.8"
                     /tool="antismash"
                     /translation="IVRGEGPFVYNEAGKKFINASGSLWNVAVGHGREELADIAFEQMK
                     KLCYSSCFRQTHPKACELADCLCALTGNYYDKVYLGSNGSEAVETALKLTRQFFRQSKA
                     EEKRGKYKILSFKGCYHGVSYGAIGLSGDEINEKLYAPLPGGLLQVEPPYSYHGAYGTK
                     NQAECELKCLEEIQRVIEREGPDTMAAFIAEPVMGERGIITISDSFFDTLMELLDRYDM
                     LMIADEVTTGFGRTGELFATDRWRKRPDILCLGKGISSGYLPVSAVLATKEVYENFKGE
                     DHYFQHGSTSSGNPVCSAVALGNIDIILRENLVENSRKTGEYLMGKIRSLMEERPVLGE
                     VRGRGLMIGMELVK"
     gene            31194..31892
                     /locus_tag="JWH23_RS27220"
     CDS             31194..31892
                     /GO_process="GO:0009058 - biosynthetic process [Evidence
                     IEA]"
                     /NRPS_PKS="Domain: Thioesterase (1-224). E-value: 2e-34.
                     Score: 112.0. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27220_Thioesterase.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Thioesterase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004: thioesterase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013166.4"
                     /locus_tag="JWH23_RS27220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioesterase domain-containing protein"
                     /protein_id="WP_277407000.1"
                     /sec_met_domain="Thioesterase (E-value: 7.9e-33, bitscore:
                     113.1, seeds: 16, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLFCIPCAGGSAVMFKKIQDLLLRNVTVRPMELAGRGSRFAEEP
                     YADVSCAVNDLYQKISGWIDQEDYCIMGFSMGGILTFELCRKIGQMGRKLPSGVFFLGV
                     EPPHIKSGTEYYKLDDREFRQAMISIGGIPEEVSQCEELFDLYLPALRADFQLCESYCF
                     TGQIIKFDFNFYLINGLNDSISRCVLDQWAWYCKKCQLDFVPGVHFFINTNTSETCRCI
                     NKGLKEILNC"
     aSDomain        31197..31865
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27220_Thioesterase.1"
                     /evalue="2.00E-34"
                     /label="JWH23_RS27220_Thioesterase.1"
                     /locus_tag="JWH23_RS27220"
                     /protein_end="224"
                     /protein_start="1"
                     /score="112.0"
                     /tool="antismash"
                     /translation="NLFCIPCAGGSAVMFKKIQDLLLRNVTVRPMELAGRGSRFAEEPY
                     ADVSCAVNDLYQKISGWIDQEDYCIMGFSMGGILTFELCRKIGQMGRKLPSGVFFLGVE
                     PPHIKSGTEYYKLDDREFRQAMISIGGIPEEVSQCEELFDLYLPALRADFQLCESYCFT
                     GQIIKFDFNFYLINGLNDSISRCVLDQWAWYCKKCQLDFVPGVHFFINTNTSETCRCIN
                     K"
     CDS_motif       31395..31451
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS27220_0001"
                     /evalue="1.50E-05"
                     /label="NRPS-te1"
                     /locus_tag="JWH23_RS27220"
                     /protein_end="86"
                     /protein_start="67"
                     /score="17.5"
                     /tool="antismash"
                     /translation="DYCIMGFSMGGILTFELCR"
     gene            31935..32618
                     /locus_tag="JWH23_RS27225"
     CDS             31935..32618
                     /GO_function="GO:0000287 - magnesium ion binding [Evidence
                     IEA]"
                     /GO_function="GO:0008897 - holo-[acyl-carrier-protein]
                     synthase activity [Evidence IEA]"
                     /NRPS_PKS="Domain: ACPS (102-165). E-value: 2.2e-12. Score:
                     38.9. Matches aSDomain:
                     nrpspksdomains_JWH23_RS27225_ACPS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012: 4'-phosphopantetheinyl transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013786.4"
                     /locus_tag="JWH23_RS27225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="4'-phosphopantetheinyl transferase superfamily
                     protein"
                     /protein_id="WP_277407001.1"
                     /transl_table=11
                     /translation="MVFVNCMDITECKNELYEKAIHIVSEERRKKSECYHYVDDSKRCI
                     CAGLLLQYGFYHKVGQLSEIEITYNEFGKPFIKNRKEFKYNITHSGKWVAIVYGTTEVG
                     IDVEKIQEGREELVDFCFSEEERLTIYNHIEKEERIKQFTKLWTMKESYIKFLGTGLST
                     GLKSFSVDSTEGLITSNDGKLKKDLRIRSYQFATDYYLSVCSTEDEICIHNVSLKEVVN
                     LLECM"
     aSDomain        32241..32429
                     /aSDomain="ACPS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS27225_ACPS.1"
                     /evalue="2.20E-12"
                     /label="JWH23_RS27225_ACPS.1"
                     /locus_tag="JWH23_RS27225"
                     /protein_end="165"
                     /protein_start="102"
                     /score="38.9"
                     /tool="antismash"
                     /translation="VGIDVEKIQEGREELVDFCFSEEERLTIYNHIEKEERIKQFTKLW
                     TMKESYIKFLGTGLSTGL"
     gene            complement(32760..33456)
                     /locus_tag="JWH23_RS27230"
                     /pseudo=""
     CDS             complement(32760..33456)
                     /GO_function="GO:0008168 - methyltransferase activity
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006774596.1"
                     /locus_tag="JWH23_RS27230"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="class I SAM-dependent methyltransferase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MNVNHYLINHYNNYDEDSRLVPKHGSVEFLTTMKYIEKYIKTGNH
                     VLEIGAGTGRYSHALAQEGYKVDAVELVEHNIEIFKQNTKINENITITQGNAMELSAYP
                     DNEYNITLLLGPLYHLYTKEDKQQALSEAIRVTKPGGIVFAAYVISDGCLLDEGFNRGN
                     INVLQYIEQGLIDSQTFAAKSEPKDLFELVRKEYIDDLMSIFPVTRLHYVAADRFTWCN
                     KSCY"
     gene            complement(33453..33713)
                     /locus_tag="JWH23_RS32905"
     CDS             complement(33453..33713)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS32905"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_349772714.1"
                     /transl_table=11
                     /translation="MTKAIDFYNEIDNEKNVKLFSDTIGVELEQSKIIFLDLFFYAHGI
                     AVLAATKKIAFNRDEAEKMVTNILTAFVRQYKPDWNRGGTI"
     gene            complement(33837..34049)
                     /locus_tag="JWH23_RS32910"
     CDS             complement(33837..34049)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS32910"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_349772715.1"
                     /transl_table=11
                     /translation="MPPKAKITKDMILNIVFDITRDTGYETVNARSISNKLLCSTRPIL
                     LAIKNMDELKTEFFWIFLIDITRNM"
     misc_feature    34130..34139
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(34210..34662)
                     /locus_tag="JWH23_RS27240"
     CDS             complement(34210..34662)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002600587.1"
                     /locus_tag="JWH23_RS27240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="VOC family protein"
                     /protein_id="WP_277407002.1"
                     /transl_table=11
                     /translation="MQYQGTLIAVSDMEKTKQFYETVMEQKVIMDLGVHVSFGGFSLQS
                     NYAELVGADLPGKTQPNNFQLYFEVEDLDYWQNKISSTEGIEFIHKAKEYPWGQRVMRF
                     YDYDKFIVEVSESMASVAKRFLAQGLSVEETAERTMYPVEFVKSLM"
     gene            complement(34698..35534)
                     /locus_tag="JWH23_RS27245"
     CDS             complement(34698..35534)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042696.2"
                     /locus_tag="JWH23_RS27245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_277407003.1"
                     /transl_table=11
                     /translation="MLMKDSIQNYMNNSRVLIRGVDFIYIQPHSELRNFISNYTITFPV
                     IGMMSDNYAVMPHGSATLVLSCTGSHIHGNLFGPITKPSFVGKSANNFSLLFIVEFQPA
                     GYYAFSGMPQKEITDCVIDFEHVNSSMNRLMANELETSLSIQELITKMDRLFLAHLKGA
                     FYRQEFAQASNLIINSGGTFSVKELSQNVFYSERHLGRLFDEYMGVGIKSFSRLVRVNR
                     SIRLLQRHDYNLTQVFMETGFYDMPHFIHDFKAICGITPQEYRDNMSDFYSEIAKF"
     misc_feature    35496..35510
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence:
                     medium, score: 22.0"
                     /tool="antismash"
     gene            35887..36456
                     /locus_tag="JWH23_RS27250"
     CDS             35887..36456
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013495079.1"
                     /locus_tag="JWH23_RS27250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF1801 domain-containing protein"
                     /protein_id="WP_277407004.1"
                     /transl_table=11
                     /translation="MVDAFLEHLEKWRDEHEKLRELCLACQLTEELKWGQPCYTLNNKN
                     VVIIGGFKNYIALTFFKGALLKDKDRLLVQQTESVQAGRQLRFTSVEEISERETMIKAY
                     IEESIEIEKAGLKVPVEKKAEIPIPDELQIKFHDDPAFKNAFYALTPGRQRGYIFYFNG
                     AKMSETRISRIEKYMDKIFHGLGIDD"
     gene            complement(36511..37479)
                     /locus_tag="JWH23_RS27255"
     CDS             complement(36511..37479)
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1287: AraC family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_012721243.1"
                     /locus_tag="JWH23_RS27255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="AraC family transcriptional regulator"
                     /protein_id="WP_277407005.1"
                     /transl_table=11
                     /translation="MNKYDDASWGSMAKKYNLQQTPYGPGTGHYFPPHWSNGWIVEVSP
                     AQGLYVSSAWFSPNQTIVHKIDIKEPCLWLFCIDCGEIIYSQQGKAATTFSPICHKLIN
                     PQKAFQFTFPKNVHTCFTSILIFQDFLEPFLQARANAPKISIEDGKLWETEHLNTPGTM
                     LIFEQIRWAIRNGDMPPFAFEGMVIHLLGSIARNYPVIPDRRNDRRNYVTWENEKKMYA
                     VKQTLDENILDVPSMSELTKIADMSDSKLRLSFKNTYHIPLYDYIRREKMKRAMQLLSS
                     DHLSIHHIAELCGYKNPSKFTAAFQEVHGITPSQFRKTFNL"
     misc_feature    complement(37712..37730)
                     /note="TFBS match to DmdR1, Iron(II)-dependent repressor,
                     confidence: medium, score: 27.73"
                     /tool="antismash"
     gene            37787..39646
                     /locus_tag="JWH23_RS27260"
     CDS             37787..39646
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013648.4"
                     /locus_tag="JWH23_RS27260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_277407006.1"
                     /transl_table=11
                     /translation="MKKRGLLLCSMMLLFVLSGCGKAEIANNKGTDINKIDTVMGEIEV
                     PQKPERVVVNWYIGDAFSLDLNVVGYSAWAQETMPFYDKFSTSAKLENWAAEDIMAVEP
                     DLIITYNTEDFENFNKIAPVLVIPESEVTPAERLRMIGKATGKEKEAEALITTFDENLA
                     AAKAEFQSEMYDGKTFSIMEDWGSTGEWSGVAYETGSRGGTLVYDYLGLKMPEKLEELI
                     AKTGEKRGSLSYEVAHEYFGDYILWFQQEGKESEYAKSDIWKSIPAVLEGRVAEIPGEN
                     LGLFYYDDIASLTAQLDYAINAIKNIEVIIEGEICMLKFKNTGALLLAFAIGISVSGCG
                     SKPVKSAAEGSAEIRVINTEQGEIEIPADPKRIIVTYCVGDALALGVKPVATNDAAGTA
                     YEKELDGVPVWDEFEAEQLISYEPDLIIVANQKQYDIASKIAPTILLPFTTQSMDERVR
                     FMGDVLNRQEKANAVLDEFHQKLEGAKASLREKNVLDKTFSVIESDGNGGIWVYGDKWG
                     RGGDLLYSQLELQAPEIIKKEIIAAEQHRDVSMEVINDYIGDYIIIARGLEELKGNTIW
                     ESLPAVKAGNVIPIDFTLFYDIDIYSSNVQLDYLLNALLKTQE"
     gene            39678..40703
                     /locus_tag="JWH23_RS27265"
     CDS             39678..40703
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003362764.1"
                     /locus_tag="JWH23_RS27265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_277407007.1"
                     /transl_table=11
                     /translation="MKNTTTKGWKGSINFAFYMALGFGILLIVSAASITFGAADMRIAT
                     AWEAVFQFNPELTEHQIIQTLRLPRTVADLMVGCSLAICGAIMQGTTRNPLADSGLMGI
                     SSGSTFAMALCMAFLPMRTYGQTMLFACMGAAVTTAMTYFIASMGKGGMTPQRLVLAGI
                     SISMLFGAFSQYISIRYHLGHALAYWTAGGTAGAKWSELLTVFPAFVFGVVGAIALSPS
                     VTVLSLGEDVATGLGLKTRFVKGISTIIVLLLTGLSVIIVGPVGFVGLITPHIVRYFVG
                     VDYRYIIPASGLYGALLTVFADLAGRLINKPYETPIGIIFAVIGVPYFLYLARKQRREF
                     E"
     gene            40700..41272
                     /locus_tag="JWH23_RS27270"
     CDS             40700..41272
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013219.4"
                     /locus_tag="JWH23_RS27270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_277407008.1"
                     /transl_table=11
                     /translation="MKKKGFILLFMTVLMVLVAIISINSGKMNLTPAEVMSVILGKGTP
                     KQNLIIMDFRLPRIILAVCVGIGMGISGCIMQSLLRNDMASPGTLGISSGSGLFVLIFV
                     VIFSAKSNSSAILMPVLSFVGGMTAAGLIFLLSYRKNKDISPHRIDFNGCSAGKRLWCA
                     NYTAYSETGPKSDGIYTALECRQFVGR"
     gene            41166..41696
                     /locus_tag="JWH23_RS27275"
     CDS             41166..41696
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /GO_process="GO:0006826 - iron ion transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1011: transport
                     system permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013219.4"
                     /locus_tag="JWH23_RS27275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="iron ABC transporter permease"
                     /protein_id="WP_277409991.1"
                     /transl_table=11
                     /translation="MGSGYGALTTLLTLKLDQNQMEFIQRWSAGSLWGDDWRYLGILVP
                     WTAILCAYALYKSHVLNILNLGNETATGLGTAVKPEFIGLTVAAVALSSGSVSLGGNFF
                     FVGMIAPHMARKIVGSNHKLLLPAAGLCGAIIVLLADTITRTISLGTDVPTGIVITVLS
                     TPYFLYLLAKANN"
     gene            41707..42528
                     /locus_tag="JWH23_RS27280"
     CDS             41707..42528
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003399183.1"
                     /locus_tag="JWH23_RS27280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_277407009.1"
                     /transl_table=11
                     /translation="MNSIATENLDIAYDNALIVENLEMAIPRNKITSIIGPNGCGKSTV
                     LKAVGRILKPKKGMVYLNGGDISTLPTKEIAKKMSILPQTPSAPGGLTVSELVAYGRFP
                     HQNGFGKLTKEDKKIVEWAISATKLSDLEHREVNTLSGGQRQRVWIAMALAQQTDLILL
                     DEPTTYLDMAHQLEVLELLYSLNRNQGCTIAMVLHDLNLAARFSDYMIAIRSGKIIQHG
                     SPKEVMIPEVLKKTFSIDAEVVHESRTGRPVCLTYSLLHQEDLPKREAISL"
     gene            42525..44246
                     /locus_tag="JWH23_RS27285"
     CDS             42525..44246
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="resistance (resist) ABC_efflux"
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011948104.1"
                     /locus_tag="JWH23_RS27285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_277407010.1"
                     /transl_table=11
                     /translation="MNIALRIFCEAKKYRIFLVFAFLALVVSTVAGFYTPWALRELTSL
                     ATEGSGDFGSEALRIGLLLLGAATLQAAGASAAGYMNHYAALHYVADLRKMLYGKLQNM
                     SLSYFHKSRTGDLTSRVVNDTLDAEVLLAHVIPDFIVNILTFIGVGILLFTINVKLAFM
                     SLVAIPFLLGITLWQGHHVSPVWKENSRVRGALAGKVQDNLSGMKEIQIFNQQSHEENS
                     IAHLAMLHSRAYLRASFFFETSYPLLAFVTALGTVIVVIYGGRLVGTGEVNIGDIVGFA
                     MYLSMFYGPVKNFSALVERAGEAGAGCKRVFDVFDEISEVKEKENAIVLKRVNGEIELR
                     DLTFSYHEDIPVMENINLKIQTGQTVALVGTTGVGKSTIANLINRFYDPQNGAVYIDGI
                     DIRDVTLSSLRNNISMVLQDTFLFNGTVYENIAYGWKGATKEDVLAAAKAANAHDFIEK
                     MEHGYDTTIGERGVLLSGGQRQRIAIARAILRDSPILILDEATSALDTKTEMEIQAALN
                     EISKTRTTIMIAHRLSTTRDADLIVVLDGTGIAEIGSHDELMKRGGIFAGLHGVHA"
     gene            44295..45230
                     /locus_tag="JWH23_RS27290"
     CDS             44295..45230
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013648.4"
                     /locus_tag="JWH23_RS27290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_277407011.1"
                     /transl_table=11
                     /translation="MAVSFMILLLLSGCSADLKDSDQADKSSTESTDTRLFSTDKGEIE
                     IPVHPKRVISDFGLLGDVLALGVMPVAIEDYGATDVAFKDLIKDTKVLEKWEPEYLMAE
                     NPDLIITRNEDSYEQLSKIAPTVYIPVYELETGERLSFLSDALGLGQEKGREVVDNYET
                     KVKEAKDKLKNTGLYNKTFSIIRVQGENEIGVRWSNNLGGQILFGALGLPQTEAALREV
                     KAGVDWGATLSFEAVTEYMGDYILVTEYGNYQLIENNPVWKSLSAVQNGNIIVLSEPYM
                     YLNDIYSWSAQLDLVTGELLNLAEKNGVQK"
     gene            45267..46202
                     /locus_tag="JWH23_RS27295"
     CDS             45267..46202
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1033: iron
                     compound ABC transporter, periplasmic"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF013648.4"
                     /locus_tag="JWH23_RS27295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter substrate-binding protein"
                     /protein_id="WP_277407012.1"
                     /transl_table=11
                     /translation="MFRQIKKKTIFILALSMIFVLSGCSNSAKTEETSNEESVRRESDS
                     TKSKIIHMDYGDVEIPENPQNVIVTFNQGDVIALGIIPVGATFSEGSAFEELAENITQI
                     DGWEINPEELLSLKPDLIIWGSYDEKSYETLSKIAPTLAGDFYSMSYEERLRFFGEIFN
                     CEEKAEVLIQGFNSKLKETQAKLDNAGLLNKNIACIEVIGDTVRAYQFGRGGSLVYNML
                     GLSAPEKLNEAFKDKTSIDISYEVLPEYMGDYILLNTGKDKLVDNKVWENISAVKEGRL
                     IQASSNMFWFNDILSLSKQIDIIANSMLEK"
     gene            complement(46271..46510)
                     /locus_tag="JWH23_RS27300"
     CDS             complement(46271..46510)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS27300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277407013.1"
                     /transl_table=11
                     /translation="MNHDKLIAQVKDEYARIASSESQQHFHQTTTEVTPEAYYEKLLSK
                     VINEIDKGTFDNFKSGEEVVTAVANDKTWLSDWK"
     gene            46727..47362
                     /locus_tag="JWH23_RS27305"
     CDS             46727..47362
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1057: TetR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006772395.1"
                     /locus_tag="JWH23_RS27305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TetR/AcrR family transcriptional regulator"
                     /protein_id="WP_277407014.1"
                     /transl_table=11
                     /translation="MRVIKDADQRKNEILDAAETLFTLKGFDKTSTNEILEAVGIARGT
                     LYYHFKSKEDIMDALIERHTSRLLKAAKEIAEDKGKPVYDRIIQSVRALKINQSGNEVL
                     EHIHRPQNALMHQKVQKTILNGLPPILTGIIREGIEDNLFHTPYPYECVEMLVVYASTV
                     FDGDMLDINQQEYASRAQAFIFNVERLLGVESGTLSFASQIFEEETEG"
ORIGIN
        1 acgttccaca tggaagagcc aatgcaattt tacttccatg ggtgttgggt tacaatgcag
       61 ccgatcagag agcaagaaaa cgatatggga ttcttgcatg gaggcttgga ctttctccta
      121 aaaatgctga aaacggagct gaagtgctgc aggcagcagt aagaatactg tccgaagcga
      181 ttaaaattcc tgcttcgttc agagaagcag gtgtcaatga gacagatttt tatgataatc
      241 tggatcggat gacaatggct gcatcaggag ataactgcac gaagacaaat cccctccagc
      301 cattagcaga ggatttaaag gatttataca aaaaaagcta tacaggagga aaataagggg
      361 atgaaggaaa aaatactgat tccatgtttg gcagagttcc tgggcacatt cttatttgtt
      421 tcaattggat ttgcctctgt agcggccatg gtactgaaga tgagtgatat aagttatcct
      481 tttatggcag tatgctgggg cggggcgatt accattgcga tttatattgt gggaggtgtg
      541 agcggcgctc atttaaaccc tgcagttaca gcagcattgg ttgtatggga tggatttgac
      601 aagaaaaagg ccatatgtta tatcgccgca cagacactcg gtgcattctg tgcagcagca
      661 cttgtatact atctgttttc ttccggaata agaggaatgg aagaagcaaa cggatgggta
      721 agaggaaccg cagaaggaac cggagcgatg ggaatctttg tgactggagc ggcagccggg
      781 gtctccatgt tgaaagcgtt tatcaatgaa acagtcatta ctgccatgct ggtacttacc
      841 atatatgcag tgacagacaa agaaaatgtt tcagcacccg acccgggaat cggagacatt
      901 gccattggtg ccatcgttat tttctgtgga attgcctttg gcccactgac cggattcgcc
      961 atgaatcccg ccagagattt tggtccaaga ttatttgtga tggcagcagg ctggggaaaa
     1021 tacgggttag gcagtaattt gtatggacta attgttccgg ttttcggacc ttttctcgga
     1081 ggtattttag gtggtggtat ttataaaaaa atgattaaac ccttgagaga aaaaatgtaa
     1141 tgtagatgga ggaaaaacca tgaagcagat attaaatatt gggccggagg aaacaagccc
     1201 aaggattcaa aacttaattg atggattata taaggcattg ccggcagtgg aatcagagag
     1261 ggctttactg attacaaaat cttataaaga gacagaagca ttgccaatgg ttcttagaag
     1321 agcaaaggct ctggaatata ttctggaaaa tatgaccctg gtaatccgtg acagtgaatt
     1381 aattgtaggt aatcttacga ctgcacccag atccacccag attttcccgg agttttccaa
     1441 caaatggctt ttggatgagt ttgattcact tgcacagcgt aagggtgatg ttttttacca
     1501 ttacagatga agtgaaaaat cagttaaaag agtgctttac atactggaat ggtcgtacag
     1561 tcaatgaact ggcaacagaa ttaatgtatg atgatacaaa aacggctatg aatcataatg
     1621 tattcactgt tggaaattac tattttaatg gcgtgggtca tatcagtgtt gattatgaaa
     1681 gggttttaaa gaatggcttt tcaggcatca tcaaagatgc ggagaatgca ttggcgaacc
     1741 tggataaagg ttgtcctgac tcgattgaaa agacccattt cttaaatgcg gtaatcatta
     1801 catcaaaagc agcgattcgt tattctgaac gttttgcagt tctggctgaa aagatggcag
     1861 cagaagaaag agatatgaag cgggcacagg aattgagagt gattgctgca aactgcagga
     1921 aagtccctgc taatccggcg gagaattttt atgaggcttt acaatccttc tggtttgttc
     1981 aggcaatcat acagattgaa tccaatggcc attccatttc cccccatgcg ttttgaccag
     2041 tatatgtatt cctattataa ggcagatatg gaaagtctga atttgtcaaa ggaaagagcg
     2101 caggaacttt tggactgcct gtgggtgaag tttaatgatg tgaacaaagt ccgtgatacc
     2161 ggatccacca aaggctttgg cggctatccc atgttccaga acctgattgt aggaggacag
     2221 gatagagcgg gtatggatgc gacaaatgaa ttgtcgattg catgcctgga agcaacccag
     2281 catacaaagc ttccccagcc atctatttca attcgtgtgt ggaatggttc tcctcatgaa
     2341 ctgttaatca aggctgctga aacttcaaga ctgggccttg gtatgcctgc atattacaat
     2401 gatgaggtaa tcattccggc attggtaaac agaggactta ctctgggtga tgcgagagat
     2461 tatggaatca ttggctgcgt agaacctcag gtaggtggaa agacggaagg ctggcatgat
     2521 gcagcattct ttaatctggc aaaggttctg gaactggtgg tttacaacgg ctgtctggat
     2581 ggagtgagaa ttacgcctca aaccggagaa tttacttcct ttaccagctt tggacagatt
     2641 ctggaagctt atcagaaaca gatggaatac tgtgtaagat tcctcaccaa tgcagataat
     2701 tccgttgata tggcccatgg tcagagagct ccccttccct ttgtatcatc tatggtagat
     2761 gactgcattg gaaaaggtaa gtcgattcag tgcggtggag cccattataa ctttaccgga
     2821 cctcagggcg ttggcgttgc aaatgtgggc gattctctga tgtgcatcaa ggaacttgta
     2881 tttgataaga aaaagtatac cctcgctcag atcaaacagg ctatggagga taactttggc
     2941 ggaacatcgg tagaagccgt ggatgcagag atattaaagg aagtagtacg tcgtctgaca
     3001 gaaggaggaa agagcctgtc tccagatcag attgcccgcc ttgcagaact tacatcccag
     3061 ggaataacag caaagaaagc ttctggtgat tacagcagta tgctggagga tatggaaaat
     3121 gtgccgaagt tcggaaatga tattgaagaa gccgatgacc tggcaagact ttctgcactg
     3181 gtatattgcc gtgaggtaga aaaatacaga aatgtcagag gaggacaatt ccagccagga
     3241 ttatatcccg tatctgcgaa tgtacccatg ggtgaacaga ctggtgcaat gcctgatgga
     3301 agaaaggcag gagagccttt ggctgacggt gtatcaccgg tatccggcag agacaccaat
     3361 ggaccgacag cagctgctaa ttccgttgca catctagacc atatgattgt atcaaacggt
     3421 acattattta atcagaaatt ccatccttct gctcttagcg gaagagaagg tctggaaaaa
     3481 ctttctgctt tggtacgagg attttttgat aaaaaaggaa tgcatgtaca gtataacgta
     3541 gtaggccgtg agacactggt tgatgcacaa aatcatccgg atcagtataa gaatctggtt
     3601 gtccgtgtgg ctggctacag cgctcatttc atttaccttg ataagagcct tcaggatgat
     3661 atcattaatc gtacagagca aatattttag gagagtgaga aacggaacat gcagggaata
     3721 tatgatgcga aaggaattgt ttcggaaatt cagagatttt ccgttcacga cggaccaggt
     3781 atcagaactc tcgttttcct gaagggatgc ccattgcgct gtaaatggtg ctgcaatccg
     3841 gagaatctgt ccagagaacc ccaatatatg ctggttcagg gaaaacagaa gctgattgga
     3901 aaggaaatga cggtagaaga agtgatgagg gagatcagga aagacatgat ctactattac
     3961 cgttcccatg gtggtttaac aatctctgga ggggaagttt taatgcagcc gctctttgcc
     4021 aggtctttac ttgaggcatg caagtctgaa ggtatttcca ctgccattga aacctccgca
     4081 tttgcggaat atgaagtgat tgaacagctt cttccctggc ttgatgtggc gctgtgtgat
     4141 ataaaacatg tggatgagga aaagcacctg aagtttacag ggctgtcaaa cagagggata
     4201 ctggaaaaca tcaggaagat tggtctgtca aaaacagaac tgatcgttcg tgtaccggtt
     4261 gttcccggat tcaataatac agaaaaggag attgaaatga tctccaccta cgctgcctct
     4321 attcagggtg taaagcgact tcatcttctg ccatatcacc gtttgggaga ggcaaaatat
     4381 gaagggctgg gagaagacta ttccttaaag ggaatagaac ccatgaacag tgaacagatg
     4441 gaacggttgc tgaagattgc cagaatgtca ggtctggaat gccagatcgg cggataagag
     4501 agattggata tgacatccct tatcattaca attctgtata cgactttaaa agtcagcttt
     4561 tcgctatgag cgaaatgctg gcttttttac ataaagtcaa tatcttgcgt cttttttaaa
     4621 acagttagat ttaataaggg caaaaattcc gacccctccg cctatgagaa gcacttcaat
     4681 tgcgcccatc caatgcagag tgatgttacc gttcgttgtt gtaactgcat aaataaggtg
     4741 gtgtcctccc aataaaatac aaagtacaac cgaaataagg gagagtattt ttgcatattc
     4801 aatgttacgc ctgatcagcg taataacaat gcccatatca atcccgacat tccacaaagc
     4861 gatttcggcc tgccatcccc gactcatcct ccataccgaa aaagtttctg ccacattggg
     4921 aaaaaacatt tgccatacaa atgcaccaat tgtcatcaac aagaataaaa gcaaataaag
     4981 atacaaatat ttttctttcc tcatttttgt tacctcttct gtgatattcg cagtttctta
     5041 tttttcagag ttaatcacaa taaaacgctt cgattgcctg tgcaaaaaac tctgctgcac
     5101 cttccccata ttcctcattg attgcctgct gacactgcct gttacggtag gactgggcaa
     5161 ccgccagcat caagccctct tcttctttca tctggcaaac ctgtttcatg acgaaaccgt
     5221 attcacctat aattgctttc acttcaaaag aattgagatc agaaccacgt ttttctatta
     5281 gctttttacg tattgtgtcc tcccgttttt tatagctttc agcaacttct ttgctgatgg
     5341 ggttttcaag tgtggataaa taagcatcct tcccgccata ccactcaacc actttggcat
     5401 agcgcttttg catatcttct gaggatactg cttcaatata atgcttcttc cagtgctcta
     5461 agctgccaaa ttcaccaatg gctgtctgac gcatttcctc cggcatgctg ttaaacataa
     5521 gctgaaacat tttctcgatc tctgttttgg tgaaaactga aaaatccatt ttgttgtctc
     5581 ctttcagaac cttatctatg ctggcaatca ggcgttccat gcgttctttt ttttcaacca
     5641 gcatctctct ttgcatttgc agaatctgat ttctatcaag tgacgggttt tccaagatgg
     5701 ttttgatatc ttttaaaggt atacagaact cacgaaagaa taaaatctgt tgtagaattt
     5761 ctaaggctct gtcatcataa agccgatatc cagcttcact tttatctgta ggcggaaaca
     5821 aaccaatttc atcataatag tgaagcgtgc gagtactgac accagtaagc tctgatactt
     5881 cctttacagt tctcatacta tctgtcctcc tgttcttgat aggataacta tactccataa
     5941 cgttccgtca gagtcaatca ttttttaaat ttatttgtat tttatatgta tataagacag
     6001 tataaacagg aaatctatcc cttgtaagac agggagcgtc tacataaagc caaaaggaga
     6061 tctgtttatg gaaagcaaat gtgatacaca ggagaaattt aaggacctgc agaaatttat
     6121 tgacagcatg gaagacagga gaggagcgtt aattgcagta ctgcataaag ctcagcatct
     6181 ctatgggtat ttatccaatg atgtgatttt tttattgctg aaaaacttga gatccccagt
     6241 gcgaaagtgt ttggtgtcat tagcttttac tcttacttta ccacagagcc aagaggtaag
     6301 tatgtgatca atgtatgcct gggaaccgcg tgctttgtaa gaggtgccga tgccattatg
     6361 cgggaatttg aaaagatcct gaatatcaag gcaggtgaaa caacggaaga taaaaaattc
     6421 acgttatccg gattacgatg cattggggcc tgtggacttg ctcccgttgt gatggtcaat
     6481 gataaggtat atggaagggt tgagctgaat caggttaaag caatcattga agaatatcag
     6541 gaggaagcgt gatggctaag ttaaaaacag tagaagaact gaaaaagatc agacaggcag
     6601 ctcttgatca attagactta cggtctaccg ctgaatccga ggataagatt ttagtacggg
     6661 tgggaatggc gacctgcggg attgcaagcg gtgcaagaac aaccatgaaa gcaattctgg
     6721 atgaaattgc aaagcagggg cttgccaatg tttccgtgac acagactggc tgtatcggat
     6781 attgtgctca ggaaccggtg gtcgaagtta tctccaaagg aatgccgtct gtcctgtatg
     6841 gaaaagtaga cgagaacaga ggacgggaaa ttgtgattga gcatataaaa aatggccgcc
     6901 ttctccaaaa tgcaattata aataaatcat ttgaaaatat ggaataagga ggagggcata
     6961 tgagtaactt cagaatgcat ttactggtct gcggaggtac cggctgtacg gcgtccgata
     7021 gcctgaaact ggtgaaaatg ctaaaggaat caataaaaaa acatgaaata accaatgagg
     7081 tggaagtagt ggttaccgga tgctttggct tttgtgagaa aggtcccatc ttaaaagttt
     7141 atccggataa tgtcttttat atcacggtaa agccggagga tgcagaggaa atcattacgg
     7201 agcatgtgat aaaaggccgt aaggtggaac gtcttctgta tgtggaacca aatactaaaa
     7261 aacgattaga gggacaaaaa tccattccct tctataaaaa gcaaatccgg atcgcactta
     7321 ggaattgtgg ttttattaac ccggaagata ttaatgaata cattgcggca gatgggtatc
     7381 aggcattggc aaaatgccta acggaaatga gtccggagga agtaattgac acagtcgttc
     7441 agtcaggtct cagaggaaga ggcggcggcg gttaccccac cggccttaaa tggaaatata
     7501 caagacagag tcagtcggat gaaaaatata ttatatgcaa tgcagatgaa ggagatccag
     7561 gtgcatttat ggacaggtcc atattagaag gagatcccca ctctgttctt gaagcaatgg
     7621 caattgcagg ctatgccata ggagcccagt atggatatat ttatatcaga gcggaatatc
     7681 ccctggccat aaaccgtctt gaaatagcca ttaagcaggc aaggaaactg gggcttttgg
     7741 gagaggatat tttttccaca ggatttaatt ttgatatcgg gttacggtac ggcgccggtg
     7801 catttgtctg cggagaagaa actgctctca tccattccgt cgaaggtaaa cgaggggagc
     7861 ccagttcaaa acccccgttt ccggctcaaa gaggtgtctg ggataaaccc tcctgtgtga
     7921 ataatgtaga gacatttgcc aatattcctc cgattttttt aaagggacct gcctggttta
     7981 aaagtattgg tacggagaaa tcacctggta caaaagtgtt tgctctggcc ggtaaagtaa
     8041 ataatgtggg ccttgtggaa gtaccaatgg gcattacctt acgtgaggtc atctatgata
     8101 tcggtggagg aataaagaat aacaagaagt ttaaagctgt gcagaccggt ggaccttccg
     8161 gtggctgcat caccaaagaa aatttagata tccccattga ctatgagtca ctgaacagta
     8221 ttggttctat gatgggatct ggcggaatga tcgtcatgga tgaggataac tgcatggtgg
     8281 acattgctaa gttctacctt gagtttacca aggatgagtc ttgcggaaag tgtacgccct
     8341 gccggattgg aaatacaaga atgctggaga tacttgaaaa gataacaaag ggaaatggta
     8401 cggaacagga tttaaaagat ctggttgagc taggcgatgt gattaaagat acatcccttt
     8461 gcggacttgg acaaacttcc cccaatcctg tactcagtac cctgcattat tttgaggatg
     8521 agtatctggc tcatgtaaag gataaacact gtcctgccgg agtttgtcag gcactttttt
     8581 cctttcatat tttaccggat aagtgcgtgg gctgtaccgc gtgtgcaaga atctgcccgg
     8641 ctcattgcat cgaaggagaa cgtaagatcg ttcatgtgat tgatcagtca agatgtatca
     8701 aatgcagtgc atgttataat acatgtaaat tcaatgccat agaaaaaggg taagggagga
     8761 ggaacttatg ggtctggttc atgttacgat taataatcaa acgattgcag tggaggaagg
     8821 cacaacgatt ctggaggctg caaagaaact ggatattcgg atacccacac tctgttacct
     8881 taatctggaa catgtaaaaa cggtgaatgg ctctgcttcc tgccgggtct gtgtggtgga
     8941 aatcgaggga aggagaaatc tggctccctc ctgtgcgact cccgtatcag agggcatggt
     9001 ggtaagaaca aacactttaa gatgtattaa ggcaagaaga ctggtagtgg aactattatt
     9061 gtccaatcat cccacagatt gtctgatctg tgaaaagaat ttaaactgtg aattacagtc
     9121 actggcagca gaactggata tacgcagaat caagtttcat ggagcaaggg caactcatga
     9181 aaaggatatc tcaagtaagg caatgatccg aaatatggat aagtgtattt tatgcagaag
     9241 atgtgagaca atgtgtaatc aggtacagac ggtccatgta tattcagccg ttaaccgggg
     9301 atttgatacg tttatcgcac cagcacttaa tttacctatg gataaatcca tctgtacctt
     9361 ttgtgggcag tgcgtttccg tatgtcccac agctgcatta actgttgtaa atgacatccc
     9421 caatgtctgg gaagcgttga atgcaaaaga taaatttgtg attgttcaga cggcgcctgc
     9481 ggtgcgggtg gctcttgggg aaaaattcgg tgcagagcca gggactgtgg ttacgggaaa
     9541 aatggtagcg gctctcagaa tgatgggatt tgataaagtt ttcgacacag atttcgccgc
     9601 agatcttacg attatggaag aagcagcgga attcattcac aggctgcagc atgggggcag
     9661 gcttcccata ctcacaagct gctgtccagg ctgggttaag ttttttgagc atcagttcaa
     9721 tgatctgctt gatattccgt caacctgcaa gtccccccat gagatgtttg gagtgatcgc
     9781 gaaaacatac tatgcagaaa agatggggat tgatccaaaa aatatttttg tggtttccat
     9841 aatgccctgc ctggcaaaaa agtatgaagc tgccagacca gagcttatgc atgatgatat
     9901 gcaggatgtg gatgcggtat taactacaag agaattaggg gatatgttaa aagaagccaa
     9961 tatcgacctg atgaatttaa aggatgaaga atttgatgaa ccattgggag aatctactgg
    10021 tgcatctgtt atttttggaa caaccggcgg tgttatcgag gcagccttgc ggaccacata
    10081 cgaatggctt accaatgaaa ctcttgagga ggtggagttt catgaactca ggggcttcga
    10141 gggaatcagg gaagctgtgg taaaaatcaa tgaccaggat atcaatattg ctgttgccca
    10201 tggactggga aatgcaagaa agcttctgga agatataaga gccggtaaat cccattacca
    10261 tgcgattgag atcatggctt gccctggagg ctgtatcgga ggcggaggcc agccttatca
    10321 ttttggaaac tttgatgttc tgaaaaaacg aatggaagga atatacaaag aagataaaag
    10381 caaaaaatat agaaaatccc atgaaaatcc ggcaattaaa aagctctatg aggaatatct
    10441 gggtgaaccc aatggagaaa aggcacatga acttctccat acctattatg tgaaacgaga
    10501 gaacaggtaa atcagtgaat ccgtaagcca cagacgtaaa tgtttgtggc ttacatacat
    10561 taatcagatg ttaatttgaa ccataacatt atcaatttgc attaattgtc caatgatttt
    10621 gccgatacta tatagtagat gaattatttt ttgtttccag aaaaaagagg aaaggaagtg
    10681 atgggtcatg actaatttta atgttagcag aagttctgga gttcagtaca aatcattttc
    10741 cccgacatca aaagccagtg ctccggattg ggaaagaata ccccataaag ggatggaacg
    10801 tccatcagaa gctgagttta atgccaagat cgatgaattg gcaaaggggc tggcagaagc
    10861 acgtctgcaa aatgacagca ttcaatacga gaatctgagc ctggaaggag ataagttgag
    10921 ggcgcagtat atatcagctg tgtcaccaga cagaaagagc atggtgaaag atgctgcaga
    10981 aataatgaaa caggcaaagg caggaagaac agacccggaa gcgtcaatga atctaattga
    11041 ttacataaat aaaaaggacg gtatagaggt ggttctttct ggttcagatt tacaaccaga
    11101 tacatttgag ataaaggaaa gtaagatggg acaggcagta atggggtatg cctcggggaa
    11161 ctggcattat gcaaatacac cccaggagca agccatgcag caaacttttc tctctcgtct
    11221 taataagacc gaggatcgat attacagaca atatgtgaat ggagatatac aggaagtatc
    11281 aagtcataaa aacatagatt ataccgtata gtatctaact aagaaacagg gacttgctca
    11341 tgagcaaatc ccgtttttta atattatatc ttttttgtta atagaattac cttgccagtg
    11401 tcgccgtaaa cgtaaacctc atccccatcc tccagcacgt cggtagcatt tccaattcca
    11461 agcactgcag gaatgttata ttctctggca acaattgcgc tatgggacag aggaccgcct
    11521 gtatccgaga taaccgccga agcaagaaca aacaggggag tccaggaagg atctgtatag
    11581 cggcagagca gtatgtcacc ggactgcatt ttatcaaact cctgttgagt cagtattttc
    11641 cgtacccggc cccggcatcg tccaccattc ccggaaacac cagacagagt attctggtga
    11701 cccgcttttg tgccaatgga aaagccagac caaagtactt catttttatg acggttgttt
    11761 tttctcacag aaatcaattc tttaagatct gctatgttac ccggtaattc atagacctca
    11821 tctaaggtga gatatcggat atcttccgcc tgttcaaaca actgggggaa acgcttcgcc
    11881 agttcaaatg cagccctgcg ggcaaggccg tagcacattt ctatcatata aaggctttct
    11941 tcccgattca cgtgataggc tcttatttct tcaattttgg tttttaaccg gtctgctttc
    12001 tttttactaa acgtagttgt gatttttgtc attatgtttt gaaatttgac aggtgagtca
    12061 tcgtttctgc cggagctttg cagcaccttc agcatggaaa acagggaatc caaattttca
    12121 aaccaggatt cggagccaaa tgcgcagtag ctgctgcttg atttccagcc gaattcattt
    12181 aagaaacttt gtagttttgc tttaaaatca ggctgattct ccagaaaatc ctgaattgcc
    12241 tggggattgg ttctgtccag ttccataaat aactgttcca gccctggggt gctttgaatg
    12301 taagcggata gtttttttag tttcaggtta agatcccacg ttttataaga aagattactc
    12361 agcaaatcat attcgctcat atttttgtca atttttttta ggtcatgaag aattaatttt
    12421 gatatcccca cagatgggaa aatgttgtaa cggaaacggg tgtaagcaag ctccttagac
    12481 aattccatca gttccatgat ctgccggatc aatgctttga ctggtaatgc agaaagatcc
    12541 gctctctctt ttgagaacaa ttccttcctt atattatgga aagaatcgtt tgttctggct
    12601 gaattgattg aatagttatt aaaactgctc agcaggaacg gaatttttaa caccttaggt
    12661 gagatatgta tttttcccgc agacagggaa agcaatccat tatcagccat ggtcagctca
    12721 ctttccacgg aaatgcccag ttcatgaaat actttatttt tggcttcatc cactatcagg
    12781 catggtttca catcaagggg atagagtggg ttggggcagt gttcgatcca gttgtttaat
    12841 acggctcgct gagattttgt aagctggata tcagtgctgt ttttacgttc agcgtggtga
    12901 ttggacgtgc ctgcaacaaa tataacctgt tctgggagat ggcccattcc atatcctgtg
    12961 ggcactgaaa gtgctgctct gtttttcttc ccagttcaaa tatttcaatt gcctgtttat
    13021 ccgttaaact aaattccctc cgctgctgtg aagatgtttc tctttcttcg gttccttctg
    13081 cactgtagca gaccataatc tttttatcgc ctaatcgttt ctcaacgatc tgcctgtgat
    13141 ttctgtcgta cacatagatg tcaggagtca ctttcccgga tacaatggat tcgcccagtc
    13201 cccatgaggc attgagcatc atcctgcttt tatttttact aatagggtca attgtaaaaa
    13261 ggacacccga tatctcactg ttcaccatac gctgaaccac taccgataac gaaatctttc
    13321 ctgtatcgaa gttcgtctgc ttccggtagg ctgttgcccg tgatgagaag agtgatgcga
    13381 aacattttct gacggaaaga taaagctgat ccagtccctc tatgttaaga taagtttcct
    13441 gctgtccggc aaagcttgct tccggcaggt cctctgctgt tgcagaggaa cgtacggcaa
    13501 cttttgaatt ggccccccaa agcatgatag tagtctgcaa tttcatcctc cagttccttc
    13561 caaagctgac cttttgcaac ttcctcactg gtaagggtgt cacctgatga ggcagaatta
    13621 aatccattgc gtttcatata ctcatcaaaa gcatggctgg taatgctaaa cccttccgga
    13681 actggaaaac cggcgttaaa caattcaccc agattcgcac ctttaccgcc agcagctaag
    13741 atgtcttcct ttcttatttc actgaatttc ataacatatt tcatagataa ggcctcctct
    13801 ttttttaacg tcttgccggg tttatattta aatgccagaa gaatggatgc agtacctgac
    13861 agggcaatta tagtgattcc tgcgataaaa taattttcgg gaaaatgaag tgtaaattga
    13921 aataatatgg ctcccaggct gccgcctaaa ttgcgtatga gatgagccat actgttaact
    13981 cctgcagcat ggtgaaccgt cctgtttgcg gcatatccta aaagtgcaga catcaggata
    14041 ccggaaccaa gtccaagtgc tgtaagggca aatacaataa atgatttcat caaaagactt
    14101 cctgcaaggc aggtgatcca gccaatagcg atcatttccc gctctttatg ctttgccgct
    14161 ccgccagcaa cgctgccaat tcccatggca aaaacaaata cagttaaaag agtaccggac
    14221 cggtcaggat tcatatgaag ggtaaactgc ataatgccag ggagataagc cagacagatg
    14281 ttatagaatg ctcccagaag aaaaatctgc aggcagagat tgcggagcag ggaatcactt
    14341 aaaaattcct ttggaagtat ggcattatct ttttgtgtgt cttttattac aacaagaaat
    14401 aacagcgcca tgcctgcaag aagcaggaaa tactggctgc ggtaagcaaa ttcaatacct
    14461 aaggtcagaa gcagaattgc tgtaatcatc aaaatgtgtc gctgcagctt taagggggat
    14521 ttagtaagcg gatctgcttt ggcagaaatg tttcgaaaca caagtaaaaa gcttataatt
    14581 tcaatgggga gtaaaattat aaaaatagtc tgccaggttg ccagttgcgg aagatatccg
    14641 cctgcaagac tgccaagacc attggtaata atctgcacaa ctgcaaatgc agcaaatatg
    14701 gatgcatagc tgcttttttc aaattggtct ccgattatgc cataagtagc cggcaccaca
    14761 attcccgcac cgattcccat aatgattctt gcagcgatga gctgcagcat ggaactgctg
    14821 aaaggggcgg cgagagtgcc tataccgaaa agcagagatc cggcaatgaa attattctta
    14881 ttaccaaatc gttcacatag actgctggat aacaggatta ctgcggaaga tgccagaata
    14941 tagctgacat gcacccatga ataaaaggca gtggattgaa attgtctgct gattgcaggc
    15001 agtgcactgc tgaagtatgt ctgcatgaca gttgacgcac ccatacagag aagtaatccc
    15061 gtaagtatgg taatcttttt tgatagcttc ataatcgcac ccaccccctt tttctggatt
    15121 atagcactgt tctgtgaaaa tatcaaataa tattcatagc tttaataaaa aatatcaaat
    15181 aagatccagt attaattttt gtattttttc ataccagaat gaaaaaccgt tgccaatcat
    15241 ttctttctgc atgcataata cagccagtac ggcaactgcg gaagcaatct cttcctcgga
    15301 agctttcagg aaatatcctt tgccagccca gatatgtttc agttttttaa taaagtccag
    15361 attgtcctgt gatgcatatg tgtcattgtt ccagaccata gattctaaaa gaccgctata
    15421 ttcactggtg taaaatttgt ttgtagaggt tttttccaga aacacatttg ccagatccga
    15481 aaaaaatgcc tgaggtgtct gattttcctc gtcaatgatt gtcagaattt tctgtcgtat
    15541 tctgttggtc tcatcccgca ggatttcttc gtaaagagcc tctttgtctt tgtagaaggt
    15601 gtaaaagcct cccatggaaa tcccggcctt tttggtaatc tcctgtattt tgcagttttt
    15661 aaacccttcc tccataaaca tgagagaagc gatgttcttt atttttctct ttaattcttc
    15721 ccgttcttcc tccgtgtaag gtcgtcccat gatgattacc tccttttcca gcatgtaatt
    15781 ctatattaac ttgccgcctt aaattcgtca atatcagatt tactctgatt aattacccaa
    15841 taaatcgaaa acaaattatt gatttgtcga atagaatgaa gaagataaac caagaaaaaa
    15901 aggaaaaaaa gaaaaaataa gtcgaaatga aaataaacag gtcgaacaat gtatggattt
    15961 tgcgcttaaa agaccaaata aacaggaaaa gtagattgac aaatgaaaaa ctataggtta
    16021 atacatgtag tataaataat ctcagatctg tatatttatg aaaattctta gataaatcca
    16081 atgtttagtc agttaaaagc tgttttaatg ccgatgttca ctcaaaatac tatggaacag
    16141 tttgcttcaa ctaactaata atggatcgag aaaggggcgg gaatatgaat gagatttact
    16201 attggtctcc tggagtacag ttttatgtaa aggaagagga actttacgtg gaacggtttc
    16261 gatacggcag acaggcggct cagttttttc cagagtttta ttatatggcc cagaatggag
    16321 ctggaaccga tgatctggaa aagaggtttg agacagacaa caagagtctg ctgaaaaatt
    16381 taatacagga ttttattaaa aagaaaattt tggtatgttc agtaatcaca ccaaaggaac
    16441 tgtttcatag tcagacaagg ctgtttgaga atgattatcc ggaaaccatt cgatttgtca
    16501 aggaggaatt ggaagagttt aaaaaggagc agtcaggacg ggagcttgta aaagacgggt
    16561 tgacctatat tttaaaggat tcctattatt gcaatgacat aatttaccgt gaaacagttc
    16621 ggaaattttc aaagaaaccc attacatatc attctttttc aagaatattg ggggctttgc
    16681 aaaacaggga ggacagaaag ggaaccagat attatcccag tgcgggcggg ttgtacccgg
    16741 ttgatgtcta tgtgcttgta aaacccggca gagtggaagg agtggaacag ggattatatt
    16801 attataaccc cgtaataaat ggaattacct tagttgataa gggagaaaac atcacggata
    16861 agtctcagtt tatcaccaat caggagattt tttcgggctc agcatttacc atatattttc
    16921 tgtacaacgc cagatgcagc atgccaaaat acagcggtat gggttactat tacgggattt
    16981 tggattgcgg gattatgaca ggccttatta cccggatcag cgaagaggag ggaattggga
    17041 cctgttccat tggagatatg ttatatggga aaatagaatc ctgttttcat ttaaacaaga
    17101 gtcagttatt tctgcattcc atggagtgcg gttacaagga tgaagctgag agtgagcagc
    17161 caaaggagaa ataatatgag ctttaagccc ctgcataata tgccgtctcc ggaacagtta
    17221 agagaggaat gtccggtttc ttgtaagctt gccgccagga agctggaaag agacagggaa
    17281 ctagctgcag tgatccagaa tcagaccaat aaatttctgg ttattgtcgg cccatgttcc
    17341 gcaagtaacg aggatgccgt atgtgattac gcaagccgct tgtcaaaagt caatcagaaa
    17401 ttaaatcaaa agctttttta ttattccgcg gatctataca gccaaaccaa gaaccaatgg
    17461 atacggttat aaaggaattc ttcattatcc cgagaccagt acccattctg atcttgttaa
    17521 aggtttgaga gcggcaagaa atcttcattt aagggttgcc ggggaatcag gtctgacaac
    17581 ggctgatgaa cttctttatc cggaagcttt tgcttatttt caggatattg taagctatct
    17641 ggccatagga gcacggtctg tagaagatca gcagcaccgc tttgtttcca gtggagtgga
    17701 ttgccccgtt ggtatgaaaa atcccacaaa cggaaatcca gatactttat tctattcgat
    17761 ttttgcggct cagcatggac ataaattcat atacagagac agagaggtaa agagttctgg
    17821 aaatcctctg gcccatgcca ttatcagagg gtacgaaaat attatgggag aatatgtacc
    17881 caactaccaa tacgagcaac tgttaaaaat aggggagaga tatagaaaac aaaaacttaa
    17941 aaatcccttt atcatttgtg atgtgaacca tgcgaactca ggaaaggatt actccaggga
    18001 gccaatgatt atttatgatg tactggaaag ccggagaaga tcagaagaga ttcggatgat
    18061 agtcaggggg gtaatgatag aaagttttat tgaagcagga aggcaggaga tttccggaac
    18121 tgtgtatgga aagtcggtta ccgatggatg ccttggctgg aatgagacag aagaactgtt
    18181 gcattacata gctgaacacg tatgagaatt tgaaataaaa gggggaagca tctatgaaat
    18241 cacatttacg cggaaagagt attacgataa aagcaccgtt tcacacattg cctgattaca
    18301 tggaaagagc cagggatgac ggttatattg ttttttgctg acagaaaggg agaagaatcc
    18361 agactgagat ttaaagagat cagaaagaaa gcaaaacagc tggggtgtgt tatgttagaa
    18421 atgggaatga aaaaagggga taagctggtg tttcagatca gtgatcccca atcctttatc
    18481 atttctttct gggcatgcct ttataccggt attattgcag tacctataac aactgcagca
    18541 gaaataaaaa cagcgaatat taataaaaag ctggaagctg ttctggaaaa gcttgaatgg
    18601 ccccggctga ttctggaaga agaactgctg tgtactcttg gggaagatgt gaaagcacgg
    18661 ggaaatatcc tgatttatga ggaaatgaaa aagcaggcag aaagcagcat tcttttgttt
    18721 tgtccggagc agattactgg agaagatacg gcatatatcc agttttcatc gggaagcacc
    18781 aattcgccaa aaggtgtggt attaaagcac agcaatatta tttacaatgt ggaacagatt
    18841 ggcagacggc tgaatctgac agaaaaagat gtttccgaaa gctggatgcc tctgactcat
    18901 gatatggggc ttgtaggatt tcatataacg actttctgca gaggtatgaa tcaaattatt
    18961 ctatctccca tgaatttcat aaaaaatcca acctactttt atcaaaaagt aaaggaatat
    19021 aagactacaa ttatgggtat gcccaatttt gcctttgact ggtctgtaaa aatggtaaaa
    19081 gaaaagcatt tgaggactct ggatctttcc agcatccgtg cagttttaaa tggtgcagag
    19141 cccattaata ttcactccat acaaaggttt aacgagaggt ttgctgcctg tgggcttgat
    19201 cccaatgcaa tgcttccggt atatgggatg gcagaggcat gcattggtgt aaccatcccc
    19261 cactgcggcg accgtctggt tgaggtgaaa aaaagtccgg cagaaaagaa aggttatgtt
    19321 gctgtgggag aacccttgga tggaatcgat gtgaaaataa cagatgaaaa tgaagagata
    19381 ctggaggatg gtcagattgg agatatattg attcatggtc ccaacttaac ctgtggttat
    19441 tacgacagtg cccttatcaa tgaggaaagt ttttcaaacg gctatttaaa aaccggagat
    19501 atgggcttta tcaagaatgg aaggctcttt attaccggca gaaaaaaaga tatgtttttt
    19561 attaacggac aaaactgcta tctcagtgat ctggatattg ttctttcaga gagtggaatc
    19621 aaagactgtg ctgccgttta tgacgatgag gaaaatgaat taattgtttt tgtcaagcat
    19681 ctggggatag gggaaaaggc tctggagaca gagagaaaaa taaaagaggt ggttcagaga
    19741 acgttccaga tctctgtccg gtctgtatta actgttaaca atattccgaa gaccacaagt
    19801 ggtaaggtgc aacgatatca tttgctgaat gattacagaa aaacatttaa aaacaacgag
    19861 atcatctggg gaaagagaga agaaggttcc actataagtg agcctctcgc ccggatgtgg
    19921 aggcagatcc ttgatgcgga accagcagat accaacagtt tttttgatct ggggggggag
    19981 attccattaa actgattgct ttgttaagtg agatagaaga gacctttgga gtagagattg
    20041 aagtagaaga tttcttaaag caaccttatt ttacctattt gaacacctgt gtttcagaga
    20101 aaaaggacac ggtgagaaat gatgcagcag ataaaaaaat cagggagttg ccagatacca
    20161 taccggcaac agaacttcag aaagcttatc tgattgggcg tgaagaggga attgctacaa
    20221 aggtattgta tgaattatca acttcatggg agattgaccg gctggaaaag gcagtaaact
    20281 gcatgataag gagtcagcct gcccttcgtc tgcgaatatc cagagagggg gttatgcacg
    20341 cagataaaac cggggactgg tactgcataa aaacaatgga tctctcccat atgacagagg
    20401 aagaaaaagc aaatgcactg gatcaggagt ttgaacttca gaaaagaaag gtatttgata
    20461 ccgaaaaaga accgcttttt accattcagg ccataaagat gagagcaggt gacacgcggc
    20521 tgctgattca gatggatatg ctgattgcgg atggaatgag tctgaagctt ttcgtagatg
    20581 gaattgcaga ctattaccaa catgagaatc agagcgatca ggaagatccg cgttttttcc
    20641 tttactgtct ggagaagcag gaggaaaaac attccaggca atacaacaaa gacaggatgt
    20701 actggctgga cagactggaa caatttccat cagcgcctcc attagctgta aatcatattc
    20761 cccaggaaaa tactcaggga tttgggcgaa agaccgttac aattgacaaa cccagctggg
    20821 acaagataaa agaggaattg aagaaatatt ctgtcacacc ttctgttctt attatgagcc
    20881 tgtatgcaaa gatattgggt ttatacagcg gttccagccg gtttacattg aatgttcctg
    20941 tgtttaacag aaagagcacc cgtggaatga tagatgcaat cggagatttc acgtctgttt
    21001 tactgcttga catagatttg tccagggaga acctgttgga tctttgcacc agcgtacaaa
    21061 aaaaaaacat gctggaagca ttgatgcata agtcctttga cggaatcgaa tttatgcggg
    21121 agattgcaaa ggtaagggga acgaaagaag ccagctttcc agttgtgttt acatccttgc
    21181 tttctgatgc ttttgaattg aatctggata aaatcggacg tatggtcaga ggttatagcc
    21241 agacttccca ggtggagctg gattgtcagg cttatgagga aaaaggttct cttgtaataa
    21301 actgggacta caaaaaaggg gtatttgagg gtaacattct ggaacgtatg ttttctttgt
    21361 tttattatga cctggcagga ctttgtacag acaccggatt ctcctctgga atctcagaca
    21421 gaggctttct taagaggctg ctgcatcagg atatcgaaat gatccatgct tacaatacca
    21481 cagaagaaga cattccttat gtcagtttaa atcaacttct gatccaggca tatgggaaat
    21541 acaaagataa ggctatttta tcctgtggag aaaaaaccat gagctatgaa cgtttgtggg
    21601 agaaatcagg cagggtgaaa aattatttaa aaatgaaagg tgtaaaggca ggaagtaacg
    21661 tagcagtaat cggaacacgg gattttgata ctgtgatcaa cattctggga gtaatccgca
    21721 gcggagctgc ctatattcca attgatgaaa tccagcctga ggaaagacga aagctgattc
    21781 tggaaaaaag cagcagctct gtgattcttg aacgtaatat ggattatacc cattttgaag
    21841 atgatgggga acaagaagaa ccagtcagtt ctccagacga tattgcatat attatattta
    21901 cttcaggcag tacaggacag cccaagggag tctacgtaaa acacggcgcc gtcgtaaaca
    21961 caatactgga tattaacaga aagttccaag tatcagatca ggatgtaatt gcctgtgtct
    22021 cttcgattgg ctttgatttg tcggtatatg atatttttgg tgccctgatt tcaggagctg
    22081 agctggccct gataccggat gttcatgata cagagcagat gatgacgatt ctttctgaaa
    22141 gaggagttac tgtatggaat tccgtaccgg cactgtttca gatgctgaca gattgtctga
    22201 agaatgacag atcagaaagt gaagagtatt ttgacgatta tttggaaagc ggtgatactt
    22261 tccgccgcct gctttctctt aagctggtta tgttaagcgg cgactggatt ccaaagaatc
    22321 tgatacagga ggcgtacggg tattttgaaa attgccgtat gataagcctg ggtggagcca
    22381 cagaagcgtc agtctggtct atttattatg acattaagga ggtaaagaat cagtggacct
    22441 ccattcctta cggctatcct ctggccaatc agaacatata tttactggac gaagtcgatg
    22501 attttgtgcc tgtcggtgta aaagggcaga tatgcatcgg cggaatcggc gtggcagaag
    22561 gctattatca ggatcaagaa aaaacagatg cagcattttg taaaaaagag ggactgggaa
    22621 gaatatacca tactggtgat tatggagtgt tttcagaaga gggctgcatt ctctttctgg
    22681 gaagaaaaga tgggcagata aaaatcaatg ggttccgaat cgaactggga gagattgaaa
    22741 atgctatcaa agggctgcct tacgtcagca acgcagccgc ccttgttcat gaatataaaa
    22801 gcggagttaa atccgtctgt gcttatgttt gtaccagtga aacgattagt gaacgcaaag
    22861 taagagatga tttaagcagc attctcccat attatatgat tccttccacc gttgtttttc
    22921 tggagaggat accgctgacc ggaaacggaa agctggatag aaaaagtctg cctgtcatta
    22981 aagagcccgg agagcttatg gaccgggaac cacaaactca gacgcaaaag gatctttatg
    23041 agatctggaa gaaatattta aaaacagatc atttatccgt cagcaggccg tttatggaat
    23101 tgggaggaga ttccctgacc atgatctcgg tggttcatga aattaaatcg aaatttggtt
    23161 tagaggttcc atttcgggaa tttatgatgg gtgggtccat agaaagtatt gcagaattta
    23221 ttgaaagcag caggaagaag ggcgcagcag gtttaaggga atacacggct gttacaggaa
    23281 aacagaggaa aaatatgact gctttccgtt aacagatatc cagaagtcat atttggtagg
    23341 aagaagcagc gggttaaaaa tggggggcgt ttccactcat gcttattatg aggttgaaaa
    23401 tgattttgat attccccgtc tgaccagaag tttaaataaa gtgatctgcg caaatcccat
    23461 gttaagagca gtggtcaata cagatggtac ccaacaaatt ttagaaaatc cgggctggtt
    23521 tgagataaaa gaactggatt taacccggtt gacctcagaa gaaaaagagg aaattctggg
    23581 aaaggcgagg gaagaatatt cccataaagt ctttgaacag aataagtttc cactgtttga
    23641 ttttcttgcg tatcgtctgg cagaagacag ggtaaggctg ctggcaggct ttgatttact
    23701 gattgccgat ggaatcagca tgagaatcct gatcagagag gttatgagac tgtatgagga
    23761 tgaacatatc gtcctcagtg agaatacctt tacattccgt gactacatac tttccgtaga
    23821 ggaaatgaaa aaaagtccct attataaaac agcagaagac tattggaaaa aacaggcgga
    23881 atgcttttca ggagcgccgg atcttccaat gattcagacc ccggacgaaa ttgagaaacc
    23941 ggtatttcgc agactgattc ataaaatatc cactgaaaaa tggcaggctc tgaaagaaaa
    24001 aataaagggg cattctttca ctgcatccac atttctcatg acactatatg gcagaattct
    24061 tgccgcttac agcaatcgaa ataccgttac cttaaacgtc acagtattta cgaggtttcc
    24121 atttcaccag gcagtaaaaa acatgattgg agattttaca tctgtcatgc ttttggatat
    24181 caacggcgag tctgtagaat tgtgggaaga gtgcttaaac gtacagagga agatcaccga
    24241 gaacttagag cacatggaat acgatggagt aagtgtaatc agagaggttt ccaaaaggca
    24301 gaatcgggtg gggggaactt ttatttcctt tcgtttttac aggtatgatc tttgagaatg
    24361 aggacggaat cagtctggaa aatatgggta aactggtgta cagcgtaagc cagacatctc
    24421 aggtttatct ggattgccag gtaatgacag gcagtgacgg acttagtatt acctgggatt
    24481 atgcacagca gttatttgac ccggttatga tggagcggat gtttgaacgt tttaccgcta
    24541 ttattgaagc agctggtgag ggaagcatgc tttcagagag agagtcagca tttgtggatc
    24601 aatataatca gacggattgt gatatggaat ccataacgct gacagaggca tttgaaaaac
    24661 aggtcctttt aaggggagac catatcgcac tggtcaccgg ggaaggaact tatacgtatc
    24721 agatgatcaa cgatatggct gaaaaaatgg cagcaggatt aaaaagaaga gggctaagaa
    24781 atggggataa ggctgcagta tacgaataca ggaatgcgca gacaatagct gcaattcttg
    24841 cggttttaaa atgtgggggt gtctacgttc ccatcagccc gggtattccg gagaaccgga
    24901 aagaatatat tctggagaac agtggcagta agctggaaat tacggctgat ctggctgaag
    24961 aacttaagca ggaatcaggc tgcttacata aggaaatcga aacagaggca gatgacactg
    25021 cttatatcat ctatacatca ggcagcactg gtgttccaaa ggggggttgt gatcacacac
    25081 cgggaggcta tgaataccat tttggatgta aacagaaggt ttgaaattac ggaaaatgat
    25141 agaatatttg gagtatcctc ttttactttt gatttatccg tatatgatat tttcggaacc
    25201 tttgcggcag gtgcagcttt gattctggcc ggggataata aaaatacgga agaactaaac
    25261 cggcttgtca gtgaggagga agtcactgta tggaattccg tacctgcact ttttgaactc
    25321 ctattatccg tcagagaaac ggctgaagaa aactacttcg atgagattaa tcaggaactg
    25381 gaggtaaagt ttgaacagac agaatcctta cggattgtca tgctcagtgg agattatata
    25441 ccagtggatt taccggaccg gatcagaaac aggtatgaaa acgccagagt aatcagtctt
    25501 ggcggcgcga cagaagggtc catctggtcc atttactatc cggttaatag ggtagaaccc
    25561 acatggacga ccataccata tggatatccg ctgggaaacc agaagcttta tatcctgaat
    25621 gacaaccaga aaatctgtcc cattggtgtt ccgggagaga ttgtcattgg cggagcagga
    25681 gtagcacagg ggtactgcaa tgacccggaa aaaacctccc gatcatttct tgagactgcg
    25741 tctcttggaa gaatatacag gaccggagat atgggagtat tgactgaaaa agggtatatt
    25801 gatttcctgg gaagaagaga caatcaggtg aaaataaatg gctaccgggt ggaattaggc
    25861 gaaattgaat cagccatgct ccgctttgag ggtgtgaaac gtgcagtggg cacagtcagt
    25921 gcagacaata gaaacaggct gattgcatgc tttacttcag atgaaaaaat acctgttgaa
    25981 cggatccgtg aatttcttac tgataagctg ccttattata tgatgcctgc tctgatcaga
    26041 caaattgaaa ccattcctct tactgctaac gggaaaatag atagaaaaca gctgagctat
    26101 atggacaagc tgcctgatga acgaatcgtt cttgctccgg aaactgaaaa tcaaaaaatt
    26161 ctgtatcagt actttaaaga ggttctgggg gtggatcagt tcagtataaa agataatttc
    26221 tttgaactgg gaggcgactc catgaaaggc atttctcttt ataataaaat caatgaagta
    26281 tttgaggcgg atatgaacct gatcttccgg tatcagacag tggaagccct tgcagccaga
    26341 cttataaaga gaaaatctga ttataaggag gagcggctta agcagtttaa gcagcaatat
    26401 gtcgccgcag cagatacgct ggatgcgcag aaaaaactgg ctgaagatta taatacctat
    26461 cttaacaatg ccgaaaaaaa attaaaaacc tttaagacca ggggcagcaa agattataaa
    26521 gctgtattac tgacaggggg aaccggatat ttaggagcca atttaatgga aaccctgctt
    26581 accaccacag atacgttaat atttgcgctg gtcagaggtg atgactacat aaaccgcctg
    26641 aaggagaatc tgatctttta ctttggtgaa gcgttctact ccaggtacag gaatcggatc
    26701 gtggcgtttc agggagattt gtcccaggaa atgctggggc agaaaaagga tggatacgaa
    26761 agtctgtgcc atacggtaga tgcagtattt cattgcgctg gtaaagtgga acattttgga
    26821 aagtatgagg atttttacag aagcaatgtt aaaagtgtgg aaaatcttct gaaattcagc
    26881 atggaaggaa aacaaaaaga actgtgtcat atgtccacaa ccagagtgat ggaatccata
    26941 gaaagcaatg atatagaagt tctgttccat gaggattaca agggaattaa cgggaatgcg
    27001 gaagaattat acgtaaggtc aaaaaaagag gcggaagact taatagaaga ataccggaaa
    27061 aagggagctt tagtcaaaat ctttagaatc ggtaccattg tatttgacgc cagaaacggg
    27121 aaattccaga gaaatattga ttttaattca ttttatctga tcatgcaggc gttttttgaa
    27181 ctgggtgcca tgccaaatgt ggatgctact cttttggatt ttacatttgt ggatgagtgc
    27241 agcagagcca ttgtaaaact ggcaatggaa aaagaggtga agaatggaat ttatcatatc
    27301 tataacgaga ataagcttgg gatgtatgaa ttctatgata aattaaagca tgcaggaatg
    27361 aaggaaaatc tggaaattat ggaatttggc caatttttcg attttgtata cgacagttat
    27421 aaaaaagagt ccctggaaga ctgtattaat acacttctgc ttcattccag cgcatatatg
    27481 tctctggaag gagcgatgcg tgtcattgtt aatgactata ccagaggcat tttggagtct
    27541 atgggattta agtggtcaag agtaagtgaa gaacatatca gaggcatgtt ggaatatggc
    27601 aagaaaatcg gattttttaa gaaggaggtg atcgtatgag gctgaaaaat tttatagacc
    27661 acatgaatgc ggttcatagc agcgctaagg aatattacca ggatatgaat tacgatattg
    27721 tgccggggct caatggaacc aatcatgcac gctggatgaa tgtaggttat tggaaacatg
    27781 cagcctatta taatcaggcg tgtgagaagc tggccatgct attaagcaga gcgggaaaat
    27841 ttagtgagtc ggattccgtt ttggatgtgg gctgcggaag cggagagcag gattttttct
    27901 ggagcagaaa atatccggga atatccatca cagccatgga tttgttggaa aagcatattg
    27961 aagaagccat tgtacggcaa aaaaatgagg aaggcacatc cattcggttc atggctggaa
    28021 cagcaagcag gcttcccttt gacaacgaat catttcataa agtttctgca ctggactgcg
    28081 cctaccattt tgacaccaga gaagatttct tccgtgaggc tcatcgtgtg ctgaaaaagg
    28141 gaggagtatt aactgctacg gatatgcttc ctgaaaagca gacgaaaaaa aagtactttt
    28201 ggcagaaaaa atggcgggaa gggctgttta taccggaaga aaacatgtat gacattaact
    28261 gctatgtaaa gaaattaaag gcagctggtt tttcccagat taaagtaaag cacattgggc
    28321 atgaggtatt tacaggactt gcgtggtatt ttctttcccg tttcctgatg ccccataaac
    28381 ccattgagca aataaagata cgtatcggaa gagttagctt ttttagcagt ttttatccta
    28441 aaatatgggg gattctgttt ggaactccgg attatgttct ggttactgct gttaaaaatg
    28501 ggaaagagga gggaacggtt tgatttattc agttggtaca aattttgatc tggagctttt
    28561 ggatgtcatt aaaaaatatg acaccaaaaa tgaaattaag tctgtatttg gaaaattgaa
    28621 aattgatgat tttgggggag gacgatgttc catggtgctt cctgatgtga gctggaagga
    28681 gttagagcag tatattgccc agtgtcataa gcaggacatt cagtttaatt atctgataaa
    28741 tccaatgtgt tatggaagtc atgaaatgga acgagattat aataagaaac tggataaata
    28801 tttagacaga ctttccaaga taggtgtgga cattattact acgaattctc cttacatgct
    28861 ggaaagcatc aggaaacgat ttcctcattt taaagtaacc ataggtcttt atgcactggt
    28921 ggactcactt cagaaagtga aatactggca ggatctgggg gcagatgaaa tcacgctgaa
    28981 tgataatttt atgagaaatt ttaataagct ggaaaatctt ttactggtca caaaaggaac
    29041 aggattaaag cttcggctta tagccaataa catatgcctc catgactgcc cttacagtgt
    29101 gagccatggc aactctcagt cacatgccag tgaaaaaggc agttcctctg ctggttttag
    29161 tgtagactat tgcatgctca aatgcacaat gacccgtttg ggagacccct cacaattcat
    29221 caaatccgcg tggatcagac cggaggatat tgttcattac gaggctctta tggaaaagac
    29281 gggaaattat gatttttcca tcaaattact tgacagaaca agaactacag agtttctgga
    29341 acaggtaatt aaggcttata cgcagcgaag ttatgatggc aatttccttg atattgtaaa
    29401 tcttccatca accaaagcaa ttaaaaatat tgacatgaaa ggggttatac caaaagcatc
    29461 ccagttcaac attcagggcc ttatgcagta taaggacatt ttcaatatcc ctgatgtata
    29521 tatggacaat aaagcgttgg atggtttttt gatgaaattt gtaaatggtg agtttacctg
    29581 cggagatcac gtatgcagag aagttgtggc tgacagcaga gtagagtgta attactgctt
    29641 tcagtggtca aaaaaggcaa tccgcagttc taacgaggat ataaaggcat ggaaaggaaa
    29701 agcagattcc attcttggac aactaaattc aggagatttt tacaaattat tctagaaggg
    29761 ggaggagaaa catggaaaga gcgtatcatt tatggaaccc gtttacggat ctggaggaat
    29821 ttctgcctta taaggatgta ggccctatga ctatagtcag aggagaaggc ccttttgttt
    29881 ataacgaagc cggaaaaaag tttatcaatg ccagtggttc tttatggaat gtagcagttg
    29941 gacatggaag agaggagctt gcagatatag cattcgaaca gatgaaaaaa ctctgctatt
    30001 catcctgttt tcgccagact catccaaagg cttgcgagct tgcagattgt ttgtgtgcgc
    30061 tgactgggaa ttactatgat aaagtttatc tgggaagcaa tggttcggaa gcagttgaaa
    30121 cggctcttaa gttgacgagg cagttttttc gccagagtaa ggcagaagag aaacggggga
    30181 aatataaaat tctctccttt aaaggctgtt atcacggagt aagctatgga gccataggtc
    30241 tgtctgggga tgagatcaat gaaaagctgt atgcgccgct gccgggagga cttttgcagg
    30301 tggaaccgcc ttattcctat cacggggcat atggaaccaa aaaccaggcg gaatgtgaat
    30361 tgaaatgtct ggaagaaatc caaagagtga tcgagagaga aggacctgat acaatggctg
    30421 cctttattgc cgagccggtt atgggagaaa gaggaattat aacaatcagt gacagctttt
    30481 ttgatactct gatggaactg ttagaccggt atgacatgct gatgattgca gatgaagtga
    30541 ccacaggatt tggcagaaca ggagaacttt tcgccacaga caggtggcga aaacggccgg
    30601 atatcctctg tctcggcaag ggaatcagca gcggttatct cccggtttcc gccgtattgg
    30661 caacaaaaga agtttatgag aattttaaag gtgaggatca ctattttcag catggaagta
    30721 cttccagcgg aaatcccgta tgcagtgcag tggctcttgg taatattgat attattcttc
    30781 gtgagaatct ggtagagaac tccaggaaaa ccggagaata tttaatggga aaaataagga
    30841 gtctgatgga agagagacct gtgttaggtg aggtccgggg acgtggtctt atgatcggta
    30901 tggagcttgt taaggaccgg gtttccagag aaccgttaag cgagtctgag atgtttgaaa
    30961 tagttgctga ctgtgcttcc ttgggagtga ttgtttatta taacagaaat gtgattgcgc
    31021 tgtttccgcc tcttattatt acaaaagata ttgcagatca tatttattct gcattaaaga
    31081 cagcattgga tactggtcag aaagaagaga ttctgaaaag aagaggttat taaaagagtt
    31141 agttacttct aaactgagaa cagccaattc ataagtgaaa ggggaagagg aagttgaatt
    31201 tattttgtat cccctgtgct ggcggtagtg cggtcatgtt taaaaaaata caggatctgc
    31261 tgcttcgaaa tgtaacggta aggccaatgg aactggctgg cagaggcagc cgttttgcgg
    31321 aagaacctta tgcagatgtg agctgcgctg tgaatgattt atatcagaaa atcagtggct
    31381 ggattgacca ggaggactac tgtatcatgg gctttagtat gggcgggatt cttacctttg
    31441 aattgtgcag aaagattggg caaatgggga gaaaacttcc ttcgggagtt tttttcctgg
    31501 gagtagagcc accccacatt aaatccggga cagaatatta caagctggat gatagggaat
    31561 tcagacaggc aatgatctcc ataggcggaa taccagagga agtatcacaa tgtgaggaac
    31621 tgtttgacct atacttacct gccttaagag cggattttca gctttgtgag tcatactgtt
    31681 tcactgggca gatcattaaa tttgatttta atttttattt gattaatggc ttaaatgatt
    31741 caatcagccg ctgcgttttg gatcagtggg catggtattg caaaaagtgc caattggatt
    31801 ttgtaccagg tgttcatttt tttataaata ccaatacatc agaaacctgc cgttgcatta
    31861 acaaaggctt aaaggaaata ttaaattgtt gattgtatga tataaactca aagaaatcac
    31921 agcaggggat aggtatggta tttgtcaatt gtatggatat aacagagtgc aaaaatgaac
    31981 tttacgagaa agccattcat atagtttcgg aagaaaggag gaaaaagtca gaatgttatc
    32041 attatgtaga tgattccaaa aggtgtattt gtgctggctt attacttcaa tatggatttt
    32101 atcacaaagt tggtcaatta agtgaaattg aaatcacgta caatgaattt ggaaagccat
    32161 ttataaaaaa caggaaagaa tttaaatata acataacgca ttctgggaag tgggtggcaa
    32221 ttgtatatgg taccactgag gtcggaatag atgttgagaa aattcaggaa ggcagagaag
    32281 agttagtgga tttttgtttc tctgaagaag aaagattaac aatttataat cacatagaaa
    32341 aagaagaacg gataaaacag tttacaaaac tatggactat gaaagaaagt tatataaaat
    32401 ttcttggaac aggactttca acaggtctga aatcattttc tgtagattct acggaaggat
    32461 tgataaccag taacgatggt aagttaaaaa aggatttaag aataagaagt taccaatttg
    32521 ctacagatta ttatctatct gtatgcagta cggaggatga gatttgcatc cataacgttt
    32581 cgttgaaaga ggtagtaaac ttattagaat gcatgtaaat tccgaagaat ctgcctttca
    32641 tggtataatc agatatgcta atacttagtt acactacaaa aaattatagc agtataccgt
    32701 atagtatcag attaagaatc cgggacttgc tcatgagcga atcccggtat attcaatcct
    32761 tattttctga atatgtcaat agcatgactt gttacaccaa gtaaatctgt ctgcggcaac
    32821 ataatgtagc cgagttacag gaaatatgga catcaaatca tcaatatatt ctttgcggac
    32881 aagttcaaac aaatcttttg gctctgattt ggcggcaaat gtctgtgaat caattaatcc
    32941 ttgttcaata tattgaagaa cattgatatt tccacgattg aaaccttcgt caagcagaca
    33001 accatcggat atgacgtagg cggcaaaaac gataccaccc ggtttggtta cacgtatcgc
    33061 ttcactcaga gcttgttgtt tgtcctcttt tgtgtaaaga tggtataacg gtcctaacag
    33121 cagagtaata ttatattcat tgtctgggta tgccgataac tccatagcgt tgccttgtgt
    33181 aatagttata ttttcattta ttttagtgtt ttgcttgaaa atttctatat tgtgttcaac
    33241 caattccact gcgtcaactt tataaccctc ttgtgccaac gcatgggaat accgaccagt
    33301 accagcacca atttcgagca catgattacc ggtttttatg tatttctcga tatatttcat
    33361 tgtggtaagg aattctactg acccatgttt tggaacaagg cggctatctt catcataatt
    33421 gttgtaatgg ttaattaaat aatggtttac attcatattg taccccctct gttccaatct
    33481 ggtttgtatt gtctaacaaa agctgttaga atgtttgtta ccatcttttc agcctcatct
    33541 ctattaaatg ctattttttt tgttgcagct agaacagcta tgccatgtgc ataaaaaaat
    33601 aagtctaaaa atatgatttt tgattgttct aattctacgc ctattgtatc cgagaatagt
    33661 tttacattct tctcattatc aatttcatta taaaagtcta ttgctttcgt catttttaaa
    33721 tctatattat ttacgaataa taatttaaat aagttggttt cttcttgagc gaattcaata
    33781 taggaaagtg gaaaaaatta tatatgggct gacactaaca gaattataat aattgtttac
    33841 atatttcttg taatatctat aagaaaaatc caaaaaaatt ctgtttttaa ttcatccata
    33901 ttttttatag caagtaaaat aggtcgagta gaacaaagca gcttatttga aatactcctt
    33961 gcattaacag tttcatatcc cgtatctctt gtaatatcaa agacaatatt caaaatcata
    34021 tcttttgtta tttttgcttt aggaggcata ttaatgatat cctttacttg acgtataata
    34081 atacaatggt tacataacaa tagttacata acgtgcaaga tttgtcaaat gtttttttat
    34141 tttaaataat aattagtgta ctggtacatt taagaaagtg ggtaagccaa cgctttaccc
    34201 actcaattgt tacataaggc ttttaacaaa ttcgacaggg tacatggttc tctccgcagt
    34261 ttcctcaacg ctaagtccct gtgccaaaaa acgttttgct acacttgcca tgctttcaga
    34321 cacttcaact ataaatttat catagtcata aaatctcata acccgctgtc cccacggata
    34381 ttctttcgcc ttgtgaataa attctattcc ttctgtactg ctgattttat tctgccaata
    34441 atccaaatcc tccacttcaa agtaaagctg aaagttgttt ggctgtgtct tgccgggcaa
    34501 atctgcacca acaagttccg cgtaattaga ttgcagggaa aatccgccaa aagacacatg
    34561 cacgcccaaa tccattataa ccttttgctc catcacagtt tcataaaatt gctttgtttt
    34621 ttccatatcc gatacggcaa tcaaagtacc ttgatattgc atataatcac tcctttttcg
    34681 ttttactaaa ttatatatca gaatttagca atctcgctgt aaaaatcgga catattatcc
    34741 cggtactcct gaggagtaat accacaaatg gccttaaaat catggatgaa gtgaggcata
    34801 tcataaaagc ctgtttccat aaaaacctgc gttaagttat agtcatgtcg ctgtaaaagc
    34861 cgtatagacc tgtttacacg tacaaggcgt gagaaagact ttatccctac ccccatatat
    34921 tcgtcgaaaa gccgtcctaa atggcgttcg ctataaaaaa cattctgcga gagctctttt
    34981 actgaaaaag taccgccgct atttataatt aaattacttg cttgggcaaa ctcctggcga
    35041 taaaaggcac cttttaaatg cgcaagaaac agccggtcca ttttcgtaat cagttcctga
    35101 atacttaacg atgtttctaa ttcatttgcc atcaggcggt tcatagagga attaacatgt
    35161 tcaaagtcaa tgacacaatc tgttatttct ttttgcggca ttccgctaaa ggcataatag
    35221 ccagctggct gaaactctac aataaacaaa agactgaaat tattggctga cttgccaaca
    35281 aaggaaggtt tcgtgatggg tccaaacaag ttgccgtgga tatggctgcc agtacatgat
    35341 agcacaagtg tagcgctccc atgaggcata acagcgtaat tatctgacat cataccaata
    35401 actggaaagg taattgtgta attagaaatg aaatttctaa gctctgaatg tggttgaata
    35461 tatataaaat ccacgcctct tattagtaca cggctattat tcatataatt ttgaattgaa
    35521 tctttcataa gcatgtatca tcaccacctt cctgttttca ttttactaaa taaactttta
    35581 ttaaacaagg acaaatcagg taataataac gttgatgaaa tttattttaa ggagtcagca
    35641 aatatggata aaacacctaa aatagaagtt tgctcatact gttctggatt tgatgtcaat
    35701 gagttaaaaa ataaagcaaa ggtaaagatc agctgcattg gaaaatgttc taaacataac
    35761 ccggatttaa atggaaaggt atatggattt ctgaatggtg tctttacagt ttgtgatacc
    35821 aaggaggaat tctttgaaaa gattgacaaa ttagaaccct atcaattgaa tagtaatgag
    35881 aatcctttgg tagacgcatt tttggagcac cttgaaaaat ggcgggatga gcatgaaaaa
    35941 cttcgggagc tttgtctggc ctgtcagctg accgaagaat taaagtgggg acaaccttgc
    36001 tatacgttaa ataataaaaa tgtagttata attggcggtt ttaaaaatta tattgcccta
    36061 acctttttta agggagcatt gttaaaggat aaagacagat tacttgttca acagacggag
    36121 agtgttcagg ctggccgtca gctgcgattt acctcagtag aggaaatttc tgagagagaa
    36181 acgatgatca aagcttatat cgaagaatct atagaaattg aaaaggccgg tttaaaagta
    36241 cctgttgaaa agaaagcgga gatcccgatt cccgatgaac tgcaaataaa gtttcatgat
    36301 gatcctgcgt ttaaaaatgc attttatgca ttgacaccgg ggcgtcaaag gggttatatt
    36361 ttttatttta atggagccaa gatgtctgaa acacgaatat cacggattga aaagtatatg
    36421 gataaaatct ttcatgggtt ggggattgat gattaacagc ataatataga aaagcggaat
    36481 cgggcttagt cacctgactc cgcttttcta ttataagtta aatgtctttc tgaactgact
    36541 gggtgttatt ccgtgaactt cctgaaatgc tgcggtgaat tttgatggat ttttataacc
    36601 acacagctca gcaatatgat ggatgcttaa atgatcagag gagagaagct gcattgcccg
    36661 cttcattttt tcccttctga tataatcata aaggggaata tgataagtgt ttttaaagct
    36721 gaggcgaagt ttactatcac tcatatctgc aatttttgtc agttcgctca tagaggggac
    36781 atccaaaatg ttttcgtcaa gtgtttgctt cacagcatac atttttttct cattttccca
    36841 tgttacataa ttccgtctgt catttctccg atcaggaata acaggataat tacgcgcaat
    36901 ggaaccaaga aggtgaatca ccatgccctc aaatgcaaag ggcggcatat ccccatttct
    36961 gattgcccag cggatctgct caaaaatgag catggtacct ggggtattca gatgctctgt
    37021 ttcccataat ttcccatctt caatgctgat tttaggcgca ttggctctag cctgcaaaaa
    37081 gggttctaaa aagtcctgga aaattaaaat actggtaaaa caggtgtgga cattctttgg
    37141 aaaggtaaac tggaacgctt tttgaggatt tattaattta tggcatatgg gagaaaatgt
    37201 agttgcagct tttccctgct gagaataaat aatttcaccg caatcaatgc aaaaaagcca
    37261 gagacatggt tctttgatat caattttatg aacaatggtc tgattgggcg aaaaccacgc
    37321 actggagaca taaagcccct gtgctgggga gacttccaca atccaaccgt ttgaccaatg
    37381 gggcggaaaa taatgcccag tacccggtcc ataaggggtt tgctggaggt tatatttttt
    37441 tgccatagaa ccccaggatg catcatcata tttgttcatt aaaagcctcc ttttttcgtg
    37501 agatattgaa agtatactgg aaacaagggt ttaatgcaat taaaagtact ccattttgtt
    37561 ttaattataa tccgattata aaataaaatg aaatgaaagt gagtcaaaaa tacatataaa
    37621 cacagagctt tttgagctga aaggagaatg gcacttcctt atcttggaga acagctatat
    37681 tgacgaatat tttttattat gctagtattt attaggttag tctaaactaa caaaaaacta
    37741 aaatttgtga tgaaacaaac ataaaaagta tacgaggaga atggatatga aaaaaagagg
    37801 gctgttacta tgctccatga tgttgttatt cgttttatca ggatgtggaa aagcagaaat
    37861 agcaaataat aaaggaacag atatcaataa aattgatacg gttatgggag agattgaagt
    37921 accccaaaag cctgaacgtg tggtagtgaa ctggtatatc ggcgatgctt tttctctgga
    37981 tttaaatgtg gtgggttatt cagcctgggc acaggagacc atgccatttt atgataagtt
    38041 ttcaacatct gcaaaattgg aaaattgggc agcagaggat attatggcgg ttgagccaga
    38101 tttgattatt acatataaca cagaagattt tgagaatttt aataaaatcg caccagtttt
    38161 ggtgattccc gaaagtgagg taactccggc agaacggctg agaatgattg gtaaagccac
    38221 aggaaaagaa aaggaagcgg aggcactgat cacaacattt gatgaaaacc tcgcggctgc
    38281 aaaggcagag tttcaaagtg agatgtatga tggaaagacc tttagcatta tggaagactg
    38341 gggatctacc ggtgaatgga gtggtgtagc atatgaaacc ggctccagag gcggcaccct
    38401 ggtttatgac tatcttgggt taaaaatgcc tgaaaaactg gaagaactga ttgccaaaac
    38461 aggagaaaaa agaggatcgc tcagttatga ggtcgctcat gaatatttcg gtgattatat
    38521 cttgtggttc cagcaggagg ggaaggaatc cgaatatgca aagtctgata tctggaaaag
    38581 catacctgct gttttggaag gcagagtggc ggagattccg ggagagaatc ttggattgtt
    38641 ttactatgat gatatcgcca gtttaactgc acagttggac tatgccatta atgccatcaa
    38701 aaatatcgaa gtaatcatag aaggagaaat ctgtatgtta aagttcaaaa atacaggtgc
    38761 tttattactg gcctttgcca ttggaatttc tgtctcaggc tgcggttcaa agccagtgaa
    38821 atcagcagct gagggatcgg cagaaatcag agtgatcaat acggagcagg gggagataga
    38881 aatacctgct gatcccaaaa gaatcatagt gacatattgt gtaggagatg ccctggctct
    38941 tggagttaaa ccagtagcaa ctaatgatgc agctggcaca gcttatgaaa aagaattgga
    39001 tggagtgcct gtctgggatg aatttgaagc agaacagttg atctcttacg aacctgattt
    39061 aataattgtt gctaatcaaa aacaatatga tattgcttcc aaaatagctc ccacaattct
    39121 gcttccattt acaacccagt ccatggatga gcgggtacga tttatgggtg atgtgttaaa
    39181 cagacaggaa aaggcaaatg ctgttctgga cgagtttcac caaaagctgg agggggcaaa
    39241 ggcttctctt agggaaaaga atgttttgga taaaaccttc agtgtgattg aaagtgacgg
    39301 aaacggtggt atttgggttt acggtgataa atgggggcgc ggaggagatt tgttatacag
    39361 tcagctggaa cttcaggcgc cagaaattat taagaaggaa attattgcag cggaacaaca
    39421 cagagatgtt tccatggagg tcattaatga ttatatcggc gattatatca taattgccag
    39481 aggtcttgag gaattgaagg gaaacacaat ctgggaatct ttgcctgcag ttaaggcagg
    39541 aaatgtgatt cctatcgatt ttaccttgtt ttacgatatt gatatttact cctcaaacgt
    39601 acaactggat tatctgttaa atgctctgct gaaaacacaa gagtaatgtt attatcacca
    39661 cggaaaggaa cgacaccatg aaaaatacca caacaaaggg atggaagggt tccatcaact
    39721 ttgcctttta catggctctt ggatttggaa ttttattgat tgtttcggca gcctccataa
    39781 catttggcgc tgccgacatg agaattgcta cagcatggga ggcagttttt cagtttaatc
    39841 ctgaattaac agagcatcag attatacaga cactgcgcct tccaagaacc gtggcggatt
    39901 taatggtagg ctgcagttta gctatttgcg gtgcaatcat gcagggaact accagaaatc
    39961 cactggctga ttccggactg atgggtatta gttcaggatc aacgtttgct atggcacttt
    40021 gtatggcgtt tttgccaatg cgcacttacg gacagaccat gctgtttgca tgtatgggtg
    40081 ctgctgtcac tacagcaatg acttatttta ttgcatccat gggaaaggga ggaatgacac
    40141 cccagcgcct tgttttggcg gggatatcaa tctccatgct gtttggcgca ttcagccagt
    40201 atatttccat ccgatatcat ttgggacatg cccttgctta ttggacagca ggaggaactg
    40261 cgggagctaa atggagtgag ctgctgactg tttttccggc ttttgttttt ggtgtggttg
    40321 gtgccattgc actttctcct tccgtcacag tgctcagctt aggggaagat gtagccacgg
    40381 gtctgggatt aaaaacaaga tttgtaaagg gaatttctac gattattgtg ctcctgctca
    40441 caggactttc cgtgattatt gttggtccgg ttggttttgt gggtttaatt actcctcata
    40501 ttgtccggta ttttgtggga gtagattatc gctatattat tccagcatca ggactgtacg
    40561 gcgcgttgct tacggttttt gcagatctgg caggaagatt aatcaataag ccatacgaaa
    40621 cgcccatagg cattatcttt gccgttattg gtgttcctta tttcctctat ctggcaagaa
    40681 aacaaaggag ggaatttgag tgaaaaagaa aggctttatt ctgttattta tgactgttct
    40741 catggtgctg gtcgcgatta tcagtattaa ttcaggtaaa atgaacctta ctcctgcaga
    40801 ggtaatgagt gtgattttag gaaaaggtac accgaagcag aacctgatta ttatggactt
    40861 tcgtctgccc cgcataatac tggcggtttg cgttggaatc ggcatgggaa tttcaggctg
    40921 tattatgcag agtctgttaa gaaatgatat ggcaagtccg ggcaccctgg gaatcagttc
    40981 cggttcagga ctctttgtat taattttcgt tgtaattttt tctgcaaaat ccaattcttc
    41041 ggcaatctta atgcctgtat tatcgtttgt gggcgggatg actgccgcgg ggttgatttt
    41101 tcttctttcc taccggaaga acaaagatat ttccccccac aggattgatt ttaacgggtg
    41161 tagcgctggg aagcggttat ggtgcgctaa ctacactgct tactctgaaa ctggaccaaa
    41221 atcagatgga atttatacag cgttggagtg caggcagttt gtggggagat gactggcggt
    41281 atctggggat tttggtacca tggacagcca ttttgtgcgc atatgcatta tataaatccc
    41341 atgtgctgaa tattttaaac cttggaaatg aaaccgctac aggtctgggc actgcggtaa
    41401 agccggaatt tatcggcctg acggtggcgg cagtggcact ttcttctgga agtgtatctt
    41461 tgggaggcaa tttctttttt gtaggcatga ttgcccctca tatggcaaga aaaatcgttg
    41521 gatctaatca caaactgctt cttccagcgg ctgggctgtg cggggcgata atcgttctgc
    41581 tggcagatac gataacaaga accatcagcc tggggacgga tgtacctaca ggcattgtaa
    41641 ttacagtgct cagcacacca tactttttgt atctattggc aaaagcaaac aattaaggag
    41701 tacagtatga atagtattgc aacagaaaac ttagacattg cgtatgacaa tgcactgatt
    41761 gttgagaatt tagagatggc aatccctcgt aataaaatta cgtcaatcat cggcccgaac
    41821 ggatgcggaa aatcaacagt gctaaaggcg gtcgggcgta ttttgaagcc aaagaaaggc
    41881 atggtttatt taaatggcgg ggacatttcc actttaccca caaaagagat tgcaaagaaa
    41941 atgtccattt tacctcagac cccttcggca cctggtggat tgacggtaag tgaactggtt
    42001 gcctacggaa gatttcccca tcaaaatggc tttggaaagt taacaaagga agataaaaaa
    42061 atagtcgagt gggcaatttc cgcaacaaag ctttctgacc tggagcatcg ggaagtaaac
    42121 accttgtcag gcggtcagcg gcaaagagtc tggattgcca tggcacttgc ccagcagaca
    42181 gatttgattt tactggatga acctactaca tatctggata tggctcatca gctggaggtg
    42241 ctggagcttt tatacagctt aaaccgcaat cagggttgta ccattgcgat ggtacttcat
    42301 gatttaaact tagcggcgcg tttttctgat tatatgattg ccatccgcag tggaaaaatc
    42361 atacagcacg gatcgcctaa ggaagtaatg attcctgagg ttttaaagaa gactttctct
    42421 attgatgcag aagttgtgca tgaatccaga acaggaaggc cggtttgcct gacctattcg
    42481 ctgctgcatc aggaggactt accaaagagg gaggcgattt ctctatgaat atagcactgc
    42541 ggatattttg cgaggcaaaa aaatatcgga tctttctggt gtttgcattt ttagccctgg
    42601 ttgtatctac agtagccgga ttttatacgc cgtgggcatt aagagagtta acctctcttg
    42661 ccacagaagg aagtggagat tttggctcag aagccttacg catcggtttg cttttactgg
    42721 gggcggcaac gctgcaggcg gcgggtgcat cggctgcagg gtatatgaac cattatgcgg
    42781 cactgcatta tgtggctgat ttacgcaaaa tgctttatgg aaagctgcag aatatgagcc
    42841 tgagttattt ccacaaaagc agaactggcg accttaccag ccgggtggtg aatgatacat
    42901 tagatgcaga ggtgcttttg gctcatgtaa ttcctgattt tattgtgaat atccttactt
    42961 ttatcggggt cggtatcctg ttgtttacaa ttaatgtaaa actggctttt atgagcctgg
    43021 ttgccattcc gtttttatta ggtattactc tttggcaggg acatcacgta tcacccgtat
    43081 ggaaggaaaa ctcccgtgtg agaggagcgc ttgcgggcaa ggttcaggac aacctttcag
    43141 gaatgaaaga aatacagatt tttaatcagc agagtcatga agaaaacagt attgctcacc
    43201 ttgccatgct ccatagccgg gcctatcttc gtgccagttt cttttttgaa acatcatatc
    43261 ctttgctggc atttgtgact gcactgggca cggttattgt ggtgatttac ggcggacgtt
    43321 tagtaggaac gggagaggta aacattggcg acattgttgg cttcgccatg tatttatcta
    43381 tgttttatgg accagtgaaa aatttttccg ctcttgttga acgcgctgga gaggcgggtg
    43441 cagggtgtaa acgtgtattt gatgtgtttg atgaaatttc agaggtgaaa gaaaaagaga
    43501 atgccattgt tctgaagcgg gttaatggag aaatcgagct aagagattta accttctcct
    43561 atcatgaaga tattcctgtg atggaaaata ttaacttaaa aatccagacg ggacaaacag
    43621 tggcactggt tggaaccacg ggcgtgggca agagcaccat tgcaaacctg attaaccgtt
    43681 tttatgatcc tcaaaatggg gcggtttata ttgatggaat tgatattcgg gatgtaaccc
    43741 tttccagtct gcgcaataat atttctatgg tattacagga tactttctta tttaacggta
    43801 cagtgtatga gaatatagcc tatggctgga aaggtgccac gaaagaagat gtgcttgctg
    43861 cggcaaaagc tgccaatgcc catgatttta ttgaaaaaat ggaacatggt tacgacacta
    43921 ccattggaga aagaggtgtc ctgctttctg gggggcaaag acagagaatt gccattgcca
    43981 gagctatttt aagagattcc cccatcctga ttttagatga ggcaacctcc gccttagaca
    44041 ccaaaacaga aatggaaatt caggcggcgt taaacgagat atctaagacc cgtaccacca
    44101 ttatgattgc acacaggctt tctacaaccc gggatgcaga tttgattgtg gtactggatg
    44161 gaacaggtat tgcggaaatt ggcagccacg atgaactaat gaaaagaggc gggatatttg
    44221 caggcctgca tggtgtccat gcatgatgaa aggaatgtac tttatgttta aaaaagcaga
    44281 tgagcagtaa aattgtggca gtatctttta tgatactgct tctgctttcg ggctgtagcg
    44341 ctgacttgaa agatagtgat caggctgata aaagcagcac ggaatcaaca gatacaaggc
    44401 tgttctccac agacaaagga gagattgaaa ttcctgtgca tcctaaaagg gtgatttcgg
    44461 atttcggatt gctgggagat gttctagccc ttggtgtaat gcctgttgca attgaggatt
    44521 atggcgcaac agatgtggca ttcaaagact tgattaaaga tacaaaggtt ctggaaaaat
    44581 gggagccaga gtacctgatg gctgaaaacc cagatctgat tattacgaga aatgaagata
    44641 gttatgagca gctttcaaaa attgcgccaa cggtttacat acccgtctac gaacttgaaa
    44701 cgggagagag actttctttt ttatccgatg ccttaggctt gggacaggaa aaaggaagag
    44761 aagtggtgga taactatgaa acgaaggtaa aggaggcaaa ggataaatta aaaaataccg
    44821 gcttatacaa taaaactttt agtattatcc gtgtgcaggg cgaaaatgaa attggtgtgc
    44881 gttggagcaa taatctgggg ggacagattt tattcggtgc tttgggacta ccccagacag
    44941 aagctgcgtt aagagaggta aaagcaggcg ttgattgggg cgctacactt tcctttgagg
    45001 cagtgactga atatatggga gattacatac tggtaacaga atatggcaat tatcagttga
    45061 ttgaaaataa tcctgtgtgg aagtctcttt ctgcggtgca gaatgggaat attattgtgc
    45121 tttcagaacc gtatatgtat ttgaatgata tatattcctg gtcggcccaa ttggatttgg
    45181 ttacagggga acttctcaac ctggctgaaa aaaatggagt tcaaaaataa gtcttcctca
    45241 acaaacacag ataaaaggag ttaaatatgt ttagacaaat aaagaaaaaa acaattttta
    45301 tattagcgct ttctatgata tttgtgttat ctggatgcag taattcagca aaaacagagg
    45361 aaacaagtaa cgaagagtca gttcgtcgag agtctgattc cacaaaatcc aaaatcattc
    45421 atatggatta tggggatgtt gagataccgg agaatcccca aaatgtcatc gttactttca
    45481 atcaggggga tgtgattgca cttggtatca taccagtggg agctactttt agtgaaggat
    45541 cagcatttga ggaactggct gaaaatatta ctcaaattga tggctgggaa ataaatccgg
    45601 aggagttact gtctctaaaa cctgatttga taatttgggg aagctacgat gaaaaaagtt
    45661 atgaaacatt atctaaaatt gcaccaaccc tggccgggga tttttatagt atgagctatg
    45721 aagaacgact tcgttttttt ggagagatat ttaactgtga agaaaaagcg gaagttttaa
    45781 tacaaggttt taattctaaa ctgaaagaaa ctcaggcaaa attagataat gctggattat
    45841 taaacaagaa tatagcctgt attgaagtaa ttggtgatac ggttcgtgcc tatcagtttg
    45901 gacgaggagg cagtttggtt tataatatgc tgggactttc tgccccggag aagttaaatg
    45961 aagcatttaa agataagacg tcgattgata tttcctatga agtattacct gagtacatgg
    46021 gagattatat attgttaaat acgggaaaag acaagctggt tgacaataaa gtctgggaaa
    46081 atatttccgc cgtgaaagaa ggcagactaa ttcaggcatc atctaatatg ttttggttta
    46141 atgatattct atctttatcc aaacaaattg atattattgc aaatagtatg ttggaaaaat
    46201 aacattcttt ttaattgaat tatgaactag aaaaccgcat ccccttagaa aaggaatgcg
    46261 gtttttctgg ttatttccaa tccgaaagcc aggttttgtc atttgcaact gcggtaacta
    46321 cttcttcgcc ggatttaaaa ttatcaaaag ttcctttgtc aatttcgttt ataactttac
    46381 ttaacagttt ttcataatac gcttccggtg tgacctcggt tgttgtctga tggaaatgct
    46441 gctgggattc cgatgaggct attcttgcgt attcatcttt tacctgggct atcagtttat
    46501 catgattcat tttattttgc tcctctgttt aaatttggtc ttcaatacgt accaagtata
    46561 gaattattat tggcaggcaa ttggataata tactgaaaat ggtgaaaagt taaaatgaac
    46621 ccagctgcag actgaaagag aacaattgtg cagaagacag cttgacaata agcaaataat
    46681 atattatgtt atagacagac agtcggtcta taaggagggc aatctgatga gagtaataaa
    46741 agatgcagat caacgaaaaa atgaaatact ggatgcagct gaaacgttgt ttaccctgaa
    46801 ggggtttgac aaaacaagca caaatgaaat tctggaagca gtggggattg cccgtggaac
    46861 actgtattac cattttaaat caaaagagga tatcatggat gctttgattg aacggcatac
    46921 cagccgatta ctaaaggctg caaaggaaat cgcggaagac aaaggcaaac ctgtctatga
    46981 ccgtatcatt caatcagtca gggctctcaa gataaatcag agcggcaatg aagtacttga
    47041 gcatattcac aggccgcaga atgctctgat gcaccaaaaa gtacaaaaaa caattttaaa
    47101 tggattaccc cctattctta caggtatcat ccgtgaagga attgaggata atctgtttca
    47161 tacaccctac ccatatgaat gtgttgagat gctggtggtt tatgccagta cggtgtttga
    47221 tggagacatg ttagacatca atcagcagga atatgcttcc cgtgcgcagg cttttatttt
    47281 caatgtggaa cgtctgctgg gcgttgaaag cggtacctta tcatttgcat cacaaatttt
    47341 tgaagaagaa acggagggat aagatgaatc atacatcaaa accatttgga aagttcctgc
    47401 ttctttggtc tggagaactt atttcagcaa taggcggagg acttacctct tttggtttag
    47461 gcgtttatgt ttatcagcag tcaggaatgg catcacatgt atctttcgtc atgttgctgg
    47521 cttttctgcc ttccctgctg cttagtgcac ctgcaggggt actggctgac cattatgatc
    47581 gcaggattct gatgatactt ggagacagtc tttctgcaat cggccctttg tttattctc
//
