LOCUS       NZ_CP070896            21548 bp    DNA     circular CON 17-JUN-2024
DEFINITION  Lacrimispora xylanisolvens strain ASCUSBR21 chromosome, complete
            genome.
ACCESSION   NZ_CP070896
VERSION     NZ_CP070896.1
KEYWORDS    RefSeq.
SOURCE      Lacrimispora xylanisolvens
  ORGANISM  Lacrimispora xylanisolvens
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Lacrimispora.
REFERENCE   1  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Hungatella xylanolytica ASCUSBR21
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) R&D, Ascus Biosciences, 6450 Lusk Blvd E209,
            San Diego, CA 92121, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-MAY-2019
            Assembly Method                   :: Canu v. 2.1.1
            Assembly Name :: Hungatella xylanolytica ASCUSBR21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017084465.1-RS_2024_06_17
            Annotation Date                   :: 06/17/2024 10:45:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,443
            CDSs (total)                      :: 6,353
            Genes (coding)                    :: 5,667
            CDSs (with protein)               :: 5,667
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 686
            CDSs (without protein)            :: 686
            Pseudo Genes (ambiguous residues) :: 0 of 686
            Pseudo Genes (frameshifted)       :: 599 of 686
            Pseudo Genes (incomplete)         :: 95 of 686
            Pseudo Genes (internal stop)      :: 24 of 686
            Pseudo Genes (multiple problems)  :: 30 of 686
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:11:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 3821495
            Orig. end                         :: 3843043
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070896.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21548
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RRE-containing"
                     /region_number="7"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     cand_cluster    1..21548
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21548
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11548](+)"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11548
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     misc_feature    complement(30..43)
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.43"
                     /tool="antismash"
     misc_feature    156..169
                     /note="TFBS match to PsrA, Oleic acid responsive regulator,
                     confidence: weak, score: 19.97"
                     /tool="antismash"
     gene            241..393
                     /locus_tag="JWH23_RS21200"
     CDS             241..393
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS21200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277406093.1"
                     /transl_table=11
                     /translation="MDLSKESAYEKKWGEKQTAVLIERCYLGEASVKELVLSLLKKRLE
                     AGGRD"
     gene            386..916
                     /locus_tag="JWH23_RS21205"
     CDS             386..916
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012464.4"
                     /locus_tag="JWH23_RS21205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_277406094.1"
                     /transl_table=11
                     /translation="MIREREKEGRQYKAALYMRLSKDDGTGESASINTQRSMLRSYADR
                     NGFFIYGEYADDGYSGTTYDRPAWKRLLADIEAERVNLVITRDLSRLGRDYILTGQYTE
                     IYFPAKGVRYIAVNDGYDSNNRGNDLAPFQNIVNEMYARDTSKDSKRIKNQDGRRGIYR
                     KLCSLRISKGSWG"
     gene            880..2004
                     /locus_tag="JWH23_RS21210"
     CDS             880..2004
                     /GO_function="GO:0000150 - DNA strand exchange activity
                     [Evidence IEA]"
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0006310 - DNA recombination [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF019149.4"
                     /locus_tag="JWH23_RS21210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="recombinase family protein"
                     /protein_id="WP_277406095.1"
                     /transl_table=11
                     /translation="MLLTDIKRILGIKNHLLIDPLTAPVVRDIFKRASRGESPLKIAKL
                     LNERCIKTPASYRRFIRQEVGLETDEGEKGWTSSIICKILSNRVYTGDMVQGKTSKLSF
                     KSKMTLRIPKEEWIVVENKHNAIISRDLFEQAGRRSVPRKRSKSAQFYNAFSGLVYCGD
                     CKRVMTTTGGSHTEDRKLVCSGYKQYGRTACTNHYMKYDLLCQIVSQELETFITLSEEE
                     KKKVAGQLEYYGRNRGNSEEKRAAASLKKRERQIERIIGKLYEDRVNKVVEEERFCKLL
                     TSYEQELKEIGAEARAIKKITASVRKSADGPEEAVDRLLNELKGKRIPASDLLHQFIDR
                     IEIFQSRKDPDQKENEIITVRIFYRTESPDSKKA"
     misc_feature    complement(2007..2023)
                     /note="TFBS match to NtrC, Nitrogen regulatory protein C,
                     confidence: medium, score: 22.03"
                     /tool="antismash"
     gene            <2017..2862
                     /locus_tag="JWH23_RS21215"
                     /pseudo=""
     CDS             <2017..2862
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002592600.1"
                     /locus_tag="JWH23_RS21215"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="nucleoside recognition domain-containing protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MCMGFGCNAAGIVGCRIIDSPRERLIAMITNNFVPCNGRFPTMIA
                     IITMFFIGGATGSFSTILSAGILSGIILLGIFMTLVISKILSVTILKGIPSSFTLELPP
                     YRRPQIGKVIVRSIFDRTLFVLGRAAAVAAPAGLLIWLMANITVGDMTLLTRCSGFLDP
                     FARVIGLDGVILLAFILGFPANEIVVPIMIMAYLSEGSIREINDLSILRDLLISHGWTW
                     VTAVSTLLFSLMHWPCSTTCLTIRKETGSIKWTLLSWLVPTVTGVIVCFLFTTAARAFL
                     "
     gene            2927..3154
                     /locus_tag="JWH23_RS21220"
     CDS             2927..3154
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002601263.1"
                     /locus_tag="JWH23_RS21220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="hypothetical protein"
                     /protein_id="WP_277406096.1"
                     /transl_table=11
                     /translation="MNRSYHVYALSDRPKARKIEREIAKVDGVKVIKISEDLKLMNIEM
                     ENSKITAVMERVVNICNRISNGCEVHYKFT"
     gene            complement(3207..3605)
                     /locus_tag="JWH23_RS21225"
     CDS             complement(3207..3605)
                     /GO_function="GO:0046872 - metal ion binding [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014116494.1"
                     /locus_tag="JWH23_RS21225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="bacteriohemerythrin"
                     /protein_id="WP_104438171.1"
                     /transl_table=11
                     /translation="MPWTQNLSVGISMIDDQHKMWFEKAEALFDAGKNNKAKEYVGELL
                     DFLESYTKKHFADEEVYMQKIHYPGYAEQKQAHTAFIAQLTKLRSDYNSSGGNLLVILN
                     ANQMVLEWLTKHISNMDKKIGEYAKTAH"
     misc_feature    3627..3642
                     /note="TFBS match to FuR_variant_1, Ferric Uptake
                     Regulator, confidence: weak, score: 23.51"
                     /tool="antismash"
     gene            3784..4560
                     /locus_tag="JWH23_RS21230"
     CDS             3784..4560
                     /GO_function="GO:0003723 - RNA binding [Evidence IEA]"
                     /GO_function="GO:0009982 - pseudouridine synthase activity
                     [Evidence IEA]"
                     /GO_function="GO:0016866 - intramolecular transferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0001522 - pseudouridine synthesis [Evidence
                     IEA]"
                     /GO_process="GO:0009451 - RNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1154: Pseudouridine synthase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008395533.1"
                     /locus_tag="JWH23_RS21230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="pseudouridine synthase"
                     /protein_id="WP_277406097.1"
                     /transl_table=11
                     /translation="MDANGIRLNKYLSEAGICSRREADRLIETGKVKIDGQAAVPGQKV
                     LPGQSVTVKGRSVSAAKGETGHKAEPVFLAVHKPRGVVCTTSDKDRAPNIVDLVHYPVR
                     IYPIGRLDKESEGLILMTNQGDLVNKIMRSGNAHEKEYLVKVNRPVTDDFIRKMRKGVT
                     LSELDVTTKPCFAEKAGEKTFRIVLTQGLNRQIRRMCTQLGFEVRMLKRMRIMNIELGD
                     LKPGAYRELSRREYHQMKESLKLDQSSLSRTEKGEI"
     gene            4560..6518
                     /gene="ligA"
                     /locus_tag="JWH23_RS21235"
                     /pseudo=""
     CDS             4560..6518
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0003911 - DNA ligase (NAD+) activity
                     [Evidence IEA]"
                     /GO_process="GO:0006260 - DNA replication [Evidence IEA]"
                     /GO_process="GO:0006281 - DNA repair [Evidence IEA]"
                     /codon_start=1
                     /gene="ligA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006782077.1"
                     /locus_tag="JWH23_RS21235"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="NAD-dependent DNA ligase LigA"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDEKLKRIKELIPLLQEAGKAYYQESREIMSNYEYDRLYDELAAL
                     EEETGVVLSNSPTQNVGYQVLSELPKEAHDSPMLSLDKTKSTEDLADWLGGQRGILSWK
                     LDGLTVVLVYREGTLQKAVTRGNGEIGEVITNNARVFANIPLTISYQGELVIRGEAVIK
                     YTDFNRINGEIEDVTAKYKNPRNLCSGSVRQLNNQITARRNVNFEAFALVSAPGVDFKK
                     LQS"
     gene            6522..7427
                     /gene="metA"
                     /locus_tag="JWH23_RS21240"
     CDS             6522..7427
                     /EC_number="2.3.1.46"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008899 - homoserine O-succinyltransferase
                     activity [Evidence IEA]"
                     /GO_process="GO:0019281 - L-methionine biosynthetic process
                     from homoserine via O-succinyl-L-homoserine and
                     cystathionine [Evidence IEA]"
                     /codon_start=1
                     /gene="metA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008703328.1"
                     /locus_tag="JWH23_RS21240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="homoserine O-succinyltransferase"
                     /protein_id="WP_277406098.1"
                     /transl_table=11
                     /translation="MPIKVQKDLPAKAILETENIFIMDEDRASRQDIRPLEILIINLMP
                     IKEETETQLLRALSNTPLQVDCTFLMLESHTSKNTSASHLNKFYVFFNEVKEKKFDGMI
                     ITGAPVENMEFEEVNYWEELTKIMEWSKTNVTSSLHICWGAQAGLYYHYGVPKYKRDTK
                     LSGIYRHRVLDRKVPLVRSLDDFVMAPHSRYTEVRRADIEKHQELRILAESKEAGILMV
                     MSEDGKQVFIQGHPEYDRMTLNGEYHRDLDKGLNPDIPCNYYEDDDPDTMPVLCWRNAA
                     NTIYGNWLNYYVYQVTPYEL"
     gene            complement(7956..8675)
                     /locus_tag="JWH23_RS21245"
     CDS             complement(7956..8675)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF017390.4"
                     /locus_tag="JWH23_RS21245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="M56 family metallopeptidase"
                     /protein_id="WP_277409941.1"
                     /transl_table=11
                     /translation="MSFQIIIVDFITTPMLYGIHAPKILIPVMELSEKDWSFILSHEVE
                     HYYRKDLYIKLLIEIITIAYWWNPFIYLLKTAFDKVLEINVDLSVTKDLDPEEKLEYLQ
                     CLLDTARKFSPKKLYGLSLAFESRNKSILAQRFYMVLESENSKKSSKTILMIMPIIFIS
                     IFSLLVVFEPYAISPTDAQSTFELDADNAYLIVNPNRDYDLYINQKYIATVHEIKSSYS
                     NLSIYQNLKEANAHEIK"
     misc_feature    complement(9378..9396)
                     /note="TFBS match to FuR_variant_2, Ferric Uptake
                     Regulator, confidence: weak, score: 23.4"
                     /tool="antismash"
     gene            10001..11548
                     /locus_tag="JWH23_RS21250"
     CDS             10001..11548
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF035951.1"
                     /locus_tag="JWH23_RS21250"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="RumMC family radical SAM sactipeptide maturase"
                     /protein_id="WP_277406099.1"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     8.8e-13, bitscore: 47.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 8.9e-55, bitscore:
                     184.7, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.3e-13, bitscore: 50.2,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1e-08, bitscore: 34.1,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEESYLKLQKYLEELIPSKYYERLGAVFRTKRNMYVYDTGTGKVF
                     SCNEIEYRIFESIFNNFDLMKEKLKNYQEEDIIHAIDSIIEVIKTENILQATDYKEFAR
                     ETDQELNAVLNYSLQSLILEVTQKCNFRCKYCIYHDYNSLYRDYTAKDMSWETAKKTID
                     YVKAHCGEKDLSIAFYGGEPLINYDLIHDVIGYCKQIMSDKSLIFSFTTNLSLMDKNKA
                     AFFAKEGCYIMCSIDGPSIIHDAYRVDAEGNGTFELVMQGLKNLIEAYGNDAEEKISFN
                     VVICPPYIKDKFDAIKDFFSQIEWLPPKLTIKYSYVESGSLREEDIDYTYFSKDERKNQ
                     VSEIAPVAEWTMNKLIDKSDTDYLPYSFARDALVRVHKRFLSDRPYEKMKRNGCCIPGG
                     RRIYVDVDGNIALCERVGKCPPIGNIDTGIDINKIKKYYLEDYEKKSLDKCKNCWAVNL
                     CNICYAACYREDGIDISSKNELCYIQRKQIKGELILYYEVMEEAPDVLANFEEIEVF"
     aSDomain        10058..10306
                     /aSDomain="Other_Sactipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a sactipeptide
                     cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JWH23_RS21250_Other_Sactipeptide_rSAM
                     _RRE.1"
                     /evalue="3.90E-15"
                     /identifier="RREFam021.1"
                     /label="JWH23_RS21250"
                     /locus_tag="JWH23_RS21250"
                     /protein_end="102"
                     /protein_start="19"
                     /score="47.0"
                     /tool="antismash"
                     /translation="YYERLGAVFRTKRNMYVYDTGTGKVFSCNEIEYRIFESIFNNFDL
                     MKEKLKNYQEEDIIHAIDSIIEVIKTENILQATDYKEF"
     misc_feature    complement(11552..11565)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 25.44"
                     /tool="antismash"
     misc_feature    11553..11566
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     strong, score: 28.14"
                     /tool="antismash"
     misc_feature    11561..11577
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.53"
                     /tool="antismash"
     gene            11603..11809
                     /locus_tag="JWH23_RS21255"
     CDS             11603..11809
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016214182.1"
                     /locus_tag="JWH23_RS21255"
                     /note="This RiPP (ribosomally translated,
                     post-translationally modified peptide natural product), in
                     the ruminococcin C family, is modified by a radical
                     SAM/SPASM domain protein to have several cross-bridges from
                     Cys sulfur atoms to alpha carbons of another amino acids.
                     It is therefore defined as a sactipeptide.; This RiPP
                     (ribosomally translated, post-translationally modified
                     peptide natural product), in the ruminococcin C family, is
                     modified by a radical SAM/SPASM domain protein to have
                     several cross-bridges from Cys sulfur atoms to alpha
                     carbons of another amino acids. It is therefore defined as
                     a sactipeptide; Derived by automated computational analysis
                     using gene prediction method: Protein Homology."
                     /product="RumC family sactipeptide"
                     /protein_id="WP_277406100.1"
                     /transl_table=11
                     /translation="MKLVNPLGREIEKLNSQADYVSPLSGCVCSGPTGTAVSHNKGPGW
                     CVGYCGGESSETRNANAELARYA"
     misc_feature    complement(11644..11664)
                     /note="TFBS match to NrtR, NAD synthesis repressor,
                     confidence: weak, score: 24.21"
                     /tool="antismash"
     gene            11873..12244
                     /locus_tag="JWH23_RS21260"
     CDS             11873..12244
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS21260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277406101.1"
                     /transl_table=11
                     /translation="MEMKGRISPSEYIKTIIKVLELLFRSSKLYTSLILIVNIFIGIIV
                     PINVIIWKNFINSAVAGISDRSWQTAIFWISIYSLIYILDNILSKINEFIENILASKVN
                     IFTTKLILDRLVDIPMEFF"
     misc_feature    12365..12381
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 24.82"
                     /tool="antismash"
     gene            13017..13688
                     /locus_tag="JWH23_RS21265"
     CDS             13017..13688
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012235.4"
                     /locus_tag="JWH23_RS21265"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ATP-binding cassette domain-containing protein"
                     /protein_id="WP_277406102.1"
                     /transl_table=11
                     /translation="MQKKSYSIVGLNGSGKTTLIKLMLNLYEPDKGEVLIDGVNIREFN
                     KKEYVKNIGVVFQDFIKYPLTVSENIGIGDPENIDNFNQVETAAVLSGANEFIRNLPDK
                     YETKLLREWSGGIQLSLGQWQKLAISRAFMKKYPIIILDEPTASLDAIAEFELYKKFKQ
                     MVSGKTCILIAHRFSTIKLADTILVLKDGEIVETGSHEELIKKQGDYAELYDLQAQTYK
                     E"
     gene            13699..14055
                     /locus_tag="JWH23_RS21270"
     CDS             13699..14055
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M16"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF012879.4"
                     /locus_tag="JWH23_RS21270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="insulinase family protein"
                     /protein_id="WP_277406103.1"
                     /sec_met_domain="Peptidase_M16 (E-value: 7.8e-09, bitscore:
                     34.2, seeds: 24, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTYLCINNKRIPCYLNKVDFNTDILACALVVKSGSLQDEIPGTA
                     HILEHVMIENQVIKNWDWDTIDRRAHTDFYETTYYFKTNKNIFNIGLEFIESIVDGLWL
                     NEENFELVKKEYCR"
     misc_feature    complement(14502..14515)
                     /note="TFBS match to ArgR, Regulator of arginine
                     biosynthesis genes, confidence: weak, score: 17.68"
                     /tool="antismash"
     gene            14989..15654
                     /locus_tag="JWH23_RS21275"
     CDS             14989..15654
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002604241.1"
                     /locus_tag="JWH23_RS21275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /protein_id="WP_277406104.1"
                     /transl_table=11
                     /translation="MFKILVIEDDKDISELLKFFLEDNGYSVRIADNGIEGIEIYRHES
                     IDLILLDILLPKVDGYMVCKTIRKESDIPVIMITALTSEDEQIRGYDLQVDDYVTKPFS
                     MPVLLKKVAAVLRRINGDQEKNILFYKDLVLDTDNYRVSIKERTIDLTKKEFEILRELL
                     MNQNKILTRELLLGRVWKYEYFGNDRIVDNHIKNIRKKLGVDYIETIKGVGYRIDKVN"
     gene            15608..16054
                     /locus_tag="JWH23_RS21280"
     CDS             15608..16054
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS21280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277406105.1"
                     /transl_table=11
                     /translation="MKQLRESAIELIRLIRSKLLIKVFLLTLIVLWGLTGLTYTFILIV
                     TPRLYQTELQRNLDTAIERTIKELSSVNLKRGKEIIKDLSNSYNIAIMLFDSNGKQIDY
                     GEDILFVADGNTASVLERKSITQTYEVNFNDIQEIYTMTVLGKK"
     gene            16159..16752
                     /locus_tag="JWH23_RS21285"
     CDS             16159..16752
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012722.4"
                     /locus_tag="JWH23_RS21285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase dimerization/phospho-acceptor
                     domain-containing protein"
                     /protein_id="WP_277409942.1"
                     /transl_table=11
                     /translation="MTMPIKNISSYSRKLAELNFTSHYFNNRIDEIGNLAENLNELSEH
                     LNNALDELRTANDSLKKEIEYEKKVEQQQMTLFSALSHELKTPITILKGQTQGMLYNVG
                     GYKDRDKYLKRSFEVICMMEQLVKEILIASHIQSSMYKIKTENINLSEELYDIIKEYDE
                     MILLKKKVNIQIKLMDFSIIFADRNLIKKKYLVI"
     gene            17306..17806
                     /locus_tag="JWH23_RS21290"
     CDS             17306..17806
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS21290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277406106.1"
                     /transl_table=11
                     /translation="MKVSKNMLLIMTFAVLTLGGCSQKEDTNTPPNSISEDNQIKTEKI
                     NETENIPSLDEAVNSGIVTELSDLRFEILPMTVDEDELDMPVGEEAQSGVKKINVNYSS
                     EVKVKIIEYDTATNKNNYLDSDINDIKKDSVVYIYGEYVNETEIKADQIIIFRVKKKII
                     LSN"
     gene            17862..19049
                     /locus_tag="JWH23_RS21295"
     CDS             17862..19049
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="JWH23_RS21295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_277406107.1"
                     /transl_table=11
                     /translation="MEKKKGKSFILLFIFIIINCMNISMLSILRVTKEAELEIKKNTQA
                     KITLEVKENDNLITKTELEKILAVGNIIDVNRVCKDYAIPHNFKNYKGKIEDDIRDNMV
                     TLYGYDDLSQDSRFSELEMKITSGETVKPMSQDSVVINHNLAELNSLQIGDIIEFSKND
                     RTISGKICGIYKSSIEDKQRENITSFFRIENMVFLSQTLMEQLVNEGNYNKVVLYVQDP
                     EKLEDTVDKVKSLLGEKIEVSTTDTMYEKLKMNLDQIEKITNVILILVVIISVIVITLI
                     YGIWIRDRKKEIAILLSLGKSKVSVFLQICLESFMLFGCSVILAVLVGNIITTWIERAL
                     LTWQDSRIGLNINLNVYDIVKVIAIGSLVLIISISLSLVRIIMAKPREVLAEMEG"
     gene            19051..20298
                     /locus_tag="JWH23_RS21300"
     CDS             19051..20298
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014717.4"
                     /locus_tag="JWH23_RS21300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter permease"
                     /protein_id="WP_277406108.1"
                     /transl_table=11
                     /translation="MNVVKRGLYSVLRKKVKSILLFIIVLSISCFIMAAMASKNAQVTT
                     QDKSRAVVGLSLRLELNENDRRERLLEIPVEKLPNGATISRSPNNEFESVLMDDILKIS
                     KVEGVKSYNIITGVFAANPVNFKRIEDPDRDQYNDEGGVNLHGNLDMAQDINILNGNIK
                     LIEGRWGTEADHNVCVVSKEIAEKNKIKIGDLLEFNNYRDKEGSTIYKAELIGIYSTAK
                     EITPLMRGDTYRTENAVFTDLRFPEKPIGAEGDPLYQYAIFNLDGNKDYDTIKENVKKA
                     DVNWKRYDLIDNSGKSEVLADNLGQLGKISNVMFAICIISGFLILFLNFIFWIRLRKVE
                     IGILMALGKSKLEILAQLIIEASFITLFSLLTSLFISPSISQKLTTYIVAEQEEQQNKI
                     DGINKAQTAGLEYDFR"
     misc_feature    20332..20345
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     medium, score: 25.52"
                     /tool="antismash"
     gene            20462..21109
                     /locus_tag="JWH23_RS21305"
     CDS             20462..21109
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008790772.1"
                     /locus_tag="JWH23_RS21305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_277406109.1"
                     /transl_table=11
                     /translation="MILELKNVDYYYKANKSKKILSDINIGFEEGKMYAVLGPSGSGKT
                     TFLSLLAGLDIPVKGEILYDGENILKNGLNFHRKNNVSLVFQNYNLIDYLTPKENVRLG
                     GDGEPEKLLSEVGITKEEGKRNVLQLSGGQQQRVAIARALASNSKVLLADEPTGNLDEQ
                     TAYEIVTLLKKSAHMIGKCVIVVTHSKELAKQADEVIKIKNGNIELVNYEED"
     misc_feature    21414..21430
                     /note="TFBS match to RicR, Copper-responsive regulator,
                     confidence: weak, score: 21.14"
                     /tool="antismash"
     misc_feature    complement(21415..21430)
                     /note="TFBS match to CsoR, Copper-responsive repressor,
                     confidence: weak, score: 21.84"
                     /tool="antismash"
ORIGIN
        1 agcttttaat atttaagagt gcaagttgct ttttgtttaa aatagtaaaa tttgcacaaa
       61 aatattattt tggtttagag gggtttagaa caatgtgcat aaaagttttg gaaaaatcaa
      121 ccttttaaag aagctgaaat aaacacctct aaatgcaaac ggcagtttta ctacgagtca
      181 gcttcactta tgtatatggt acaaaccttt atgaataaga tttttcagga ggtgggcatc
      241 atggatttgt ccaaagagag cgcctatgaa aaaaaatggg gagaaaagca gaccgcggtt
      301 ttgattgagc gttgttatct aggagaggca tccgtaaagg aattggttct cagtctgtta
      361 aagaaaaggc tggaggcagg aggtcgtgat tagagagaga gagaaagagg ggcggcagta
      421 taaggcggct ttgtatatgc ggctctccaa agacgatggg actggagaga gcgcaagcat
      481 taatactcag cggagcatgc tgcgttccta tgccgaccga aatggttttt ttatatacgg
      541 agaatacgca gatgatggct acagcgggac tacgtatgac cgaccggcat ggaaacgcct
      601 gcttgcagat atagaagcgg agagggtaaa tcttgtaatc accagagacc tctccaggct
      661 tggaagggat tacatactta caggtcagta cacagagatt tattttccag ccaaaggggt
      721 tcgttatatt gcagtcaatg acggctatga ttcaaacaat cggggaaatg atctcgcgcc
      781 ttttcagaat atcgttaatg aaatgtatgc cagagataca tcaaaagatt cgaagcgcat
      841 taagaaccaa gatggaagac ggggcatata tcggaaatta tgctccttac ggatatcaaa
      901 aggatcctgg ggataaaaaa ccatctatta atcgatcccc tgaccgcgcc tgtggtgcgg
      961 gatatcttta agcgggcttc caggggagaa tctccattaa agattgcaaa gctgctgaat
     1021 gagaggtgta ttaaaactcc ggccagttat cgtcgtttta tacggcagga ggtgggcctg
     1081 gagactgatg aaggagaaaa aggctggacc tccagcatca tctgcaaaat tctatccaac
     1141 cgggtttata caggggatat ggtgcagggc aaaacctcca agctgtcatt taaaagtaag
     1201 atgaccttac ggataccgaa agaggaatgg atcgtggtgg aaaacaagca taacgccatt
     1261 atatccagag atttgtttga gcaggcagga aggcggagtg tcccacggaa aagatcaaaa
     1321 tcagctcaat tctataatgc attttccgga ctggtgtact gcggggactg caaaagagtg
     1381 atgaccacaa ccgggggcag ccatacggag gacagaaaac tggtatgcag cggatacaag
     1441 cagtatggaa gaaccgcatg caccaaccac tacatgaaat atgatctgct ctgccagatt
     1501 gtatcccagg agcttgagac tttcattacc ctgtcagaag aagagaaaaa aaaggttgcg
     1561 ggtcagttag agtactatgg aagaaacaga ggcaattcag aagaaaaacg ggcggctgca
     1621 tctttaaaaa agagggagag gcagattgag cgaattattg gaaagcttta cgaagatcga
     1681 gtcaataaag tggtggaaga ggagcgtttc tgtaagctgc tcacttctta tgaacaggag
     1741 ttaaaggaga ttggggcgga agcaagagcc ataaaaaaaa tcacagcatc tgtacggaaa
     1801 agcgcagatg gaccagagga ggctgtggac cgtttattaa acgagttaaa gggaaaaaga
     1861 attcctgctt ccgatttgct gcaccagttt attgatcgga ttgaaatctt tcagtcaagg
     1921 aaagatccgg atcagaaaga aaatgagatt ataaccgtca ggatatttta ccggacagag
     1981 tcaccagaca gtaaaaaagc atagattgcc cctgtcatgt gcatgggatt tggctgtaat
     2041 gcagcgggaa ttgtaggctg ccggattatt gattctccaa gagagcggct cattgccatg
     2101 atcaccaaca actttgttcc ctgcaacggg cgttttccaa ccatgattgc gattattacc
     2161 atgtttttta tcggaggagc gacaggatca ttttccacta ttttatctgc aggaattctg
     2221 tcaggtatta ttcttcttgg aattttcatg acccttgtaa tatccaaaat tctctctgta
     2281 accatattaa aggggatccc ctcttccttt accttagagc tgccccctta ccgcagaccc
     2341 cagattggaa aggtcattgt ccgttccata tttgaccgga ccctctttgt tctgggaaga
     2401 gcggctgcag tggctgcacc cgcaggtctg ttaatctggc tgatggcgaa tatcacagtg
     2461 ggggatatga ccttattaac ccgctgctcc ggttttttag atccctttgc cagagtcatc
     2521 ggccttgacg gcgtgatcct cctggcattc atccttggct ttcctgccaa tgagatcgtt
     2581 gttcccatta tgattatggc ttatctttct gaaggcagca tacgggaaat caatgattta
     2641 tccatattaa gggatctgtt gatttcccat ggctggacct gggtgactgc cgtcagcacc
     2701 ctgcttttct ccctcatgca ctggccctgt tccaccacct gcctgaccat aaggaaggag
     2761 accgggagca taaaatggac ccttttgtcc tggcttgtgc ctacggtaac cggagttatt
     2821 gtctgctttt tgtttacgac tgcagcaagg gcgttcctgt aatgtttaaa gttccctctg
     2881 tttgtctaca ataggggtaa gacactcata gaaaggaggg agaagcgtga acaggagtta
     2941 ccacgtttac gccctgtcag accggccaaa ggccagaaaa attgagcggg aaattgcaaa
     3001 ggtcgatggg gtgaaggtaa taaagatctc ggaagactta aagctaatga acattgagat
     3061 ggagaacagc aagattacgg ctgtcatgga gcgggtggta aatatctgca accgcatttc
     3121 taacggctgt gaagtgcatt ataagtttac gtaagaataa taagaaagag ggcttgaatg
     3181 gatttcattt aagtcctctt tgcccattaa tgggcggtct ttgcgtattc gccgatcttt
     3241 ttgtccatat ttgaaatgtg ctttgtcagc cattcaagca ccatctggtt tgcatttaaa
     3301 ataacaagta aattaccgcc tgaagaatta taatcgcttc taagcttggt aagctgggca
     3361 atgaaagcag tatgagcctg cttctgctct gcatatccgg ggtaatgaat cttctgcatg
     3421 taaacttcct cgtctgcgaa atgctttttt gtgtaacttt ccaggaaatc taaaagctct
     3481 cctacatatt cctttgcttt gttgttcttt ccggcatcaa agagagcctc tgctttttca
     3541 aaccacatct tatgctgatc atcaatcatt gaaataccaa ctgataaatt ttgtgtccac
     3601 ggcataacga aatcctccta tgtaataatg atatttatta ttataatacg cttgttaaga
     3661 aaaagcaaac catattttac cattcaggaa ataaaaatag attttaaaat agagataaaa
     3721 atttgacgta caactttagc aatgttataa tttttatcta gcaaatagta agggagaaca
     3781 attatggatg caaatggaat ccgtctgaat aaatatttaa gtgaggcagg aatctgttcc
     3841 cgcagggagg cggatcggct cattgagaca ggaaaggtta aaatagatgg acaggccgca
     3901 gtaccgggac aaaaggtgct tccagggcag tctgtaacgg tgaaaggccg ttctgtcagc
     3961 gcagccaaag gtgaaaccgg ccataaggca gagcctgtct ttttagcagt ccataagccc
     4021 cggggtgtgg tatgcaccac ctcagataag gaccgggctc ccaacatcgt ggatctggtt
     4081 cattatcccg tgcggattta tcccataggc cgtctggaca aggagtccga gggtctgatt
     4141 ctcatgacca accagggaga tttagtgaat aaaatcatgc gcagcggaaa tgctcatgaa
     4201 aaggaatatt tagtaaaagt gaatcgtccg gtcacagacg atttcatcag aaagatgcga
     4261 aagggagtca ctctttccga gttagacgta accacaaagc catgctttgc agagaaagcg
     4321 ggagagaaaa catttcgtat cgtattaacc cagggattaa accgccagat tcgccgaatg
     4381 tgcacccagc ttggttttga agtgcgcatg ttaaagcgaa tgcggattat gaatattgaa
     4441 ctaggagatt taaagccggg cgcttaccgt gaactttccc ggcgtgaata ccaccagatg
     4501 aaagagtcat taaagctcga ccagtcttcc ctatcaagaa cagaaaaagg agaaatctga
     4561 tggacgaaaa actaaaaaga attaaggaac tgatcccgct actgcaggaa gcaggaaaag
     4621 cctactacca ggaaagccgg gagatcatga gcaattatga gtatgatcgt ctctatgatg
     4681 aactggcggc gctggaggag gaaaccggag ttgttttatc taacagcccc acacaaaacg
     4741 ttggctatca ggtcttaagc gagcttccca aggaagccca tgattcccct atgctgtctc
     4801 tggataagac gaagagtacg gaggatttag ctgactggct gggaggccag agggggattc
     4861 tctcatggaa gctggacgga ctgacggttg ttctggttta ccgggagggt acgctacaaa
     4921 aagcggtaac acggggaaat ggagagatcg gagaagtaat taccaacaat gccagggtat
     4981 ttgcaaacat tccccttacc atatcctacc agggagaact ggtgataagg ggagaggcag
     5041 tcataaaata tactgacttt aaccggatta acggcgagat tgaggatgtg accgcaaagt
     5101 ataagaatcc aaggaatcta tgcagcggtt ccgtcagaca gttaaacaac cagattaccg
     5161 cccgccgaaa cgtaaatttc gaggcatttg ctctggtttc cgccccaggt gttgatttta
     5221 aaaaactcca gagctgagca gttccagtgg ctgagagccc agggctttga tgtggtggat
     5281 tataaaattg tgacgaaaga taccatcggg gaagcagttg ccgaatttgc aaagactgta
     5341 ccggaatacg acattccatc agatggactg gtgcttttat atgatgatat cgcttatgga
     5401 gaatctcttg gacggactgc aaagttcccc cgcaacgcca tcgcatttaa atgggctgac
     5461 gagatccggg aaactacgct gacagagatt gaatggagtg catcaagaac cggtttgatt
     5521 aatccggttg ccatttttga tccggtggag ttagagggta caactgtgag ccgtgccagc
     5581 gttcataatc ttagtattat ggaagctttg gagcttggag aaggagatca aatcacggtt
     5641 tacaaggcga atatgattat tcctcagatt gccgataatt taaccagaag tggtaaaata
     5701 aaaattccgg atcattgccc ggtctgtgac ggcattacgg agatacgtca ggtaaatgat
     5761 gtgaaaagtt tatattgcac caacccggat tgtcaggcaa aacggatcaa gggcttttct
     5821 ctgtttgtaa gccgggatgc tttaaatatt gatggattat cagaagctac gctggagaag
     5881 tttatcggag ccggatttat ccgggagttt gctgatatgt ttcatttaga tcagtatgag
     5941 gaagcgatta ctcagatgga gggctttggt aaaaagtctt atgacaattt aattcaggca
     6001 gtgaaaaagg cttctcatac gaccttacct cgtctgattt atgggcttgg aattgctggt
     6061 atcggagttg ccaatgcaaa gatgctctgc cgggaattcc gttatgattt cgaccgaatg
     6121 cgtcatgcag aggaagagga gctgactgct gtctccggca ttggaaaggt gctggcagat
     6181 gcatggatta cttattttaa ggacgagaag aataacgaga tgacagatcg tctgttagaa
     6241 gaagtaacca ttgagcagga ggcggagacc gcaggagaga agcggctgga gggaatgacg
     6301 tttgttatta ccggatccgt ggagcgtttt gagaaccgga aggcacttca ggaagcaatt
     6361 gaggcacagg gaggcaaagc tactggttct gttacatcga agacaactta tttaattaac
     6421 aacgatacca catccaattc atcaaaaata aaaaggcaaa ggaactggga gtgcccatta
     6481 tttcagaaga ggatttcata aaactgctgg agggataaaa tatgccgatt aaagtacaaa
     6541 aggatttacc tgcgaaagcc atactggaaa cagagaacat atttatcatg gacgaggacc
     6601 gggcctcaag acaggacatt cgtccccttg aaatcctgat tattaattta atgcccatta
     6661 aggaagaaac ggaaacccag cttctgcgcg cattgtctaa tactccgctg caggtggact
     6721 gtacgttttt gatgctggag agtcatactt caaagaatac ttccgccagt catttaaata
     6781 agttttatgt gttctttaat gaggtaaaag agaaaaagtt cgatggtatg attattaccg
     6841 gtgcgcctgt tgagaatatg gagtttgaag aggtgaacta ctgggaagag ctgacgaaga
     6901 ttatggagtg gagcaagacc aatgttacca gttcccttca tatctgctgg ggcgcccagg
     6961 cggggcttta ttatcattat ggagtgccga agtataagag ggatacgaag ctttctggta
     7021 tttacagaca tagagttctg gatcggaagg tgcctctggt acgcagtctt gatgattttg
     7081 tgatggcgcc tcattcacgg tatacagagg tgaggagagc ggatatagag aagcatcagg
     7141 agttgaggat tttagcagag tcgaaggaag ctggaatcct gatggtgatg agtgaggatg
     7201 ggaagcaggt tttcattcag gggcatccgg aatatgatcg gatgacgttg aatggggagt
     7261 atcataggga tttggataag gggttgaatc cggacattcc ctgtaattat tatgaggacg
     7321 atgacccgga tacgatgccg gtattgtgct ggaggaatgc ggcgaatacg atatatggga
     7381 attggttgaa ttattatgtg tatcaggtaa cgccatacga gttgtaggga agggcgcgga
     7441 aagattagat atatagaaat agcattcagg ctgagcttgg atgctatttg cgagcccaaa
     7501 gaccaagtct tagaagcaga aaaaattagt tcggataatc attatgggat ggtagttata
     7561 taaaggaaat attttcgagg catctatgta gcaagaaggc gtagccagac aggacatgtg
     7621 agataattaa gcgcgagtta caatttgtga gttattgaca gtcctgccat tcattctaag
     7681 cccaggttct ctcatataaa acgttgtatt aatgagattt ttttaacata actcccattc
     7741 accaatccat ttttgtttgg aatagttata ttggcgtcta tataaactat tacctacagt
     7801 tttataacgc cagccaatga tatcagaatc aggtacaaag attgggtcag cttgttccat
     7861 ggtagtaata tttgcggggg gaagatgcta atacctctgt tgggaataat agtaatccag
     7921 ttgtcaatgc cattaacgat aatgatagtt tcttcttact taatttcatg tgcgtttgcc
     7981 tcctttaaat tttgatatat tgaaagattt gaataagaac ttttgatttc atgaacagta
     8041 gctatgtact tctgatttat gtacaagtca tagtccctat taggattaac tattaagtaa
     8101 gcattatctg catctaattc aaatgtggac tgtgcgtctg ttggagatat agcatatggt
     8161 tcaaaaacta ctaataatga aaatatgctt ataaaaatta ttggcattat cattaaaatg
     8221 gtttttgaag actttttcga attttcactt tccagtacca tataaaatct ttgggcaaga
     8281 attgatttat ttcgactttc aaaagccaat gataatccat acaatttttt gggggaaaat
     8341 ttccgggcag tatctaacaa acattggaga tattccagtt tttcttcagg atctaaatct
     8401 tttgtaacag ataaatcaac gtttatctca agcactttat caaatgctgt cttaagcaga
     8461 tatataaatg gattccacca atatgctata gttataattt caattaataa tttaatatat
     8521 aaatctttac gataatagtg ctcaacttca tggcttaata taaaactcca atccttttca
     8581 gataattcca taacaggaat taatattttg ggagcatgaa tgccataaag cataggtgta
     8641 gtgataaaat cgactataat aatttgaaat gaaattttct tattatattt tgaataactt
     8701 tatctagggt gtttagtact ttttttgtct tctagtaaga tttgatgttt aatttcattt
     8761 ccaaacttta gatattttat tattgtcctt atagttaata caattattcc tagtatccat
     8821 attgcattta ttatatttat ccaagtaaaa tttatatttc ttattgtgat aatagaactg
     8881 ttcgaaaatt taaaaagctt aggtaataaa tattggacag gaattgaata agaaaatata
     8941 aattccatag gtattagtaa tctaaaaaca atataaataa cacatgcaat cactacacca
     9001 gttccgagta ttcttattct ttttacgctt tttaaataaa accataatat tataattagt
     9061 atattgcatg taaaaactat agtgaagaat tctgacgatg ataaaagcac atcactcctc
     9121 ctcctttatt tttttttatg aagaagtgcc cttcgttctt gtaataattc ttctagttct
     9181 ttaagtactt tttcctcttt tttttcatgt tgtaaaagtg tagcaactat gctggttgtg
     9241 gtcatgtttt tatctatatt tttaaattga ctaattatat tgagattcat taactcttgt
     9301 ttgcttaaca acggacgata actgcgtgag agaacagtgc cgctataaac tatttcagca
     9361 atttcaatta tatctttttt tagaaggttt cgcaatgata attggacaga gctaatgctt
     9421 agactgggtt ttaatttaat tatatcagaa gctaatagcg attttcactt gtccacaaaa
     9481 cttctaaaac atccaattcc ctagcagtta gtatagttat gttttttttt tcgttcataa
     9541 tacatcacct ttataatcta tatactttat taaattatag tattatataa ttagaatgtc
     9601 aacatttgat atatttagtt tccgtgtatt agtgattgta ccgaatcagc ttatgcgtct
     9661 caagtccaga ccgtgcattg tatatgtatt tgtgagcaat cttcttgtcc cagccgttgc
     9721 agccgtaggg agccttgtcg gctgcagcgt tctttcacaa aatccctgca agtcaagttg
     9781 caggttagga aaaaagcaca tttgactccc tatatcataa cctaagatgt gtaaaatttg
     9841 ttttttaatt ttaaaaacaa taatattata aataatataa ttgacaaaat acaatacaag
     9901 caatataatg acattacaga gcaattgtaa agtaattata ttgcttgtac acttgcttta
     9961 tattaaacaa aggatataga gagtagtggg gggaaaatga atggaagaaa gttatttaaa
    10021 gttacaaaaa tatttagaag aattaattcc ttctaaatat tatgagcgat taggagctgt
    10081 ttttagaaca aaaagaaaca tgtacgtata tgatacgggt actggaaagg ttttttcttg
    10141 caatgaaatt gaatatagaa tatttgagag tatatttaat aattttgatt taatgaaaga
    10201 aaaattaaaa aattatcaag aagaagatat aattcatgcg attgatagta tcatagaggt
    10261 aattaaaact gagaatattc tacaagcgac agattataaa gaatttgcaa gagaaacaga
    10321 tcaggagctt aatgcagttc tcaattattc tttacagagt ttgatattag aagtgacaca
    10381 aaagtgcaac tttagatgta aatattgcat ttaccatgat tataactctc tttatagaga
    10441 ctatactgca aaagatatgt cttgggagac tgcaaaaaaa acaattgatt atgttaaggc
    10501 acattgtggt gaaaaagact tatcaattgc attttatggt ggagagcctc taataaatta
    10561 tgatttaata catgatgtta taggatattg taaacagatt atgtctgata aaagtttgat
    10621 tttctcattt actacaaatt tatcgcttat ggataagaat aaagctgcat tttttgccaa
    10681 agaaggctgt tacattatgt gcagcataga tggtccttca ataatacatg atgcatatag
    10741 ggtagatgcg gaaggaaatg gaacatttga attagttatg caaggactaa aaaatttaat
    10801 agaagcgtat ggtaatgatg ccgaggaaaa aattagtttt aatgttgtaa tatgtccacc
    10861 ttatattaaa gataagtttg atgcaataaa agattttttt tctcaaatag aatggttgcc
    10921 tccaaagtta acgataaaat attcttatgt tgaaagtggc agtttaagag aagaagatat
    10981 agattataca tatttctcaa aagatgaaag aaaaaatcag gtatcagaga ttgctccagt
    11041 agctgaatgg acaatgaata agctcataga taaatcagat actgattatc ttccatatag
    11101 ttttgcaaga gatgctttgg ttagggtaca taaaagattt ttgtcagata ggccatatga
    11161 gaaaatgaaa cgtaatggat gctgtattcc aggtggcaga aggatatatg ttgatgtgga
    11221 tggaaatatt gcattgtgcg agagggttgg caaatgtcca ccaattggga acattgatac
    11281 tggtatagat atcaataaaa taaaaaaata ttatttggaa gattatgaga aaaaatcatt
    11341 agataaatgt aaaaactgtt gggcagttaa tttatgcaat atatgttatg ctgcatgtta
    11401 tcgtgaagat ggaattgata tttctagtaa aaatgaatta tgttatatac aacgaaagca
    11461 aataaaaggt gagttgattt tgtattatga agtcatggaa gaagcaccag atgttttggc
    11521 taattttgaa gaaatagaag ttttttaaag gttataatta ttataataat ttaacataaa
    11581 aaaattaaag gaggaattga gcatgaaatt agtaaatcca ttgggcaggg aaattgaaaa
    11641 gttgaatagt caggctgact atgtgagccc tctttccgga tgtgtttgct cagggccaac
    11701 agggacagca gtaagccata acaagggacc aggttggtgc gtcggatatt gtggtggtga
    11761 atcttcagaa acgagaaatg ccaacgcaga actagcaaga tatgcataaa taagataaag
    11821 ggaatgctat taaaggaacc ataatagtat tccctttttt caaggagaag atatggaaat
    11881 gaaaggcagg ataagtccgt ctgaatatat aaagacaata attaaggttc tagaattatt
    11941 atttagaagt tcaaagttgt atacatcttt aattctaata gtaaatattt ttataggaat
    12001 cattgtccca atcaacgtta tcatatggaa aaattttatt aattcagcag tggctggtat
    12061 ttcagataga agctggcaga ctgctatatt ttggatttcc atatattctt taatttatat
    12121 tcttgataat atattgagta aaataaatga gtttatagaa aatattttag cttctaaagt
    12181 taatatattt acaacaaaat taatactaga tagattagta gatatcccaa tggagttttt
    12241 ttgataattc ggaaaattat gataaaattc aaaaaaataa atacagaatc taacagtaga
    12301 tcaatgagta ttttaaggac gttggtaaat ttaattaaaa gtttcaatac tatgattgga
    12361 acgattataa tcttattaca gtttagtcca ttactaatta taatttgttt tattacatgt
    12421 gtaccaacat taattattag tatgaaaatg gcttataagc agtttaatat atataacaat
    12481 agatttgaaa atttacgata tatatcatat ttaaaaaaaa aaatatgatg accatgtatg
    12541 aaaatattaa agaaatgaaa gtcaacaatt ctatcccttt tttttttttc taagcatata
    12601 gataagcaat ataatgaatt tatgaaagaa gatatgaaga ttcgtggaaa atatttagta
    12661 agaatatctg gaatgaatac tatggaacag gcactcattt tattaattcg tatttatatt
    12721 actacaagag ttataaaaaa aaaaaacaaa caattggtgc attgtccctt tatataagtt
    12781 ctatagataa cttcagaaat tctgttgtta ttatacttaa tacgattgtt tcaatatttg
    12841 aagatgggct ttatattaat aatttatttg aattttttag aaatgactaa gaaaaaaaaa
    12901 aaataacgaa ggattattat ttgatgccga atttaagaaa attgaattca aacatgtttg
    12961 gttcaaatac cctaatacaa ataattatat tttaagagat ataaattttg tgatagatgc
    13021 aaaaaaaaag ttattctata gttggattaa atggatctgg gaaaacaaca ttaattaagt
    13081 taatgctaaa cttatatgaa ccagataagg gagaagtact gatagatggt gtcaatatta
    13141 gagaatttaa taaaaaggag tacgttaaaa atataggcgt ggtttttcag gattttataa
    13201 aatatcccct aacagttagt gaaaatatag gaataggtga tcctgaaaat attgataatt
    13261 tcaaccaagt tgagactgcc gcagtattat ctggagccaa tgagtttatt agaaacttac
    13321 cagataagta cgaaactaaa ctattaagag agtggagcgg aggtatacaa ttatcattag
    13381 ggcaatggca aaaactagct ataagtcgag cttttatgaa aaagtatcca ataataatat
    13441 tagatgagcc aaccgcatca ttagatgcaa ttgctgaatt tgaactatat aagaaattca
    13501 aacaaatggt ttcaggaaaa acttgtatat tgatagcaca taggttttcc acaataaagt
    13561 tagcagatac aattttagtg ttaaaagatg gggaaattgt tgagactggg agccatgagg
    13621 aattaattaa gaaacaaggg gattatgctg aattatatga tttacaggca caaacgtaca
    13681 aggaataggg gatgtggaat ggatacttat ctatgcatta ataataaacg tattccatgc
    13741 tatttaaata aagtggattt taatactgat atattagctt gtgcactggt ggtaaaaagt
    13801 ggttctttac aggacgagat tccgggtaca gcacatattt tggaacatgt aatgatagaa
    13861 aatcaagtaa ttaagaattg ggattgggat acgattgata gaagagcaca tactgatttt
    13921 tatgaaacta catactattt taaaacaaat aaaaacatat ttaatatagg gttagaattt
    13981 attgaaagta ttgttgatgg attatggctc aatgaagaga attttgaatt agttaaaaaa
    14041 gaatattgta gatgagtata attctcttta aaaaaaagat gaatttttaa ttttgaatgc
    14101 cctattaaag aattcagctt ttgagaatca tattccgata ggaacattag aaacgattga
    14161 aaaaagttac atttaaagat attaaatctt attatgaaaa aaaaattatc tgtcagataa
    14221 tatttttatt gtcattagtg gatatgtaag cttatgcgaa ctaaaaaaaa aacagtatat
    14281 aaagatatta attttatcga agaagaatta aacataaaaa aaaaatagca gaagagtatc
    14341 ccaggttagt atttcaaaat gatatatata atgtattacc taataatgat aattatattt
    14401 taatgttttt taacattaat aaaaccaaaa tccgatattc aaaaaaaata taaaccaaat
    14461 aacagaagag gcactattaa ttgaatgctt acaagctatt ttgaatgaat atacaaaaga
    14521 gtttacaaaa tgtgttaaat gtaatttggt tcaagtttcg ttcggttatt acttaataaa
    14581 agtagtaata ataaaagaag atagtgttaa ttttgcgaca gaatcaatta ttaagaaaat
    14641 actaagttta aatgtaaata tgtattttca aactataaca gaaattattg agaatgtaca
    14701 tatagagcag aaaataggaa ctaatttggg tattatactg gaagaacaaa ttaattcttt
    14761 tttctttatt gtgagaaata tgatgacaaa gatgagtcca attctatttt ctgtgctgaa
    14821 agaataataa ataaattaga tgaaatattg cattcaaata aataccgagt tattatataa
    14881 atattattga attaaattat aatttaatct aatgtgatta acagatagat ttgagcatat
    14941 agtaggacat gtggggattt tagggcagca caaggagatg aaatagttat gtttaaaatt
    15001 ttggtgattg aagatgataa agacatatct gaattattaa aattttttct tgaagataat
    15061 ggatattcag taaggatagc tgataatggc atagagggaa tagaaatata tcgtcatgaa
    15121 agtattgact taatactttt agacatttta ttgccaaaag tcgatggata tatggtatgc
    15181 aaaacaatta gaaaagaatc tgatatacct gttattatga ttacagcact tacaagtgag
    15241 gacgaacaga taagaggtta tgatcttcag gtagatgatt atgttactaa acccttttct
    15301 atgccggttc tattaaagaa agtcgctgct gtactacgaa gaataaatgg agatcaagaa
    15361 aaaaatatat tattttataa agatttagtt ttagatacag ataattaccg tgtatcaatt
    15421 aaagagagga caattgatct tacgaaaaaa gaatttgaaa tattaagaga gttattaatg
    15481 aaccagaata aaattttaac aagagaactt ctcttaggaa gggtctggaa atatgaatac
    15541 ttcggaaatg atagaattgt agataatcat ataaaaaata tacgaaaaaa attaggagta
    15601 gattatattg aaacaattaa gggagtcggc tatagaattg ataaggttaa ttagaagcaa
    15661 attattaatc aaagtatttt tattaacgct tattgtattg tggggactaa ctggccttac
    15721 atatactttt atactgatcg ttactcccag attatatcaa acagaattgc agagaaattt
    15781 agatacagca atagaacgta ccataaagga acttagtagc gtgaatttaa aaagagggaa
    15841 agaaataatt aaagatttat caaatagtta taatattgca attatgctct ttgattcaaa
    15901 tggaaaacaa attgattacg gagaagatat tttatttgtt gcagatggta acacagcttc
    15961 tgttctagag agaaagagta ttacacaaac atatgaggta aactttaatg atatacaaga
    16021 aatatatact atgacagtat tgggaaaaaa gtgaagaaat aaataggttt aacttattat
    16081 taaaaaagaa gtttattatg gatttgtatt gttatacttt gcatatctat tataatttct
    16141 tttttttata caaaatatat tacaatgcct ataaaaaaca tatcgtcata ttccaggaaa
    16201 ctggcagaat taaattttac ttctcattat tttaataatc ggattgatga aattggaaat
    16261 ttagcagaaa acttaaatga actatcagag catctaaata atgcattaga tgagttgaga
    16321 accgctaatg atagtttaaa gaaagaaata gaatatgaaa aaaaagtcga gcaacaacaa
    16381 atgacattat tttcggcctt atctcatgaa ttaaaaacac caattactat tttaaaggga
    16441 caaactcaag gaatgttgta taatgttgga ggatataaag atagagacaa atatttgaag
    16501 cgctcctttg aagttatctg tatgatggag cagctcgtaa aagaaatttt aattgcatct
    16561 catattcaat cctcaatgta taaaataaaa acagaaaata ttaatttatc agaggaatta
    16621 tatgacatca ttaaggaata tgatgaaatg attcttctga aaaaaaaagt aaatattcaa
    16681 attaagttaa tggattttag tattattttc gcagatagaa atttaataaa aaaaaagtat
    16741 ttagtaatct gattagtaat gcaattcatt attctccaaa aggggaaagt attagtattt
    16801 ctactaaaat cattggtgat aatcccatta tatgcataaa aaatacaggt acacatatag
    16861 aggaaaacga aaagacttct ctattccaac catttacacg gggtgaaaaa tcaagaaata
    16921 gaaataccgg tggtagtgga atgggtctat atattgctaa attaattata gaattgcatc
    16981 atttttcaat agcgatgaaa aatgaacaag atggtgtatg tgttgagata actttaaata
    17041 aacaaagtgt gaaatagaaa tagcgtaaag aatttcaggg attcaatcgt tcatgattga
    17101 atcccgcttt ttaatatcag aaatacactc attgccatac gttaattttg ccggcatctc
    17161 ttctttaaaa atctcctact aatatcccaa cagattttgc aataaataaa atacaaaaaa
    17221 acatataaaa gacatataaa aagcacgatg attatatata caaatggtaa gatggttaaa
    17281 aagttattgt aaaggagcgt aaaaaatgaa agtatctaaa aacatgctat taataatgac
    17341 atttgcagta ttaactttag gaggttgtag tcaaaaagaa gatacaaata cacccccaaa
    17401 tagtataagt gaggataatc aaatcaaaac agaaaaaatt aatgagacag aaaacatacc
    17461 tagtttagat gaggcagtta atagtgggat agttactgag ttatcagacc tgagatttga
    17521 aattttacct atgacagttg atgaggatga attagatatg cctgttggcg aagaagcgca
    17581 aagtggagtt aaaaaaataa acgtaaatta ttcttcggaa gtcaaggtaa agataattga
    17641 atatgatact gcgacaaata aaaacaatta tctagatagt gatattaatg atataaaaaa
    17701 agatagtgtt gtctacatat atggtgaata tgttaacgaa actgaaatta aagcggatca
    17761 aattataata tttagagtta aaaaaaaaat aatattgagt aattaaagga aggaagaaaa
    17821 atataatgtg tcttttttgc taatagggca attaaatata tttggagaaa aaaaaaggca
    17881 agtcatttat tttattgttt attttcatta taattaattg catgaacatt agtatgcttt
    17941 ctatattgcg tgttacaaag gaagcagaat tagaaatcaa aaagaataca caggcaaaaa
    18001 taacattaga agtaaaagaa aatgataatc ttattacaaa aacggagtta gaaaaaatat
    18061 tggccgtagg aaatattata gatgtaaata gagtttgcaa agattatgcc ataccgcata
    18121 attttaaaaa ctataaaggt aaaatagaag atgatatcag agacaatatg gtcactttat
    18181 atggctatga tgatttgtca caagacagta gattctctga acttgaaatg aagataacat
    18241 cgggagaaac ggtaaagcct atgagtcagg attcggttgt aattaatcat aatctggcag
    18301 agctaaattc tttacaaata ggggatataa ttgagttttc aaaaaatgac agaactatat
    18361 ctggaaaaat ttgcggtatc tataaatcta gtattgaaga taaacagaga gaaaatataa
    18421 cctctttttt cagaattgaa aatatggttt ttttgagtca aacattaatg gagcaattag
    18481 taaatgaagg taattataac aaagtagtac tttatgttca ggatcctgaa aaattggaag
    18541 atacagtgga taaggtgaaa agtttattag gagaaaaaat agaggttagc acaactgaca
    18601 ccatgtatga aaaacttaaa atgaatctag atcaaattga aaagataacg aatgttattt
    18661 tgatattagt tgttattatt tctgtaattg ttatcacatt aatatatggc atttggataa
    18721 gggatagaaa aaaagaaata gcaattttat taagtctggg taaaagtaaa gtatctgtat
    18781 ttttacaaat atgcttggag tcgtttatgt tgtttgggtg ttcagtaata ttggctgtat
    18841 tagtagggaa tattattaca acttggatag aaagagcgtt gttaacttgg caggattcaa
    18901 gaataggttt aaatataaat ctaaacgtat acgatattgt aaaagttatt gccataggta
    18961 gtttagtatt gattatttca attagcctat ctttggttag aataatcatg gcaaagccta
    19021 gagaggtttt ggcagaaatg gagggataag atgaatgtag taaaacgtgg gctatattca
    19081 gttttacgaa aaaaagtcaa aagtatttta ttattcataa tagtattaag tataagttgt
    19141 tttattatgg cggctatggc tagcaaaaat gcacaagtta ctacacagga caaatcaaga
    19201 gctgtagtgg gtttaagttt aagacttgag ttaaatgaga atgatcgaag agaaagacta
    19261 ttagagatac cagtagaaaa gttgccaaat ggtgctacga tctcaagatc tcccaataat
    19321 gaatttgagt ccgtattaat ggacgacatt ctaaaaattt ctaaagttga aggagtcaaa
    19381 tcttataata taattacagg tgtttttgca gcaaatccag taaattttaa acggatagag
    19441 gatccagata gggatcagta taatgacgag ggtggagtaa acctacatgg aaacctggat
    19501 atggctcaag acataaatat attaaatgga aatattaaat taatagaagg aagatggggg
    19561 acagaagcag atcataatgt ttgtgttgtt tctaaagaaa tagctgaaaa aaataaaatt
    19621 aaaataggag acttgctaga atttaataat tatcgtgaca aggaaggttc aacaatttat
    19681 aaagcagaat taattggtat atatagtacc gcgaaagaaa tcacaccatt gatgcgaggg
    19741 gatacttatc gtacagagaa tgctgtgttt actgatttga gatttcctga aaaaccaata
    19801 ggagcagaag gagatccgtt atatcaatat gctatattta accttgatgg taataaagac
    19861 tacgatacga taaaagaaaa tgtaaaaaaa gcggatgtga attggaaaag atatgattta
    19921 attgataata gtggaaaaag tgaagtactg gcagataatc ttggacagct ggggaaaatc
    19981 agtaatgtta tgtttgctat atgtataatc tctgggtttt tgattctatt tctgaatttt
    20041 atcttctgga taagactaag aaaagttgag attggtattc taatggcgtt aggtaaatct
    20101 aaattagaga ttttagcaca actgataata gaagccagct ttattacact attttcattg
    20161 ttaacatcac tttttatatc accaagtata tcgcagaaat tgacaactta tatagttgcg
    20221 gaacaagaag aacaacagaa taaaatcgac gggataaata aggcgcaaac tgcgggcctg
    20281 gaatacgatt tcagatgaga aggtcgtagg aactactgca aatatcactt ataaaattat
    20341 tataaatgtt agtttactgg ttattattat ggttattgga gcagtatctt tggcaagtgt
    20401 ttctattatg aaaaaaaagc ctaaagagat actaagtgaa atataaatag gagagtgttg
    20461 tatgatattg gagttgaaaa atgtagatta ctattataag gctaataaaa gtaaaaagat
    20521 attatctgat ataaatattg gatttgagga aggtaaaatg tatgcggtat taggcccaag
    20581 tggttcgggt aaaacaactt ttttatcttt attggctgga ttggatattc ctgtaaaggg
    20641 agaaatactt tatgatggtg agaatatttt aaagaatgga ttgaattttc atagaaaaaa
    20701 taacgtttca ttggtatttc aaaattataa tctgatagat tatttaacac caaaagaaaa
    20761 tgttaggcta ggtggagatg gagaaccgga aaaattatta tctgaagtgg gaataactaa
    20821 agaagagggg aaaagaaatg ttttgcagtt gtcaggcggt caacagcaaa gggttgcaat
    20881 tgccagagct cttgccagta attccaaagt attgttggca gatgagccga ctggtaattt
    20941 ggatgagcag acagcatatg aaattgtgac attgttaaag aaaagtgcac acatgatagg
    21001 aaaatgcgtg atagttgtta cacatagtaa agaactagca aaacaagcgg atgaagtaat
    21061 aaagataaag aatggaaaca tagaattggt gaattatgaa gaagattaat ggaaaaaatg
    21121 caatcccact tttaatggat acgtacatag ctttattcta aagggtgtat ggttcatttt
    21181 ggcatatgta ataaagcctg taattcatag gagtaattat aagcagcgtg ttttagaaaa
    21241 ggcctaagcg gttgactaaa acattctgct ttttgtttct cttttatctg gggtgtgtat
    21301 tggatttcta ctggaaaaaa cttttactta attttcgaaa gcatataatt atgatgtaga
    21361 aatggcgtgg gttatcgtat ataatgagaa agatattata actagtacct aataaacaca
    21421 cctggggtat gaccaagagg agctaatgtg aaaaagcata tactactact cagcaatctc
    21481 attatcatca tttccattat aattggattt atcggtatcg tgtatcgaga taccaccgcg
    21541 taccagga
//
