LOCUS       NZ_CP070896            21670 bp    DNA     circular CON 17-JUN-2024
DEFINITION  Lacrimispora xylanisolvens strain ASCUSBR21 chromosome, complete
            genome.
ACCESSION   NZ_CP070896
VERSION     NZ_CP070896.1
KEYWORDS    RefSeq.
SOURCE      Lacrimispora xylanisolvens
  ORGANISM  Lacrimispora xylanisolvens
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Lacrimispora.
REFERENCE   1  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Hungatella xylanolytica ASCUSBR21
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) R&D, Ascus Biosciences, 6450 Lusk Blvd E209,
            San Diego, CA 92121, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-MAY-2019
            Assembly Method                   :: Canu v. 2.1.1
            Assembly Name :: Hungatella xylanolytica ASCUSBR21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017084465.1-RS_2024_06_17
            Annotation Date                   :: 06/17/2024 10:45:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,443
            CDSs (total)                      :: 6,353
            Genes (coding)                    :: 5,667
            CDSs (with protein)               :: 5,667
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 686
            CDSs (without protein)            :: 686
            Pseudo Genes (ambiguous residues) :: 0 of 686
            Pseudo Genes (frameshifted)       :: 599 of 686
            Pseudo Genes (incomplete)         :: 95 of 686
            Pseudo Genes (internal stop)      :: 24 of 686
            Pseudo Genes (multiple problems)  :: 30 of 686
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:11:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 2048109
            Orig. end                         :: 2069779
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070896.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..21670
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="ranthipeptide"
                     /region_number="6"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     cand_cluster    1..21670
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..21670
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:11670](-)"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..11670)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     misc_feature    699..708
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     misc_feature    1165..1180
                     /note="TFBS match to ColR, Phenol-responsive regulator,
                     confidence: medium, score: 24.29"
                     /tool="antismash"
     gene            1336..1866
                     /gene="raiA"
                     /locus_tag="JWH23_RS11390"
     CDS             1336..1866
                     /GO_component="GO:0005840 - ribosome [Evidence IEA]"
                     /GO_component="GO:0022626 - cytosolic ribosome [Evidence
                     IEA]"
                     /GO_function="GO:0045182 - translation regulator activity
                     [Evidence IEA]"
                     /GO_process="GO:0009386 - translational attenuation
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="raiA"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005362075.1"
                     /locus_tag="JWH23_RS11390"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ribosome-associated translation inhibitor RaiA"
                     /protein_id="WP_277409159.1"
                     /transl_table=11
                     /translation="MRFTITGRNIEVTAGLREAVEDKLGKLDRFFAPATEATVRLSVQK
                     DIQKIEVTIPVKGHIIRAEESSNDMYVSIDLVEEILERQLKKYKNKLIDKKLNAPSFST
                     AFLEYESAVDDDVEIVKTKKFAVKPMDPEEACVQMELLGHSFYVFLNGDTDEVNVVYKR
                     KGGTYGLIEPELL"
     gene            complement(1935..3626)
                     /locus_tag="JWH23_RS11395"
     CDS             complement(1935..3626)
                     /GO_function="GO:0004553 - hydrolase activity, hydrolyzing
                     O-glycosyl compounds [Evidence IEA]"
                     /GO_process="GO:0005975 - carbohydrate metabolic process
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012551.4"
                     /locus_tag="JWH23_RS11395"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="endo-1,4-beta-xylanase"
                     /protein_id="WP_277409160.1"
                     /transl_table=11
                     /translation="MKRLLGKTGAICISILVCLNMTMGMSLADEQATKDQEKKEVHIEN
                     LTPLKDIYKGKFLIGNIYNSFNLTGADRDMVLHHFNVVTPENMMKPDAMQKQKGVFTFE
                     SADAMTGFCQENGLKTVGHTLAWHGQTPDWMNAACGREEAIGRLRDHISNVAGHYSGKL
                     LSWDVVNEAIQDGARLPADGNWKSCLRDTPWLRNIGNDYIELAFQFAHEADPNAKLYYN
                     DYNLNDNNKAEIAAAMFTDLKKKGVPIDGIGMQGHYSTTLPVATVEHSLELFKKTGAEI
                     SITELDVGVSQAQASGLTKEEEIAQGQTYAQLFKLYNQYSDVIERVTFWGYADTRSWRS
                     SNFPCLFDGNYKAKEAYYAVADPDGYLKKHPLKEIPEPNTLNAVKGTPVIDGTVDEIWN
                     QAKEEPVRVMTMAWQGATGTVKTLWDEKNIYVLVRVKDKTLNTDNKNAYEQDSVELFLD
                     ENNDKSYYYQEDDGQFRVSCKNMVTFGSNGKREGFQSSVKVTEEGYLVEARIPLTTTAE
                     KGKVMGFDVQINDSNERGERISVAKFNDDSDNSWQSTARWGNLLLK"
     misc_feature    complement(3716..3725)
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(3821..4746)
                     /gene="trxB"
                     /locus_tag="JWH23_RS11400"
                     /pseudo=""
     CDS             complement(3821..4746)
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0004791 - thioredoxin-disulfide reductase
                     (NADPH) activity [Evidence IEA]"
                     /GO_process="GO:0019430 - removal of superoxide radicals
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="trxB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015553807.1"
                     /locus_tag="JWH23_RS11400"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="thioredoxin-disulfide reductase"
                     /pseudo=""
                     /sec_met_domain="Pyr_redox_2 (E-value: 1.5e-22, bitscore:
                     78.8, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNEIYDVVIIGSGPAGLTAAVYGKRAELKMVVIEKEVASGGQILN
                     TYEVDNYPGLPGINGFDLGMKFRDHAEKLGADFVTDEVLRIEAADGEFTVVGQEKSYVT
                     KSVIIATGALYRKLSVVGEKELTGMGVSYCATCDGAFFRNKVAAVVGGGDVAIEDAIFL
                     SRMCKKRCT"
     misc_feature    complement(4787..4800)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 22.68"
                     /tool="antismash"
     gene            4896..5627
                     /locus_tag="JWH23_RS11405"
     CDS             4896..5627
                     /NRPS_PKS="Domain: PKS_KR (4-170). E-value: 4.9e-13. Score:
                     41.3. Matches aSDomain:
                     nrpspksdomains_JWH23_RS11405_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002587455.1"
                     /locus_tag="JWH23_RS11405"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="SDR family oxidoreductase"
                     /protein_id="WP_104434518.1"
                     /sec_met_domain="adh_short (E-value: 3.6e-38, bitscore:
                     129.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 6.7e-06,
                     bitscore: 24.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRKTVLVTGASRGIGKAIAVKFAKKGYNVVINCLHNEDRLLQTR
                     KELESYQISCLSYMGDMGDMNQCQELFQMIKKQFGSLDVLVNNAGISYIGLLQDMTTEA
                     WDRIIRTNLTSAFHCSKLAIPGMLERKQGKIINISSIWGVSGASCEVAYSATKGGINAF
                     TKALAKELAPSNIQVNAVACGAIDTEMNQFLSEDELIALIDEIPAGRLGKAEEVADLVY
                     HLGYKNSYLTGQIIGLDGGFI"
     CDS_motif       4908..4976
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_JWH23_RS11405_0001"
                     /evalue="5.40E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="JWH23_RS11405"
                     /protein_end="27"
                     /protein_start="4"
                     /score="12.6"
                     /tool="antismash"
                     /translation="TVLVTGASRGIGKAIAVKFAKKG"
     aSDomain        4908..5405
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_JWH23_RS11405_PKS_KR.1"
                     /evalue="4.90E-13"
                     /label="JWH23_RS11405_PKS_KR.1"
                     /locus_tag="JWH23_RS11405"
                     /protein_end="170"
                     /protein_start="4"
                     /score="41.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TVLVTGASRGIGKAIAVKFAKKGYNVVINCLHNEDRLLQTRKELE
                     SYQISCLSYMGDMGDMNQCQELFQMIKKQFGSLDVLVNNAGISYIGLLQDMTTEAWDRI
                     IRTNLTSAFHCSKLAIPGMLERKQGKIINISSIWGVSGASCEVAYSATKGGINAFTKAL
                     AKE"
     gene            complement(5586..6056)
                     /locus_tag="JWH23_RS11410"
     CDS             complement(5586..6056)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006774435.1"
                     /locus_tag="JWH23_RS11410"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MarR family transcriptional regulator"
                     /protein_id="WP_277409161.1"
                     /transl_table=11
                     /translation="MRQEEECCLACFVKIDKVYQKLCSQSVSEYGFTPNEIVVMMFLAN
                     SEGLKSASEIAQYRNISKGLIARSVDSLSEKGYLTADRDKNDRRLVRLQLTEKSEEVVE
                     RIRRCRKEFVEELHREIPEEDLKILHRTASIMNQNVESFLNKPSVKTDDLSR"
     misc_feature    complement(6250..6261)
                     /note="TFBS match to CcpA, Catabolite control protein A,
                     confidence: medium, score: 18.05"
                     /tool="antismash"
     gene            complement(6276..6549)
                     /gene="yajC"
                     /locus_tag="JWH23_RS11415"
                     /pseudo=""
     CDS             complement(6276..6549)
                     /GO_component="GO:0005886 - plasma membrane [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0009306 - protein secretion [Evidence IEA]"
                     /codon_start=1
                     /gene="yajC"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006778824.1"
                     /locus_tag="JWH23_RS11415"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="preprotein translocase subunit YajC"
                     /pseudo=""
                     /transl_table=11
                     /translation="MSMVGWGLYIAVIFGFMYFIAIRPQKKEKKRQQEMFASIAVGDSI
                     LTSSGFYGVIIDMTDDTVIVEFGNNKKLQNSYAEVTNCTG"
     gene            complement(6628..7770)
                     /gene="tgt"
                     /locus_tag="JWH23_RS11420"
     CDS             complement(6628..7770)
                     /EC_number="2.4.2.29"
                     /GO_component="GO:0005737 - cytoplasm [Evidence IEA]"
                     /GO_function="GO:0008479 - tRNA-guanosine(34) queuine
                     transglycosylase activity [Evidence IEA]"
                     /GO_process="GO:0006400 - tRNA modification [Evidence IEA]"
                     /codon_start=1
                     /gene="tgt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) bTGT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009004146.1"
                     /locus_tag="JWH23_RS11420"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="tRNA guanosine(34) transglycosylase Tgt"
                     /protein_id="WP_277409162.1"
                     /sec_met_domain="bTGT (E-value: 9.2e-155, bitscore: 513.6,
                     seeds: 1816, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNYKIIAKDGRAKRAEVTTVHGTIQTPVFMNVGTVAAIKGAVSTD
                     DLREIKTQVELSNTYHLHVRTGDRLIKEFGGLHQFMNWDRPILTDSGGFQVFSLTGLRK
                     IKEEGVYFQSHIDGHKIFMGPEESMQIQSNLASTIAMAFDECPPHPATREYMQNSVDRT
                     TRWLERCRKEMARLNELPDTINKDQLLFGINQGGTFEDIRIAHAKTISAMDLDGYALGG
                     LAVGESHSEMYRILDETVPYLPENKPTYLMGVGTPANILEAVDRGVDFFDCVYPSRNGR
                     HGHVYTNHGKLNLFNSKFELDHKPIEEGCQCPTCRSYSRAYIRHLLKAKEMLGMRLCVL
                     HNLYFYNTMMEEIREAIENHRYGEYKERKLAGMMAGDSQA"
     gene            complement(7787..9938)
                     /gene="secD"
                     /locus_tag="JWH23_RS11425"
                     /pseudo=""
     CDS             complement(7787..9938)
                     /GO_component="GO:0031522 - cell envelope Sec protein
                     transport complex [Evidence IEA]"
                     /GO_function="GO:0015450 - protein-transporting ATPase
                     activity [Evidence IEA]"
                     /GO_process="GO:0006886 - intracellular protein transport
                     [Evidence IEA]"
                     /GO_process="GO:0043952 - protein transport by the Sec
                     complex [Evidence IEA]"
                     /codon_start=1
                     /gene="secD"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_015553083.1"
                     /locus_tag="JWH23_RS11425"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="protein translocase subunit SecD"
                     /pseudo=""
                     /transl_table=11
                     /translation="MKSNKGKGLLGLIIALVMVGLFGYFGYTTMGDIKLGLDLAGGVSI
                     TYQAKEEKPSEEDMKDTIYKLQQRVQNYSTEAEVYQEGDNRINVDIPGVSDANAILEEL
                     GKPGSLTFTDEAGKVILNGNQVSTAKPVITENNGIKQYMVDLTFTDDGKRYLVM"
     gene            complement(10001..11395)
                     /gene="scfB"
                     /locus_tag="JWH23_RS11430"
     CDS             complement(10001..11395)
                     /GO_function="GO:0051539 - 4 iron, 4 sulfur cluster binding
                     [Evidence IEA]"
                     /GO_function="GO:1904047 - S-adenosyl-L-methionine binding
                     [Evidence IEA]"
                     /GO_process="GO:0031179 - peptide modification [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="scfB"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PTHR43273"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002601552.1"
                     /locus_tag="JWH23_RS11430"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="thioether cross-link-forming SCIFF peptide
                     maturase"
                     /protein_id="WP_277409163.1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 8.9e-25,
                     bitscore: 85.4, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PTHR43273 (E-value: 1.7e-77, bitscore:
                     259.5, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 1.5e-14, bitscore: 53.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.5e-12, bitscore: 46.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1e-17, bitscore: 62.8,
                     seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIHQYINNGFHIIMDVNSGSVHSVDPVMYDAVKIAAPLVPDMEKA
                     AALPKEAKEKVLLELLSTYDEAEVREALEEIQFLIDEGELFTKDIYHDYVVDFKKRKTV
                     VKALCLHIAHDCNLACKYCFAEEGEYHGRRALMSFEVGKKALDFLIANSGNRKNLEVDF
                     FGGEPLMNWEVVKQLVEYGRSKEKEYNKNFRFTMTTNGVLLNDEIMEYCNREMSNVVLS
                     LDGRKEVNDQMRPFRNGKGSYELIVPKFQKFAKLRGEKDYYIRGTFTRNNMDFSKDVLE
                     FADLGFESMSIEPVVAQDEEDYSIRQEDIPAILEEYDKLAVEYIKRQKEGKGFNFFHFN
                     IDLTQGPCVAKRLSGCGSGTEYLAVTPWGDFYPCHQFVGEEEFLLGNVDTGVTNTQIRD
                     EFKLCNVYAKDKCRDCFARFYCSGGCAANSYNFHGSITDAYDTGCEMQKKRIECAIMIK
                     AALAGE"
     aSDomain        complement(11063..11395)
                     /aSDomain="Ranthipeptide_rSAM_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing rSAM protein in a
                     ranthipeptide/SCIFF cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JWH23_RS11430_Ranthipeptide_rSAM_RRE.
                     1"
                     /evalue="3.90E-27"
                     /identifier="RREFam024.1"
                     /label="JWH23_RS11430"
                     /locus_tag="JWH23_RS11430"
                     /protein_end="111"
                     /protein_start="0"
                     /score="85.4"
                     /tool="antismash"
                     /translation="MIHQYINNGFHIIMDVNSGSVHSVDPVMYDAVKIAAPLVPDMEKA
                     AALPKEAKEKVLLELLSTYDEAEVREALEEIQFLIDEGELFTKDIYHDYVVDFKKRKTV
                     VKALCLH"
     gene            complement(11524..11670)
                     /gene="scfA"
                     /locus_tag="JWH23_RS11435"
     CDS             complement(11524..11670)
                     /codon_start=1
                     /gene="scfA"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR03973"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: SCIFF"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002601553.1"
                     /locus_tag="JWH23_RS11435"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="six-cysteine ranthipeptide SCIFF"
                     /protein_id="WP_097003442.1"
                     /sec_met_domain="TIGR03973 (E-value: 8.7e-25, bitscore:
                     84.9, seeds: 29, tool: rule-based-clusters)"
                     /sec_met_domain="SCIFF (E-value: 3.9e-25, bitscore: 86.0,
                     seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHVKTLSSSTLKESMKKGGCGECQTSCQSACKTSCTVGNQSCEN
                     SNR"
     gene            11854..12213
                     /locus_tag="JWH23_RS11440"
     CDS             11854..12213
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006773659.1"
                     /locus_tag="JWH23_RS11440"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="TIGR04086 family membrane protein"
                     /protein_id="WP_170824178.1"
                     /transl_table=11
                     /translation="MEKSKLQVTLRNLLVTYILTGVLLVILALALYRFRLKEGQIRLGV
                     NAVYVITCLFGGILMGKSIKQRRFFWGLLLGLLYFLVLLAVSFMLNRGINGSMNQILTT
                     MAICAASGTAGGMLS"
     gene            complement(12849..14096)
                     /locus_tag="JWH23_RS11445"
                     /pseudo=""
     CDS             complement(12849..14096)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_008725423.1"
                     /locus_tag="JWH23_RS11445"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="hemolysin family protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MLILLVSLSAFFSSAETALTTVNRIRVRTLAEAGNKNAITLTKIL
                     ENQGKMLSAILVGNNVANLTASSLSTTLVMSIWGNKAISIGTGILTLVILVFWRNLP"
     misc_feature    14140..14149
                     /note="TFBS match to ToxT, Regulator of MSHA biosynthesis,
                     confidence: strong, score: 18.31"
                     /tool="antismash"
     gene            complement(14214..14411)
                     /locus_tag="JWH23_RS31585"
     CDS             complement(14214..14411)
                     /EC_number="3.4.23.36"
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0004190 - aspartic-type endopeptidase
                     activity [Evidence IEA]"
                     /GO_function="GO:0016787 - hydrolase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006508 - proteolysis [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013421.4"
                     /locus_tag="JWH23_RS31585"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="signal peptidase II"
                     /protein_id="WP_349773203.1"
                     /transl_table=11
                     /translation="MAFSIALGGAISNLYDRLVRHYVVDYFSIQYGRLKKVVFNLGDLF
                     IFLGAGLIIIIETIRAFKER"
     gene            complement(14698..16096)
                     /gene="clpX"
                     /locus_tag="JWH23_RS11455"
                     /pseudo=""
     CDS             complement(14698..16096)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0008270 - zinc ion binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0046983 - protein dimerization activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene="clpX"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009002236.1"
                     /locus_tag="JWH23_RS11455"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="ATP-dependent Clp protease ATP-binding subunit
                     ClpX"
                     /pseudo=""
                     /transl_table=11
                     /translation="MEDNKIQNSDIDKEKNEDESEYEKICYVCRRPESKAGSMVSMPGG
                     MNLCHDCMQKAFDSVTQGGLDLSKLPGMPYMNLNLNDLGSLNKDLEIPKKQKIKKRSDK
                     EPKKQLERKDIPAPHTVRQKLDEYIIGQEQAKKAISVAVYNHYKRVYLADTVK"
     misc_feature    complement(16144..16162)
                     /note="TFBS match to LexA_variant_3, Repressor of DNA
                     damage response, confidence: weak, score: 23.65"
                     /tool="antismash"
     misc_feature    16148..16166
                     /note="TFBS match to HgtR, Hydrogen-dependent regulator,
                     confidence: weak, score: 24.62"
                     /tool="antismash"
     gene            complement(16288..17055)
                     /locus_tag="JWH23_RS11460"
     CDS             complement(16288..17055)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012318.4"
                     /locus_tag="JWH23_RS11460"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="trypsin-like peptidase domain-containing protein"
                     /protein_id="WP_277409164.1"
                     /transl_table=11
                     /translation="MQPLKEPTHSDLAVIAVPLKNISSDTLSKIAIASLGKSETLKVGQ
                     GVIAIGNALGYGQSVTVGYISALDRAVQTEDGTNRDLLQTDAAINPGNSGGALLNMQGE
                     VIGINSAKYSSTEVEGMGYAIPISKAQTIIDGLITKKTRTQVADNDQGYLGIQCKNIDS
                     TTSQQLGMPQGVFIYKIVEGGAASQSDLREKDIITKFDGQGIKTYDDLTSMLKYYAGGT
                     KVSLTVQSLENGQYVERNVDITLGKKPADTYQQ"
     gene            complement(17024..17701)
                     /locus_tag="JWH23_RS11465"
     CDS             complement(17024..17701)
                     /EC_number="3.4.21.-"
                     /GO_function="GO:0004252 - serine-type endopeptidase
                     activity [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS11465"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="S1C family serine protease"
                     /protein_id="WP_277409165.1"
                     /transl_table=11
                     /translation="MYDENDNIETGRVNPETNKDEAVTTNFIMRDPEPEKEQSQNTIPH
                     YQEYRYQRTPDQTPYEEEGKKRKKGNFGKKAAAVVGSALVFGIVAGSTIVGINWAAGSY
                     AQNKSVEISRAETLPTTPANNSLPASNTSSISTINDVSSIVDKAMPSVVAITSKVVYES
                     QTWFGPMQQEGEGSGSGIVVGKNDDELLIVTNNHVVQGAKELKVTFIDQTAVDAAIKGT
                     DAQ"
     gene            complement(17875..18162)
                     /locus_tag="JWH23_RS11470"
     CDS             complement(17875..18162)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS11470"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277409166.1"
                     /transl_table=11
                     /translation="MSQVLQKETKPSETTKGTGKPGETKPTTSGTTETTTASAGPGTSE
                     TTKAAFPEETKTTGPGETPTKQQTDTAPTTAATAPGGNTDTVVVPAPPVN"
     gene            complement(18125..18388)
                     /locus_tag="JWH23_RS11475"
     CDS             complement(18125..18388)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS11475"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277409167.1"
                     /transl_table=11
                     /translation="MVKKISAKIAADSGMYKQGTSVDHVPTDKGYDGEDKTKPAVKETK
                     STEAEETSKEENVDATDEFGNPVKTTESSENVTGPTKRNQAF"
     gene            complement(18414..19760)
                     /locus_tag="JWH23_RS11480"
     CDS             complement(18414..19760)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF015755.4"
                     /locus_tag="JWH23_RS11480"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LCP family protein"
                     /protein_id="WP_277409168.1"
                     /transl_table=11
                     /translation="MRNDFDDELNRESTRKERRGSDSKPDSASSSGQPMFKGQSSAGRQ
                     PASAGTTRRQPEDAARPQRTGARQPEENRARTAMEQENRRSRAAKEEGRTPARDQIVIG
                     DGASRQQPRISPQEKAAAASRLAAHTEKKRRIRKFIILAVAEIFTLALIFSYAYVARLM
                     GSIQKPDNFNANQVRNEVMTADQKKHMTGYRTIAVFGVDSRDGNVSKGTNADVIMLCNI
                     NRGTGEIKIVSIFRDTYLNINEGNTYNKINAAYANGGAAQALAAINRNLDLDVTEYVTF
                     NWKSVADGINMLDGVDIDISKAEFRYINSFITETVEKTGVPSVHLKSAGLNHLDGVQAV
                     AYARLRKMDTDFARTERQRLVIQKSFEKAKKADLGLLNRILLMEVDQIGSNLTFSDFTE
                     LLLDIGKYHIGETGGFPYSRGDMTIGKKGDCVIPQTLETNVAQLHKFLF"
     gene            complement(19797..20864)
                     /locus_tag="JWH23_RS11485"
     CDS             complement(19797..20864)
                     /EC_number="2.7.8.31"
                     /GO_function="GO:0016780 - phosphotransferase activity, for
                     other substituted phosphate groups [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Bac_transf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1146: sugar transferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS11485"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="undecaprenyl-phosphate glucose
                     phosphotransferase"
                     /protein_id="WP_349773052.1"
                     /sec_met_domain="Bac_transf (E-value: 3.9e-74, bitscore:
                     246.6, seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVFYFFAANVILETAERNLIRMALHSMRTKGYNQKHILLIGYSRA
                     AEGFIERVRMNPEWGYQIKGILDNKKEWGYEFKGIHVIGKVSDLDEILALNSLDEIAIT
                     LSISEYADLERIVASCEKSGVHTKFIPDYNNMIPTRPYIEDLQGLPVVNIRRVPLTDPV
                     NAMLKRAVDIFGAAFALLVFSPIMLLTAILIKLTAPGPLIYKQERVGLHNRSFHMFKFR
                     SMVVQAPSEEKMKWTTKHDSRVTPVGRFIRKTSIDEMPQFLNVLRGDMSLVGPRPERPL
                     FVEKFKEEIPRYMIKHQVRPGITGWAQVNGLRGDTSITKRIEHDLYYIENWTLGFDIKI
                     LFLTMFKGFINKNAY"
     gene            complement(20878..21216)
                     /locus_tag="JWH23_RS31590"
     CDS             complement(20878..21216)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS31590"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_349773053.1"
                     /transl_table=11
                     /translation="MIKDNQKKFNGFHVVLDGLVIILSYVIAWLLLLLGNWLFSPYKQV
                     LPPQYYFAALLLILPTYLLLYGIFQLYAPKRVQERRYEFTNILKANVLGLLLFTLSLFL
                     VKKKPVFQ"
ORIGIN
        1 gaatatcgca gacttcatag agctttgtgg atttaccgct ctgtccggaa atgataagag
       61 gtgttctggc ctcatcaatt aaaacagagt caacctcatc aatgatacag aaatctaaat
      121 ttcttaaaac catctgttct ttatagatgg ccatgttatc tcttaaataa tcaaatccaa
      181 gctcattgtt ggttacatag gtaatatcgc agttataagc atcacgtctc tcatctgagc
      241 tcatgtcgtt taatacaacg cctactgtca tcccaaggaa ctcatggatt cttcccatcc
      301 actccgcatc acgctttgcc agatagtcgt taacagttac aatctgtaca ccgttgcctg
      361 ccagagcatt caaataagcc ggacatgtgg atacaagagt tttaccttca ccagttctca
      421 tctccgcgat acgaccctgg tgtaatacta caccaccgat taactgcaca cggaaatgtt
      481 ccatattaag aactcgcctt ccggcttctc ttacagttgc gaacgcttca ggcaagatat
      541 catcaagagt ttctcctgct gccagtcttt ccttaaaaaa gcttcgtgtt gttttttaat
      601 tcctcatccg taagtgcaac catggtcggg cgcagagatt ctattttatc cacaatggga
      661 ttaatgattt tcaattctct ttcactatga gttccaaata ttttttgaac caagttcatg
      721 atttattctc ctactctatc tttcaatata caccgtacaa tcctgtatat tgtagcacta
      781 acctgccttt aattcaacga attcataaaa aattaacatt ctggtaataa tctgacctta
      841 tattgccagg tactgccatt ttcttcggca acctccagca aattcaagtt aaaattatgg
      901 ttaacctgac atattgcaca aaaaatttgt tcgattcccg acttttccac attatccaca
      961 ttggattgtg tatttttccc cccattttta tccccacctc taaccctcga atttgcgaaa
     1021 aaaatcagtt atacaccgag ttatccacat tatccacatt tattctccac ataataccag
     1081 cattcccatt acaatgacaa atacgttaat ttttgtatac ttgtcataaa attttctttt
     1141 tcgacgaaaa aatccatttt tcccttgact tttttttaac cttatctata gtttttcaat
     1201 aaattgataa aatataagaa gagtcttttt tacaaaatct tttcttaaat tatcttaata
     1261 ctttacatca ttattgaatt attctaataa atgtgctata ctatacctat ctcaagaaaa
     1321 aggagctgat gacttatgcg ttttacaatt acaggaagaa atattgaggt gacagcaggg
     1381 ttacgggagg cagttgagga caagcttgga aaactggacc gttttttcgc acctgctaca
     1441 gaggcaacag taagactcag cgtgcagaaa gatattcaga aaattgaagt tactattcca
     1501 gtgaaaggac atataattcg agctgaagaa tcaagtaatg atatgtacgt ttccatcgat
     1561 ctggtagaag agatcctgga acgccagttg aaaaaatata aaaacaagtt aatcgacaaa
     1621 aaattaaacg ctccctcctt ttcaacagca tttttggaat atgaaagtgc agtcgatgac
     1681 gatgtggaaa ttgtcaaaac aaagaagttt gctgtaaaac ctatggatcc ggaagaagcc
     1741 tgtgtacaga tggaacttct tggacacagc ttctatgtat tcctcaatgg agataccgat
     1801 gaagtaaatg tggtgtataa aagaaaaggc ggcacatacg gattgattga gccggaatta
     1861 ctatagaaaa ctatttatat ataaaaaatg tcccaggcct gtaaagcctg gggcattttt
     1921 tatatcatgt attactattt taagagaaga tttccccacc gggcggttga ttgccaggaa
     1981 ttatcagaat catcattaaa ttttgctacg ctgattctct ccccccgctc attactgtca
     2041 ttaatctgaa catcaaatcc catcactttc cctttttcag ctgtggtggt caaaggaatc
     2101 cttgcttcta ccagatatcc ctcttccgtc acttttactg atgactggaa cccttctctt
     2161 ttaccattgc ttccaaacgt caccatgttt ttacaggata cacgaaactg tccgtcatct
     2221 tcctgataat agtaggattt gtcattgttt tcatctaaga acagctccac cgaatcctgc
     2281 tcataagcat ttttattatc agtatttaat gttttatctt ttacacggac aagaacataa
     2341 atatttttct catcccaaag tgttttaacg gtaccagttg cgccctgcca tgccattgtc
     2401 ataacgcgga ctggttcttc ctttgcctga ttccaaattt catccactgt tccatcaatt
     2461 actggtgtac cttttactgc gtttaaggtg tttggttctg gaatctcttt aagaggatgc
     2521 ttttttaaat atccatcagg atctgcaaca gcataatacg cttctttggc tttgtaattt
     2581 ccgtcgaata agcaggggaa attggagctt ctccaactcc gcgtatccgc ataaccccaa
     2641 aatgtcactc gttcaataac atccgagtat tgattataaa gtttgaaaag ctgggcatac
     2701 gtctgcccct gagcaatctc ctcttccttt gtaagcccgg atgcctgtgc ctgactgact
     2761 cctacatcaa gttctgtaat tgaaatttct gccccggtct tcttaaacag ttccagggaa
     2821 tgctctacag tggccacagg cagtgtggta ctgtagtgcc cctgcatacc aattccatca
     2881 atgggtacgc cttttttctt taaatcggta aacatggctg ctgctatttc ggccttgttg
     2941 ttatcattta aattataatc gttataatac agttttgcat tgggatctgc ctcatgtgca
     3001 aactgaaatg ccagttctat ataatcgttt ccaatatttc ttagccatgg agtatcccgt
     3061 aagcaggatt tccagtttcc gtctgctgga agtctggctc catcctgaat ggcttcgttt
     3121 accacatccc aggataatag ttttccactg taatgtcctg caacatttga aatgtgatct
     3181 ctcagtctgc caattgcttc ttcccgtccg cacgcggcat tcatccagtc aggagtctga
     3241 ccatgccatg ccagtgtatg ccccactgtc tttaaaccgt tctcctgaca gaatccggtc
     3301 atggcatctg ccgactcgaa agtaaatacg cctttttgct tctgcatggc atctggtttc
     3361 atcatatttt ccggtgtaac cacattgaaa tgatgaagta ccatatctct gtccgctcct
     3421 gtaaggttaa agctgttata aatgtttcca atcaggaatt tccccttata aatatccttt
     3481 aagggagtga ggttttctat gtggacttct ttcttctcct ggtctttcgt agcctgttcg
     3541 tctgccagag acattcccat tgtcatatta agacagacca gaatacttat gcagatcgcc
     3601 ccggttttcc ccagtaatct tttcatctct tattttctcc taataattgt tacaacagtt
     3661 gcgtgttact acaattctat caattaaagt gcatttcaca accggataaa tcatataaaa
     3721 aaacatggtt aattataata aaaaaactac taacttaacg cttaagctag tagttttgat
     3781 tatttattaa atttagaagc ccaacacgcc tgactgtact ttattttcca tatctagtca
     3841 aataacgctc tacacttgta attgcattgg ctccgtctga aacagccgtt gatacctgtc
     3901 ttaactgctt ggtccgaaca tcacctgcag caaaaatacc gggaatattg gtctcacagt
     3961 cctcacctgc cttgatgtaa ccatgatcca tttccacaag gttatcaaag gcttcgctct
     4021 gtggattaat tcccactgca ataaatacac cgtcaacgga aagtttattt gtttcttccg
     4081 ttttggaatt cttaatggta agagactcaa cctggtctcc gccttctatt tcttcgacta
     4141 ctgtatccca gatgatttca acattctcct gattaaataa ctgtgtctgc agtgtctttg
     4201 ctccgcgcag ttcatctctt ctgtgaatta agtacacctt tttttgcaca ttctggaaag
     4261 gaatatggcg tcttcgattg ccacatcgcc tccgcctaca acggcggcta ccttgtttcg
     4321 gaaaaatgct ccgtcacaag ttgcacaata ggaaacaccc attccggtca gttctttctc
     4381 tccaacgacg ctgagttttc tatacagagc tcctgttgcg ataatgactg attttgtcac
     4441 ataggacttt tcctgaccta caacggtaaa ttctccgtct gctgcctcaa tacgaagcac
     4501 ttcgtctgta acaaaatctg ctcccagttt ttctgcatga tcccgaaatt tcatacccag
     4561 gtcaaatccg ttaattccgg gaagccccgg ataattatcg acttcgtagg tattgagaat
     4621 ctggccgcca ctggcgactt ctttttcaat cactaccatc tttagttcag ctctttttcc
     4681 atatactgca gcagtaagac ctgccggacc tgaccctata atcacaacgt cataaatctc
     4741 attcatttta tctacctgct ttctttattt tgtattacag attcttttgt aatcattata
     4801 tctcacccat ctttttgtat gcaatgccct cgttgcattt taaagcagaa tttgttaaaa
     4861 taatagcatc acataacgac agaaagggtg gttttatgtc tagaaaaaca gtacttgtta
     4921 ccggcgcttc ccggggaatc ggaaaggcca ttgctgtcaa atttgcaaaa aaaggataca
     4981 atgtggtcat taactgtctt cataatgaag accgcctttt gcagaccagg aaggaactgg
     5041 agtcctatca gatctcctgt ctttcctata tgggtgatat gggagatatg aatcagtgcc
     5101 aggaactctt ccagatgata aagaaacagt ttgggtctct ggatgtactg gttaataatg
     5161 cagggatctc ctacatcgga ctccttcagg atatgacgac agaagcctgg gaccgaatta
     5221 tacggaccaa tttaacctct gcctttcatt gttccaagct ggcaattccg ggaatgctgg
     5281 aacgcaagca gggcaaaatc ataaacatct cctctatctg gggtgtctcg ggtgcatcct
     5341 gtgaagtagc ctattccgcc accaagggtg ggattaatgc attcaccaaa gctcttgcca
     5401 aagagctggc cccaagtaat atccaggtca atgcagtggc atgcggagcc atcgatacgg
     5461 agatgaatca gtttctaagc gaagatgaat taatcgctct catcgatgag attccagccg
     5521 gaagactggg gaaagcggaa gaggtggcag atcttgtcta tcacctgggt tataaaaact
     5581 cctatctaac gggacagatc atcggtcttg acggagggtt tatttaaaaa gctctccaca
     5641 ttctgattca tgattgacgc ggtgcggtga agaattttaa gatcttcttc ggggatctcc
     5701 ctgtgaagtt cttccacaaa ttccttcctg caccgcctga tccgttccac aacttcctcg
     5761 cttttctccg taagctggag gcgaaccagc cttctgtcat ttttatctct gtctgctgtc
     5821 agataacctt tctcactgag agaatctaca gatcttgcga tcaggccctt ggatatattt
     5881 ctatactggg caatctccga agcacttttc agtccctcac tatttgccag aaacatcata
     5941 actactatct cattaggagt gaaaccatat tccgatacag actggctgca cagcttctgg
     6001 tataccttat cgatttttac aaaacatgcc agacagcact cttcttcctg tctcattttt
     6061 tctcctggca tactggttac agactcattc ataacaacac ccttactaaa tcatatgaga
     6121 aaatttccgc actgtatact atggcagcta ttacaacgct tccaatagtt cattattgaa
     6181 ccgtttactt ttgaagtata tctcatagaa aagcacctgt caaccccgta tagaaaaaac
     6241 ccggaaaaag aaatcctttt ccgggtaatt attttttatg cttctggctt ttcaacctgt
     6301 gcaatttgtg acttctgcat aggaattctg cagttttttg ttgttgccga attcaacgat
     6361 aacggtatca tcagtcatat cgataataac tccataaaat ccgctgctgg ttaatatact
     6421 gtcaccgact gcaatactgg cgaacatctc ctgctgtctt tttttctctt tcttctgtgg
     6481 tctgatcgca ataaaataca tgaagccaaa gattactgca atataaagtc cccatcctac
     6541 catgctcatc gtaccgcctg ttgctaataa cataaccgtt tcctccttaa atatcgatct
     6601 gccgtctgcc tgtcctaaaa gggggcctta tgcctgggaa tcaccggcca tcatgccggc
     6661 cagtttcctc tccttatact ctccataacg gtgattctcg attgcttcgc gaatctcttc
     6721 catcattgta ttataaaaat acagattatg caagacacat aatctcatgc ccagcatttc
     6781 ttttgctttt aataaatgcc tgatgtaagc tctgctgtag gaacggcagg tggggcactg
     6841 gcacccttct tcaatcggct tatgatccag ttcaaatttg gaattaaata aatttaattt
     6901 tccatggttt gtatatacgt gaccgtgacg gccgtttctt gacggataaa cacagtcaaa
     6961 gaaatccacg ccccgatcaa cagcctccag gatattggcc ggagttccga ctcccatgag
     7021 gtaagtgggc ttattctcag gcagataagg caccgtctca tcaagaatcc ggtacatctc
     7081 cgagtggctc tctcctactg caagaccgcc cagagcatat ccatcaagat ccatggcaga
     7141 tatggttttg gcatgggcaa ttctgatatc ttcaaatgtt ccgccctgat taataccaaa
     7201 gagcagctga tctttattaa tggtatcagg cagctcattt aaccttgcca tctctttcct
     7261 gcacctctcc agccatctgg tggtacggtc cacactgttt tgcatatatt ccctggtagc
     7321 cggatgagga ggacattcat caaatgccat agcaatggta gatgccagat tggactggat
     7381 ctgcatgctc tcttccggac ccataaagat cttgtgtccg tcaatatggg actggaagta
     7441 cacaccctct tccttaatct ttctaagacc agtcagagaa aacacctgga agccgccaga
     7501 gtctgtaaga atggggcggt cccagttcat aaactggtga agaccgccaa actccttaat
     7561 taaccggtcg cctgtacgta catgaagatg ataggtattg gaaagttcca cctgggtttt
     7621 aatttccctg agatcatcgg tggacacagc gcctttaatg gctgctaccg ttcccacatt
     7681 cataaacacc ggtgtctgga ttgttccatg caccgtagtc acttccgccc gttttgcacg
     7741 tccgtctttt gcaatgattt tatagttcat ttacaattcc ttacttttat attttgcttt
     7801 tcgcagttgc tttcacacca gaattcttct tacccttatt cacagtcata atataccaca
     7861 gggatcctgt gatgcatacg gaagaatagg taccgcatac aatacccacc ataagcggaa
     7921 gggcaaactc ccgaatggat gaaactccca taataaacag aacaaatacc atgataaatg
     7981 ttgtaagaga ggtattaata cttctggtaa atgtctgagt gatacttaag ttaacgatct
     8041 cagcaagctc catcttactc tgagtcttta agttttcacg gatacggtca aaaataacaa
     8101 tggtagcgtt gatggaataa cctacaatcg taagcatgca ggcaataaat gtagagccta
     8161 cagaccattt taagattgca taaaaaagcg agtacaacaa gcacatcatg aaccagtgcc
     8221 agtaccgcac tgcttgcaaa ccggatatcc ttaaaccgga accagatata cagaagcata
     8281 cagatggtag ctataataac agccacaatt gcatcacgct tcatttcctg gctgattgct
     8341 cccggaaatg ctctctgcag tgatcttttc tgattctact ccaaaatgtt ctaccatgga
     8401 tttattcagt gcttctctct catccacagt taaggttctt gtcttaataa taacttcatt
     8461 ggtacctgct accttctgag tctgtacatc ggcatctttg gtaatctgct caaccaccgg
     8521 aactacatcg gaagagattt tttccagagt catgtcttca ttaaatgtaa catttgtgga
     8581 agtaccgcct ttaaactcca tgctgtaatt taaaatactt ccagtctggg accgattcac
     8641 tccaagccat gcaagaccaa taacaataac aatgagggag gcagaaaacc agatcatacg
     8701 ctttgaaaca aaatcgatgg gctttctgtc ctttttgata ccatacattt tttcattttc
     8761 aaatcccagt ttaaacagac tgtttaatac gaactttgtc acaaacagcg cagttatcat
     8821 ggaaagtacg ataccgattg caagtgtgga agcaaagcct tttactgtac cagatcctct
     8881 ccagaacagc acagctgctg caattaatgt tgtaacattt ccatcgatga tcgcagacag
     8941 cgctttatga aagccagcct cgatggcact ttttacattt tttccatatc caatctcttc
     9001 tttgatacgg gtaaagataa ttacgtttgc atccaccgcc ataccaatgg acagaataat
     9061 acctgcaata ccaggaagag taagagtcac ctcaaacgcc tctaacaaaa ttaagatcac
     9121 gcctacataa atagacagtg cgataacaga agcaactccg ggaagtaaat agacaagaat
     9181 cataaataca gccacaatgg caaatccgat tacacctgct tttaagctgg tattgatggc
     9241 ttcctgtccc agttttgcac ctactacatt ggaacgtaat tcttccagtt cgagagaaag
     9301 agatccaata cgaatggtag aagccagtgt ttccgcttct tcataagagc tcattccgct
     9361 gatctggcac tgaccctggg taattggttc ctgaacaacg gggtttgagt acatctttcc
     9421 gtcatagata atcgcaattc gtttcccaac gttggcagtg gttacatcac caaatacctt
     9481 tttccgtcat cagtaaacgt taaatctacc atatattgct tgatgccgtt attttcagta
     9541 ataacaggtt ttgcagtaga cacctggtta ccatttaaaa taacttttcc agcttcatct
     9601 gtaaatgtta aggaaccagg ttttccaagt tcttcaagaa ttgcattggc atctgaaacg
     9661 cctgggatat caacgttaat acggttgtca ccctcctgat atacctctgc ctcagtgctg
     9721 tagttttgaa ctctctgctg cagcttgtag atggtatcct tcatgtcctc ttcacttggt
     9781 ttttcttctt ttgcctgata ggtaatgctg acgccccccg ccagatcaag tccaagctta
     9841 atgtcaccca tggtagtata tccaaaataa ccgaataaac caaccatcac cagtgcaata
     9901 atcagcccta acaggccctt gcctttgtta cttttcatga cttttctcct tcacttttgg
     9961 attaaaacaa gtttaagtct gaaagctgaa actttcagtc ttattctcca gccaatgctg
    10021 ccttaatcat gatcgcacat tcaatccgtt tcttctgcat ctcgcagccg gtatcatacg
    10081 catccgtaat gcttccatga aaattatagg agttagctgc acagcccccg ctgcaataaa
    10141 accttgcgaa gcaatcccgg catttgtctt ttgcataaac gttgcaaagt ttaaattcat
    10201 cgcggatctg tgtgtttgtc acacctgtat ctacattgcc cagaagaaat tcttcttctc
    10261 cgacaaattg gtggcatgga tagaaatcac cccatggcgt aaccgccaga tattcggtcc
    10321 ctgaaccgca gccagacaat ctcttggcca cacagggtcc ctgagtcaga tcaatattaa
    10381 agtggaagaa attaaatcct tttccttcct tctgtctctt aatatactca acagccagct
    10441 tatcatactc ctctaaaata gccggaatat cttcctgtct gatagaataa tcctcttcat
    10501 cctgagccac aaccggttca atggacatgc tctcaaaccc aagatctgca aactccagca
    10561 catcttttga gaaatccata ttattccgtg taaacgtacc ccggatataa taatcctttt
    10621 cccctctcag ttttgcgaac ttctgaaatt taggaacaat cagctcatag cttcccttcc
    10681 cgttccggaa tggccgcatc tgatcattga cttccttgcg tccatcaaga ctcagcacca
    10741 cattgctcat ttcccgatta cagtattcca taatctcatc atttaaaagc acgccgttgg
    10801 tagtcatggt aaaacgaaag ttcttattat attctttctc ttttgagcgc ccgtattcaa
    10861 caagttgttt tacaacttcc cagttcatca acggttcgcc gccaaaaaag tccacttcca
    10921 gattcttacg gttgccggaa ttggcaatca gaaaatccag agccttctta ccaacctcaa
    10981 atgacatcag tgcacggcgt ccatgatact ccccttcttc cgcaaagcag tacttgcatg
    11041 caaggttgca gtcatgagca atatgtaagc aaagagcctt cacaacggtc tttctctttt
    11101 taaaatcaac cacataatca tggtaaatat ccttggtaaa cagttcccct tcatcgatca
    11161 gaaactgaat ttcttccaga gcctctctca cctcagcctc atcataggta cttaaaagct
    11221 ccaaaagcac tttctctttt gcttcctttg gaagcgctgc ggccttttcc atatccggca
    11281 ccaacggtgc tgcaatcttt acagcatcat acataaccgg atcaaccgaa tgaacagacc
    11341 cgctgttgac atccataata atatggaagc cattattaat atattgatgg atcacttgta
    11401 ttctccttaa ttaagattta aacccgtaat catatttagc agacaagcga agcaacccct
    11461 accgtctaac gaccgtaggg gcatctgctt atctgcctta tggctgtact atacagtttt
    11521 atactagcga ttgctgttct cgcagctctg gttacctact gtacaggatg ttttgcaagc
    11581 tgactgacag gaagtctggc actcaccgca gccgcctttt ttcatagatt cttttaatgt
    11641 actggaactt aatgttttta cgtgtttcat aaacttacac ctcctgtatt tgcctaattc
    11701 tttgagatta taccacatgt ttttaaccag tgcaagatga attgccccct taagaaggcg
    11761 ccgaaacatt tttttcaacc gccaatatat tcgaatatcc tccctgatgg acgaatatac
    11821 tgaaccagaa gacaagacat aaggagaaaa aacatggaaa aatcaaagct tcaggtcaca
    11881 cttagaaatc tgcttgtcac ctacatattg accggagtcc tgctggtgat cctggcctta
    11941 gcgctttata gattccggct gaaggaaggt cagatccggc tgggtgtcaa cgcagtatac
    12001 gttatcacct gtctctttgg agggattctc atggggaaga gcataaagca gaggagattc
    12061 ttctggggcc tgttactggg tcttttgtat ttccttgtgc tgctggcagt ttcctttatg
    12121 ctgaacagag ggattaacgg gtcgatgaat cagatactga ctactatggc gatctgcgcg
    12181 gctagtggga ctgcgggggg gatgcttagt tagtggggta gacgagatta gagatggagg
    12241 ggaatggggg gctggcggaa aatgaggagt ccggtccccg gatacgctca tggtttcgga
    12301 cgggataggt gtaagggcga gaaagcacaa aaataaggac accggcacca ttcgtcaggt
    12361 tttcttgatg aaaacccgac tcagggcgcc taaaaaacgg actttgtgag tccgtttttt
    12421 gtcctcattt ttgcacttcc tctccctaac acctatcgac gccctacaca aatcgccgta
    12481 tccggggacc ggtctcctca ttttctgttc aactttgatt ctccatctgg gaaaagacgt
    12541 cgcggacaaa aggtgaaata agcatattta cttcgttaaa atcgaagacg tggagtgttt
    12601 catttccaga ggggcctgcg gcgtcgaggg aaacaggaca gaccaagagg ggcggagacg
    12661 gtttggaggc ggggttagaa gttcttaggc cggagaggtg caaaaaacat gggcggaaat
    12721 tggcttcaaa gccaatttcc gaggaaaccc tgagcgcgaa tttctttcag aaattcgggt
    12781 gaagtgtttc cgatcccatg ttttttgtgc ctgtccggtc ttagaagttc tcccgccgaa
    12841 actctgtctc agtccctctt ggtctgtcct gtttcttcaa cccccagata cattctcact
    12901 ttatcaattc ggtttttatc taaggcttcc actaccagcc tgatatcacc gtaaactact
    12961 tcttctccct gctcgggtag acggtctagg agtccgatga ttaatccggc tatggaatcg
    13021 taatcctctg attccagttc caggccaagc ctgtcgttta aatcgtctag cttcatggag
    13081 ccttccacaa gatattcgtg gggggctact tctaccagct cgttctcttc gtcttcatcg
    13141 tattcgtccc ggatctctcc aacaatctcc tccagtaaat cttccagggt gatcatgccg
    13201 gctgtcgctc cgtattcgtc caggacaatc actacgttgt tacaggtctg gcgcatctct
    13261 atcatgagtt cagctgtttt ttgtactcat atgtatagag gggctctctc agaaaattac
    13321 ggatattgaa atccgtactg ttgtcggtta aaagcaggtc tttcatgttg atgattccaa
    13381 ttacattgtc attggtttct tcgaacacag gtattctggt gtacatctct tcacggaaaa
    13441 tatcgatcag ctcttcgtat gtggcattta catctactaa ggtcatgtca atacgaggta
    13501 tcatgatgtc cctggctacg gaatcgccga aatcaaatac attgttaatc atctttcttt
    13561 cttctgattc aattacgcct tcttcatggc ttacatctac gatggttctc agttcgtctt
    13621 ctgtaatgga atcctgcttt ttgttggggt tcacgtgaat gaaacgcaaa aagctggagg
    13681 aaagaatgtg tactacatag atgactggtg tcatgactgt cataaatgcg tagatgattt
    13741 ttgcatattt taaagcaatc gtttcggaat ataaggttga tatggtctta ggggagattt
    13801 ctccaaaaaa ccaatattac aagggtcaga atgccggttc caatgctgat cgccttattt
    13861 ccccatatac tcatgacaag tgtggtggac aaagaagagg cggttaaatt tgccacattg
    13921 tttccaacga gaattgcgct gagcatcttg ccctggtttt ccagtatctt tgtaagcgta
    13981 atggcattct tgttgcctgc ttctgccaga gttcttactc tgatccggtt caccgtcgta
    14041 agtgctgtct cagcggatga gaaaaatgct gataatgaaa ctaataaaat taacataagc
    14101 aactgtatat agtcactcga atccaaaaaa atcaactcct gtttttttat attttacgaa
    14161 tgattgtaca atagaaaaac ggctgtgtca agaatacagc cgtttttttt gattcagcgt
    14221 tctttgaagg cacgtatggt ttcaatgatt atgatgaggc cagcgcctaa aaagatgaag
    14281 agatcgccca ggttaaagac tacttttttc agcctgccgt actgaatact gaaatagtct
    14341 actacgtaat gacggaccag acggtcgtac agattgctga ttgcgcctcc gagggcaatg
    14401 gaaaaggcca gcttttctgc tgtctttcct ttgctttaag agacatgcca gcattcctcc
    14461 gatgaaggag gcaactgcca ggggaatcat ggaaacaagt tccggacggt cttttaaata
    14521 gccaaaggaa aagccgggat tgtgattctt gtatagaagg atcttaccgc cgcttttctc
    14581 taattcttta gggaagtctg attcgttttg ctgttctatg gcctgcttga tgaataagtc
    14641 gagagccgca aggataccta taataccgat atatagcatg tttcactctc ctttcttcta
    14701 tcctctcatc tgaatgagag ggcctccgtt tttgtctaag taagctctgg tgatgatcac
    14761 ggaaccgatg ttggggtctt tgggaatctc atacatgatg tccagcatga agctctctat
    14821 gatggcacgg agggctcttg caccggtctt ctttttcagt gcctcctcgg caatccactc
    14881 cagtgcttcg tcttcaaata ccagttttac ctcgtccagt tccaaaagct tctggtactg
    14941 ttttaatatg gcattcctag gctcgtttaa tacccggact aatagttctt tggttaatgt
    15001 ttccagggtg accgtgatgg ggagccgtcc aagaaactcg ggtatcatgc cgaatttttt
    15061 taaatcttcg ttggttacac gggagagtat gttggcatct ttgtcgtatt tgtcttttaa
    15121 ttcggaggaa aatcctatgg aggtcttttc tttgagacgc tctttgatga tatcttccag
    15181 atcagggaag gcaccgccgc agatgaacag gatgttctcg gtgcgtacgg tggtcatggg
    15241 ggtcatggca ttcttctggt tcgcgcctac agggacctct acagtacttc cttccagtag
    15301 ctttaataat tcctgctgaa cagactcgcc gcttacatct ctgctgctgg tattcttctt
    15361 ttttgcaatt ttgtcaattt catcaatgaa gatgattcca cgttctgccc gctcaacatc
    15421 gttatctgcg gcagatagaa gttttgatac tacactttca atgtcatcac cgatgtatcc
    15481 ggcctctgtt aaggaggtgg catctgcgat tgcaagaggg acgtctaaga gtctggctag
    15541 tgtttttacc agataggtct taccgctgcc ggttggtccg atcatgagaa tgttggattt
    15601 ctcgatttgg acggcatctt cgtcatttta ctgtgtctgc aaggtataca cgcttatagt
    15661 gattgtagac cgctacggat atggcttttt tcgcctgctc ctggccgatg atgtattcgt
    15721 caagcttctg acgaacggta tgaggggctg ggatgtcttt tcgctccaac tgctttttgg
    15781 gctctttgtc ggatctcttt ttgatttttt gttttttggg gatctccagg tctttgttca
    15841 ggcttcccag atcgttgagg tttaagttca tgtagggcat tccggggagc ttgcttaggt
    15901 caagacctcc ctgagtgacg gaatcaaagg ctttctgcat acagtcatgg cataaattca
    15961 tgcctcctgg catggatacc atggaacctg ccttgctttc tggtctgcgg catacgtaac
    16021 atattttttc gtattctgat tcgtcttcat ttttttcttt atcaatatca gagttttgga
    16081 tcttgttgtc ttccatcttc tcctccagaa aatctttatc gttcaaagta taatctcctt
    16141 ttgtctgtaa ttctatactg tatatcagat tattataaag catttaaaag agtcgtacaa
    16201 gaggagacag acagtttaga gttttttaat gaaatgaaaa aactcccgga ttcctctgag
    16261 gattccggga gtttaatttt ttatttgtta ttgctgatag gtgtctgctg gttttttgcc
    16321 cagtgtgatg tcaacgttac gctctacata ctggccattt tcaagagact gtacagtcag
    16381 agatactttt gttcctcctg catagtattt gagcatgctt gttaagtcat cataggtttt
    16441 aattccctgt ccgtcgaatt tggtgatgat gtctttttca cgaagatctg actgggaagc
    16501 tgctccgcct tctacaattt tgtagataaa tacaccctgt ggcataccaa gctgctggct
    16561 ggtggtggag tcaatgttct tgcactggat tcctaaataa ccctgatcat tgtctgcaac
    16621 ctgggttctg gtcttcttgg ttatcagacc gtctatgatt gtctgggctt tggagatggg
    16681 aatggcgtat cccatacctt ctacttctgt agaagaatat ttagctgagt tgatgccgat
    16741 tacttctccc tgcatattta aaagtgcgcc gccgctgtta cctgggttaa tggctgcatc
    16801 ggtctgaagc agatcacggt ttgttccgtc ttctgtctgt acagcacggt caagtgcact
    16861 gatataacct acggttacgg actggccgta tccaagtgca ttaccgatgg caataacgcc
    16921 ctgacctact tttaatgttt cggattttcc aagtgaggca atggctattt tggataatgt
    16981 gtcagaggag atatttttta atggaactgc tatcactgcc aagtcactgt gcgtcggttc
    17041 ctttaatggc tgcatctacg gctgtctggt cgataaaggt aacttttaac tccttggctc
    17101 cctgaactac gtggttgttg gtgacaatta aaagctcatc atcgtttttg ccaacaacaa
    17161 ttccggaacc gcttccttct ccctcctgct gcatggggcc aaaccatgtc tggctttcat
    17221 agaccacctt gcttgtaatg gcaactaccg atggcattgc tttgtcaacg atagaagaaa
    17281 cgtcattgat tgtggaaata cttgatgtat tggaagcggg aagtgagttg tttgctggtg
    17341 ttgtggggag ggtttccgca cggcttattt ctactgattt attttgagca taggagcctg
    17401 ctgcccagtt gattcccaca atggtgctgc cggctacgat tccaaagacc agagcacttc
    17461 cgacaactgc tgctgccttt tttccgaaat tgcctttttt ccgtttcttt ccttcttcct
    17521 cataaggggt ctggtccggt gttctctgat aacggtattc ctgataatgg ggaatggtgt
    17581 tctgagactg ttccttttcc ggttctggat ctctcattat aaaattggtt gttacggctt
    17641 catctttatt ggtttccggg tttacccggc ctgtttcaat attgtcattt tcgtcataca
    17701 taacatcaat ctcctttcat gtatgtttgt tatctcatct gataaacaaa gtctaccaat
    17761 gaaatgtgac cattctgtga taaatctata ttgaatatgt gaattgaaaa atccctgcaa
    17821 aaagagcttt tatgtaaagc gctgtgtgca gggattttgt tttttatttt aaatttaatt
    17881 gacaggaggt gcaggaacta caactgtatc tgtattgccc cctggagctg ttgctgctgt
    17941 ggtgggagcc gtatcggtct gctgtttcgt gggagtttca ccaggacctg tcgtctttgt
    18001 ttcctccggg aaagctgcct tggttgtctc gctggttcca ggtccagccg atgcagtagt
    18061 tgtctcagtg gttcctgagg ttgttggttt tgtttctccc ggttttccag tgcctttggt
    18121 ggtttcagaa ggcttggttt ctttttgtag gacctgtgac attttcagag ctttcagtag
    18181 tctttacagg gtttccgaat tcgtcagtgg catccacatt ttcctctttg ctggtctctt
    18241 ctgcctctgt actcttcgtc tcctttaccg ccggtttggt tttgtcttcg ccatcatacc
    18301 ccttatcagt gggcacatga tcaacgcttg ttccctgctt atacatgccg gaatcagccg
    18361 caatcttggc actgatcttt tttaccatat cggagggttc atagctgtcc ttgtcaaaaa
    18421 aggaatttat gcagctgtgc cacgtttgtt tccaatgtct gcggaattac acagtcacct
    18481 tttttaccta tggtcatatc gccgcgggaa tatgggaagc cgcctgtttc accaatgtga
    18541 tatttaccaa tatccaataa cagttcagta aaatcgctga atgttaaatt agagccgatc
    18601 tggtcaactt ccataagaag aattctgtta agcagaccca gatccgcttt ctttgccttt
    18661 tcaaaggatt tctgaattac aaggcgctga cgctctgttc ttgcaaagtc tgtatccatc
    18721 tttctgagtc tggcgtaggc cacagcctga acaccatcta aatgattgag accagctgat
    18781 tttaaatgaa cagaggggac tccggttttc tcaacagtct ctgtaataaa ggagttgata
    18841 taacggaatt ccgccttgct gatatcgata tccacgccgt ctaacatgtt aattccatct
    18901 gccacagact tccagttgaa ggtcacatac tctgtgacat ctaaatccag gtttctgtta
    18961 atcgctgcaa gtgcctgggc agcgccgccg tttgcatagg ctgcattaat tttattataa
    19021 gtatttcctt cattgatgtt taaatatgta tcacggaaaa tggatacaat ttttatttct
    19081 ccagtacctc tgtttatatt acaaagcata ataacatcgg cattggttcc tttacttaca
    19141 ttgccatcac ggctgtcaac accaaatact gcgatcgtac gatatccggt catatgcttc
    19201 ttctggtctg cagtcatcac ttcgttacgt acctgatttg cgttaaaatt atcgggtttc
    19261 tgaatagaac ccatgagtct cgccacatat gcataggaga aaataagtgc gagagtaaat
    19321 atttctgcaa ctgcaaggat tatgaattta cggatccgtc tcttcttttc tgtatgagca
    19381 gctaaccggc tggctgcagc ggccttctcc tgaggagaaa ttcttggctg ttgtctggaa
    19441 gcaccgtctc cgatcacgat ctgatctctc gcgggagttc ttccttcctc tttcgcggcc
    19501 cggcttctgc ggttttcctg ttccatggcc gttctggccc ggttctcttc cggctgcctt
    19561 gcaccagtcc tttgaggtct ggcagcatct tccggctgtc tgcgtgttgt gcctgccgat
    19621 gccggctgtc tgcctgctga tgattgtccc ttaaacatag gctgcccgct gctgctggca
    19681 gaatctggct tcgaatcaga accgcgtctt tcttttcttg tgctttcacg gtttaattca
    19741 tcatcaaaat catttctcat ttacttatcc tcatcctaat tgtgtcgtat ccgatatcag
    19801 tacgcatttt tattaataaa gcctttgaac atagttagga acaggatctt aatatcaaat
    19861 cccagtgtcc agttttcaat ataataaaga tcatgttcaa tccgttttgt aatggaagtg
    19921 tctccccgaa gcccgtttac ctgagcccag cctgtgattc cggggcgtac ctgatgctta
    19981 atcatgtacc ttgggatttc ctctttaaat ttttctacaa aaagaggacg ttcgggtctt
    20041 ggacccacca gactcatatc tccccttaac acattaagaa actgcggcat ctcatcgata
    20101 ctggtctttc tgataaaacg ccccaccggg gtaactctgg aatcgtgttt tgttgtccac
    20161 ttcatctttt cttctgaagg agcctgtacc accatggacc ggaatttgaa catatgaaat
    20221 gaccggttgt gaagcccgac tctctcctgc ttatagataa gaggaccggg agcagtaagc
    20281 ttgattaata tggcagtaag aagcataatc ggcgaaaaca ccaaaagagc aaaggctgcc
    20341 ccgaatatgt ctaccgcacg ctttaacatg gcgtttaccg ggtcagtcag cggcacacgc
    20401 cggatattga ccacaggaag cccctgaagg tcttcgatgt aaggccttgt gggaatcata
    20461 ttattataat caggtataaa tttggtgtga actcctgatt tctcacagga agccacaatc
    20521 cgttctaaat ccgcatattc gctgatgctt agggtgatcg caatttcatc aagggaattg
    20581 agggcaagta tctcatctaa gtcacttacc tttcctatga catggattcc tttaaactca
    20641 taaccccatt ctttcttatt gtcaagaatt cctttgatct gatagcccca ttcaggattc
    20701 atacgcaccc gttcaataaa accttccgct gcgcggctgt acccaatcag aagaatatgc
    20761 ttctgattgt atcctttggt acgcatggaa tgaagggcca tacggattaa atttcgctcc
    20821 gctgtctcca atatgacatt ggcagcaaag aaatagaata ccattctggt agaaaactca
    20881 ctgaaatacg ggttttttct taaccaggaa cagactgagg gtaaaaagca gaagccccag
    20941 cacgttggct tttaagatat tggtaaactc gtatcgcctt tcctgaaccc gcttcggtgc
    21001 atacagctgg aaaatgccgt agaggagcag ataagtcggc aaaatcagga gaagcgccgc
    21061 aaaatagtac tgaggtggca gaacctgctt ataggggctg aataaccagt tacccagtaa
    21121 aagaagcagc caggcaatca cataagacag aatgataacc agtccatcca gtactacatg
    21181 aaacccatta aatttttttt gattatcttt aatcatagca gcaaaacctt cctacttgca
    21241 tgactccata ctcttccatg ataatttccc gtttattata catgatatgt caatatgatg
    21301 ccattaaaat attcttaaat tgacctgtca atttttagtt tccttttcat aaattcccaa
    21361 acatagagaa atgtgcccaa aatcagctct ccctcaattc ttatataatt accaaggcgg
    21421 gacatttgaa acctgacttt ctttgttttt ttcaaagttt tcagcccttc cttcactcct
    21481 tccatataat cagaagcgaa gccaatccga cggaaaaaca tatattttac tgccattccg
    21541 gccagaatgg gtagaaagtt caggattaac tgcagcagag gcatattttt ataattcaga
    21601 taaagattat ttcttgcagc cagctttact ttaaaggaat tgtatttgga accgctggtt
    21661 ccactcccca
//
