LOCUS       NZ_CP070896            39895 bp    DNA     circular CON 17-JUN-2024
DEFINITION  Lacrimispora xylanisolvens strain ASCUSBR21 chromosome, complete
            genome.
ACCESSION   NZ_CP070896
VERSION     NZ_CP070896.1
KEYWORDS    RefSeq.
SOURCE      Lacrimispora xylanisolvens
  ORGANISM  Lacrimispora xylanisolvens
            Bacteria; Bacillota; Clostridia; Lachnospirales; Lachnospiraceae;
            Lacrimispora.
REFERENCE   1  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Hungatella xylanolytica ASCUSBR21
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5633035)
  AUTHORS   Gaffney,J.R. and Embree,M.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) R&D, Ascus Biosciences, 6450 Lusk Blvd E209,
            San Diego, CA 92121, USA
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 09-MAY-2019
            Assembly Method                   :: Canu v. 2.1.1
            Assembly Name :: Hungatella xylanolytica ASCUSBR21
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 100.0x
            Sequencing Technology :: Illumina MiSeq; Oxford Nanopore MinION
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_017084465.1-RS_2024_06_17
            Annotation Date                   :: 06/17/2024 10:45:42
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 6,443
            CDSs (total)                      :: 6,353
            Genes (coding)                    :: 5,667
            CDSs (with protein)               :: 5,667
            Genes (RNA)                       :: 90
            rRNAs                             :: 6, 6, 6 (5S, 16S, 23S)
            complete rRNAs                    :: 6, 6, 6 (5S, 16S, 23S)
            tRNAs                             :: 68
            ncRNAs                            :: 4
            Pseudo Genes (total)              :: 686
            CDSs (without protein)            :: 686
            Pseudo Genes (ambiguous residues) :: 0 of 686
            Pseudo Genes (frameshifted)       :: 599 of 686
            Pseudo Genes (incomplete)         :: 95 of 686
            Pseudo Genes (internal stop)      :: 24 of 686
            Pseudo Genes (multiple problems)  :: 30 of 686
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 03:11:21
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 1643565
            Orig. end                         :: 1683460
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070896.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..39895
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /candidate_cluster_numbers="3"
                     /contig_edge="False"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-i"
                     /region_number="5"
                     /rules="(TIGR04223 or AgrB)"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..39895
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="neighbouring"
                     /product="cyclic-lactone-autoinducer"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     cand_cluster    1..23462
                     /candidate_cluster_number="2"
                     /contig_edge="False"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..23462
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:13462]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..13462
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="1"
     misc_feature    709..722
                     /note="TFBS match to RpoN, Regulator of nitrogen
                     assimilation and virulence, confidence: medium, score:
                     16.07"
                     /tool="antismash"
     misc_feature    863..878
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: weak, score: 20.41"
                     /tool="antismash"
     gene            complement(1259..1804)
                     /locus_tag="JWH23_RS09160"
     CDS             complement(1259..1804)
                     /GO_process="GO:0008643 - carbohydrate transport [Evidence
                     IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.4"
                     /locus_tag="JWH23_RS09160"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="carbohydrate ABC transporter permease"
                     /protein_id="WP_349772991.1"
                     /transl_table=11
                     /translation="MNFIIRTCFLYTILFMTSLPITAVMVPVYKMFLTVGLYDKIGGLI
                     LFLTATSMPYGIWLMKNFMDNVPVELEEAAWVDGASAFDSLRKIIAPLMFPGICVVFIF
                     TFSGSWGNFFVPYILLQTLDKFPASVTLYQFFGQHGMVIYGQLAAYSAVYAVPSIVLYV
                     LSQNYMSKGFNMAGAAKG"
     gene            complement(1716..2081)
                     /locus_tag="JWH23_RS31310"
     CDS             complement(1716..2081)
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1069: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS31310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_349772992.1"
                     /transl_table=11
                     /translation="MYWKFRKTIPYLVLTILAVIFALPLLWILLASFDANASQAVKMPS
                     QWTMENYKTILLNQANQRAFGNGLLISLGQSVLVVLIAGFAAYPLSRYELHYKNLFFIY
                     DFIYDLTSHYSSDGSRL"
     gene            complement(2098..2973)
                     /locus_tag="JWH23_RS09165"
     CDS             complement(2098..2973)
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1067: putative ABC
                     transporter permease protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012738.4"
                     /locus_tag="JWH23_RS09165"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sugar ABC transporter permease"
                     /protein_id="WP_277408868.1"
                     /transl_table=11
                     /translation="MNKKQSSLLEEARKSVLLMPSVLLLLVFFVTPILLTVYYSFTNLA
                     LSGENARQLKFIGLSNYFTMFKDRTVRISIGNTLVFLLGSLIGQQVLGFIIALNMRNKN
                     RIFRGIVGPIFLAGWIMPEVVVALCCSTFFGDSGTLNQIFSFFHLPQVEFLFAIPMLTV
                     ILANIWHGTAFSMMNFQSALDGVPADIEEAARVDGAGPFQTMIRIVLPCIKNTIATNTM
                     LNTLSTLGVFGLIYMMTGGGPGTKNPDSSHLYVQTGIYFPAAGIWNCHIHDPPGDWNCS
                     ERILYQNYEK"
     gene            complement(3051..4472)
                     /locus_tag="JWH23_RS09170"
     CDS             complement(3051..4472)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF024808.4"
                     /locus_tag="JWH23_RS09170"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_277408869.1"
                     /transl_table=11
                     /translation="MKKMKRIQAAALASVMALSLTACQGAGGKSETQGGSTAAATQKET
                     EKPAGQTTAAAGKTKISITFRNDGSDVLKKWFEHAYETYDKKDSIELDIAPITASEGDY
                     FAKVALALQSADTAPDIVCEDTFQLPSDVAAGYLTNLSSYLKDYKEWNDGTFYGALVDG
                     VTYDDGSVYGIPYSTDTRGLWYNKDVFAAAGLDTNWQPKTWQDVLDTCKVIKEKCPDVV
                     PFWCNSGVATGEATSMQTYEMLLYGTGEQLLDNNKWIVKSDNILKSLNFVSTIYKDGYG
                     PSLSKVLNGEAGNIASREYLPKGKLAITLDGYWMTGNYKETGAAPWPEYKDKLGIAAMP
                     TSEGQAPGNVTMSGGWALSIPNLSDQKDAAMDFIKHCMSYDVYLDTIIAQGNIATRTDI
                     AKDASYSSQPFMETCTGFLSGAFYRPRNSQYTTVTTHIQTMVESVVSGTSPEDAMAQYK
                     SDVTNSVGEENVVEK"
     gene            complement(4573..5829)
                     /locus_tag="JWH23_RS09175"
     CDS             complement(4573..5829)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1143: sugar-binding lipoprotein"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013697.4"
                     /locus_tag="JWH23_RS09175"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="extracellular solute-binding protein"
                     /protein_id="WP_277408870.1"
                     /transl_table=11
                     /translation="MNRRIGKLLILAWTVVFLLLMGVLVNFSRETNVVHRPGNAEKKLV
                     IMAVYEEDESDEYLKKILDEYSAIPGNPKVVTEYVAQSAFQKQLCLYKDQNSLPDLIIC
                     DSVMTPALQSMDILKDLSDYMTGERTSRFLKHAYGSCVVNGICYGVPFTSNPYVVFYNK
                     DHLARYKKEIPDNMDDFYNLCRETKSLGTYSFGIAVKNKEDIASSFLQLVYSAGGNLRG
                     LDSDNSLKLYEILGKMRDEGIIAQDVINWNQKDLMQAFSSGYVKIAVAKLSSMSLLEHS
                     DSQINYEIAEIPYIQKQTFLFQGDMIGVTETADETEALKLLDYITSPEVAESYYKNTYS
                     LSVRTDVCVNPGKVRGLSDAFVERERNQSVLKSTYSTWFIISDSIAGAMSDFFGDKSMT
                     PQAVGARLQGEIRSAILER"
     gene            complement(5833..7254)
                     /locus_tag="JWH23_RS09180"
     CDS             complement(5833..7254)
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_function="GO:0043565 - sequence-specific DNA binding
                     [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: protein motif:HMM:NF024242.4"
                     /locus_tag="JWH23_RS09180"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="helix-turn-helix domain-containing protein"
                     /protein_id="WP_277408871.1"
                     /transl_table=11
                     /translation="MEGASDGETGLLEALRLQPDVVITDINMPQMNGLVMIERMRKEGC
                     EAAAVVLTGYSEFEYAQKAIQLSVVEYLLKPLSVEDIMSVLETVENRLSKTRAKTVSPQ
                     QLLFSLLTGESKEEAMRQFVSEIRYQNGQEISLFLIQSESILEDTTKQMAELLKDSLET
                     NCLTSFYTFLLPYERQILVMILDGQSVRYLKNLFQTRILKELKEKGEFLISFESIYGIG
                     ELKDVIRQMQDSLSYSFLFSESCIMDQELIKKLAFERIDYPEYLEHGVKREIKIGNQDG
                     IRRMAGLFEEQVILRRERPETIKNHTVRFVMAILDTARELMKEKDIDGLYQYLLNDMMK
                     TGIREVFLNNYWKIIGMVTDERDSGALTDNGMILNVIGFIRQNYAREISLTDAAELVGI
                     TPEYLSKLFTKEMGINFTAFLGEFRISTAKKLLASGKYKIYEVAELVGFKDTKYFNKVF
                     RSIAGVCPSDYRKGV"
     gene            complement(7361..7957)
                     /locus_tag="JWH23_RS09185"
     CDS             complement(7361..7957)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0000155 - phosphorelay sensor kinase
                     activity [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014567.4"
                     /locus_tag="JWH23_RS09185"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="histidine kinase"
                     /protein_id="WP_349773190.1"
                     /transl_table=11
                     /translation="MEAQINPHFLYNTLDAINWIAIENEQFLISKMLKNLANILRYSIH
                     KSNGVVTVRSETEYLKQYIFLQQQRFSFSFHCIMDIEEEVMDLKMHKLLFQPLIENSIN
                     HGFPGKSGEDLITITIRKKGERHLIFEVKDNGKGMDSELIHELNHYDYSASSLEGSIGV
                     RNVIMRIKYYYGDEGHFEIVSDENGTTVRAEILFE"
     gene            complement(7923..9101)
                     /locus_tag="JWH23_RS09190"
     CDS             complement(7923..9101)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF012876.4"
                     /locus_tag="JWH23_RS09190"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing protein"
                     /protein_id="WP_277408872.1"
                     /transl_table=11
                     /translation="MIRKLLNRYKSYSIATLIILLAGSIVPLMIMETITCMIAASTLKR
                     QTDILMESNMKLSQKGLEDYFSQYDSIIMSIYTENQYALKLEKLNVWDSRNYYLIKKEL
                     EDDLENISYLHPEILGIAVVTQKKECIGYDSVTNSIMNSFCFPDRDKSWLEVADETFLN
                     TRTVYSDMINRKEDNGTSRNIIYLGHRIADINNYRQGTVGSILICLDEERIRETYSQED
                     KQDRTVSFLCDTNGIIISSNRAELIGTRIEPATKASFSSIYTKPVLNGQYVLVTIRDNR
                     ELLKDFKYIFEVIILLTILIIITSILIMLRFAESLQVRVEKITSAMDRAYKGDYTVQIS
                     HSWQDEFGTIARHFNHMVTKIDQSGRMERSSFKREECGAKGTGSTDQSPLSL"
     gene            complement(9263..9886)
                     /locus_tag="JWH23_RS09195"
     CDS             complement(9263..9886)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_009296043.1"
                     /locus_tag="JWH23_RS09195"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="undecaprenyl diphosphate synthase family protein"
                     /protein_id="WP_277408873.1"
                     /transl_table=11
                     /translation="MRIPKHIGIIPDGNRRWAVENGIKKEEGYDKGISPGMTLYHLCKD
                     LGVEEMTFYGFTADNTKRPSVQREAFSKACVRAVEVLSKENAQLLVLGKTSSAMFPDEL
                     KPYTKRVCFGTGGMKINFLINYSWEWDLGLSDGTIGPELKTSDVSRMDLIIRWGGRRRL
                     SGFLPVQSVYSDLYVVDDYWPDFKTDHVYKALEWYSRQDVTLGG"
     gene            complement(10001..10138)
                     /locus_tag="JWH23_RS09200"
     CDS             complement(10001..10138)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_004055627.1"
                     /locus_tag="JWH23_RS09200"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="cyclic lactone autoinducer peptide"
                     /protein_id="WP_170819707.1"
                     /sec_met_domain="TIGR04223 (E-value: 9.2e-09, bitscore:
                     33.8, seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGKSNIAAKFMEQVARKSVELASESRCMYIYHQPKMPDLKKFKK
                     "
     misc_feature    10279..10292
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: medium, score: 23.23"
                     /tool="antismash"
     misc_feature    10280..10293
                     /note="TFBS match to MogR, Repressor of flagellar motility
                     genes, confidence: strong, score: 24.21"
                     /tool="antismash"
     misc_feature    10280..10296
                     /note="TFBS match to ZuR_variant_2, Zinc-responsive
                     repressor, confidence: weak, score: 24.87"
                     /tool="antismash"
     misc_feature    complement(10495..10511)
                     /note="TFBS match to HexR, Glucose-responsive regulator,
                     confidence: weak, score: 25.3"
                     /tool="antismash"
     gene            10813..11553
                     /locus_tag="JWH23_RS09205"
     CDS             10813..11553
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_016283191.1"
                     /locus_tag="JWH23_RS09205"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="LytTR family DNA-binding domain-containing
                     protein"
                     /protein_id="WP_277408874.1"
                     /transl_table=11
                     /translation="MLRIAICDDDVLFTGMLENLIKEEALTNGIEIEVDVFFDGSMLTK
                     YVHLGNLFDLIFLDIEMSQQNGIEAARRIREIDKTALLIYISGYDQYLKELFEVEPFRF
                     LSKPLDTAKFSRYFKEAYERINENNVYFQFNFNKEIKKVALKDVVYFESRNRVVYIYLK
                     DGREEFFYGKLNDVENELAGNKQRYLRIHQSYLVNYDYVSTMNFSSLVIENGGKSTTLQ
                     ISEDRQKKIRKQLCDLASKKAGGK"
     gene            11555..12853
                     /locus_tag="JWH23_RS09210"
     CDS             11555..12853
                     /EC_number="2.7.13.3"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF025854.4"
                     /locus_tag="JWH23_RS09210"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="sensor histidine kinase"
                     /protein_id="WP_277408875.1"
                     /transl_table=11
                     /translation="MKILSTTVVSPFLSLFYILVIRKCINAFFAPSWKKTTTYIIWIAY
                     YLFQLFLGIGSGIPPTLTLFLNMVFVFLATSISYSESYKKCALFSFLICAIWMLVEIII
                     HMILNMMNLDDKAGLSGAIISKIVMMVFAIVTGHCLQHKSIGDISLRYMAILLMVPAGS
                     IYIMHNIFLISSTAEDEVLFSFISGILLLFINYIIFEVFESLAASSEYQKKTLLYEQQL
                     ELCSRQAEEREIQNTEIRLLRHDMKQHLVSILGMVNSGKNEEAATYLTSFLEKGTSKKI
                     NEISHSGNIVVDSLVNYKSSIARKQNIEFCTNIFIPPVMPFQNGNLTIILGNLLENALE
                     ACRQMNSGHPKIDLEMSYQKGILSIVVWNTFEGDRYTDGQKHFLTTKKNPAHHGLGLFS
                     IEQAVAACNGEAITQVEGNIFKAVVILYQEPEK"
     gene            12881..13462
                     /locus_tag="JWH23_RS09215"
     CDS             12881..13462
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016526.4"
                     /locus_tag="JWH23_RS09215"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="accessory gene regulator B family protein"
                     /protein_id="WP_277408876.1"
                     /sec_met_domain="AgrB (E-value: 7.2e-34, bitscore: 115.3,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MERLSIVLTNYILKKEVISKEDYEVYLYGFQSFLELFLNLVCSLC
                     IAFFIHMEVECLLFFLLFIPLRSFNGGLHLKSYFSCLVFSCATMTVILLIVKYYSLNAP
                     VSFLLYLVFMVLIKLTGAVDHPNRPVDTDENQTLTHKTDRTLFISFLAALCFLFLNLEN
                     YIFLEALIYLLVFITLILSKINGKNRQQVE"
     gene            complement(13468..13932)
                     /locus_tag="JWH23_RS09220"
     CDS             complement(13468..13932)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF016961.4"
                     /locus_tag="JWH23_RS09220"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="phage holin family protein"
                     /protein_id="WP_104436652.1"
                     /transl_table=11
                     /translation="MEKKLDLEKSAMGIISAWIMDQFGLLFPAISLLTILMITDYISGM
                     LASKKEALDNPDNNQYGWNSRKSRIGIYKKSSYIFIILAAVSTDYVIYKFSTEIGIKFE
                     HKTIFGLLVSVWLIINELISILENAGRMGARMPEFLQKVLTELRGKIDKD"
     cand_cluster    13766..39895
                     /candidate_cluster_number="3"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="2"
                     /tool="antismash"
     protocluster    13766..39895
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[23765:29895](-)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      complement(23766..29895)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="2"
     gene            complement(13960..14499)
                     /locus_tag="JWH23_RS09225"
     CDS             complement(13960..14499)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09225"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="sigma-70 family RNA polymerase sigma factor"
                     /protein_id="WP_104436653.1"
                     /transl_table=11
                     /translation="MGESVHVIIEEIKKGNKEKFLLIIDKMTPLINKYVRLLYKDEKED
                     MHSEFVLSLLEAINSMQYYKEDGQCVYFLSRALKNKFLEQYKKSKQHFDAEASVEDEFF
                     TEISMDQPVYDDWLFHEDLKTMLLKTEGKQAVILWDIVFHEESDAVIAERHSVSRQYVN
                     RVRRNFYNLLKENYYK"
     misc_feature    14478..14489
                     /note="TFBS match to AfsR, Pleiotropic regulatory for
                     antibiotic production, confidence: medium, score: 19.28"
                     /tool="antismash"
     gene            complement(14844..15380)
                     /locus_tag="JWH23_RS09230"
     CDS             complement(14844..15380)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09230"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277408877.1"
                     /transl_table=11
                     /translation="MNKNLFLFCFLILSLTGCADSNMTGGTVLQPDENQVSNMVQEPVA
                     LAEEEINWQTAYREIIDQGGGHLPDPYKLRGEDGLNSSFYLGIHDFNEDGIPELILGDG
                     ISISVYTYLNHGLEKVADLYEPEGWYMIHELYIQNNCLILVSNGSDGCGYVGFTYGKAH
                     ILLVHMMIPVRISRF"
     gene            complement(15575..16369)
                     /locus_tag="JWH23_RS09235"
     CDS             complement(15575..16369)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09235"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277408878.1"
                     /transl_table=11
                     /translation="MNVYKGGAGFLTRERSIRHGSSICIFIFIVHLLCFCYYSTAFANS
                     AEPPGFTIIVLNSPEKMSLSLKMSDHDVTYLRVVEGERKGWEKYYRLYYNHSSSQVKDL
                     KDAVLVVQSNNKSFQCALPEETFRTYSNILTLDMESETLTMGQAPLRVPALVAMRVLLT
                     MLIEGIIFLLFGFRQKRSWLVFTAVNLITQAGLNAMLTGPDLGNYWIYGYLFVEIVVLA
                     AELIAFLNLVKEFRKGRVALYVITANIASLIIGGMVITYLPV"
     gene            16550..17251
                     /locus_tag="JWH23_RS09240"
     CDS             16550..17251
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_003470164.1"
                     /locus_tag="JWH23_RS09240"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic protection ABC transporter
                     ATP-binding protein"
                     /protein_id="WP_277409822.1"
                     /transl_table=11
                     /translation="MHEYMLKTNHISKKFKKTYAINDLSMSVRKNSVYGLLGPNGAGKS
                     TLLKMITGIITPTSGEIIFDNHPWSRKDLLRIGSLIESPPLYENLTAFENLKVRATLLG
                     IPTDKCMEVLERMDLMDTENKQIANFSLGMKQRLGIALALLNDPELLVLDEPTNGLDPF
                     GMEDLRKMIRTFAVSGISVIVSSHILSEIQQVADDIGILNNGSLLFQDKIDANENLEQL
                     FMDIIRKERAS"
     gene            17251..18012
                     /locus_tag="JWH23_RS09245"
     CDS             17251..18012
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014357727.1"
                     /locus_tag="JWH23_RS09245"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic immunity ABC transporter MutE/EpiE
                     family permease subunit"
                     /protein_id="WP_277408879.1"
                     /transl_table=11
                     /translation="MLQTYLAAENLKFKRTLFRKLILYIPAALILIAVIFLSVGIGLGG
                     FSASIVCNWCVPIASLSIVILCHLVNNKEQKHNYRTIYSLPIDLKNTFISKTILIALNL
                     LLISLLLSCISIISEYMMSGVLSAFKHTGYYVLGYCLLWLTLLWQIPFCLFLDQKAGFV
                     GSMIINLIFTGLGGLFLSLSPIFWFIPYSWTARFMITLFGVLPNGLLVQGGTRQILSLG
                     QSSLLVVVSMLTAVVLTFLFAHWYRGQVYRN"
     misc_feature    complement(18177..18197)
                     /note="TFBS match to MntR, Manganese transport regulator,
                     confidence: weak, score: 24.85"
                     /tool="antismash"
     misc_feature    complement(18631..18645)
                     /note="TFBS match to IolR, Regulator of the inositol
                     catabolism, confidence: medium, score: 19.63"
                     /tool="antismash"
     gene            18757..19432
                     /locus_tag="JWH23_RS09250"
                     /pseudo=""
     CDS             18757..19432
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_process="GO:0000160 - phosphorelay signal transduction
                     system [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1008: response
                     regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014357729.1"
                     /locus_tag="JWH23_RS09250"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="response regulator transcription factor"
                     /pseudo=""
                     /transl_table=11
                     /translation="MPKLLVIDDDLDMLALVRTALEKDGYQVDTEANAASLQPARCRLY
                     DLLLLDVMMPGEDGFSFCRRIRTEVDCPILFLTAKAEDSALVQGFGLGADDYIKKPFSI
                     AELRARVSAHLRREVRQPTHILRRGIVHFDIQAKNSICW"
     gene            19408..20736
                     /locus_tag="JWH23_RS09255"
     CDS             19408..20736
                     /GO_function="GO:0000156 - phosphorelay response regulator
                     activity [Evidence IEA]"
                     /GO_function="GO:0004673 - protein histidine kinase
                     activity [Evidence IEA]"
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_process="GO:0007165 - signal transduction [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1003: sensor
                     histidine kinase"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_014357730.1"
                     /locus_tag="JWH23_RS09255"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HAMP domain-containing sensor histidine kinase"
                     /protein_id="WP_277408880.1"
                     /transl_table=11
                     /translation="MAKKRRSVSLSFVLLRFGIIMVGCMLLCCLLWYVLFIRLVKIGFF
                     YNSYTSTRQIEQMLAGDPETFVSPGDDFLAEYALFDQNGKVLESNIKGRKLEKLTSLLY
                     EDAYNMRVAKHTYGDGSTIIIRYYFRSEFANPVLRSALPPFEYMWLASLGAALVLCLLF
                     NTLWLRKRLAAKLKLFGEVSRKVGEQELDFTIPYAGIREYDQALDAMEHMRDALYNSLS
                     SQWAAQQEREAEIAALAHDLKTPLTLVGGNAELLLDEELPESSRRMVETIATSNERARQ
                     YVTSFLEASAGEEEAFKSNSLSELFDQLISNTTAIAESRGVCMKVQNDLNGFANIQKDH
                     LLRALGNVVQNAIEHSPVGGNVYLTGSMADGGWQVTVCDEGPGFSKAALQHATERLWRG
                     DTARGADGHNGLGLWFAAQVVKTHEGQLYLSNTKSGGVVTVKL"
     gene            20841..21071
                     /locus_tag="JWH23_RS09260"
     CDS             20841..21071
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF042545.2"
                     /locus_tag="JWH23_RS09260"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="HTH domain-containing protein"
                     /protein_id="WP_277408881.1"
                     /transl_table=11
                     /translation="MGGKRITPAHRNKDFSKEEIEILSRNPNVKSVTAKQINYTDEFKM
                     RFLEQYQTGKMPLDIFIEAGFDQKTYWSRAN"
     gene            <21232..21366
                     /locus_tag="JWH23_RS09265"
                     /pseudo=""
     CDS             <21232..21366
                     /GO_process="GO:0015074 - DNA integration [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_076611939.1"
                     /locus_tag="JWH23_RS09265"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="IS3 family transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="TFWDLKDEIDEYMEYYNNYRYQWELKQMSPDEYYTYLLTGFMPY"
     misc_feature    complement(21276..21289)
                     /note="TFBS match to PerR, Peroxide regulator, confidence:
                     weak, score: 23.46"
                     /tool="antismash"
     gene            complement(21595..22083)
                     /locus_tag="JWH23_RS09270"
     CDS             complement(21595..22083)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09270"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277408882.1"
                     /transl_table=11
                     /translation="MFYATDGMINIPMKTTDTVSQIPVSAKLTVQGTNISIRDFPDNVD
                     GDILRKLSTGSNITATSRITVNGTPWFYIGNKSWISGNYVQGWVKDYNDNKRWWYLEKN
                     YSYPSKTWKTISGKDYCFGKDSYLFVSCYIKSEVGNTYYWVDDDGVWLTQYNTSSPRP"
     gene            complement(22097..22519)
                     /locus_tag="JWH23_RS09275"
     CDS             complement(22097..22519)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF013152.4"
                     /locus_tag="JWH23_RS09275"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lysozyme"
                     /protein_id="WP_277408883.1"
                     /transl_table=11
                     /translation="MNVSTTGKNFIKSFEKYRLDVYDDGFGFLTVGYGHKVVATDNLKE
                     GDIITASRATTLFNADILTVETGINKHPKVSKFTQAQYDAVASLTFNAGTEYITNSKND
                     LYKALNKSIFVKSEVVKGFTVTIAGGIKTIGLSKAT"
     gene            complement(22644..23513)
                     /locus_tag="JWH23_RS09280"
     CDS             complement(22644..23513)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09280"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277408884.1"
                     /transl_table=11
                     /translation="MIRTKSVKQSALIMVSFIVCIISMGCTKTEMTKQEQTSTDQLTAV
                     SETEALTTEKETYTETTMEEPIRNNTHNIFKGTIGESEVQMNIRREGDSLTASYITRTD
                     DERTLRGEMKSPTEFELNDNEGGYLKGTVYDGNLKGTGNISGKDVTISMYLSTFMPIGY
                     DHDDYYSGDRIMSRQMTSTEVENFAKQIKESITDKEKFIKLFRYPLDIRVNKKVIPVQN
                     EDEMSDQIDTLFAETDFREQIETMYTKYLFTNYQGVCVENGILWFDKDNNGDFKIWSLN
                     YRDSNHLN"
     gene            complement(23766..25037)
                     /locus_tag="JWH23_RS09285"
     CDS             complement(23766..25037)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF017000.4"
                     /locus_tag="JWH23_RS09285"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_277408885.1"
                     /sec_met_domain="LANC_like (E-value: 9.8e-66, bitscore:
                     220.4, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLPNEKKRELDHFIINISKKLSDADYVQEIFATNNTEYRCTSVA
                     VSYPALCILFSELQLNFPDYDFDKYAHKYLEIVNDYMGKNNIYDISLFDGLCGVGYAAH
                     CMSDHGKRYQSFIKSLNEYIVDIAESNILKYKELPLNELFYDIMYGLTGTANYLLNFKS
                     QPNVKETLLHILQYLTDICKAGDDNIPRFAIRSNESQLFPLENSPEIGYINLGVAHGIP
                     GILLILCKSYESGVYVQDQLEAIKYLSEFIYNSCIKDSDDIFWETQKILGMEQEKAVPS
                     RDAWCYGTPGVAYSLLIASKILENDEMSKLAIDSMKLSLKRMRQVISPTFCHGLSGLCC
                     LTRKFYEYTDDNFFYEVYMKILDHLLESYSDQYPFGFKDTEIEEGHIVNKDEIGLLTGT
                     SGVILTILSCYQPVKTQWDSIFLL"
     gene            complement(25040..26731)
                     /locus_tag="JWH23_RS09290"
     CDS             complement(25040..26731)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1288: ABC
                     transporter related protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: protein motif:HMM:NF012869.4"
                     /locus_tag="JWH23_RS09290"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /protein_id="WP_349773191.1"
                     /transl_table=11
                     /translation="MFVLTIIINIIAGIVPVISVNIFGSLINAISAKDLNLSLKILAIY
                     IGISFVSGMIISFKTFLFTKFQFLLDYELINRLLDKCAIMSLEEFENSDIQDQLQHILS
                     QVGFRPYNIFTTTLTLVTSITTILSSVYIMLTWRPLSVFLIIVPAFAFSIFYLSISKRE
                     FQTEERNAKKARSIWYYEFLLTKDQSFKEVKIFNLARHIIKRHNDLKQSVINENLYNTK
                     VRLIISVVFDFVDQICMAVLMILIIFSVIAGEILIGNAVALLRIINMMFDSFNSIMNII
                     YSINQNSLYMSKLINFLNKPGNGNSEETYKLNDLNQIEINNLTFAYPETDKIVLQNINI
                     KINKNQRVALFGRNGSGKSTLIKLLLGYYLVEDDMIKMNGVPLNKVNIDSLHKLTGILF
                     QDYCKYELSVKDNVGFGNIDEIDNEAQIRESLEEAGIDFLPPDLNQQLGKWFSDGTQLS
                     GGQWQRVALARCFFKKAQMYILDEPNAALDKMGEKKIMNTFFELTKNKIGVFISHKIAH
                     VMLADKIIYLDEGKIVAEGTHEELLKTCPSYKEIYDLEFDIPQNGG"
     gene            complement(26839..28449)
                     /locus_tag="JWH23_RS09295"
     CDS             complement(26839..28449)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:TIGR03891.1"
                     /locus_tag="JWH23_RS09295"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_277409824.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 6.4e-30, bitscore:
                     102.4, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 8.3e-27, bitscore:
                     93.1, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKSYGDECQVCEFTYLPDSLYSANVIRNMHGSTYETSFGTTNSK
                     DQAFKLKLNEILVEFKNNKLYLKSAVNNKRIIPTSTNMFNPQLKPRILRFIDEISSDGI
                     RFYNKPWQYLMEKFAYLPTIRYKNFVLEQEKWIIKIGDLGLTKHYDFAEFKNKFTEYIN
                     SRNIPLWVDAVDADKKLLLNLKEDRCLSVLQKLLEKSETVVERYHIESEHPVKLNDSSY
                     CCELVIPLILAQDATPHKTNDFDITRNYGNARYKEPLDEWLYFKIYGIEEYADYLLGEA
                     LYAPLQNLLDNKEIDSYFFIQYKDPDLHLRLRLKADNTRLMMVLPKMLDILSQLMKKSL
                     ISNYSINCYELELERYGGYDLMNYAHEVFFKDSIAIQTIIYEKNNHNIKVTDELLASVI
                     IFFHMQTFNLSFEDMFVFLNCENPTKSYQKEFKKHKETYVDFVIKYLYHETLDPEIEFI
                     LKLLSVKQESMIEYLNRIEKYYPDNKAVKLSILDSLLHMNMNRLFGPNTELEKKMRTLA
                     RHTYYCVYNRKKIGILGGK"
     gene            complement(28446..28745)
                     /locus_tag="JWH23_RS09300"
     CDS             complement(28446..28745)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09300"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_277408886.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 1.7e-07, bitscore:
                     28.3, seeds: 73, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNNLGEYINPWIRFFERKYVESIRLGQEIEITDSDMGMLLTEDID
                     MNQLPKSMEIYFNYVKDNGRDVYYLSNIFGSTYAGKSFGRFSHLMKNPEQFFKK"
     gene            complement(28738..29895)
                     /locus_tag="JWH23_RS09305"
     CDS             complement(28738..29895)
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: protein motif:HMM:NF016615.4"
                     /locus_tag="JWH23_RS09305"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_277408887.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 4.6e-66, bitscore:
                     221.8, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 2.8e-09,
                     bitscore: 36.1, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKDLFKDIGSFMIRTPGLPINLLTDNIENANNIDQTMFLFDSPQY
                     KDQFNEAIFVASQDLYESMQHYIEDGTARDTNYLLNSIYKYFSRSCSRCTPFGLFSTVA
                     FGNITSDRTSFELSSPELKRNPLIDSEWLYQVVFMYESKYLKSLRYTINESVAIQRNKA
                     ILFNCTKDSDGGKVNKKSVKYSNAFEVVLRISGDYVSYTDIIENLKKEYPNVEENTFHT
                     YIQSLIKEGYLISDLRPPLTIVDQFEYFICKLQEYNINTNSLVDIKNEIQEYSNGYINN
                     TIECLTQIFKDMKRIYNSKNYLTIDSSFSYSECNLNQNEIKKINKLLNLFIQFNIKEPF
                     NSLNDYKNKFLEKYGLSRCVPLTELIDPDTGIGFPAHYDGKNRHE"
     aSDomain        complement(29176..29373)
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JWH23_RS09305_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.20E-11"
                     /identifier="RREFam001.1"
                     /label="JWH23_RS09305"
                     /locus_tag="JWH23_RS09305"
                     /protein_end="240"
                     /protein_start="174"
                     /score="36.1"
                     /tool="antismash"
                     /translation="GKVNKKSVKYSNAFEVVLRISGDYVSYTDIIENLKKEYPNVEENT
                     FHTYIQSLIKEGYLISDLRPP"
     gene            complement(30055..30228)
                     /locus_tag="JWH23_RS09310"
     CDS             complement(30055..30228)
                     /GO_component="GO:0005576 - extracellular region [Evidence
                     IEA]"
                     /GO_process="GO:0042742 - defense response to bacterium
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR03731.1"
                     /locus_tag="JWH23_RS09310"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="gallidermin/nisin family lantibiotic"
                     /protein_id="WP_277408888.1"
                     /sec_met_domain="TIGR03731 (E-value: 2.5e-12, bitscore:
                     45.1, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKDFDLDLKMDKGSVDVGESKIASVAYCTPGCLTGTTCGTSECG
                     MTRNCTNTWLCY"
     CDS_motif       complement(30163..30228)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MNKDFDLDLKMDKGSVDVGESK"
                     /locus_tag="JWH23_RS09310_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(30055..30162)
                     /prepeptide="core"
                     /locus_tag="JWH23_RS09310_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-2.00"
                     /molecular_weight="3503.0"
                     /monoisotopic_mass="3500.5"
                     /core_sequence="IASVAYCTPGCLTGTTCGTSECGMTRNCTNTWLCY"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MNKDFDLDLKMDKGSVDVGESK"
                     /leader_location="[30162:30228](-)"
                     /alternative_weights="3521.0"
                     /alternative_weights="3539.0"
                     /alternative_weights="3557.1"
                     /alternative_weights="3575.1"
     gene            complement(30893..31015)
                     /locus_tag="JWH23_RS09315"
     CDS             complement(30893..31015)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="hypothetical protein"
                     /protein_id="WP_277408889.1"
                     /transl_table=11
                     /translation="MNAYEEGLGVLDTLFARDYQFALATSNNNIPAVRFIDTFL"
     gene            complement(31028..31378)
                     /locus_tag="JWH23_RS09320"
     CDS             complement(31028..31378)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_005816008.1"
                     /locus_tag="JWH23_RS09320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="DUF2200 domain-containing protein"
                     /protein_id="WP_277408890.1"
                     /transl_table=11
                     /translation="METPRIFHMPFSSIYPLYIKKAEKKGRTRKEVDEIIFWLTGYDTN
                     SLQQQIEKEVSVEDFFRQAPHINPNASLIKGVICGYRVEEIEDELMRQIRYLDKLIDEL
                     AKGRVMEKILRK"
     gene            complement(31378..31812)
                     /locus_tag="JWH23_RS09325"
     CDS             complement(31378..31812)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JWH23_RS09325"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /product="general stress protein"
                     /protein_id="WP_277408891.1"
                     /transl_table=11
                     /translation="MNEEIIARAGEIIATNTAGEEKGYCALTLMDTDNFPTTSTISVSK
                     ADGINWLTFCTGLGSNRTKRIDLSNKASICFNSIDHNITLVGTIEVITDPEMRDVVPWT
                     GESFQWMGGSQLLRFTFHHKPIQSSHRLERSQRVYIKEII"
     gene            complement(32061..33587)
                     /locus_tag="JWH23_RS31315"
     CDS             complement(32061..33587)
                     /GO_function="GO:0016772 - transferase activity,
                     transferring phosphorus-containing groups [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF014895.4"
                     /locus_tag="JWH23_RS31315"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="putative PEP-binding protein"
                     /protein_id="WP_349772993.1"
                     /transl_table=11
                     /translation="MIDPRNLDTLLHPQFDAEVLKKTEPVGKALAASPGAACGKIVFTA
                     DDAKAWKERGEKVVLVRLETSPEDIEGMKAAQGILTVRGGMTSHAAVVARGMGTCCVSG
                     CSEIAMNEAAKKFVLAGKEYHEGDWISLDGSTGKIYDGIIPTVDATVAGEFGRIMAWAD
                     KYRKLKVRTNADTPADARKARELGAEGIGLCRTEHMFFEGERIDAFREMICSDTVEERE
                     AALEKILPVQQCDFEALYEALEGNPVTIRFLDPPLHEFVPTEEDDIKKLADTQGKTVEQ
                     IKTIIDSLHEFNPMMGHRGCRLAVTYPEIARMQTKAVIRAAINVQKAHADWNVCPEIMI
                     PLICDEKELRFVKKIVVETADAEIAAAGSSLTYQVGTMIEIPRAALTADDIAKDAEFFC
                     FGTNDLTQMTYGFSRDDAGKFLNSYYDTKIFENDPFAKLDQTGVGKLMETAIKLGKGVR
                     PDMHVGICGEHGGDPSSVEFCHKIGLDYVSCSPFRVPIARLAAAQAALNN"
     gene            complement(33589..33879)
                     /locus_tag="JWH23_RS31320"
     CDS             complement(33589..33879)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.4"
                     /locus_tag="JWH23_RS31320"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /protein_id="WP_349772994.1"
                     /sec_met_domain="PPDK_N (E-value: 7.5e-12, bitscore: 43.7,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFLMNAQGEDVVAGVRTPQKIEQLKEVMPEVYHKFVGICSILE
                     DHYKDMQDMEFTIEDKKLYMLQTRNGKRTAKAALKIACDLVDEFMITEESS"
     gene            complement(33872..34682)
                     /locus_tag="JWH23_RS31325"
                     /pseudo=""
     CDS             complement(33872..34682)
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016301 - kinase activity [Evidence IEA]"
                     /GO_process="GO:0016310 - phosphorylation [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PPDK_N"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF013491.4"
                     /locus_tag="JWH23_RS31325"
                     /note="frameshifted; internal stop; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /product="PEP/pyruvate-binding domain-containing protein"
                     /pseudo=""
                     /sec_met_domain="PPDK_N (E-value: 2e-15, bitscore: 55.4,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARKWVYLFTEGSADMKNLLGGKGANLAEMTNLGLPVPQGFTITT
                     EACTQYYEDGETINDEIMGQIMDHIEKMENHRQEIW"
     misc_feature    34892..34907
                     /note="TFBS match to LexA_variant_1, Repressor of DNA
                     damage response, confidence: weak, score: 20.87"
                     /tool="antismash"
     gene            complement(34898..36259)
                     /locus_tag="JWH23_RS09335"
     CDS             complement(34898..36259)
                     /GO_component="GO:0016020 - membrane [Evidence IEA]"
                     /GO_function="GO:0015297 - antiporter activity [Evidence
                     IEA]"
                     /GO_function="GO:0042910 - xenobiotic transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_process="GO:0055085 - transmembrane transport [Evidence
                     IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1086: MATE efflux
                     family protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002602514.1"
                     /locus_tag="JWH23_RS09335"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="MATE family efflux transporter"
                     /protein_id="WP_277408892.1"
                     /transl_table=11
                     /translation="MVNYFKTFKRRLNYEKVNLLEDPVKKLFAGYLLPSISATMVTSIY
                     ILADTLMIGRGVGAIGIAALNILLPLFSLFFATGMLFGAGGGILLSVCKGKKDESGANQ
                     YYTVAFIMAAGISVIYVVLGHAFFLPVTGFLGRNENMTPYVTEYGRILITGAPAFLFAS
                     FYQVFVRNDKAPRLAMTAVVCGGVLNIILDYILMFPLNMGMAGAAAATVIGTCVTLLIL
                     LTHLISKGNTLKFVSGFHLSQAVAVVKNGFSSFLLDMCNGIVTFLFNRQILSVAGELGV
                     VVYGIISNSAYIASSVNNGISQAVQPILATNYGAGKKDRLKEVRHLAERTACLSGVLFA
                     VTGLLFPALVTEAFVRPEKEILAMSVPAIRIYFLSFAAMGLNVLYTTWFQSVMEPGNAL
                     KICLLRGIILNSILVFILPIFMGVTGIWTVMPVTEILTLVACRILLKKQSFCRT"
     gene            36458..37633
                     /locus_tag="JWH23_RS09340"
     CDS             36458..37633
                     /GO_component="GO:0055052 - ATP-binding cassette (ABC)
                     transporter complex, substrate-binding subunit-containing
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_002602513.1"
                     /locus_tag="JWH23_RS09340"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /product="BMP family ABC transporter substrate-binding
                     protein"
                     /protein_id="WP_277408893.1"
                     /transl_table=11
                     /translation="MKKRALALAMAVMMAATLSACGSAGKGTATTAAPSAETTTAAEKT
                     AETTGATSVKSDSSTGYELALVTDLGTIDDKSFNQGAWEGMKKYAEENKISYKYYQPQE
                     GTTDSYLETIGLAIEGGAKLVVCPGFLFEEPVFLAQEQYKDVHFILLDGVPHNADYSEY
                     KTESNVMPILFQEDEPGFLAGYAAVKEGYTKLGFLGGMAVPAVIRYGYGFAEGADYAAK
                     EMGIDGVEIMYNYTGAFAATPEAQSMAASWYQNGTDVIFGCGGAVGNSVMAAAQEKGKK
                     VIGVDVDQSYESETVITSAMKQLSVSVYDGVKDFYDNKFPGGETSIFSAKNNGIGLPME
                     TSKFTKFTKEDYEKIFTELKDGKVTLVQPSQDNNDPNKDLKLEKTKINFVE"
     misc_feature    complement(37711..37726)
                     /note="TFBS match to RutR, Regulator of the pyrimidine and
                     purine metabolism, confidence: medium, score: 21.05"
                     /tool="antismash"
     gene            37820..39357
                     /locus_tag="JWH23_RS09345"
                     /pseudo=""
     CDS             37820..39357
                     /GO_function="GO:0005524 - ATP binding [Evidence IEA]"
                     /GO_function="GO:0016887 - ATP hydrolysis activity
                     [Evidence IEA]"
                     /GO_function="GO:0042626 - ATPase-coupled transmembrane
                     transporter activity [Evidence IEA]"
                     /GO_function="GO:0140359 - ABC-type transporter activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_006780315.1"
                     /locus_tag="JWH23_RS09345"
                     /note="frameshifted; Derived by automated computational
                     analysis using gene prediction method: Protein Homology."
                     /product="ABC transporter ATP-binding protein"
                     /pseudo=""
                     /transl_table=11
                     /translation="MDYIIEMLHITKEFPGIIANDDITLQLKKGEIHALLGENGAGKST
                     LMSVLFGLYQPEKGSIRVRGNEEKITGPLDANALGIGMVHQHFKLVENFTVLQNIVLGM
                     ETTRRGFLKMDDARKKVMELSEKYKLFVDPDALISDITVGMQQRVEILKNAVS"
ORIGIN
        1 ttattatatt ccctgctggg gctgaagtga gtcaggattt tagttccgtc aattccctcc
       61 cagtagaagg tgtcataagg cattttatta aattcattcc agctgatttt ggttgtcata
      121 aaataccgga ttccacattt tttcataatc tggggcagcg cggcagaata tccgaataca
      181 tctggaagcc acaaaatcac attgtctgtt ccaaactctt cccggaagaa ttccttcccg
      241 tgaaggaact gcctgaccag tgattctcca gaagataaat tgcagtccgc ctccacaaac
      301 atgccgccct ctgtttccca tcttccctct gccacgcgtt ttttaatctc ttcatacaca
      361 tcgggagcgt tctttttcac atatttgtaa agctggggct gactggacat gaagacatat
      421 tccggatact gtctcatcag ctccagaacc gttgaaaagc ttctcactgc tttatcctct
      481 gtaacagcta aagtccacag ccacgccaca tcaatgtggg tatgccccac acagcatatg
      541 gttttacttt ctccgccaca gtagcggtca taaaatgctt ccttcatata ggtggaagcc
      601 ttttttaaac tctcatagta ttccggtgaa tactcttttc ttaaatccag cagattcaaa
      661 gattcatttg ctgcggttaa aatggtaatg cagctgctgt caccgtcagg cagcagtttt
      721 gctgcttcat agggaacgga tacatcataa aaatactgtt ccgtctcctg gtcgaggatg
      781 cggattttag aatccatcac cagcttaaag ttctggtctc ccgtaaaagc agacaaaata
      841 atccggaagg tttctcctgc ttttgcctgt ctggttaaaa gcacttcccg atgatttaca
      901 tcaagcccct ggcgcctgat tccatttaca taaatggtaa actgaggatt ggtggcatcc
      961 cagaaacctt cccttcctgt ccgcagttca taaaccacac actggtcttc ccattcctct
     1021 ggtatggtaa cttccgtttc aaaccagtaa tactccctgt gtccacccca aagctcttct
     1081 tttgacagca cctcccatga ctgggtatcc agatcactga catgctcaaa ccgttctgct
     1141 gatttcagca tccggtactc tgataccgga atatcttctt tatagatcaa agactgtaaa
     1201 tcacttaaca gcttaccgat tctctctttt attaatatca cgtgaaattc ctcctttttt
     1261 agcccttggc tgctccagcc atattaaagc cttttgacat gtaattttga gacagaacat
     1321 aaaggacaat ggaaggaact gcataaactg cggaatacgc tgccaactgt ccatagatca
     1381 ccattccatg ctgcccgaaa aactgataaa gtgtgaccga agcgggaaac ttatccagag
     1441 tctgcagcaa aatataaggc acgaagaaat tgccccagct tcctgaaaag gtaaaaataa
     1501 aaaccacaca aatccccgga aacatgagag gtgcaataat ctttcttaag ctgtcaaaag
     1561 cagatgcccc atccacccac gcagcctcct ccagttccac tggcacatta tccataaaat
     1621 ttttcatcag ccagattcca tagggcatag atgttgccgt aagaaataat atgagccctc
     1681 caatcttatc atacaaccca acggtcagaa acattttata aacgggaacc atcactgctg
     1741 taatgggaag tgaggtcata aataaaatcg tatataaaaa acaggttctt ataatgaagt
     1801 tcatatcttg acaggggata tgctgcaaaa cctgcaatca gaaccaccag tacggactgc
     1861 cctaaagaga tgagaagccc atttccaaac gctctctgat ttgcctgatt aagcagtatg
     1921 gttttataat tctccatggt ccactgagac ggcatcttca ccgcctggga tgcattggca
     1981 tcaaaggagg caagtaaaat ccagagaaga ggcagggcaa atattacagc taaaattgtg
     2041 agtaccaggt aagggattgt ttttcgaaat ttccaataca tgtggttgcc tccttaatca
     2101 tttctcataa ttctggtata aaatacgctc agaacaattc caatcaccag gaggatcatg
     2161 gatatggcag ttccatatcc cagctgctgg gaaataaatg cctgtctgta cataaagatg
     2221 ggaagagtca gggttttttg ttcccggacc gccgcctgtc atcatataga tcaatccgaa
     2281 cactccaaga gtggacagag tatttagcat ggtattggtt gcaatggtat ttttaatgca
     2341 tgggaggaca atccggatca tggtctgaaa aggccctgct ccatccactc ttgccgcttc
     2401 ctcaatatct gcagggactc catccagagc tgactggaag ttcatcatgg aaaatgctgt
     2461 tccgtgccag atatttgcca gtattaccgt aagcatggga attgcaaata aaaattccac
     2521 ttgcggcaga tggaaaaaag aaaagatctg gtttaaggtt ccgctgtctc caaaaaaagt
     2581 gctgcagcaa agagcaacga ccacctcagg catgatccag cctgccaaaa agatgggacc
     2641 tacaatccct ctgaaaattc tgttcttatt tctcatatta agagcgatga taaagcctaa
     2701 aacctgctgc ccaatcagac taccaagcag aaataccagg gtgttaccaa tgctgatgcg
     2761 gacagttctg tctttaaaca tggtaaaata attactcagt ccgataaatt ttaactgcct
     2821 ggcattctcc cctgacaaag ccaggtttgt aaaggagtaa tataccgtaa gcagaatggg
     2881 agtgacaaag aaaactagca gaagcaggac tgacggcatt aacagtaccg attttctcgc
     2941 ctcttccagc aggctgcttt gttttttatt catagttgcc tccttatgga atgcgggtaa
     3001 agggaagggc aggtactgaa ctaacctgcc ctctctgacc tcattctgat ttacttttcc
     3061 actacatttt cctcgcctac gctgttggtc acatctgact tatactgtgc cattgcatcc
     3121 tccgggctgg taccggacac gacggattcc accatcgtct gaatgtgggt ggtaacagtg
     3181 gtatactggc tgtttctcgg acgatagaac gcgcctgaga ggaagccggt gcaggtttcc
     3241 ataaacggct gggaagaata ggaagcatct tttgcaatgt cggttcttgt ggcaatattt
     3301 ccctgagcaa taatggtatc taagtagaca tcatagctca tgcagtgttt gataaaatcc
     3361 atggctgcat ctttttgatc ggacagattt ggaatggata atgcccagcc acctgacatg
     3421 gtaacgttgc ccggcgcctg tccttcactg gttggcatcg ctgcaattcc aagcttatcc
     3481 ttatactccg gccacggtgc agcccctgtc tccttatagt ttcctgtcat ccagtaacca
     3541 tctaaagtga tggccagttt gccttttggt aaatactctc tggaagcgat gttacctgcc
     3601 tcaccattta atacttttga taaggaagga ccgtaaccat ctttataaat tgtgctgaca
     3661 aaatttaatg attttaaaat attatcactt ttaacaatcc atttgttgtt atcaagaagc
     3721 tgctctcctg ttccgtaaag aagcatctca taggtctgca tggaagtggc ttcgccggtt
     3781 gctacaccgg agttgcacca gaatggaact acatccggac atttttcttt gataaccttg
     3841 caggtatcaa ggacatcctg ccaggttttg ggctgccagt tggtatcaag tcctgctgcc
     3901 gcaaatacat ccttgttgta ccaaagccct ctggtatctg tactataagg aattccatat
     3961 acgcttccgt catcgtaggt aacgccatct accagtgcac cgtagaaggt tccgtcattc
     4021 cattccttat aatcctttaa ataactggaa agattggtta aatatccggc agccacgtct
     4081 gagggcagct ggaaagtatc ttcacatacg atatccggcg ccgtatcagc agactgaaga
     4141 gccagagcca cctttgcaaa ataatctccc tctgatgcag tgatcggtgc gatatccagt
     4201 tcaatagagt ctttcttgtc ataggtttca taggcgtgtt caaaccattt tttcagcaca
     4261 tcgcttccat catttcgaaa ggtaatgctg atctttgtct ttcctgctgc cgctgttgtc
     4321 tgaccagctg gtttttccgt ctccttttgt gtggctgccg ctgtacttcc tccctgtgtt
     4381 tctgacttgc ctcctgcccc ctgacaagcc gttaaggaaa gcgccataac tgaagcaagc
     4441 gctgctgcct gaatccgttt catttttttc ataataccct ctcctttata tttgttagat
     4501 gaatcatagc ataagacatt tccccggtgt attccaaatt tttagaaaag gggtgtaatt
     4561 ttaacctccg ccttaccgtt ccagaatggc gctgcgaatc tctccctgaa gccttgcccc
     4621 aactgcctgt ggcgtcatgg atttgtctcc gaaaaagtcc gacattgctc ctgcaatgga
     4681 atcggaaata ataaaccatg tggaataggt gctttttaaa acactctggt ttcgctcccg
     4741 ttccacaaac gcatcagaaa gtccccgcac tttccccgga ttgacacata catcagttct
     4801 gacagaaagg ctataggtat ttttataata agattcagca acctcgggag aagttatgta
     4861 atccagcaat tttaatgctt ctgtctcatc tgcagtctca gtaaccccga tcatatcccc
     4921 ctgaaataaa aaagtctgct tttgaatata aggaatttcc gctatctcat aattaatctg
     4981 gctgtcggaa tgctctaaca gtgacatgga gcttagcttg gcaactgcaa tctttacata
     5041 tccactggaa aaagcctgca taagatcctt ctgattccag ttaatcacat cctgggcaat
     5101 gattccttca tccctcattt tcccaagtat ctcgtacaat ttcaggctgt tatccgaatc
     5161 cagacctcga agattccccc ctgccgaata gaccagctga agaaagctgg aagcaatatc
     5221 ctccttattt tttactgcaa tcccaaagct gtaggtcccc agacttttgg tctctctgca
     5281 aagattataa aaatcatcca tattatcggg gatctctttt ttgtacctgg ctaaatgatc
     5341 tttgttataa aacaccacat atggattgct ggtaaaggga acgccatagc agattccatt
     5401 taccacacag ctgccataag catgctttaa aaaccggctg gttctctccc ccgtcatata
     5461 atcagacaga tccttaagaa tatccataga ctggagtgca ggcgtcatca cgctgtcaca
     5521 gataattaag tcaggaagac tattctgatc cttatataga cagagctgct tttgaaatgc
     5581 agactgagcc acatactcag taaccacctt gggattacct ggtatagcag aatattcatc
     5641 cagtattttc tttaagtatt catcactttc atcctcttca taaactgcca taatcaccag
     5701 ctttttttct gcatttccag gacggtgtac cacattggtt tccctgctga aattaaccag
     5761 aactcccatc agcaaaagaa atacaacagt ccaggctaaa atcagtaatt taccaattct
     5821 tcggttcaag gtctataccc cctttctgta atccgacggg cagactcctg caatggaacg
     5881 aaacacctta ttaaaatact tggtatcctt aaatcccaca agctccgcta cctcatagat
     5941 tttatattta ccggaggcaa gcagcttttt agccgtacta atccgaaatt cccctaaaaa
     6001 tgcagtaaag ttaatcccca tttccttggt aaacagcttg cttaagtatt ccggagtaat
     6061 tccaaccagt tccgccgcat cagtcaggga tatttctctg gcatagttct gccttataaa
     6121 tccaatgaca ttcaaaatca tcccgttgtc tgtcagcgcc ccgctgtccc tttcatctgt
     6181 caccatacca ataatcttcc agtaattatt taaaaatacc tctctgattc cggttttcat
     6241 catatcgttt aagagatact ggtacagccc gtctatatct ttttccttca tcagttctct
     6301 tgctgtgtca agaattgcca tgacaaaacg tactgtatgg ttttttattg tttcaggccg
     6361 ctctctgcgt aatattacct gttcctcaaa aagccctgcc attcgtctga taccgtcctg
     6421 atttccaatc tttatttccc gctttactcc atgctccaga tattccggat aatcaatccg
     6481 ctcaaaagcc agctttttta taagctcctg atccataata cagctttctg agaacaaaaa
     6541 actgtaagat aagctgtcct gcatctgccg gataacatcc tttaattctc caatcccata
     6601 gatactttca aaactaatta gaaattctcc cttctccttc agttctttta aaattctggt
     6661 ctggaacaga ttttttaaat atcgtacact ttgtccgtcc aatatcatca ccagtatctg
     6721 cctttcataa ggcagcagaa aggtataaaa gctggtcagg cagtttgttt ccagactatc
     6781 ctttaacagt tcagccatct gttttgtggt atcctccaga atgctttccg actgtattaa
     6841 aaacagagaa atctcctgac cgttctggta gcggatttca ctcacaaact gcctcatggc
     6901 ttcctctttt gactctcctg tcagcaggga aaacagcagc tgctggggtg ataccgtctt
     6961 tgccctggtc tttgacagcc tgttttccac agtctctaac acactcataa tatcctctac
     7021 gcttaaaggc tttaaaagat attccacaac agacagctga attgccttct gagcatattc
     7081 aaattccgaa taaccggtga gtacaactgc tgcagcctca cacccctctt ttctcatacg
     7141 ctcaatcatg accagtccat tcatctgagg catgttaata tctgtgatga ccacatcagg
     7201 ctgtaaccgc aaagcctcaa gaagtcccgt ttcgccatca cttgccccct ccaacaacct
     7261 gatgcccggt ataggcctcg ataattttaa taattccgtt tcttgtattg ggttcatctt
     7321 ctacaacgag aattctcata cctgtcctgc ctcctgactg ctattcaaat aaaatttctg
     7381 ccctgactgt tgtcccgttt tcgtctgata caatttcaaa atgaccctca tcgccatagt
     7441 aatacttgat tctcatgatc acattcctca caccgatgct tccctctaaa gaactggcag
     7501 aataatcgta atgattgagt tcatgaatta attcagaatc cattcctttt ccattgtctt
     7561 tcacctcaaa tatcagatgc ctctcccctt tttttctgat ggttatggtg attaaatcct
     7621 ctcctgactt accagggaaa ccatgattga tggaattttc aatgagaggc tgaaataaaa
     7681 gcttatgcat cttaagatcc atcacttcct cttcaatatc cataatgcag tggaaggaaa
     7741 atgaaaaacg ctgctgttgg agaaatatgt attgcttcaa atactcagtc tcgcttctta
     7801 cagtgaccac gccattgctt ttatgaatac tgtaacgcag aatattggcc aggtttttta
     7861 acatcttact gattaaaaac tgttcatttt ctattgcaat ccagttaatg gcatccaggg
     7921 tattataaag aaagtgggga ttgatctgtg cttccagtgc ctttagctcc gcattcttct
     7981 ctcttaaaag agcttctttc catcctgcct gactggtcta tctttgtgac catgtgatta
     8041 aaatgccttg caatggtacc gaattcatcc tgccaggaat ggctgatctg gaccgtataa
     8101 tcccctttat aagccctatc catggctgat gtgatcttct ccaccctgac ctgaagagac
     8161 tcggcaaacc ggagcatgat cagaatgctt gtgattataa tcaggattgt caataagata
     8221 attacttcaa aaatatattt aaaatctttt aaaagctctc tgttatcccg tatggtaacc
     8281 agcacatact gaccatttaa aaccggtttt gtgtagatgc tggaaaagct ggccttagtc
     8341 gccggctcaa ttcttgttcc tatgagctcc gcccggttac tggagataat gattccattg
     8401 gtatcacaaa gaaaggaaac ggttctgtcc tgcttgtctt cctgagaata cgtctccctg
     8461 atccgttctt catccaggca gattaaaata cttcctaccg ttccctgtct gtaattgtta
     8521 atatccgcaa ttctgtgccc caggtaaata atattcctgc tggttccgtt atcttccttc
     8581 cggttaatca tgtcagaata aaccgtcctg gtatttaaaa acgtctcatc tgccacttcc
     8641 agccagcttt tatccctgtc tggaaaacag aagctgttca tgatgctgtt agtaacagag
     8701 tcatacccga tacactcttt tttctgggtt accaccgcaa tccccagaat ctccggatgt
     8761 aagtaagata tattttccag atcatcttcc agttccttct ttatgagata ataatttctg
     8821 gaatcccaga catttaattt ttcaagcttc agtgcatact gattttctgt atagatcgac
     8881 atgataatgc tgtcatactg ggaaaaataa tcctcaagac ccttctgtga cagcttcata
     8941 ttgctttcca ttaaaatgtc tgtctgacgt tttaaggtgc tggcggcaat catgcaggtg
     9001 attgtctcca ttatcattaa cggtacgatg gagcctgcca gcaaaataat aagagttgct
     9061 atgctatagc ttttatatct gttaagtagt tttctgatca aggccggctc cttttattgt
     9121 gtaattacga taatttaaca ggattttatt ttgctattat agcacatatt accaataaca
     9181 ggcaatccac acatacatga attgtttcac aaaaaaaggc agcccactaa ggctgcctta
     9241 aataatattg tattctcttt ttttaccccc ccagggtcac atcctgcctg gagtaccact
     9301 ccagcgcttt gtaaacatga tctgttttaa aatccggcca gtaatcgtct accacatata
     9361 gatccgaata aacggactga accgggagaa agccggaaag tcttctcctt cctccccaac
     9421 ggatgattaa atccattctg gatacatcag aggttttaag ctcaggacct atggttccgt
     9481 ctgacagtcc caaatcccat tcccagctgt aattgatgag aaaattgatt ttcattcctc
     9541 ctgtaccaaa gcacaccctt ttggtatatg gtttaagctc gtccggaaac atagccgaag
     9601 aagttttccc aagaaccaga agctgggcat tctctttaga caacacctcc acagccctta
     9661 cgcaggcctt ggaaaatgct tctctttgta cagacggacg tttggtatta tctgcggtaa
     9721 agccataaaa ggtcatctct tctactccca gatccttgca aagatggtaa agggtcattc
     9781 caggtgagat acctttatca tacccttctt ctttttttat gccattctcc acagcccaac
     9841 gtctgtttcc atcaggaatg ataccgatgt gttttggaat tctcattatc tgccctccat
     9901 gattggttcc cttcgaggaa gtcctgttaa aattatagcc aactttttca aaggatatca
     9961 tgtcctgcag aaaattatgt aattatagtt gccctggtgc ttatttctta aatttcttaa
    10021 gatccggcat ctttggctgg tgatagatat acatgcatct gctttcagat gccagctcca
    10081 cagattttct agctacctgt tccatgaatt tagctgcgat attactttta cctttcattc
    10141 tttctacctc cattattata aagacattaa gataatgcaa ttatacataa acaacagcta
    10201 tataaagaca agttgtaaaa attacggctc tgctcgtaac tattcccgat tttggtactc
    10261 atgaatcctc ccattgtcat ttttataaaa aaacatgaac agcaccagaa cgagacacag
    10321 caaaatgtta ataagattta gcagggatat aaaactttct cccaaaaatg cggctctcct
    10381 ttcaaactgc atttcactcc actcaataca attggaaatg acaacagctg tcatcatatt
    10441 tattacataa atttttctgt ttgtttttcg attattattt ttttcctgaa tgagatgtac
    10501 taaatttaca actaagaaca cggtgcagag aaaaatgatg aaaagcagat agtgtttcaa
    10561 ttttgttacc tccaatatta aaatgtgata taattttagt gcaataagaa aatattatat
    10621 ttccattgaa aaaatcacac catgttgaaa tttcgagcct gcaagtaatt tttaatttaa
    10681 tcaattagac aaaatacgac aaaagctcct aattctctct tttaattaat gggaagtatc
    10741 gtacgatata caattataga tgtttcattt ttgcataaat aaagtaaata gttttaatgg
    10801 ggaagggtac gtatgttaag aatagcaatt tgtgatgacg acgttctgtt tacaggaatg
    10861 ttagagaatt taatcaaaga agaagctttg acaaacggta ttgaaattga agttgacgta
    10921 ttttttgatg gatccatgct gacaaaatat gtacatcttg gtaacttatt tgacctgatc
    10981 tttcttgata tagaaatgtc acagcaaaac ggaatcgagg ctgcacgccg catcagagag
    11041 attgataaga ctgcattgtt aatttatatt tccggatacg atcagtattt aaaagaattg
    11101 tttgaggtgg aaccgtttcg ttttctatcc aaaccacttg ataccgcaaa gttctcccgg
    11161 tatttcaaag aagcatatga acggatcaat gaaaataatg tctatttcca atttaatttt
    11221 aataaagaaa ttaaaaaagt agccttaaag gatgtagtct actttgaaag ccgcaatcgg
    11281 gttgtataca tatatttaaa ggatggcaga gaagaatttt tttatggaaa gcttaacgat
    11341 gtggaaaatg agttggccgg aaacaagcag cgttacctgc ggatacacca atcctatctt
    11401 gttaattatg attatgtcag caccatgaat ttttccagtc ttgtaattga gaacggagga
    11461 aagtcaacca cacttcaaat cagcgaagac aggcagaaga aaatccggaa gcagttatgt
    11521 gatctggcca gtaagaaagc gggagggaaa taatatgaaa attctttcaa caaccgttgt
    11581 cagtcctttt ctttcacttt tttatatttt agtcatacgg aaatgcatca acgctttttt
    11641 cgctccctcg tggaagaaaa ctacaaccta tataatctgg atcgcatatt atctttttca
    11701 gttatttctg ggcattggaa gtggaattcc cccgacactg acccttttcc ttaacatggt
    11761 ctttgtcttt ctcgcaacca gtatttctta ttcagaaagc tataaaaaat gtgctttatt
    11821 ctctttttta atctgtgcaa tctggatgct tgtggaaatt atcatacata tgatcttaaa
    11881 tatgatgaat ttagatgata aagccggtct ctcaggagcc attatctcta aaatagtaat
    11941 gatggttttt gccattgtca ccggacactg tcttcagcat aaaagtatag gagatatttc
    12001 cttacggtat atggcgattt tacttatggt tcctgccgga agtatttaca ttatgcataa
    12061 tatttttctc atcagcagca cggctgagga tgaagttctt ttctccttta tatctggtat
    12121 tttactgctg tttattaact atattatttt tgaagtattt gagtctctgg cagcaagttc
    12181 agagtatcag aaaaaaactc tcctctatga acagcaatta gagctttgca gccgccaggc
    12241 tgaggaacgt gagatccaaa acacggaaat acgtttattg cgccatgaca tgaagcagca
    12301 cttagtcagc atactgggca tggttaattc cggaaaaaat gaagaagctg ccacttatct
    12361 cacttctttt ttagaaaagg gaacctcaaa aaaaattaat gaaatatccc acagcggcaa
    12421 tattgtagtg gactcacttg tgaattataa atcttccatt gcccgaaaac aaaatataga
    12481 attctgtacc aatattttta ttccgccggt aatgcctttt caaaacggaa atctgaccat
    12541 tatactgggt aatctgctgg aaaatgccct ggaagcctgc cgccagatga atagcggaca
    12601 tccaaaaatc gatctggaaa tgtcttatca gaaggggatt ctttccattg ttgtctggaa
    12661 tacttttgaa ggggatcgat acacagacgg gcagaaacat tttcttacca ctaagaaaaa
    12721 ccccgcccat catggcctgg gtctgttctc cattgaacag gcggtagctg cctgtaacgg
    12781 ggaagccatc acacaggttg agggaaacat atttaaagcg gttgtgatct tatatcagga
    12841 accggaaaaa taacaaatta ctgatcaggg ggtggggaat atggagcggt tatccattgt
    12901 attaaccaat tatattctaa aaaaagaagt gatctctaag gaagattatg aagtttatct
    12961 atatggcttt caaagctttc tggaactgtt tttaaatctg gtctgcagtc tctgtattgc
    13021 attttttatt catatggaag tggaatgcct gctcttcttt ttattgttta ttccccttcg
    13081 ttcctttaac ggaggactgc atttgaagtc ttatttctca tgtctggttt tctcctgcgc
    13141 caccatgact gtaatacttt tgattgtgaa gtattacagt ctgaacgccc cggtttcgtt
    13201 tctgctgtac ctggttttta tggtactcat caaactgact ggagcagttg accatcccaa
    13261 ccggccggtt gacacagacg aaaaccagac attgactcat aaaactgacc gtactttatt
    13321 tatcagtttc cttgccgcat tgtgctttct ctttttgaat ttagaaaatt atattttttt
    13381 agaggcgctg atttatctgt tagtatttat cacactgata ttatccaaaa tcaacggcaa
    13441 aaataggcag caagtggaat gagagtttta gtctttatct atctttccac gcaattccgt
    13501 cagaactttt tgtaaaaatt caggcattct ggcgcccatt cgtcctgcat tttctaaaat
    13561 ggagattagc tcattaatga tgagccagac agataccaat aatccaaaaa ttgttttatg
    13621 ctcaaattta attccaatct cagtagaaaa tttatagatc acataatccg tgctgactgc
    13681 cgccagaatg atgaatatat aactggactt tttataaatt ccgatccggc ttttcctgct
    13741 gttccaacca tactgattat tatcagggtt gtccagtgct tccttttttg aagcaagcat
    13801 ccccgatatg tagtccgtga tcataagtat ggttaataac gatatagcag gaaataaaag
    13861 tccgaattga tccataatcc atgcactgat gattcccatt gcgctttttt ccaaatccaa
    13921 ttttttttcc atggctgcac ctcctgtaaa gtccttcact tatttataat agttttcttt
    13981 taaaagattg taaaaatttc ttctgacccg attcacgtat tgtcgggaca cggagtggcg
    14041 ttctgcaatt actgcatctg actcctcatg aaagacaata tcccacagaa taaccgcctg
    14101 ttttccttct gtcttcaaga gcatagtttt tagatcttca tgaaacagcc agtcatcata
    14161 aacaggctga tccatgctga tctcagtaaa aaactcatcc tcaacagaag cttccgcatc
    14221 aaaatgctgc ttgctttttt tatactgttc taagaacttg ttttttaggg ctctgcttaa
    14281 aaaataaaca cattgcccat cttccttata atattgcatt gaattgatgg cctccagcag
    14341 actgagcaca aattctgaat gcatgtcctc tttttcatct ttatataaca ggcggacata
    14401 tttattaatc agtggagtca ttttatctat tatcagtaag aatttttctt tattaccttt
    14461 ttttatttcc tcaataatta catgaacgct ttctcccatt ttcttacctc ctaaaaggca
    14521 aaaagaaaaa aagggtaata ttgtaaacta aattcttctg aatctttatt tttttcgcat
    14581 aacatgattg tagataaaaa actcgctatt tattggaaca cgtaaaaaac gctgaataat
    14641 agggagaaat ctccttatta ttcagcgttt ttctatataa accttattta tttagaatgt
    14701 tttctaccaa accagcattg cccagtctgg tattaattct cctctttctt tgtttttctt
    14761 tatgagaggc tttctactat cctctctcaa ttccgttata tgaaatacat cattgaactc
    14821 tttaaacccg gattctgctc cacctaaaac cgactgatcc ggactggaat catcatatgt
    14881 accagtaaga tatgagcctt cccataagta aatccaacat atccgcatcc atccgatcca
    14941 ttgctcacca gaatcaggca attgttttga atatataatt catgaatcat ataccagccc
    15001 tccggttcgt acaaatcggc gaccttctct aatccatggt ttaagtaagt atatacactt
    15061 atagaaatcc cgtctccaag aattaattca ggtatcccat cttcattaaa atcgtgaatt
    15121 cccaggtaaa aagatgaatt taaaccatct tcccctctta atttatatgg atccggcaga
    15181 tgacctcccc cctggtcgat aatctcccta tatgcagttt gccagttaat ttcctcttct
    15241 gccaaagcaa ctggttcctg taccatattg ctgacctgat tttcatctgg ctgcagaaca
    15301 gttccccccg tcatgttgga atcagcgcag ccggttaaag ataaaatcag aaaacaaaat
    15361 aagaataaat ttttattcat ttgtctttcc cctttaaatt ttgaaacaaa attgtttttg
    15421 ctatttctgg gcataatcat tttattttac tattattact gattatggat ttttcctcgt
    15481 aataattacg ggtctgcacg ttgaaaaagc catagttatt ccactatggc tcatcaaaag
    15541 gtcatcaaaa ggtgtcatta aaaactgtat acgattaaac cggtaaatat gtaatcacca
    15601 tacctcctat gatcaggctc gcaatattgg ccgttattac atataacgct acacgtcctt
    15661 tcctgaattc tttcactaag ttaagaaaag cgatcagttc tgctgcaagc accacaatct
    15721 caacaaatag ataaccatat atccagtaat tacctaaatc aggtcccgta agcattgcat
    15781 tcagccctgc ctgggtaatc agattgactg ctgtaaagac cagccagctt cttttttgcc
    15841 tgaatccaaa aagcagaaaa ataattccct caataagcat cgttaagaga acccgcattg
    15901 ccaccagagc aggaacccgt aacggagcct gacccattgt aagggtctcc gattccatat
    15961 caagggttaa aatattacta tatgttctaa atgtttcttc aggcaaagca cattgaaagc
    16021 ttttattatt actttgtacc accagcactg catcctttaa atccttaacc tgggatgatg
    16081 aatggttgta ataaagcctg taatactttt cccatccttt tctttcccct tccaccactc
    16141 ttaagtatgt aacatcatga tcggacattt ttaaggataa agacatcttc tctggagagt
    16201 ttaatacgat tatggtaaaa cccggcggtt ccgctgagtt ggcgaacgct gttgaataat
    16261 agcagaaaca taagaggtga acaataaaaa tgaagatgca gatactgctt ccatgcctga
    16321 tactcctctc tcttgtcaaa aaaccagccc cacctttata cacattcatt tctctttccc
    16381 ccttctattt tgttgtaatt ataacataca aagccggtat tattgttctt cttccttata
    16441 aaatccttaa aattagctgt taacatagca atatcaagtc aaaaggaggt tccttatgga
    16501 gcgaaaacgg tacaaaacgg ctgctgattt tgaaaaggag gatgttatga tgcacgagta
    16561 tatgttaaaa accaaccaca tttcaaaaaa attcaaaaaa acatatgcaa ttaatgattt
    16621 gtctatgtct gtaagaaaaa attctgtcta tggattatta ggacctaatg gtgctggtaa
    16681 atcaacattg ttaaagatga ttacaggaat catcaccccc acttccggag aaataatatt
    16741 cgataatcac ccctggagca gaaaagatct gttaaggatt ggttccctca ttgaatcacc
    16801 tcctttgtat gaaaatttaa cagcttttga aaatttaaaa gtccgggcaa ctcttttggg
    16861 gatcccaact gataaatgca tggaagtttt ggaaagaatg gacttaatgg atacggagaa
    16921 taagcagatc gctaattttt cattgggaat gaagcaaagg ctggggattg cattagcgct
    16981 tttaaatgac cctgaattat tagtcttaga tgagcctacc aatgggctgg atccgttcgg
    17041 aatggaagat ttaaggaaaa tgatccggac atttgcagta tccgggatat cagtcattgt
    17101 atcaagtcat atcttaagcg agatacagca ggttgccgat gacataggca tcctaaataa
    17161 tgggtcactt ctgtttcagg ataaaattga tgccaatgag aatctggaac aattgtttat
    17221 ggatattata agaaaggagc gtgcttcctg atgttacaaa cctatctggc agctgaaaac
    17281 ttaaaattta aacgaaccct gtttcggaaa ctcattttat atattccggc agccttaata
    17341 ttaatagcag ttatattttt atctgtgggg attggtttag gtggtttttc agcctccatt
    17401 gtctgtaatt ggtgtgtccc cattgcatct ttatccattg tgatattatg ccacttagta
    17461 aataataagg aacaaaaaca caattacagg actatttaca gcctgcctat agacttgaaa
    17521 aatacattta tttctaaaac aattttaata gcacttaatc ttttgctgat atcattatta
    17581 ctttcatgta tatctattat ttcagagtac atgatgtcag gtgtcttaag tgcatttaaa
    17641 cataccggat attatgtttt aggatactgc ttattatggc tgactttatt atggcagatc
    17701 cctttctgcc tgtttttgga tcaaaaggcc ggattcgttg gatctatgat cattaacctg
    17761 attttcactg gacttggtgg tttgtttctt tctctttcgc ctatattctg gtttattcca
    17821 tatagctgga ccgccagatt tatgattacc ttattcggag ttttgccaaa cggattatta
    17881 gttcagggag gtacaagaca gattctgagt ttaggtcaga gttcactgct ggtggtagta
    17941 agcatgctca ctgcagtcgt tcttacattt ttatttgcac actggtacag agggcaggtg
    18001 tatcgaaatt gacaattgca agagagtttc tctctaactt tacaaaaatc aaacgaaccc
    18061 cgcttttact attacatctg ctgcctcctg tggtaatcac aaccttattt ttagtttatt
    18121 acaattctgg tggataccgc cttttttctg atgttcggct gtttttcatt ttgttgcaaa
    18181 tatgctatcc tatgtttgtt agctttgttg taccaatttt tattaattta gaccgaaata
    18241 tcagcaacgt tcaaaatgct ctgggtattg tgggatccag aagaagcgtt tatcttggta
    18301 aattattctt tctgctgttc ctgtctgcca taagtatcat actatacgag ctatgcttct
    18361 atattggagt gaattttttt ctaactatga acgttatgga cgttggatcc tatcttttca
    18421 tattctgctc gttttattaa gtaacttgtt tttatatttt atacatgtac ccattgcatt
    18481 taaatttggt ttcagtgtct ctattttatc ggggatagca ggaacaattt tagccggtta
    18541 ctatgaaaat tacattggtg ataaaatctg gccggctatt ccctgggaat ggggtgtacg
    18601 gtttttaaaa gatttttttg acctggccta tggatcggtt attcctggag tgatttcact
    18661 gattattatt acttcggttg ttctggttct cacaatatta tggtatagta gatgggaagg
    18721 cagagttata caagagtaag attaggagga tagtctatgc caaaactgtt agtcatcgac
    18781 gatgacctgg atatgctggc tctggtacgc accgctctgg aaaaagatgg ttaccaggtg
    18841 gatactgaag caaatgccgc ttccttacag cctgccagat gccggttata cgatcttctg
    18901 cttcttgatg taatgatgcc cggcgaggat ggattttctt tctgcaggcg gatccgtact
    18961 gaagtggatt gccccatcct gtttttaact gccaaggcag aagattcggc tctcgtccag
    19021 ggctttggcc tgggagccga tgattatatt aaaaagcctt tcagtattgc agagctgcgt
    19081 gcccgggtaa gtgcccatct tcggagggaa gtgcgtcagc caacccacat tttaagacga
    19141 ggcatcgttc acttcgatat acaggcaaaa aacagcattt gctggtgaac acacactgcc
    19201 ctttaccaaa ggcgaatatg caatctgtga gcatctggca cttcacgccg gacaggtgtt
    19261 taccaaagaa caattatatg aagccgtatt cggctttgac gcagaaggag atccgtccgc
    19321 tgtcgcagag cacattaaaa atatccgtgc taagctgaaa gcccacggca tcagtcctat
    19381 cgatacaatc tggggggtgg gttacaaatg gcgaaaaaac gaagatctgt aagtctatcc
    19441 tttgtccttt tacgctttgg catcatcatg gttggctgca tgctattatg ctgcctgtta
    19501 tggtatgtgt tgtttatccg gcttgtaaaa atcggttttt tctataactc ttatacttcc
    19561 acccggcaga tagagcaaat gctggctggc gacccggaaa catttgtttc tccaggtgat
    19621 gattttttgg cagagtacgc tttatttgac cagaacggta aagttctgga aagtaatatc
    19681 aaaggaagga aactggaaaa actgaccagt cttttatatg aagacgccta taatatgcgt
    19741 gttgccaaac atacttatgg agatggaagc acaataatca tacgatatta tttcagatca
    19801 gagtttgcaa atcctgttct gcggagtgcc ctgccaccct ttgaatatat gtggctggca
    19861 tctcttgggg cagcattggt gctttgtctg ctatttaaca ccctgtggct acgtaagcgt
    19921 cttgctgcca agctgaagct gtttggcgag gttagccgga aggtaggtga acaggaattg
    19981 gatttcacaa ttccatatgc aggaatacgg gaatacgatc aggcacttga tgcaatggag
    20041 catatgagag atgctttgta caactccctg tcctcccagt gggcggcaca gcaggaacgg
    20101 gaagcagaaa tagccgcgct ggcccatgat ttaaaaactc cactcaccct ggtgggaggt
    20161 aatgctgagc tgctgcttga tgaagaactc cctgaaagca gccgtaggat ggtggaaaca
    20221 atagcaacca gcaatgaacg tgccaggcag tatgttacaa gcttccttga agcctcagca
    20281 ggtgaggagg aggcatttaa aagcaacagc ctgagtgaac tgtttgacca actgatcagt
    20341 aacactacgg ccattgcaga atcaagggga gtatgcatga aagtccagaa tgaccttaac
    20401 ggctttgcaa acattcaaaa agatcatctg cttcgcgccc ttggaaatgt agtacaaaat
    20461 gccatagagc attcaccagt tggtggtaac gtatatttga cagggagtat ggcagatggc
    20521 ggctggcagg tgactgtatg tgatgaagga cctggcttta gtaaggccgc tttacagcac
    20581 gcaacggaac gtctgtggcg tggagatacg gcccgtggtg cagacggtca taatgggctc
    20641 ggtctttggt ttgccgcaca ggtagttaaa acccacgaag gtcagcttta cctgagcaac
    20701 accaagtccg gaggagttgt tacagttaaa ttatgagagg taaactgtac cctgatagta
    20761 agacacagaa aaagaggctg tgtttaacta ttggggtact ttttgttata taatactgta
    20821 aaaagattat ggaggttttt atgggaggta agcgaataac tccagctcat cgtaacaaag
    20881 atttttcaaa agaagaaatt gagatattat cccgaaatcc caacgttaaa agtgttacag
    20941 ctaaacaaat taattatact gatgaattta aaatgcgttt tttagaacag taccagactg
    21001 gaaaaatgcc gttagatatt ttcatagagg ctggtttcga tcaaaaaact tattggtcaa
    21061 gggcgaattg ataaggcggc aggtcgatgg aaaagaaaag ctcatcgtcc gggtggagtt
    21121 tatgatcaaa agaaaggaca ctcggggaaa aagctctcgg gtaacaaaga gttatctttg
    21181 gatgaagaaa tccaatacct caaacagcag aatgcctact tacgccttca gactttctgg
    21241 gatttaaaag atgagattga tgagtatatg gaatattaca ataattatcg ctatcaatgg
    21301 gaactcaagc aaatgtcacc tgatgagtat tatacctatt tattaacagg gtttatgcca
    21361 tactaaaagg cgctgatcac caaaaaagaa tcaacgcctt cttttattat gtccttgaca
    21421 aagggtacag tttacctctt tccatataag taaaatatca gaaaagctat ctgtgtaaga
    21481 gtaaatgttt tggaagtagg aataggttaa tatctaggat aacaatacac ttaataatca
    21541 cataattact ggtaagcgtt tgtaatttta tagttatcta ccactcgata tttattacgg
    21601 tctgggagag gaggtattat actgagttaa ccagactcca tcatcgtcta cccaataata
    21661 ggtattgcca acttcagatt taatgtagca cgatacaaac aggtatgaat ctttaccaaa
    21721 gcagtagtct ttccctgaaa tagttttcca ggttttcgat ggatatgagt agtttttctc
    21781 taaataccac caccgtttat tatcattata gtcttttacc cagccctgaa cataatttcc
    21841 actaatccag ctcttattac ctatgtaaaa ccatggggtc ccatttactg ttatacgact
    21901 tgtagctgta atattacttc ctgtgcttaa cttccttaaa atatcaccat ctacattatc
    21961 agggaaatcc cttatactaa tattagttcc ctgaacagtt aactttgcac ttacaggaat
    22021 ctgtgataca gtatctgtag ttttcatggg tatattaatc ataccatcgg ttgcataaaa
    22081 catatcaagc tctgcgttac gtcgctttac taagcccgat tgtcttgatc cccccagcaa
    22141 ttgtgacagt aaaacctttt actacttcgc ttttaacaaa gatactcttg ttgagtgctt
    22201 tgtataaatc atttttagaa tttgtaatat actctgttcc tgcgttaaat gtcaaagaag
    22261 caacggcatc atactgtgcc tgtgtaaact tagacacttt tggatgttta ttaatgccag
    22321 tttccacagt gagaatatct gcattgaata atgtggttgc tcgactcgct gtgataatgt
    22381 cgccctcttt aagattatct gtagcaacta ccttatggcc atacccaact gtaaggaatc
    22441 caaagccatc atcgtagaca tccaaacgat atttctcaaa actctttata aaatttttac
    22501 cagtagtact aacgttcatt tttattcttc ttatgtatta tttataagcg cttatactat
    22561 ttaaaaagga agaatattca gttttgtaaa ctggtaagga acaaattata aaaaaatatt
    22621 ttatgtactc cacaagacca ctattagtta aggtggttag aatcccgata attaagtgac
    22681 cagattttaa aatcaccatt attatcttta tcaaaccaaa gaattccgtt ttcaacgcat
    22741 accccttggt aatttgtaaa taaatatttt gtatacattg tttcaatctg ctcacgaaaa
    22801 tccgtttctg cgaacaaagt atcaatttga tctgacattt catcctcatt ctgtacagga
    22861 ataacttttt tatttactcg tatatcaagt ggatatcgaa acaattttat gaatttttct
    22921 ttatctgtta tagattcttt tatttgtttg gcgaaatttt caacttctgt tgatgtcatt
    22981 tgacgactca taatacgatc tccgctgtag taatcatcat gatcatatcc tataggcata
    23041 aacgttgaca aatacatact aatcgttaca tcttttccgg aaatattgcc agtacctttt
    23101 aaattgccat cataaacagt accttttaaa tatccgcctt cattatcatt taactcgaat
    23161 tccgttggac ttttcatttc tccacgaagt gttctttcat catcggttcg agtaatatat
    23221 gatgcagtca aagaatcacc ttccctacgg atgttcattt gtacctctga ttctcctatt
    23281 gtacctttaa aaatattgtg tgtattattc cggattggtt cttccatggt ggtttcagta
    23341 tatgtttcct tttctgttgt taacgcctca gtctcagata ctgctgttaa ttgatcagtg
    23401 ctggtttgtt cttgtttagt catttcagtt tttgtacaac ccatgctgat gatacaaacg
    23461 ataaaggaca ccattatcag tgctgactgt ttaacgcttt ttgttctaat cattttcaag
    23521 tgctcctttt tatgaagaat ttttttattc atttgcttcg tatatgaata ataataaagt
    23581 taccagagtg atcatatcca gtttcaatat tgcagatggt gataaaagat tcgcataatt
    23641 aattatatca tggatttcgt cttcggagtc cgttttctat tttaaagtta aaaagtgagg
    23701 ctattgctcc aataaattat tcatctattt ttgcaacagc tcccttttta caattatgaa
    23761 attttctata ataaaaatat ggaatcccat tgtgttttaa cgggttgata gcaagataaa
    23821 atagtcagga tcactccact ggttcctgtt aagagaccta tctcatcctt atttacaata
    23881 tgcccttcct ctatttctgt atctttaaac ccaaacggat attgatcact gtaggattcc
    23941 agtaaatgat ccaatatctt catatacact tcatagaaga agttatcatc tgtgtattca
    24001 tagaattttc tggtcaggca acacaaacca gaaagaccgt gacaaaaagt gggtgagata
    24061 acctgccgca ttctttttaa agataatttc atgctatcga ttgcaagctt actcatttcg
    24121 tcattttcca ggatctttga agcaatcaat aatgaatacg ccacacctgg agtaccataa
    24181 caccatgcat ctctggatgg tactgctttc tcctgttcca tccctaatat tttttgagtt
    24241 tcccaaaaaa tatcatcact gtcttttata cagctgttat aaataaattc tgacaaatac
    24301 tttattgctt ccagctggtc ttgtacatat actcccgatt cataggactt acataatatt
    24361 aaaagtatgc caggtatccc gtgcgcaacc cctaaattta tatatcctat ctctggacta
    24421 ttttccagag gaaacaactg actttcattt gaacggatgg caaaccgggg gatattgtcg
    24481 tcccctgctt tacaaatatc cgttaaatat tgcaaaatgt gcaacagagt ctctttcaca
    24541 ttcggctggg atttaaaatt caacagataa ttggctgtac cggttaatcc atacataata
    24601 tcataaaata gttcgtttaa tggaagttct ttgtacttta gaatattact ttccgcaata
    24661 tcaacaatat actcgtttag actctttata aacgattgat atcgtttccc atggtctgac
    24721 atacaatgtg cagcataccc aactccgcat agcccatcaa acagggagat atcatagatg
    24781 ttgttttttc ccatatagtc gtttacgatc tccagatatt tatgggcata cttatcaaaa
    24841 tcataatctg gaaaatttaa ttgaagttcc gaaaacagga tacataatgc gggatatgaa
    24901 actgctactg aagtacaacg atactcagtg ttatttgtag caaatatctc ctgaacataa
    24961 tctgcgtcgg ataatttttt tgaaatattt attatgaaat gatccaattc acgctttttt
    25021 tcattcggta aattcataat cagcctccat tttggggtat atcaaattcc agatcgtaaa
    25081 tttctttata agagggacat gtttttaata attcctcatg tgtaccttct gccacaatct
    25141 ttccttcgtc cagataaatt attttatcag ctaacatgac atgtgcaatt ttatgagaaa
    25201 taaatacacc tatcttgttt tttgtaagtt caaaaaacgt gttcattatt tttttctcac
    25261 ccattttatc caacgccgca tttggttcat ctaagatata catttgtgct tttttgaaaa
    25321 agcacctggc cagagcaact ctctgccact gcccgccaga taactgtgtt ccatctgaaa
    25381 accattttcc caactgctga tttaaatcag gaggaagaaa gtctataccg gcttcttcca
    25441 gtgactctct tatctgggct tcattatcga tttcatcaat gttgccgaat cctacattat
    25501 cctttaccga aagttcatac ttacagtaat cctggaataa tatacctgtt aatttatgta
    25561 agctgtcaat attaacttta tttaatggga ctccattcat cttaatcata tcgtcttcca
    25621 ctaaataata tcccagtaat aattttatta atgtactctt accagatccg tttctaccga
    25681 acaatgcaac tctttggttt ttattaattt ttatattgat gttctgaaga actattttat
    25741 ctgtttccgg atatgcaaat gtcagattat ttatctcaat ctgatttaaa tcatttagtt
    25801 tgtatgtttc ttcactattc ccatttccag gcttattaag aaaattaatc agttttgaca
    25861 tatacagact gttttgattt atgctgtaaa taatattcat aatactgtta aagctatcaa
    25921 acatcatgtt tataattctt aaaagtgcga cagcgttacc aatcaggatt tcaccagcaa
    25981 ttacggagaa tatgattaaa atcatgagta cagccataca gatctgatca acaaaatcaa
    26041 atacaacaga tataatcagc cgtaccttgg tgttgtataa attttcatta atcacgcttt
    26101 gctttaaatc attatgtctc tttataatat gtctggctaa attaaaaatt ttaacttctt
    26161 taaatgattg atcctttgta agtaaaaatt cgtaatacca tatacttctg gctttcttag
    26221 catttctttc ttctgtctgg aactctcttt tgcttatgga taagtaaaaa atagaaaagg
    26281 caaacgccgg aacaataatc aaaaatactg acaacggccg ccacgtcagc ataatataaa
    26341 cagatgaaag tatggtagta atggaagtta ccagtgtcaa tgtggttgta aaaatattat
    26401 aaggcctgaa tcccacctgg gataggatat gctgcagctg atcctgtatg tcagaatttt
    26461 caaattcctc caaagacata atagcgcatt tatccaataa cctgttaatt aattcataat
    26521 ccaacaagaa ttgaaatttg gtaaataaaa aagttttaaa acttataatc atacctgaca
    26581 caaaacttat cccaatatag attgctaaaa tcttcagcga gagatttaaa tccttggctg
    26641 aaatagcatt aatcaggcta ccaaaaatat ttacggatat tacgggaaca atacccgcga
    26701 taatattaat aattatggtt agtacaaata ttagtttgct ggcctggaaa gaatatttta
    26761 atggatttgg gaatcacttt tagagaagaa agcatttcct ttacttctga agtacttaat
    26821 attttaaatt tctgcatatt atttaccacc caatatacct attttttttc tgttgtaaac
    26881 acagtaatat gtatgacgtg ctaaagttct catctttttt tccaattccg tattgggacc
    26941 aaataatcga ttcatgttca tatgcagcag actgtccagt atgcttaatt ttacagcttt
    27001 gttatccggg taatattttt caattctatt taaatattct atcattgatt cttgttttac
    27061 cgatagtagt ttcaaaataa attcaatctc tggatctaac gtttcatgat acaaatactt
    27121 tattacgaaa tcaacgtagg tttccttatg ttttttaaat tctttttgat agctcttggt
    27181 aggattttca caattgagaa atacaaacat atcctcaaaa ctcaaattaa atgtttgcat
    27241 gtgaaagaaa ataatcactg atgctaaaag ttcatctgtc acttttatat tatgattatt
    27301 tttttcatag attatggttt gaattgctat gctgtctttg aaaaacactt catgtgcata
    27361 gttcatcaaa tcatacccgc cataccgctc taattcaagc tcgtaacaat taatactata
    27421 gtttgagatc agagattttt tcatgagctg gcttaatata tctaacattt tgggcaatac
    27481 catcattaat ctggtattat cagcttttaa tctcaaccgc agatgtaaat caggatcttt
    27541 atactgaatg aagaaatagc tgtctatctc tttattatca agtaaattct gcaatggagc
    27601 atacaaagct tcacctaaca gataatctgc atattcctca ataccgtata ttttgaaata
    27661 tagccactca tccaaaggct ctttatatct ggcattacca taattcctgg taatgtcaaa
    27721 atcattggtc ttatgggggg tagcatcctg agctaaaatt aatggtatta ccaattcaca
    27781 gcaataagaa ctatcattca gtttcactgg atgttctgat tctatatgat atctttctac
    27841 aacagtttct gatttttcca gtaatttctg caacacagat aaacatctgt cctctttcag
    27901 atttaacaga agttttttgt ctgcatctac agcatccacc caaaggggta tatttcttga
    27961 atttatgtat tcggtaaact tatttttaaa ctcagcaaaa tcataatgtt ttgttaaacc
    28021 cagatcgcct attttaataa tccatttttc ctgctccaat acgaagtttt tatatcgtat
    28081 tgttggaaga taggcaaact tctccattaa gtattgccat ggtttattat aaaacctgat
    28141 tccatcagaa gaaatttcgt caataaatcg taatattctg ggttttaact gcggattaaa
    28201 catattggta gatgttggga tgattctttt attgttaacc gcagacttta aatataattt
    28261 gttgttttta aattctacta aaatttcatt taacttaagt ttaaatgcct gatctttgga
    28321 atttgtagtg ccaaaacttg tttcataagt ggaaccatgc atatttcgga tcacgtttgc
    28381 ggaatataaa ctatcgggta agtaggtaaa ttcacagacc tggcattcat caccataact
    28441 tttatttatt tcttaaagaa ttgttccgga ttcttcatta ggtgagaaaa tcttccaaat
    28501 gattttcctg cataagtgga cccaaaaata ttacttaaat agtagacatc tcttccattg
    28561 tcttttacat aattaaagta gatttccata gatttgggca actgattcat atcaatatct
    28621 tccgttaata gcattcccat atctgaatcg gttatctcaa tttcctgacc aagtctaatg
    28681 gattcaacat attttctttc aaaaaatcgt atccaggggt tgatatactc tcccaaatta
    28741 ttcatgccgg ttttttccat cataatgggc tggaaaaccg attcctgtat cagggtcaat
    28801 gagttcagtc aaaggaacac acctggaaag gccatatttt tctagaaatt tgttcttgta
    28861 atcattcaaa ctattgaaag gctctttgat attaaattgt ataaataaat tgagaagctt
    28921 atttattttt tttatttcat tttgatttaa attgcactcg ctgtaggaga aggaggaatc
    28981 aatggtcagg tagtttttgg agttgtagat tctcttcata tctttgaaaa tctgcgtcag
    29041 gcattcgatg gtattattta tatagccatt ggaatattcc tgtatttcat tttttatgtc
    29101 aactaatgag ttagtattta tattgtattc ctgaagttta cagataaagt attcaaattg
    29161 gtcgacgatt gttaatggtg gacgaagatc ggatattaaa taaccttctt ttatgagtga
    29221 ttggatatat gtatgaaatg tgttttcttc cacattcgga tattcttttt taaggttctc
    29281 tataatatca gtataactta cgtaatcacc tgatattctt aaaactactt caaatgcatt
    29341 ggagtacttt acagattttt tatttacttt tcccccatcg ctgtcttttg tgcagttgaa
    29401 taagattgct ttgtttctct gaatggcaac actttcattg attgtgtatc ggagggattt
    29461 taggtacttg gattcgtaca taaaaaccac ttggtataac cactctgaat caatcagggg
    29521 attccttttt aattctggac tgcttaattc aaatgatgtt ctgtcagatg taatattgcc
    29581 aaatgcaacg gtcgaaaata atccaaatgg agtacacctg gaacagcttc tgctaaaata
    29641 tttatagatt gaatttaaca aataatttgt atcccttgct gtgccatcct ctatataatg
    29701 ctgcatggat tcatataaat cttggctggc cacaaatata gcttcattaa actgatcttt
    29761 atattgagga gaatcaaata aaaacatagt ttgatctatg ttatttgcat tttctatatt
    29821 atctgtcaat aaattaattg gcagacccgg tgttcttatc ataaaggaac ctatatcttt
    29881 aaataaatct ttcatatttt aaccgtatcc cccttgctta gctcttgtat gcctgaccaa
    29941 attagaaact taatattcac cagtaaatta cttccacaaa atgtaaacgt acatgcattt
    30001 tgtgaatctt ctaaatgcat gtacgtttgc atcgggttta ggtttacatg gaaattagta
    30061 gcataaccat gtgtttgtgc aatttcttgt cattccacat tcacttgttc cacaggtagt
    30121 tcctgttaaa caaccaggtg tgcaataagc aacactagca atttttgatt ctcctacatc
    30181 tactgaaccc ttgtccattt taagatctaa atcaaaatct ttattcatgt cctcgtcccc
    30241 ctttctatgt agttatataa tctgaatttg atcatatata gtaaacgtga aatgaatcac
    30301 tttactacca agttcatgtc tgtattatat caaaaaatat actctgtttt gactgcatgt
    30361 aatttttacg actttacatg taattttcaa tgagggtgtt tatgtaatga gggttatggt
    30421 gggttatggt gggttatgat atctataatg caaatgctgg caaaaaaact gcgctaagct
    30481 gattaaaaag ctgtgcgcag aatattattg aacgatactt tgtgttgttt gggaagattt
    30541 ttatcaatct atttttacaa tatcaaatag aaagggaaac ttttctgcag ttttattttc
    30601 gaagtcgact ttgtacccag ttccgtcttt gtaaaataaa ccctggttta aatccactct
    30661 gatgtaacac atattttcat cattttcatt gttatgggca aaataccatg gctcaaatac
    30721 cttaattagc ttttctctga ttttaagatt ttccggtaat aatggatgtc cgatatttcg
    30781 ggcaattccg gtaaaacgat acagatcttt acttaatgaa actataggat tttgctcgat
    30841 atcttttact ttatcagact taccgtaagt tacaatataa aatgctctat tattataaaa
    30901 aagtatcgat aaaccttacg gctggaatgt tattgtttga tgtggccagt gcaaattgat
    30961 agtctctggc aaataatgta tctaaaactc caagtccttc ttcatacgca ttcatttgtc
    31021 ttgtctctta tttccttaat attttttcca ttactctgcc tttggcaagc tcatctatta
    31081 atttgtccag atacctgatc tgcctcatta actcatcttc aatctcttcc actcggtatc
    31141 cgcagatcac tcctttgatc agtgacgcat tagggtttat gtgaggagct tggcggaaaa
    31201 agtcttccac acttacttcc ttctctattt gctgttgtaa tgaattggta tcatagcctg
    31261 tgagccagaa aataatttca tctacttctt ttctggttct tccttttttc tctgcttttt
    31321 ttatataaag cggataaatg cttgaaaagg gcatatgaaa gattcgcggt gtctccatca
    31381 gatgatctcc tttatataaa ccctttggct tctttccaat ctatgagaag attgtatcgg
    31441 cttgtggtga aacgtaaaac gcagtaattg ggatcctccc atccactgaa atgattctcc
    31501 agtccacggt accacatctc tcatttcagg gtctgttatt acttctattg tacccactaa
    31561 tgtgatatta tgatcaattg aattaaaaca gatactggct ttgttgctca gatcaattcg
    31621 tttggttcta ttacttccta aaccggtaca aaatgtgagc cagttgatgc cgtcagcttt
    31681 tgatacggat atggttgagg ttgttggaaa gttgtcagtg tccattagtg ttagggcgca
    31741 gtatcctttt tcttcacctg cggtgttggt ggcaatgatc tctcctgctc ttgcaatgat
    31801 ttcttcgttc atttgatttt cctcctgatt ggttatggat atagtatata ataatggata
    31861 ggacaactgg gtgtcatgtt caaaacgggg ggataaaaaa attgagtccg taactccgtc
    31921 gtgccgatct cgattccgct tacgctccat ctcaatcgcg ggcttcgccc tataaaaata
    31981 agtgccataa agtccggttg agagcaagct ctcccccgga ctttttgaca cttatttttg
    32041 cacgactcat tgccaacgcg ttaattattc aacgccgcct gtgctgctgc cagtcttgcg
    32101 atcggcacac ggaatgggga acaggataca tagtcaagtc ctatcttatg gcagaattct
    32161 acggaagaag gatctccgcc atgctcgcca caaataccaa cgtgcatgtc aggacgaacg
    32221 cccttgccta acttgatcgc tgtctccatc agcttgccta caccagtctg atccagtttt
    32281 gcaaatggat cattttcaaa gatcttggta tcgtagtagg agtttaagaa ctttcctgca
    32341 tcatcacggg agaagccata ggtcatctga gttaagtcat tggtaccgaa gcagaagaat
    32401 tctgcatctt ttgcgatatc atcggctgtc agtgctgctc tcggaatctc aatcatggtt
    32461 cctacctgat aggttaaact gctgcctgct gctgcaattt ctgcatctgc agtctcaaca
    32521 acaatcttct ttacaaatct taattctttc tcatcacaaa tcagaggaat catgatttca
    32581 ggacatacgt tccagtctgc atgtgctttc tgaacgttga tagcagcacg gattactgct
    32641 tttgtctgca ttcttgcgat ctctggatag gtaactgcaa gacggcagcc tctgtgtccc
    32701 atcattgggt tgaactcgtg aagagaatca atgattgtct tgatctgctc cacagtcttg
    32761 ccctgtgtat cagccagctt cttaatatca tcttcctctg tgggaacaaa ctcatgaaga
    32821 ggcggatcta agaaacgaat ggttactgga tttccttcca gtgcctcata aagagcttcg
    32881 aaatcgcact gctgtaccgg aagaatcttc tccagagctg cttctctctc ctcaacagta
    32941 tcagaacaga tcatctcacg gaatgcatca attctttcac cttcaaagaa catatgctcg
    33001 gtacggcaaa gaccgattcc ctctgcacca agttctcttg cttttcttgc atcagcaggt
    33061 gtatctgcat tggttctgac tttcagtttt ctatacttat cagcccatgc cataattctt
    33121 ccaaactcac cagcaacggt tgcatcaaca gtcggaatga ttccgtcgta aattttaccg
    33181 gttgatccat caagagagat ccagtctcct tcatggtatt ccttacctgc aagaacaaac
    33241 ttctttgcag cttcattcat ggcaatttca gaacagccgg atacacagca ggttcccatt
    33301 cctcttgcta ctacggctgc atgagaagtc attcctcctc taacagtcag aataccctga
    33361 gctgccttca ttccttcaat atcttcagga gaggtttcaa gacggactaa aaccaccttt
    33421 tcccctcttt ctttccatgc tttcgcatca tcagcggtga acacgatctt tccgcaggca
    33481 gctccaggag aagcagcaag tgcctttcca accggctctg tcttctttaa tacttctgcg
    33541 tcaaactgag gatgaagcag agtatctaag tttctcggat caatcatctt aactgctttc
    33601 ttctgtgatc ataaattcgt ctactaaatc acaggcaatt tttaaagcag cctttgctgt
    33661 tctcttaccg ttacgggtct gaagcatata aagcttcttg tcctcaatgg taaactccat
    33721 atcctgcata tctttgtagt gatcttccag gatactgcag attcccacaa atttatgata
    33781 aacttcaggc ataacttctt ttaactgttc gatcttctgg ggagtacgaa caccggcaac
    33841 tacgtcttcg ccctgggcat tcattaagaa ttcacccatt aagtgttttt tcaccagttg
    33901 caggatcacg ggtaaatgca acgcctgtac cggaagtctc acccatgttt ccaaatgcca
    33961 tcatctgaac gttgacagca gttccccagg aataaggaat atcgttgtca cggcggtaaa
    34021 cattggctct tgggttgtcc caggaacgga atactgcttt gattgcaccc attaactgct
    34081 ccttgggatc agttgggaaa tcgagaccaa tcttttcctt atattctgct ttgaactgtc
    34141 ttgcaagctc tttcaaatcg tcggcattca gatccacatc ctctgtaaca cccttttttt
    34201 ctttcatttc atcaatcagt tcttcgaagt attttttgcc tacttccata actacatcgg
    34261 agtacatctg aataaatctt ctgtagcagt catatgccca gcgtggattg cctgattttt
    34321 cagcaagtac ttccactacg tcctcattaa gtccgagatt taaaattgta tccatcatac
    34381 caggcatgga agctctggct ccggaacgaa cggaaaccag aagaggattt tcattatcac
    34441 caaatttctt gccggtgatt ttccatcttt tcgatatgat ccatgatctg ccccatgatc
    34501 tcgtcattaa tcgtttcccc atcttcataa tactgagtac atgcctcagt cgtaatcgta
    34561 aatccctgag gaaccggcag acctaaattg gtcatctctg ccagattcgc ccctttacca
    34621 cctaacaggt ttttcatatc tgcactaccc tcagtgaaca aataaaccca ttttcttgcc
    34681 ataagtaaaa tcctcctcaa atgtgtaaat tatgctgctc ccccgcgctt tccattgcgg
    34741 aaaagccctg aaagtattat agcacaatta aaggggtagt aaagaggttt tcatagatta
    34801 tttaaagtaa ttatctcttt tttaaataca attgtattga aagtacttac aaagtctgtc
    34861 tttttccgat atgcgattta tgttcgtata tacgaaatta cgttcgacaa aagctctgtt
    34921 tctttaacaa aattcgacat gccacaaggg tcagtatctc tgtcacaggc atgaccgtcc
    34981 agattccggt aactcccata aaaatcggaa gaataaagac cagaatactg tttaaaataa
    35041 ttccccgaag cagacagatc tttaatgcat ttcccggttc catcacagac tgaaaccagg
    35101 tggtatacag tacattcagt cccattgctg caaaagacag gaaatagatc cgaatggccg
    35161 gaactgacat agccagaatt tccttttcag gtctgacaaa tgcttctgtc acaagagccg
    35221 gaaacaaaag tcctgttaca gcaaacaaca caccggataa acaggcggta cgctctgcca
    35281 gatgtcttac ttcctttaaa cggtcttttt tccccgcacc gtaatttgtc gccagtatgg
    35341 gctggactgc ctgtgaaata ccgttattaa cagatgatgc gatataggca ctgttggaga
    35401 taataccata tacaaccacg ccaagttccc ctgcaacaga aaggatctga cggttaaata
    35461 agaaggttac gattccattg cacatatcca gtaaaaagct ggagaaccca tttttcacta
    35521 cagccacagc ctgactgaga tgaaagcctg aaacaaattt taaagtattc ccttttgaaa
    35581 tcaggtgggt cagcaatatt aagagtgtca cacaggttcc gatcacagtt gcagcggcag
    35641 ctcctgccat tcccatattt aagggaaaca tcaatatata atccagaata atatttaaaa
    35701 ctcctccgca aaccactgct gtcatagcca ggcggggagc tttatcgttt cgtacaaata
    35761 cctgataaaa agaagcaaat aaaaaggcgg gagctcctgt tatgaggatt cttccatatt
    35821 cagttacata aggcgtcatg ttttcatttc tccccagaaa acccgtaaca ggcaggaaaa
    35881 atgcatgtcc aagaactaca taaatcacgc tgattcctgc agccataata aatgccactg
    35941 tataatactg atttgctcct gattcatctt ttttcccctt acagacggac agaagtatgc
    36001 caccccctgc cccaaacagc ataccggttg caaaaaaaag gctgaataag ggcagcagta
    36061 tatttaaagc cgcaattcca attgctccaa ctcctcttcc aatcataaga gtgtctgcta
    36121 atatataaat ggaggtaacc attgttgcac taattgatgg aagaagataa cctgcaaata
    36181 attttttaac aggatcttcc agtaaattta ctttttcata attaagtctc cttttgaaag
    36241 tcttaaaata gtttaccata atttaattaa ataacaagga aaagaacgaa agtatgattt
    36301 aacatttaaa agtcggggca tatatattaa aatgacagaa ttttttatct tagtttttat
    36361 gcaaaatatc atgaattaag attgtttcca acgctgaaat atgatacatt agtgttatct
    36421 ctgaaaatat attaataaca ggaggaaaga tcgtattatg aaaaaaagag ctctcgcatt
    36481 agccatggca gtaatgatgg ccgcaacact cagcgcatgt ggttccgctg gtaaaggaac
    36541 cgctacaact gctgctccat ctgcagaaac cacaactgct gcagaaaaaa cagctgaaac
    36601 tacaggtgct acatccgtta agtctgattc ttctaccgga tatgaacttg cgctggttac
    36661 agaccttggt accatcgatg acaaatcctt taaccagggt gcatgggaag gtatgaagaa
    36721 gtacgcggaa gagaacaaga tctcctataa gtactatcag ccacaggaag gtactactga
    36781 ttcttattta gaaacaattg gactggctat tgaaggcggt gcaaaattag tagtatgtcc
    36841 tggcttctta tttgaagagc ctgtattcct tgctcaggag cagtacaaag acgttcactt
    36901 cattcttctt gacggagttc ctcataacgc agactactca gaatataaga cagaatccaa
    36961 tgttatgcca atcctgttcc aggaagatga gcctggattc ttagcaggct atgcagcagt
    37021 aaaagaaggt tacacaaagc ttggtttctt aggtggtatg gctgttcctg cagttatccg
    37081 ttatggttac ggatttgctg aaggtgctga ttatgcagct aaggaaatgg gcattgacgg
    37141 cgttgaaatt atgtacaact acacaggtgc tttcgctgca actccagagg ctcagtctat
    37201 ggctgcatcc tggtaccaga acggaactga cgtaatcttt ggctgcggcg gtgctgttgg
    37261 taactctgtt atggctgctg ctcaggaaaa gggcaaaaag gtaatcggtg ttgacgttga
    37321 ccagagctac gaatctgaga ctgtcattac ttctgccatg aagcagcttt ccgtatctgt
    37381 atacgacggc gtaaaagact tctatgacaa caagttccca ggcggcgaga caagcatctt
    37441 ctccgctaag aataatggta tcggccttcc tatggaaact tccaagttca ccaaattcac
    37501 aaaagaagat tacgaaaaaa tcttcactga attaaaggat ggcaaagtaa ccctggtaca
    37561 gccttctcag gataacaacg atccgaacaa agacttaaag cttgaaaaaa caaagattaa
    37621 ctttgtagaa taatccgcgg ggatagtgcc ctccgggcat accacgatgt cagaattctg
    37681 acataaaaaa ggaaaggaga tgccgtttga ttcaccagtc agtaaagatc tggtctctta
    37741 cggcatcttc tttttgcttt aaaactttat taaccgggta ccgggtccca tagataggta
    37801 ccatagtaag ggggatttta tggactacat tattgagatg cttcatatca caaaagaatt
    37861 tcccggtatt atcgccaatg atgacattac actacagtta aaaaaaggcg agatacatgc
    37921 cctcctcgga gaaaatggag caggcaaatc aactcttatg agtgtattat tcggattata
    37981 tcagccggaa aaaggctcaa tccgggttcg tggtaatgaa gaaaaaatca ctggtccgct
    38041 ggatgccaac gcacttggta tcggcatggt gcaccagcat tttaagctgg tagagaattt
    38101 cactgtcctg cagaatatcg tactgggcat ggagacgaca agacggggct ttttgaagat
    38161 ggatgatgcc cgcaaaaaag taatggaatt aagtgaaaaa tacaaattgt tcgtagaccc
    38221 tgatgcgctg atatccgata ttaccgtagg tatgcagcaa agggttgaaa tcttaaaaaa
    38281 tgctgtatcg tgataacgaa atcatgatat ttgatgaacc taccgcagtc ctgactcctc
    38341 aggaaattga tgaactgatg cagatcatgc gggatctggt aaaggaaggg aagtccatac
    38401 tgttcatcac acacaagctc aatgaaatca aggcggtagc agaccgctgt tccgtcctgc
    38461 gccgcggtaa atatattgga accgtagatg ttgctgatac tacgcgggaa gagatgtcag
    38521 agatgatggt tggccgtaag gtaaacttaa ccattagtaa aaaaggcatc ggagcctggt
    38581 gaagtagttc tggaagtaaa agatttatcc gttgaagcca aacgggaagg acaaaccaaa
    38641 aagctggttc atgatgtgtc atttcaggta agaagaggtg agattgtctg tatcgccggt
    38701 attgacggca atggacagac agagctggtt catgcaatta ccggtatttc agatcccagc
    38761 tccggttctg tcaccattaa tggggaggat atgacgaaaa aaagtatccg ctacaaaaat
    38821 acccatggtc tctcccatat acccgaagac cgtcataaac atggcttggt actggaatac
    38881 aatctggcat ataacctggt tctccagcag tattttgaca aagaatttca gagcggcaca
    38941 tttttaaaga atgaccagat ctttgactat gcacaaaaac tgattgaaaa ttatgatatt
    39001 cgaagcagcg aaggggcatt caccaccacc cgaagcatgt ccggcggcaa tcagcagaaa
    39061 gccatcgttg caagagaaat ctccaaaggt cctgatattc tccttgcagt ccagcctacc
    39121 agaggtctgg atgttggtgc cattgaatac attcacaacc agctggtaaa acagcgcgat
    39181 gcaggtgccg ctattttgct ggtatctctg gaattagatg aagttatgaa tttaagcgac
    39241 cggattttag tcatgtttga aggcggaatc gttgccgact tagatcctga gaacattacc
    39301 gttcaggaat taggacttta tatggcaggc gctaagaaag aaggtggcac actatgaaac
    39361 cgaaacagat aaaagatcat acaggcatcc tctcttccat attcgctatt attctgggac
    39421 tcattgtagg gctgattatc ttgtttctgt gtaatccaga acaggcactt cccggatttg
    39481 ctacgattct gagcggagcc ttcacccacg gagccaaagg tgttggtcag gtattttatt
    39541 atgccacacc gattattctt accggtcttt ccgttggatt tgcatttaaa accggacttt
    39601 ttaacatcgg tactcccggc cagtttatta ttggaggctt cggtgcggtt tacgtaggaa
    39661 ttctctggac ctctctcgga ccggctcact ggattgtagc tttggcagca agtgtaatcc
    39721 ttggcgcctt atgggggctg gtaccaggta ttttaaaagc gtactataat gtaaatgagg
    39781 ttatcgcctc tattatgatg aactatattg gtatgtatct tgtaaactgg attacgaaaa
    39841 gctataagcc gctgtttaac aatttaagaa acgaatccaa gaatgtggcg aatac
//
