LOCUS       NZ_CP070499            25182 bp    DNA     circular CON 28-MAR-2024
DEFINITION  Natronosporangium hydrolyticum strain DSM 106523 chromosome,
            complete genome.
ACCESSION   NZ_CP070499
VERSION     NZ_CP070499.1
KEYWORDS    RefSeq.
SOURCE      Natronosporangium hydrolyticum
  ORGANISM  Natronosporangium hydrolyticum
            Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
            Micromonosporaceae; Natronosporangium.
REFERENCE   1  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Natrosporangium hydrolyticum gen. nov., sp. nov, a haloalkaliphilic
            actinobacterium from a soda solonchak soil
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 5699854)
  AUTHORS   Sorokin,D.Y., Khijniak,T.V., Zakharycheva,A.P., Boueva,O.V.,
            Ariskina,E.V., Hahnke,R.L., Bunk,B., Sproer,C., Schumann,P.,
            Evtushenko,L.I. and Kublanov,I.V.
  TITLE     Direct Submission
  JOURNAL   Submitted (17-FEB-2021) Bioinformatics, Leibniz Institute DSMZ,
            Inhoffenstr. 7B, Braunschweig 38124, Germany
COMMENT     ##Genome-Assembly-Data-START##
            Assembly Date                     :: 26-MAY-2020
            Assembly Method                   :: HGAP v. 4
            Assembly Name                     :: 999_Micromonospora_sp_DSM106523
            Genome Representation             :: Full
            Expected Final Version            :: Yes
            Genome Coverage                   :: 580.0x
            Sequencing Technology             :: PacBio Sequel
            ##Genome-Assembly-Data-END##
            ##Genome-Annotation-Data-START##
            Annotation Provider               :: NCBI RefSeq
            Annotation Name                   :: GCF_016925615.1-RS_2024_03_28
            Annotation Date                   :: 03/28/2024 06:45:28
            Annotation Pipeline :: NCBI Prokaryotic Genome Annotation Pipeline
            (PGAP)
            Annotation Method :: Best-placed reference protein set; GeneMarkS-2+
            Annotation Software revision      :: 6.7
            Features Annotated                :: Gene; CDS; rRNA; tRNA; ncRNA
            Genes (total)                     :: 5,188
            CDSs (total)                      :: 5,131
            Genes (coding)                    :: 5,046
            CDSs (with protein)               :: 5,046
            Genes (RNA)                       :: 57
            rRNAs                             :: 2, 2, 2 (5S, 16S, 23S)
            complete rRNAs                    :: 2, 2, 2 (5S, 16S, 23S)
            tRNAs                             :: 48
            ncRNAs                            :: 3
            Pseudo Genes (total)              :: 85
            CDSs (without protein)            :: 85
            Pseudo Genes (ambiguous residues) :: 0 of 85
            Pseudo Genes (frameshifted)       :: 18 of 85
            Pseudo Genes (incomplete)         :: 72 of 85
            Pseudo Genes (internal stop)      :: 4 of 85
            Pseudo Genes (multiple problems)  :: 8 of 85
            CRISPR Arrays                     :: 3
            ##Genome-Annotation-Data-END##
            ##antiSMASH-Data-START##
            Version                           :: 8.dev-cf2fc5ee(changed)
            Run date                          :: 2025-09-13 08:11:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start                       :: 4871697
            Orig. end                         :: 4896879
            ##antiSMASH-Data-END##
            REFSEQ INFORMATION: The reference sequence is identical to
            CP070499.1.
            The annotation was added by the NCBI Prokaryotic Genome Annotation
            Pipeline (PGAP). Information about PGAP can be found here:
            https://www.ncbi.nlm.nih.gov/genome/annotation_prok/
            COMPLETENESS: full length.
FEATURES             Location/Qualifiers
     region          1..25182
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="lanthipeptide-class-i"
                     /region_number="21"
                     /rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /tool="antismash"
     cand_cluster    1..25182
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..25182
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="False"
                     /core_location="[10000:15182](+)"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..15182
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(((Lant_dehydr_N or Lant_dehydr_C) and
                     cds(LANC_like and not Pkinase)) and not (YcaO or
                     TIGR03604))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     gene            complement(318..776)
                     /locus_tag="JQS43_RS21960"
                     /old_locus_tag="JQS43_21880"
     CDS             complement(318..776)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013736473.1"
                     /locus_tag="JQS43_RS21960"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21880"
                     /product="DUF3307 domain-containing protein"
                     /protein_id="WP_239676262.1"
                     /transl_table=11
                     /translation="MSAGYEAAAVVGAVFAALYAAHMVGDHFVQTQHQADHKGLPGWRG
                     RVACLGHVVSYTATGVVALLVLVLGTGLTLDPWRVAAGLAISAVTHYIADRRTPLRRLA
                     EATGSARFYLLGVPRPGRDDNPSLGTGAYALDQSWHIGWLFVAAVVIA"
     gene            complement(773..1369)
                     /locus_tag="JQS43_RS21965"
                     /old_locus_tag="JQS43_21885"
     CDS             complement(773..1369)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS21965"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21885"
                     /product="hypothetical protein"
                     /protein_id="WP_239676263.1"
                     /transl_table=11
                     /translation="MNPRYDEVTSAAVRPELASAAGPAPSEYDYRGDAEKTAVVEDAAA
                     EWADYVSEYAAEVAAEEGDTERPIVADAIKALSAWGVDLAPDSAATLLRSWRRADQLTP
                     EQVAEVAARFSGADPGDRGPSPEVVELETGGWRTTIEVSPRVRVVVTEDIGRTGHTGLT
                     VELGSGEHITVALPSRAVDAVAAALTAAGRAEVAR"
     gene            complement(1443..1844)
                     /locus_tag="JQS43_RS21970"
                     /old_locus_tag="JQS43_21890"
     CDS             complement(1443..1844)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS21970"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21890"
                     /product="hypothetical protein"
                     /protein_id="WP_239676264.1"
                     /transl_table=11
                     /translation="MTQGHLGQSHPLAVVASRHCRHGVPVPLLVGGVACGACWELAIRD
                     DERVVVEHGLPRELVPDPDHVDEVAVRLACRGEPVELTAAERAEAARVLAGRGVSAWEI
                     RRRLRQPRSGVVVEFRRRPSVSAGLADAA"
     gene            2046..2909
                     /locus_tag="JQS43_RS21975"
                     /old_locus_tag="JQS43_21895"
     CDS             2046..2909
                     /GO_function="GO:0003700 - DNA-binding transcription factor
                     activity [Evidence IEA]"
                     /GO_process="GO:0006355 - regulation of DNA-templated
                     transcription [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1136: GntR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013730716.1"
                     /locus_tag="JQS43_RS21975"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21895"
                     /product="GntR family transcriptional regulator"
                     /protein_id="WP_239676265.1"
                     /transl_table=11
                     /translation="MSSPRPPLEPSESRTRQVARNIRTDIEAGVLRHGDVLPSTRELAT
                     EWGVSPFTISEAMKLLAADGLVLSRSRAKRVVNAPAQARRTEIRGSTPHVIVIGGYAGS
                     GKTELGRILVRETGWPLLDKDTLTRPVVETALESVGRSPHDRDSDYYMKEIRPREYEAL
                     AAATKENVECGNSAIVTAPFIREFSDDAWVKRIQAVHSAMNATTTFVWVYCDPETMHTY
                     LRRRGAARDSGKLSDWPGYLSVIDVDFRPSVPYHLIDNSEAAAPLHDQARELVRTVMAD
                     NIGSTK"
     gene            2945..3544
                     /locus_tag="JQS43_RS21980"
                     /old_locus_tag="JQS43_21900"
     CDS             2945..3544
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013476531.1"
                     /locus_tag="JQS43_RS21980"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21900"
                     /product="bifunctional 4-hydroxy-2-oxoglutarate
                     aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase"
                     /protein_id="WP_239676266.1"
                     /transl_table=11
                     /translation="MVILRGLPSPTAAVAAASRAWDSGVELVEVPVERPELVSSLAAVV
                     AAGAERGKGVGAGTVITGDQVRAAAAAGAQYTVAPGLDLAVMAASRAAGIPHLPGAATA
                     TEVQHAKAAGCDWVKVFPAGTLGTAWFRAMQGPFHTMNFLATGGVSLAAAPDYLAAGVR
                     VVAFGAAATDAEHRQHLRDLVTAPMRAAVNGCQRAR"
     gene            complement(3624..4262)
                     /locus_tag="JQS43_RS21985"
                     /old_locus_tag="JQS43_21905"
     CDS             complement(3624..4262)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS21985"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21905"
                     /product="hypothetical protein"
                     /protein_id="WP_239676267.1"
                     /transl_table=11
                     /translation="MKAKKETSKAQLTVAVLIVVALLLLIGAFLFSALRFFVRADPTVV
                     AAMMGASATVIVATLTVVGGRVFERKKAIEAEQRTQWAKLYEEFIREWLKIMQLNIPKE
                     KRVEKVDDSAVVEYFANFSAKAMPWASAQVLNQWIAFRQLTVQGSAGDKGRGKQLLFEW
                     EKLILAMRRDLGHKDKSLDDHQILKMFINDLDESIGKKEETQSQPERAG"
     misc_feature    complement(3786..3788)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    complement(4161..4163)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    4257..4271
                     /note="TFBS match to CodY, Regulator of stationary phase
                     and virulence in Gram-positive bacteria, confidence: weak,
                     score: 17.12"
                     /tool="antismash"
     gene            complement(4925..5092)
                     /locus_tag="JQS43_RS21990"
                     /old_locus_tag="JQS43_21910"
     CDS             complement(4925..5092)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS21990"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21910"
                     /product="hypothetical protein"
                     /protein_id="WP_239676268.1"
                     /transl_table=11
                     /translation="MDLAAVALPYADGPRPGGPAYFRVEDGLVHHRLCSRARAVAEIES
                     GLGGLPGRYV"
     gene            complement(5161..5514)
                     /locus_tag="JQS43_RS21995"
                     /old_locus_tag="JQS43_21915"
     CDS             complement(5161..5514)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS21995"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21915"
                     /product="hypothetical protein"
                     /protein_id="WP_239676269.1"
                     /transl_table=11
                     /translation="MITQRRWDLRGVGKHKPRLRGGDRLWQCRCGDPWPCAAARRRLLI
                     RYGYGRRLGELAFELLEQAVRDLPHLSVSQLYDRFIAWTLPPEPALCRQHDPGGGTRPC
                     RGSWPPRCAPDRP"
     gene            complement(5514..5960)
                     /locus_tag="JQS43_RS22000"
                     /old_locus_tag="JQS43_21920"
     CDS             complement(5514..5960)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22000"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21920"
                     /product="hypothetical protein"
                     /protein_id="WP_239676270.1"
                     /transl_table=11
                     /translation="MPSPGGSVPALKTTGPAALGGVMERRGHQVAALVRLARHSGQGAV
                     ERSLAGRDAEMLAALLSDAVAMMAGQPREWDEEDLLESQRQFERGDGVVEAQVALCRRR
                     LADGSGPAELVAHMTRTYSLWEEHGAQLAARAVLALSVSERGRP"
     gene            complement(5953..6219)
                     /locus_tag="JQS43_RS22005"
                     /old_locus_tag="JQS43_21925"
     CDS             complement(5953..6219)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22005"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21925"
                     /product="hypothetical protein"
                     /protein_id="WP_239676271.1"
                     /transl_table=11
                     /translation="MAEVAAGAGSGQPRMLLLVALQAAVEAGDADRCCRVLLAAARGLA
                     AEGHRREAQRVLNLAQAHLGAKDCLRADLAAAWREFEQEESNA"
     misc_feature    complement(6028..6030)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    6414..6428
                     /note="TFBS match to VqsM, Regulator of quorum-sensing
                     signalling systems, confidence: medium, score: 17.88"
                     /tool="antismash"
     gene            6663..6986
                     /gene="cutA"
                     /locus_tag="JQS43_RS22010"
                     /old_locus_tag="JQS43_21930"
     CDS             6663..6986
                     /GO_process="GO:0010038 - response to metal ion [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="cutA"
                     /inference="COORDINATES: protein motif:HMM:NF015077.4"
                     /locus_tag="JQS43_RS22010"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21930"
                     /product="divalent-cation tolerance protein CutA"
                     /protein_id="WP_239676272.1"
                     /transl_table=11
                     /translation="MTDLWNVSTAVEDRQAAEVLAESALMAKLAASAQLVGPVGSMFWH
                     HGEFGSAQEYQVIFRTTASCYQALQQHLIDNHPWKNPEVTAVSLAAASPQYARWVEQTV
                     AED"
     gene            complement(6913..8154)
                     /locus_tag="JQS43_RS22015"
                     /old_locus_tag="JQS43_21935"
     CDS             complement(6913..8154)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018740010.1"
                     /locus_tag="JQS43_RS22015"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21935"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_239676273.1"
                     /transl_table=11
                     /translation="MRELRKQRNISFRDLARLTLASKSKLYQIETGRVVPDAETAQLID
                     NALNACGDLARLAQLGQEGQPAPLLPRREFLGVAASAVALAPLMDHLKAGRQLGGNLVR
                     QLLMNTARLRRLDDYFGGADTYELFAEEVEATALLLHEGSYPEATGRQLLALLSEQAQL
                     AGWAAFDAGWQPQARHMYELSLQAAQEAGDPSLTGNAFAFLGYQRLTVGEPPIEDLTAA
                     CEWAERGSPPKVRTLLHCRRAWAHANIGDASQTQRHLDIAADALTVSAQAAEPDWVYWV
                     DGLEHDIMTGRCWAALRRPLRAIKALEDALDCYDDTHGRDKGLYLSFLADAYLEANEIE
                     QACAVASKAMDLCAGVGSVRPHERIRNLIGRMEPVQPAVADLRTRAEQVFNLRQLSAPP
                     TGRTAVTLQPGTRR"
     gene            8450..9676
                     /gene="fxlM"
                     /locus_tag="JQS43_RS22020"
                     /old_locus_tag="JQS43_21940"
     CDS             8450..9676
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018789023.1"
                     /locus_tag="JQS43_RS22020"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21940"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_239676274.1"
                     /sec_met_domain="PCMT (E-value: 4.3e-37, bitscore: 126.1,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTDDKTARSRDTLTDRLKADDMIRSEAVEAAFRRVPRHLFVPAGT
                     SIEEAYSADAAPPTKKDVEGQIISSVSAPFLQAQMLEQAQLHPGASVLEIGSGGYNAAL
                     IAEVVGPAGRVVSVDIDPDVTAWAREALDASGYGNRVETVCADAEHGLAGSSVFDAIIV
                     TVGAWDIPPAWLTQLDHDGTLSVPLRMNGVTRSIAFARQADHLASTSAEVCGFVPMQGL
                     GERRERVLQLPDGHGRYVRLRFDTGAPEDPNLLDGVLADMKVRVWSGVEFPNGVSFADL
                     HLWNACFLPGFCKVAADEGTELAQDRKSWFPFGCVFIDSFAYLAVRPAMDGAGIEFGAG
                     AYGPNGEQAAAAMVEQIQAWDRRARRGPVPTFGFWPDGSDRSHIPDHVALLEKHHGLVT
                     VSWPRASRP"
     gene            9731..9919
                     /locus_tag="JQS43_RS22025"
                     /old_locus_tag="JQS43_21945"
     CDS             9731..9919
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) LD_lanti_pre"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04363.1"
                     /locus_tag="JQS43_RS22025"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21945"
                     /product="FxLD family lanthipeptide"
                     /protein_id="WP_239676275.1"
                     /sec_met_domain="LD_lanti_pre (E-value: 4.7e-15, bitscore:
                     53.5, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPPVLMLDEADTSTPIPDEEFELDLRVVQTTAAVTSMRCDTSDNC
                     GATCGTSACNSGSLDPS"
     CDS_motif       9731..9844
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence:
                     MPPVLMLDEADTSTPIPDEEFELDLRVVQTTAAVTSMR"
                     /locus_tag="JQS43_RS22025_lanthipeptide"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       9845..9919
                     /prepeptide="core"
                     /locus_tag="JQS43_RS22025_lanthipeptide"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="-5.40"
                     /molecular_weight="2122.2"
                     /monoisotopic_mass="2120.8"
                     /core_sequence="CDTSDNCGATCGTSACNSGSLDPS"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MPPVLMLDEADTSTPIPDEEFELDLRVVQTTAAVTSMR"
                     /leader_location="[9730:9844](+)"
                     /alternative_weights="2140.2"
                     /alternative_weights="2158.2"
                     /alternative_weights="2176.2"
                     /alternative_weights="2194.3"
     gene            10001..13069
                     /locus_tag="JQS43_RS22030"
                     /old_locus_tag="JQS43_21950"
     CDS             10001..13069
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155: Lantibiotic dehydratase domain protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018789021.1"
                     /locus_tag="JQS43_RS22030"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21950"
                     /product="lantibiotic dehydratase"
                     /protein_id="WP_239676276.1"
                     /sec_met_domain="Lant_dehydr_N (E-value: 2.1e-201,
                     bitscore: 668.7, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 3.4e-16,
                     bitscore: 58.0, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATTPVRYQHQNVMIVRASTDPGDLDRLGIDLDDPAAVATEGRVW
                     LTKLWSRTDVREALSLASPTLAARVEQLLDRDPAVTASADLRRAVLSAAGYLMRWQRRA
                     TPFGLFAGVTAAAVGPAAASVGQDHRAVVRVDADWLTALVDQLEQHPPLLQRLTVVADT
                     AGMVRDGRFVVAGRADASAGTPGPLREVSVRYTRPVQAVLAAAAAPVRVESLVPRVAAA
                     FPTTPPAKVAALVDALIAQRILLTSLRAPMTAVDGLAHLVEVLRAVDAAELADIAPMLS
                     QLEKIREQLADHNTCPDQRQAAAFRASAAAHMDSLATTAGHVLAADVRLGSHITLPENV
                     VEEAQQAASVLLRLTTKPFGTQAWLDYHARFRVRYGPGALVPVRDLVAGSGLGYPAGYL
                     GGPRTRPTWRALTERDAALLAMIQQAAADQADEIDLSDADVDTLTVGEHTDLVAPQRVE
                     LGVVLDAASTGEIDRGRFRLWVTAVPRAYTSMAGRFTYLLDPTDRRRLAATYAAPGGDD
                     VVAVQLSYPPRRPHNENVVRIPRLLPDVVCLSEHHDGDTIRLDDLAVTADAEQMYLIQS
                     STGRRVVPRIPHALDTSVQSPPLARFLAEVADARSAVFGPFDFGAARTLPHTPRIRYRR
                     TVLAAARWILTAADVATDAGWQAGLESWRRRWRVPARVVLRDGELRLPLELDQRLDRTL
                     LRGRLEKSGRLELQEDVPSQAPGWIGRPAELLIPMTTAAPQPRPVPTTAPPGPVHRPGS
                     SRLLHARLTGDPAHFDDLLVCHLPALVDELSRLGLRRWWAHRHRDHPDGDQHLAIVVDL
                     TTPDRYAPTAAKVATFAAGLHQRGLPADIALVPYAQQPGRYGEGPALAAAELVFAADTQ
                     AAIAQIATARACGVPAQALAAASMAQLAAAFAPDPATGYRALLACLPQQTGPLDRSTAA
                     LARHLSDPAGGFSRLRGLPGGQRIVEAWHERDAALAAYHHNLTGQRDPSTVLRSLLHGH
                     HRRALDLAPETEKTTGRLARAAALRRLAPSAAQ"
     aSDomain        10472..10753
                     /aSDomain="Lanthipeptide_LanB_RRE"
                     /aSTool="RREfinder"
                     /database="RREFam.hmm"
                     /description="RRE-containing LanB protein in a class I
                     lanthipeptide cluster"
                     /detection="hmmscan"
                     /domain_id="rrefinder_JQS43_RS22030_Lanthipeptide_LanB_RRE.
                     1"
                     /evalue="1.80E-18"
                     /identifier="RREFam001.1"
                     /label="JQS43_RS22030"
                     /locus_tag="JQS43_RS22030"
                     /protein_end="251"
                     /protein_start="157"
                     /score="58.0"
                     /tool="antismash"
                     /translation="TVVADTAGMVRDGRFVVAGRADASAGTPGPLREVSVRYTRPVQAV
                     LAAAAAPVRVESLVPRVAAAFPTTPPAKVAALVDALIAQRILLTSLRAP"
     gene            13165..14226
                     /locus_tag="JQS43_RS22035"
                     /old_locus_tag="JQS43_21955"
     CDS             13165..14226
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140: Lanthionine synthetase C family protein"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_018724314.1"
                     /locus_tag="JQS43_RS22035"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21955"
                     /product="lanthionine synthetase C family protein"
                     /protein_id="WP_239676277.1"
                     /sec_met_domain="LANC_like (E-value: 3.6e-37, bitscore:
                     126.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGTGGWATAHEHIRQVTAGPVDAAAHTGLFYGAPTVAFLLHTAG
                     ADGKPRYRQAAATLDRHILHLTRQRVADANERIDHGENTRFSEYDLLYGLTGIGALLLR
                     HLPGSDTLADLLHYLVRLTGPHPADERLPGWWVAHDPDPLLPTPGGHANLGMAHGAAGL
                     LALLALATRSGVLVDGQREAIDRLLAWFDTWRQDGPEGPWWPQWLTRDELRTGRAAQPG
                     PGRPSWCYGTPGIARALQLAAIATGDQLRQRAAEDALAGSISAPRLQLITEPGLCHGAA
                     GLYQTISRAAHDAANPTLRRQLPALADRLAQHSSSAHGDGLLTGSAGLTLALETARNRQ
                     PPRSGWDACLLIS"
     misc_feature    13990..13992
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            14208..15182
                     /locus_tag="JQS43_RS22040"
                     /old_locus_tag="JQS43_21960"
     CDS             14208..15182
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_kind="biosynthetic"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_013289219.1"
                     /locus_tag="JQS43_RS22040"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21960"
                     /product="thiopeptide-type bacteriocin biosynthesis
                     protein"
                     /protein_id="WP_239676278.1"
                     /sec_met_domain="Lant_dehydr_C (E-value: 9.3e-36, bitscore:
                     122.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTDQLIPALPDDLARGVLAVLAGSDPSTTAADLGITSDDLTDAV
                     QLYQAAGLAALEQRAEHEWYDLRLRFPDWHTAEAAAANRLAPALDQLLQEGETAGWWFL
                     RKHPFWRLRLHHADTTAVARLLEQLTRQGILTGWHQTIYEPETAAFGGPAAIDAVHALS
                     CADSRGLLNYVRQPSPALGRREMSMLLFTAFQHAAGLDWFEQGDVFDRVARLRPTPTGS
                     DDQRVETLSADLSSILTANANAHTPLFAPGGPAAFASRWRTAFIQTGHMLGEAAARGRL
                     DRGLRAVIAQIAIFHWNRLGLPARTQGILAHSAATALLGTRLG"
     misc_feature    14748..14750
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15341..16519
                     /gene="fxlM"
                     /locus_tag="JQS43_RS22045"
                     /old_locus_tag="JQS43_21965"
     CDS             15341..16519
                     /GO_function="GO:0016740 - transferase activity [Evidence
                     IEA]"
                     /codon_start=1
                     /gene="fxlM"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PCMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089: methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:TIGR04364.1"
                     /locus_tag="JQS43_RS22045"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21965"
                     /product="methyltransferase, FxLD system"
                     /protein_id="WP_275581098.1"
                     /sec_met_domain="PCMT (E-value: 6.6e-44, bitscore: 148.4,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRALVERISARRQLSDAVAAAMYKVPRHVFVPTASLEEAYANDT
                     VVTRRDDTGIATSSASAPWLVGQMLDQLQLQPGMRVLEIGAGTGYNAALIAELVGPTGH
                     VTAVEITPDVAADARKALATIGATNVEIVCGDGEYGHPQAAAHDRIISTAGVWEIPDAW
                     AEQLSPEGVLVAPLRMRGLTRSVAMTREAGVWRSHSTVTCGFMPIRGKGEMPERNIRPA
                     EDLFVRFDDGQDADALALAQAAASPGRVDWSGVLIDRSLELLDFYLAELDGFCRVLASP
                     SITERGLAEPVNDWGSMGAATDEALGYLTKRTCLDNPYLYELGVCAYGPRAAAMLADLT
                     ERVHRWDRDRESITGVRIEIHPPGQGEMADALMIADKRRSRVVVRPVRQESK"
     gene            complement(16937..17206)
                     /locus_tag="JQS43_RS22050"
                     /old_locus_tag="JQS43_21970"
     CDS             complement(16937..17206)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22050"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21970"
                     /product="hypothetical protein"
                     /protein_id="WP_239676279.1"
                     /transl_table=11
                     /translation="MSLPGSGHDLQAPQRRTRWLLHCTIAAAILLVAVVVAVGVLWDRS
                     GVDCESWSDEFIGALEDGTLSDGTFEASEVCREQMRRDLDRLSD"
     gene            complement(17301..18011)
                     /locus_tag="JQS43_RS22055"
                     /old_locus_tag="JQS43_21975"
     CDS             complement(17301..18011)
                     /codon_start=1
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_019033894.1"
                     /locus_tag="JQS43_RS22055"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21975"
                     /product="creatininase family protein"
                     /protein_id="WP_239676280.1"
                     /transl_table=11
                     /translation="MDVITTATSPEVGALGASVALLPVGSHEQHGDHLPLATDTIIASS
                     IAAVLAERYRLLLLPPLTISCSHEHWAWPGTVSIRATTLATVIKDVAESLHASGIDRLV
                     IVNGHGGNYVLSNVVQEATVAGPVMALYPGRDDWNRARVDAGLETTSHDDMHAGELETS
                     LLLHLHPTLVRGSYADADYDAPHRPHLLTLGMQAYTASGVVGRPSAASPAKGRALLESL
                     IASFRSSLRLLDPR"
     gene            complement(18014..19399)
                     /locus_tag="JQS43_RS22060"
                     /old_locus_tag="JQS43_21980"
     CDS             complement(18014..19399)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF024949.4"
                     /locus_tag="JQS43_RS22060"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21980"
                     /product="helix-turn-helix transcriptional regulator"
                     /protein_id="WP_338037138.1"
                     /transl_table=11
                     /translation="MPQSPPRRLSGTPRAPPPNKRPTCRRRWAWTLCGIATLVGSPVGW
                     VARQPTISICCGSDRRIRPATQPSTWELPTMPRRTPPDPRFGQRMRTLREQHALSFREL
                     GRLTLASKSKLHKIETGMVAADAETATRLDDALGAGGELTAMVRPAAVQLPQDTVTPTP
                     AVDLAAHWRDMLRVLTAADNALGGHGLLNLVSTELQLIDSQRETAARPARTDLTVVAAR
                     WREFGSWICDNEGHDQQAGRWLEAAGSMAREAGDVTLTAYVGMRRAQRAVEKGQVGAAE
                     ALVQPVLGAGGLPPRVRALAAVRLAQAHAHHGDATGTRRSIGTAFRLVDQSAAEDPQTA
                     SLVSHCTSVYVRAYEACCRLLLGEPAAAIHDFETVLADWPHHQRLDEGFFRAHFAVALH
                     LAGDVDAARDHAAAARELGLQTGSQRTLSLVTEVAADRTATVPVGGHPATRVVAGSGEH
                     GRV"
     misc_feature    complement(19286..19288)
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    19399..19413
                     /note="TFBS match to CelR, Cellobiose uptake repressor,
                     confidence: weak, score: 23.18"
                     /tool="antismash"
     gene            19606..19779
                     /locus_tag="JQS43_RS22065"
                     /old_locus_tag="JQS43_21985"
     CDS             19606..19779
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22065"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21985"
                     /product="hypothetical protein"
                     /protein_id="WP_239676282.1"
                     /transl_table=11
                     /translation="MTIAPRRLGTGKDEVICRRSRGYRPPQPTRAPSWWEQVLEDLSTP
                     VWLRRLRRRLRD"
     gene            20027..20566
                     /locus_tag="JQS43_RS22070"
                     /old_locus_tag="JQS43_21990"
     CDS             20027..20566
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22070"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_21990"
                     /product="hypothetical protein"
                     /protein_id="WP_239676283.1"
                     /transl_table=11
                     /translation="MVYDLARVAELLHQRNTIDEQITQIIKRPVASGHLGEWIAAWVFD
                     IELETSASTAAVDGRFLTGKLQGRTVNIKWYLKREGLLDMTTADVPDYYLVMTGPAGPA
                     ASSRGGSRLWRIDNVYLFDARQLLSDQLARGVKVGVASSVPQSWWKAAEIYPTANDAVL
                     AVSREQAAMLALFRPR"
     misc_feature    20057..20059
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     misc_feature    20549..20551
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            complement(20700..21335)
                     /locus_tag="JQS43_RS22075"
                     /old_locus_tag="JQS43_21995"
     CDS             complement(20700..21335)
                     /codon_start=1
                     /inference="COORDINATES: protein motif:HMM:NF039405.3"
                     /locus_tag="JQS43_RS22075"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_21995"
                     /product="DUF6308 family protein"
                     /protein_id="WP_239676284.1"
                     /transl_table=11
                     /translation="MKDLLTYYHVGEPRSATPPLFTGGWFDQLGGGGDRPDTANRITAE
                     DLMAVEMLGVQYPAKVALWLLVGDLGVQLSALLAEVPRQVDLASSGNLQPDPVADGGPA
                     DRAWQLLINQPNVRWVKASKLLARKRPRLLPIYDSVVAGGAGYRVGCYWTCLRRVLQQD
                     DSALHRQLVQLKGDAGLPDPVSPIRILDVAVWMRHRQGADDFRRRNTA"
     gene            21966..22949
                     /locus_tag="JQS43_RS22080"
                     /old_locus_tag="JQS43_22000"
     CDS             21966..22949
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22080"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_22000"
                     /product="hypothetical protein"
                     /protein_id="WP_239676285.1"
                     /transl_table=11
                     /translation="MIVGLGGVAVAVESDCTLVHQLIAEFYPVESGPSEPMWTIVAYAQ
                     APPRGVAVNRFGVGYQPDLAGRSLILWATRETDLAITTRKCVREIFLDACERAGYGMLH
                     ASAVYHDDQAIVFAADKRGGKTTLALRAVLDHGWRWLSNDHLIVWRGEAGLVATSLPTP
                     IPLKVGTYVDLIDRLPPPWDSNGINAEMWRAATPVARYASDAAVYYTFGRLGQANPVLV
                     ELAGRRLTVVFPSYAGPGQREGVVEMVPAQAAASELAGHGRTDWIEDQRLHQRHLPFPH
                     RDVAAFGRDSVVLAAQVAAAGAEVVRFTHRGDPSPLLVNVAEAVPR"
     gene            22946..23908
                     /locus_tag="JQS43_RS22085"
                     /old_locus_tag="JQS43_22005"
     CDS             22946..23908
                     /EC_number="2.4.-.-"
                     /GO_function="GO:0016757 - glycosyltransferase activity
                     [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /inference="COORDINATES: protein motif:HMM:NF025025.4"
                     /locus_tag="JQS43_RS22085"
                     /note="Derived by automated computational analysis using
                     gene prediction method: Protein Homology."
                     /old_locus_tag="JQS43_22005"
                     /product="glycosyltransferase family 2 protein"
                     /protein_id="WP_239676286.1"
                     /sec_met_domain="Glycos_transf_2 (E-value: 4.3e-22,
                     bitscore: 77.0, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRRPLVSVVVCTYARPEPLRAALASICVQGVDGVEAVVVNDGGP
                     DVAGVVAEFGDRLPVRLITLPTNKGLTAARRSGIGAARGRFVAFLDDDDLWLPDHLSVA
                     LDGLDSGLDLVYTTCLVADRVHHLGSEEPVSARYRFDYPFDAALFDVTNMIPVTSVVAR
                     RFDPAMLHRHDGVQDDWAMWLDLVRGAGWRLLHLPAATTVYHRIPQAASMTGQAASTLA
                     GLRRFAAGHRRIHQRWPVPNGSRAGQARRLPFWMYRLVEQRHSAGHGVSHYYYERCLPL
                     VAAAVTGRMTINAAVDAMDVAVAPDAVEEREQAAWRVLA"
     gene            23890..24240
                     /locus_tag="JQS43_RS22090"
                     /old_locus_tag="JQS43_22010"
     CDS             23890..24240
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22090"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_22010"
                     /product="hypothetical protein"
                     /protein_id="WP_239676287.1"
                     /transl_table=11
                     /translation="MASAGVIDPPLRARIRAALPDAQVDTVLHDNGKALVLSGTVAGQR
                     AVVKVLVDPDPFWAGKFPAEITIYRAFEVAPPPAPVPKLQHQPRHVGPLRTAVLRPFAG
                     PTARGSPAHRRR"
     gene            complement(<24200..>24769)
                     /locus_tag="JQS43_RS22095"
                     /old_locus_tag="JQS43_22015"
                     /pseudo=""
     CDS             complement(<24200..24769)
                     /GO_function="GO:0003677 - DNA binding [Evidence IEA]"
                     /GO_function="GO:0004803 - transposase activity [Evidence
                     IEA]"
                     /GO_process="GO:0006313 - DNA transposition [Evidence IEA]"
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1130: transposase"
                     /gene_kind="other"
                     /inference="COORDINATES: similar to AA
                     sequence:RefSeq:WP_011689697.1"
                     /locus_tag="JQS43_RS22095"
                     /note="incomplete; partial in the middle of a contig;
                     missing N-terminus and C-terminus; Derived by automated
                     computational analysis using gene prediction method:
                     Protein Homology."
                     /old_locus_tag="JQS43_22015"
                     /product="transposase"
                     /pseudo=""
                     /transl_table=11
                     /translation="MAQGVSLLGRDGLLQQLTKRFLEATLAAEMDEHLGYGKHEPAGRD
                     GANSRNGCRSKTLLTEVGPVRVGVPRDRDASFTPQIVAKRQRRMGGIDDLVISLTAKGL
                     TTGEVCAHLAEVYGATVSRDHISTITDRVLGIMGEWQNRPLDPIYPVIFIDCIHVKIRD
                     GQVANRPVYVALAVTADGGREILGLWA"
     gene            complement(24718..24912)
                     /locus_tag="JQS43_RS22100"
                     /old_locus_tag="JQS43_22020"
     CDS             complement(24718..24912)
                     /codon_start=1
                     /inference="COORDINATES: ab initio prediction:GeneMarkS-2+"
                     /locus_tag="JQS43_RS22100"
                     /note="Derived by automated computational analysis using
                     gene prediction method: GeneMarkS-2+."
                     /old_locus_tag="JQS43_22020"
                     /product="hypothetical protein"
                     /protein_id="WP_239676288.1"
                     /transl_table=11
                     /translation="MTTKTRTAMTAGEGHGLAWAPAVLHQPEGPKGEAAAAALDPQLVA
                     RLAGRRACRCWAATGCCSS"
ORIGIN
        1 gaccaccacc gccagcgtct ccaggcacgc ggccagcagc accaccgccg ccacccgcgc
       61 caccatgggc agaccgtccg ggaacggcaa gtgcgtcagc ccgacccaaa cctgcccgat
      121 agcggccccg gccaccgcca ggccgtagta cggggccgcc agacgctcgg cgctgatgct
      181 cacccggaac cggcgaggcg gccggctatc gcgggtcgcc gcagcggtcg ccctcgccac
      241 cgccgcgtca taggcgtcct gcgacggcag accccggtct atcacctgct gcaacaccgc
      301 aggttccata cgcccactca tgcgatcacc accgcggcaa caaacagcca gccgatgtgc
      361 caggactgat cgagcgcgta cgccccggta ccaagcgacg ggttgtcatc gcgaccgggt
      421 cgcggaaccc ccagcaggta gaaccgggcc gacccggtcg cctcagccaa ccgccgcagc
      481 ggcgtacgcc ggtcggcgat gtagtgggtc actgccgaga tcgccagccc tgccgcgacc
      541 cgccacgggt ccaacgtcag cccggtaccc agcaccagca ccagcagcgc caccaccccg
      601 gtagcggtgt aggacaccac gtgccccagg caggcgaccc gaccacgcca ccccggcaaa
      661 cccttgtgat ctgcctggtg ctgagtctga acgaagtggt cacccaccat gtgagccgca
      721 tacaaggcag cgaataccgc cccgaccacc gcggctgcct catacccggc gctcatcggg
      781 ccacctccgc acgcccggcc gccgtcagcg ccgccgccac cgcatcaaca gcccgcgaag
      841 gcaatgcaac ggtgatgtgc tcaccgctgc ccagctccac cgtcagcccg gtatgaccgg
      901 tacggccgat gtcctccgtg acgaccaccc gcacccgcgg cgagacctcg atggtggtcc
      961 gccagccgcc ggtctccagc tcgaccacct ctggcgacgg gccgcggtca cccgggtccg
     1021 cgccggagaa gcgggcggcc acctcggcca cctgctccgg ggtgagctgg tcggcacggc
     1081 gccaggagcg cagcagggtg gcggcgctgt ccggggcaag gtcgaccccc cacgcggaca
     1141 gggccttgat cgcgtccgcg acgatcgggc gctcggtgtc gccctcctcg gccgccacct
     1201 cggcggcgta ttccgacacg taatccgccc actcggcggc ggcatcctca acgaccgccg
     1261 tcttctcggc atcgccccgg tagtcgtact cagacggtgc cgggccagcc gctgaggcca
     1321 gctcgggccg cacagcggcc gaggtgacct cgtcgtatcg tggattcacg atcaggagcc
     1381 tccaaacttc ttgatccagg ccccggacgg cgttgcagtc gccaaccggg gccaccttca
     1441 cttcaggccg catcggcaag accagccgaa acactcggac ggcggcggaa ctcgaccacc
     1501 acccctgacc gcggctgccg cagtcgacgc cggatctccc acgcgctgac tccccgcccc
     1561 gccagcacgc gcgccgcttc agcccgctcg gccgccgtca gctccaccgg ctcgccccgg
     1621 cacgccagcc gaaccgccac ctcatcgacg tggtccgggt ccggcaccag ctcgcgtggc
     1681 agcccgtgct ccaccacgac ccgctcgtca tcacgaatcg ccagctccca acacgccccg
     1741 caggcgaccc cgcccaccag cagcggcacc ggcacaccat gccggcagtg acgcgaagcc
     1801 accaccgcca gcgggtgcga ctgacccaga tgtccctgtg tcaccacgta tctcctttcg
     1861 gtggtctgtt gcgatgcatg cgaacctaac agttggctgg tttgccagtc aactgttagg
     1921 tacaactttt cgctgacgtg ggccgtgcag cagtggtgac ctcgggagac acagccaact
     1981 gttaggcgct ggtatcgtcg gcacgatccg tcgccacgct cagcaggccg ctcgggaggg
     2041 tgtccatgtc gtcgcctcga ccaccgctcg aaccatcgga gtcacgcacc cgccaggtag
     2101 cgcgcaacat ccgaaccgac atcgaggccg gggtactccg tcacggtgac gtgctgccat
     2161 ccacgcgcga gctggccacc gagtggggcg tcagcccgtt cacgatcagc gaggcgatga
     2221 agcttctggc cgcggatggg ctggtcctca gccgttcacg agccaagcgg gtagtcaacg
     2281 cacccgccca ggcgcgccgc accgagatca gaggctcgac cccgcacgtc atcgtgatcg
     2341 gcggttacgc cggtagcggc aagacagagc ttggccggat cctggtacgg gagacaggct
     2401 ggccgctgct cgacaaggac acactcaccc ggccggtggt cgagacagcc ctagagtcag
     2461 tcggacgatc cccgcacgat cgagactccg actactacat gaaagagatc aggccgcgtg
     2521 agtacgaagc actcgccgcc gccaccaaag agaacgtcga gtgcggcaat agcgcaatcg
     2581 tcacggcacc gttcatccgg gagttcagcg acgacgcttg ggtgaagcga atccaggccg
     2641 ttcatagcgc gatgaacgca actaccacct ttgtctgggt ctactgcgac ccagagacaa
     2701 tgcatacata cctacggcgt cgaggcgccg ctagggactc cggcaagctg tcggactggc
     2761 caggctattt gtcggtgatc gacgtcgact tcaggccgtc agttccgtac cacctcatcg
     2821 acaattcgga ggctgcggca ccactccatg accaggcccg ggagctagtt cgaacagtca
     2881 tggccgacaa catcggctct accaaatgac cgcggaggcg ctgccattca gacagcaacg
     2941 agtgatggtc atccttcgtg gcctgccatc acccactgcg gcggtggcgg cagcgagccg
     3001 agcgtgggat tcaggcgtcg agctggtcga ggtcccggtc gaacggcctg agctggtctc
     3061 gtcgctcgcg gcagtggtgg cagctggagc ggagcgcggc aagggtgtag gagctggcac
     3121 ggtgataacc ggcgaccagg tccgggcggc ggccgccgct ggtgcccagt acacggtggc
     3181 gcctggtctt gaccttgcgg taatggccgc gagtcgagcg gccggtatac cgcacctgcc
     3241 gggcgcagcc accgccaccg aggttcagca cgctaaggcc gccggctgcg attgggtcaa
     3301 ggtcttcccg gccggaaccc tcgggactgc ctggttccgc gcgatgcaag gcccgttcca
     3361 caccatgaat ttcctagcta cgggcggggt atcgctcgcc gccgcgcccg actaccttgc
     3421 cgctggcgtc cgggtggtgg ccttcggcgc tgccgcaacc gatgcagaac accggcaaca
     3481 cctccgggac ctggtcacgg caccaatgag agcagctgtc aacgggtgtc agcgcgcccg
     3541 ttgacgctcc gtctggcctc ctgaacagcg caaacaccag actgtcaacg tgtcaacgct
     3601 gtctcccgag agccgcaagg ctcctacccg gcccgctccg gctgagactg cgtttcctcc
     3661 ttcttgccga tactctcgtc caagtcgttg atgaacatct tcaaaatctg gtgatcatct
     3721 agagatttgt ctttgtgccc caaatctcgg cgcatagcaa gaatcaattt ttcccactcg
     3781 aacagtaact gcttacctct gcccttgtct ccagccgatc cttgcaccgt cagctgacga
     3841 aatgctatcc actgattcaa gacttgagct gaagcccacg gcatcgcttt agctgagaag
     3901 tttgcgaagt actccactac agcactgtca tcgaccttct ctacacgctt ctccttgggt
     3961 atattgagct gcattatctt caaccattct cgaatgaatt cctcatacaa cttagcccat
     4021 tgggtacgct gctcggcctc aattgccttc ttccgctcaa agacccgacc tcccacaacc
     4081 gtgagagttg caacgatcac ggtggcactt gcccccatca tggctgccac tacagtcgga
     4141 tcagccctga cgaagaatct taaagcacta aacagaaagg cgcctatcag cagcagcagg
     4201 gctaccacga tcagaactgc tacagtcaac tgcgccttcg acgtctcttt cttcgctttc
     4261 atcagacaat cgtaggtctg atgcgaaggc tccaccatgt ccaaactgtc gacttctcga
     4321 cagtggatgg ctaaggcgca ggccggaagc taggaccctg accggctacc ctcgtcacgg
     4381 cactaccgct gccgccgacc aacattcatg aaatgatcta gaatgcgccc gagtcacggc
     4441 acaagttttc ccagctcatc gtgggtgctt gacggcgaaa ctcggccgtc tgtaaaaccg
     4501 tcgcgaaagc tacactggtt cgaatccagt acccgccacc accagcgaaa gcgcccgacg
     4561 accagcacga acaccaagac cctctagcgg cgtatgtccg gccgtcggtc cggttcagtc
     4621 ccgccatatc cggccctcta cggccatcca cggacacata gcggacagaa tgatcatggt
     4681 ccccggctga catcggaccg cgggtccacc gatgccaggg gccgcggtgg tcatggagag
     4741 cgcccacgac atagcgatct tgccgcggtt ggccggcagc gaaagggctt acctccacct
     4801 ttccctagcg aggctggccc gtcgtgaacc gagtctccta ccgagtgccc gcctgtcgca
     4861 cgtgcgaacc cgcgcccacc tggcggctgc ggctgcccgc cggttcatcc cagcccagtc
     4921 cacatcacac atatcggccg ggcagacccc ctagacccga ctcgatctcg gcaacggccc
     4981 tcgcccggga acagagccga tgatgcacca gcccatcctc cacccggaag taggccggcc
     5041 cacccggacg cggcccgtcc gcatacggca gcgccaccgc ggcaagatcc atccccgcac
     5101 tggggttgtc acgggccgcc tccttgtcac caacccacgg gcgtgggcga gctggtaggc
     5161 tcaaggccgg tcgggtgcgc atcgaggcgg ccacgacccg cggcaaggcc gagtgccccc
     5221 gccaggatca tgctgccggc acagcgccgg ctccggcggc agcgtccacg cgatgaaccg
     5281 gtcgtagagc tgcgacaccg acaggtgcgg taggtcccgc accgcctgct ccagcagctc
     5341 gaacgccaac tcgccgagtc tgcgtccata cccgtaccgg atcagcagcc gtcgacgggc
     5401 cgccgcgcat ggccacgggt caccacaccg gcactgccac agccgatcgc caccgcgcag
     5461 gcggggcttg tgcttgccga ctccccgcag gtcccaccgc cgttgcgtga tcatcacggc
     5521 cgcccccgct cactgacaga cagcgctagc accgcgcggg ctgccagttg cgccccgtgc
     5581 tcttcccaca gtgaataggt gcgggtcatg tgggccacca gctccgccgg gcctgatcca
     5641 tcagccagcc gccggcggca cagcgctacc tgcgcctcca ccaccccatc gccccgctca
     5701 aactgccgtt gcgactcgag cagatcctcc tcatcccact cccggggctg cccggccatc
     5761 atcgctaccg cgtcgctcag cagcgccgca agcatctcgg catcccggcc ggccagcgaa
     5821 cgctctaccg cgccctggcc gctgtggcgg gccagccgca ccaacgcggc cacctggtgc
     5881 ccacgccgtt ccatgacgcc gcccaatgcg gccgggccgg tggtcttaag ggcagggacg
     5941 ctaccccccg gactaggcat tgctttcctc ctgctcaaac tcccgccacg ccgccgcgag
     6001 gtcggcgcgc aggcaatcct tggcccctaa gtgggcctgc gctaggttca gcacccgctg
     6061 cgcctcgcgc cgatggccct cggcagccag ccctcgggcc gctgccagca acacccggca
     6121 gcagcggtcg gcgtcgccgg cctcgaccgc ggcctgcaac gccaccagca acaacattcg
     6181 cggctgcccg gaccccgccc cggccgccac ctccgccaca gtcgcctgcc gcggctggtc
     6241 tggctgcgtc ccgactcacg cccgcgttcg aggacgtctc cggtcctgcc gaccccgggg
     6301 attggatgaa cgtcaccgtc aggtagcggt cccggcgtct ggccggggtc tgccgccggc
     6361 ggctcttgtc gacgtcgacg ctgtagcact gtgtcacctg ccttgtcgcc ttaggaggta
     6421 gtcggacagc gcagcggcga gattcccgac tccgccacgc cgcaccgagc acaacgctcc
     6481 ctcccccaga aggtgcgtcg aaccaatccg ctgtgccttg tgggcagcga gcggctgtca
     6541 ctgacagtca gcttcgtccc catcaccgat cgacggaagg ccttgcctgt ccatcccgtg
     6601 tccattcttg atggtacggg tgtccaacac cgtcaccaga gctgctcgcc taggctcgtg
     6661 gcatgacgga tctgtggaac gtgtcgacag cagtggaaga tcggcaggcg gcggaggttc
     6721 ttgccgaatc agcgctcatg gcaaagctcg ccgccagcgc tcagcttgtc gggccggttg
     6781 gctcgatgtt ctggcaccac ggcgagttcg gaagcgcgca ggagtaccag gtgatcttca
     6841 ggactaccgc ttcttgctac caagcgctcc aacagcacct gatcgacaac cacccttgga
     6901 agaatccgga ggtcaccgcc gtgtccctgg ctgcagcgtc accgcagtac gcccggtggg
     6961 tggagcagac agttgccgaa gattgaacac ttgctcagcc ctcgtgcgca ggtcggccac
     7021 agcaggctgt accggttcca tgcgaccgat gaggttccta atccgctcgt gtggccgtac
     7081 cgaacccacg cctgcgcaca gatccatggc cttggacgca accgcacacg cctgctcgat
     7141 ctcgttagcc tccaggtagg cgtcggcgag gaacgacagg tacaacccct tgtcacgtcc
     7201 atgggtgtcg tcgtagcaat ccagggcgtc ctccagtgct ttgatcgccc gtagcggccg
     7261 acgcagcgct gcccagcaac gcccggtcat gatgtcgtgt tccaggccgt cgacccagta
     7321 cacccagtcc ggctcggccg cctgagcgga gacggtgagg gcgtcagctg cgatgtcaag
     7381 gtgccgctgg gtctgcgagg cgtcgccgat gttggcgtgc gcccatgccc gcctgcagtg
     7441 caacaacgtc ctcactttcg gagggctacc gcgctcggcc cactcacatg ccgcagtaag
     7501 gtcctcgatc ggaggctcgc ctaccgtgag cctctgatac cccaggaacg cgaacgcgtt
     7561 cccggtaagc gaggggtcgc ccgcctcctg ggcagcttga aggctcagct cgtacatgtg
     7621 ccgcgcctgt ggctgccagc cagcgtcgaa ggcagcccat cccgcgagct gggcttgctc
     7681 ggatagcaaa gccaacagct gcctgcccgt ggcttcggga tagcttccct cgtgcagcag
     7741 gagtgcggtg gcctcgactt cctcagcgaa cagttcgtag gtgtcggcgc cgccaaagta
     7801 gtcgtcaaga cgccgcaggc gtgcggtgtt catcagcagc tgccgaacta ggtttccgcc
     7861 cagctggcga cccgccttca aatgatccat caacggtgcc agggccaccg ctgatgctgc
     7921 gacgcccagg aactcccgcc gcggcaacaa cggtgcgggc tgcccttcct gccctagctg
     7981 ggcgagtcta gctagatcgc cacaggcgtt gagggcgttg tcgatcagct gggcggtttc
     8041 cgcgtcaggg acgacccgcc cggtctcgat ctggtagagc ttcgacttgc tggccagtgt
     8101 gagccgagca agatcacgaa aggagatgtt gcgctgcttc cgtagctcgc gcatatggct
     8161 gccgaagcca gagtcgacag tagagcggcg tggcatcgta acccccaggt ggaggactgg
     8221 gaaggctgcc ggcctccaca ccggcggccg aaacagatcc taccggccac ccgtccacaa
     8281 ccgccagcgg ttcaacggcg tccacccagc gatggacagc cgtcgcgatg gtggacaacg
     8341 ggtggacagc tcgtccgttg accccagtca tccaacgtcc ataggctcta ctgcacacgg
     8401 aagccgactc gctcccgtgt gggacagcca agcgggttag gggtgttgtg tgaccgacga
     8461 caagacagca agatcgcgag acactctcac ggaccgcctt aaggccgatg acatgatccg
     8521 ctcggaggcg gtcgaagcgg cgtttcgacg ggttccacgg cacctgttcg tccccgctgg
     8581 cacatcgatc gaggaggcct acagcgccga tgctgcccca ccaaccaaaa aggatgtcga
     8641 aggccagatc atctcgtcgg tgagtgcacc gttcttgcag gcgcagatgc tggagcaggc
     8701 gcagctgcat cccggcgcga gcgtgctgga gatcggctcc ggaggctaca acgccgcgct
     8761 gatcgctgag gttgtcggcc cggctggtcg agtggtcagc gtcgacatcg acccggacgt
     8821 caccgcctgg gcgcgcgaag ccctcgatgc cagcggctac ggcaaccgcg tcgagacggt
     8881 gtgcgctgat gctgagcacg gtctagccgg atcgtcggtt tttgatgcga tcattgtcac
     8941 cgtgggggcg tgggacatcc ccccggcctg gctgacgcaa ctggatcatg acgggacgct
     9001 ttcggtgccg ctgcgaatga acggggtcac ccgctcgata gccttcgcca ggcaggccga
     9061 tcatctggcg agcacctcgg cggaggtttg cgggttcgtg cctatgcagg gtctgggcga
     9121 acggcgcgag cgggtgctgc agcttcccga cggacacggg cggtacgtga ggctgcgctt
     9181 cgacaccggc gcgccggagg atcccaattt gctggacggt gtactcgccg acatgaaggt
     9241 ccgggtgtgg tccggggtgg agtttccgaa cggcgtctcg ttcgctgacc tgcacctgtg
     9301 gaatgcgtgt ttccttcccg gtttctgcaa ggtggctgct gatgagggca cagaactggc
     9361 ccaggaccgc aagagctggt ttccgttcgg gtgcgttttc atcgactcgt tcgcttacct
     9421 cgcggtgcgc ccggccatgg acggagccgg gattgagttc ggggccggcg cctacggccc
     9481 caacggcgag caggccgctg cggcgatggt ggagcagatt caggcgtggg accggcgggc
     9541 acgccgcggt ccagtgccca cgttcgggtt ctggcccgac ggcagcgacc ggagccacat
     9601 cccggatcac gtggcactgc tggagaagca ccatggcctg gtcacagtct cgtggccgcg
     9661 ggctagccgg ccgtaggccg aaacgtccag aagaagaaac aacccctacc ttctgtaagg
     9721 agtcgtattc atgccaccag tgttgatgct tgacgaggcc gacacctcca cgccgatccc
     9781 ggatgaagag ttcgagctag acctgcgggt ggtacaaaca accgccgcgg tgacctcgat
     9841 gaggtgcgac accagcgaca actgcggcgc cacctgcggc accagtgcgt gcaacagcgg
     9901 ctcgctcgac ccctcctaga tccggtgtcc ggccgggggt ccgcgcgatc ggcggacccc
     9961 cggcgtccct cttgccgcca ccccgttgag gagggtgacc gtggcgacca cccccgtgcg
    10021 ctaccagcac caaaacgtga tgattgtgcg cgccagcacc gacccgggtg acctggaccg
    10081 gctgggcatt gaccttgacg atccggccgc ggtggccacc gagggccggg tatggctgac
    10141 gaagctgtgg tcccgcaccg acgttcgcga ggcgctttcg ctggccagcc ccaccctcgc
    10201 ggcacgcgta gagcaactgc tcgaccgcga ccccgccgtg accgcctcag cggacctacg
    10261 ccgagcggtg ctgtcggcgg cgggctactt gatgcgctgg cagcggcgag cgacaccgtt
    10321 cgggttgttc gccggagtca ctgccgctgc ggtcgggccc gccgcagcga gcgtcggcca
    10381 ggaccatcgg gcggtggtgc gcgtcgacgc ggactggctc accgctttgg tcgaccaact
    10441 agagcagcac ccgccgctgc tgcagcggct aacggtggtg gccgacaccg cgggaatggt
    10501 ccgcgacggc cggttcgtcg tcgccggacg cgctgatgcc agcgcgggga cgccgggccc
    10561 gctgcgggaa gtgtccgtgc gctacacccg gccagtccag gcggtactgg ccgccgctgc
    10621 cgcgccggtg cgtgtggagt ccctggtgcc gcgggtcgca gccgcgttcc cgaccacacc
    10681 gccggccaag gtcgcggcgt tggtggatgc cctgatcgcc cagcgcattc tgctcacaag
    10741 cctgcgggcc cccatgacgg ccgttgatgg gctcgcgcac ctggtcgagg tgctgcgggc
    10801 cgtcgacgcc gccgaactgg ccgacatcgc cccgatgctg tcccagctag agaagatccg
    10861 cgaacagctt gccgaccaca acacctgccc ggaccaaagg caggctgccg cctttcgggc
    10921 ctcggccgcc gcgcacatgg acagcctcgc caccaccgcc gggcatgtcc tggccgccga
    10981 cgtgcgcctt ggcagccaca tcaccctgcc agaaaacgtg gtggaggagg cgcaacaggc
    11041 cgcctcggtg ctgcttcggt tgaccacgaa accgttcgga acccaagcgt ggctggacta
    11101 ccacgcccga ttccgcgtcc gctacggccc gggagccctc gttccggtac gggatctggt
    11161 ggccggctca gggctcggct acccagccgg ctatctgggt gggccacgga cccggccgac
    11221 gtggcgtgcg ctgaccgaac gcgacgcggc gctgctggcg atgatccagc aggccgccgc
    11281 cgaccaggcc gacgagattg atctcagcga cgccgacgtg gacacgctga ccgtcgggga
    11341 gcacaccgac ctggttgcgc cccagcgtgt ggagctcggc gtggtgctgg acgcggcatc
    11401 gaccggtgag atcgatcgtg gccggttccg gctgtgggtt acggctgtgc cgcgcgccta
    11461 caccagcatg gccggacggt tcacatacct gctcgatcca accgaccggc ggcggcttgc
    11521 cgccacttac gcggcaccag gaggggatga tgtggtggcg gtgcagctgt catacccacc
    11581 gcggcgaccc cacaacgaaa acgtcgtgcg gattccccga ctgctgcccg atgtcgtctg
    11641 cctgtccgaa catcacgacg gtgacacgat ccgcctggac gacctcgccg tgaccgccga
    11701 cgccgagcag atgtacttga ttcagagctc caccgggcga cgggtggtac cgcggatccc
    11761 gcacgcactg gacacctcgg tgcagagccc gccgctggcc aggttcctgg ccgaggtcgc
    11821 cgacgcacgc agcgccgtgt tcggcccatt cgacttcggt gcagcccgca ccctgccgca
    11881 caccccgcga atccgctacc ggcgtaccgt gctggccgcc gcccgctgga tcctcaccgc
    11941 cgccgacgtg gcaaccgatg ccggttggca ggccgggctg gagtcgtggc ggcgacggtg
    12001 gcgcgtgccg gcgcgggtgg tgttgcgcga cggggagctg cggctacccc ttgaactcga
    12061 ccagcgccta gaccgcacac tgctacgcgg gcggctggag aagtccgggc ggctggagct
    12121 gcaggaagac gttccctcgc aggcacctgg ctggattggc cggcctgccg aactgctgat
    12181 cccgatgacc accgccgccc cgcaaccccg gccggtaccg acaaccgcgc cgccagggcc
    12241 ggtgcatcga ccgggcagct cccgcctgct gcacgccagg ctcaccggcg acccggcaca
    12301 cttcgacgac ctgttggtct gccacctgcc cgcactcgtt gacgagctat ccagactcgg
    12361 attgcgtcgc tggtgggcgc accggcaccg cgaccacccc gacggcgacc aacacctcgc
    12421 catcgttgtc gacctcacta caccggaccg gtacgccccg acggccgcta aagtggctac
    12481 cttcgccgcc ggcctccacc agcggggcct gcccgccgac atcgcgctcg tgccgtatgc
    12541 gcagcagccg ggccgctacg gcgaagggcc cgccctagcc gccgctgaac tggtgttcgc
    12601 cgcggacacg caggcagcca tagcccagat cgctacggcg cgagcctgcg gcgttccggc
    12661 ccaggcgctc gccgcggcgt cgatggcgca gctcgccgcc gcgttcgcgc cggacccggc
    12721 caccggctac cgggcactgt tggcatgcct gccgcagcag accgggccgc tggaccggtc
    12781 cacagctgct ctcgcccgac acctttccga ccccgctggc ggattcagca ggctccgcgg
    12841 tctaccaggc gggcagcgga tagtcgaagc ctggcacgaa cgagacgcgg ccctcgccgc
    12901 ctaccaccac aacctgaccg gtcagcgcga tccatccacc gtgctgcgca gcctgctgca
    12961 cggacaccac cgccgagccc tcgacctcgc cccggagacc gagaagacga ccggccggct
    13021 cgcccgcgcg gccgccctgc gccgcctagc cccctccgca gcacaatgac cacaccacca
    13081 cagtccctca ccgccgccga agcatccgca cagtctttgg cctccggtgc agcaggaccc
    13141 gcgttgttgc acatcgaact ggccatgacc ggcaccggag gctgggccac agcccacgag
    13201 cacatccgcc aggtcaccgc aggccccgtc gacgccgccg cccacaccgg actgttctac
    13261 ggcgccccga cagtcgcctt cctcctgcac accgccggcg cggacgggaa accacgctac
    13321 cggcaagcag ccgcgacact cgaccggcac atcctccacc tgacccggca gcgggtagcc
    13381 gacgccaacg agcggataga ccacggcgaa aacactcggt tcagcgagta cgacctgctc
    13441 tacggcctaa ccggaatcgg ggcgctcctg ctgcgacacc tacccggcag cgacaccctc
    13501 gccgacctgc tgcactacct cgtccggctg accggaccgc accccgccga cgagcgtctc
    13561 ccgggctggt gggtggccca cgacccggac ccgctgttgc cgacccccgg cgggcacgcc
    13621 aacctcggca tggcccacgg cgcggccggc ctgctcgccc tgctggccct cgccacccgc
    13681 agcggtgtcc tggtcgacgg ccaacgcgag gcgatcgacc ggctccttgc ctggttcgac
    13741 acctggcgcc aagacggacc cgaaggaccc tggtggccac aatggctcac ccgggacgag
    13801 ttgcgcaccg gccgcgcagc ccaacccggc cccggccgcc ccagctggtg ctacggcacc
    13861 cccggcatcg cccgcgcact tcaactcgcc gcgatcgcca ccggcgacca gctacgccag
    13921 cgagcagccg aggacgccct cgccggctct ataagcgcac cgcgtctcca actgatcacc
    13981 gagccagggt tatgccacgg cgcggccggt ctctaccaga ccatcagccg cgccgcccac
    14041 gacgccgcca acccgaccct ccgccgacag ctgcccgcac tggccgaccg gctggcgcag
    14101 cacagcagca gcgcccacgg cgacgggctt ctcaccggtt cagccggtct caccctggct
    14161 ctggagaccg cacgaaatag acaaccgcca cgatcaggat gggacgcatg cctactgatc
    14221 agctgatacc cgccctgccc gacgacctcg cccgcggcgt gctcgcagta ctcgccggtt
    14281 ctgatccgtc caccaccgcc gcagaccttg gcatcacctc ggacgacctg accgacgccg
    14341 tacagctgta tcaagccgcc ggactggcgg cactggagca acgagccgag cacgaatggt
    14401 acgacctgcg gctacggttc cccgactggc ataccgctga agcagcggcg gccaaccgac
    14461 tcgcccccgc cctggaccaa ctcctgcagg agggggagac agccggctgg tggttcctac
    14521 gtaagcaccc cttctggcgg ctgcgcctcc accacgccga caccacggcc gtggcgcgcc
    14581 tactcgaaca gctgaccaga caaggcatcc tcaccggctg gcaccagacc atctatgaac
    14641 cagaaacggc cgccttcggt ggcccagcgg ctatcgacgc cgttcacgca ttgtcttgcg
    14701 ccgacagccg cggcctgctc aactacgtcc gacaaccatc gcccgcctta gggcgccgag
    14761 aaatgtcgat gctgctgttc accgcgttcc agcacgcggc aggactcgac tggttcgaac
    14821 aaggcgacgt gttcgaccga gtcgcgcggc tgcgccccac gcccaccggc tcggatgacc
    14881 agcgtgtcga aacgctctcc gccgacctct ccagcatcct gaccgcgaac gccaacgccc
    14941 acaccccgct gttcgcgccc ggcggcccgg cagctttcgc gagccgctgg cggaccgcgt
    15001 tcatccagac tggccacatg ctcggcgagg cggcggcacg aggtcgactc gaccgcggac
    15061 tccgcgcggt tatcgcacaa atagccatct tccactggaa tcgactcggc ctacccgccc
    15121 gaacgcaagg gatcctcgcc cacagcgcag caaccgcgct attgggcacc cggcttggct
    15181 gattctccgc ccagcagcgc ccctcccggc cgcctccaca cgacaatcca aacaacagcc
    15241 actggtctca cacgccgagg ctcgccagtc gcaaagtcga aaggaaaaga cgattaccac
    15301 cgtaagacaa ccaccaacca gcccgaccgg cgacgccgag ctgcgccggg ccctcgtcga
    15361 acgaatcagc gcccgtcgtc agctatcaga cgccgttgct gctgcgatgt acaaggtccc
    15421 gcggcacgtc tttgtgccca ccgcctctct tgaggaggcg tacgcaaacg acaccgtggt
    15481 cactcggcgc gacgacaccg gcatcgctac aagctcggcc tcggccccct ggctagtggg
    15541 acaaatgctt gaccaactcc agctccagcc aggtatgcga gttttggaga tcggggccgg
    15601 aaccggctac aacgcggcgt tgatcgccga gctggtcggc ccgaccggtc acgtgaccgc
    15661 cgtggagatc accccggacg tggcggccga cgcccgcaaa gcgctggcga ccatcggcgc
    15721 gaccaacgtc gagatcgtct gtggcgacgg cgagtacggc cacccgcagg ccgcggcgca
    15781 tgaccgaatc atctccaccg ccggagtatg ggagatccca gatgcgtggg cggagcagct
    15841 gtccccggaa ggggttctgg tcgctccgct gcggatgcgg ggtctgaccc gatcagtggc
    15901 catgacacgc gaggccggcg tgtggcgcag ccacagcact gtcacctgcg gatttatgcc
    15961 gatccgcggc aaaggcgaaa tgcccgagcg caacatccgc ccggcggagg atctgttcgt
    16021 ccgcttcgat gacgggcagg acgcggatgc gctggctctc gcgcaggcgg ccgccagccc
    16081 tggccgggtg gactggtcag gagtgctcat cgacaggtcg ctggaactgc tggatttcta
    16141 cctggccgag ttggatgggt tctgccgcgt gctggcttcg ccctcgatca ccgaacgggg
    16201 cctggccgaa cccgtcaacg actggggaag catgggcgcg gccacagacg aggcgctcgg
    16261 ctacctgacc aaacgcacct gccttgacaa cccctacctg tatgagcttg gcgtgtgcgc
    16321 ctacgggccg cgcgcagcgg cgatgctcgc cgacctgacc gaacgggttc accgctggga
    16381 ccgcgaccgc gagtcgatca ccggggtccg catcgagatc cacccacccg ggcagggcga
    16441 gatggccgac gcgctaatga tcgcggataa gcgacgctcg cgggtggtcg tccggccggt
    16501 ccggcaggaa tccaagtagc caagccctcc caccttgaaa gaccgcgacg ccggccgacc
    16561 ggaacgtctt aaagaaactg cggcacgacg taggcgacag tgccaaaccg gcgcaggccc
    16621 gcctcctcga cctagtaccg cgaccccgac aagcaacatg aaagttcgtc cacccgattc
    16681 acggtgcggc gctccaccga ccacggcgac gcggcggtga tggagtctgg gccgagagga
    16741 tccccggcct gaccaaactg cggtccccgg ccgctggcga ccgggccagg gtagtcggtg
    16801 tacgtcggcg gccgaccggt actcccgccg accgctggcc ggcggcggcc tcggggcccg
    16861 cgcctgtgtt cgctaactcg cgatagtcgg ctccgacgaa acgctcatgt cgacggtccg
    16921 tcatccgtgg ctgacgctaa tcggagaggc gatcgagatc ccgacgcatt tgctcccggc
    16981 acacctccga cgcctcgaac gtgccatcgg acagcgttcc gtcctccaaa gcaccgataa
    17041 actcgtcgga ccagctttcg cagtcgactc cgctgcggtc ccacagcact cctaccgcga
    17101 ccactacggc gacgagcagg attgccgccg ctatggtgca gtgcaggagc caacgggtgc
    17161 ggcgctgggg agcttgcagg tcgtgaccgg agcccggaag actcatgcaa ggcaccctcc
    17221 ccggccccgc tcggttttca cacgatccgg atcggcgtct cctcggccgc gaaccgagcc
    17281 acgaacccag ccagcgatga tcaacgaggg tcgagcagtc gcagggaact cctgaacgag
    17341 gcgataaggc tctccaagag tgccctacct ttcgccgggc tggcggcgga cggccggccc
    17401 accaccccgg aagcggtgta cgcctgcatt cccagcgtca gcaggtgggg ccggtgcggg
    17461 gcgtcgtagt ccgcgtcggc gtagctgccc cgcaccaggg tgggatgcag gtgcagcagc
    17521 agcgacgttt cgagctcacc ggcgtgcatg tcgtcgtggc tggtggtttc cagacctgcg
    17581 tcaacgcggg cacggttcca gtcatcccgg cctgggtaca gcgccatgac cggcccggcc
    17641 accgtcgcct cctggacgac gttcgagagc acgtagttgc cgccgtgccc attcacgatc
    17701 actagccggt caatcccgct cgcatgcagc gactcggcca catccttgat caccgtagcc
    17761 agcgtcgtgg cacggatgct tacggtaccc ggccacgccc agtgctcatg cgagcaggag
    17821 atcgtcagcg gaggcaacag cagcagtcgg taccgctcgg ccagcaccgc cgcgattgac
    17881 gaggcgatga tcgtgtccgt ggcaagcggc aggtggtcgc cgtgctgttc gtggctgccg
    17941 accggcagca gtgcgacact ggccccgagg gcgcccacct ccggcgatgt cgcggtcgta
    18001 atcacatcca ctcctacacc ctgccgtgtt ccccggaccc ggccaccacc cgggtggctg
    18061 gatggccgcc gacgggcacc gttgcggtac ggtccgcggc cacctcagtc accagcgaca
    18121 gggtgcgttg cgacccggtt tggagtccca gttctcgggc ggcggcggcg tgatctcggg
    18181 cggcgtccac gtcaccggcc aggtgcagcg cgacggcgaa gtgcgcacgg aagaacccct
    18241 cgtccaggcg ctggtggtgc ggccagtcgg ccagcaccgt ctcgaagtca tggatcgccg
    18301 ccgccggttc gcccagcagc agccgacagc atgcctcata cgcgcgtacg tagacgctgg
    18361 tgcagtggct caccagcgac gctgtctgcg ggtcctccgc tgccgactgg tcaacgagac
    18421 ggaatgcggt gccgatgctg cgccgggtgc cggtggcgtc gccgtggtgg gcatgtgcct
    18481 gtgccaggcg tacggccgcc agcgctcgca ctcgcggggg aagaccaccg gcccccagca
    18541 ctggttggac cagcgcctcc gctgccccga cctgcccttt ctcgacggca cgctgagcac
    18601 gtcgcatgcc cacgtaggca gtcagggtga cgtcaccggc ttcacgtgcc atcgacccgg
    18661 cggcttcgag ccaacgcccg gcctgttggt cgtggccctc gttgtcgcag atccaactcc
    18721 cgaactcgcg ccagcgtgca gcgaccacgg tgaggtcggt ccgggccggt ctggcggcgg
    18781 tctcgcgttg gctgtctatg agctgcagtt cggtgctgac gaggttgagt agtccgtgtc
    18841 ctcccagcgc gttatcggcc gcggtcagca ccctgagcat gtcgcgccag tgcgcggcga
    18901 gatccacggc cggtgttggc gtcaccgtgt cctgcggcag ctggacggcg gctggccgta
    18961 ccatcgccgt caactctccg ccggcgccga gcgcgtcgtc gagcctcgtg gcggtctccg
    19021 cgtccgcggc gaccatcccg gtttcgatct tgtggagctt ggacttactc gccaacgtaa
    19081 gccggccgag ctctcggaaa gacagggcgt gctgctcccg cagggtacgc atccgctgtc
    19141 cgaaacgggg gtcaggcggc gtgcgacgcg gcatggtggg aagctcccag gtggagggct
    19201 gggtggccgg tcgtatccgc cggtccgatc cacagcatat cgatatggtc ggctgccggg
    19261 cgacccagcc aacgggtgac ccgactaacg tcgcaatgcc gcacagtgtc cacgcccaac
    19321 gccgacggca agttgggcgc ttgttagggg gcggtgctcg cggcgttcct gagagtcgcc
    19381 gcggtgggga ctgcggcatg agagcggtcc gatcttggag gttaaagggg cctggcccgt
    19441 tgagggagtg tcagggcctc gaccggcggc tgcgtggggc gcccgcagag cgactacgag
    19501 tacaggacgg tccggattgc cgctggccag tacgcaggcc gagggcacct cgcccgtctc
    19561 cgtgaccgtg agctggaagc catcgaggct gacgggtggg agatcgtgac gatcgccccg
    19621 cgtcggctcg gcacgggcaa ggacgaggtc atctgtcgcc ggtcgagagg ctatcgccca
    19681 ccccagccga cccgcgcacc gtcatggtgg gagcaggtcc tggaggacct gtcgactccg
    19741 gtgtggctgc ggcgcctacg ccgccggcta cgcgactaaa cccctacctc tgggcacctt
    19801 ccggacagcg gccgtgtgga tccggaacgg ggcgtcggcg ggtgtcacgg tcctccccgg
    19861 ctggccacac gagcagcgtc tacccgactg cccaccctcg atctgcgcgg gcggtgcttg
    19921 ccgcgagcac cagggatcgt cgaggcacgt cagcgggtgg tcacggaact cgctcgttcg
    19981 gtggagtgta cgttcagccg ataaacggcc ggccgcgagg gatattgtgg tatacgacct
    20041 ggctcgggtt gccgagttac tccaccaacg caacacgatc gatgaacaga tcacacagat
    20101 catcaaacgc ccggtggcaa gcgggcacct cggcgagtgg attgccgcct gggtcttcga
    20161 catcgagctg gagacctcgg ccagcaccgc cgccgtcgac ggccggttcc tgactggcaa
    20221 gctgcaaggc cggaccgtca acatcaagtg gtatctcaag cgcgagggcc tgctcgacat
    20281 gaccactgct gatgtgccgg attactacct ggtcatgacc ggaccagccg gccctgccgc
    20341 atcctctcgg ggaggcagtc ggctgtggcg catcgacaac gtttacctgt tcgacgcgcg
    20401 gcagttgctc tccgaccagc ttgcccgcgg cgttaaggtg ggggtcgcgt caagcgtccc
    20461 acagagctgg tggaaggccg ccgagattta cccgaccgcc aacgacgccg tcctggccgt
    20521 atcccgggag caagcagcaa tgctggcgtt attccgtcca cggtagcctt cggcgatcct
    20581 gccagggaca gccataggac agcggctcgg gcgggcgctc atctgccgcg acctgcacgg
    20641 cgaaacgcaa tgatctaact gggttgtgcg agcgtgggtc tggaatgagc tgatctcact
    20701 cacgctgtgt tgcgtcggcg gaagtcgtcg gcgccctggc ggtggcgcat ccagacggcg
    20761 acatccagga tacggattgg gctgaccggg tccggcagtc cggcatctcc cttcagctgg
    20821 acgagctggc ggtgaagcgc cgagtcgtct tgctggagca cacggcgtag gcaggtccag
    20881 tagcagccca cccggtaacc ggctccgccg gcgacgacgc tgtcgtatat cggcaggagt
    20941 cgcggccgct tgcgggcgag gagcttgctg gccttgaccc acctaacgtt cggttggttg
    21001 atcagcagtt gccacgcccg gtctgcgggc ccgccgtcgg cgactgggtc tggttggagg
    21061 ttgcctgagc tggccaggtc aacctgccgc gggacctcag cgagcagggc ggagagctgc
    21121 acaccaaggt cgccgacgag gagccacagg gcgaccttcg ctgggtactg gacgcccagc
    21181 atctccacgg ccatcaggtc ctcggcagtg atccgattcg cggtgtccgg ccggtcgcca
    21241 ccaccaccca gctggtcgaa ccaacccccc gtgaacagag gaggggtcgc cgaacgcggc
    21301 tcgccgacgt ggtagtaggt gagtagatcc ttcacagagt cctgcaggag agcgctgagg
    21361 cggtctccat tgagctcaca cacaagtcct cctgcctgcc gtaccagtgc acttggattc
    21421 ccaccgaggc cagtctgact gatcgccggg ggtccgcggg gccgcgctca ccggaggtga
    21481 tcgcggcacc tacctgcgca cagaggaaca ggcggattgc ttcgcggggc aggtgtcttg
    21541 cgtgaccgcg gcgggcctgg atgggccgcc gccctcgcct agcatgcact ggcgctccgt
    21601 agtgaccacc tgtggcgaca atgtcggact aggccgacgc ctgcaaacgg cttctcgggg
    21661 cagtggacgg gctggcgcac accgaacgga cccgcccggg ggtcctgtgc cagctccagc
    21721 ttaccgtcta cacgccacaa cggtgaccct gaccaagccg cagcctgtgc agccgacgcc
    21781 aaagacgccc gcgaaccgct cgcttcagcc gctcgccagg gagcttgggc tcgaccttcg
    21841 cggcgacgcg gccggcgaaa cgcgcatgac cctcacatcg ttcgatcaaa catgttgtgc
    21901 cctgtcggac gcggacggta gtgtgcggct tctcgtagag ccaggacaac atggaggtgg
    21961 cgcccgtgat cgtggggctg ggcggtgtgg ccgtggcggt cgaatccgat tgtacgctgg
    22021 tgcatcagct gattgccgag ttctatccgg tggagtcggg ccccagtgag ccgatgtgga
    22081 cgattgtcgc ctatgcgcag gcaccgcctc gcggcgttgc cgtgaaccgc ttcggggtgg
    22141 gctaccagcc ggacctagcc ggccgctcgc tcatcctgtg ggccacacgg gagacggatc
    22201 tggcgatcac gacccgcaag tgtgtgcggg agatcttcct cgatgcctgt gagcgggcag
    22261 gctacgggat gctgcacgcg tcggctgtct accacgacga ccaggccatc gtgttcgccg
    22321 cggacaagcg tggtgggaag acgacgcttg cgttgcgcgc ggtactcgat cacgggtggc
    22381 ggtggctgtc caacgaccac ctgatcgtct ggcgtggcga ggctgggctg gtggccacct
    22441 ccttgcctac cccgatccca ctgaaggtgg gtacgtacgt cgacctgatc gaccgcctgc
    22501 cgccgccctg ggactccaac gggatcaacg cggagatgtg gcgagcagcc acgcccgtcg
    22561 cccggtacgc ctccgacgcg gcggtctact acaccttcgg ccggctcgga caggcgaacc
    22621 cggtgctggt cgagctggcc ggtcggcggc tgacggtggt gttcccctcc tacgccgggc
    22681 cggggcagcg ggaaggcgtg gtggagatgg tgccggctca ggccgctgcg tcggagctgg
    22741 ctgggcatgg gcgtaccgac tggatagagg atcagcggct ccaccagcgg caccttccct
    22801 tcccacaccg cgatgtcgcc gccttcggcc gggatagcgt ggtcctggcc gcgcaggtcg
    22861 ccgccgcagg ggccgaggtt gtccggttca cgcatcgggg cgacccttcc ccgttgctcg
    22921 tcaacgttgc cgaggcggtg ccccgatgag gcggcgtccg ctggtcagcg tggtggtgtg
    22981 cacctacgcg cgtcccgagc cgctacgcgc ggcgctggcg agcatctgcg tacagggcgt
    23041 ggacggggtg gaggcggtgg tcgtcaacga tggcgggccg gacgttgccg gtgtggtggc
    23101 tgagttcggc gaccggctcc cggtgcggct aatcaccctg cctacgaaca agggcctgac
    23161 ggcggctcgc cgcagcggca taggtgctgc tcgtggccgg ttcgtcgcgt tccttgacga
    23221 cgatgacctg tggctccccg atcatctctc cgtggccttg gacggtctcg acagcgggtt
    23281 ggacctggtg tacacgacct gcctagtcgc cgaccgcgtg catcacctcg gctccgaaga
    23341 acccgtttcg gcacggtacc ggttcgacta cccgttcgac gccgcactgt tcgacgtgac
    23401 gaacatgatc ccggtgacct cagtcgtcgc gcgcaggttc gaccccgcga tgcttcatcg
    23461 gcatgacggg gtgcaggacg actgggcgat gtggctcgac ctggtacgcg gtgccgggtg
    23521 gcgtctcctt cacctgccgg cggccacgac ggtgtatcac cgcatcccgc aggcggcgtc
    23581 gatgaccggg caagcagcga gcaccctggc cgggttgcgg cggttcgccg ccgggcatcg
    23641 gcggatacat cagcggtggc cggtgccaaa cggtagccgg gccggacagg cacgccggtt
    23701 gccgttctgg atgtatcggc tggtggagca gcgtcacagc gccgggcatg gggtgtccca
    23761 ctactactat gagcggtgcc tgccgctggt cgccgcagcc gtgaccgggc ggatgaccat
    23821 taacgcggcg gtcgacgcga tggacgtggc cgtcgcacct gatgcggtcg aggagaggga
    23881 gcaggcggca tggcgagtgc tggcgtgatc gacccaccgc tgcgcgcccg gatacgggcc
    23941 gccctgcctg acgcccaggt ggacacggtg ctgcacgaca acggcaaagc actagtgttg
    24001 tccggcacgg tcgccggcca gcgtgcggtg gtgaaggtcc ttgtggaccc ggacccgttc
    24061 tgggcgggca agttccccgc tgagataacg atctaccggg cgttcgaggt agcgccaccg
    24121 ccggcaccgg tgccgaagct gcaacaccaa ccgcgccacg tcggcccact ccgcacggca
    24181 gtacttcgcc ccttcgccgg gcccacagcc cgaggatctc ccgcccaccg tcggcggtaa
    24241 ccgccagcgc cacgtagacg ggccggttgg cgacctgccc gtcgcggatc ttcacgtgga
    24301 tacagtcgat gaaaatcacc gggtagatcg gatccagcgg ccggttctgc cactcgccca
    24361 tgatccccag cacccggtcg gtgatcgtcg agatgtgatc acgcgacacc gtcgcgccgt
    24421 acacctcggc cagatgcgcg cacacctcac cagtggtcaa ccctttggcg gtcaggctga
    24481 tcaccagatc gtcgatgccg cccatccgcc gctgccgctt ggccacgatc tgcggggtga
    24541 aactggcgtc ccggtcgcgt ggcacgccca ccctgaccgg gccgacctcg gtcagcaacg
    24601 tcttggaccg gcagccgtta cggctgttgg cgccatcacg accggccggc tcgtgcttgc
    24661 cgtagccgag atgctcgtcc atctccgctg ccagcgtggc ctccaggaac cgtttggtca
    24721 gctgctgcag cagcccgtcg cggcccagca gcgacacgcc ctgcgcccgg ccagccgggc
    24781 caccagctgc gggtccaacg ccgccgcagc cgcctcacct ttaggtcctt ccggctggtg
    24841 cagcaccgcc ggcgcccagg cgaggccgtg gccctcgccc gccgtcatcg cggtcctggt
    24901 cttggtcgtc accgggtgtc tccttgtcct atatttcgga cttacaccct cctaatgaca
    24961 gtccccgaac cggcaaagcc cggcccacgg tagagctcga cgcccggcgc gagccgtccg
    25021 cgtacagcaa ctggcggtgg atcgccgcgc accactcgcg tgcggcgctg gtgctcggca
    25081 tcgatccgta tgcaaaacgc cgaccatgcg gaggtacgcc tgcgactcga ccaatgcgaa
    25141 gaggccgatt ggtcagttgg tacatctgcc accgaccatg cc
//
